                         SEQUENCE LISTING

<110>  Max-Delbrck-Centrum fr Molekulare Medizin in der 
       Helmholtz-Gemeinschaft
 
<120>  A FRET-based method to measure seeding activity of misfolded 
       protein species in biological samples

<130>  66593P EP

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  3142
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln 
    50                  55                  60                  


Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Val 
65                  70                  75                  80  


Ala Glu Glu Pro Leu His Arg Pro Lys Lys Glu Leu Ser Ala Thr Lys 
                85                  90                  95      


Lys Asp Arg Val Asn His Cys Leu Thr Ile Cys Glu Asn Ile Val Ala 
            100                 105                 110         


Gln Ser Val Arg Asn Ser Pro Glu Phe Gln Lys Leu Leu Gly Ile Ala 
        115                 120                 125             


Met Glu Leu Phe Leu Leu Cys Ser Asp Asp Ala Glu Ser Asp Val Arg 
    130                 135                 140                 


Met Val Ala Asp Glu Cys Leu Asn Lys Val Ile Lys Ala Leu Met Asp 
145                 150                 155                 160 


Ser Asn Leu Pro Arg Leu Gln Leu Glu Leu Tyr Lys Glu Ile Lys Lys 
                165                 170                 175     


Asn Gly Ala Pro Arg Ser Leu Arg Ala Ala Leu Trp Arg Phe Ala Glu 
            180                 185                 190         


Leu Ala His Leu Val Arg Pro Gln Lys Cys Arg Pro Tyr Leu Val Asn 
        195                 200                 205             


Leu Leu Pro Cys Leu Thr Arg Thr Ser Lys Arg Pro Glu Glu Ser Val 
    210                 215                 220                 


Gln Glu Thr Leu Ala Ala Ala Val Pro Lys Ile Met Ala Ser Phe Gly 
225                 230                 235                 240 


Asn Phe Ala Asn Asp Asn Glu Ile Lys Val Leu Leu Lys Ala Phe Ile 
                245                 250                 255     


Ala Asn Leu Lys Ser Ser Ser Pro Thr Ile Arg Arg Thr Ala Ala Gly 
            260                 265                 270         


Ser Ala Val Ser Ile Cys Gln His Ser Arg Arg Thr Gln Tyr Phe Tyr 
        275                 280                 285             


Ser Trp Leu Leu Asn Val Leu Leu Gly Leu Leu Val Pro Val Glu Asp 
    290                 295                 300                 


Glu His Ser Thr Leu Leu Ile Leu Gly Val Leu Leu Thr Leu Arg Tyr 
305                 310                 315                 320 


Leu Val Pro Leu Leu Gln Gln Gln Val Lys Asp Thr Ser Leu Lys Gly 
                325                 330                 335     


Ser Phe Gly Val Thr Arg Lys Glu Met Glu Val Ser Pro Ser Ala Glu 
            340                 345                 350         


Gln Leu Val Gln Val Tyr Glu Leu Thr Leu His His Thr Gln His Gln 
        355                 360                 365             


Asp His Asn Val Val Thr Gly Ala Leu Glu Leu Leu Gln Gln Leu Phe 
    370                 375                 380                 


Arg Thr Pro Pro Pro Glu Leu Leu Gln Thr Leu Thr Ala Val Gly Gly 
385                 390                 395                 400 


Ile Gly Gln Leu Thr Ala Ala Lys Glu Glu Ser Gly Gly Arg Ser Arg 
                405                 410                 415     


Ser Gly Ser Ile Val Glu Leu Ile Ala Gly Gly Gly Ser Ser Cys Ser 
            420                 425                 430         


Pro Val Leu Ser Arg Lys Gln Lys Gly Lys Val Leu Leu Gly Glu Glu 
        435                 440                 445             


Glu Ala Leu Glu Asp Asp Ser Glu Ser Arg Ser Asp Val Ser Ser Ser 
    450                 455                 460                 


Ala Leu Thr Ala Ser Val Lys Asp Glu Ile Ser Gly Glu Leu Ala Ala 
465                 470                 475                 480 


Ser Ser Gly Val Ser Thr Pro Gly Ser Ala Gly His Asp Ile Ile Thr 
                485                 490                 495     


Glu Gln Pro Arg Ser Gln His Thr Leu Gln Ala Asp Ser Val Asp Leu 
            500                 505                 510         


Ala Ser Cys Asp Leu Thr Ser Ser Ala Thr Asp Gly Asp Glu Glu Asp 
        515                 520                 525             


Ile Leu Ser His Ser Ser Ser Gln Val Ser Ala Val Pro Ser Asp Pro 
    530                 535                 540                 


Ala Met Asp Leu Asn Asp Gly Thr Gln Ala Ser Ser Pro Ile Ser Asp 
545                 550                 555                 560 


Ser Ser Gln Thr Thr Thr Glu Gly Pro Asp Ser Ala Val Thr Pro Ser 
                565                 570                 575     


Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu Gly 
            580                 585                 590         


Leu Gln Ile Gly Gln Pro Gln Asp Glu Asp Glu Glu Ala Thr Gly Ile 
        595                 600                 605             


Leu Pro Asp Glu Ala Ser Glu Ala Phe Arg Asn Ser Ser Met Ala Leu 
    610                 615                 620                 


Gln Gln Ala His Leu Leu Lys Asn Met Ser His Cys Arg Gln Pro Ser 
625                 630                 635                 640 


Asp Ser Ser Val Asp Lys Phe Val Leu Arg Asp Glu Ala Thr Glu Pro 
                645                 650                 655     


Gly Asp Gln Glu Asn Lys Pro Cys Arg Ile Lys Gly Asp Ile Gly Gln 
            660                 665                 670         


Ser Thr Asp Asp Asp Ser Ala Pro Leu Val His Cys Val Arg Leu Leu 
        675                 680                 685             


Ser Ala Ser Phe Leu Leu Thr Gly Gly Lys Asn Val Leu Val Pro Asp 
    690                 695                 700                 


Arg Asp Val Arg Val Ser Val Lys Ala Leu Ala Leu Ser Cys Val Gly 
705                 710                 715                 720 


Ala Ala Val Ala Leu His Pro Glu Ser Phe Phe Ser Lys Leu Tyr Lys 
                725                 730                 735     


Val Pro Leu Asp Thr Thr Glu Tyr Pro Glu Glu Gln Tyr Val Ser Asp 
            740                 745                 750         


Ile Leu Asn Tyr Ile Asp His Gly Asp Pro Gln Val Arg Gly Ala Thr 
        755                 760                 765             


Ala Ile Leu Cys Gly Thr Leu Ile Cys Ser Ile Leu Ser Arg Ser Arg 
    770                 775                 780                 


Phe His Val Gly Asp Trp Met Gly Thr Ile Arg Thr Leu Thr Gly Asn 
785                 790                 795                 800 


Thr Phe Ser Leu Ala Asp Cys Ile Pro Leu Leu Arg Lys Thr Leu Lys 
                805                 810                 815     


Asp Glu Ser Ser Val Thr Cys Lys Leu Ala Cys Thr Ala Val Arg Asn 
            820                 825                 830         


Cys Val Met Ser Leu Cys Ser Ser Ser Tyr Ser Glu Leu Gly Leu Gln 
        835                 840                 845             


Leu Ile Ile Asp Val Leu Thr Leu Arg Asn Ser Ser Tyr Trp Leu Val 
    850                 855                 860                 


Arg Thr Glu Leu Leu Glu Thr Leu Ala Glu Ile Asp Phe Arg Leu Val 
865                 870                 875                 880 


Ser Phe Leu Glu Ala Lys Ala Glu Asn Leu His Arg Gly Ala His His 
                885                 890                 895     


Tyr Thr Gly Leu Leu Lys Leu Gln Glu Arg Val Leu Asn Asn Val Val 
            900                 905                 910         


Ile His Leu Leu Gly Asp Glu Asp Pro Arg Val Arg His Val Ala Ala 
        915                 920                 925             


Ala Ser Leu Ile Arg Leu Val Pro Lys Leu Phe Tyr Lys Cys Asp Gln 
    930                 935                 940                 


Gly Gln Ala Asp Pro Val Val Ala Val Ala Arg Asp Gln Ser Ser Val 
945                 950                 955                 960 


Tyr Leu Lys Leu Leu Met His Glu Thr Gln Pro Pro Ser His Phe Ser 
                965                 970                 975     


Val Ser Thr Ile Thr Arg Ile Tyr Arg Gly Tyr Asn Leu Leu Pro Ser 
            980                 985                 990         


Ile Thr Asp Val Thr Met Glu Asn  Asn Leu Ser Arg Val  Ile Ala Ala 
        995                 1000                 1005             


Val Ser  His Glu Leu Ile Thr  Ser Thr Thr Arg Ala  Leu Thr Phe 
    1010                 1015                 1020             


Gly Cys  Cys Glu Ala Leu Cys  Leu Leu Ser Thr Ala  Phe Pro Val 
    1025                 1030                 1035             


Cys Ile  Trp Ser Leu Gly Trp  His Cys Gly Val Pro  Pro Leu Ser 
    1040                 1045                 1050             


Ala Ser  Asp Glu Ser Arg Lys  Ser Cys Thr Val Gly  Met Ala Thr 
    1055                 1060                 1065             


Met Ile  Leu Thr Leu Leu Ser  Ser Ala Trp Phe Pro  Leu Asp Leu 
    1070                 1075                 1080             


Ser Ala  His Gln Asp Ala Leu  Ile Leu Ala Gly Asn  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ser  Ala Pro Lys Ser Leu  Arg Ser Ser Trp Ala  Ser Glu Glu 
    1100                 1105                 1110             


Glu Ala  Asn Pro Ala Ala Thr  Lys Gln Glu Glu Val  Trp Pro Ala 
    1115                 1120                 1125             


Leu Gly  Asp Arg Ala Leu Val  Pro Met Val Glu Gln  Leu Phe Ser 
    1130                 1135                 1140             


His Leu  Leu Lys Val Ile Asn  Ile Cys Ala His Val  Leu Asp Asp 
    1145                 1150                 1155             


Val Ala  Pro Gly Pro Ala Ile  Lys Ala Ala Leu Pro  Ser Leu Thr 
    1160                 1165                 1170             


Asn Pro  Pro Ser Leu Ser Pro  Ile Arg Arg Lys Gly  Lys Glu Lys 
    1175                 1180                 1185             


Glu Pro  Gly Glu Gln Ala Ser  Val Pro Leu Ser Pro  Lys Lys Gly 
    1190                 1195                 1200             


Ser Glu  Ala Ser Ala Ala Ser  Arg Gln Ser Asp Thr  Ser Gly Pro 
    1205                 1210                 1215             


Val Thr  Thr Ser Lys Ser Ser  Ser Leu Gly Ser Phe  Tyr His Leu 
    1220                 1225                 1230             


Pro Ser  Tyr Leu Lys Leu His  Asp Val Leu Lys Ala  Thr His Ala 
    1235                 1240                 1245             


Asn Tyr  Lys Val Thr Leu Asp  Leu Gln Asn Ser Thr  Glu Lys Phe 
    1250                 1255                 1260             


Gly Gly  Phe Leu Arg Ser Ala  Leu Asp Val Leu Ser  Gln Ile Leu 
    1265                 1270                 1275             


Glu Leu  Ala Thr Leu Gln Asp  Ile Gly Lys Cys Val  Glu Glu Ile 
    1280                 1285                 1290             


Leu Gly  Tyr Leu Lys Ser Cys  Phe Ser Arg Glu Pro  Met Met Ala 
    1295                 1300                 1305             


Thr Val  Cys Val Gln Gln Leu  Leu Lys Thr Leu Phe  Gly Thr Asn 
    1310                 1315                 1320             


Leu Ala  Ser Gln Phe Asp Gly  Leu Ser Ser Asn Pro  Ser Lys Ser 
    1325                 1330                 1335             


Gln Gly  Arg Ala Gln Arg Leu  Gly Ser Ser Ser Val  Arg Pro Gly 
    1340                 1345                 1350             


Leu Tyr  His Tyr Cys Phe Met  Ala Pro Tyr Thr His  Phe Thr Gln 
    1355                 1360                 1365             


Ala Leu  Ala Asp Ala Ser Leu  Arg Asn Met Val Gln  Ala Glu Gln 
    1370                 1375                 1380             


Glu Asn  Asp Thr Ser Gly Trp  Phe Asp Val Leu Gln  Lys Val Ser 
    1385                 1390                 1395             


Thr Gln  Leu Lys Thr Asn Leu  Thr Ser Val Thr Lys  Asn Arg Ala 
    1400                 1405                 1410             


Asp Lys  Asn Ala Ile His Asn  His Ile Arg Leu Phe  Glu Pro Leu 
    1415                 1420                 1425             


Val Ile  Lys Ala Leu Lys Gln  Tyr Thr Thr Thr Thr  Cys Val Gln 
    1430                 1435                 1440             


Leu Gln  Lys Gln Val Leu Asp  Leu Leu Ala Gln Leu  Val Gln Leu 
    1445                 1450                 1455             


Arg Val  Asn Tyr Cys Leu Leu  Asp Ser Asp Gln Val  Phe Ile Gly 
    1460                 1465                 1470             


Phe Val  Leu Lys Gln Phe Glu  Tyr Ile Glu Val Gly  Gln Phe Arg 
    1475                 1480                 1485             


Glu Ser  Glu Ala Ile Ile Pro  Asn Ile Phe Phe Phe  Leu Val Leu 
    1490                 1495                 1500             


Leu Ser  Tyr Glu Arg Tyr His  Ser Lys Gln Ile Ile  Gly Ile Pro 
    1505                 1510                 1515             


Lys Ile  Ile Gln Leu Cys Asp  Gly Ile Met Ala Ser  Gly Arg Lys 
    1520                 1525                 1530             


Ala Val  Thr His Ala Ile Pro  Ala Leu Gln Pro Ile  Val His Asp 
    1535                 1540                 1545             


Leu Phe  Val Leu Arg Gly Thr  Asn Lys Ala Asp Ala  Gly Lys Glu 
    1550                 1555                 1560             


Leu Glu  Thr Gln Lys Glu Val  Val Val Ser Met Leu  Leu Arg Leu 
    1565                 1570                 1575             


Ile Gln  Tyr His Gln Val Leu  Glu Met Phe Ile Leu  Val Leu Gln 
    1580                 1585                 1590             


Gln Cys  His Lys Glu Asn Glu  Asp Lys Trp Lys Arg  Leu Ser Arg 
    1595                 1600                 1605             


Gln Ile  Ala Asp Ile Ile Leu  Pro Met Leu Ala Lys  Gln Gln Met 
    1610                 1615                 1620             


His Ile  Asp Ser His Glu Ala  Leu Gly Val Leu Asn  Thr Leu Phe 
    1625                 1630                 1635             


Glu Ile  Leu Ala Pro Ser Ser  Leu Arg Pro Val Asp  Met Leu Leu 
    1640                 1645                 1650             


Arg Ser  Met Phe Val Thr Pro  Asn Thr Met Ala Ser  Val Ser Thr 
    1655                 1660                 1665             


Val Gln  Leu Trp Ile Ser Gly  Ile Leu Ala Ile Leu  Arg Val Leu 
    1670                 1675                 1680             


Ile Ser  Gln Ser Thr Glu Asp  Ile Val Leu Ser Arg  Ile Gln Glu 
    1685                 1690                 1695             


Leu Ser  Phe Ser Pro Tyr Leu  Ile Ser Cys Thr Val  Ile Asn Arg 
    1700                 1705                 1710             


Leu Arg  Asp Gly Asp Ser Thr  Ser Thr Leu Glu Glu  His Ser Glu 
    1715                 1720                 1725             


Gly Lys  Gln Ile Lys Asn Leu  Pro Glu Glu Thr Phe  Ser Arg Phe 
    1730                 1735                 1740             


Leu Leu  Gln Leu Val Gly Ile  Leu Leu Glu Asp Ile  Val Thr Lys 
    1745                 1750                 1755             


Gln Leu  Lys Val Glu Met Ser  Glu Gln Gln His Thr  Phe Tyr Cys 
    1760                 1765                 1770             


Gln Glu  Leu Gly Thr Leu Leu  Met Cys Leu Ile His  Ile Phe Lys 
    1775                 1780                 1785             


Ser Gly  Met Phe Arg Arg Ile  Thr Ala Ala Ala Thr  Arg Leu Phe 
    1790                 1795                 1800             


Arg Ser  Asp Gly Cys Gly Gly  Ser Phe Tyr Thr Leu  Asp Ser Leu 
    1805                 1810                 1815             


Asn Leu  Arg Ala Arg Ser Met  Ile Thr Thr His Pro  Ala Leu Val 
    1820                 1825                 1830             


Leu Leu  Trp Cys Gln Ile Leu  Leu Leu Val Asn His  Thr Asp Tyr 
    1835                 1840                 1845             


Arg Trp  Trp Ala Glu Val Gln  Gln Thr Pro Lys Arg  His Ser Leu 
    1850                 1855                 1860             


Ser Ser  Thr Lys Leu Leu Ser  Pro Gln Met Ser Gly  Glu Glu Glu 
    1865                 1870                 1875             


Asp Ser  Asp Leu Ala Ala Lys  Leu Gly Met Cys Asn  Arg Glu Ile 
    1880                 1885                 1890             


Val Arg  Arg Gly Ala Leu Ile  Leu Phe Cys Asp Tyr  Val Cys Gln 
    1895                 1900                 1905             


Asn Leu  His Asp Ser Glu His  Leu Thr Trp Leu Ile  Val Asn His 
    1910                 1915                 1920             


Ile Gln  Asp Leu Ile Ser Leu  Ser His Glu Pro Pro  Val Gln Asp 
    1925                 1930                 1935             


Phe Ile  Ser Ala Val His Arg  Asn Ser Ala Ala Ser  Gly Leu Phe 
    1940                 1945                 1950             


Ile Gln  Ala Ile Gln Ser Arg  Cys Glu Asn Leu Ser  Thr Pro Thr 
    1955                 1960                 1965             


Met Leu  Lys Lys Thr Leu Gln  Cys Leu Glu Gly Ile  His Leu Ser 
    1970                 1975                 1980             


Gln Ser  Gly Ala Val Leu Thr  Leu Tyr Val Asp Arg  Leu Leu Cys 
    1985                 1990                 1995             


Thr Pro  Phe Arg Val Leu Ala  Arg Met Val Asp Ile  Leu Ala Cys 
    2000                 2005                 2010             


Arg Arg  Val Glu Met Leu Leu  Ala Ala Asn Leu Gln  Ser Ser Met 
    2015                 2020                 2025             


Ala Gln  Leu Pro Met Glu Glu  Leu Asn Arg Ile Gln  Glu Tyr Leu 
    2030                 2035                 2040             


Gln Ser  Ser Gly Leu Ala Gln  Arg His Gln Arg Leu  Tyr Ser Leu 
    2045                 2050                 2055             


Leu Asp  Arg Phe Arg Leu Ser  Thr Met Gln Asp Ser  Leu Ser Pro 
    2060                 2065                 2070             


Ser Pro  Pro Val Ser Ser His  Pro Leu Asp Gly Asp  Gly His Val 
    2075                 2080                 2085             


Ser Leu  Glu Thr Val Ser Pro  Asp Lys Asp Trp Tyr  Val His Leu 
    2090                 2095                 2100             


Val Lys  Ser Gln Cys Trp Thr  Arg Ser Asp Ser Ala  Leu Leu Glu 
    2105                 2110                 2115             


Gly Ala  Glu Leu Val Asn Arg  Ile Pro Ala Glu Asp  Met Asn Ala 
    2120                 2125                 2130             


Phe Met  Met Asn Ser Glu Phe  Asn Leu Ser Leu Leu  Ala Pro Cys 
    2135                 2140                 2145             


Leu Ser  Leu Gly Met Ser Glu  Ile Ser Gly Gly Gln  Lys Ser Ala 
    2150                 2155                 2160             


Leu Phe  Glu Ala Ala Arg Glu  Val Thr Leu Ala Arg  Val Ser Gly 
    2165                 2170                 2175             


Thr Val  Gln Gln Leu Pro Ala  Val His His Val Phe  Gln Pro Glu 
    2180                 2185                 2190             


Leu Pro  Ala Glu Pro Ala Ala  Tyr Trp Ser Lys Leu  Asn Asp Leu 
    2195                 2200                 2205             


Phe Gly  Asp Ala Ala Leu Tyr  Gln Ser Leu Pro Thr  Leu Ala Arg 
    2210                 2215                 2220             


Ala Leu  Ala Gln Tyr Leu Val  Val Val Ser Lys Leu  Pro Ser His 
    2225                 2230                 2235             


Leu His  Leu Pro Pro Glu Lys  Glu Lys Asp Ile Val  Lys Phe Val 
    2240                 2245                 2250             


Val Ala  Thr Leu Glu Ala Leu  Ser Trp His Leu Ile  His Glu Gln 
    2255                 2260                 2265             


Ile Pro  Leu Ser Leu Asp Leu  Gln Ala Gly Leu Asp  Cys Cys Cys 
    2270                 2275                 2280             


Leu Ala  Leu Gln Leu Pro Gly  Leu Trp Ser Val Val  Ser Ser Thr 
    2285                 2290                 2295             


Glu Phe  Val Thr His Ala Cys  Ser Leu Ile Tyr Cys  Val His Phe 
    2300                 2305                 2310             


Ile Leu  Glu Ala Val Ala Val  Gln Pro Gly Glu Gln  Leu Leu Ser 
    2315                 2320                 2325             


Pro Glu  Arg Arg Thr Asn Thr  Pro Lys Ala Ile Ser  Glu Glu Glu 
    2330                 2335                 2340             


Glu Glu  Val Asp Pro Asn Thr  Gln Asn Pro Lys Tyr  Ile Thr Ala 
    2345                 2350                 2355             


Ala Cys  Glu Met Val Ala Glu  Met Val Glu Ser Leu  Gln Ser Val 
    2360                 2365                 2370             


Leu Ala  Leu Gly His Lys Arg  Asn Ser Gly Val Pro  Ala Phe Leu 
    2375                 2380                 2385             


Thr Pro  Leu Leu Arg Asn Ile  Ile Ile Ser Leu Ala  Arg Leu Pro 
    2390                 2395                 2400             


Leu Val  Asn Ser Tyr Thr Arg  Val Pro Pro Leu Val  Trp Lys Leu 
    2405                 2410                 2415             


Gly Trp  Ser Pro Lys Pro Gly  Gly Asp Phe Gly Thr  Ala Phe Pro 
    2420                 2425                 2430             


Glu Ile  Pro Val Glu Phe Leu  Gln Glu Lys Glu Val  Phe Lys Glu 
    2435                 2440                 2445             


Phe Ile  Tyr Arg Ile Asn Thr  Leu Gly Trp Thr Ser  Arg Thr Gln 
    2450                 2455                 2460             


Phe Glu  Glu Thr Trp Ala Thr  Leu Leu Gly Val Leu  Val Thr Gln 
    2465                 2470                 2475             


Pro Leu  Val Met Glu Gln Glu  Glu Ser Pro Pro Glu  Glu Asp Thr 
    2480                 2485                 2490             


Glu Arg  Thr Gln Ile Asn Val  Leu Ala Val Gln Ala  Ile Thr Ser 
    2495                 2500                 2505             


Leu Val  Leu Ser Ala Met Thr  Val Pro Val Ala Gly  Asn Pro Ala 
    2510                 2515                 2520             


Val Ser  Cys Leu Glu Gln Gln  Pro Arg Asn Lys Pro  Leu Lys Ala 
    2525                 2530                 2535             


Leu Asp  Thr Arg Phe Gly Arg  Lys Leu Ser Ile Ile  Arg Gly Ile 
    2540                 2545                 2550             


Val Glu  Gln Glu Ile Gln Ala  Met Val Ser Lys Arg  Glu Asn Ile 
    2555                 2560                 2565             


Ala Thr  His His Leu Tyr Gln  Ala Trp Asp Pro Val  Pro Ser Leu 
    2570                 2575                 2580             


Ser Pro  Ala Thr Thr Gly Ala  Leu Ile Ser His Glu  Lys Leu Leu 
    2585                 2590                 2595             


Leu Gln  Ile Asn Pro Glu Arg  Glu Leu Gly Ser Met  Ser Tyr Lys 
    2600                 2605                 2610             


Leu Gly  Gln Val Ser Ile His  Ser Val Trp Leu Gly  Asn Ser Ile 
    2615                 2620                 2625             


Thr Pro  Leu Arg Glu Glu Glu  Trp Asp Glu Glu Glu  Glu Glu Glu 
    2630                 2635                 2640             


Ala Asp  Ala Pro Ala Pro Ser  Ser Pro Pro Thr Ser  Pro Val Asn 
    2645                 2650                 2655             


Ser Arg  Lys His Arg Ala Gly  Val Asp Ile His Ser  Cys Ser Gln 
    2660                 2665                 2670             


Phe Leu  Leu Glu Leu Tyr Ser  Arg Trp Ile Leu Pro  Ser Ser Ser 
    2675                 2680                 2685             


Ala Arg  Arg Thr Pro Ala Ile  Leu Ile Ser Glu Val  Val Arg Ser 
    2690                 2695                 2700             


Leu Leu  Val Val Ser Asp Leu  Phe Thr Glu Arg Asn  Gln Phe Glu 
    2705                 2710                 2715             


Leu Met  Tyr Val Thr Leu Thr  Glu Leu Arg Arg Val  His Pro Ser 
    2720                 2725                 2730             


Glu Asp  Glu Ile Leu Ala Gln  Tyr Leu Val Pro Ala  Thr Cys Lys 
    2735                 2740                 2745             


Ala Ala  Ala Val Leu Gly Met  Asp Lys Ala Val Ala  Glu Pro Val 
    2750                 2755                 2760             


Ser Arg  Leu Leu Glu Ser Thr  Leu Arg Ser Ser His  Leu Pro Ser 
    2765                 2770                 2775             


Arg Val  Gly Ala Leu His Gly  Val Leu Tyr Val Leu  Glu Cys Asp 
    2780                 2785                 2790             


Leu Leu  Asp Asp Thr Ala Lys  Gln Leu Ile Pro Val  Ile Ser Asp 
    2795                 2800                 2805             


Tyr Leu  Leu Ser Asn Leu Lys  Gly Ile Ala His Cys  Val Asn Ile 
    2810                 2815                 2820             


His Ser  Gln Gln His Val Leu  Val Met Cys Ala Thr  Ala Phe Tyr 
    2825                 2830                 2835             


Leu Ile  Glu Asn Tyr Pro Leu  Asp Val Gly Pro Glu  Phe Ser Ala 
    2840                 2845                 2850             


Ser Ile  Ile Gln Met Cys Gly  Val Met Leu Ser Gly  Ser Glu Glu 
    2855                 2860                 2865             


Ser Thr  Pro Ser Ile Ile Tyr  His Cys Ala Leu Arg  Gly Leu Glu 
    2870                 2875                 2880             


Arg Leu  Leu Leu Ser Glu Gln  Leu Ser Arg Leu Asp  Ala Glu Ser 
    2885                 2890                 2895             


Leu Val  Lys Leu Ser Val Asp  Arg Val Asn Val His  Ser Pro His 
    2900                 2905                 2910             


Arg Ala  Met Ala Ala Leu Gly  Leu Met Leu Thr Cys  Met Tyr Thr 
    2915                 2920                 2925             


Gly Lys  Glu Lys Val Ser Pro  Gly Arg Thr Ser Asp  Pro Asn Pro 
    2930                 2935                 2940             


Ala Ala  Pro Asp Ser Glu Ser  Val Ile Val Ala Met  Glu Arg Val 
    2945                 2950                 2955             


Ser Val  Leu Phe Asp Arg Ile  Arg Lys Gly Phe Pro  Cys Glu Ala 
    2960                 2965                 2970             


Arg Val  Val Ala Arg Ile Leu  Pro Gln Phe Leu Asp  Asp Phe Phe 
    2975                 2980                 2985             


Pro Pro  Gln Asp Ile Met Asn  Lys Val Ile Gly Glu  Phe Leu Ser 
    2990                 2995                 3000             


Asn Gln  Gln Pro Tyr Pro Gln  Phe Met Ala Thr Val  Val Tyr Lys 
    3005                 3010                 3015             


Val Phe  Gln Thr Leu His Ser  Thr Gly Gln Ser Ser  Met Val Arg 
    3020                 3025                 3030             


Asp Trp  Val Met Leu Ser Leu  Ser Asn Phe Thr Gln  Arg Ala Pro 
    3035                 3040                 3045             


Val Ala  Met Ala Thr Trp Ser  Leu Ser Cys Phe Phe  Val Ser Ala 
    3050                 3055                 3060             


Ser Thr  Ser Pro Trp Val Ala  Ala Ile Leu Pro His  Val Ile Ser 
    3065                 3070                 3075             


Arg Met  Gly Lys Leu Glu Gln  Val Asp Val Asn Leu  Phe Cys Leu 
    3080                 3085                 3090             


Val Ala  Thr Asp Phe Tyr Arg  His Gln Ile Glu Glu  Glu Leu Asp 
    3095                 3100                 3105             


Arg Arg  Ala Phe Gln Ser Val  Leu Glu Val Val Ala  Ala Pro Gly 
    3110                 3115                 3120             


Ser Pro  Tyr His Arg Leu Leu  Thr Cys Leu Arg Asn  Val His Lys 
    3125                 3130                 3135             


Val Thr  Thr Cys 
    3140         


<210>  2
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln 
65                  70                  75                  80  


Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Leu Gln Pro Pro Pro 
                85                  90                  95      


Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Ala Ala Glu Glu Pro Leu 
            100                 105                 110         


His Arg Pro 
        115 


<210>  3
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcgaccc tggaaaagct gatgaaggcc ttcgagtccc tcaagtcctt ccagcagcag       60

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      120

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      180

cagcagcagc aacagccgcc accgccgccg ccgccgccgc cgcctcctca gcttcctcag      240

ccgccgccgc aggcacagcc gctgctgcct cagctgcagc cgcccccgcc gccgcccccg      300

ccgccacccg gcccggccgc ggctgaggag ccgctgcacc gacca                      345


<210>  4
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro 
65                  70                  75                  80  


Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Leu Gln Pro Pro 
                85                  90                  95      


Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Ala Ala Glu Glu Pro 
            100                 105                 110         


Leu His Arg Pro 
        115     


<210>  5
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  5
atggcgaccc tggaaaagct gatgaaggcc ttcgagtccc tcaagtcctt ccagcagcag       60

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      120

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      180

cagcagcagc agcaacagcc gccaccgccg ccgccgccgc cgccgcctcc tcagcttcct      240

cagccgccgc cgcaggcaca gccgctgctg cctcagctgc agccgccccc gccgccgccc      300

ccgccgccac ccggcccggc cgcggctgag gagccgctgc accgacca                   348


<210>  6
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cloned glutathione-S-transferase

<400>  6

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys 
    210                 215             


<210>  7
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cloned glutathione-S-transferase

<400>  7
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaa            654


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease recognition sequence

<400>  8

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  9
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mHTT GST-Ex1Q48

<400>  9

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Pro Glu Phe Met Ala Thr Leu Glu Lys 
225                 230                 235                 240 


Leu Met Lys Ala Phe Glu Ser Leu Lys Ser Phe Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        275                 280                 285             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro 
    290                 295                 300                 


Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln 
305                 310                 315                 320 


Pro Leu Leu Pro Gln Leu Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro 
                325                 330                 335     


Pro Gly Pro Ala Ala Ala Glu Glu Pro Leu His Arg Pro 
            340                 345                 


<210>  10
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mHTT GST-Ex1Q48

<400>  10
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tccccggaat tcatggcgac cctggaaaag      720

ctgatgaagg ccttcgagtc cctcaagtcc ttccagcagc agcagcagca gcagcagcag      780

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      840

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcaacagccg      900

ccaccgccgc cgccgccgcc gccgcctcct cagcttcctc agccgccgcc gcaggcacag      960

ccgctgctgc ctcagctgca gccgcccccg ccgccgcccc cgccgccacc cggcccggcc     1020

gcggctgagg agccgctgca ccgacca                                         1047


<210>  11
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mHTT GST-Ex1Q49

<400>  11

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Pro Glu Phe Met Ala Thr Leu Glu Lys 
225                 230                 235                 240 


Leu Met Lys Ala Phe Glu Ser Leu Lys Ser Phe Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        275                 280                 285             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro 
    290                 295                 300                 


Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala 
305                 310                 315                 320 


Gln Pro Leu Leu Pro Gln Leu Gln Pro Pro Pro Pro Pro Pro Pro Pro 
                325                 330                 335     


Pro Pro Gly Pro Ala Ala Ala Glu Glu Pro Leu His Arg Pro 
            340                 345                 350 


<210>  12
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mHTT GST-Ex1Q49

<400>  12
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tccccggaat tcatggcgac cctggaaaag      720

ctgatgaagg ccttcgagtc cctcaagtcc ttccagcagc agcagcagca gcagcagcag      780

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      840

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcaacag      900

ccgccaccgc cgccgccgcc gccgccgcct cctcagcttc ctcagccgcc gccgcaggca      960

cagccgctgc tgcctcagct gcagccgccc ccgccgccgc ccccgccgcc acccggcccg     1020

gccgcggctg aggagccgct gcaccgacca                                      1050


<210>  13
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mHTT Ex1Q48-YPet

<400>  13

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln 
65                  70                  75                  80  


Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Leu Gln Pro Pro Pro 
                85                  90                  95      


Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Ala Ala Glu Glu Pro Leu 
            100                 105                 110         


His Arg Pro Leu Glu Gly Gly Gly Gly Gly Met Ser Lys Gly Glu Glu 
        115                 120                 125             


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
    130                 135                 140                 


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
145                 150                 155                 160 


Tyr Gly Lys Leu Thr Leu Lys Leu Leu Cys Thr Thr Gly Lys Leu Pro 
                165                 170                 175     


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Val Gln Cys 
            180                 185                 190         


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
        195                 200                 205             


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
    210                 215                 220                 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
225                 230                 235                 240 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                245                 250                 255     


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
            260                 265                 270         


Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys 
        275                 280                 285             


Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr 
    290                 295                 300                 


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
305                 310                 315                 320 


His Tyr Leu Ser Tyr Gln Ser Ala Leu Phe Lys Asp Pro Asn Glu Lys 
                325                 330                 335     


Arg Asp His Met Val Leu Leu Glu Phe Leu Thr Ala Ala Gly Ile Thr 
            340                 345                 350         


Glu Gly Met Asn Glu Leu Tyr Lys 
        355                 360 


<210>  14
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mHTT Ex1Q48-YPet

<400>  14
atggcgaccc tggaaaagct gatgaaggcc ttcgagtccc tcaagtcctt ccagcagcag       60

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      120

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      180

cagcagcagc aacagccgcc accgccgccg ccgccgccgc cgcctcctca gcttcctcag      240

ccgccgccgc aggcacagcc gctgctgcct cagctgcagc cgcccccgcc gccgcccccg      300

ccgccacccg gcccggccgc ggctgaggag ccgctgcacc gaccactcga gggtggcggt      360

ggcggtatgt ctaaaggtga agaattattc actggtgttg tcccaatttt ggttgaatta      420

gatggtgatg ttaatggtca caaattttct gtctccggtg aaggtgaagg tgatgctacg      480

tacggtaaat tgaccttaaa attactctgt actactggta aattgccagt tccatggcca      540

accttagtca ctactttagg ttatggtgtt caatgttttg ctagataccc agatcatatg      600

aaacaacatg actttttcaa gtctgccatg ccagaaggtt atgttcaaga aagaactatt      660

tttttcaaag atgacggtaa ctacaagacc agagctgaag tcaagtttga aggtgatacc      720

ttagttaata gaatcgaatt aaaaggtatt gattttaaag aagatggtaa cattttaggt      780

cacaaattgg aatacaacta taactctcac aatgtttaca tcactgctga caaacaaaag      840

aatggtatca aagctaactt caaaattaga cacaacattg aagatggtgg tgttcaatta      900

gctgaccatt atcaacaaaa tactccaatt ggtgatggtc cagtcttgtt accagacaac      960

cattacttat cctatcaatc tgccttattc aaagatccaa acgaaaagag agaccacatg     1020

gtcttgttag aatttttgac tgctgctggt attaccgagg gtatgaatga attgtacaaa     1080


<210>  15
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mHTT Ex1Q48-CyPet

<400>  15

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln 
65                  70                  75                  80  


Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Leu Gln Pro Pro Pro 
                85                  90                  95      


Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Ala Ala Glu Glu Pro Leu 
            100                 105                 110         


His Arg Pro Leu Glu Gly Gly Gly Gly Gly Met Ser Lys Gly Glu Glu 
        115                 120                 125             


Leu Phe Gly Gly Ile Val Pro Ile Leu Val Glu Leu Glu Gly Asp Val 
    130                 135                 140                 


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
145                 150                 155                 160 


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
                165                 170                 175     


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Trp Gly Val Gln Cys 
            180                 185                 190         


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
        195                 200                 205             


Val Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
    210                 215                 220                 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
225                 230                 235                 240 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                245                 250                 255     


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Ile Ser His Asn Val 
            260                 265                 270         


Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys 
        275                 280                 285             


Ala Arg His Asn Ile Thr Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
    290                 295                 300                 


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Ile Leu Pro Asp Asn 
305                 310                 315                 320 


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
                325                 330                 335     


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
            340                 345                 350         


His Gly Met Asp Glu Leu Tyr Lys 
        355                 360 


<210>  16
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mHTT Ex1Q48-CyPet

<400>  16
atggcgaccc tggaaaagct gatgaaggcc ttcgagtccc tcaagtcctt ccagcagcag       60

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      120

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      180

cagcagcagc aacagccgcc accgccgccg cccccgccgc cgcctcctca gcttcctcag      240

ccgccgccgc aggcacagcc gctgctgcct cagctgcagc cgcccccgcc gccgcccccg      300

ccgccacccg gcccggccgc ggctgaggag ccgctgcacc gaccactcga gggtggcggt      360

ggcggtatgt ctaaaggtga agaattattc ggcggtatcg tcccaatttt agttgaatta      420

gagggtgatg ttaatggtca caaattttct gtctccggtg aaggtgaagg tgatgctacg      480

tacggtaaat tgaccttaaa atttatttgt actactggta aattgccagt tccatggcca      540

accttagtca ctactctgac ttggggtgtt caatgttttt ctagataccc agatcatatg      600

aaacaacatg actttttcaa gtctgtcatg ccagaaggtt atgttcaaga aagaactatt      660

tttttcaaag atgacggtaa ctacaagacc agagctgaag tcaagtttga aggtgatacc      720

ttagttaata gaatcgaatt aaaaggtatt gattttaaag aagatggtaa cattttaggt      780

cacaaattgg aatacaacta tatctctcac aatgtttaca tcaccgctga caaacaaaag      840

aatggtatca aagctaactt caaagccaga cacaacatta ccgatggttc tgttcaatta      900

gctgaccatt atcaacaaaa tactccaatt ggtgatggtc cagtcatctt gccagacaac      960

cattacttat ccactcaatc tgccttatct aaagatccaa acgaaaagag agaccacatg     1020

gtcttgctcg aatttgttac tgctgctggt attacccatg gtatggatga attgtacaaa     1080


<210>  17
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mHTT GST-Ex1Q48-YPet

<400>  17

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Pro Glu Phe Met Ala Thr Leu Glu Lys 
225                 230                 235                 240 


Leu Met Lys Ala Phe Glu Ser Leu Lys Ser Phe Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        275                 280                 285             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro 
    290                 295                 300                 


Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln 
305                 310                 315                 320 


Pro Leu Leu Pro Gln Leu Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro 
                325                 330                 335     


Pro Gly Pro Ala Ala Ala Glu Glu Pro Leu His Arg Pro Leu Glu Gly 
            340                 345                 350         


Gly Gly Gly Gly Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
        355                 360                 365             


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
    370                 375                 380                 


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
385                 390                 395                 400 


Lys Leu Leu Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
                405                 410                 415     


Val Thr Thr Leu Gly Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp 
            420                 425                 430         


His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
        435                 440                 445             


Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
    450                 455                 460                 


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
465                 470                 475                 480 


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
                485                 490                 495     


Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys 
            500                 505                 510         


Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu 
        515                 520                 525             


Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
    530                 535                 540                 


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln 
545                 550                 555                 560 


Ser Ala Leu Phe Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
                565                 570                 575     


Leu Glu Phe Leu Thr Ala Ala Gly Ile Thr Glu Gly Met Asn Glu Leu 
            580                 585                 590         


Tyr Lys 
        


<210>  18
<211>  1782
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mHTT GST-Ex1Q48-YPet

<400>  18
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tccccggaat tcatggcgac cctggaaaag      720

ctgatgaagg ccttcgagtc cctcaagtcc ttccagcagc agcagcagca gcagcagcag      780

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      840

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcaacagccg      900

ccaccgccgc cgccgccgcc gccgcctcct cagcttcctc agccgccgcc gcaggcacag      960

ccgctgctgc ctcagctgca gccgcccccg ccgccgcccc cgccgccacc cggcccggcc     1020

gcggctgagg agccgctgca ccgaccactc gagggtggcg gtggcggtat gtctaaaggt     1080

gaagaattat tcactggtgt tgtcccaatt ttggttgaat tagatggtga tgttaatggt     1140

cacaaatttt ctgtctccgg tgaaggtgaa ggtgatgcta cgtacggtaa attgacctta     1200

aaattactct gtactactgg taaattgcca gttccatggc caaccttagt cactacttta     1260

ggttatggtg ttcaatgttt tgctagatac ccagatcata tgaaacaaca tgactttttc     1320

aagtctgcca tgccagaagg ttatgttcaa gaaagaacta tttttttcaa agatgacggt     1380

aactacaaga ccagagctga agtcaagttt gaaggtgata ccttagttaa tagaatcgaa     1440

ttaaaaggta ttgattttaa agaagatggt aacattttag gtcacaaatt ggaatacaac     1500

tataactctc acaatgttta catcactgct gacaaacaaa agaatggtat caaagctaac     1560

ttcaaaatta gacacaacat tgaagatggt ggtgttcaat tagctgacca ttatcaacaa     1620

aatactccaa ttggtgatgg tccagtcttg ttaccagaca accattactt atcctatcaa     1680

tctgccttat tcaaagatcc aaacgaaaag agagaccaca tggtcttgtt agaatttttg     1740

actgctgctg gtattaccga gggtatgaat gaattgtaca aa                        1782


<210>  19
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mHTT GST-Ex1Q48-CyPet

<400>  19

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Pro Glu Phe Met Ala Thr Leu Glu Lys 
225                 230                 235                 240 


Leu Met Lys Ala Phe Glu Ser Leu Lys Ser Phe Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        275                 280                 285             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro 
    290                 295                 300                 


Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln 
305                 310                 315                 320 


Pro Leu Leu Pro Gln Leu Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro 
                325                 330                 335     


Pro Gly Pro Ala Ala Ala Glu Glu Pro Leu His Arg Pro Leu Glu Gly 
            340                 345                 350         


Gly Gly Gly Gly Met Ser Lys Gly Glu Glu Leu Phe Gly Gly Ile Val 
        355                 360                 365             


Pro Ile Leu Val Glu Leu Glu Gly Asp Val Asn Gly His Lys Phe Ser 
    370                 375                 380                 


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
385                 390                 395                 400 


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
                405                 410                 415     


Val Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp 
            420                 425                 430         


His Met Lys Gln His Asp Phe Phe Lys Ser Val Met Pro Glu Gly Tyr 
        435                 440                 445             


Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
    450                 455                 460                 


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
465                 470                 475                 480 


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
                485                 490                 495     


Leu Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys 
            500                 505                 510         


Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ala Arg His Asn Ile Thr 
        515                 520                 525             


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
    530                 535                 540                 


Gly Asp Gly Pro Val Ile Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
545                 550                 555                 560 


Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
                565                 570                 575     


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu 
            580                 585                 590         


Tyr Lys 
        


<210>  20
<211>  1782
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mHTT GST-Ex1Q48-CyPet

<400>  20
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tccccggaat tcatggcgac cctggaaaag      720

ctgatgaagg ccttcgagtc cctcaagtcc ttccagcagc agcagcagca gcagcagcag      780

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      840

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcaacagccg      900

ccaccgccgc cgcccccgcc gccgcctcct cagcttcctc agccgccgcc gcaggcacag      960

ccgctgctgc ctcagctgca gccgcccccg ccgccgcccc cgccgccacc cggcccggcc     1020

gcggctgagg agccgctgca ccgaccactc gagggtggcg gtggcggtat gtctaaaggt     1080

gaagaattat tcggcggtat cgtcccaatt ttagttgaat tagagggtga tgttaatggt     1140

cacaaatttt ctgtctccgg tgaaggtgaa ggtgatgcta cgtacggtaa attgacctta     1200

aaatttattt gtactactgg taaattgcca gttccatggc caaccttagt cactactctg     1260

acttggggtg ttcaatgttt ttctagatac ccagatcata tgaaacaaca tgactttttc     1320

aagtctgtca tgccagaagg ttatgttcaa gaaagaacta tttttttcaa agatgacggt     1380

aactacaaga ccagagctga agtcaagttt gaaggtgata ccttagttaa tagaatcgaa     1440

ttaaaaggta ttgattttaa agaagatggt aacattttag gtcacaaatt ggaatacaac     1500

tatatctctc acaatgttta catcaccgct gacaaacaaa agaatggtat caaagctaac     1560

ttcaaagcca gacacaacat taccgatggt tctgttcaat tagctgacca ttatcaacaa     1620

aatactccaa ttggtgatgg tccagtcatc ttgccagaca accattactt atccactcaa     1680

tctgccttat ctaaagatcc aaacgaaaag agagaccaca tggtcttgct cgaatttgtt     1740

actgctgctg gtattaccca tggtatggat gaattgtaca aa                        1782


<210>  21
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YPet

<400>  21

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Leu Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Gly Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Phe 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Leu 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr Glu Gly Met Asn Glu Leu Tyr Lys 
225                 230                 235             


<210>  22
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YPet

<400>  22
atgtctaaag gtgaagaatt attcactggt gttgtcccaa ttttggttga attagatggt       60

gatgttaatg gtcacaaatt ttctgtctcc ggtgaaggtg aaggtgatgc tacgtacggt      120

aaattgacct taaaattact ctgtactact ggtaaattgc cagttccatg gccaacctta      180

gtcactactt taggttatgg tgttcaatgt tttgctagat acccagatca tatgaaacaa      240

catgactttt tcaagtctgc catgccagaa ggttatgttc aagaaagaac tatttttttc      300

aaagatgacg gtaactacaa gaccagagct gaagtcaagt ttgaaggtga taccttagtt      360

aatagaatcg aattaaaagg tattgatttt aaagaagatg gtaacatttt aggtcacaaa      420

ttggaataca actataactc tcacaatgtt tacatcactg ctgacaaaca aaagaatggt      480

atcaaagcta acttcaaaat tagacacaac attgaagatg gtggtgttca attagctgac      540

cattatcaac aaaatactcc aattggtgat ggtccagtct tgttaccaga caaccattac      600

ttatcctatc aatctgcctt attcaaagat ccaaacgaaa agagagacca catggtcttg      660

ttagaatttt tgactgctgc tggtattacc gagggtatga atgaattgta caaa            714


<210>  23
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CyPet

<400>  23

Met Ser Lys Gly Glu Glu Leu Phe Gly Gly Ile Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Glu Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Val Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ala Arg His Asn Ile Thr Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Ile Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210>  24
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CyPet

<400>  24
atgtctaaag gtgaagaatt attcggcggt atcgtcccaa ttttagttga attagagggt       60

gatgttaatg gtcacaaatt ttctgtctcc ggtgaaggtg aaggtgatgc tacgtacggt      120

aaattgacct taaaatttat ttgtactact ggtaaattgc cagttccatg gccaacctta      180

gtcactactc tgacttgggg tgttcaatgt ttttctagat acccagatca tatgaaacaa      240

catgactttt tcaagtctgt catgccagaa ggttatgttc aagaaagaac tatttttttc      300

aaagatgacg gtaactacaa gaccagagct gaagtcaagt ttgaaggtga taccttagtt      360

aatagaatcg aattaaaagg tattgatttt aaagaagatg gtaacatttt aggtcacaaa      420

ttggaataca actatatctc tcacaatgtt tacatcaccg ctgacaaaca aaagaatggt      480

atcaaagcta acttcaaagc cagacacaac attaccgatg gttctgttca attagctgac      540

cattatcaac aaaatactcc aattggtgat ggtccagtca tcttgccaga caaccattac      600

ttatccactc aatctgcctt atctaaagat ccaaacgaaa agagagacca catggtcttg      660

ctcgaatttg ttactgctgc tggtattacc catggtatgg atgaattgta caaa            714


<210>  25
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu 
    50                  55                  60                  


Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro 
65                  70                  75                  80  


Ala Val Ala Glu Glu Pro Leu His Arg Pro 
                85                  90  


<210>  26
<211>  270
<212>  DNA
<213>  Homo sapiens

<400>  26
atggcgaccc tggaaaagct gatgaaggcc ttcgagtccc tcaagtcctt ccagcagcag       60

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcaacag      120

ccgccaccgc cgccgccgcc gccgccgcct cctcagcttc ctcagccgcc gccgcaggca      180

cagccgctgc tgcctcagcc gcagccgccc ccgccgccgc ccccgccgcc acccggcccg      240

gctgtggctg aggagccgct gcaccgacca                                       270


<210>  27
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-Ex1Q23

<400>  27

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Pro Glu Phe Met Ala Thr Leu Glu Lys 
225                 230                 235                 240 


Leu Met Lys Ala Phe Glu Ser Leu Lys Ser Phe Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro 
        275                 280                 285             


Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Pro Gln Pro Pro 
    290                 295                 300                 


Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Val Ala Glu Glu Pro 
305                 310                 315                 320 


Leu His Arg Pro 
                


<210>  28
<211>  972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST-Ex1Q23

<400>  28
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tccccggaat tcatggcgac cctggaaaag      720

ctgatgaagg ccttcgagtc cctcaagtcc ttccagcagc agcagcagca gcagcagcag      780

cagcagcagc agcagcagca gcagcagcag cagcagcaac agccgccacc gccgccgccg      840

ccgccgccgc ctcctcagct tcctcagccg ccgccgcagg cacagccgct gctgcctcag      900

ccgcagccgc ccccgccgcc gcccccgccg ccacccggcc cggctgtggc tgaggagccg      960

ctgcaccgac ca                                                          972


<210>  29
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-Ex1Q23-YPet

<400>  29

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Pro Glu Phe Met Ala Thr Leu Glu Lys 
225                 230                 235                 240 


Leu Met Lys Ala Phe Glu Ser Leu Lys Ser Phe Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro 
        275                 280                 285             


Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Pro Gln Pro Pro 
    290                 295                 300                 


Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Val Ala Glu Glu Pro 
305                 310                 315                 320 


Leu His Arg Pro Leu Glu Gly Gly Gly Gly Gly Met Ser Lys Gly Glu 
                325                 330                 335     


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
            340                 345                 350         


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
        355                 360                 365             


Thr Tyr Gly Lys Leu Thr Leu Lys Leu Leu Cys Thr Thr Gly Lys Leu 
    370                 375                 380                 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Val Gln 
385                 390                 395                 400 


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
                405                 410                 415     


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
            420                 425                 430         


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
        435                 440                 445             


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
    450                 455                 460                 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
465                 470                 475                 480 


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                485                 490                 495     


Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His 
            500                 505                 510         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        515                 520                 525             


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Phe Lys Asp Pro Asn Glu 
    530                 535                 540                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Leu Thr Ala Ala Gly Ile 
545                 550                 555                 560 


Thr Glu Gly Met Asn Glu Leu Tyr Lys 
                565                 


<210>  30
<211>  1707
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST-Ex1Q23-YPet

<400>  30
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tccccggaat tcatggcgac cctggaaaag      720

ctgatgaagg ccttcgagtc cctcaagtcc ttccagcagc agcagcagca gcagcagcag      780

cagcagcagc agcagcagca gcagcagcag cagcagcaac agccgccacc gccgccgccg      840

ccgccgccgc ctcctcagct tcctcagccg ccgccgcagg cacagccgct gctgcctcag      900

ccgcagccgc ccccgccgcc gcccccgccg ccacccggcc cggctgtggc tgaggagccg      960

ctgcaccgac cactcgaggg tggcggtggc ggtatgtcta aaggtgaaga attattcact     1020

ggtgttgtcc caattttggt tgaattagat ggtgatgtta atggtcacaa attttctgtc     1080

tccggtgaag gtgaaggtga tgctacgtac ggtaaattga ccttaaaatt actctgtact     1140

actggtaaat tgccagttcc atggccaacc ttagtcacta ctttaggtta tggtgttcaa     1200

tgttttgcta gatacccaga tcatatgaaa caacatgact ttttcaagtc tgccatgcca     1260

gaaggttatg ttcaagaaag aactattttt ttcaaagatg acggtaacta caagaccaga     1320

gctgaagtca agtttgaagg tgatacctta gttaatagaa tcgaattaaa aggtattgat     1380

tttaaagaag atggtaacat tttaggtcac aaattggaat acaactataa ctctcacaat     1440

gtttacatca ctgctgacaa acaaaagaat ggtatcaaag ctaacttcaa aattagacac     1500

aacattgaag atggtggtgt tcaattagct gaccattatc aacaaaatac tccaattggt     1560

gatggtccag tcttgttacc agacaaccat tacttatcct atcaatctgc cttattcaaa     1620

gatccaaacg aaaagagaga ccacatggtc ttgttagaat ttttgactgc tgctggtatt     1680

accgagggta tgaatgaatt gtacaaa                                         1707


<210>  31
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-Ex1Q23-CyPet

<400>  31

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Pro Glu Phe Met Ala Thr Leu Glu Lys 
225                 230                 235                 240 


Leu Met Lys Ala Phe Glu Ser Leu Lys Ser Phe Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro 
        275                 280                 285             


Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Pro Gln Pro Pro 
    290                 295                 300                 


Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Val Ala Glu Glu Pro 
305                 310                 315                 320 


Leu His Arg Pro Leu Glu Gly Gly Gly Gly Gly Met Ser Lys Gly Glu 
                325                 330                 335     


Glu Leu Phe Gly Gly Ile Val Pro Ile Leu Val Glu Leu Glu Gly Asp 
            340                 345                 350         


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
        355                 360                 365             


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
    370                 375                 380                 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Trp Gly Val Gln 
385                 390                 395                 400 


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
                405                 410                 415     


Ser Val Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
            420                 425                 430         


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
        435                 440                 445             


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
    450                 455                 460                 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Ile Ser His Asn 
465                 470                 475                 480 


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                485                 490                 495     


Lys Ala Arg His Asn Ile Thr Asp Gly Ser Val Gln Leu Ala Asp His 
            500                 505                 510         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Ile Leu Pro Asp 
        515                 520                 525             


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
    530                 535                 540                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
545                 550                 555                 560 


Thr His Gly Met Asp Glu Leu Tyr Lys 
                565                 


<210>  32
<211>  1707
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST-Ex1Q23-CyPet

<400>  32
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tccccggaat tcatggcgac cctggaaaag      720

ctgatgaagg ccttcgagtc cctcaagtcc ttccagcagc agcagcagca gcagcagcag      780

cagcagcagc agcagcagca gcagcagcag cagcagcaac agccgccacc gccgccgccg      840

ccgccgccgc ctcctcagct tcctcagccg ccgccgcagg cacagccgct gctgcctcag      900

ccgcagccgc ccccgccgcc gcccccgccg ccacccggcc cggctgtggc tgaggagccg      960

ctgcaccgac cactcgaggg tggcggtggc ggtatgtcta aaggtgaaga attattcggc     1020

ggtatcgtcc caattttagt tgaattagag ggtgatgtta atggtcacaa attttctgtc     1080

tccggtgaag gtgaaggtga tgctacgtac ggtaaattga ccttaaaatt tatttgtact     1140

actggtaaat tgccagttcc atggccaacc ttagtcacta ctctgacttg gggtgttcaa     1200

tgtttttcta gatacccaga tcatatgaaa caacatgact ttttcaagtc tgtcatgcca     1260

gaaggttatg ttcaagaaag aactattttt ttcaaagatg acggtaacta caagaccaga     1320

gctgaagtca agtttgaagg tgatacctta gttaatagaa tcgaattaaa aggtattgat     1380

tttaaagaag atggtaacat tttaggtcac aaattggaat acaactatat ctctcacaat     1440

gtttacatca ccgctgacaa acaaaagaat ggtatcaaag ctaacttcaa agccagacac     1500

aacattaccg atggttctgt tcaattagct gaccattatc aacaaaatac tccaattggt     1560

gatggtccag tcatcttgcc agacaaccat tacttatcca ctcaatctgc cttatctaaa     1620

gatccaaacg aaaagagaga ccacatggtc ttgctcgaat ttgttactgc tgctggtatt     1680

acccatggta tggatgaatt gtacaaa                                         1707


<210>  33
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ex1Q23-YPet

<400>  33

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu 
    50                  55                  60                  


Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro 
65                  70                  75                  80  


Ala Val Ala Glu Glu Pro Leu His Arg Pro Leu Glu Gly Gly Gly Gly 
                85                  90                  95      


Gly Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
            100                 105                 110         


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
        115                 120                 125             


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Leu 
    130                 135                 140                 


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
145                 150                 155                 160 


Leu Gly Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
                165                 170                 175     


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
            180                 185                 190         


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
        195                 200                 205             


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
    210                 215                 220                 


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
225                 230                 235                 240 


Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
                245                 250                 255     


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
            260                 265                 270         


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
        275                 280                 285             


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu 
    290                 295                 300                 


Phe Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
305                 310                 315                 320 


Leu Thr Ala Ala Gly Ile Thr Glu Gly Met Asn Glu Leu Tyr Lys 
                325                 330                 335 


<210>  34
<211>  1005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex1Q23-YPet

<400>  34
atggcgaccc tggaaaagct gatgaaggcc ttcgagtccc tcaagtcctt ccagcagcag       60

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcaacag      120

ccgccaccgc cgccgccgcc gccgccgcct cctcagcttc ctcagccgcc gccgcaggca      180

cagccgctgc tgcctcagcc gcagccgccc ccgccgccgc ccccgccgcc acccggcccg      240

gctgtggctg aggagccgct gcaccgacca ctcgagggtg gcggtggcgg tatgtctaaa      300

ggtgaagaat tattcactgg tgttgtccca attttggttg aattagatgg tgatgttaat      360

ggtcacaaat tttctgtctc cggtgaaggt gaaggtgatg ctacgtacgg taaattgacc      420

ttaaaattac tctgtactac tggtaaattg ccagttccat ggccaacctt agtcactact      480

ttaggttatg gtgttcaatg ttttgctaga tacccagatc atatgaaaca acatgacttt      540

ttcaagtctg ccatgccaga aggttatgtt caagaaagaa ctattttttt caaagatgac      600

ggtaactaca agaccagagc tgaagtcaag tttgaaggtg ataccttagt taatagaatc      660

gaattaaaag gtattgattt taaagaagat ggtaacattt taggtcacaa attggaatac      720

aactataact ctcacaatgt ttacatcact gctgacaaac aaaagaatgg tatcaaagct      780

aacttcaaaa ttagacacaa cattgaagat ggtggtgttc aattagctga ccattatcaa      840

caaaatactc caattggtga tggtccagtc ttgttaccag acaaccatta cttatcctat      900

caatctgcct tattcaaaga tccaaacgaa aagagagacc acatggtctt gttagaattt      960

ttgactgctg ctggtattac cgagggtatg aatgaattgt acaaa                     1005


<210>  35
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ex1Q23-CyPet

<400>  35

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu 
    50                  55                  60                  


Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro 
65                  70                  75                  80  


Ala Val Ala Glu Glu Pro Leu His Arg Pro Leu Glu Gly Gly Gly Gly 
                85                  90                  95      


Gly Met Ser Lys Gly Glu Glu Leu Phe Gly Gly Ile Val Pro Ile Leu 
            100                 105                 110         


Val Glu Leu Glu Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
        115                 120                 125             


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
    130                 135                 140                 


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
145                 150                 155                 160 


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
                165                 170                 175     


Gln His Asp Phe Phe Lys Ser Val Met Pro Glu Gly Tyr Val Gln Glu 
            180                 185                 190         


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
        195                 200                 205             


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
    210                 215                 220                 


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
225                 230                 235                 240 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
                245                 250                 255     


Gly Ile Lys Ala Asn Phe Lys Ala Arg His Asn Ile Thr Asp Gly Ser 
            260                 265                 270         


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
        275                 280                 285             


Pro Val Ile Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
    290                 295                 300                 


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
305                 310                 315                 320 


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
                325                 330                 335 


<210>  36
<211>  1005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ex1Q23-YPet

<400>  36
atggcgaccc tggaaaagct gatgaaggcc ttcgagtccc tcaagtcctt ccagcagcag       60

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcaacag      120

ccgccaccgc cgccgccgcc gccgccgcct cctcagcttc ctcagccgcc gccgcaggca      180

cagccgctgc tgcctcagcc gcagccgccc ccgccgccgc ccccgccgcc acccggcccg      240

gctgtggctg aggagccgct gcaccgacca ctcgagggtg gcggtggcgg tatgtctaaa      300

ggtgaagaat tattcggcgg tatcgtccca attttagttg aattagaggg tgatgttaat      360

ggtcacaaat tttctgtctc cggtgaaggt gaaggtgatg ctacgtacgg taaattgacc      420

ttaaaattta tttgtactac tggtaaattg ccagttccat ggccaacctt agtcactact      480

ctgacttggg gtgttcaatg tttttctaga tacccagatc atatgaaaca acatgacttt      540

ttcaagtctg tcatgccaga aggttatgtt caagaaagaa ctattttttt caaagatgac      600

ggtaactaca agaccagagc tgaagtcaag tttgaaggtg ataccttagt taatagaatc      660

gaattaaaag gtattgattt taaagaagat ggtaacattt taggtcacaa attggaatac      720

aactatatct ctcacaatgt ttacatcacc gctgacaaac aaaagaatgg tatcaaagct      780

aacttcaaag ccagacacaa cattaccgat ggttctgttc aattagctga ccattatcaa      840

caaaatactc caattggtga tggtccagtc atcttgccag acaaccatta cttatccact      900

caatctgcct tatctaaaga tccaaacgaa aagagagacc acatggtctt gctcgaattt      960

gttactgctg ctggtattac ccatggtatg gatgaattgt acaaa                     1005


<210>  37
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer HTTEx1Q48 fw

<400>  37
gacgacgaat tcatggcgac cctg                                              24


<210>  38
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer HTTEx1Q48 rev

<400>  38
gacgacctcg agtggtcggt gcagcgg                                           27


<210>  39
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer CyPet fw

<400>  39
acgacctcga gggtggcggt ggcggtatgt ctaaaggtga agaattattc gg               52


<210>  40
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer CyPet rev

<400>  40
gacgacgcgg ccgcttattt gtacaattca tccataccat g                           41


<210>  41
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer YPet fw

<400>  41
gacgacctcg agggtggcgg tggcggtatg tctaaaggtg aagaattatt cactgg           56


<210>  42
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer YPet rev

<400>  42
gacgacgcgg ccgcttattt gtacaattca ttcataccct cg                          42


<210>  43
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer HTTEx1Q23 fw1

<400>  43
gacgacgaat tcatggcgac cctg                                              24


<210>  44
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer HTTEx1Q23 rev1

<400>  44
gacgacgcgg ccgcctcgag tggtcggtgc agcgg                                  35


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer HTTEx1Q23 fw2

<400>  45
gacgacgaat tcatggcgac cctg                                              24


<210>  46
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer HTTEx1Q23 rev2

<400>  46
gacgacgcgg ccgcctcgag ttatggtcgg tgcagcgg                               38


<210>  47
<211>  1599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST-K2Q48P6-CYPET

<400>  47
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tccaaaaaac agcagcagca acaacagcag      720

caacagcaac aacaacaaca gcagcagcaa cagcaacagc agcagcagca acaacaacag      780

caacaacagc aacagcagca acagcagcag cagcagcaac agcaacaaca gcagcaacag      840

cagcctccgc ctccgcctcc tctcgagggt ggcggtggcg gtatgtctaa aggtgaagaa      900

ttattcggcg gtatcgtccc aattttagtt gaattagagg gtgatgttaa tggtcacaaa      960

ttttctgtct ccggtgaagg tgaaggtgat gctacgtacg gtaaattgac cttaaaattt     1020

atttgtacta ctggtaaatt gccagttcca tggccaacct tagtcactac tctgacttgg     1080

ggtgttcaat gtttttctag atacccagat catatgaaac aacatgactt tttcaagtct     1140

gtcatgccag aaggttatgt tcaagaaaga actatttttt tcaaagatga cggtaactac     1200

aagaccagag ctgaagtcaa gtttgaaggt gataccttag ttaatagaat cgaattaaaa     1260

ggtattgatt ttaaagaaga tggtaacatt ttaggtcaca aattggaata caactatatc     1320

tctcacaatg tttacatcac cgctgacaaa caaaagaatg gtatcaaagc taacttcaaa     1380

gccagacaca acattaccga tggttctgtt caattagctg accattatca acaaaatact     1440

ccaattggtg atggtccagt catcttgcca gacaaccatt acttatccac tcaatctgcc     1500

ttatctaaag atccaaacga aaagagagac cacatggtct tgctcgaatt tgttactgct     1560

gctggtatta cccatggtat ggatgaattg tacaaataa                            1599


<210>  48
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-K2Q48P6-CYPET AA

<400>  48

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Lys Lys Gln Gln Gln Gln Gln Gln Gln 
225                 230                 235                 240 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Leu 
        275                 280                 285             


Glu Gly Gly Gly Gly Gly Met Ser Lys Gly Glu Glu Leu Phe Gly Gly 
    290                 295                 300                 


Ile Val Pro Ile Leu Val Glu Leu Glu Gly Asp Val Asn Gly His Lys 
305                 310                 315                 320 


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
                325                 330                 335     


Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
            340                 345                 350         


Thr Leu Val Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr 
        355                 360                 365             


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Val Met Pro Glu 
    370                 375                 380                 


Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr 
385                 390                 395                 400 


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
                405                 410                 415     


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
            420                 425                 430         


His Lys Leu Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala 
        435                 440                 445             


Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ala Arg His Asn 
    450                 455                 460                 


Ile Thr Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
465                 470                 475                 480 


Pro Ile Gly Asp Gly Pro Val Ile Leu Pro Asp Asn His Tyr Leu Ser 
                485                 490                 495     


Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
            500                 505                 510         


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp 
        515                 520                 525             


Glu Leu Tyr Lys 
    530         


<210>  49
<211>  1599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST-K2Q48P6-YPET

<400>  49
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tccaaaaaac agcagcagca acaacagcag      720

caacagcaac aacaacaaca gcagcagcaa cagcaacagc agcagcagca acaacaacag      780

caacaacagc aacagcagca acagcagcag cagcagcaac agcaacaaca gcagcaacag      840

cagcctccgc ctccgcctcc tctcgagggt ggcggtggcg gtatgtctaa aggtgaagaa      900

ttattcactg gtgttgtccc aattttggtt gaattagatg gtgatgttaa tggtcacaaa      960

ttttctgtct ccggtgaagg tgaaggtgat gctacgtacg gtaaattgac cttaaaatta     1020

ctctgtacta ctggtaaatt gccagttcca tggccaacct tagtcactac tttaggttat     1080

ggtgttcaat gttttgctag atacccagat catatgaaac aacatgactt tttcaagtct     1140

gccatgccag aaggttatgt tcaagaaaga actatttttt tcaaagatga cggtaactac     1200

aagaccagag ctgaagtcaa gtttgaaggt gataccttag ttaatagaat cgaattaaaa     1260

ggtattgatt ttaaagaaga tggtaacatt ttaggtcaca aattggaata caactataac     1320

tctcacaatg tttacatcac tgctgacaaa caaaagaatg gtatcaaagc taacttcaaa     1380

attagacaca acattgaaga tggtggtgtt caattagctg accattatca acaaaatact     1440

ccaattggtg atggtccagt cttgttacca gacaaccatt acttatccta tcaatctgcc     1500

ttattcaaag atccaaacga aaagagagac cacatggtct tgttagaatt tttgactgct     1560

gctggtatta ccgagggtat gaatgaattg tacaaataa                            1599


<210>  50
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-K2Q48P6-YPET

<400>  50

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Lys Lys Gln Gln Gln Gln Gln Gln Gln 
225                 230                 235                 240 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Leu 
        275                 280                 285             


Glu Gly Gly Gly Gly Gly Met Ser Lys Gly Glu Glu Leu Phe Thr Gly 
    290                 295                 300                 


Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys 
305                 310                 315                 320 


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
                325                 330                 335     


Thr Leu Lys Leu Leu Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
            340                 345                 350         


Thr Leu Val Thr Thr Leu Gly Tyr Gly Val Gln Cys Phe Ala Arg Tyr 
        355                 360                 365             


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
    370                 375                 380                 


Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr 
385                 390                 395                 400 


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
                405                 410                 415     


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
            420                 425                 430         


His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala 
        435                 440                 445             


Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn 
    450                 455                 460                 


Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
465                 470                 475                 480 


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
                485                 490                 495     


Tyr Gln Ser Ala Leu Phe Lys Asp Pro Asn Glu Lys Arg Asp His Met 
            500                 505                 510         


Val Leu Leu Glu Phe Leu Thr Ala Ala Gly Ile Thr Glu Gly Met Asn 
        515                 520                 525             


Glu Leu Tyr Lys 
    530         


<210>  51
<211>  1743
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST-deltaN17Q48+6PRD-CYPET

<400>  51
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tcccagcagc agcaacaaca gcagcaacag      720

caacagcagc agcagcagca acaacagcag cagcaacagc aacaacaaca acaacagcag      780

caacaacagc aacagcagca acagcaacag cagcaacaac aacagcaaca acagcagcct      840

ccgcctccgc cacctcctcc acctccgcct ccaccgccac cgcctcctca gttacctcag      900

cctcctccgc aggcacagcc gctgctgccg cagttacagc ctccaccacc acctccgccg      960

cctccacctg gtcctgcagc agcagaagaa ccgctgcatc gtccgctcga gggtggcggt     1020

ggcggtatgt ctaaaggtga agaattattc ggcggtatcg tcccaatttt agttgaatta     1080

gagggtgatg ttaatggtca caaattttct gtctccggtg aaggtgaagg tgatgctacg     1140

tacggtaaat tgaccttaaa atttatttgt actactggta aattgccagt tccatggcca     1200

accttagtca ctactctgac ttggggtgtt caatgttttt ctagataccc agatcatatg     1260

aaacaacatg actttttcaa gtctgtcatg ccagaaggtt atgttcaaga aagaactatt     1320

tttttcaaag atgacggtaa ctacaagacc agagctgaag tcaagtttga aggtgatacc     1380

ttagttaata gaatcgaatt aaaaggtatt gattttaaag aagatggtaa cattttaggt     1440

cacaaattgg aatacaacta tatctctcac aatgtttaca tcaccgctga caaacaaaag     1500

aatggtatca aagctaactt caaagccaga cacaacatta ccgatggttc tgttcaatta     1560

gctgaccatt atcaacaaaa tactccaatt ggtgatggtc cagtcatctt gccagacaac     1620

cattacttat ccactcaatc tgccttatct aaagatccaa acgaaaagag agaccacatg     1680

gtcttgctcg aatttgttac tgctgctggt attacccatg gtatggatga attgtacaaa     1740

taa                                                                   1743


<210>  52
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-deltaN17Q48+6PRD-CYPET AA

<400>  52

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln 
225                 230                 235                 240 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        275                 280                 285             


Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln 
    290                 295                 300                 


Ala Gln Pro Leu Leu Pro Gln Leu Gln Pro Pro Pro Pro Pro Pro Pro 
305                 310                 315                 320 


Pro Pro Pro Gly Pro Ala Ala Ala Glu Glu Pro Leu His Arg Pro Leu 
                325                 330                 335     


Glu Gly Gly Gly Gly Gly Met Ser Lys Gly Glu Glu Leu Phe Gly Gly 
            340                 345                 350         


Ile Val Pro Ile Leu Val Glu Leu Glu Gly Asp Val Asn Gly His Lys 
        355                 360                 365             


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
    370                 375                 380                 


Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
385                 390                 395                 400 


Thr Leu Val Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr 
                405                 410                 415     


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Val Met Pro Glu 
            420                 425                 430         


Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr 
        435                 440                 445             


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
    450                 455                 460                 


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
465                 470                 475                 480 


His Lys Leu Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala 
                485                 490                 495     


Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ala Arg His Asn 
            500                 505                 510         


Ile Thr Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
        515                 520                 525             


Pro Ile Gly Asp Gly Pro Val Ile Leu Pro Asp Asn His Tyr Leu Ser 
    530                 535                 540                 


Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
545                 550                 555                 560 


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp 
                565                 570                 575     


Glu Leu Tyr Lys 
            580 


<210>  53
<211>  1743
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST-deltaN17Q48+6PRD-YPET

<400>  53
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tcccagcagc agcaacaaca gcagcaacag      720

caacagcagc agcagcagca acaacagcag cagcaacagc aacaacaaca acaacagcag      780

caacaacagc aacagcagca acagcaacag cagcaacaac aacagcaaca acagcagcct      840

ccgcctccgc cacctcctcc acctccgcct ccaccgccac cgcctcctca gttacctcag      900

cctcctccgc aggcacagcc gctgctgccg cagttacagc ctccaccacc acctccgccg      960

cctccacctg gtcctgcagc agcagaagaa ccgctgcatc gtccgctcga gggtggcggt     1020

ggcggtatgt ctaaaggtga agaattattc actggtgttg tcccaatttt ggttgaatta     1080

gatggtgatg ttaatggtca caaattttct gtctccggtg aaggtgaagg tgatgctacg     1140

tacggtaaat tgaccttaaa attactctgt actactggta aattgccagt tccatggcca     1200

accttagtca ctactttagg ttatggtgtt caatgttttg ctagataccc agatcatatg     1260

aaacaacatg actttttcaa gtctgccatg ccagaaggtt atgttcaaga aagaactatt     1320

tttttcaaag atgacggtaa ctacaagacc agagctgaag tcaagtttga aggtgatacc     1380

ttagttaata gaatcgaatt aaaaggtatt gattttaaag aagatggtaa cattttaggt     1440

cacaaattgg aatacaacta taactctcac aatgtttaca tcactgctga caaacaaaag     1500

aatggtatca aagctaactt caaaattaga cacaacattg aagatggtgg tgttcaatta     1560

gctgaccatt atcaacaaaa tactccaatt ggtgatggtc cagtcttgtt accagacaac     1620

cattacttat cctatcaatc tgccttattc aaagatccaa acgaaaagag agaccacatg     1680

gtcttgttag aatttttgac tgctgctggt attaccgagg gtatgaatga attgtacaaa     1740

taa                                                                   1743


<210>  54
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-deltaN17Q48+6PRD-YPET AA

<400>  54

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln 
225                 230                 235                 240 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        275                 280                 285             


Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln 
    290                 295                 300                 


Ala Gln Pro Leu Leu Pro Gln Leu Gln Pro Pro Pro Pro Pro Pro Pro 
305                 310                 315                 320 


Pro Pro Pro Gly Pro Ala Ala Ala Glu Glu Pro Leu His Arg Pro Leu 
                325                 330                 335     


Glu Gly Gly Gly Gly Gly Met Ser Lys Gly Glu Glu Leu Phe Thr Gly 
            340                 345                 350         


Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys 
        355                 360                 365             


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
    370                 375                 380                 


Thr Leu Lys Leu Leu Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
385                 390                 395                 400 


Thr Leu Val Thr Thr Leu Gly Tyr Gly Val Gln Cys Phe Ala Arg Tyr 
                405                 410                 415     


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
            420                 425                 430         


Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr 
        435                 440                 445             


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
    450                 455                 460                 


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
465                 470                 475                 480 


His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala 
                485                 490                 495     


Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn 
            500                 505                 510         


Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
        515                 520                 525             


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
    530                 535                 540                 


Tyr Gln Ser Ala Leu Phe Lys Asp Pro Asn Glu Lys Arg Asp His Met 
545                 550                 555                 560 


Val Leu Leu Glu Phe Leu Thr Ala Ala Gly Ile Thr Glu Gly Met Asn 
                565                 570                 575     


Glu Leu Tyr Lys 
            580 


<210>  55
<211>  1719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST-deltaN17Q40+6PRD-CYPET

<400>  55
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tcccagcagc agcaacaaca gcagcaacag      720

caacagcagc agcagcagca acaacagcag cagcaacagc aacaacaaca acaacagcag      780

caacaacagc aacagcagca acaacaacag caaccgcctc cgcctccgcc acctcctcca      840

ccaccaccgc cacctccgcc tccacagtta cctcagcctc cgcctcaggc acagccgctg      900

ctgccgcagt tacagcctcc tcctccccct ccacctcctc cgccaggtcc tgcagcagca      960

gaagaaccgc tgcatcgtcc gctcgagggt ggcggtggcg gtatgtctaa aggtgaagaa     1020

ttattcggcg gtatcgtccc aattttagtt gaattagagg gtgatgttaa tggtcacaaa     1080

ttttctgtct ccggtgaagg tgaaggtgat gctacgtacg gtaaattgac cttaaaattt     1140

atttgtacta ctggtaaatt gccagttcca tggccaacct tagtcactac tctgacttgg     1200

ggtgttcaat gtttttctag atacccagat catatgaaac aacatgactt tttcaagtct     1260

gtcatgccag aaggttatgt tcaagaaaga actatttttt tcaaagatga cggtaactac     1320

aagaccagag ctgaagtcaa gtttgaaggt gataccttag ttaatagaat cgaattaaaa     1380

ggtattgatt ttaaagaaga tggtaacatt ttaggtcaca aattggaata caactatatc     1440

tctcacaatg tttacatcac cgctgacaaa caaaagaatg gtatcaaagc taacttcaaa     1500

gccagacaca acattaccga tggttctgtt caattagctg accattatca acaaaatact     1560

ccaattggtg atggtccagt catcttgcca gacaaccatt acttatccac tcaatctgcc     1620

ttatctaaag atccaaacga aaagagagac cacatggtct tgctcgaatt tgttactgct     1680

gctggtatta cccatggtat ggatgaattg tacaaataa                            1719


<210>  56
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-deltaN17Q40+6PRD-CYPET AA

<400>  56

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln 
225                 230                 235                 240 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro 
            260                 265                 270         


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        275                 280                 285             


Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Leu 
    290                 295                 300                 


Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Ala Ala 
305                 310                 315                 320 


Glu Glu Pro Leu His Arg Pro Leu Glu Gly Gly Gly Gly Gly Met Ser 
                325                 330                 335     


Lys Gly Glu Glu Leu Phe Gly Gly Ile Val Pro Ile Leu Val Glu Leu 
            340                 345                 350         


Glu Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
        355                 360                 365             


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
    370                 375                 380                 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Trp 
385                 390                 395                 400 


Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
                405                 410                 415     


Phe Phe Lys Ser Val Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
            420                 425                 430         


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
        435                 440                 445             


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
    450                 455                 460                 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Ile 
465                 470                 475                 480 


Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys 
                485                 490                 495     


Ala Asn Phe Lys Ala Arg His Asn Ile Thr Asp Gly Ser Val Gln Leu 
            500                 505                 510         


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Ile 
        515                 520                 525             


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp 
    530                 535                 540                 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
545                 550                 555                 560 


Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
                565                 570         


<210>  57
<211>  1719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST-deltaN17Q40+6PRD-YPET

<400>  57
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tcccagcagc agcaacaaca gcagcaacag      720

caacagcagc agcagcagca acaacagcag cagcaacagc aacaacaaca acaacagcag      780

caacaacagc aacagcagca acaacaacag caaccgcctc cgcctccgcc acctcctcca      840

ccaccaccgc cacctccgcc tccacagtta cctcagcctc cgcctcaggc acagccgctg      900

ctgccgcagt tacagcctcc tcctccccct ccacctcctc cgccaggtcc tgcagcagca      960

gaagaaccgc tgcatcgtcc gctcgagggt ggcggtggcg gtatgtctaa aggtgaagaa     1020

ttattcactg gtgttgtccc aattttggtt gaattagatg gtgatgttaa tggtcacaaa     1080

ttttctgtct ccggtgaagg tgaaggtgat gctacgtacg gtaaattgac cttaaaatta     1140

ctctgtacta ctggtaaatt gccagttcca tggccaacct tagtcactac tttaggttat     1200

ggtgttcaat gttttgctag atacccagat catatgaaac aacatgactt tttcaagtct     1260

gccatgccag aaggttatgt tcaagaaaga actatttttt tcaaagatga cggtaactac     1320

aagaccagag ctgaagtcaa gtttgaaggt gataccttag ttaatagaat cgaattaaaa     1380

ggtattgatt ttaaagaaga tggtaacatt ttaggtcaca aattggaata caactataac     1440

tctcacaatg tttacatcac tgctgacaaa caaaagaatg gtatcaaagc taacttcaaa     1500

attagacaca acattgaaga tggtggtgtt caattagctg accattatca acaaaatact     1560

ccaattggtg atggtccagt cttgttacca gacaaccatt acttatccta tcaatctgcc     1620

ttattcaaag atccaaacga aaagagagac cacatggtct tgttagaatt tttgactgct     1680

gctggtatta ccgagggtat gaatgaattg tacaaataa                            1719


<210>  58
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-deltaN17Q40+6PRD-YPET AA

<400>  58

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln 
225                 230                 235                 240 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro 
            260                 265                 270         


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        275                 280                 285             


Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Leu 
    290                 295                 300                 


Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Ala Ala 
305                 310                 315                 320 


Glu Glu Pro Leu His Arg Pro Leu Glu Gly Gly Gly Gly Gly Met Ser 
                325                 330                 335     


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
            340                 345                 350         


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
        355                 360                 365             


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Leu Cys Thr Thr 
    370                 375                 380                 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr 
385                 390                 395                 400 


Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp 
                405                 410                 415     


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
            420                 425                 430         


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
        435                 440                 445             


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
    450                 455                 460                 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
465                 470                 475                 480 


Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys 
                485                 490                 495     


Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu 
            500                 505                 510         


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
        515                 520                 525             


Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Phe Lys Asp 
    530                 535                 540                 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Leu Thr Ala 
545                 550                 555                 560 


Ala Gly Ile Thr Glu Gly Met Asn Glu Leu Tyr Lys 
                565                 570         


<210>  59
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST-K2Q48P6

<400>  59
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tccaaaaaac agcagcagca acaacagcag      720

caacagcaac aacaacaaca gcagcagcaa cagcaacagc agcagcagca acaacaacag      780

caacaacagc aacagcagca acagcagcag cagcagcaac agcaacaaca gcagcaacag      840

cagcctccgc ctccgcctcc t                                                861


<210>  60
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-K2Q48P6 AA

<400>  60

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Lys Lys Gln Gln Gln Gln Gln Gln Gln 
225                 230                 235                 240 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro 
        275                 280                 285         


<210>  61
<211>  1005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST-deltaN17Q48+6PRD

<400>  61
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tcccagcagc agcaacaaca gcagcaacag      720

caacagcagc agcagcagca acaacagcag cagcaacagc aacaacaaca acaacagcag      780

caacaacagc aacagcagca acagcaacag cagcaacaac aacagcaaca acagcagcct      840

ccgcctccgc cacctcctcc acctccgcct ccaccgccac cgcctcctca gttacctcag      900

cctcctccgc aggcacagcc gctgctgccg cagttacagc ctccaccacc acctccgccg      960

cctccacctg gtcctgcagc agcagaagaa ccgctgcatc gtccg                     1005


<210>  62
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-deltaN17Q48+6PRD AA

<400>  62

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln 
225                 230                 235                 240 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        275                 280                 285             


Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln 
    290                 295                 300                 


Ala Gln Pro Leu Leu Pro Gln Leu Gln Pro Pro Pro Pro Pro Pro Pro 
305                 310                 315                 320 


Pro Pro Pro Gly Pro Ala Ala Ala Glu Glu Pro Leu His Arg Pro 
                325                 330                 335 


<210>  63
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST-deltaN17Q40+6PRD

<400>  63
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctggaagttc tgttccaggg gcccctggga tcccagcagc agcaacaaca gcagcaacag      720

caacagcagc agcagcagca acaacagcag cagcaacagc aacaacaaca acaacagcag      780

caacaacagc aacagcagca acaacaacag caaccgcctc cgcctccgcc acctcctcca      840

ccaccaccgc cacctccgcc tccacagtta cctcagcctc cgcctcaggc acagccgctg      900

ctgccgcagt tacagcctcc tcctccccct ccacctcctc cgccaggtcc tgcagcagca      960

gaagaaccgc tgcatcgtcc g                                                981


<210>  64
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-deltaN17Q40+6PRD AA

<400>  64

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln 
225                 230                 235                 240 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro 
            260                 265                 270         


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        275                 280                 285             


Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Leu 
    290                 295                 300                 


Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Ala Ala 
305                 310                 315                 320 


Glu Glu Pro Leu His Arg Pro 
                325         


<210>  65
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K2Q48P6-CYPET AA

<400>  65

Lys Lys Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Pro Pro Pro Pro Pro Pro Leu Glu Gly Gly Gly Gly Gly Met 
    50                  55                  60                  


Ser Lys Gly Glu Glu Leu Phe Gly Gly Ile Val Pro Ile Leu Val Glu 
65                  70                  75                  80  


Leu Glu Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
                85                  90                  95      


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
            100                 105                 110         


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
        115                 120                 125             


Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
    130                 135                 140                 


Asp Phe Phe Lys Ser Val Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
145                 150                 155                 160 


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
                165                 170                 175     


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
            180                 185                 190         


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
        195                 200                 205             


Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile 
    210                 215                 220                 


Lys Ala Asn Phe Lys Ala Arg His Asn Ile Thr Asp Gly Ser Val Gln 
225                 230                 235                 240 


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
                245                 250                 255     


Ile Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
            260                 265                 270         


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
        275                 280                 285             


Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
    290                 295                 300     


<210>  66
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K2Q48P6-YPET AA

<400>  66

Lys Lys Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Pro Pro Pro Pro Pro Pro Leu Glu Gly Gly Gly Gly Gly Met 
    50                  55                  60                  


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
65                  70                  75                  80  


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
                85                  90                  95      


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Leu Cys Thr 
            100                 105                 110         


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Gly 
        115                 120                 125             


Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His 
    130                 135                 140                 


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
145                 150                 155                 160 


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
                165                 170                 175     


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
            180                 185                 190         


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
        195                 200                 205             


Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile 
    210                 215                 220                 


Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln 
225                 230                 235                 240 


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
                245                 250                 255     


Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Phe Lys 
            260                 265                 270         


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Leu Thr 
        275                 280                 285             


Ala Ala Gly Ile Thr Glu Gly Met Asn Glu Leu Tyr Lys 
    290                 295                 300     


<210>  67
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  deltaN17Q48+6PRD-CYPET AA

<400>  67

Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
    50                  55                  60                  


Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln 
65                  70                  75                  80  


Leu Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Ala 
                85                  90                  95      


Ala Glu Glu Pro Leu His Arg Pro Leu Glu Gly Gly Gly Gly Gly Met 
            100                 105                 110         


Ser Lys Gly Glu Glu Leu Phe Gly Gly Ile Val Pro Ile Leu Val Glu 
        115                 120                 125             


Leu Glu Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
    130                 135                 140                 


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
145                 150                 155                 160 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
                165                 170                 175     


Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
            180                 185                 190         


Asp Phe Phe Lys Ser Val Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
        195                 200                 205             


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
    210                 215                 220                 


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
225                 230                 235                 240 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
                245                 250                 255     


Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile 
            260                 265                 270         


Lys Ala Asn Phe Lys Ala Arg His Asn Ile Thr Asp Gly Ser Val Gln 
        275                 280                 285             


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
    290                 295                 300                 


Ile Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
305                 310                 315                 320 


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
                325                 330                 335     


Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
            340                 345                 


<210>  68
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  deltaN17Q48+6PRD-YPET AA

<400>  68

Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
    50                  55                  60                  


Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln 
65                  70                  75                  80  


Leu Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Ala 
                85                  90                  95      


Ala Glu Glu Pro Leu His Arg Pro Leu Glu Gly Gly Gly Gly Gly Met 
            100                 105                 110         


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
        115                 120                 125             


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
    130                 135                 140                 


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Leu Cys Thr 
145                 150                 155                 160 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Gly 
                165                 170                 175     


Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His 
            180                 185                 190         


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
        195                 200                 205             


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
    210                 215                 220                 


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
225                 230                 235                 240 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
                245                 250                 255     


Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile 
            260                 265                 270         


Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln 
        275                 280                 285             


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
    290                 295                 300                 


Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Phe Lys 
305                 310                 315                 320 


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Leu Thr 
                325                 330                 335     


Ala Ala Gly Ile Thr Glu Gly Met Asn Glu Leu Tyr Lys 
            340                 345                 


<210>  69
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  deltaN17Q40+6PRD-CYPET AA

<400>  69

Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro 
    50                  55                  60                  


Gln Ala Gln Pro Leu Leu Pro Gln Leu Gln Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Pro Pro Gly Pro Ala Ala Ala Glu Glu Pro Leu His Arg Pro 
                85                  90                  95      


Leu Glu Gly Gly Gly Gly Gly Met Ser Lys Gly Glu Glu Leu Phe Gly 
            100                 105                 110         


Gly Ile Val Pro Ile Leu Val Glu Leu Glu Gly Asp Val Asn Gly His 
        115                 120                 125             


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
    130                 135                 140                 


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
145                 150                 155                 160 


Pro Thr Leu Val Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ser Arg 
                165                 170                 175     


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Val Met Pro 
            180                 185                 190         


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
        195                 200                 205             


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
    210                 215                 220                 


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
225                 230                 235                 240 


Gly His Lys Leu Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr Ile Thr 
                245                 250                 255     


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ala Arg His 
            260                 265                 270         


Asn Ile Thr Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
        275                 280                 285             


Thr Pro Ile Gly Asp Gly Pro Val Ile Leu Pro Asp Asn His Tyr Leu 
    290                 295                 300                 


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
305                 310                 315                 320 


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met 
                325                 330                 335     


Asp Glu Leu Tyr Lys 
            340     


<210>  70
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  deltaN17Q40+6PRD-YPET AA

<400>  70

Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro 
    50                  55                  60                  


Gln Ala Gln Pro Leu Leu Pro Gln Leu Gln Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Pro Pro Gly Pro Ala Ala Ala Glu Glu Pro Leu His Arg Pro 
                85                  90                  95      


Leu Glu Gly Gly Gly Gly Gly Met Ser Lys Gly Glu Glu Leu Phe Thr 
            100                 105                 110         


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
        115                 120                 125             


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
    130                 135                 140                 


Leu Thr Leu Lys Leu Leu Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
145                 150                 155                 160 


Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Val Gln Cys Phe Ala Arg 
                165                 170                 175     


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
            180                 185                 190         


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
        195                 200                 205             


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
    210                 215                 220                 


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
225                 230                 235                 240 


Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr 
                245                 250                 255     


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
            260                 265                 270         


Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
        275                 280                 285             


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
    290                 295                 300                 


Ser Tyr Gln Ser Ala Leu Phe Lys Asp Pro Asn Glu Lys Arg Asp His 
305                 310                 315                 320 


Met Val Leu Leu Glu Phe Leu Thr Ala Ala Gly Ile Thr Glu Gly Met 
                325                 330                 335     


Asn Glu Leu Tyr Lys 
            340     


<210>  71
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K2Q48P6 AA

<400>  71

Lys Lys Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Pro Pro Pro Pro Pro Pro 
    50                  55      


<210>  72
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  deltaN17Q48+6PRD AA

<400>  72

Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
    50                  55                  60                  


Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln 
65                  70                  75                  80  


Leu Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Ala 
                85                  90                  95      


Ala Glu Glu Pro Leu His Arg Pro 
            100                 


<210>  73
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  deltaN17Q40+6PRD AA

<400>  73

Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro 
    50                  55                  60                  


Gln Ala Gln Pro Leu Leu Pro Gln Leu Gln Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Pro Pro Gly Pro Ala Ala Ala Glu Glu Pro Leu His Arg Pro 
                85                  90                  95      


