                         SEQUENCE LISTING

<110>  VENDITTI, Charles P.
       CHANDLER, Randy J.
       CHAU, B. Nelson
       CHIANG, Kyle P.
       LIAO, Jing
 
<120>  NON-DISRUPTIVE GENE THERAPY FOR THE TREATMENT OF MMA

<130>  2012538-0062

<150>  62/717,771
<151>  2018-08-10

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Lys Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  2
<211>  2215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  2
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg ctgcaggcgg tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacgac aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca gcagcgagta tcaaagacat ctgcggataa caacaacagt     1500

gaatactcgt ggactggagc taccaagtac cacctcaatg gcagagactc tctggtgaat     1560

ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa agtttttttc ctcagagcgg     1620

ggttctcatc tttgggaagc aaggctcaga gaaaacaaat gtggacattg aaaaggtcat     1680

gattacagac gaagaggaaa tcaggacaac caatcccgtg gctacggagc agtatggttc     1740

tgtatctacc aacctccaga gaggcaacag acaagcagct accgcagatg tcaacacaca     1800

aggcgttctt ccaggcatgg tctggcagga cagagatgtg taccttcagg ggcccatctg     1860

ggcaaagatt ccacacacgg acggacattt tcacccctct cccctcatgg gtggattcgg     1920

acttaaacac cctccgcctc agatcctgat caagaacacg cctgtacctg cggatcctcc     1980

gaccaccttc aaccagtcaa agctgaactc tttcatcacc cagtattcta ctggccaagt     2040

cagcgtggag atcgagtggg agctgcagaa ggaaaacagc aagcgctgga accccgagat     2100

ccagtacacc tccaactact acaaatctac aagtgtggac tttgctgtta atacagaagg     2160

cgtgtactct gaaccccgcc ccattggcac ccgttacctc acccgtaatc tgtaa          2215


<210>  3
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  3

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Arg Gly Leu Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  4
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  4

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  5
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  5
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcga       60

gagtggtggg cgctgcaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccggcaa cggactcgac      180

aagggggaac ccgtcaacgc agcggacgcg gcagccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

aaagaggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgacta gaactgtcaa tgatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  6
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  6

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  7
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  7
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

aaagaggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcgacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc agggacccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  8
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  8

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asp Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  9
<211>  2253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  9
atgctgagag ccaaaaacca gctgttcctg ctgagccccc actatctgag acaggtcaaa       60

gaaagttccg ggagtagact gatccagcag agactgctgc accagcagca gccactgcat      120

cctgagtggg ccgctctggc caagaaacag ctgaagggca aaaacccaga agacctgatc      180

tggcacactc cagaggggat ttcaatcaag cccctgtaca gcaaaaggga cactatggat      240

ctgccagagg aactgccagg agtgaagcct ttcacccgcg gaccttaccc aactatgtat      300

acctttcgac cctggacaat tcggcagtac gccggcttca gtactgtgga ggaatcaaac      360

aagttttata aggacaacat caaggctgga cagcagggcc tgagtgtggc attcgatctg      420

gccacacatc gcggctatga ctcagataat cccagagtca ggggggacgt gggaatggca      480

ggagtcgcta tcgacacagt ggaagatact aagattctgt tcgatggaat ccctctggag      540

aaaatgtctg tgagtatgac aatgaacggc gctgtcattc ccgtgctggc aaacttcatc      600

gtcactggcg aggaacaggg ggtgcctaag gaaaaactga ccggcacaat tcagaacgac      660

atcctgaagg agttcatggt gcggaatact tacatttttc cccctgaacc atccatgaaa      720

atcattgccg atatcttcga gtacaccgct aagcacatgc ccaagttcaa ctcaattagc      780

atctccgggt atcatatgca ggaagcagga gccgacgcta ttctggagct ggcttacacc      840

ctggcagatg gcctggaata ttctcgaacc ggactgcagg caggcctgac aatcgacgag      900

ttcgctccta gactgagttt cttttgggga attggcatga acttttacat ggagatcgcc      960

aagatgaggg ctggccggag actgtgggca cacctgatcg agaagatgtt ccagcctaag     1020

aactctaaga gtctgctgct gcgggcccat tgccagacat ccggctggtc tctgactgaa     1080

caggacccat ataacaatat tgtcagaacc gcaatcgagg caatggcagc cgtgttcgga     1140

ggaacccaga gcctgcacac aaactccttt gatgaggccc tggggctgcc taccgtgaag     1200

tctgctagga ttgcacgcaa tacacagatc attatccagg aggaatccgg aatcccaaag     1260

gtggccgatc cctggggagg ctcttacatg atggagtgcc tgacaaacga cgtgtatgat     1320

gctgcactga agctgattaa tgaaatcgag gaaatggggg gaatggcaaa ggccgtggct     1380

gagggcattc caaaactgag gatcgaggaa tgtgcagcta ggcgccaggc acgaattgac     1440

tcaggaagcg aagtgatcgt cggggtgaat aagtaccagc tggagaaaga agacgcagtc     1500

gaagtgctgg ccatcgataa cacaagcgtg cgcaatcgac agattgagaa gctgaagaaa     1560

atcaaaagct cccgcgatca ggcactggcc gaacgatgcc tggcagccct gactgagtgt     1620

gctgcaagcg gggacggaaa cattctggct ctggcagtcg atgcctcccg ggctagatgc     1680

actgtggggg aaatcaccga cgccctgaag aaagtcttcg gagagcacaa ggccaatgat     1740

cggatggtga gcggcgctta tagacaggag ttcggggaat ctaaagagat taccagtgcc     1800

atcaagaggg tgcacaagtt catggagaga gaagggcgac ggcccaggct gctggtggca     1860

aagatgggac aggacggaca tgatcgcgga gcaaaagtca ttgccaccgg gttcgctgac     1920

ctgggatttg acgtggatat cggccctctg ttccagacac cacgagaggt cgcacagcag     1980

gcagtcgacg ctgatgtgca cgcagtcgga gtgtccactc tggcagctgg ccataagacc     2040

ctggtgcctg aactgatcaa agagctgaac tctctgggca gaccagacat cctggtcatg     2100

tgcggcggcg tgatcccacc ccaggattac gaattcctgt ttgaggtcgg ggtgagcaac     2160

gtgttcggac caggaaccag gatccctaag gccgcagtgc aggtcctgga tgatattgaa     2220

aagtgtctgg aaaagaaaca gcagtcagtg taa                                  2253


<210>  10
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu 
            20                  25                  30          


Leu His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys 
        35                  40                  45              


Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro 
    50                  55                  60                  


Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp 
65                  70                  75                  80  


Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr 
                85                  90                  95      


Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly 
            100                 105                 110         


Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys 
        115                 120                 125             


Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg 
    130                 135                 140                 


Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala 
145                 150                 155                 160 


Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly 
                165                 170                 175     


Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val 
            180                 185                 190         


Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val 
        195                 200                 205             


Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu 
    210                 215                 220                 


Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys 
225                 230                 235                 240 


Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe 
                245                 250                 255     


Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp 
            260                 265                 270         


Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser 
        275                 280                 285             


Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg 
    290                 295                 300                 


Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala 
305                 310                 315                 320 


Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met 
                325                 330                 335     


Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln 
            340                 345                 350         


Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val 
        355                 360                 365             


Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser 
    370                 375                 380                 


Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys 
385                 390                 395                 400 


Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser 
                405                 410                 415     


Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu 
            420                 425                 430         


Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu 
        435                 440                 445             


Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro 
    450                 455                 460                 


Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp 
465                 470                 475                 480 


Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys 
                485                 490                 495     


Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn 
            500                 505                 510         


Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala 
        515                 520                 525             


Leu Ala Glu His Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly 
    530                 535                 540                 


Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys 
545                 550                 555                 560 


Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His 
                565                 570                 575     


Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly 
            580                 585                 590         


Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg Val His Lys Phe Met 
        595                 600                 605             


Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln 
    610                 615                 620                 


Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp 
625                 630                 635                 640 


Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu 
                645                 650                 655     


Val Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Val Ser 
            660                 665                 670         


Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu 
        675                 680                 685             


Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val 
    690                 695                 700                 


Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn 
705                 710                 715                 720 


Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu 
                725                 730                 735     


Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
            740                 745                 750 


<210>  11
<211>  2253
<212>  DNA
<213>  Homo sapiens

<400>  11
atgttaagag ctaagaatca gcttttttta ctttcacctc attacctgag gcaggtaaaa       60

gaatcatcag gctccaggct catacagcaa cgacttctac accagcaaca gccccttcac      120

ccagaatggg ctgccctggc taaaaagcag ctgaaaggca aaaacccaga agacctaata      180

tggcacaccc cggaagggat ctctataaaa cccttgtatt ccaagagaga tactatggac      240

ttacctgaag aacttccagg agtgaagcca ttcacacgtg gaccatatcc taccatgtat      300

acctttaggc cctggaccat ccgccagtat gctggtttta gtactgtgga agaaagcaat      360

aagttctata aggacaacat taaggctggt cagcagggat tatcagttgc ctttgatctg      420

gcgacacatc gtggctatga ttcagacaac cctcgagttc gtggtgatgt tggaatggct      480

ggagttgcta ttgacactgt ggaagatacc aaaattcttt ttgatggaat tcctttagaa      540

aaaatgtcag tttccatgac tatgaatgga gcagttattc cagttcttgc aaattttata      600

gtaactggag aagaacaagg tgtacctaaa gagaagctta ctggtaccat ccaaaatgat      660

atactaaagg aatttatggt tcgaaataca tacatttttc ctccagaacc atccatgaaa      720

attattgctg acatatttga atatacagca aagcacatgc caaaatttaa ttcaatttca      780

attagtggat accatatgca ggaagcaggg gctgatgcca ttctggagct ggcctatact      840

ttagcagatg gattggagta ctctagaact ggactccagg ctggcctgac aattgatgaa      900

tttgcaccaa ggttgtcttt cttctgggga attggaatga atttctatat ggaaatagca      960

aagatgagag ctggtagaag actctgggct cacttaatag agaaaatgtt tcagcctaaa     1020

aactcaaaat ctcttcttct aagagcacac tgtcagacat ctggatggtc acttactgag     1080

caggatccct acaataatat tgtccgtact gcaatagaag caatggcagc agtatttgga     1140

gggactcagt ctttgcacac aaattctttt gatgaagctt tgggtttgcc aactgtgaaa     1200

agtgctcgaa ttgccaggaa cacacaaatc atcattcaag aagaatctgg gattcccaaa     1260

gtggctgatc cttggggagg ttcttacatg atggaatgtc tcacaaatga tgtttatgat     1320

gctgctttaa agctcattaa tgaaattgaa gaaatgggtg gaatggccaa agctgtagct     1380

gagggaatac ctaaacttcg aattgaagaa tgtgctgccc gaagacaagc tagaatagat     1440

tctggttctg aagtaattgt tggagtaaat aagtaccagt tggaaaaaga agacgctgta     1500

gaagttctgg caattgataa tacttcagtg cgaaacaggc agattgaaaa acttaagaag     1560

atcaaatcca gcagggatca agctttggct gaacgttgtc ttgctgcact aaccgaatgt     1620

gctgctagcg gagatggaaa tatcctggct cttgcagtgg atgcatctcg ggcaagatgt     1680

acagtgggag aaatcacaga tgccctgaaa aaggtatttg gtgaacataa agcgaatgat     1740

cgaatggtga gtggagcata tcgccaggaa tttggagaaa gtaaagagat aacatctgct     1800

atcaagaggg ttcataaatt catggaacgt gaaggtcgca gacctcgtct tcttgtagca     1860

aaaatgggac aagatggcca tgacagagga gcaaaagtta ttgctacagg atttgctgat     1920

cttggttttg atgtggacat aggccctctt ttccagactc ctcgtgaagt ggcccagcag     1980

gctgtggatg cggatgtgca tgctgtgggc ataagcaccc tcgctgctgg tcataaaacc     2040

ctagttcctg aactcatcaa agaacttaac tcccttggac ggccagatat tcttgtcatg     2100

tgtggagggg tgataccacc tcaggattat gaatttctgt ttgaagttgg tgtttccaat     2160

gtatttggtc ctgggactcg aattccaaag gctgccgttc aggtgcttga tgatattgag     2220

aagtgtttgg aaaagaagca gcaatctgta taa                                  2253


<210>  12
<211>  2253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  12
atgctgcgag cgaaaaatca gctttttctg ttgagcccac actacctgag gcaggttaaa       60

gaatccagcg ggagccggct gattcagcag cgactgctcc accagcagca gcctttgcat      120

cccgaatggg ctgctttggc gaagaagcag ctcaagggga agaaccctga agatcttatt      180

tggcacaccc cagagggcat cagcatcaag cctttgtatt ccaaaaggga caccatggat      240

ctgcctgaag aattgcccgg ggtcaaacca ttcacacggg ggccatatcc aaccatgtac      300

accttccggc catggactat cagacagtat gcaggcttta gcactgtcga ggaatccaat      360

aagttctata aagacaatat caaagctggc cagcaaggtc tgtccgtggc attcgatctg      420

gctacacata gaggttatga ttctgacaat ccaagagtac ggggagacgt cggaatggcg      480

ggagttgcca ttgacacagt ggaggacacc aagatacttt tcgatgggat tccattggag      540

aaaatgtctg tgtcaatgac gatgaacggc gctgtgattc ccgttttggc gaacttcatc      600

gtcaccgggg aagagcaggg cgtcccgaag gaaaagctca ccgggacaat ccaaaacgac      660

attcttaaag aattcatggt gagaaatacc tacatctttc ctcctgagcc ttccatgaag      720

atcatcgcgg acatctttga atacacggct aaacacatgc ctaaatttaa ctcaatcagc      780

ataagcgggt accacatgca ggaggccggc gctgacgcta tacttgagct cgcatatacc      840

ctggcagatg gactggaata ctcaaggacc gggctccagg ctggactgac aatcgacgag      900

tttgcccccc gactcagttt tttctggggt atcgggatga atttctacat ggagatagcg      960

aagatgaggg cgggcagacg gctttgggcg catctgatcg agaaaatgtt ccagcccaag     1020

aattcaaaga gtctgctgct gagagcccac tgccagacct caggctggag cctgactgaa     1080

caggacccat acaacaacat tgttagaacc gccatcgagg cgatggcagc ggttttcggt     1140

gggacacagt cattgcacac taactcattt gacgaagccc tcggtctgcc taccgtgaag     1200

tcagctcgga tcgctaggaa cacacagatc atcatccagg aggagagtgg catcccaaaa     1260

gtcgccgatc cttggggagg aagttacatg atggaatgcc tcacgaatga cgtatacgat     1320

gccgcactca agctgattaa cgagatcgag gaaatgggag gcatggcaaa agctgtcgcc     1380

gagggcattc caaagctgcg catagaggag tgtgccgccc gaagacaggc ccgcattgac     1440

tccggctctg aggtgatagt gggcgttaat aaatatcagc tagagaagga agacgccgtc     1500

gaagttctgg cgatagataa tacctctgtg cgaaatagac agattgagaa actgaagaag     1560

atcaagtcaa gccgagacca ggccttggcc gagaggtgtc tggcagccct cactgagtgc     1620

gcggcatctg gggacggcaa catattggca cttgccgtcg atgcctccag ggcccgatgt     1680

acggtcggcg aaattaccga tgccctcaag aaggtttttg gcgagcacaa ggctaacgac     1740

aggatggtta gtggagcata cagacaggag tttggcgaaa gcaaggaaat tacttccgcg     1800

attaaaagag tgcacaaatt catggaacgg gagggtaggc gaccgaggct cctcgttgcc     1860

aaaatgggtc aggacggcca cgaccggggc gccaaggtta tcgctaccgg tttcgctgac     1920

ctgggcttcg atgtggatat cggaccactg tttcaaaccc ccagagaagt tgcccaacaa     1980

gccgttgacg ctgacgtaca cgctgtaggc atctccactc tcgccgccgg gcataagact     2040

ctcgtcccag agctgataaa ggagcttaac agcctcggaa gacccgacat cctggttatg     2100

tgcggtggag tgattccgcc gcaggattac gaattcctct tcgaagtagg agtgtcaaac     2160

gtgttcggcc caggcactcg gatacccaag gctgccgttc aggtgcttga cgacattgaa     2220

aaatgtctgg agaagaagca acaatctgta taa                                  2253


<210>  13
<211>  2253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  13
atgttgaggg ctaaaaacca gctctttctg ttgagtccac actaccttag gcaagtgaag       60

gaatctagcg gtagcaggct gatccagcag cgcctgctgc accagcagca gcccctgcac      120

cctgagtggg ctgcattggc aaagaaacaa ctgaagggta aaaatcctga agatctgatt      180

tggcacacac cggaggggat ttccataaaa cctctctact ctaaacgcga tactatggat      240

ctgcccgagg aattgccagg agtgaaaccc tttacaaggg ggccctaccc cactatgtac      300

acgttcagac cctggactat acgccagtat gccggatttt ctaccgttga ggaatccaac      360

aagttttata aggacaacat caaagccggg cagcagggac tgtcagtggc atttgatctc      420

gccacccacc gcgggtacga ctccgacaac ccaagagtcc gcggtgacgt cggcatggca      480

ggggttgcca ttgacacagt agaggatact aaaattttgt ttgatgggat ccccctagag      540

aagatgtccg tgtctatgac gatgaacggc gcggtaatcc cagtgcttgc caacttcata      600

gtcacagggg aagagcaggg cgtaccaaag gagaagctca caggaacaat ccaaaatgac      660

attctgaagg aattcatggt gagaaatact tatatctttc ctcccgagcc ctctatgaag      720

attattgccg acatttttga atacaccgca aaacatatgc ccaagttcaa ttccatatct      780

attagtggat accacatgca agaagctggg gctgatgcaa tacttgagct tgcctacacc      840

ctggccgacg gactggagta ttctcgcact ggcctgcaag ccgggctgac aattgacgag      900

ttcgccccac gccttagctt cttctggggc atcggcatga atttctatat ggagatcgca      960

aagatgagag cagggcggcg cttgtgggcc catctgatcg aaaagatgtt tcagcctaag     1020

aatagtaaga gcctgctcct gcgggctcac tgtcagacgt caggctggag cctcacagag     1080

caggatcctt acaataacat cgtccggact gctattgagg cgatggctgc agtattcgga     1140

ggaacacaaa gcctgcacac taattctttc gatgaggctt tggggctccc taccgtgaag     1200

tcagccagaa ttgcaagaaa cacccaaata atcatccaag aagaatcagg gatcccaaaa     1260

gttgccgacc cctggggagg aagttatatg atggagtgcc tgaccaatga cgtctacgac     1320

gccgctttga agctgattaa cgagattgaa gagatgggcg gaatggccaa ggcggtcgct     1380

gagggcattc cgaaactgcg catagaggag tgtgctgctc gcaggcaggc cagaattgat     1440

tccggttccg aagtgatcgt gggggttaat aagtatcaac tggaaaaaga ggacgctgtc     1500

gaagtcctcg caatcgataa taccagcgtt agaaaccgac aaattgagaa gctgaaaaag     1560

atcaaaagtt caagggacca ggccttggct gagcggtgtc tcgccgcact gaccgaatgt     1620

gccgccagcg gcgatggtaa catcctcgcc ctcgctgtgg acgcttccag agcccggtgc     1680

accgtgggcg aaattacgga cgcgctgaaa aaagtctttg gcgaacacaa ggccaatgat     1740

agaatggtga gtggcgccta taggcaggag ttcggcgaga gtaaagaaat aacatccgcc     1800

atcaagaggg tccacaaatt tatggagcgg gaaggacgca gacctagact tctcgtggcc     1860

aaaatgggtc aggacggtca tgaccgggga gccaaagtca tcgcaacggg cttcgccgat     1920

ttggggtttg acgtggatat cggtcccttg tttcaaaccc ccagggaggt ggctcagcag     1980

gctgtggacg ctgacgtcca cgcagtgggc atttctacac tggcagccgg gcacaagacg     2040

ttggtgccag aactgatcaa agagttgaac agcctgggac gccctgacat cctggtaatg     2100

tgcggtgggg taatcccccc ccaagactac gagttccttt tcgaagtggg tgtttctaac     2160

gtgttcggac ctggaacaag aatccctaag gcggcagtgc aggtgcttga cgatatcgag     2220

aagtgcctgg agaaaaagca acaatccgtt taa                                  2253


<210>  14
<211>  2253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  14
atgcttcgcg ccaagaacca actgttcctg ctgtcccccc actacctccg acaagtcaag       60

gagagctcgg gaagccgcct gattcagcag cggctgctgc accagcagca gcccctgcat      120

ccggaatggg cagcgttggc aaagaagcag ctgaagggaa agaaccctga ggacctgatc      180

tggcacaccc cggagggaat ctcgatcaag ccactgtact ccaaaaggga caccatggac      240

ttgcctgaag aacttccggg cgtgaagcct tttacccggg ggccataccc aacaatgtac      300

actttccgcc cctggaccat cagacagtac gccggtttct ccaccgtcga agaatccaac      360

aagttctata aggacaacat caaggccggg cagcagggac tgagcgtcgc gtttgacctg      420

gcaacccatc gcggctacga ctccgacaac cctcgcgtgc ggggggacgt gggaatggcc      480

ggagtggcta tcgacaccgt ggaggacacc aagattctct tcgacggaat cccgctggaa      540

aagatgtcgg tgtccatgac catgaatggc gccgtgatcc cggtgctcgc gaacttcatc      600

gtgacgggag aggaacaggg agtgccgaaa gagaagctga ccgggactat tcagaatgac      660

atcctcaagg agttcatggt ccgcaacact tacattttcc ctcctgaacc ctcgatgaag      720

atcatcgctg acatcttcga gtacaccgcg aagcacatgc cgaagttcaa ctcgatctcc      780

atctcgggct accacatgca ggaggccggg gccgacgcca ttctcgaact ggcgtacact      840

ctggcggatg gtctggaata ctcacgcacc ggactgcagg ccggactgac aatcgacgag      900

ttcgccccga ggctgtcctt cttctggggc attgggatga acttctatat ggaaatcgcg      960

aagatgagag ctggaaggcg gctgtgggcg cacctgatcg agaagatgtt ccagcccaag     1020

aacagcaaaa gccttctcct ccgcgcccac tgccaaactt ccggctggtc actgaccgag     1080

caggatccgt acaacaacat tgtccggact gccattgagg ccatggccgc tgtgttcgga     1140

ggcactcagt ccctccacac taactccttc gacgaggccc tgggtctgcc gaccgtgaag     1200

tccgcccgga tagccagaaa tactcaaatc attatccagg aggaaagcgg aatccccaag     1260

gtcgccgacc cttggggagg atcttacatg atggagtgtt tgaccaatga cgtctacgac     1320

gccgccctga agctcattaa cgaaatcgaa gagatgggcg gaatggccaa ggccgtggct     1380

gagggcatcc cgaagctgag aatcgaggaa tgcgccgccc ggagacaggc ccgcattgat     1440

agcggcagcg aggtcattgt gggcgtgaac aagtaccagc ttgaaaagga ggacgccgtg     1500

gaagtgctgg caatcgataa cacctccgtg cgcaaccggc agatcgaaaa gctcaagaag     1560

attaagtcct cacgggacca ggcactggcg gagagatgcc tcgccgcgct gaccgaatgc     1620

gctgcctcgg gagatggcaa cattctggcc ctggcagtgg acgcctctcg ggctcggtgc     1680

actgtggggg agatcaccga cgccctcaag aaagtgttcg gtgaacataa ggccaacgac     1740

cggatggtgt ccggagcgta ccgccaggaa tttggcgaat caaaggaaat cacgtccgca     1800

atcaagaggg tgcacaaatt catggaacgg gagggcagac ggcccagact gctcgtggct     1860

aaaatgggac aagatggtca cgaccgcggc gccaaggtca tcgcgactgg cttcgccgat     1920

ctcggattcg acgtggacat cggacctctg tttcaaactc cccgggaagt ggcccagcag     1980

gccgtggacg cggacgtgca tgccgtcggg atctcaaccc tggcggccgg ccataagacc     2040

ctggtgccgg aactgatcaa ggagctgaac tcgctcggcc gccccgacat cctcgtgatg     2100

tgtggcggag tgattccgcc acaagactac gagttcctgt tcgaagtcgg ggtgtccaac     2160

gtgttcggtc ccggaaccag aatcccgaag gctgcggtcc aagtgctgga tgatattgag     2220

aagtgccttg agaaaaagca acagtcagtg tga                                  2253


<210>  15
<211>  4615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  15
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg       60

cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttccttacgt aactccatga aagtggattt tattatcctc      180

atcatgcaga tgagaatatt gagacttata gcggtatgcc tgagccccaa agtactcaga      240

gttgcctggc tccaagattt ataatcttaa atgatgggac taccatcctt actctctcca      300

tttttctata cgtgagtaat gttttttctg tttttttttt ttctttttcc attcaaactc      360

agtgcacttg ttgagcttgt gaaacacaag cccaaggcaa caaaagagca actgaaagct      420

gttatggatg atttcgcagc ttttgtagag aagtgctgca aggctgacga taaggagacc      480

tgctttgccg aggaggtact acagttctct tcattttaat atgtccagta ttcatttttg      540

catgtttggt taggctaggg cttagggatt tatatatcaa aggaggcttt gtacatgtgg      600

gacagggatc ttattttaca aacaattgtc ttacaaaatg aataaaacag cactttgttt      660

ttatctcctg ctctattgtg ccatactgtt aaatgtttat aatgcctgtt ctgtttccaa      720

atttgtgatg cttatgaata ttaataggaa tatttgtaag gcctgaaata ttttgatcat      780

gaaatcaaaa cattaattta tttaaacatt tacttgaaat gtggtggttt gtgatttagt      840

tgattttata ggctagtggg agaatttaca ttcaaatgtc taaatcactt aaaattgccc      900

tttatggcct gacagtaact tttttttatt catttgggga caactatgtc cgtgagcttc      960

cgtccagaga ttatagtagt aaattgtaat taaaggatat gatgcacgtg aaatcacttt     1020

gcaatcatca atagcttcat aaatgttaat tttgtatcct aatagtaatg ctaatatttt     1080

cctaacatct gtcatgtctt tgtgttcagg gtaaaaaact tgttgctgca agtcaagctg     1140

ccttaggctt aggcagcggc gccaccaact tcagcctgct gaaacaggcc ggcgacgtgg     1200

aagagaaccc tggccccctg agagccaaaa accagctgtt cctgctgagc ccccactatc     1260

tgagacaggt caaagaaagt tccgggagta gactgatcca gcagagactg ctgcaccagc     1320

agcagccact gcatcctgag tgggccgctc tggccaagaa acagctgaag ggcaaaaacc     1380

cagaagacct gatctggcac actccagagg ggatttcaat caagcccctg tacagcaaaa     1440

gggacactat ggatctgcca gaggaactgc caggagtgaa gcctttcacc cgcggacctt     1500

acccaactat gtataccttt cgaccctgga caattcggca gtacgccggc ttcagtactg     1560

tggaggaatc aaacaagttt tataaggaca acatcaaggc tggacagcag ggcctgagtg     1620

tggcattcga tctggccaca catcgcggct atgactcaga taatcccaga gtcagggggg     1680

acgtgggaat ggcaggagtc gctatcgaca cagtggaaga tactaagatt ctgttcgatg     1740

gaatccctct ggagaaaatg tctgtgagta tgacaatgaa cggcgctgtc attcccgtgc     1800

tggcaaactt catcgtcact ggcgaggaac agggggtgcc taaggaaaaa ctgaccggca     1860

caattcagaa cgacatcctg aaggagttca tggtgcggaa tacttacatt tttccccctg     1920

aaccatccat gaaaatcatt gccgatatct tcgagtacac cgctaagcac atgcccaagt     1980

tcaactcaat tagcatctcc gggtatcata tgcaggaagc aggagccgac gctattctgg     2040

agctggctta caccctggca gatggcctgg aatattctcg aaccggactg caggcaggcc     2100

tgacaatcga cgagttcgct cctagactga gtttcttttg gggaattggc atgaactttt     2160

acatggagat cgccaagatg agggctggcc ggagactgtg ggcacacctg atcgagaaga     2220

tgttccagcc taagaactct aagagtctgc tgctgcgggc ccattgccag acatccggct     2280

ggtctctgac tgaacaggac ccatataaca atattgtcag aaccgcaatc gaggcaatgg     2340

cagccgtgtt cggaggaacc cagagcctgc acacaaactc ctttgatgag gccctggggc     2400

tgcctaccgt gaagtctgct aggattgcac gcaatacaca gatcattatc caggaggaat     2460

ccggaatccc aaaggtggcc gatccctggg gaggctctta catgatggag tgcctgacaa     2520

acgacgtgta tgatgctgca ctgaagctga ttaatgaaat cgaggaaatg gggggaatgg     2580

caaaggccgt ggctgagggc attccaaaac tgaggatcga ggaatgtgca gctaggcgcc     2640

aggcacgaat tgactcagga agcgaagtga tcgtcggggt gaataagtac cagctggaga     2700

aagaagacgc agtcgaagtg ctggccatcg ataacacaag cgtgcgcaat cgacagattg     2760

agaagctgaa gaaaatcaaa agctcccgcg atcaggcact ggccgaacga tgcctggcag     2820

ccctgactga gtgtgctgca agcggggacg gaaacattct ggctctggca gtcgatgcct     2880

cccgggctag atgcactgtg ggggaaatca ccgacgccct gaagaaagtc ttcggagagc     2940

acaaggccaa tgatcggatg gtgagcggcg cttatagaca ggagttcggg gaatctaaag     3000

agattaccag tgccatcaag agggtgcaca agttcatgga gagagaaggg cgacggccca     3060

ggctgctggt ggcaaagatg ggacaggacg gacatgatcg cggagcaaaa gtcattgcca     3120

ccgggttcgc tgacctggga tttgacgtgg atatcggccc tctgttccag acaccacgag     3180

aggtcgcaca gcaggcagtc gacgctgatg tgcacgcagt cggagtgtcc actctggcag     3240

ctggccataa gaccctggtg cctgaactga tcaaagagct gaactctctg ggcagaccag     3300

acatcctggt catgtgcggc ggcgtgatcc caccccagga ttacgaattc ctgtttgagg     3360

tcggggtgag caacgtgttc ggaccaggaa ccaggatccc taaggccgca gtgcaggtcc     3420

tggatgatat tgaaaagtgt ctggaaaaga aacagcagtc agtgtaacat cacatttaaa     3480

agcatctcag gtaactatat tttgaatttt ttaaaaaagt aactataata gttattatta     3540

aaatagcaaa gattgaccat ttccaagagc catatagacc agcaccgacc actattctaa     3600

actatttatg tatgtaaata ttagctttta aaattctcaa aatagttgct gagttgggaa     3660

ccactattat ttctattttg tagatgagaa aatgaagata aacatcaaag catagattaa     3720

gtaattttcc aaagggtcaa aattcaaaat tgaaaccaaa gtttcagtgt tgcccattgt     3780

cctgttctga cttatatgat gcggtacaca gagccatcca agtaagtgat ggctcagcag     3840

tggaatactc tgggaattag gctgaaccac atgaaagagt gctttatagg gcaaaaacag     3900

ttgaatatca gtgatttcac atggttcaac ctaatagttc aactcatcct ttccattgga     3960

gaatatgatg gatctacctt ctgtgaactt tatagtgaag aatctgctat tacatttcca     4020

atttgtcaac atgctgagct ttaataggac ttatcttctt atgacaacat ttattggtgt     4080

gtccccttgc ctagcccaac agaagaattc agcagccgta agtctaggac aggcttaaat     4140

tgttttcact ggtgtaaatt gcagaaagat gatctaagta atttggcatt tattttaata     4200

ggtttgaaaa acacatgcca ttttacaaat aagacttata tttgtccttt tgtttttcag     4260

cctaccatga gaataagaga aagaaaatga agatcaaaag cttattcatc tgtttttctt     4320

tttcgttggt gtaaagccaa caccctgtct aaaaaacata aatttcttta atcattttgc     4380

ctcttttctc tgtgcttcaa ttaataaaaa atggaaagaa tctaatagag tggtacagca     4440

ctgttatttt tcaaagatgt gttgtacgta aggaacccct agtgatggag ttggccactc     4500

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4560

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg gccaa          4615


<210>  16
<211>  4619
<212>  DNA
<213>  Mus sp.

<400>  16
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctattta aatctgaaac tagacaaaac ccgtgtgact      180

ggcatcgatt attctatttg atctagctag tcctagcaaa gtgacaactg ctactcccct      240

cctacacagc caagattcct aagttggcag tggcatgctt aatcctcaaa gccaaagtta      300

cttggctcca agatttatag ccttaaactg tggcctcaca ttccttccta tcttactttc      360

ctgcactggg gtaaatgtct ccttgctctt cttgctttct gtcctactgc agggctcttg      420

ctgagctggt gaagcacaag cccaaggcta cagcggagca actgaagact gtcatggatg      480

actttgcaca gttcctggat acatgttgca aggctgctga caaggacacc tgcttctcga      540

ctgaggtcag aaacgttttt gcattttgac gatgttcagt ttccattttc tgtgcacgtg      600

gtcaggtgta gctctctgga actcacacac tgaataactc caccaatcta gatgttgttc      660

tctacgtaac tgtaatagaa actgacttac gtagctttta atttttattt tctgccacac      720

tgctgcctat taaataccta ttatcactat ttggtttcaa atttgtgaca cagaagagca      780

tagttagaaa tacttgcaaa gcctagaatc atgaactcat ttaaaccttg ccctgaaatg      840

tttctttttg aattgagtta ttttacacat gaatggacag ttaccattat atatctgaat      900

catttcacat tccctcccat ggcctaacaa cagtttatct tcttattttg ggcacaacag      960

atgtcagaga gcctgcttta ggaattctaa gtagaactgt aattaagcaa tgcaaggcac     1020

gtacgtttac tatgtcattg cctatggcta tgaagtgcaa atcctaacag tcctgctaat     1080

acttttctaa catccatcat ttctttgttt tcagggtcca aaccttgtca ctagatgcaa     1140

agacgcctta gccggcagcg gcgccaccaa cttcagcctg ctgaaacagg ccggcgacgt     1200

ggaagagaac cctggccccc tgagagccaa aaaccagctg ttcctgctga gcccccacta     1260

tctgagacag gtcaaagaaa gttccgggag tagactgatc cagcagagac tgctgcacca     1320

gcagcagcca ctgcatcctg agtgggccgc tctggccaag aaacagctga agggcaaaaa     1380

cccagaagac ctgatctggc acactccaga ggggatttca atcaagcccc tgtacagcaa     1440

aagggacact atggatctgc cagaggaact gccaggagtg aagcctttca cccgcggacc     1500

ttacccaact atgtatacct ttcgaccctg gacaattcgg cagtacgccg gcttcagtac     1560

tgtggaggaa tcaaacaagt tttataagga caacatcaag gctggacagc agggcctgag     1620

tgtggcattc gatctggcca cacatcgcgg ctatgactca gataatccca gagtcagggg     1680

ggacgtggga atggcaggag tcgctatcga cacagtggaa gatactaaga ttctgttcga     1740

tggaatccct ctggagaaaa tgtctgtgag tatgacaatg aacggcgctg tcattcccgt     1800

gctggcaaac ttcatcgtca ctggcgagga acagggggtg cctaaggaaa aactgaccgg     1860

cacaattcag aacgacatcc tgaaggagtt catggtgcgg aatacttaca tttttccccc     1920

tgaaccatcc atgaaaatca ttgccgatat cttcgagtac accgctaagc acatgcccaa     1980

gttcaactca attagcatct ccgggtatca tatgcaggaa gcaggagccg acgctattct     2040

ggagctggct tacaccctgg cagatggcct ggaatattct cgaaccggac tgcaggcagg     2100

cctgacaatc gacgagttcg ctcctagact gagtttcttt tggggaattg gcatgaactt     2160

ttacatggag atcgccaaga tgagggctgg ccggagactg tgggcacacc tgatcgagaa     2220

gatgttccag cctaagaact ctaagagtct gctgctgcgg gcccattgcc agacatccgg     2280

ctggtctctg actgaacagg acccatataa caatattgtc agaaccgcaa tcgaggcaat     2340

ggcagccgtg ttcggaggaa cccagagcct gcacacaaac tcctttgatg aggccctggg     2400

gctgcctacc gtgaagtctg ctaggattgc acgcaataca cagatcatta tccaggagga     2460

atccggaatc ccaaaggtgg ccgatccctg gggaggctct tacatgatgg agtgcctgac     2520

aaacgacgtg tatgatgctg cactgaagct gattaatgaa atcgaggaaa tggggggaat     2580

ggcaaaggcc gtggctgagg gcattccaaa actgaggatc gaggaatgtg cagctaggcg     2640

ccaggcacga attgactcag gaagcgaagt gatcgtcggg gtgaataagt accagctgga     2700

gaaagaagac gcagtcgaag tgctggccat cgataacaca agcgtgcgca atcgacagat     2760

tgagaagctg aagaaaatca aaagctcccg cgatcaggca ctggccgaac gatgcctggc     2820

agccctgact gagtgtgctg caagcgggga cggaaacatt ctggctctgg cagtcgatgc     2880

ctcccgggct agatgcactg tgggggaaat caccgacgcc ctgaagaaag tcttcggaga     2940

gcacaaggcc aatgatcgga tggtgagcgg cgcttataga caggagttcg gggaatctaa     3000

agagattacc agtgccatca agagggtgca caagttcatg gagagagaag ggcgacggcc     3060

caggctgctg gtggcaaaga tgggacagga cggacatgat cgcggagcaa aagtcattgc     3120

caccgggttc gctgacctgg gatttgacgt ggatatcggc cctctgttcc agacaccacg     3180

agaggtcgca cagcaggcag tcgacgctga tgtgcacgca gtcggagtgt ccactctggc     3240

agctggccat aagaccctgg tgcctgaact gatcaaagag ctgaactctc tgggcagacc     3300

agacatcctg gtcatgtgcg gcggcgtgat cccaccccag gattacgaat tcctgtttga     3360

ggtcggggtg agcaacgtgt tcggaccagg aaccaggatc cctaaggccg cagtgcaggt     3420

cctggatgat attgaaaagt gtctggaaaa gaaacagcag tcagtgtaaa cacatcacaa     3480

ccacaacctt ctcaggtaac tatacttggg acttaaaaaa cataatcata atcatttttc     3540

ctaaaacgat caagactgat aaccatttga caagagccat acagacaagc accagctggc     3600

actcttaggt cttcacgtat ggtcatcagt ttgggttcca tttgtagata agaaactgaa     3660

catataaagg tctaggttaa tgcaatttac acaaaaggag accaaaccag ggagagaagg     3720

aaccaaaatt aaaaattcaa accagagcaa aggagttagc cctggttttg ctctgactta     3780

catgaaccac tatgtggagt cctccatgtt agcctagtca agcttatcct ctggatgaag     3840

ttgaaaccat atgaaggaat atttgggggg tgggtcaaaa cagttgtgta tcaatgattc     3900

catgtggttt gacccaatca ttctgtgaat ccatttcaac agaagataca acgggttctg     3960

tttcataata agtgatccac ttccaaattt ctgatgtgcc ccatgctaag ctttaacaga     4020

atttatcttc ttatgacaaa gcagcctcct ttgaaaatat agccaactgc acacagctat     4080

gttgatcaat tttgtttata atcttgcaga agagaatttt ttaaaatagg gcaataatgg     4140

aaggctttgg caaaaaaatt gtttctccat atgaaaacaa aaaacttatt tttttattca     4200

agcaaagaac ctatagacat aaggctattt caaaattatt tcagttttag aaagaattga     4260

aagttttgta gcattctgag aagacagctt tcatttgtaa tcataggtaa tatgtaggtc     4320

ctcagaaatg gtgagacccc tgactttgac acttggggac tctgagggac cagtgatgaa     4380

gagggcacaa cttatatcac acatgcacga gttggggtga gagggtgtca caacatctat     4440

cagtgtgtca tctgcccacc aagtaaattt aaataggaac ccctagtgat ggagttggcc     4500

actccctctc tgcgcgctcg ctcgctcact gaggccgccc gggcaaagcc cgggcgtcgg     4560

gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaa      4619


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic primer

<400>  17
acattcacct tccatgcaga ta                                                22


<210>  18
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic primer

<400>  18
tcagcaggct gaaattggt                                                    19


<210>  19
<211>  247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(12)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (234)..(234)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (234)..(234)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (243)..(243)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (243)..(243)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (245)..(246)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (245)..(246)
<223>  n is a, c, g, or t

<400>  19
nnnnnnnnnn nngannagan ananaatcaa gaaacaaact gcacttgttg agcttgtgaa       60

acacaagccc aaggcaacaa aanagcaact gaaagctgtt atggatgatt tcgcagcttt      120

tgtagagaag tgctgcaagg ctgacgataa ggagacctgc tttgccgagg agggtaaaaa      180

acttgttgct gcaagtcaag ctgccttagg cttaggcagc ggcgccacca attnagcctg      240

ctnanna                                                                247


