                         SEQUENCE LISTING

<110>  PIQUR Therapeutics AG
 
<120>  TREATMENT OF SQUAMOUS CELL CARCINOMA

<130>  P5508PC00

<150>  US62/715,634
<151>  2018-08-07

<150>  EP18212447.9
<151>  2018-12-13

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  7668
<212>  DNA
<213>  homo sapiens

<400>  1
atgccgccgc tcctggcgcc cctgctctgc ctggcgctgc tgcccgcgct cgccgcacga       60

ggcccgcgat gctcccagcc cggtgagacc tgcctgaatg gcgggaagtg tgaagcggcc      120

aatggcacgg aggcctgcgt ctgtggcggg gccttcgtgg gcccgcgatg ccaggacccc      180

aacccgtgcc tcagcacccc ctgcaagaac gccgggacat gccacgtggt ggaccgcaga      240

ggcgtggcag actatgcctg cagctgtgcc ctgggcttct ctgggcccct ctgcctgaca      300

cccctggaca atgcctgcct caccaacccc tgccgcaacg ggggcacctg cgacctgctc      360

acgctgacgg agtacaagtg ccgctgcccg cccggctggt cagggaaatc gtgccagcag      420

gctgacccgt gcgcctccaa cccctgcgcc aacggtggcc agtgcctgcc cttcgaggcc      480

tcctacatct gccactgccc acccagcttc catggcccca cctgccggca ggatgtcaac      540

gagtgtggcc agaagcccgg gctttgccgc cacggaggca cctgccacaa cgaggtcggc      600

tcctaccgct gcgtctgccg cgccacccac actggcccca actgcgagcg gccctacgtg      660

ccctgcagcc cctcgccctg ccagaacggg ggcacctgcc gccccacggg cgacgtcacc      720

cacgagtgtg cctgcctgcc aggcttcacc ggccagaact gtgaggaaaa tatcgacgat      780

tgtccaggaa acaactgcaa gaacgggggt gcctgtgtgg acggcgtgaa cacctacaac      840

tgccgctgcc cgccagagtg gacaggtcag tactgtaccg aggatgtgga cgagtgccag      900

ctgatgccaa atgcctgcca gaacggcggg acctgccaca acacccacgg tggctacaac      960

tgcgtgtgtg tcaacggctg gactggtgag gactgcagcg agaacattga tgactgtgcc     1020

agcgccgcct gcttccacgg cgccacctgc catgaccgtg tggcctcctt ctactgcgag     1080

tgtccccatg gccgcacagg tctgctgtgc cacctcaacg acgcatgcat cagcaacccc     1140

tgtaacgagg gctccaactg cgacaccaac cctgtcaatg gcaaggccat ctgcacctgc     1200

ccctcggggt acacgggccc ggcctgcagc caggacgtgg atgagtgctc gctgggtgcc     1260

aacccctgcg agcatgcggg caagtgcatc aacacgctgg gctccttcga gtgccagtgt     1320

ctgcagggct acacgggccc ccgatgcgag atcgacgtca acgagtgcgt ctcgaacccg     1380

tgccagaacg acgccacctg cctggaccag attggggagt tccagtgcat ctgcatgccc     1440

ggctacgagg gtgtgcactg cgaggtcaac acagacgagt gtgccagcag cccctgcctg     1500

cacaatggcc gctgcctgga caagatcaat gagttccagt gcgagtgccc cacgggcttc     1560

actgggcatc tgtgccagta cgatgtggac gagtgtgcca gcaccccctg caagaatggt     1620

gccaagtgcc tggacggacc caacacttac acctgtgtgt gcacggaagg gtacacgggg     1680

acgcactgcg aggtggacat cgatgagtgc gaccccgacc cctgccacta cggctcctgc     1740

aaggacggcg tcgccacctt cacctgcctc tgccgcccag gctacacggg ccaccactgc     1800

gagaccaaca tcaacgagtg ctccagccag ccctgccgcc acgggggcac ctgccaggac     1860

cgcgacaacg cctacctctg cttctgcctg aaggggacca caggacccaa ctgcgagatc     1920

aacctggatg actgtgccag cagcccctgc gactcgggca cctgtctgga caagatcgat     1980

ggctacgagt gtgcctgtga gccgggctac acagggagca tgtgtaacat caacatcgat     2040

gagtgtgcgg gcaacccctg ccacaacggg ggcacctgcg aggacggcat caatggcttc     2100

acctgccgct gccccgaggg ctaccacgac cccacctgcc tgtctgaggt caatgagtgc     2160

aacagcaacc cctgcgtcca cggggcctgc cgggacagcc tcaacgggta caagtgcgac     2220

tgtgaccctg ggtggagtgg gaccaactgt gacatcaaca acaatgagtg tgaatccaac     2280

ccttgtgtca acggcggcac ctgcaaagac atgaccagtg gctacgtgtg cacctgccgg     2340

gagggcttca gcggtcccaa ctgccagacc aacatcaacg agtgtgcgtc caacccatgt     2400

ctgaaccagg gcacgtgtat tgacgacgtt gccgggtaca agtgcaactg cctgctgccc     2460

tacacaggtg ccacgtgtga ggtggtgctg gccccgtgtg cccccagccc ctgcagaaac     2520

ggcggggagt gcaggcaatc cgaggactat gagagcttct cctgtgtctg ccccacgggc     2580

tggcaagggc agacctgtga ggtcgacatc aacgagtgcg ttctgagccc gtgccggcac     2640

ggcgcatcct gccagaacac ccacggcggc taccgctgcc actgccaggc cggctacagt     2700

gggcgcaact gcgagaccga catcgacgac tgccggccca acccgtgtca caacgggggc     2760

tcctgcacag acggcatcaa cacggccttc tgcgactgcc tgcccggctt ccggggcact     2820

ttctgtgagg aggacatcaa cgagtgtgcc agtgacccct gccgcaacgg ggccaactgc     2880

acggactgcg tggacagcta cacgtgcacc tgccccgcag gcttcagcgg gatccactgt     2940

gagaacaaca cgcctgactg cacagagagc tcctgcttca acggtggcac ctgcgtggac     3000

ggcatcaact cgttcacctg cctgtgtcca cccggcttca cgggcagcta ctgccagcac     3060

gatgtcaatg agtgcgactc acagccctgc ctgcatggcg gcacctgtca ggacggctgc     3120

ggctcctaca ggtgcacctg cccccagggc tacactggcc ccaactgcca gaaccttgtg     3180

cactggtgtg actcctcgcc ctgcaagaac ggcggcaaat gctggcagac ccacacccag     3240

taccgctgcg agtgccccag cggctggacc ggcctttact gcgacgtgcc cagcgtgtcc     3300

tgtgaggtgg ctgcgcagcg acaaggtgtt gacgttgccc gcctgtgcca gcatggaggg     3360

ctctgtgtgg acgcgggcaa cacgcaccac tgccgctgcc aggcgggcta cacaggcagc     3420

tactgtgagg acctggtgga cgagtgctca cccagcccct gccagaacgg ggccacctgc     3480

acggactacc tgggcggcta ctcctgcaag tgcgtggccg gctaccacgg ggtgaactgc     3540

tctgaggaga tcgacgagtg cctctcccac ccctgccaga acgggggcac ctgcctcgac     3600

ctccccaaca cctacaagtg ctcctgccca cggggcactc agggtgtgca ctgtgagatc     3660

aacgtggacg actgcaatcc ccccgttgac cccgtgtccc ggagccccaa gtgctttaac     3720

aacggcacct gcgtggacca ggtgggcggc tacagctgca cctgcccgcc gggcttcgtg     3780

ggtgagcgct gtgaggggga tgtcaacgag tgcctgtcca atccctgcga cgcccgtggc     3840

acccagaact gcgtgcagcg cgtcaatgac ttccactgcg agtgccgtgc tggtcacacc     3900

gggcgccgct gcgagtccgt catcaatggc tgcaaaggca agccctgcaa gaatgggggc     3960

acctgcgccg tggcctccaa caccgcccgc gggttcatct gcaagtgccc tgcgggcttc     4020

gagggcgcca cgtgtgagaa tgacgctcgt acctgcggca gcctgcgctg cctcaacggc     4080

ggcacatgca tctccggccc gcgcagcccc acctgcctgt gcctgggccc cttcacgggc     4140

cccgaatgcc agttcccggc cagcagcccc tgcctgggcg gcaacccctg ctacaaccag     4200

gggacctgtg agcccacatc cgagagcccc ttctaccgtt gcctgtgccc cgccaaattc     4260

aacgggctct tgtgccacat cctggactac agcttcgggg gtggggccgg gcgcgacatc     4320

cccccgccgc tgatcgagga ggcgtgcgag ctgcccgagt gccaggagga cgcgggcaac     4380

aaggtctgca gcctgcagtg caacaaccac gcgtgcggct gggacggcgg tgactgctcc     4440

ctcaacttca atgacccctg gaagaactgc acgcagtctc tgcagtgctg gaagtacttc     4500

agtgacggcc actgtgacag ccagtgcaac tcagccggct gcctcttcga cggctttgac     4560

tgccagcgtg cggaaggcca gtgcaacccc ctgtacgacc agtactgcaa ggaccacttc     4620

agcgacgggc actgcgacca gggctgcaac agcgcggagt gcgagtggga cgggctggac     4680

tgtgcggagc atgtacccga gaggctggcg gccggcacgc tggtggtggt ggtgctgatg     4740

ccgccggagc agctgcgcaa cagctccttc cacttcctgc gggagctcag ccgcgtgctg     4800

cacaccaacg tggtcttcaa gcgtgacgca cacggccagc agatgatctt cccctactac     4860

ggccgcgagg aggagctgcg caagcacccc atcaagcgtg ccgccgaggg ctgggccgca     4920

cctgacgccc tgctgggcca ggtgaaggcc tcgctgctcc ctggtggcag cgagggtggg     4980

cggcggcgga gggagctgga ccccatggac gtccgcggct ccatcgtcta cctggagatt     5040

gacaaccggc agtgtgtgca ggcctcctcg cagtgcttcc agagtgccac cgacgtggcc     5100

gcattcctgg gagcgctcgc ctcgctgggc agcctcaaca tcccctacaa gatcgaggcc     5160

gtgcagagtg agaccgtgga gccgcccccg ccggcgcagc tgcacttcat gtacgtggcg     5220

gcggccgcct ttgtgcttct gttcttcgtg ggctgcgggg tgctgctgtc ccgcaagcgc     5280

cggcggcagc atggccagct ctggttccct gagggcttca aagtgtctga ggccagcaag     5340

aagaagcggc gggagcccct cggcgaggac tccgtgggcc tcaagcccct gaagaacgct     5400

tcagacggtg ccctcatgga cgacaaccag aatgagtggg gggacgagga cctggagacc     5460

aagaagttcc ggttcgagga gcccgtggtt ctgcctgacc tggacgacca gacagaccac     5520

cggcagtgga ctcagcagca cctggatgcc gctgacctgc gcatgtctgc catggccccc     5580

acaccgcccc agggtgaggt tgacgccgac tgcatggacg tcaatgtccg cgggcctgat     5640

ggcttcaccc cgctcatgat cgcctcctgc agcgggggcg gcctggagac gggcaacagc     5700

gaggaagagg aggacgcgcc ggccgtcatc tccgacttca tctaccaggg cgccagcctg     5760

cacaaccaga cagaccgcac gggcgagacc gccttgcacc tggccgcccg ctactcacgc     5820

tctgatgccg ccaagcgcct gctggaggcc agcgcagatg ccaacatcca ggacaacatg     5880

ggccgcaccc cgctgcatgc ggctgtgtct gccgacgcac aaggtgtctt ccagatcctg     5940

atccggaacc gagccacaga cctggatgcc cgcatgcatg atggcacgac gccactgatc     6000

ctggctgccc gcctggccgt ggagggcatg ctggaggacc tcatcaactc acacgccgac     6060

gtcaacgccg tagatgacct gggcaagtcc gccctgcact gggccgccgc cgtgaacaat     6120

gtggatgccg cagttgtgct cctgaagaac ggggctaaca aagatatgca gaacaacagg     6180

gaggagacac ccctgtttct ggccgcccgg gagggcagct acgagaccgc caaggtgctg     6240

ctggaccact ttgccaaccg ggacatcacg gatcatatgg accgcctgcc gcgcgacatc     6300

gcacaggagc gcatgcatca cgacatcgtg aggctgctgg acgagtacaa cctggtgcgc     6360

agcccgcagc tgcacggagc cccgctgggg ggcacgccca ccctgtcgcc cccgctctgc     6420

tcgcccaacg gctacctggg cagcctcaag cccggcgtgc agggcaagaa ggtccgcaag     6480

cccagcagca aaggcctggc ctgtggaagc aaggaggcca aggacctcaa ggcacggagg     6540

aagaagtccc aggacggcaa gggctgcctg ctggacagct ccggcatgct ctcgcccgtg     6600

gactccctgg agtcacccca tggctacctg tcagacgtgg cctcgccgcc actgctgccc     6660

tccccgttcc agcagtctcc gtccgtgccc ctcaaccacc tgcctgggat gcccgacacc     6720

cacctgggca tcgggcacct gaacgtggcg gccaagcccg agatggcggc gctgggtggg     6780

ggcggccggc tggcctttga gactggccca cctcgtctct cccacctgcc tgtggcctct     6840

ggcaccagca ccgtcctggg ctccagcagc ggaggggccc tgaatttcac tgtgggcggg     6900

tccaccagtt tgaatggtca atgcgagtgg ctgtcccggc tgcagagcgg catggtgccg     6960

aaccaataca accctctgcg ggggagtgtg gcaccaggcc ccctgagcac acaggccccc     7020

tccctgcagc atggcatggt aggcccgctg cacagtagcc ttgctgccag cgccctgtcc     7080

cagatgatga gctaccaggg cctgcccagc acccggctgg ccacccagcc tcacctggtg     7140

cagacccagc aggtgcagcc acaaaactta cagatgcagc agcagaacct gcagccagca     7200

aacatccagc agcagcaaag cctgcagccg ccaccaccac caccacagcc gcaccttggc     7260

gtgagctcag cagccagcgg ccacctgggc cggagcttcc tgagtggaga gccgagccag     7320

gcagacgtgc agccactggg ccccagcagc ctggcggtgc acactattct gccccaggag     7380

agccccgccc tgcccacgtc gctgccatcc tcgctggtcc cacccgtgac cgcagcccag     7440

ttcctgacgc ccccctcgca gcacagctac tcctcgcctg tggacaacac ccccagccac     7500

cagctacagg tgcctgagca ccccttcctc accccgtccc ctgagtcccc tgaccagtgg     7560

tccagctcgt ccccgcattc caacgtctcc gactggtccg agggcgtctc cagccctccc     7620

accagcatgc agtcccagat cgcccgcatt ccggaggcct tcaagtaa                  7668


<210>  2
<211>  2555
<212>  PRT
<213>  homosapiens

<400>  2

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg 
65                  70                  75                  80  


Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala 
145                 150                 155                 160 


Ser Tyr Ile Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Gly Gln Lys Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala 
    610                 615                 620                 


Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln 
                885                 890                 895     


Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln His  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Gln Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Gly Cys  Gly Ser Tyr Arg Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Pro Asn  Cys Gln Asn Leu Val  His Trp Cys Asp Ser  Ser Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Lys Cys Trp  Gln Thr His Thr Gln  Tyr Arg Cys 
    1070                 1075                 1080             


Glu Cys  Pro Ser Gly Trp Thr  Gly Leu Tyr Cys Asp  Val Pro Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Arg Gln Gly Val  Asp Val Ala 
    1100                 1105                 1110             


Arg Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Ala  Gly Asn Thr 
    1115                 1120                 1125             


His His  Cys Arg Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Leu  Val Asp Glu Cys Ser  Pro Ser Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Tyr Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Val Asn Cys  Ser Glu Glu Ile Asp  Glu Cys Leu 
    1175                 1180                 1185             


Ser His  Pro Cys Gln Asn Gly  Gly Thr Cys Leu Asp  Leu Pro Asn 
    1190                 1195                 1200             


Thr Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  Asn Pro Pro Val Asp  Pro Val Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Ser Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Ala 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Lys Gly Lys Pro  Cys Lys Asn Gly Gly  Thr Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Lys  Cys Pro Ala 
    1325                 1330                 1335             


Gly Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Pro Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Leu Gly Gly Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Ser Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Gly Gly Gly  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Leu Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Glu Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Ser Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Arg Ala Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Val Val Val 
    1565                 1570                 1575             


Leu Met  Pro Pro Glu Gln Leu  Arg Asn Ser Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Glu  Leu Ser Arg Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  His Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly Arg Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ala Ala  Glu Gly Trp 
    1625                 1630                 1635             


Ala Ala  Pro Asp Ala Leu Leu  Gly Gln Val Lys Ala  Ser Leu Leu 
    1640                 1645                 1650             


Pro Gly  Gly Ser Glu Gly Gly  Arg Arg Arg Arg Glu  Leu Asp Pro 
    1655                 1660                 1665             


Met Asp  Val Arg Gly Ser Ile  Val Tyr Leu Glu Ile  Asp Asn Arg 
    1670                 1675                 1680             


Gln Cys  Val Gln Ala Ser Ser  Gln Cys Phe Gln Ser  Ala Thr Asp 
    1685                 1690                 1695             


Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser Leu Gly  Ser Leu Asn 
    1700                 1705                 1710             


Ile Pro  Tyr Lys Ile Glu Ala  Val Gln Ser Glu Thr  Val Glu Pro 
    1715                 1720                 1725             


Pro Pro  Pro Ala Gln Leu His  Phe Met Tyr Val Ala  Ala Ala Ala 
    1730                 1735                 1740             


Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly Val Leu  Leu Ser Arg 
    1745                 1750                 1755             


Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp Phe Pro  Glu Gly Phe 
    1760                 1765                 1770             


Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg Arg Glu  Pro Leu Gly 
    1775                 1780                 1785             


Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys Asn Ala  Ser Asp Gly 
    1790                 1795                 1800             


Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp Gly Asp  Glu Asp Leu 
    1805                 1810                 1815             


Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro Val Val  Leu Pro Asp 
    1820                 1825                 1830             


Leu Asp  Asp Gln Thr Asp His  Arg Gln Trp Thr Gln  Gln His Leu 
    1835                 1840                 1845             


Asp Ala  Ala Asp Leu Arg Met  Ser Ala Met Ala Pro  Thr Pro Pro 
    1850                 1855                 1860             


Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp Val Asn  Val Arg Gly 
    1865                 1870                 1875             


Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala Ser Cys  Ser Gly Gly 
    1880                 1885                 1890             


Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu Glu Asp  Ala Pro Ala 
    1895                 1900                 1905             


Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala Ser Leu  His Asn Gln 
    1910                 1915                 1920             


Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His Leu Ala  Ala Arg Tyr 
    1925                 1930                 1935             


Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu Glu Ala  Ser Ala Asp 
    1940                 1945                 1950             


Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr Pro Leu  His Ala Ala 
    1955                 1960                 1965             


Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln Ile Leu  Ile Arg Asn 
    1970                 1975                 1980             


Arg Ala  Thr Asp Leu Asp Ala  Arg Met His Asp Gly  Thr Thr Pro 
    1985                 1990                 1995             


Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu Gly Met  Leu Glu Asp 
    2000                 2005                 2010             


Leu Ile  Asn Ser His Ala Asp  Val Asn Ala Val Asp  Asp Leu Gly 
    2015                 2020                 2025             


Lys Ser  Ala Leu His Trp Ala  Ala Ala Val Asn Asn  Val Asp Ala 
    2030                 2035                 2040             


Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn Lys Asp  Met Gln Asn 
    2045                 2050                 2055             


Asn Arg  Glu Glu Thr Pro Leu  Phe Leu Ala Ala Arg  Glu Gly Ser 
    2060                 2065                 2070             


Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His Phe Ala  Asn Arg Asp 
    2075                 2080                 2085             


Ile Thr  Asp His Met Asp Arg  Leu Pro Arg Asp Ile  Ala Gln Glu 
    2090                 2095                 2100             


Arg Met  His His Asp Ile Val  Arg Leu Leu Asp Glu  Tyr Asn Leu 
    2105                 2110                 2115             


Val Arg  Ser Pro Gln Leu His  Gly Ala Pro Leu Gly  Gly Thr Pro 
    2120                 2125                 2130             


Thr Leu  Ser Pro Pro Leu Cys  Ser Pro Asn Gly Tyr  Leu Gly Ser 
    2135                 2140                 2145             


Leu Lys  Pro Gly Val Gln Gly  Lys Lys Val Arg Lys  Pro Ser Ser 
    2150                 2155                 2160             


Lys Gly  Leu Ala Cys Gly Ser  Lys Glu Ala Lys Asp  Leu Lys Ala 
    2165                 2170                 2175             


Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly Cys Leu  Leu Asp Ser 
    2180                 2185                 2190             


Ser Gly  Met Leu Ser Pro Val  Asp Ser Leu Glu Ser  Pro His Gly 
    2195                 2200                 2205             


Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu Leu Pro  Ser Pro Phe 
    2210                 2215                 2220             


Gln Gln  Ser Pro Ser Val Pro  Leu Asn His Leu Pro  Gly Met Pro 
    2225                 2230                 2235             


Asp Thr  His Leu Gly Ile Gly  His Leu Asn Val Ala  Ala Lys Pro 
    2240                 2245                 2250             


Glu Met  Ala Ala Leu Gly Gly  Gly Gly Arg Leu Ala  Phe Glu Thr 
    2255                 2260                 2265             


Gly Pro  Pro Arg Leu Ser His  Leu Pro Val Ala Ser  Gly Thr Ser 
    2270                 2275                 2280             


Thr Val  Leu Gly Ser Ser Ser  Gly Gly Ala Leu Asn  Phe Thr Val 
    2285                 2290                 2295             


Gly Gly  Ser Thr Ser Leu Asn  Gly Gln Cys Glu Trp  Leu Ser Arg 
    2300                 2305                 2310             


Leu Gln  Ser Gly Met Val Pro  Asn Gln Tyr Asn Pro  Leu Arg Gly 
    2315                 2320                 2325             


Ser Val  Ala Pro Gly Pro Leu  Ser Thr Gln Ala Pro  Ser Leu Gln 
    2330                 2335                 2340             


His Gly  Met Val Gly Pro Leu  His Ser Ser Leu Ala  Ala Ser Ala 
    2345                 2350                 2355             


Leu Ser  Gln Met Met Ser Tyr  Gln Gly Leu Pro Ser  Thr Arg Leu 
    2360                 2365                 2370             


Ala Thr  Gln Pro His Leu Val  Gln Thr Gln Gln Val  Gln Pro Gln 
    2375                 2380                 2385             


Asn Leu  Gln Met Gln Gln Gln  Asn Leu Gln Pro Ala  Asn Ile Gln 
    2390                 2395                 2400             


Gln Gln  Gln Ser Leu Gln Pro  Pro Pro Pro Pro Pro  Gln Pro His 
    2405                 2410                 2415             


Leu Gly  Val Ser Ser Ala Ala  Ser Gly His Leu Gly  Arg Ser Phe 
    2420                 2425                 2430             


Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val Gln Pro  Leu Gly Pro 
    2435                 2440                 2445             


Ser Ser  Leu Ala Val His Thr  Ile Leu Pro Gln Glu  Ser Pro Ala 
    2450                 2455                 2460             


Leu Pro  Thr Ser Leu Pro Ser  Ser Leu Val Pro Pro  Val Thr Ala 
    2465                 2470                 2475             


Ala Gln  Phe Leu Thr Pro Pro  Ser Gln His Ser Tyr  Ser Ser Pro 
    2480                 2485                 2490             


Val Asp  Asn Thr Pro Ser His  Gln Leu Gln Val Pro  Glu His Pro 
    2495                 2500                 2505             


Phe Leu  Thr Pro Ser Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser 
    2510                 2515                 2520             


Ser Pro  His Ser Asn Val Ser  Asp Trp Ser Glu Gly  Val Ser Ser 
    2525                 2530                 2535             


Pro Pro  Thr Ser Met Gln Ser  Gln Ile Ala Arg Ile  Pro Glu Ala 
    2540                 2545                 2550             


Phe Lys  
    2555 


<210>  3
<211>  802
<212>  PRT
<213>  homo sapiens

<400>  3

Val Leu Leu Ser Arg Lys Arg Arg Arg Gln His Gly Gln Leu Trp Phe 
1               5                   10                  15      


Pro Glu Gly Phe Lys Val Ser Glu Ala Ser Lys Lys Lys Arg Arg Glu 
            20                  25                  30          


Pro Leu Gly Glu Asp Ser Val Gly Leu Lys Pro Leu Lys Asn Ala Ser 
        35                  40                  45              


Asp Gly Ala Leu Met Asp Asp Asn Gln Asn Glu Trp Gly Asp Glu Asp 
    50                  55                  60                  


Leu Glu Thr Lys Lys Phe Arg Phe Glu Glu Pro Val Val Leu Pro Asp 
65                  70                  75                  80  


Leu Asp Asp Gln Thr Asp His Arg Gln Trp Thr Gln Gln His Leu Asp 
                85                  90                  95      


Ala Ala Asp Leu Arg Met Ser Ala Met Ala Pro Thr Pro Pro Gln Gly 
            100                 105                 110         


Glu Val Asp Ala Asp Cys Met Asp Val Asn Val Arg Gly Pro Asp Gly 
        115                 120                 125             


Phe Thr Pro Leu Met Ile Ala Ser Cys Ser Gly Gly Gly Leu Glu Thr 
    130                 135                 140                 


Gly Asn Ser Glu Glu Glu Glu Asp Ala Pro Ala Val Ile Ser Asp Phe 
145                 150                 155                 160 


Ile Tyr Gln Gly Ala Ser Leu His Asn Gln Thr Asp Arg Thr Gly Glu 
                165                 170                 175     


Thr Ala Leu His Leu Ala Ala Arg Tyr Ser Arg Ser Asp Ala Ala Lys 
            180                 185                 190         


Arg Leu Leu Glu Ala Ser Ala Asp Ala Asn Ile Gln Asp Asn Met Gly 
        195                 200                 205             


Arg Thr Pro Leu His Ala Ala Val Ser Ala Asp Ala Gln Gly Val Phe 
    210                 215                 220                 


Gln Ile Leu Ile Arg Asn Arg Ala Thr Asp Leu Asp Ala Arg Met His 
225                 230                 235                 240 


Asp Gly Thr Thr Pro Leu Ile Leu Ala Ala Arg Leu Ala Val Glu Gly 
                245                 250                 255     


Met Leu Glu Asp Leu Ile Asn Ser His Ala Asp Val Asn Ala Val Asp 
            260                 265                 270         


Asp Leu Gly Lys Ser Ala Leu His Trp Ala Ala Ala Val Asn Asn Val 
        275                 280                 285             


Asp Ala Ala Val Val Leu Leu Lys Asn Gly Ala Asn Lys Asp Met Gln 
    290                 295                 300                 


Asn Asn Arg Glu Glu Thr Pro Leu Phe Leu Ala Ala Arg Glu Gly Ser 
305                 310                 315                 320 


Tyr Glu Thr Ala Lys Val Leu Leu Asp His Phe Ala Asn Arg Asp Ile 
                325                 330                 335     


Thr Asp His Met Asp Arg Leu Pro Arg Asp Ile Ala Gln Glu Arg Met 
            340                 345                 350         


His His Asp Ile Val Arg Leu Leu Asp Glu Tyr Asn Leu Val Arg Ser 
        355                 360                 365             


Pro Gln Leu His Gly Ala Pro Leu Gly Gly Thr Pro Thr Leu Ser Pro 
    370                 375                 380                 


Pro Leu Cys Ser Pro Asn Gly Tyr Leu Gly Ser Leu Lys Pro Gly Val 
385                 390                 395                 400 


Gln Gly Lys Lys Val Arg Lys Pro Ser Ser Lys Gly Leu Ala Cys Gly 
                405                 410                 415     


Ser Lys Glu Ala Lys Asp Leu Lys Ala Arg Arg Lys Lys Ser Gln Asp 
            420                 425                 430         


Gly Lys Gly Cys Leu Leu Asp Ser Ser Gly Met Leu Ser Pro Val Asp 
        435                 440                 445             


Ser Leu Glu Ser Pro His Gly Tyr Leu Ser Asp Val Ala Ser Pro Pro 
    450                 455                 460                 


Leu Leu Pro Ser Pro Phe Gln Gln Ser Pro Ser Val Pro Leu Asn His 
465                 470                 475                 480 


Leu Pro Gly Met Pro Asp Thr His Leu Gly Ile Gly His Leu Asn Val 
                485                 490                 495     


Ala Ala Lys Pro Glu Met Ala Ala Leu Gly Gly Gly Gly Arg Leu Ala 
            500                 505                 510         


Phe Glu Thr Gly Pro Pro Arg Leu Ser His Leu Pro Val Ala Ser Gly 
        515                 520                 525             


Thr Ser Thr Val Leu Gly Ser Ser Ser Gly Gly Ala Leu Asn Phe Thr 
    530                 535                 540                 


Val Gly Gly Ser Thr Ser Leu Asn Gly Gln Cys Glu Trp Leu Ser Arg 
545                 550                 555                 560 


Leu Gln Ser Gly Met Val Pro Asn Gln Tyr Asn Pro Leu Arg Gly Ser 
                565                 570                 575     


Val Ala Pro Gly Pro Leu Ser Thr Gln Ala Pro Ser Leu Gln His Gly 
            580                 585                 590         


Met Val Gly Pro Leu His Ser Ser Leu Ala Ala Ser Ala Leu Ser Gln 
        595                 600                 605             


Met Met Ser Tyr Gln Gly Leu Pro Ser Thr Arg Leu Ala Thr Gln Pro 
    610                 615                 620                 


His Leu Val Gln Thr Gln Gln Val Gln Pro Gln Asn Leu Gln Met Gln 
625                 630                 635                 640 


Gln Gln Asn Leu Gln Pro Ala Asn Ile Gln Gln Gln Gln Ser Leu Gln 
                645                 650                 655     


Pro Pro Pro Pro Pro Pro Gln Pro His Leu Gly Val Ser Ser Ala Ala 
            660                 665                 670         


Ser Gly His Leu Gly Arg Ser Phe Leu Ser Gly Glu Pro Ser Gln Ala 
        675                 680                 685             


Asp Val Gln Pro Leu Gly Pro Ser Ser Leu Ala Val His Thr Ile Leu 
    690                 695                 700                 


Pro Gln Glu Ser Pro Ala Leu Pro Thr Ser Leu Pro Ser Ser Leu Val 
705                 710                 715                 720 


Pro Pro Val Thr Ala Ala Gln Phe Leu Thr Pro Pro Ser Gln His Ser 
                725                 730                 735     


Tyr Ser Ser Pro Val Asp Asn Thr Pro Ser His Gln Leu Gln Val Pro 
            740                 745                 750         


Glu His Pro Phe Leu Thr Pro Ser Pro Glu Ser Pro Asp Gln Trp Ser 
        755                 760                 765             


Ser Ser Ser Pro His Ser Asn Val Ser Asp Trp Ser Glu Gly Val Ser 
    770                 775                 780                 


Ser Pro Pro Thr Ser Met Gln Ser Gln Ile Ala Arg Ile Pro Glu Ala 
785                 790                 795                 800 


Phe Lys 
        


