                         SEQUENCE LISTING

<110>  The Board of Regents of the University of Oklahoma
 
<120>  ANTIMALARIAL ENZYME CONJUGATES, KITS CONTAINING SAME, AND METHODS
        OF PRODUCING AND USING SAME

<130>  5835.200wo

<150>  62/543,172
<151>  2017-08-09

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  398
<212>  PRT
<213>  Mus musculus

<400>  1

Met Gln Lys Asp Ala Ser Leu Ser Gly Phe Leu Pro Ser Phe Gln His 
1               5                   10                  15      


Phe Ala Thr Gln Ala Ile His Val Gly Gln Glu Pro Glu Gln Trp Asn 
            20                  25                  30          


Ser Arg Ala Val Val Leu Pro Ile Ser Leu Ala Thr Thr Phe Lys Gln 
        35                  40                  45              


Asp Phe Pro Gly Gln Ser Ser Gly Phe Glu Tyr Ser Arg Ser Gly Asn 
    50                  55                  60                  


Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly Ala 
65                  70                  75                  80  


Lys His Ser Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Ile Thr Ile 
                85                  90                  95      


Thr His Leu Leu Lys Ala Gly Asp Glu Ile Ile Cys Met Asp Glu Val 
            100                 105                 110         


Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Arg Val Ala Ser Glu Phe Gly 
        115                 120                 125             


Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Thr Lys Leu Leu Glu Ala 
    130                 135                 140                 


Ala Ile Thr Pro Gln Thr Lys Leu Val Trp Ile Glu Thr Pro Thr Asn 
145                 150                 155                 160 


Pro Thr Leu Lys Leu Ala Asp Ile Gly Ala Cys Ala Gln Ile Val His 
                165                 170                 175     


Lys Arg Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser Ala 
            180                 185                 190         


Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Cys Ser 
        195                 200                 205             


Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu Val 
    210                 215                 220                 


Ser Val Asn Ser Asp Asp Leu Asn Ser Arg Leu Arg Phe Leu Gln Asn 
225                 230                 235                 240 


Ser Leu Gly Ala Val Pro Ser Pro Phe Asp Cys Tyr Leu Cys Cys Arg 
                245                 250                 255     


Gly Leu Lys Thr Leu Gln Val Arg Met Glu Lys His Phe Lys Asn Gly 
            260                 265                 270         


Met Ala Val Ala Arg Phe Leu Glu Thr Asn Pro Arg Val Glu Lys Val 
        275                 280                 285             


Val Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Ala Lys Arg 
    290                 295                 300                 


Gln Cys Ser Gly Cys Pro Gly Met Val Ser Phe Tyr Ile Lys Gly Ala 
305                 310                 315                 320 


Leu Gln His Ala Lys Ala Phe Leu Lys Asn Leu Lys Leu Phe Thr Leu 
                325                 330                 335     


Ala Glu Ser Leu Gly Gly Tyr Glu Ser Leu Ala Glu Leu Pro Ala Ile 
            340                 345                 350         


Met Thr His Ala Ser Val Pro Glu Lys Asp Arg Ala Thr Leu Gly Ile 
        355                 360                 365             


Asn Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Gln Asp 
    370                 375                 380                 


Leu Leu Glu Asp Leu Asp Arg Ala Leu Lys Ala Ala His Pro 
385                 390                 395             


<210>  2
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210>  3
<211>  398
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant of SEQ ID NO:1

<400>  3

Met Gln Lys Asp Ala Ser Leu Ser Gly Phe Leu Pro Ser Phe Gln His 
1               5                   10                  15      


Phe Ala Thr Gln Ala Ile His Val Gly Gln Glu Pro Glu Gln Trp Asn 
            20                  25                  30          


Ser Arg Ala Val Val Leu Pro Ile Ser Leu Ala Thr Thr Phe Lys Gln 
        35                  40                  45              


Asp Phe Pro Gly Gln Ser Ser Gly Phe Asn Tyr Ser Arg Ser Gly Asn 
    50                  55                  60                  


Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly Ala 
65                  70                  75                  80  


Lys His Ser Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Ile Thr Ile 
                85                  90                  95      


Thr His Leu Leu Lys Ala Gly Asp Glu Ile Ile Cys Met Asp Glu Val 
            100                 105                 110         


Tyr Gly Gly Thr Asn Leu Tyr Phe Arg Arg Val Ala Ser Glu Phe Gly 
        115                 120                 125             


Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Thr Lys Leu Leu Glu Ala 
    130                 135                 140                 


Ala Ile Thr Pro Gln Thr Lys Leu Val Trp Ile Glu Thr Pro Thr Asn 
145                 150                 155                 160 


Pro Thr Leu Lys Leu Ala Asp Ile Gly Ala Cys Ala Gln Ile Val His 
                165                 170                 175     


Lys Arg Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser Ala 
            180                 185                 190         


Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Cys Ser 
        195                 200                 205             


Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu Val 
    210                 215                 220                 


Ser Val Asn Ser Asp Asp Leu Asn Ser Arg Leu Arg Phe Leu Gln Asn 
225                 230                 235                 240 


Ser Leu Gly Ala Val Pro Ser Pro Phe Asp Cys Tyr Leu Cys Cys Arg 
                245                 250                 255     


Gly Leu Lys Thr Leu Gln Val Arg Met Glu Lys His Phe Lys Asn Gly 
            260                 265                 270         


Met Ala Val Ala Arg Phe Leu Glu Thr Asn Pro Arg Val Glu Lys Val 
        275                 280                 285             


Val Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Ala Lys Arg 
    290                 295                 300                 


Gln Cys Ser Gly Cys Pro Gly Met Val Ser Phe Tyr Ile Lys Gly Ala 
305                 310                 315                 320 


Leu Gln His Ala Lys Ala Phe Leu Lys Asn Leu Lys Leu Phe Thr Leu 
                325                 330                 335     


Ala Val Ser Leu Gly Gly Tyr Glu Ser Leu Ala Glu Leu Pro Ala Ile 
            340                 345                 350         


Met Thr His Ala Ser Val Pro Glu Lys Asp Arg Ala Thr Leu Gly Ile 
        355                 360                 365             


Asn Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Gln Asp 
    370                 375                 380                 


Leu Leu Glu Asp Leu Asp Arg Ala Leu Lys Ala Ala His Pro 
385                 390                 395             


<210>  4
<211>  405
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant of SEQ ID NO:2

<400>  4

Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Asn Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Leu Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


