                         SEQUENCE LISTING

<110>  Medannex Ltd.
 
<120>  Cancer Treatment with an Antibody

<130>  42.18.139574/03

<150>  GB 1813137.5
<151>  2018-08-10

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLCDR1 of L1M2H4 and L2M2H2

<400>  1

Arg Ser Ser Gln Ser Leu Glu Asn Ser Asn Ala Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLCDR2 of Mdx001, L1M2H4 and L2M2H2

<400>  2

Gly Val Ser Asn Arg Phe Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLCDR3 of Mdx001, L1M2H4 and L2M2H2

<400>  3

Leu Gln Val Thr His Val Pro Tyr Thr 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHCDR1 of Mdx001, L1M2H4 and L2M2H2

<400>  4

Gly Tyr Thr Phe Thr Asn Tyr Trp Ile Gly 
1               5                   10  


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHCDR2 of Mdx001, L1M2H4 and L2M2H2

<400>  5

Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHCDR3 of Mdx001, L1M2H4 and L2M2H2

<400>  6

Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLCDR1 of Mdx001

<400>  7

Arg Ser Ser Gln Ser Leu Glu Asn Ser Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLCDR1 variant with S9T substitution

<400>  8

Arg Ser Ser Gln Ser Leu Glu Asn Thr Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  9
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L1M2 light chain variable region

<400>  9

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Ala Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  10
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L2M2 light chain variable region

<400>  10

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Ala Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  11
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H4 heavy chain variable region

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  12
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 heavy chain variable region

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  13
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L1M2 light chain

<400>  13

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Ala Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  14
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H4 heavy chain

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  15
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L2M2 light chain

<400>  15

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Ala Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  16
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 heavy chain

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  17
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  18
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asn Leu Ile Leu Arg Tyr Thr Phe Ser Lys Met Ala Met Val Ser 
1               5                   10                  15      


Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn Glu Glu Gln Glu Tyr 
            20                  25                  30          


Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro Gly Ser Ala Val Ser 
        35                  40                  45              


Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val Ala Ala Leu His Lys 
    50                  55                  60                  


Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr Ile Ile Asp Ile Leu 
65                  70                  75                  80  


Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile Lys Ala Ala Tyr Leu 
                85                  90                  95      


Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu Lys Lys Ala Leu Thr 
            100                 105                 110         


Gly His Leu Glu Glu Val Val Leu Ala Leu Leu Lys Thr Pro Ala Gln 
        115                 120                 125             


Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys Gly Leu Gly Thr Asp 
    130                 135                 140                 


Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Lys Glu Ile 
145                 150                 155                 160 


Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu Lys Arg Asp Leu Ala 
                165                 170                 175     


Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe Arg Asn Ala Leu Leu 
            180                 185                 190         


Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe Gly 
        195                 200                 


<210>  19
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro 
        115 


<210>  20
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain signal sequence

<400>  20

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys 
            20  


<210>  21
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain signal sequence

<400>  21

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  22
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L1M2 light chain pro sequence

<400>  22

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Glu Asn Ser Asn Ala Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr Gly Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe 
            100                 105                 110         


Cys Leu Gln Val Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  23
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H4 heavy chain pro sequence

<400>  23

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  24
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L2M2 light chain pro sequence

<400>  24

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Glu Asn Ser Asn Ala Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Val Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  25
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 heavy chain pro sequence

<400>  25

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  26
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L1M2 light chain pro sequence

<400>  26
atggtgtcat ccgctcaatt tctcggtttg cttctcctgt gtttccaagg cacccgctgc       60

gacgtggtca tgacccagag cccactgagc cttccggtca ccttgggaca gcccgcctca      120

atttcatgcc ggtccagcca gtccctggag aactccaacg ccaagaccta tctgaactgg      180

ttccagcagc gccctggaca gtccccgagg cgcctgatct acggcgtcag caacaggttc      240

tcgggcgtgc cggacagatt ctccggctcc ggaagcggaa ctgacttcac cctgaaaatc      300

tcaagagtgg aagccgagga cgtgggcgtg tacttctgcc tccaagtcac gcacgtgccg      360

tacactttcg gacaagggac taagctggag atcaagcgga ccgtggcggc cccctctgtg      420

ttcattttcc ctccctcgga cgaacagctg aagtcgggaa cagcctccgt cgtgtgcctg      480

ctcaacaact tctacccccg ggaagcgaag gtccagtgga aagtggataa cgcactccaa      540

tcggggaact cccaggaatc cgtgactgag caggactcga aggattccac ttactccctg      600

tcgtccaccc tgactctgag caaggccgac tacgagaagc ataaggtcta cgcctgcgaa      660

gtgacccacc agggtctgag ctcccctgtg accaagagct ttaatcgggg cgaatgttga      720


<210>  27
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H4 heavy chain pro sequence

<400>  27
atgggatgga ctctcgtgtt cctttttctc ctctctgtca ctgccggggt gcattcgcaa       60

gtccagctgg tgcagtcggg agcagaggtg aaaaagcccg gatcgtcagt gaaggtcagc      120

tgcaaagcct cgggatacac tttcaccaac tactggattg gatgggtcag acaggccccc      180

ggccaaggac tggagtgggt cggcgacatc taccctgggg gcgactatac caactacaac      240

gaaaagttca agggacgcgt gacaattacc gccgataaga gcaccagcac tgcctacatg      300

gagcttagct cattgcggtc cgaggatacc gctgtgtact actgtgcgcg gtggggcctt      360

ggttactact tcgactactg gggacagggt accatggtca cggtgtcctc cgcgtccacc      420

aagggtccct ccgtgttccc tctcgcgccg tcctcaaagt ctacctccgg tggaactgcc      480

gcgctcggtt gtctcgtgaa ggactacttc ccggagcctg tgactgtctc ctggaactcc      540

ggggccctca ccagcggagt gcacactttc cccgccgtgc tgcaatcctc cggcctgtac      600

agcctgtcct ccgtcgtgac tgtgcctagc tcctccctgg gaacccagac ctacatctgc      660

aacgtgaacc acaagccctc caacaccaag gtcgacaaga aggtcgaacc gaagtcgtgc      720

gacaagactc atacgtgccc tccttgcccg gccccggaac tgctgggagg cccatccgtg      780

ttcctgttcc cacccaagcc taaggatacc ctgatgatca gcagaacacc ggaagtgacc      840

tgtgtggtgg tggacgtcag ccacgaagat cccgaggtca agttcaattg gtacgtggac      900

ggggtggagg tgcacaacgc aaagaccaag ccccgggagg aacagtacaa ctccacctat      960

cgcgtggtgt cggtgctgac ggtgctgcac caggactggt tgaacggaaa ggagtataag     1020

tgcaaagtgt cgaacaaggc cctgcccgct cctatcgaaa agaccatctc caaggccaag     1080

ggccagccgc gggaacccca ggtctacact ctcccaccga gccgcgacga actgactaag     1140

aatcaagtgt cgctgacttg cctcgtcaag ggcttctacc cgtccgacat cgccgtggaa     1200

tgggagagca acggccagcc ggaaaacaac tacaagacca cccctcccgt gctggattcc     1260

gacgggtcct tcttcctgta ctcaaaactg accgtggata agtccagatg gcagcagggc     1320

aatgtctttt catgctccgt gatgcacgag gctctgcata accactacac ccagaagtcg     1380

ctgtccctgt ccccggggaa gtga                                            1404


<210>  28
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L2M2 light chain pro sequence

<400>  28
atggtgtcat ccgctcaatt tctcggtttg cttctcctgt gtttccaagg cacccgctgc       60

gacatcgtca tgacccagac cccattgagc ctttccgtca cgccgggaca gcccgcctcc      120

atttcctgcc gctcaagcca gtccctggag aactcaaacg ccaagaccta cctgaattgg      180

tatctgcaga agcctggaca gagcccgcag ctgctgatct acggcgtcag caacaggttc      240

tcgggcgtgc cggacagatt ctccggctcc ggaagcggaa ctgacttcac cctgaaaatc      300

tcacgcgtgg aagccgagga cgtgggcgtg tactactgcc tccaagtcac ccacgtgccg      360

tacactttcg gacaagggac taaggtcgag atcaagcgga ccgtggcggc cccctctgtg      420

ttcattttcc ctccctcgga cgaacagctg aagtcgggaa cagcctccgt cgtgtgcctg      480

ctcaacaact tctacccccg ggaagcgaag gtccagtgga aagtggataa cgcactccaa      540

tcggggaact cccaggaatc cgtgactgag caggactcga aggattccac ttactccctg      600

tcgtccaccc tgactctgag caaggccgac tacgagaagc ataaggtcta cgcctgcgaa      660

gtgacccacc agggtctgag ctcccctgtg accaagagct ttaatcgggg cgaatgttga      720


<210>  29
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H2 heavy chain pro sequence

<400>  29
atgggatgga ctctcgtgtt cctttttctc ctctctgtca ctgccggggt gcattcgcaa       60

gtccagctgg tgcagtcggg accagaggtg aaaaagcccg gagagtcact taagatcagc      120

tgcaaaggct cgggatacac tttcaccaac tactggattg gttgggtcag acaggccccc      180

ggcaaaggac tggagtggat gggcgacatc taccctgggg gcgactatac caactacaac      240

gaaaagttca agggacaagt gacaatttcg gccgataaga gcattagcac tgcatacctt      300

cagtggagct cattgaaggc ctccgatacc gctatctact actgtgcgcg gtggggcctg      360

ggatactact tcgactactg gggaaggggt accttggtca cggtgtcctc cgcgtccacc      420

aagggtccct ccgtgttccc tctcgcgccg tcctcaaagt ctacctccgg tggaactgcc      480

gcgctcggtt gtctcgtgaa ggactacttc ccggagcctg tgactgtctc ctggaactcc      540

ggggccctca ccagcggagt gcacactttc cccgccgtgc tgcaatcctc cggcctgtac      600

agcctgtcct ccgtcgtgac tgtgcctagc tcctccctgg gaacccagac ctacatctgc      660

aacgtgaacc acaagccctc caacaccaag gtcgacaaga aggtcgaacc gaagtcgtgc      720

gacaagactc atacgtgccc tccttgcccg gccccggaac tgctgggagg cccatccgtg      780

ttcctgttcc cacccaagcc taaggatacc ctgatgatca gcagaacacc ggaagtgacc      840

tgtgtggtgg tggacgtcag ccacgaagat cccgaggtca agttcaattg gtacgtggac      900

ggggtggagg tgcacaacgc aaagaccaag ccccgggagg aacagtacaa ctccacctat      960

cgcgtggtgt cggtgctgac ggtgctgcac caggactggt tgaacggaaa ggagtataag     1020

tgcaaagtgt cgaacaaggc cctgcccgct cctatcgaaa agaccatctc caaggccaag     1080

ggccagccgc gggaacccca ggtctacact ctcccaccga gccgcgacga actgactaag     1140

aatcaagtgt cgctgacttg cctcgtcaag ggcttctacc cgtccgacat cgccgtggaa     1200

tgggagagca acggccagcc ggaaaacaac tacaagacca cccctcccgt gctggattcc     1260

gacgggtcct tcttcctgta ctcaaaactg accgtggata agtccagatg gcagcagggc     1320

aatgtctttt catgctccgt gatgcacgag gctctgcata accactacac ccagaagtcg     1380

ctgtccctgt ccccggggaa gtga                                            1404


<210>  30
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn Glu Glu 
1               5                   10                  15      


Gln Glu Tyr Val Gln Thr 
            20          


<210>  31
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  31

Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn Glu 
1               5                   10                  15      


Glu Gln Glu Tyr Val Gln Thr Val Lys 
            20                  25  


