                         SEQUENCE LISTING

<110>  GENETHON ET AL.
 
<120>  MINI-GDE FOR THE TREATMENT OF GLYCOGEN STORAGE DISEASE III

<130>  B2813PC00

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  1532
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly His Ser Lys Gln Ile Arg Ile Leu Leu Leu Asn Glu Met Glu 
1               5                   10                  15      


Lys Leu Glu Lys Thr Leu Phe Arg Leu Glu Gln Gly Tyr Glu Leu Gln 
            20                  25                  30          


Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val Tyr Thr 
        35                  40                  45              


Asn Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser 
    50                  55                  60                  


Leu Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp Lys Tyr 
65                  70                  75                  80  


Cys Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu 
                85                  90                  95      


Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile 
            100                 105                 110         


Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr 
        115                 120                 125             


Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu 
    130                 135                 140                 


Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe 
145                 150                 155                 160 


Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala 
                165                 170                 175     


Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr 
            180                 185                 190         


Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp 
        195                 200                 205             


Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn 
    210                 215                 220                 


Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn 
225                 230                 235                 240 


Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg 
                245                 250                 255     


Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro 
            260                 265                 270         


Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile 
        275                 280                 285             


Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val 
    290                 295                 300                 


Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu 
305                 310                 315                 320 


Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile 
                325                 330                 335     


Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile 
            340                 345                 350         


Ala Leu Thr Thr Phe Ile Pro His Asp Lys Gly Pro Ala Ala Ile Glu 
        355                 360                 365             


Glu Cys Cys Asn Trp Phe His Lys Arg Met Glu Glu Leu Asn Ser Glu 
    370                 375                 380                 


Lys His Arg Leu Ile Asn Tyr His Gln Glu Gln Ala Val Asn Cys Leu 
385                 390                 395                 400 


Leu Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His Gly Pro Lys Leu 
                405                 410                 415     


Gly Pro Val Thr Arg Lys His Pro Leu Val Thr Arg Tyr Phe Thr Phe 
            420                 425                 430         


Pro Phe Glu Glu Ile Asp Phe Ser Met Glu Glu Ser Met Ile His Leu 
        435                 440                 445             


Pro Asn Lys Ala Cys Phe Leu Met Ala His Asn Gly Trp Val Met Gly 
    450                 455                 460                 


Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu 
465                 470                 475                 480 


Arg Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly 
                485                 490                 495     


Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr 
            500                 505                 510         


Thr Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys 
        515                 520                 525             


His Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg 
    530                 535                 540                 


Asn Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser 
545                 550                 555                 560 


Glu Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu 
                565                 570                 575     


Ile Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu 
            580                 585                 590         


Val Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys 
        595                 600                 605             


Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile 
    610                 615                 620                 


Thr His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala 
625                 630                 635                 640 


Leu Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser 
                645                 650                 655     


Thr Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile Ser Val Val Ser 
            660                 665                 670         


Glu Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu Ala Leu Pro Ser Asn 
        675                 680                 685             


Thr Gly Glu Val Asn Phe Gln Ser Gly Ile Ile Ala Ala Arg Cys Ala 
    690                 695                 700                 


Ile Ser Lys Leu His Gln Glu Leu Gly Ala Lys Gly Phe Ile Gln Val 
705                 710                 715                 720 


Tyr Val Asp Gln Val Asp Glu Asp Ile Val Ala Val Thr Arg His Ser 
                725                 730                 735     


Pro Ser Ile His Gln Ser Val Val Ala Val Thr Arg Thr Ala Phe Arg 
            740                 745                 750         


Asn Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val Pro Gln Met Cys Ile 
        755                 760                 765             


Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg Thr Ile Glu Arg 
    770                 775                 780                 


Asn Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro 
785                 790                 795                 800 


Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu Asn Glu Ser Lys 
                805                 810                 815     


Ile Val Lys Gln Ala Gly Val Ala Thr Lys Gly Pro Asn Glu Tyr Ile 
            820                 825                 830         


Gln Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly Ser Val Ile Ile Phe 
        835                 840                 845             


Arg Val Ser Leu Asp Pro His Ala Gln Val Ala Val Gly Ile Leu Arg 
    850                 855                 860                 


Asn His Leu Thr Gln Phe Ser Pro His Phe Lys Ser Gly Ser Leu Ala 
865                 870                 875                 880 


Val Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro Phe Ala Ser Leu Ala 
                885                 890                 895     


Tyr Arg Leu Thr Leu Ala Glu Leu Asn Gln Ile Leu Tyr Arg Cys Glu 
            900                 905                 910         


Ser Glu Glu Lys Glu Asp Gly Gly Gly Cys Tyr Asp Ile Pro Asn Trp 
        915                 920                 925             


Ser Ala Leu Lys Tyr Ala Gly Leu Gln Gly Leu Met Ser Val Leu Ala 
    930                 935                 940                 


Glu Ile Arg Pro Lys Asn Asp Leu Gly His Pro Phe Cys Asn Asn Leu 
945                 950                 955                 960 


Arg Ser Gly Asp Trp Met Ile Asp Tyr Val Ser Asn Arg Leu Ile Ser 
                965                 970                 975     


Arg Ser Gly Thr Ile Ala Glu Val Gly Lys Trp Leu Gln Ala Met Phe 
            980                 985                 990         


Phe Tyr Leu Lys Gln Ile Pro Arg  Tyr Leu Ile Pro Cys  Tyr Phe Asp 
        995                 1000                 1005             


Ala Ile  Leu Ile Gly Ala Tyr  Thr Thr Leu Leu Asp  Thr Ala Trp 
    1010                 1015                 1020             


Lys Gln  Met Ser Ser Phe Val  Gln Asn Gly Ser Thr  Phe Val Lys 
    1025                 1030                 1035             


His Leu  Ser Leu Gly Ser Val  Gln Leu Cys Gly Val  Gly Lys Phe 
    1040                 1045                 1050             


Pro Ser  Leu Pro Ile Leu Ser  Pro Ala Leu Met Asp  Val Pro Tyr 
    1055                 1060                 1065             


Arg Leu  Asn Glu Ile Thr Lys  Glu Lys Glu Gln Cys  Cys Val Ser 
    1070                 1075                 1080             


Leu Ala  Ala Gly Leu Pro His  Phe Ser Ser Gly Ile  Phe Arg Cys 
    1085                 1090                 1095             


Trp Gly  Arg Asp Thr Phe Ile  Ala Leu Arg Gly Ile  Leu Leu Ile 
    1100                 1105                 1110             


Thr Gly  Arg Tyr Val Glu Ala  Arg Asn Ile Ile Leu  Ala Phe Ala 
    1115                 1120                 1125             


Gly Thr  Leu Arg His Gly Leu  Ile Pro Asn Leu Leu  Gly Glu Gly 
    1130                 1135                 1140             


Ile Tyr  Ala Arg Tyr Asn Cys  Arg Asp Ala Val Trp  Trp Trp Leu 
    1145                 1150                 1155             


Gln Cys  Ile Gln Asp Tyr Cys  Lys Met Val Pro Asn  Gly Leu Asp 
    1160                 1165                 1170             


Ile Leu  Lys Cys Pro Val Ser  Arg Met Tyr Pro Thr  Asp Asp Ser 
    1175                 1180                 1185             


Ala Pro  Leu Pro Ala Gly Thr  Leu Asp Gln Pro Leu  Phe Glu Val 
    1190                 1195                 1200             


Ile Gln  Glu Ala Met Gln Lys  His Met Gln Gly Ile  Gln Phe Arg 
    1205                 1210                 1215             


Glu Arg  Asn Ala Gly Pro Gln  Ile Asp Arg Asn Met  Lys Asp Glu 
    1220                 1225                 1230             


Gly Phe  Asn Ile Thr Ala Gly  Val Asp Glu Glu Thr  Gly Phe Val 
    1235                 1240                 1245             


Tyr Gly  Gly Asn Arg Phe Asn  Cys Gly Thr Trp Met  Asp Lys Met 
    1250                 1255                 1260             


Gly Glu  Ser Asp Arg Ala Arg  Asn Arg Gly Ile Pro  Ala Thr Pro 
    1265                 1270                 1275             


Arg Asp  Gly Ser Ala Val Glu  Ile Val Gly Leu Ser  Lys Ser Ala 
    1280                 1285                 1290             


Val Arg  Trp Leu Leu Glu Leu  Ser Lys Lys Asn Ile  Phe Pro Tyr 
    1295                 1300                 1305             


His Glu  Val Thr Val Lys Arg  His Gly Lys Ala Ile  Lys Val Ser 
    1310                 1315                 1320             


Tyr Asp  Glu Trp Asn Arg Lys  Ile Gln Asp Asn Phe  Glu Lys Leu 
    1325                 1330                 1335             


Phe His  Val Ser Glu Asp Pro  Ser Asp Leu Asn Glu  Lys His Pro 
    1340                 1345                 1350             


Asn Leu  Val His Lys Arg Gly  Ile Tyr Lys Asp Ser  Tyr Gly Ala 
    1355                 1360                 1365             


Ser Ser  Pro Trp Cys Asp Tyr  Gln Leu Arg Pro Asn  Phe Thr Ile 
    1370                 1375                 1380             


Ala Met  Val Val Ala Pro Glu  Leu Phe Thr Thr Glu  Lys Ala Trp 
    1385                 1390                 1395             


Lys Ala  Leu Glu Ile Ala Glu  Lys Lys Leu Leu Gly  Pro Leu Gly 
    1400                 1405                 1410             


Met Lys  Thr Leu Asp Pro Asp  Asp Met Val Tyr Cys  Gly Ile Tyr 
    1415                 1420                 1425             


Asp Asn  Ala Leu Asp Asn Asp  Asn Tyr Asn Leu Ala  Lys Gly Phe 
    1430                 1435                 1440             


Asn Tyr  His Gln Gly Pro Glu  Trp Leu Trp Pro Ile  Gly Tyr Phe 
    1445                 1450                 1455             


Leu Arg  Ala Lys Leu Tyr Phe  Ser Arg Leu Met Gly  Pro Glu Thr 
    1460                 1465                 1470             


Thr Ala  Lys Thr Ile Val Leu  Val Lys Asn Val Leu  Ser Arg His 
    1475                 1480                 1485             


Tyr Val  His Leu Glu Arg Ser  Pro Trp Lys Gly Leu  Pro Glu Leu 
    1490                 1495                 1500             


Thr Asn  Glu Asn Ala Gln Tyr  Cys Pro Phe Ser Cys  Glu Thr Gln 
    1505                 1510                 1515             


Ala Trp  Ser Ile Ala Thr Ile  Leu Glu Thr Leu Tyr  Asp Leu 
    1520                 1525                 1530         


<210>  2
<211>  1376
<212>  PRT
<213>  artificial

<220>
<223>  D1 hGDE

<400>  2

Met Ile His Phe Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys 
1               5                   10                  15      


Tyr Ser Leu Ala Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro 
            20                  25                  30          


Asn Arg Lys Tyr Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu 
        35                  40                  45              


Lys Lys Glu Trp Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His 
    50                  55                  60                  


Thr Ala Ala Asn Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr 
65                  70                  75                  80  


Asn Leu Val Asn Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg 
                85                  90                  95      


Ala Leu Trp Arg Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu 
            100                 105                 110         


Lys Gly Ile Pro Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile 
        115                 120                 125             


Arg Lys Ile Ile Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu 
    130                 135                 140                 


Phe Phe Gln Val Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu 
145                 150                 155                 160 


Leu Thr Gln Glu Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His 
                165                 170                 175     


Leu Thr Ile Ile Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val 
            180                 185                 190         


Asp Met Asn Ile Ala Leu Thr Thr Phe Ile Pro His Asp Lys Gly Pro 
        195                 200                 205             


Ala Ala Ile Glu Glu Cys Cys Asn Trp Phe His Lys Arg Met Glu Glu 
    210                 215                 220                 


Leu Asn Ser Glu Lys His Arg Leu Ile Asn Tyr His Gln Glu Gln Ala 
225                 230                 235                 240 


Val Asn Cys Leu Leu Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His 
                245                 250                 255     


Gly Pro Lys Leu Gly Pro Val Thr Arg Lys His Pro Leu Val Thr Arg 
            260                 265                 270         


Tyr Phe Thr Phe Pro Phe Glu Glu Ile Asp Phe Ser Met Glu Glu Ser 
        275                 280                 285             


Met Ile His Leu Pro Asn Lys Ala Cys Phe Leu Met Ala His Asn Gly 
    290                 295                 300                 


Trp Val Met Gly Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser 
305                 310                 315                 320 


Glu Val Tyr Leu Arg Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys 
                325                 330                 335     


Leu Arg Tyr Gly Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His 
            340                 345                 350         


Met Lys Lys Tyr Thr Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg 
        355                 360                 365             


Leu Asp Asn Cys His Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu 
    370                 375                 380                 


Asp Ala Ala Arg Asn Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu 
385                 390                 395                 400 


Phe Thr Gly Ser Glu Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly 
                405                 410                 415     


Ile Ser Ser Leu Ile Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu 
            420                 425                 430         


Glu Gly Arg Leu Val Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe 
        435                 440                 445             


Val Gln Pro Cys Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu 
    450                 455                 460                 


Phe Met Asp Ile Thr His Asp Asn Glu Cys Pro Ile Val His Arg Ser 
465                 470                 475                 480 


Ala Tyr Asp Ala Leu Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys 
                485                 490                 495     


Ala Ser Gly Ser Thr Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile 
            500                 505                 510         


Ser Val Val Ser Glu Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu Ala 
        515                 520                 525             


Leu Pro Ser Asn Thr Gly Glu Val Asn Phe Gln Ser Gly Ile Ile Ala 
    530                 535                 540                 


Ala Arg Cys Ala Ile Ser Lys Leu His Gln Glu Leu Gly Ala Lys Gly 
545                 550                 555                 560 


Phe Ile Gln Val Tyr Val Asp Gln Val Asp Glu Asp Ile Val Ala Val 
                565                 570                 575     


Thr Arg His Ser Pro Ser Ile His Gln Ser Val Val Ala Val Thr Arg 
            580                 585                 590         


Thr Ala Phe Arg Asn Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val Pro 
        595                 600                 605             


Gln Met Cys Ile Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg 
    610                 615                 620                 


Thr Ile Glu Arg Asn Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser Ile 
625                 630                 635                 640 


Asn Gly Thr Pro Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu 
                645                 650                 655     


Asn Glu Ser Lys Ile Val Lys Gln Ala Gly Val Ala Thr Lys Gly Pro 
            660                 665                 670         


Asn Glu Tyr Ile Gln Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly Ser 
        675                 680                 685             


Val Ile Ile Phe Arg Val Ser Leu Asp Pro His Ala Gln Val Ala Val 
    690                 695                 700                 


Gly Ile Leu Arg Asn His Leu Thr Gln Phe Ser Pro His Phe Lys Ser 
705                 710                 715                 720 


Gly Ser Leu Ala Val Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro Phe 
                725                 730                 735     


Ala Ser Leu Ala Tyr Arg Leu Thr Leu Ala Glu Leu Asn Gln Ile Leu 
            740                 745                 750         


Tyr Arg Cys Glu Ser Glu Glu Lys Glu Asp Gly Gly Gly Cys Tyr Asp 
        755                 760                 765             


Ile Pro Asn Trp Ser Ala Leu Lys Tyr Ala Gly Leu Gln Gly Leu Met 
    770                 775                 780                 


Ser Val Leu Ala Glu Ile Arg Pro Lys Asn Asp Leu Gly His Pro Phe 
785                 790                 795                 800 


Cys Asn Asn Leu Arg Ser Gly Asp Trp Met Ile Asp Tyr Val Ser Asn 
                805                 810                 815     


Arg Leu Ile Ser Arg Ser Gly Thr Ile Ala Glu Val Gly Lys Trp Leu 
            820                 825                 830         


Gln Ala Met Phe Phe Tyr Leu Lys Gln Ile Pro Arg Tyr Leu Ile Pro 
        835                 840                 845             


Cys Tyr Phe Asp Ala Ile Leu Ile Gly Ala Tyr Thr Thr Leu Leu Asp 
    850                 855                 860                 


Thr Ala Trp Lys Gln Met Ser Ser Phe Val Gln Asn Gly Ser Thr Phe 
865                 870                 875                 880 


Val Lys His Leu Ser Leu Gly Ser Val Gln Leu Cys Gly Val Gly Lys 
                885                 890                 895     


Phe Pro Ser Leu Pro Ile Leu Ser Pro Ala Leu Met Asp Val Pro Tyr 
            900                 905                 910         


Arg Leu Asn Glu Ile Thr Lys Glu Lys Glu Gln Cys Cys Val Ser Leu 
        915                 920                 925             


Ala Ala Gly Leu Pro His Phe Ser Ser Gly Ile Phe Arg Cys Trp Gly 
    930                 935                 940                 


Arg Asp Thr Phe Ile Ala Leu Arg Gly Ile Leu Leu Ile Thr Gly Arg 
945                 950                 955                 960 


Tyr Val Glu Ala Arg Asn Ile Ile Leu Ala Phe Ala Gly Thr Leu Arg 
                965                 970                 975     


His Gly Leu Ile Pro Asn Leu Leu Gly Glu Gly Ile Tyr Ala Arg Tyr 
            980                 985                 990         


Asn Cys Arg Asp Ala Val Trp Trp  Trp Leu Gln Cys Ile  Gln Asp Tyr 
        995                 1000                 1005             


Cys Lys  Met Val Pro Asn Gly  Leu Asp Ile Leu Lys  Cys Pro Val 
    1010                 1015                 1020             


Ser Arg  Met Tyr Pro Thr Asp  Asp Ser Ala Pro Leu  Pro Ala Gly 
    1025                 1030                 1035             


Thr Leu  Asp Gln Pro Leu Phe  Glu Val Ile Gln Glu  Ala Met Gln 
    1040                 1045                 1050             


Lys His  Met Gln Gly Ile Gln  Phe Arg Glu Arg Asn  Ala Gly Pro 
    1055                 1060                 1065             


Gln Ile  Asp Arg Asn Met Lys  Asp Glu Gly Phe Asn  Ile Thr Ala 
    1070                 1075                 1080             


Gly Val  Asp Glu Glu Thr Gly  Phe Val Tyr Gly Gly  Asn Arg Phe 
    1085                 1090                 1095             


Asn Cys  Gly Thr Trp Met Asp  Lys Met Gly Glu Ser  Asp Arg Ala 
    1100                 1105                 1110             


Arg Asn  Arg Gly Ile Pro Ala  Thr Pro Arg Asp Gly  Ser Ala Val 
    1115                 1120                 1125             


Glu Ile  Val Gly Leu Ser Lys  Ser Ala Val Arg Trp  Leu Leu Glu 
    1130                 1135                 1140             


Leu Ser  Lys Lys Asn Ile Phe  Pro Tyr His Glu Val  Thr Val Lys 
    1145                 1150                 1155             


Arg His  Gly Lys Ala Ile Lys  Val Ser Tyr Asp Glu  Trp Asn Arg 
    1160                 1165                 1170             


Lys Ile  Gln Asp Asn Phe Glu  Lys Leu Phe His Val  Ser Glu Asp 
    1175                 1180                 1185             


Pro Ser  Asp Leu Asn Glu Lys  His Pro Asn Leu Val  His Lys Arg 
    1190                 1195                 1200             


Gly Ile  Tyr Lys Asp Ser Tyr  Gly Ala Ser Ser Pro  Trp Cys Asp 
    1205                 1210                 1215             


Tyr Gln  Leu Arg Pro Asn Phe  Thr Ile Ala Met Val  Val Ala Pro 
    1220                 1225                 1230             


Glu Leu  Phe Thr Thr Glu Lys  Ala Trp Lys Ala Leu  Glu Ile Ala 
    1235                 1240                 1245             


Glu Lys  Lys Leu Leu Gly Pro  Leu Gly Met Lys Thr  Leu Asp Pro 
    1250                 1255                 1260             


Asp Asp  Met Val Tyr Cys Gly  Ile Tyr Asp Asn Ala  Leu Asp Asn 
    1265                 1270                 1275             


Asp Asn  Tyr Asn Leu Ala Lys  Gly Phe Asn Tyr His  Gln Gly Pro 
    1280                 1285                 1290             


Glu Trp  Leu Trp Pro Ile Gly  Tyr Phe Leu Arg Ala  Lys Leu Tyr 
    1295                 1300                 1305             


Phe Ser  Arg Leu Met Gly Pro  Glu Thr Thr Ala Lys  Thr Ile Val 
    1310                 1315                 1320             


Leu Val  Lys Asn Val Leu Ser  Arg His Tyr Val His  Leu Glu Arg 
    1325                 1330                 1335             


Ser Pro  Trp Lys Gly Leu Pro  Glu Leu Thr Asn Glu  Asn Ala Gln 
    1340                 1345                 1350             


Tyr Cys  Pro Phe Ser Cys Glu  Thr Gln Ala Trp Ser  Ile Ala Thr 
    1355                 1360                 1365             


Ile Leu  Glu Thr Leu Tyr Asp  Leu 
    1370                 1375     


<210>  3
<211>  1464
<212>  PRT
<213>  artificial

<220>
<223>  D2 hGDE

<400>  3

Met Gly His Ser Lys Gln Ile Arg Ile Leu Leu Leu Asn Glu Met Glu 
1               5                   10                  15      


Lys Leu Glu Lys Thr Leu Phe Arg Leu Glu Gln Gly Tyr Glu Leu Gln 
            20                  25                  30          


Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val Tyr Thr 
        35                  40                  45              


Asn Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser 
    50                  55                  60                  


Leu Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp Lys Tyr 
65                  70                  75                  80  


Cys Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu 
                85                  90                  95      


Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile 
            100                 105                 110         


Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr 
        115                 120                 125             


Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu 
    130                 135                 140                 


Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe 
145                 150                 155                 160 


Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala 
                165                 170                 175     


Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr 
            180                 185                 190         


Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp 
        195                 200                 205             


Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn 
    210                 215                 220                 


Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn 
225                 230                 235                 240 


Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg 
                245                 250                 255     


Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro 
            260                 265                 270         


Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile 
        275                 280                 285             


Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val 
    290                 295                 300                 


Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu 
305                 310                 315                 320 


Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile 
                325                 330                 335     


Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile 
            340                 345                 350         


Ala Leu Thr Thr Phe Ile Pro His Tyr Phe Thr Phe Pro Phe Glu Glu 
        355                 360                 365             


Ile Asp Phe Ser Met Glu Glu Ser Met Ile His Leu Pro Asn Lys Ala 
    370                 375                 380                 


Cys Phe Leu Met Ala His Asn Gly Trp Val Met Gly Asp Asp Pro Leu 
385                 390                 395                 400 


Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu Arg Arg Glu Leu 
                405                 410                 415     


Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly Asn Lys Pro Glu 
            420                 425                 430         


Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr Thr Glu Ile Thr 
        435                 440                 445             


Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys His Ser Thr Pro 
    450                 455                 460                 


Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg Asn Leu Gln Pro 
465                 470                 475                 480 


Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser Glu Asp Leu Asp 
                485                 490                 495     


Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu Ile Arg Glu Ala 
            500                 505                 510         


Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu Val Tyr Arg Tyr 
        515                 520                 525             


Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys Leu Arg Pro Leu 
    530                 535                 540                 


Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile Thr His Asp Asn 
545                 550                 555                 560 


Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala Leu Pro Ser Thr 
                565                 570                 575     


Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser Thr Arg Gly Tyr 
            580                 585                 590         


Asp Glu Leu Val Pro His Gln Ile Ser Val Val Ser Glu Glu Arg Phe 
        595                 600                 605             


Tyr Thr Lys Trp Asn Pro Glu Ala Leu Pro Ser Asn Thr Gly Glu Val 
    610                 615                 620                 


Asn Phe Gln Ser Gly Ile Ile Ala Ala Arg Cys Ala Ile Ser Lys Leu 
625                 630                 635                 640 


His Gln Glu Leu Gly Ala Lys Gly Phe Ile Gln Val Tyr Val Asp Gln 
                645                 650                 655     


Val Asp Glu Asp Ile Val Ala Val Thr Arg His Ser Pro Ser Ile His 
            660                 665                 670         


Gln Ser Val Val Ala Val Thr Arg Thr Ala Phe Arg Asn Pro Lys Thr 
        675                 680                 685             


Ser Phe Tyr Ser Lys Glu Val Pro Gln Met Cys Ile Pro Gly Lys Ile 
    690                 695                 700                 


Glu Glu Val Val Leu Glu Ala Arg Thr Ile Glu Arg Asn Thr Lys Pro 
705                 710                 715                 720 


Tyr Arg Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro Asp Ile Thr Val 
                725                 730                 735     


Glu Ile Arg Glu His Ile Gln Leu Asn Glu Ser Lys Ile Val Lys Gln 
            740                 745                 750         


Ala Gly Val Ala Thr Lys Gly Pro Asn Glu Tyr Ile Gln Glu Ile Glu 
        755                 760                 765             


Phe Glu Asn Leu Ser Pro Gly Ser Val Ile Ile Phe Arg Val Ser Leu 
    770                 775                 780                 


Asp Pro His Ala Gln Val Ala Val Gly Ile Leu Arg Asn His Leu Thr 
785                 790                 795                 800 


Gln Phe Ser Pro His Phe Lys Ser Gly Ser Leu Ala Val Asp Asn Ala 
                805                 810                 815     


Asp Pro Ile Leu Lys Ile Pro Phe Ala Ser Leu Ala Tyr Arg Leu Thr 
            820                 825                 830         


Leu Ala Glu Leu Asn Gln Ile Leu Tyr Arg Cys Glu Ser Glu Glu Lys 
        835                 840                 845             


Glu Asp Gly Gly Gly Cys Tyr Asp Ile Pro Asn Trp Ser Ala Leu Lys 
    850                 855                 860                 


Tyr Ala Gly Leu Gln Gly Leu Met Ser Val Leu Ala Glu Ile Arg Pro 
865                 870                 875                 880 


Lys Asn Asp Leu Gly His Pro Phe Cys Asn Asn Leu Arg Ser Gly Asp 
                885                 890                 895     


Trp Met Ile Asp Tyr Val Ser Asn Arg Leu Ile Ser Arg Ser Gly Thr 
            900                 905                 910         


Ile Ala Glu Val Gly Lys Trp Leu Gln Ala Met Phe Phe Tyr Leu Lys 
        915                 920                 925             


Gln Ile Pro Arg Tyr Leu Ile Pro Cys Tyr Phe Asp Ala Ile Leu Ile 
    930                 935                 940                 


Gly Ala Tyr Thr Thr Leu Leu Asp Thr Ala Trp Lys Gln Met Ser Ser 
945                 950                 955                 960 


Phe Val Gln Asn Gly Ser Thr Phe Val Lys His Leu Ser Leu Gly Ser 
                965                 970                 975     


Val Gln Leu Cys Gly Val Gly Lys Phe Pro Ser Leu Pro Ile Leu Ser 
            980                 985                 990         


Pro Ala Leu Met Asp Val Pro Tyr  Arg Leu Asn Glu Ile  Thr Lys Glu 
        995                 1000                 1005             


Lys Glu  Gln Cys Cys Val Ser  Leu Ala Ala Gly Leu  Pro His Phe 
    1010                 1015                 1020             


Ser Ser  Gly Ile Phe Arg Cys  Trp Gly Arg Asp Thr  Phe Ile Ala 
    1025                 1030                 1035             


Leu Arg  Gly Ile Leu Leu Ile  Thr Gly Arg Tyr Val  Glu Ala Arg 
    1040                 1045                 1050             


Asn Ile  Ile Leu Ala Phe Ala  Gly Thr Leu Arg His  Gly Leu Ile 
    1055                 1060                 1065             


Pro Asn  Leu Leu Gly Glu Gly  Ile Tyr Ala Arg Tyr  Asn Cys Arg 
    1070                 1075                 1080             


Asp Ala  Val Trp Trp Trp Leu  Gln Cys Ile Gln Asp  Tyr Cys Lys 
    1085                 1090                 1095             


Met Val  Pro Asn Gly Leu Asp  Ile Leu Lys Cys Pro  Val Ser Arg 
    1100                 1105                 1110             


Met Tyr  Pro Thr Asp Asp Ser  Ala Pro Leu Pro Ala  Gly Thr Leu 
    1115                 1120                 1125             


Asp Gln  Pro Leu Phe Glu Val  Ile Gln Glu Ala Met  Gln Lys His 
    1130                 1135                 1140             


Met Gln  Gly Ile Gln Phe Arg  Glu Arg Asn Ala Gly  Pro Gln Ile 
    1145                 1150                 1155             


Asp Arg  Asn Met Lys Asp Glu  Gly Phe Asn Ile Thr  Ala Gly Val 
    1160                 1165                 1170             


Asp Glu  Glu Thr Gly Phe Val  Tyr Gly Gly Asn Arg  Phe Asn Cys 
    1175                 1180                 1185             


Gly Thr  Trp Met Asp Lys Met  Gly Glu Ser Asp Arg  Ala Arg Asn 
    1190                 1195                 1200             


Arg Gly  Ile Pro Ala Thr Pro  Arg Asp Gly Ser Ala  Val Glu Ile 
    1205                 1210                 1215             


Val Gly  Leu Ser Lys Ser Ala  Val Arg Trp Leu Leu  Glu Leu Ser 
    1220                 1225                 1230             


Lys Lys  Asn Ile Phe Pro Tyr  His Glu Val Thr Val  Lys Arg His 
    1235                 1240                 1245             


Gly Lys  Ala Ile Lys Val Ser  Tyr Asp Glu Trp Asn  Arg Lys Ile 
    1250                 1255                 1260             


Gln Asp  Asn Phe Glu Lys Leu  Phe His Val Ser Glu  Asp Pro Ser 
    1265                 1270                 1275             


Asp Leu  Asn Glu Lys His Pro  Asn Leu Val His Lys  Arg Gly Ile 
    1280                 1285                 1290             


Tyr Lys  Asp Ser Tyr Gly Ala  Ser Ser Pro Trp Cys  Asp Tyr Gln 
    1295                 1300                 1305             


Leu Arg  Pro Asn Phe Thr Ile  Ala Met Val Val Ala  Pro Glu Leu 
    1310                 1315                 1320             


Phe Thr  Thr Glu Lys Ala Trp  Lys Ala Leu Glu Ile  Ala Glu Lys 
    1325                 1330                 1335             


Lys Leu  Leu Gly Pro Leu Gly  Met Lys Thr Leu Asp  Pro Asp Asp 
    1340                 1345                 1350             


Met Val  Tyr Cys Gly Ile Tyr  Asp Asn Ala Leu Asp  Asn Asp Asn 
    1355                 1360                 1365             


Tyr Asn  Leu Ala Lys Gly Phe  Asn Tyr His Gln Gly  Pro Glu Trp 
    1370                 1375                 1380             


Leu Trp  Pro Ile Gly Tyr Phe  Leu Arg Ala Lys Leu  Tyr Phe Ser 
    1385                 1390                 1395             


Arg Leu  Met Gly Pro Glu Thr  Thr Ala Lys Thr Ile  Val Leu Val 
    1400                 1405                 1410             


Lys Asn  Val Leu Ser Arg His  Tyr Val His Leu Glu  Arg Ser Pro 
    1415                 1420                 1425             


Trp Lys  Gly Leu Pro Glu Leu  Thr Asn Glu Asn Ala  Gln Tyr Cys 
    1430                 1435                 1440             


Pro Phe  Ser Cys Glu Thr Gln  Ala Trp Ser Ile Ala  Thr Ile Leu 
    1445                 1450                 1455             


Glu Thr  Leu Tyr Asp Leu 
    1460                 


<210>  4
<211>  1430
<212>  PRT
<213>  artificial

<220>
<223>  D3 hGDE

<400>  4

Met Gly His Ser Lys Gln Ile Arg Ile Leu Leu Leu Asn Glu Met Glu 
1               5                   10                  15      


Lys Leu Glu Lys Thr Leu Phe Arg Leu Glu Gln Gly Tyr Glu Leu Gln 
            20                  25                  30          


Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val Tyr Thr 
        35                  40                  45              


Asn Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser 
    50                  55                  60                  


Leu Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp Lys Tyr 
65                  70                  75                  80  


Cys Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu 
                85                  90                  95      


Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile 
            100                 105                 110         


Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr 
        115                 120                 125             


Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu 
    130                 135                 140                 


Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe 
145                 150                 155                 160 


Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala 
                165                 170                 175     


Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr 
            180                 185                 190         


Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp 
        195                 200                 205             


Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn 
    210                 215                 220                 


Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn 
225                 230                 235                 240 


Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg 
                245                 250                 255     


Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro 
            260                 265                 270         


Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile 
        275                 280                 285             


Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val 
    290                 295                 300                 


Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu 
305                 310                 315                 320 


Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile 
                325                 330                 335     


Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile 
            340                 345                 350         


Ala Leu Thr Thr Phe Ile Pro His Asp Lys Gly Pro Ala Ala Ile Glu 
        355                 360                 365             


Glu Cys Cys Asn Trp Phe His Lys Arg Met Glu Glu Leu Asn Ser Glu 
    370                 375                 380                 


Lys His Arg Leu Ile Asn Tyr His Gln Glu Gln Ala Val Asn Cys Leu 
385                 390                 395                 400 


Leu Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His Gly Pro Lys Leu 
                405                 410                 415     


Gly Pro Val Thr Arg Lys His Pro Leu Val Thr Arg Tyr Phe Thr Phe 
            420                 425                 430         


Pro Phe Glu Glu Ile Asp Phe Ser Met Glu Glu Ser Met Ile His Leu 
        435                 440                 445             


Pro Asn Lys Ala Cys Phe Leu Met Ala His Asn Gly Trp Val Met Gly 
    450                 455                 460                 


Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu 
465                 470                 475                 480 


Arg Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly 
                485                 490                 495     


Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr 
            500                 505                 510         


Thr Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys 
        515                 520                 525             


His Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg 
    530                 535                 540                 


Asn Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser 
545                 550                 555                 560 


Glu Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu 
                565                 570                 575     


Ile Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu 
            580                 585                 590         


Val Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys 
        595                 600                 605             


Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile 
    610                 615                 620                 


Thr His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala 
625                 630                 635                 640 


Leu Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser 
                645                 650                 655     


Thr Arg Gly Tyr Asp Glu Leu Val Pro His Gln Gly Lys Ile Glu Glu 
            660                 665                 670         


Val Val Leu Glu Ala Arg Thr Ile Glu Arg Asn Thr Lys Pro Tyr Arg 
        675                 680                 685             


Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro Asp Ile Thr Val Glu Ile 
    690                 695                 700                 


Arg Glu His Ile Gln Leu Asn Glu Ser Lys Ile Val Lys Gln Ala Gly 
705                 710                 715                 720 


Val Ala Thr Lys Gly Pro Asn Glu Tyr Ile Gln Glu Ile Glu Phe Glu 
                725                 730                 735     


Asn Leu Ser Pro Gly Ser Val Ile Ile Phe Arg Val Ser Leu Asp Pro 
            740                 745                 750         


His Ala Gln Val Ala Val Gly Ile Leu Arg Asn His Leu Thr Gln Phe 
        755                 760                 765             


Ser Pro His Phe Lys Ser Gly Ser Leu Ala Val Asp Asn Ala Asp Pro 
    770                 775                 780                 


Ile Leu Lys Ile Pro Phe Ala Ser Leu Ala Tyr Arg Leu Thr Leu Ala 
785                 790                 795                 800 


Glu Leu Asn Gln Ile Leu Tyr Arg Cys Glu Ser Glu Glu Lys Glu Asp 
                805                 810                 815     


Gly Gly Gly Cys Tyr Asp Ile Pro Asn Trp Ser Ala Leu Lys Tyr Ala 
            820                 825                 830         


Gly Leu Gln Gly Leu Met Ser Val Leu Ala Glu Ile Arg Pro Lys Asn 
        835                 840                 845             


Asp Leu Gly His Pro Phe Cys Asn Asn Leu Arg Ser Gly Asp Trp Met 
    850                 855                 860                 


Ile Asp Tyr Val Ser Asn Arg Leu Ile Ser Arg Ser Gly Thr Ile Ala 
865                 870                 875                 880 


Glu Val Gly Lys Trp Leu Gln Ala Met Phe Phe Tyr Leu Lys Gln Ile 
                885                 890                 895     


Pro Arg Tyr Leu Ile Pro Cys Tyr Phe Asp Ala Ile Leu Ile Gly Ala 
            900                 905                 910         


Tyr Thr Thr Leu Leu Asp Thr Ala Trp Lys Gln Met Ser Ser Phe Val 
        915                 920                 925             


Gln Asn Gly Ser Thr Phe Val Lys His Leu Ser Leu Gly Ser Val Gln 
    930                 935                 940                 


Leu Cys Gly Val Gly Lys Phe Pro Ser Leu Pro Ile Leu Ser Pro Ala 
945                 950                 955                 960 


Leu Met Asp Val Pro Tyr Arg Leu Asn Glu Ile Thr Lys Glu Lys Glu 
                965                 970                 975     


Gln Cys Cys Val Ser Leu Ala Ala Gly Leu Pro His Phe Ser Ser Gly 
            980                 985                 990         


Ile Phe Arg Cys Trp Gly Arg Asp  Thr Phe Ile Ala Leu  Arg Gly Ile 
        995                 1000                 1005             


Leu Leu  Ile Thr Gly Arg Tyr  Val Glu Ala Arg Asn  Ile Ile Leu 
    1010                 1015                 1020             


Ala Phe  Ala Gly Thr Leu Arg  His Gly Leu Ile Pro  Asn Leu Leu 
    1025                 1030                 1035             


Gly Glu  Gly Ile Tyr Ala Arg  Tyr Asn Cys Arg Asp  Ala Val Trp 
    1040                 1045                 1050             


Trp Trp  Leu Gln Cys Ile Gln  Asp Tyr Cys Lys Met  Val Pro Asn 
    1055                 1060                 1065             


Gly Leu  Asp Ile Leu Lys Cys  Pro Val Ser Arg Met  Tyr Pro Thr 
    1070                 1075                 1080             


Asp Asp  Ser Ala Pro Leu Pro  Ala Gly Thr Leu Asp  Gln Pro Leu 
    1085                 1090                 1095             


Phe Glu  Val Ile Gln Glu Ala  Met Gln Lys His Met  Gln Gly Ile 
    1100                 1105                 1110             


Gln Phe  Arg Glu Arg Asn Ala  Gly Pro Gln Ile Asp  Arg Asn Met 
    1115                 1120                 1125             


Lys Asp  Glu Gly Phe Asn Ile  Thr Ala Gly Val Asp  Glu Glu Thr 
    1130                 1135                 1140             


Gly Phe  Val Tyr Gly Gly Asn  Arg Phe Asn Cys Gly  Thr Trp Met 
    1145                 1150                 1155             


Asp Lys  Met Gly Glu Ser Asp  Arg Ala Arg Asn Arg  Gly Ile Pro 
    1160                 1165                 1170             


Ala Thr  Pro Arg Asp Gly Ser  Ala Val Glu Ile Val  Gly Leu Ser 
    1175                 1180                 1185             


Lys Ser  Ala Val Arg Trp Leu  Leu Glu Leu Ser Lys  Lys Asn Ile 
    1190                 1195                 1200             


Phe Pro  Tyr His Glu Val Thr  Val Lys Arg His Gly  Lys Ala Ile 
    1205                 1210                 1215             


Lys Val  Ser Tyr Asp Glu Trp  Asn Arg Lys Ile Gln  Asp Asn Phe 
    1220                 1225                 1230             


Glu Lys  Leu Phe His Val Ser  Glu Asp Pro Ser Asp  Leu Asn Glu 
    1235                 1240                 1245             


Lys His  Pro Asn Leu Val His  Lys Arg Gly Ile Tyr  Lys Asp Ser 
    1250                 1255                 1260             


Tyr Gly  Ala Ser Ser Pro Trp  Cys Asp Tyr Gln Leu  Arg Pro Asn 
    1265                 1270                 1275             


Phe Thr  Ile Ala Met Val Val  Ala Pro Glu Leu Phe  Thr Thr Glu 
    1280                 1285                 1290             


Lys Ala  Trp Lys Ala Leu Glu  Ile Ala Glu Lys Lys  Leu Leu Gly 
    1295                 1300                 1305             


Pro Leu  Gly Met Lys Thr Leu  Asp Pro Asp Asp Met  Val Tyr Cys 
    1310                 1315                 1320             


Gly Ile  Tyr Asp Asn Ala Leu  Asp Asn Asp Asn Tyr  Asn Leu Ala 
    1325                 1330                 1335             


Lys Gly  Phe Asn Tyr His Gln  Gly Pro Glu Trp Leu  Trp Pro Ile 
    1340                 1345                 1350             


Gly Tyr  Phe Leu Arg Ala Lys  Leu Tyr Phe Ser Arg  Leu Met Gly 
    1355                 1360                 1365             


Pro Glu  Thr Thr Ala Lys Thr  Ile Val Leu Val Lys  Asn Val Leu 
    1370                 1375                 1380             


Ser Arg  His Tyr Val His Leu  Glu Arg Ser Pro Trp  Lys Gly Leu 
    1385                 1390                 1395             


Pro Glu  Leu Thr Asn Glu Asn  Ala Gln Tyr Cys Pro  Phe Ser Cys 
    1400                 1405                 1410             


Glu Thr  Gln Ala Trp Ser Ile  Ala Thr Ile Leu Glu  Thr Leu Tyr 
    1415                 1420                 1425             


Asp Leu  
    1430 


<210>  5
<211>  1362
<212>  PRT
<213>  artificial

<220>
<223>  D2,3 hGDE

<400>  5

Met Gly His Ser Lys Gln Ile Arg Ile Leu Leu Leu Asn Glu Met Glu 
1               5                   10                  15      


Lys Leu Glu Lys Thr Leu Phe Arg Leu Glu Gln Gly Tyr Glu Leu Gln 
            20                  25                  30          


Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val Tyr Thr 
        35                  40                  45              


Asn Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser 
    50                  55                  60                  


Leu Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp Lys Tyr 
65                  70                  75                  80  


Cys Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu 
                85                  90                  95      


Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile 
            100                 105                 110         


Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr 
        115                 120                 125             


Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu 
    130                 135                 140                 


Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe 
145                 150                 155                 160 


Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala 
                165                 170                 175     


Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr 
            180                 185                 190         


Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp 
        195                 200                 205             


Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn 
    210                 215                 220                 


Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn 
225                 230                 235                 240 


Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg 
                245                 250                 255     


Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro 
            260                 265                 270         


Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile 
        275                 280                 285             


Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val 
    290                 295                 300                 


Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu 
305                 310                 315                 320 


Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile 
                325                 330                 335     


Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile 
            340                 345                 350         


Ala Leu Thr Thr Phe Ile Pro His Tyr Phe Thr Phe Pro Phe Glu Glu 
        355                 360                 365             


Ile Asp Phe Ser Met Glu Glu Ser Met Ile His Leu Pro Asn Lys Ala 
    370                 375                 380                 


Cys Phe Leu Met Ala His Asn Gly Trp Val Met Gly Asp Asp Pro Leu 
385                 390                 395                 400 


Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu Arg Arg Glu Leu 
                405                 410                 415     


Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly Asn Lys Pro Glu 
            420                 425                 430         


Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr Thr Glu Ile Thr 
        435                 440                 445             


Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys His Ser Thr Pro 
    450                 455                 460                 


Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg Asn Leu Gln Pro 
465                 470                 475                 480 


Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser Glu Asp Leu Asp 
                485                 490                 495     


Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu Ile Arg Glu Ala 
            500                 505                 510         


Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu Val Tyr Arg Tyr 
        515                 520                 525             


Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys Leu Arg Pro Leu 
    530                 535                 540                 


Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile Thr His Asp Asn 
545                 550                 555                 560 


Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala Leu Pro Ser Thr 
                565                 570                 575     


Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser Thr Arg Gly Tyr 
            580                 585                 590         


Asp Glu Leu Val Pro His Gln Gly Lys Ile Glu Glu Val Val Leu Glu 
        595                 600                 605             


Ala Arg Thr Ile Glu Arg Asn Thr Lys Pro Tyr Arg Lys Asp Glu Asn 
    610                 615                 620                 


Ser Ile Asn Gly Thr Pro Asp Ile Thr Val Glu Ile Arg Glu His Ile 
625                 630                 635                 640 


Gln Leu Asn Glu Ser Lys Ile Val Lys Gln Ala Gly Val Ala Thr Lys 
                645                 650                 655     


Gly Pro Asn Glu Tyr Ile Gln Glu Ile Glu Phe Glu Asn Leu Ser Pro 
            660                 665                 670         


Gly Ser Val Ile Ile Phe Arg Val Ser Leu Asp Pro His Ala Gln Val 
        675                 680                 685             


Ala Val Gly Ile Leu Arg Asn His Leu Thr Gln Phe Ser Pro His Phe 
    690                 695                 700                 


Lys Ser Gly Ser Leu Ala Val Asp Asn Ala Asp Pro Ile Leu Lys Ile 
705                 710                 715                 720 


Pro Phe Ala Ser Leu Ala Tyr Arg Leu Thr Leu Ala Glu Leu Asn Gln 
                725                 730                 735     


Ile Leu Tyr Arg Cys Glu Ser Glu Glu Lys Glu Asp Gly Gly Gly Cys 
            740                 745                 750         


Tyr Asp Ile Pro Asn Trp Ser Ala Leu Lys Tyr Ala Gly Leu Gln Gly 
        755                 760                 765             


Leu Met Ser Val Leu Ala Glu Ile Arg Pro Lys Asn Asp Leu Gly His 
    770                 775                 780                 


Pro Phe Cys Asn Asn Leu Arg Ser Gly Asp Trp Met Ile Asp Tyr Val 
785                 790                 795                 800 


Ser Asn Arg Leu Ile Ser Arg Ser Gly Thr Ile Ala Glu Val Gly Lys 
                805                 810                 815     


Trp Leu Gln Ala Met Phe Phe Tyr Leu Lys Gln Ile Pro Arg Tyr Leu 
            820                 825                 830         


Ile Pro Cys Tyr Phe Asp Ala Ile Leu Ile Gly Ala Tyr Thr Thr Leu 
        835                 840                 845             


Leu Asp Thr Ala Trp Lys Gln Met Ser Ser Phe Val Gln Asn Gly Ser 
    850                 855                 860                 


Thr Phe Val Lys His Leu Ser Leu Gly Ser Val Gln Leu Cys Gly Val 
865                 870                 875                 880 


Gly Lys Phe Pro Ser Leu Pro Ile Leu Ser Pro Ala Leu Met Asp Val 
                885                 890                 895     


Pro Tyr Arg Leu Asn Glu Ile Thr Lys Glu Lys Glu Gln Cys Cys Val 
            900                 905                 910         


Ser Leu Ala Ala Gly Leu Pro His Phe Ser Ser Gly Ile Phe Arg Cys 
        915                 920                 925             


Trp Gly Arg Asp Thr Phe Ile Ala Leu Arg Gly Ile Leu Leu Ile Thr 
    930                 935                 940                 


Gly Arg Tyr Val Glu Ala Arg Asn Ile Ile Leu Ala Phe Ala Gly Thr 
945                 950                 955                 960 


Leu Arg His Gly Leu Ile Pro Asn Leu Leu Gly Glu Gly Ile Tyr Ala 
                965                 970                 975     


Arg Tyr Asn Cys Arg Asp Ala Val Trp Trp Trp Leu Gln Cys Ile Gln 
            980                 985                 990         


Asp Tyr Cys Lys Met Val Pro Asn  Gly Leu Asp Ile Leu  Lys Cys Pro 
        995                 1000                 1005             


Val Ser  Arg Met Tyr Pro Thr  Asp Asp Ser Ala Pro  Leu Pro Ala 
    1010                 1015                 1020             


Gly Thr  Leu Asp Gln Pro Leu  Phe Glu Val Ile Gln  Glu Ala Met 
    1025                 1030                 1035             


Gln Lys  His Met Gln Gly Ile  Gln Phe Arg Glu Arg  Asn Ala Gly 
    1040                 1045                 1050             


Pro Gln  Ile Asp Arg Asn Met  Lys Asp Glu Gly Phe  Asn Ile Thr 
    1055                 1060                 1065             


Ala Gly  Val Asp Glu Glu Thr  Gly Phe Val Tyr Gly  Gly Asn Arg 
    1070                 1075                 1080             


Phe Asn  Cys Gly Thr Trp Met  Asp Lys Met Gly Glu  Ser Asp Arg 
    1085                 1090                 1095             


Ala Arg  Asn Arg Gly Ile Pro  Ala Thr Pro Arg Asp  Gly Ser Ala 
    1100                 1105                 1110             


Val Glu  Ile Val Gly Leu Ser  Lys Ser Ala Val Arg  Trp Leu Leu 
    1115                 1120                 1125             


Glu Leu  Ser Lys Lys Asn Ile  Phe Pro Tyr His Glu  Val Thr Val 
    1130                 1135                 1140             


Lys Arg  His Gly Lys Ala Ile  Lys Val Ser Tyr Asp  Glu Trp Asn 
    1145                 1150                 1155             


Arg Lys  Ile Gln Asp Asn Phe  Glu Lys Leu Phe His  Val Ser Glu 
    1160                 1165                 1170             


Asp Pro  Ser Asp Leu Asn Glu  Lys His Pro Asn Leu  Val His Lys 
    1175                 1180                 1185             


Arg Gly  Ile Tyr Lys Asp Ser  Tyr Gly Ala Ser Ser  Pro Trp Cys 
    1190                 1195                 1200             


Asp Tyr  Gln Leu Arg Pro Asn  Phe Thr Ile Ala Met  Val Val Ala 
    1205                 1210                 1215             


Pro Glu  Leu Phe Thr Thr Glu  Lys Ala Trp Lys Ala  Leu Glu Ile 
    1220                 1225                 1230             


Ala Glu  Lys Lys Leu Leu Gly  Pro Leu Gly Met Lys  Thr Leu Asp 
    1235                 1240                 1245             


Pro Asp  Asp Met Val Tyr Cys  Gly Ile Tyr Asp Asn  Ala Leu Asp 
    1250                 1255                 1260             


Asn Asp  Asn Tyr Asn Leu Ala  Lys Gly Phe Asn Tyr  His Gln Gly 
    1265                 1270                 1275             


Pro Glu  Trp Leu Trp Pro Ile  Gly Tyr Phe Leu Arg  Ala Lys Leu 
    1280                 1285                 1290             


Tyr Phe  Ser Arg Leu Met Gly  Pro Glu Thr Thr Ala  Lys Thr Ile 
    1295                 1300                 1305             


Val Leu  Val Lys Asn Val Leu  Ser Arg His Tyr Val  His Leu Glu 
    1310                 1315                 1320             


Arg Ser  Pro Trp Lys Gly Leu  Pro Glu Leu Thr Asn  Glu Asn Ala 
    1325                 1330                 1335             


Gln Tyr  Cys Pro Phe Ser Cys  Glu Thr Gln Ala Trp  Ser Ile Ala 
    1340                 1345                 1350             


Thr Ile  Leu Glu Thr Leu Tyr  Asp Leu 
    1355                 1360         


<210>  6
<211>  1339
<212>  PRT
<213>  artificial

<220>
<223>  D4 hGDE

<400>  6

Met Gly His Ser Lys Gln Ile Arg Ile Leu Leu Leu Asn Glu Met Glu 
1               5                   10                  15      


Lys Leu Glu Lys Thr Leu Phe Arg Leu Glu Gln Gly Tyr Glu Leu Gln 
            20                  25                  30          


Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val Tyr Thr 
        35                  40                  45              


Asn Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser 
    50                  55                  60                  


Leu Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp Lys Tyr 
65                  70                  75                  80  


Cys Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu 
                85                  90                  95      


Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile 
            100                 105                 110         


Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr 
        115                 120                 125             


Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu 
    130                 135                 140                 


Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe 
145                 150                 155                 160 


Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala 
                165                 170                 175     


Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr 
            180                 185                 190         


Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp 
        195                 200                 205             


Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn 
    210                 215                 220                 


Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn 
225                 230                 235                 240 


Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg 
                245                 250                 255     


Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro 
            260                 265                 270         


Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile 
        275                 280                 285             


Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val 
    290                 295                 300                 


Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu 
305                 310                 315                 320 


Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile 
                325                 330                 335     


Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile 
            340                 345                 350         


Ala Leu Thr Thr Phe Ile Pro His Asp Lys Gly Pro Ala Ala Ile Glu 
        355                 360                 365             


Glu Cys Cys Asn Trp Phe His Lys Arg Met Glu Glu Leu Asn Ser Glu 
    370                 375                 380                 


Lys His Arg Leu Ile Asn Tyr His Gln Glu Gln Ala Val Asn Cys Leu 
385                 390                 395                 400 


Leu Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His Gly Pro Lys Leu 
                405                 410                 415     


Gly Pro Val Thr Arg Lys His Pro Leu Val Thr Arg Tyr Phe Thr Phe 
            420                 425                 430         


Pro Phe Glu Glu Ile Asp Phe Ser Met Glu Glu Ser Met Ile His Leu 
        435                 440                 445             


Pro Asn Lys Ala Cys Phe Leu Met Ala His Asn Gly Trp Val Met Gly 
    450                 455                 460                 


Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu 
465                 470                 475                 480 


Arg Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly 
                485                 490                 495     


Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr 
            500                 505                 510         


Thr Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys 
        515                 520                 525             


His Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg 
    530                 535                 540                 


Asn Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser 
545                 550                 555                 560 


Glu Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu 
                565                 570                 575     


Ile Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu 
            580                 585                 590         


Val Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys 
        595                 600                 605             


Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile 
    610                 615                 620                 


Thr His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala 
625                 630                 635                 640 


Leu Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser 
                645                 650                 655     


Thr Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile Ser Val Val Ser 
            660                 665                 670         


Glu Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu Ala Leu Pro Ser Asn 
        675                 680                 685             


Thr Gly Glu Val Asn Phe Gln Ser Gly Ile Ile Ala Ala Arg Cys Ala 
    690                 695                 700                 


Ile Ser Lys Leu His Gln Glu Leu Gly Ala Lys Gly Phe Ile Gln Val 
705                 710                 715                 720 


Tyr Val Asp Gln Val Asp Glu Asp Ile Val Ala Val Thr Arg His Ser 
                725                 730                 735     


Pro Ser Ile His Gln Ser Val Val Ala Val Thr Arg Thr Ala Phe Arg 
            740                 745                 750         


Asn Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val Pro Gln Met Cys Ile 
        755                 760                 765             


Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg Thr Ile Glu Arg 
    770                 775                 780                 


Asn Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro 
785                 790                 795                 800 


Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu Asn Glu Ser Lys 
                805                 810                 815     


Ile Val Lys Gln Ala Gly Val Ala Thr Lys Gly Pro Asn Glu Tyr Ile 
            820                 825                 830         


Gln Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly Ser Val Ile Ile Phe 
        835                 840                 845             


Arg Val Ser Leu Asp Pro His Ala Gln Val Ala Val Gly Ile Leu Arg 
    850                 855                 860                 


Asn His Leu Thr Gln Phe Ser Pro His Phe Lys Ser Gly Ser Leu Ala 
865                 870                 875                 880 


Val Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro Phe Ala Ser Leu Pro 
                885                 890                 895     


His Phe Ser Ser Gly Ile Phe Arg Cys Trp Gly Arg Asp Thr Phe Ile 
            900                 905                 910         


Ala Leu Arg Gly Ile Leu Leu Ile Thr Gly Arg Tyr Val Glu Ala Arg 
        915                 920                 925             


Asn Ile Ile Leu Ala Phe Ala Gly Thr Leu Arg His Gly Leu Ile Pro 
    930                 935                 940                 


Asn Leu Leu Gly Glu Gly Ile Tyr Ala Arg Tyr Asn Cys Arg Asp Ala 
945                 950                 955                 960 


Val Trp Trp Trp Leu Gln Cys Ile Gln Asp Tyr Cys Lys Met Val Pro 
                965                 970                 975     


Asn Gly Leu Asp Ile Leu Lys Cys Pro Val Ser Arg Met Tyr Pro Thr 
            980                 985                 990         


Asp Asp Ser Ala Pro Leu Pro Ala  Gly Thr Leu Asp Gln  Pro Leu Phe 
        995                 1000                 1005             


Glu Val  Ile Gln Glu Ala Met  Gln Lys His Met Gln  Gly Ile Gln 
    1010                 1015                 1020             


Phe Arg  Glu Arg Asn Ala Gly  Pro Gln Ile Asp Arg  Asn Met Lys 
    1025                 1030                 1035             


Asp Glu  Gly Phe Asn Ile Thr  Ala Gly Val Asp Glu  Glu Thr Gly 
    1040                 1045                 1050             


Phe Val  Tyr Gly Gly Asn Arg  Phe Asn Cys Gly Thr  Trp Met Asp 
    1055                 1060                 1065             


Lys Met  Gly Glu Ser Asp Arg  Ala Arg Asn Arg Gly  Ile Pro Ala 
    1070                 1075                 1080             


Thr Pro  Arg Asp Gly Ser Ala  Val Glu Ile Val Gly  Leu Ser Lys 
    1085                 1090                 1095             


Ser Ala  Val Arg Trp Leu Leu  Glu Leu Ser Lys Lys  Asn Ile Phe 
    1100                 1105                 1110             


Pro Tyr  His Glu Val Thr Val  Lys Arg His Gly Lys  Ala Ile Lys 
    1115                 1120                 1125             


Val Ser  Tyr Asp Glu Trp Asn  Arg Lys Ile Gln Asp  Asn Phe Glu 
    1130                 1135                 1140             


Lys Leu  Phe His Val Ser Glu  Asp Pro Ser Asp Leu  Asn Glu Lys 
    1145                 1150                 1155             


His Pro  Asn Leu Val His Lys  Arg Gly Ile Tyr Lys  Asp Ser Tyr 
    1160                 1165                 1170             


Gly Ala  Ser Ser Pro Trp Cys  Asp Tyr Gln Leu Arg  Pro Asn Phe 
    1175                 1180                 1185             


Thr Ile  Ala Met Val Val Ala  Pro Glu Leu Phe Thr  Thr Glu Lys 
    1190                 1195                 1200             


Ala Trp  Lys Ala Leu Glu Ile  Ala Glu Lys Lys Leu  Leu Gly Pro 
    1205                 1210                 1215             


Leu Gly  Met Lys Thr Leu Asp  Pro Asp Asp Met Val  Tyr Cys Gly 
    1220                 1225                 1230             


Ile Tyr  Asp Asn Ala Leu Asp  Asn Asp Asn Tyr Asn  Leu Ala Lys 
    1235                 1240                 1245             


Gly Phe  Asn Tyr His Gln Gly  Pro Glu Trp Leu Trp  Pro Ile Gly 
    1250                 1255                 1260             


Tyr Phe  Leu Arg Ala Lys Leu  Tyr Phe Ser Arg Leu  Met Gly Pro 
    1265                 1270                 1275             


Glu Thr  Thr Ala Lys Thr Ile  Val Leu Val Lys Asn  Val Leu Ser 
    1280                 1285                 1290             


Arg His  Tyr Val His Leu Glu  Arg Ser Pro Trp Lys  Gly Leu Pro 
    1295                 1300                 1305             


Glu Leu  Thr Asn Glu Asn Ala  Gln Tyr Cys Pro Phe  Ser Cys Glu 
    1310                 1315                 1320             


Thr Gln  Ala Trp Ser Ile Ala  Thr Ile Leu Glu Thr  Leu Tyr Asp 
    1325                 1330                 1335             


Leu 
    


<210>  7
<211>  1313
<212>  PRT
<213>  artificial

<220>
<223>  D5 hGDE

<400>  7

Met Gly His Ser Lys Gln Ile Arg Ile Leu Leu Leu Asn Glu Met Glu 
1               5                   10                  15      


Lys Leu Glu Lys Thr Leu Phe Arg Leu Glu Gln Gly Tyr Glu Leu Gln 
            20                  25                  30          


Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val Tyr Thr 
        35                  40                  45              


Asn Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser 
    50                  55                  60                  


Leu Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp Lys Tyr 
65                  70                  75                  80  


Cys Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu 
                85                  90                  95      


Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile 
            100                 105                 110         


Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr 
        115                 120                 125             


Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu 
    130                 135                 140                 


Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe 
145                 150                 155                 160 


Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala 
                165                 170                 175     


Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr 
            180                 185                 190         


Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp 
        195                 200                 205             


Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Asn Arg 
    210                 215                 220                 


Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile Gln Asp 
225                 230                 235                 240 


Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile Ala Leu 
                245                 250                 255     


Thr Thr Phe Ile Pro Tyr Phe Thr Phe Pro Phe Glu Glu Ile Asp Phe 
            260                 265                 270         


Ser Met Glu Glu Ser Met Ile His Leu Pro Asn Lys Ala Cys Phe Leu 
        275                 280                 285             


Met Ala His Asn Gly Trp Val Met Gly Asp Asp Pro Leu Arg Asn Phe 
    290                 295                 300                 


Ala Glu Pro Gly Ser Glu Val Tyr Leu Arg Arg Glu Leu Ile Cys Trp 
305                 310                 315                 320 


Gly Asp Ser Val Lys Leu Arg Tyr Gly Asn Lys Pro Glu Asp Cys Pro 
                325                 330                 335     


Tyr Leu Trp Ala His Met Lys Lys Tyr Thr Glu Ile Thr Ala Thr Tyr 
            340                 345                 350         


Phe Gln Gly Val Arg Leu Asp Asn Cys His Ser Thr Pro Leu His Val 
        355                 360                 365             


Ala Glu Tyr Met Leu Asp Ala Ala Arg Asn Leu Gln Pro Asn Leu Tyr 
    370                 375                 380                 


Val Val Ala Glu Leu Phe Thr Gly Ser Glu Asp Leu Asp Asn Val Phe 
385                 390                 395                 400 


Val Thr Arg Leu Gly Ile Ser Ser Leu Ile Arg Glu Ala Met Ser Ala 
                405                 410                 415     


Tyr Asn Ser His Glu Glu Gly Arg Leu Val Tyr Arg Tyr Gly Gly Glu 
            420                 425                 430         


Pro Val Gly Ser Phe Val Gln Pro Cys Leu Arg Pro Leu Met Pro Ala 
        435                 440                 445             


Ile Ala His Ala Leu Phe Met Asp Ile Thr His Asp Asn Glu Cys Pro 
    450                 455                 460                 


Ile Val His Arg Ser Ala Tyr Asp Ala Leu Pro Ser Thr Thr Ile Val 
465                 470                 475                 480 


Ser Met Ala Cys Cys Ala Ser Gly Ser Thr Arg Gly Tyr Asp Glu Leu 
                485                 490                 495     


Val Pro His Gln Ile Tyr Val Asp Gln Val Asp Glu Asp Ile Val Ala 
            500                 505                 510         


Val Thr Arg His Ser Pro Ser Ile His Gln Ser Val Val Ala Val Thr 
        515                 520                 525             


Arg Thr Ala Phe Arg Asn Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val 
    530                 535                 540                 


Pro Gln Met Cys Ile Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala 
545                 550                 555                 560 


Arg Thr Ile Glu Arg Asn Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser 
                565                 570                 575     


Ile Asn Gly Thr Pro Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln 
            580                 585                 590         


Leu Asn Glu Ser Lys Ile Val Lys Gln Ala Gly Val Ala Thr Lys Gly 
        595                 600                 605             


Pro Asn Glu Tyr Ile Gln Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly 
    610                 615                 620                 


Ser Val Ile Ile Phe Arg Val Ser Leu Asp Pro His Ala Gln Val Ala 
625                 630                 635                 640 


Val Gly Ile Leu Arg Asn His Leu Thr Gln Phe Ser Pro His Phe Lys 
                645                 650                 655     


Ser Gly Ser Leu Ala Val Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro 
            660                 665                 670         


Phe Ala Ser Leu Ala Tyr Arg Leu Thr Leu Ala Glu Leu Asn Gln Ile 
        675                 680                 685             


Leu Tyr Arg Cys Glu Ser Glu Glu Lys Glu Asp Gly Gly Gly Cys Tyr 
    690                 695                 700                 


Asp Ile Pro Asn Trp Ser Ala Leu Lys Tyr Ala Gly Leu Gln Gly Leu 
705                 710                 715                 720 


Met Ser Val Leu Ala Glu Ile Arg Pro Lys Asn Asp Leu Gly His Pro 
                725                 730                 735     


Phe Cys Asn Asn Leu Arg Ser Gly Asp Trp Met Ile Asp Tyr Val Ser 
            740                 745                 750         


Asn Arg Leu Ile Ser Arg Ser Gly Thr Ile Ala Glu Val Gly Lys Trp 
        755                 760                 765             


Leu Gln Ala Met Phe Phe Tyr Leu Lys Gln Ile Pro Arg Tyr Leu Ile 
    770                 775                 780                 


Pro Cys Tyr Phe Asp Ala Ile Leu Ile Gly Ala Tyr Thr Thr Leu Leu 
785                 790                 795                 800 


Asp Thr Ala Trp Lys Gln Met Ser Ser Phe Val Gln Asn Gly Ser Thr 
                805                 810                 815     


Phe Val Lys His Leu Ser Leu Gly Ser Val Gln Leu Cys Gly Val Gly 
            820                 825                 830         


Lys Phe Pro Ser Leu Pro Ile Leu Ser Pro Ala Leu Met Asp Val Pro 
        835                 840                 845             


Tyr Arg Leu Asn Glu Ile Thr Lys Glu Lys Glu Gln Cys Cys Val Ser 
    850                 855                 860                 


Leu Ala Ala Gly Leu Pro His Phe Ser Ser Gly Ile Phe Arg Cys Trp 
865                 870                 875                 880 


Gly Arg Asp Thr Phe Ile Ala Leu Arg Gly Ile Leu Leu Ile Thr Gly 
                885                 890                 895     


Arg Tyr Val Glu Ala Arg Asn Ile Ile Leu Ala Phe Ala Gly Thr Leu 
            900                 905                 910         


Arg His Gly Leu Ile Pro Asn Leu Leu Gly Glu Gly Ile Tyr Ala Arg 
        915                 920                 925             


Tyr Asn Cys Arg Asp Ala Val Trp Trp Trp Leu Gln Cys Ile Gln Asp 
    930                 935                 940                 


Tyr Cys Lys Met Val Pro Asn Gly Leu Asp Ile Leu Lys Cys Pro Val 
945                 950                 955                 960 


Ser Arg Met Tyr Pro Thr Asp Asp Ser Ala Pro Leu Pro Ala Gly Thr 
                965                 970                 975     


Leu Asp Gln Pro Leu Phe Glu Val Ile Gln Glu Ala Met Gln Lys His 
            980                 985                 990         


Met Gln Gly Ile Gln Phe Arg Glu  Arg Asn Ala Gly Pro  Gln Ile Asp 
        995                 1000                 1005             


Arg Asn  Met Lys Asp Glu Gly  Phe Asn Ile Thr Ala  Gly Val Asp 
    1010                 1015                 1020             


Glu Glu  Thr Gly Phe Val Tyr  Gly Gly Asn Arg Phe  Asn Cys Gly 
    1025                 1030                 1035             


Thr Trp  Met Asp Lys Met Gly  Glu Ser Asp Arg Ala  Arg Asn Arg 
    1040                 1045                 1050             


Gly Ile  Pro Ala Thr Pro Arg  Asp Gly Ser Ala Val  Glu Ile Val 
    1055                 1060                 1065             


Gly Leu  Ser Lys Ser Ala Val  Arg Trp Leu Leu Glu  Leu Ser Lys 
    1070                 1075                 1080             


Lys Asn  Ile Phe Pro Tyr His  Glu Val Thr Val Lys  Arg His Gly 
    1085                 1090                 1095             


Lys Ala  Ile Lys Val Ser Tyr  Asp Glu Trp Asn Arg  Lys Ile Gln 
    1100                 1105                 1110             


Asp Asn  Phe Glu Lys Leu Phe  His Val Ser Glu Asp  Pro Ser Asp 
    1115                 1120                 1125             


Leu Asn  Glu Lys His Pro Asn  Leu Val His Lys Arg  Gly Ile Tyr 
    1130                 1135                 1140             


Lys Asp  Ser Tyr Gly Ala Ser  Ser Pro Trp Cys Asp  Tyr Gln Leu 
    1145                 1150                 1155             


Arg Pro  Asn Phe Thr Ile Ala  Met Val Val Ala Pro  Glu Leu Phe 
    1160                 1165                 1170             


Thr Thr  Glu Lys Ala Trp Lys  Ala Leu Glu Ile Ala  Glu Lys Lys 
    1175                 1180                 1185             


Leu Leu  Gly Pro Leu Gly Met  Lys Thr Leu Asp Pro  Asp Asp Met 
    1190                 1195                 1200             


Val Tyr  Cys Gly Ile Tyr Asp  Asn Ala Leu Asp Asn  Asp Asn Tyr 
    1205                 1210                 1215             


Asn Leu  Ala Lys Gly Phe Asn  Tyr His Gln Gly Pro  Glu Trp Leu 
    1220                 1225                 1230             


Trp Pro  Ile Gly Tyr Phe Leu  Arg Ala Lys Leu Tyr  Phe Ser Arg 
    1235                 1240                 1245             


Leu Met  Gly Pro Glu Thr Thr  Ala Lys Thr Ile Val  Leu Val Lys 
    1250                 1255                 1260             


Asn Val  Leu Ser Arg His Tyr  Val His Leu Glu Arg  Ser Pro Trp 
    1265                 1270                 1275             


Lys Gly  Leu Pro Glu Leu Thr  Asn Glu Asn Ala Gln  Tyr Cys Pro 
    1280                 1285                 1290             


Phe Ser  Cys Glu Thr Gln Ala  Trp Ser Ile Ala Thr  Ile Leu Glu 
    1295                 1300                 1305             


Thr Leu  Tyr Asp Leu 
    1310             


<210>  8
<211>  1252
<212>  PRT
<213>  artificial

<220>
<223>  D6 hGDE

<400>  8

Met Asn Ser Ile Arg Lys Ile Ile Trp Glu Asp Ile Phe Pro Lys Leu 
1               5                   10                  15      


Lys Leu Trp Glu Phe Phe Gln Val Asp Val Asn Lys Ala Val Glu Gln 
            20                  25                  30          


Phe Arg Arg Leu Leu Thr Gln Glu Asn Arg Arg Val Thr Lys Ser Asp 
        35                  40                  45              


Pro Asn Gln His Leu Thr Ile Ile Gln Asp Pro Glu Tyr Arg Arg Phe 
    50                  55                  60                  


Gly Cys Thr Val Asp Met Asn Ile Ala Leu Thr Thr Phe Ile Pro His 
65                  70                  75                  80  


Asp Lys Gly Pro Ala Ala Ile Glu Glu Cys Cys Asn Trp Phe His Lys 
                85                  90                  95      


Arg Met Glu Glu Leu Asn Ser Glu Lys His Arg Leu Ile Asn Tyr His 
            100                 105                 110         


Gln Glu Gln Ala Val Asn Cys Leu Leu Gly Asn Val Phe Tyr Glu Arg 
        115                 120                 125             


Leu Ala Gly His Gly Pro Lys Leu Gly Pro Val Thr Arg Lys His Pro 
    130                 135                 140                 


Leu Val Thr Arg Tyr Phe Thr Phe Pro Phe Glu Glu Ile Asp Phe Ser 
145                 150                 155                 160 


Met Glu Glu Ser Met Ile His Leu Pro Asn Lys Ala Cys Phe Leu Met 
                165                 170                 175     


Ala His Asn Gly Trp Val Met Gly Asp Asp Pro Leu Arg Asn Phe Ala 
            180                 185                 190         


Glu Pro Gly Ser Glu Val Tyr Leu Arg Arg Glu Leu Ile Cys Trp Gly 
        195                 200                 205             


Asp Ser Val Lys Leu Arg Tyr Gly Asn Lys Pro Glu Asp Cys Pro Tyr 
    210                 215                 220                 


Leu Trp Ala His Met Lys Lys Tyr Thr Glu Ile Thr Ala Thr Tyr Phe 
225                 230                 235                 240 


Gln Gly Val Arg Leu Asp Asn Cys His Ser Thr Pro Leu His Val Ala 
                245                 250                 255     


Glu Tyr Met Leu Asp Ala Ala Arg Asn Leu Gln Pro Asn Leu Tyr Val 
            260                 265                 270         


Val Ala Glu Leu Phe Thr Gly Ser Glu Asp Leu Asp Asn Val Phe Val 
        275                 280                 285             


Thr Arg Leu Gly Ile Ser Ser Leu Ile Arg Glu Ala Met Ser Ala Tyr 
    290                 295                 300                 


Asn Ser His Glu Glu Gly Arg Leu Val Tyr Arg Tyr Gly Gly Glu Pro 
305                 310                 315                 320 


Val Gly Ser Phe Val Gln Pro Cys Leu Arg Pro Leu Met Pro Ala Ile 
                325                 330                 335     


Ala His Ala Leu Phe Met Asp Ile Thr His Asp Asn Glu Cys Pro Ile 
            340                 345                 350         


Val His Arg Ser Ala Tyr Asp Ala Leu Pro Ser Thr Thr Ile Val Ser 
        355                 360                 365             


Met Ala Cys Cys Ala Ser Gly Ser Thr Arg Gly Tyr Asp Glu Leu Val 
    370                 375                 380                 


Pro His Gln Ile Ser Val Val Ser Glu Glu Arg Phe Tyr Thr Lys Trp 
385                 390                 395                 400 


Asn Pro Glu Ala Leu Pro Ser Asn Thr Gly Glu Val Asn Phe Gln Ser 
                405                 410                 415     


Gly Ile Ile Ala Ala Arg Cys Ala Ile Ser Lys Leu His Gln Glu Leu 
            420                 425                 430         


Gly Ala Lys Gly Phe Ile Gln Val Tyr Val Asp Gln Val Asp Glu Asp 
        435                 440                 445             


Ile Val Ala Val Thr Arg His Ser Pro Ser Ile His Gln Ser Val Val 
    450                 455                 460                 


Ala Val Thr Arg Thr Ala Phe Arg Asn Pro Lys Thr Ser Phe Tyr Ser 
465                 470                 475                 480 


Lys Glu Val Pro Gln Met Cys Ile Pro Gly Lys Ile Glu Glu Val Val 
                485                 490                 495     


Leu Glu Ala Arg Thr Ile Glu Arg Asn Thr Lys Pro Tyr Arg Lys Asp 
            500                 505                 510         


Glu Asn Ser Ile Asn Gly Thr Pro Asp Ile Thr Val Glu Ile Arg Glu 
        515                 520                 525             


His Ile Gln Leu Asn Glu Ser Lys Ile Val Lys Gln Ala Gly Val Ala 
    530                 535                 540                 


Thr Lys Gly Pro Asn Glu Tyr Ile Gln Glu Ile Glu Phe Glu Asn Leu 
545                 550                 555                 560 


Ser Pro Gly Ser Val Ile Ile Phe Arg Val Ser Leu Asp Pro His Ala 
                565                 570                 575     


Gln Val Ala Val Gly Ile Leu Arg Asn His Leu Thr Gln Phe Ser Pro 
            580                 585                 590         


His Phe Lys Ser Gly Ser Leu Ala Val Asp Asn Ala Asp Pro Ile Leu 
        595                 600                 605             


Lys Ile Pro Phe Ala Ser Leu Ala Tyr Arg Leu Thr Leu Ala Glu Leu 
    610                 615                 620                 


Asn Gln Ile Leu Tyr Arg Cys Glu Ser Glu Glu Lys Glu Asp Gly Gly 
625                 630                 635                 640 


Gly Cys Tyr Asp Ile Pro Asn Trp Ser Ala Leu Lys Tyr Ala Gly Leu 
                645                 650                 655     


Gln Gly Leu Met Ser Val Leu Ala Glu Ile Arg Pro Lys Asn Asp Leu 
            660                 665                 670         


Gly His Pro Phe Cys Asn Asn Leu Arg Ser Gly Asp Trp Met Ile Asp 
        675                 680                 685             


Tyr Val Ser Asn Arg Leu Ile Ser Arg Ser Gly Thr Ile Ala Glu Val 
    690                 695                 700                 


Gly Lys Trp Leu Gln Ala Met Phe Phe Tyr Leu Lys Gln Ile Pro Arg 
705                 710                 715                 720 


Tyr Leu Ile Pro Cys Tyr Phe Asp Ala Ile Leu Ile Gly Ala Tyr Thr 
                725                 730                 735     


Thr Leu Leu Asp Thr Ala Trp Lys Gln Met Ser Ser Phe Val Gln Asn 
            740                 745                 750         


Gly Ser Thr Phe Val Lys His Leu Ser Leu Gly Ser Val Gln Leu Cys 
        755                 760                 765             


Gly Val Gly Lys Phe Pro Ser Leu Pro Ile Leu Ser Pro Ala Leu Met 
    770                 775                 780                 


Asp Val Pro Tyr Arg Leu Asn Glu Ile Thr Lys Glu Lys Glu Gln Cys 
785                 790                 795                 800 


Cys Val Ser Leu Ala Ala Gly Leu Pro His Phe Ser Ser Gly Ile Phe 
                805                 810                 815     


Arg Cys Trp Gly Arg Asp Thr Phe Ile Ala Leu Arg Gly Ile Leu Leu 
            820                 825                 830         


Ile Thr Gly Arg Tyr Val Glu Ala Arg Asn Ile Ile Leu Ala Phe Ala 
        835                 840                 845             


Gly Thr Leu Arg His Gly Leu Ile Pro Asn Leu Leu Gly Glu Gly Ile 
    850                 855                 860                 


Tyr Ala Arg Tyr Asn Cys Arg Asp Ala Val Trp Trp Trp Leu Gln Cys 
865                 870                 875                 880 


Ile Gln Asp Tyr Cys Lys Met Val Pro Asn Gly Leu Asp Ile Leu Lys 
                885                 890                 895     


Cys Pro Val Ser Arg Met Tyr Pro Thr Asp Asp Ser Ala Pro Leu Pro 
            900                 905                 910         


Ala Gly Thr Leu Asp Gln Pro Leu Phe Glu Val Ile Gln Glu Ala Met 
        915                 920                 925             


Gln Lys His Met Gln Gly Ile Gln Phe Arg Glu Arg Asn Ala Gly Pro 
    930                 935                 940                 


Gln Ile Asp Arg Asn Met Lys Asp Glu Gly Phe Asn Ile Thr Ala Gly 
945                 950                 955                 960 


Val Asp Glu Glu Thr Gly Phe Val Tyr Gly Gly Asn Arg Phe Asn Cys 
                965                 970                 975     


Gly Thr Trp Met Asp Lys Met Gly Glu Ser Asp Arg Ala Arg Asn Arg 
            980                 985                 990         


Gly Ile Pro Ala Thr Pro Arg Asp  Gly Ser Ala Val Glu  Ile Val Gly 
        995                 1000                 1005             


Leu Ser  Lys Ser Ala Val Arg  Trp Leu Leu Glu Leu  Ser Lys Lys 
    1010                 1015                 1020             


Asn Ile  Phe Pro Tyr His Glu  Val Thr Val Lys Arg  His Gly Lys 
    1025                 1030                 1035             


Ala Ile  Lys Val Ser Tyr Asp  Glu Trp Asn Arg Lys  Ile Gln Asp 
    1040                 1045                 1050             


Asn Phe  Glu Lys Leu Phe His  Val Ser Glu Asp Pro  Ser Asp Leu 
    1055                 1060                 1065             


Asn Glu  Lys His Pro Asn Leu  Val His Lys Arg Gly  Ile Tyr Lys 
    1070                 1075                 1080             


Asp Ser  Tyr Gly Ala Ser Ser  Pro Trp Cys Asp Tyr  Gln Leu Arg 
    1085                 1090                 1095             


Pro Asn  Phe Thr Ile Ala Met  Val Val Ala Pro Glu  Leu Phe Thr 
    1100                 1105                 1110             


Thr Glu  Lys Ala Trp Lys Ala  Leu Glu Ile Ala Glu  Lys Lys Leu 
    1115                 1120                 1125             


Leu Gly  Pro Leu Gly Met Lys  Thr Leu Asp Pro Asp  Asp Met Val 
    1130                 1135                 1140             


Tyr Cys  Gly Ile Tyr Asp Asn  Ala Leu Asp Asn Asp  Asn Tyr Asn 
    1145                 1150                 1155             


Leu Ala  Lys Gly Phe Asn Tyr  His Gln Gly Pro Glu  Trp Leu Trp 
    1160                 1165                 1170             


Pro Ile  Gly Tyr Phe Leu Arg  Ala Lys Leu Tyr Phe  Ser Arg Leu 
    1175                 1180                 1185             


Met Gly  Pro Glu Thr Thr Ala  Lys Thr Ile Val Leu  Val Lys Asn 
    1190                 1195                 1200             


Val Leu  Ser Arg His Tyr Val  His Leu Glu Arg Ser  Pro Trp Lys 
    1205                 1210                 1215             


Gly Leu  Pro Glu Leu Thr Asn  Glu Asn Ala Gln Tyr  Cys Pro Phe 
    1220                 1225                 1230             


Ser Cys  Glu Thr Gln Ala Trp  Ser Ile Ala Thr Ile  Leu Glu Thr 
    1235                 1240                 1245             


Leu Tyr  Asp Leu 
    1250         


<210>  9
<211>  1108
<212>  PRT
<213>  artificial

<220>
<223>  D7 hGDE

<400>  9

Met Val Thr Arg Tyr Phe Thr Phe Pro Phe Glu Glu Ile Asp Phe Ser 
1               5                   10                  15      


Met Glu Glu Ser Met Ile His Leu Pro Asn Lys Ala Cys Phe Leu Met 
            20                  25                  30          


Ala His Asn Gly Trp Val Met Gly Asp Asp Pro Leu Arg Asn Phe Ala 
        35                  40                  45              


Glu Pro Gly Ser Glu Val Tyr Leu Arg Arg Glu Leu Ile Cys Trp Gly 
    50                  55                  60                  


Asp Ser Val Lys Leu Arg Tyr Gly Asn Lys Pro Glu Asp Cys Pro Tyr 
65                  70                  75                  80  


Leu Trp Ala His Met Lys Lys Tyr Thr Glu Ile Thr Ala Thr Tyr Phe 
                85                  90                  95      


Gln Gly Val Arg Leu Asp Asn Cys His Ser Thr Pro Leu His Val Ala 
            100                 105                 110         


Glu Tyr Met Leu Asp Ala Ala Arg Asn Leu Gln Pro Asn Leu Tyr Val 
        115                 120                 125             


Val Ala Glu Leu Phe Thr Gly Ser Glu Asp Leu Asp Asn Val Phe Val 
    130                 135                 140                 


Thr Arg Leu Gly Ile Ser Ser Leu Ile Arg Glu Ala Met Ser Ala Tyr 
145                 150                 155                 160 


Asn Ser His Glu Glu Gly Arg Leu Val Tyr Arg Tyr Gly Gly Glu Pro 
                165                 170                 175     


Val Gly Ser Phe Val Gln Pro Cys Leu Arg Pro Leu Met Pro Ala Ile 
            180                 185                 190         


Ala His Ala Leu Phe Met Asp Ile Thr His Asp Asn Glu Cys Pro Ile 
        195                 200                 205             


Val His Arg Ser Ala Tyr Asp Ala Leu Pro Ser Thr Thr Ile Val Ser 
    210                 215                 220                 


Met Ala Cys Cys Ala Ser Gly Ser Thr Arg Gly Tyr Asp Glu Leu Val 
225                 230                 235                 240 


Pro His Gln Ile Ser Val Val Ser Glu Glu Arg Phe Tyr Thr Lys Trp 
                245                 250                 255     


Asn Pro Glu Ala Leu Pro Ser Asn Thr Gly Glu Val Asn Phe Gln Ser 
            260                 265                 270         


Gly Ile Ile Ala Ala Arg Cys Ala Ile Ser Lys Leu His Gln Glu Leu 
        275                 280                 285             


Gly Ala Lys Gly Phe Ile Gln Val Tyr Val Asp Gln Val Asp Glu Asp 
    290                 295                 300                 


Ile Val Ala Val Thr Arg His Ser Pro Ser Ile His Gln Ser Val Val 
305                 310                 315                 320 


Ala Val Thr Arg Thr Ala Phe Arg Asn Pro Lys Thr Ser Phe Tyr Ser 
                325                 330                 335     


Lys Glu Val Pro Gln Met Cys Ile Pro Gly Lys Ile Glu Glu Val Val 
            340                 345                 350         


Leu Glu Ala Arg Thr Ile Glu Arg Asn Thr Lys Pro Tyr Arg Lys Asp 
        355                 360                 365             


Glu Asn Ser Ile Asn Gly Thr Pro Asp Ile Thr Val Glu Ile Arg Glu 
    370                 375                 380                 


His Ile Gln Leu Asn Glu Ser Lys Ile Val Lys Gln Ala Gly Val Ala 
385                 390                 395                 400 


Thr Lys Gly Pro Asn Glu Tyr Ile Gln Glu Ile Glu Phe Glu Asn Leu 
                405                 410                 415     


Ser Pro Gly Ser Val Ile Ile Phe Arg Val Ser Leu Asp Pro His Ala 
            420                 425                 430         


Gln Val Ala Val Gly Ile Leu Arg Asn His Leu Thr Gln Phe Ser Pro 
        435                 440                 445             


His Phe Lys Ser Gly Ser Leu Ala Val Asp Asn Ala Asp Pro Ile Leu 
    450                 455                 460                 


Lys Ile Pro Phe Ala Ser Leu Ala Tyr Arg Leu Thr Leu Ala Glu Leu 
465                 470                 475                 480 


Asn Gln Ile Leu Tyr Arg Cys Glu Ser Glu Glu Lys Glu Asp Gly Gly 
                485                 490                 495     


Gly Cys Tyr Asp Ile Pro Asn Trp Ser Ala Leu Lys Tyr Ala Gly Leu 
            500                 505                 510         


Gln Gly Leu Met Ser Val Leu Ala Glu Ile Arg Pro Lys Asn Asp Leu 
        515                 520                 525             


Gly His Pro Phe Cys Asn Asn Leu Arg Ser Gly Asp Trp Met Ile Asp 
    530                 535                 540                 


Tyr Val Ser Asn Arg Leu Ile Ser Arg Ser Gly Thr Ile Ala Glu Val 
545                 550                 555                 560 


Gly Lys Trp Leu Gln Ala Met Phe Phe Tyr Leu Lys Gln Ile Pro Arg 
                565                 570                 575     


Tyr Leu Ile Pro Cys Tyr Phe Asp Ala Ile Leu Ile Gly Ala Tyr Thr 
            580                 585                 590         


Thr Leu Leu Asp Thr Ala Trp Lys Gln Met Ser Ser Phe Val Gln Asn 
        595                 600                 605             


Gly Ser Thr Phe Val Lys His Leu Ser Leu Gly Ser Val Gln Leu Cys 
    610                 615                 620                 


Gly Val Gly Lys Phe Pro Ser Leu Pro Ile Leu Ser Pro Ala Leu Met 
625                 630                 635                 640 


Asp Val Pro Tyr Arg Leu Asn Glu Ile Thr Lys Glu Lys Glu Gln Cys 
                645                 650                 655     


Cys Val Ser Leu Ala Ala Gly Leu Pro His Phe Ser Ser Gly Ile Phe 
            660                 665                 670         


Arg Cys Trp Gly Arg Asp Thr Phe Ile Ala Leu Arg Gly Ile Leu Leu 
        675                 680                 685             


Ile Thr Gly Arg Tyr Val Glu Ala Arg Asn Ile Ile Leu Ala Phe Ala 
    690                 695                 700                 


Gly Thr Leu Arg His Gly Leu Ile Pro Asn Leu Leu Gly Glu Gly Ile 
705                 710                 715                 720 


Tyr Ala Arg Tyr Asn Cys Arg Asp Ala Val Trp Trp Trp Leu Gln Cys 
                725                 730                 735     


Ile Gln Asp Tyr Cys Lys Met Val Pro Asn Gly Leu Asp Ile Leu Lys 
            740                 745                 750         


Cys Pro Val Ser Arg Met Tyr Pro Thr Asp Asp Ser Ala Pro Leu Pro 
        755                 760                 765             


Ala Gly Thr Leu Asp Gln Pro Leu Phe Glu Val Ile Gln Glu Ala Met 
    770                 775                 780                 


Gln Lys His Met Gln Gly Ile Gln Phe Arg Glu Arg Asn Ala Gly Pro 
785                 790                 795                 800 


Gln Ile Asp Arg Asn Met Lys Asp Glu Gly Phe Asn Ile Thr Ala Gly 
                805                 810                 815     


Val Asp Glu Glu Thr Gly Phe Val Tyr Gly Gly Asn Arg Phe Asn Cys 
            820                 825                 830         


Gly Thr Trp Met Asp Lys Met Gly Glu Ser Asp Arg Ala Arg Asn Arg 
        835                 840                 845             


Gly Ile Pro Ala Thr Pro Arg Asp Gly Ser Ala Val Glu Ile Val Gly 
    850                 855                 860                 


Leu Ser Lys Ser Ala Val Arg Trp Leu Leu Glu Leu Ser Lys Lys Asn 
865                 870                 875                 880 


Ile Phe Pro Tyr His Glu Val Thr Val Lys Arg His Gly Lys Ala Ile 
                885                 890                 895     


Lys Val Ser Tyr Asp Glu Trp Asn Arg Lys Ile Gln Asp Asn Phe Glu 
            900                 905                 910         


Lys Leu Phe His Val Ser Glu Asp Pro Ser Asp Leu Asn Glu Lys His 
        915                 920                 925             


Pro Asn Leu Val His Lys Arg Gly Ile Tyr Lys Asp Ser Tyr Gly Ala 
    930                 935                 940                 


Ser Ser Pro Trp Cys Asp Tyr Gln Leu Arg Pro Asn Phe Thr Ile Ala 
945                 950                 955                 960 


Met Val Val Ala Pro Glu Leu Phe Thr Thr Glu Lys Ala Trp Lys Ala 
                965                 970                 975     


Leu Glu Ile Ala Glu Lys Lys Leu Leu Gly Pro Leu Gly Met Lys Thr 
            980                 985                 990         


Leu Asp Pro Asp Asp Met Val Tyr  Cys Gly Ile Tyr Asp  Asn Ala Leu 
        995                 1000                 1005             


Asp Asn  Asp Asn Tyr Asn Leu  Ala Lys Gly Phe Asn  Tyr His Gln 
    1010                 1015                 1020             


Gly Pro  Glu Trp Leu Trp Pro  Ile Gly Tyr Phe Leu  Arg Ala Lys 
    1025                 1030                 1035             


Leu Tyr  Phe Ser Arg Leu Met  Gly Pro Glu Thr Thr  Ala Lys Thr 
    1040                 1045                 1050             


Ile Val  Leu Val Lys Asn Val  Leu Ser Arg His Tyr  Val His Leu 
    1055                 1060                 1065             


Glu Arg  Ser Pro Trp Lys Gly  Leu Pro Glu Leu Thr  Asn Glu Asn 
    1070                 1075                 1080             


Ala Gln  Tyr Cys Pro Phe Ser  Cys Glu Thr Gln Ala  Trp Ser Ile 
    1085                 1090                 1095             


Ala Thr  Ile Leu Glu Thr Leu  Tyr Asp Leu 
    1100                 1105             


<210>  10
<211>  1303
<212>  PRT
<213>  artificial

<220>
<223>  D8 hGDE

<400>  10

Met His Pro Glu Cys Ala Tyr Asn Leu Val Asn Ser Pro His Leu Lys 
1               5                   10                  15      


Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg Phe Ser Cys Asp Val 
            20                  25                  30          


Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro Ala Leu Ile Glu Asn 
        35                  40                  45              


Asp His His Met Asn Ser Ile Arg Lys Ile Ile Trp Glu Asp Ile Phe 
    50                  55                  60                  


Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val Asp Val Asn Lys Ala 
65                  70                  75                  80  


Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu Asn Arg Arg Val Thr 
                85                  90                  95      


Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile Gln Asp Pro Glu Tyr 
            100                 105                 110         


Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile Ala Leu Thr Thr Phe 
        115                 120                 125             


Ile Pro His Asp Lys Gly Pro Ala Ala Ile Glu Glu Cys Cys Asn Trp 
    130                 135                 140                 


Phe His Lys Arg Met Glu Glu Leu Asn Ser Glu Lys His Arg Leu Ile 
145                 150                 155                 160 


Asn Tyr His Gln Glu Gln Ala Val Asn Cys Leu Leu Gly Asn Val Phe 
                165                 170                 175     


Tyr Glu Arg Leu Ala Gly His Gly Pro Lys Leu Gly Pro Val Thr Arg 
            180                 185                 190         


Lys His Pro Leu Val Thr Arg Tyr Phe Thr Phe Pro Phe Glu Glu Ile 
        195                 200                 205             


Asp Phe Ser Met Glu Glu Ser Met Ile His Leu Pro Asn Lys Ala Cys 
    210                 215                 220                 


Phe Leu Met Ala His Asn Gly Trp Val Met Gly Asp Asp Pro Leu Arg 
225                 230                 235                 240 


Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu Arg Arg Glu Leu Ile 
                245                 250                 255     


Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly Asn Lys Pro Glu Asp 
            260                 265                 270         


Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr Thr Glu Ile Thr Ala 
        275                 280                 285             


Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys His Ser Thr Pro Leu 
    290                 295                 300                 


His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg Asn Leu Gln Pro Asn 
305                 310                 315                 320 


Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser Glu Asp Leu Asp Asn 
                325                 330                 335     


Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu Ile Arg Glu Ala Met 
            340                 345                 350         


Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu Val Tyr Arg Tyr Gly 
        355                 360                 365             


Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys Leu Arg Pro Leu Met 
    370                 375                 380                 


Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile Thr His Asp Asn Glu 
385                 390                 395                 400 


Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala Leu Pro Ser Thr Thr 
                405                 410                 415     


Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser Thr Arg Gly Tyr Asp 
            420                 425                 430         


Glu Leu Val Pro His Gln Ile Ser Val Val Ser Glu Glu Arg Phe Tyr 
        435                 440                 445             


Thr Lys Trp Asn Pro Glu Ala Leu Pro Ser Asn Thr Gly Glu Val Asn 
    450                 455                 460                 


Phe Gln Ser Gly Ile Ile Ala Ala Arg Cys Ala Ile Ser Lys Leu His 
465                 470                 475                 480 


Gln Glu Leu Gly Ala Lys Gly Phe Ile Gln Val Tyr Val Asp Gln Val 
                485                 490                 495     


Asp Glu Asp Ile Val Ala Val Thr Arg His Ser Pro Ser Ile His Gln 
            500                 505                 510         


Ser Val Val Ala Val Thr Arg Thr Ala Phe Arg Asn Pro Lys Thr Ser 
        515                 520                 525             


Phe Tyr Ser Lys Glu Val Pro Gln Met Cys Ile Pro Gly Lys Ile Glu 
    530                 535                 540                 


Glu Val Val Leu Glu Ala Arg Thr Ile Glu Arg Asn Thr Lys Pro Tyr 
545                 550                 555                 560 


Arg Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro Asp Ile Thr Val Glu 
                565                 570                 575     


Ile Arg Glu His Ile Gln Leu Asn Glu Ser Lys Ile Val Lys Gln Ala 
            580                 585                 590         


Gly Val Ala Thr Lys Gly Pro Asn Glu Tyr Ile Gln Glu Ile Glu Phe 
        595                 600                 605             


Glu Asn Leu Ser Pro Gly Ser Val Ile Ile Phe Arg Val Ser Leu Asp 
    610                 615                 620                 


Pro His Ala Gln Val Ala Val Gly Ile Leu Arg Asn His Leu Thr Gln 
625                 630                 635                 640 


Phe Ser Pro His Phe Lys Ser Gly Ser Leu Ala Val Asp Asn Ala Asp 
                645                 650                 655     


Pro Ile Leu Lys Ile Pro Phe Ala Ser Leu Ala Tyr Arg Leu Thr Leu 
            660                 665                 670         


Ala Glu Leu Asn Gln Ile Leu Tyr Arg Cys Glu Ser Glu Glu Lys Glu 
        675                 680                 685             


Asp Gly Gly Gly Cys Tyr Asp Ile Pro Asn Trp Ser Ala Leu Lys Tyr 
    690                 695                 700                 


Ala Gly Leu Gln Gly Leu Met Ser Val Leu Ala Glu Ile Arg Pro Lys 
705                 710                 715                 720 


Asn Asp Leu Gly His Pro Phe Cys Asn Asn Leu Arg Ser Gly Asp Trp 
                725                 730                 735     


Met Ile Asp Tyr Val Ser Asn Arg Leu Ile Ser Arg Ser Gly Thr Ile 
            740                 745                 750         


Ala Glu Val Gly Lys Trp Leu Gln Ala Met Phe Phe Tyr Leu Lys Gln 
        755                 760                 765             


Ile Pro Arg Tyr Leu Ile Pro Cys Tyr Phe Asp Ala Ile Leu Ile Gly 
    770                 775                 780                 


Ala Tyr Thr Thr Leu Leu Asp Thr Ala Trp Lys Gln Met Ser Ser Phe 
785                 790                 795                 800 


Val Gln Asn Gly Ser Thr Phe Val Lys His Leu Ser Leu Gly Ser Val 
                805                 810                 815     


Gln Leu Cys Gly Val Gly Lys Phe Pro Ser Leu Pro Ile Leu Ser Pro 
            820                 825                 830         


Ala Leu Met Asp Val Pro Tyr Arg Leu Asn Glu Ile Thr Lys Glu Lys 
        835                 840                 845             


Glu Gln Cys Cys Val Ser Leu Ala Ala Gly Leu Pro His Phe Ser Ser 
    850                 855                 860                 


Gly Ile Phe Arg Cys Trp Gly Arg Asp Thr Phe Ile Ala Leu Arg Gly 
865                 870                 875                 880 


Ile Leu Leu Ile Thr Gly Arg Tyr Val Glu Ala Arg Asn Ile Ile Leu 
                885                 890                 895     


Ala Phe Ala Gly Thr Leu Arg His Gly Leu Ile Pro Asn Leu Leu Gly 
            900                 905                 910         


Glu Gly Ile Tyr Ala Arg Tyr Asn Cys Arg Asp Ala Val Trp Trp Trp 
        915                 920                 925             


Leu Gln Cys Ile Gln Asp Tyr Cys Lys Met Val Pro Asn Gly Leu Asp 
    930                 935                 940                 


Ile Leu Lys Cys Pro Val Ser Arg Met Tyr Pro Thr Asp Asp Ser Ala 
945                 950                 955                 960 


Pro Leu Pro Ala Gly Thr Leu Asp Gln Pro Leu Phe Glu Val Ile Gln 
                965                 970                 975     


Glu Ala Met Gln Lys His Met Gln Gly Ile Gln Phe Arg Glu Arg Asn 
            980                 985                 990         


Ala Gly Pro Gln Ile Asp Arg Asn  Met Lys Asp Glu Gly  Phe Asn Ile 
        995                 1000                 1005             


Thr Ala  Gly Val Asp Glu Glu  Thr Gly Phe Val Tyr  Gly Gly Asn 
    1010                 1015                 1020             


Arg Phe  Asn Cys Gly Thr Trp  Met Asp Lys Met Gly  Glu Ser Asp 
    1025                 1030                 1035             


Arg Ala  Arg Asn Arg Gly Ile  Pro Ala Thr Pro Arg  Asp Gly Ser 
    1040                 1045                 1050             


Ala Val  Glu Ile Val Gly Leu  Ser Lys Ser Ala Val  Arg Trp Leu 
    1055                 1060                 1065             


Leu Glu  Leu Ser Lys Lys Asn  Ile Phe Pro Tyr His  Glu Val Thr 
    1070                 1075                 1080             


Val Lys  Arg His Gly Lys Ala  Ile Lys Val Ser Tyr  Asp Glu Trp 
    1085                 1090                 1095             


Asn Arg  Lys Ile Gln Asp Asn  Phe Glu Lys Leu Phe  His Val Ser 
    1100                 1105                 1110             


Glu Asp  Pro Ser Asp Leu Asn  Glu Lys His Pro Asn  Leu Val His 
    1115                 1120                 1125             


Lys Arg  Gly Ile Tyr Lys Asp  Ser Tyr Gly Ala Ser  Ser Pro Trp 
    1130                 1135                 1140             


Cys Asp  Tyr Gln Leu Arg Pro  Asn Phe Thr Ile Ala  Met Val Val 
    1145                 1150                 1155             


Ala Pro  Glu Leu Phe Thr Thr  Glu Lys Ala Trp Lys  Ala Leu Glu 
    1160                 1165                 1170             


Ile Ala  Glu Lys Lys Leu Leu  Gly Pro Leu Gly Met  Lys Thr Leu 
    1175                 1180                 1185             


Asp Pro  Asp Asp Met Val Tyr  Cys Gly Ile Tyr Asp  Asn Ala Leu 
    1190                 1195                 1200             


Asp Asn  Asp Asn Tyr Asn Leu  Ala Lys Gly Phe Asn  Tyr His Gln 
    1205                 1210                 1215             


Gly Pro  Glu Trp Leu Trp Pro  Ile Gly Tyr Phe Leu  Arg Ala Lys 
    1220                 1225                 1230             


Leu Tyr  Phe Ser Arg Leu Met  Gly Pro Glu Thr Thr  Ala Lys Thr 
    1235                 1240                 1245             


Ile Val  Leu Val Lys Asn Val  Leu Ser Arg His Tyr  Val His Leu 
    1250                 1255                 1260             


Glu Arg  Ser Pro Trp Lys Gly  Leu Pro Glu Leu Thr  Asn Glu Asn 
    1265                 1270                 1275             


Ala Gln  Tyr Cys Pro Phe Ser  Cys Glu Thr Gln Ala  Trp Ser Ile 
    1280                 1285                 1290             


Ala Thr  Ile Leu Glu Thr Leu  Tyr Asp Leu 
    1295                 1300             


<210>  11
<211>  1377
<212>  PRT
<213>  Equus caballus

<400>  11

Met Ile His Phe Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Ser 
1               5                   10                  15      


Tyr Ser Leu Ala Asp Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro 
            20                  25                  30          


Asn Lys Lys Tyr Thr Trp His Asp Val Gly Gln Leu Val Glu Lys Leu 
        35                  40                  45              


Lys Lys Glu Trp Asp Ile Leu Cys Ile Thr Asp Val Val Tyr Asn His 
    50                  55                  60                  


Thr Ala Ala Asn Ser Lys Trp Ile His Glu His Pro Glu Ser Ala Tyr 
65                  70                  75                  80  


Asn Leu Val Asn Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg 
                85                  90                  95      


Ala Leu Trp His Leu Ser Cys Asp Val Ala Glu Gly Lys Tyr Arg Glu 
            100                 105                 110         


Lys Gly Val Pro Ala Leu Ile Glu Asn Asp His Gln Met Asn Cys Ile 
        115                 120                 125             


Arg Lys Ile Ile Trp Glu Asp Ile Tyr Pro Lys Ile His Leu Trp Glu 
    130                 135                 140                 


Phe Phe Gln Val Asp Val His Lys Ala Val Glu Gln Phe Arg Gly Leu 
145                 150                 155                 160 


Leu Thr Gln Glu Asn Arg Lys Ile Ile Ser Gln Pro Asp Pro Lys Gln 
                165                 170                 175     


His Leu Lys Ile Ile Gln Asp Pro Glu Tyr Arg Arg Leu Gly Cys Thr 
            180                 185                 190         


Val Asp Met Asn Ile Ala Leu Ala Thr Phe Ile Pro His Asp Asn Gly 
        195                 200                 205             


Pro Ala Ala Ile Asp Glu Cys Cys Asn Trp Phe Arg Lys Arg Ile Glu 
    210                 215                 220                 


Glu Leu Asn Ala Glu Lys His Gln Leu Val Asn Tyr His Gln Glu Gln 
225                 230                 235                 240 


Ala Val Asn Cys Leu Leu Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly 
                245                 250                 255     


His Gly Pro Lys Leu Gly Pro Val Thr Arg Lys His Pro Leu Val Thr 
            260                 265                 270         


Arg Tyr Phe Thr Phe Pro Phe Glu Glu Met Thr Pro Ser Thr Glu Glu 
        275                 280                 285             


Ser Met Ile His Leu Pro Asn Lys Ala Cys Phe Leu Met Ala His Asn 
    290                 295                 300                 


Gly Trp Val Met Gly Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly 
305                 310                 315                 320 


Ser Asp Val Tyr Leu Arg Arg Glu Leu Ile Cys Trp Gly Asp Ser Val 
                325                 330                 335     


Lys Leu Arg Tyr Gly Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala 
            340                 345                 350         


His Met Lys Lys Tyr Thr Glu Ile Thr Ala Thr His Phe Gln Gly Val 
        355                 360                 365             


Arg Leu Asp Asn Cys His Ser Thr Pro Ile His Val Ala Glu Tyr Met 
    370                 375                 380                 


Leu Asp Ala Ala Arg Lys Leu Gln Pro Asn Leu Tyr Val Val Ala Glu 
385                 390                 395                 400 


Leu Phe Thr Gly Ser Glu Asp Leu Asp Asn Ile Phe Val Thr Arg Leu 
                405                 410                 415     


Gly Ile Ser Ser Leu Ile Arg Glu Ala Met Ser Ala Ala Asp Ser His 
            420                 425                 430         


Glu Glu Gly Arg Leu Val Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser 
        435                 440                 445             


Phe Val Gln Pro Cys Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala 
    450                 455                 460                 


Leu Phe Met Asp Ile Thr His Asp Asn Glu Cys Pro Ile Val His Arg 
465                 470                 475                 480 


Ser Ala Tyr Asp Ala Leu Pro Ser Ser Thr Ile Val Ser Met Ala Ser 
                485                 490                 495     


Cys Ala Ser Gly Ser Thr Lys Gly Tyr Asp Glu Leu Val Pro His Gln 
            500                 505                 510         


Ile Ser Val Val Ser Glu Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu 
        515                 520                 525             


Ala Leu Pro Ser Asn Thr Gly Glu Val Asn Phe Gln Ser Gly Ile Ile 
    530                 535                 540                 


Ala Ala Arg Arg Ala Ile Asn Lys Leu His Gln Glu Leu Gly Ala Lys 
545                 550                 555                 560 


Gly Phe Ile Gln Val Tyr Val Asp Gln Val Asp Gln Asp Ile Val Ala 
                565                 570                 575     


Val Thr Arg His Ser Pro Ser Ile His Gln Ser Val Val Ser Val Ser 
            580                 585                 590         


Arg Thr Ala Phe Arg Asn Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val 
        595                 600                 605             


Pro His Met Tyr Ile Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala 
    610                 615                 620                 


Arg Thr Ile Glu Arg His Thr Ile Pro Tyr Lys Lys Asp Glu Asn Ser 
625                 630                 635                 640 


Ile Asn Gly Met Pro Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln 
                645                 650                 655     


Leu Asn Glu Ser Lys Ile Val Lys His Ala Gly Ile Val Thr Lys Gly 
            660                 665                 670         


Pro Asn Glu Phe Val Gln Glu Ile Glu Phe Glu Asn Leu Thr Pro Gly 
        675                 680                 685             


Ser Val Ile Ile Phe Arg Val Ser Leu Asp Pro His Ala Gln Val Ala 
    690                 695                 700                 


Val Gly Ile Leu Arg Asn His Leu Thr Gln Phe Ser Pro His Phe Lys 
705                 710                 715                 720 


Ser Gly Ser Leu Ala Val Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro 
                725                 730                 735     


Phe Ala Ser Ile Ala Ser Lys Leu Thr Leu Ala Glu Leu Asn Gln Val 
            740                 745                 750         


Leu Tyr Arg Cys Glu Ser Glu Glu Gln Glu Asp Gly Gly Gly Cys Tyr 
        755                 760                 765             


Asn Ile Pro Asn Trp Ser Ser Leu Lys Tyr Ala Gly Leu Gln Gly Leu 
    770                 775                 780                 


Met Ser Ile Leu Ala Glu Ile Arg Pro Arg Asn Asp Leu Gly His Pro 
785                 790                 795                 800 


Phe Cys Asp Asn Leu Arg Ser Gly Asp Trp Met Ile Asp Tyr Val Ser 
                805                 810                 815     


Ser Arg Leu Ile Ser Arg Ser Gly Thr Ile Ala Glu Val Gly Lys Trp 
            820                 825                 830         


Leu Gln Ala Met Phe Leu Tyr Leu Lys Gln Ile Pro Arg Tyr Leu Ile 
        835                 840                 845             


Pro Cys Tyr Phe Asp Ala Ile Leu Ile Gly Ala Tyr Thr Thr Leu Leu 
    850                 855                 860                 


Asp Ile Ala Trp Lys Gln Met Ser Ser Phe Val Gln Asn Gly Ser Thr 
865                 870                 875                 880 


Phe Val Lys His Leu Ser Leu Gly Ser Val Gln Met Cys Gly Val Gly 
                885                 890                 895     


Lys Phe Pro Ser Leu Pro Leu Leu Ser Pro Ser Leu Thr Asp Leu Pro 
            900                 905                 910         


Tyr Arg Val Asn Glu Ile Thr Lys Glu Lys Glu Gln Cys Cys Gly Ser 
        915                 920                 925             


Leu Ala Ala Gly Leu Pro His Phe Ser Ala Gly Ile Phe Arg Cys Trp 
    930                 935                 940                 


Gly Arg Asp Thr Phe Ile Ala Leu Arg Gly Leu Leu Leu Val Thr Gly 
945                 950                 955                 960 


Arg Tyr Leu Glu Ala Arg Asn Ile Ile Leu Ala Phe Ala Gly Thr Leu 
                965                 970                 975     


Arg His Gly Leu Ile Pro Asn Leu Leu Gly Glu Gly Thr His Ala Arg 
            980                 985                 990         


Tyr Asn Cys Arg Asp Ala Val Trp  Trp Trp Leu Gln Cys  Ile Gln Asp 
        995                 1000                 1005             


Tyr Cys  Lys Ile Val Pro Asn  Gly Leu Asp Ile Leu  Arg Cys Pro 
    1010                 1015                 1020             


Val Ser  Arg Met Tyr Pro Thr  Asp Asp Ser Val Pro  Leu Ser Ala 
    1025                 1030                 1035             


Gly Thr  Val Asp Gln Pro Leu  Phe Glu Val Ile Gln  Glu Ala Met 
    1040                 1045                 1050             


Gln Arg  His Val Gln Gly Ile  Gln Phe Arg Glu Arg  Asn Ala Gly 
    1055                 1060                 1065             


Pro Gln  Ile Asp Arg Asn Met  Lys Asp Glu Gly Phe  Asn Ile Thr 
    1070                 1075                 1080             


Ala Gly  Val Asp Glu Glu Thr  Gly Phe Val Tyr Gly  Gly Asn Arg 
    1085                 1090                 1095             


Phe Asn  Cys Gly Thr Trp Met  Asp Lys Met Gly Glu  Ser Asp Arg 
    1100                 1105                 1110             


Ala Arg  Asn Arg Gly Ile Pro  Ala Thr Pro Arg Asp  Gly Ser Ala 
    1115                 1120                 1125             


Val Glu  Ile Val Gly Leu Ser  Lys Ser Ala Val Arg  Trp Leu Leu 
    1130                 1135                 1140             


Glu Leu  Ser Arg Lys Asn Ile  Phe Pro Tyr His Glu  Val Arg Val 
    1145                 1150                 1155             


Lys Arg  His Gly Lys Phe Val  Thr Val Ser Tyr Asp  Glu Trp Asn 
    1160                 1165                 1170             


Arg Lys  Ile Gln Asp Asn Phe  Glu Lys Leu Phe His  Val Ser Glu 
    1175                 1180                 1185             


Asp Pro  Ser Asp Phe Asn Glu  Lys His Pro Glu Leu  Val His Lys 
    1190                 1195                 1200             


Arg Gly  Ile Tyr Lys Asp Ser  Tyr Gly Ala Ser Ser  Pro Trp Cys 
    1205                 1210                 1215             


Asp Tyr  Gln Leu Arg Pro Asn  Phe Thr Ile Ala Met  Val Val Ala 
    1220                 1225                 1230             


Pro Glu  Leu Phe Thr Pro Glu  Lys Ala Trp Lys Ala  Leu Glu Ile 
    1235                 1240                 1245             


Ala Glu  Lys Lys Leu Leu Gly  Pro Leu Gly Met Lys  Thr Leu Asp 
    1250                 1255                 1260             


Pro Asp  Asp Met Val Tyr Cys  Gly Ile Tyr Asp Asn  Ala Leu Asp 
    1265                 1270                 1275             


Asn Asp  Asn Tyr Asn Leu Ala  Lys Gly Phe Asn Tyr  His Gln Gly 
    1280                 1285                 1290             


Pro Glu  Trp Leu Trp Pro Thr  Gly Tyr Phe Leu Arg  Ala Lys Leu 
    1295                 1300                 1305             


Tyr Phe  Ser Lys Leu Met Gly  Pro Glu Thr Asn Ala  Lys Thr Met 
    1310                 1315                 1320             


Phe Leu  Val Lys Asn Val Leu  Ser Arg His Tyr Val  His Leu Glu 
    1325                 1330                 1335             


Arg Ser  Pro Trp Lys Gly Leu  Pro Glu Leu Thr Asn  Glu Asn Gly 
    1340                 1345                 1350             


Gln Tyr  Cys Pro Phe Ser Cys  Glu Thr Gln Ala Trp  Ser Ile Ala 
    1355                 1360                 1365             


Thr Val  Leu Glu Thr Leu Tyr  Asp Leu 
    1370                 1375         


<210>  12
<211>  1365
<212>  PRT
<213>  Gorilla gorilla

<400>  12

Met Gly His Ser Lys Gln Ile Arg Ile Leu Leu Leu Asn Glu Met Glu 
1               5                   10                  15      


Lys Leu Glu Lys Thr Leu Phe Arg Leu Glu Gln Gly Tyr Glu Leu Gln 
            20                  25                  30          


Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val Tyr Thr 
        35                  40                  45              


Asn Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser 
    50                  55                  60                  


Leu Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp Lys Tyr 
65                  70                  75                  80  


Cys Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu 
                85                  90                  95      


Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile 
            100                 105                 110         


Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr 
        115                 120                 125             


Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu 
    130                 135                 140                 


Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe 
145                 150                 155                 160 


Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala 
                165                 170                 175     


Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr 
            180                 185                 190         


Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp 
        195                 200                 205             


Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn 
    210                 215                 220                 


Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn 
225                 230                 235                 240 


Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg 
                245                 250                 255     


Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro 
            260                 265                 270         


Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile 
        275                 280                 285             


Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val 
    290                 295                 300                 


Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu 
305                 310                 315                 320 


Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile 
                325                 330                 335     


Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile 
            340                 345                 350         


Ala Leu Thr Thr Phe Ile Pro His Glu Tyr Phe Thr Phe Pro Phe Glu 
        355                 360                 365             


Glu Ile Asp Phe Ser Met Glu Glu Ser Met Ile His Leu Pro Asn Lys 
    370                 375                 380                 


Ala Cys Phe Leu Met Ala His Asn Gly Trp Val Met Gly Asp Asp Pro 
385                 390                 395                 400 


Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu Arg Arg Glu 
                405                 410                 415     


Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly Asn Lys Pro 
            420                 425                 430         


Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr Thr Glu Ile 
        435                 440                 445             


Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys His Ser Thr 
    450                 455                 460                 


Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg Asn Leu Gln 
465                 470                 475                 480 


Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser Glu Asp Leu 
                485                 490                 495     


Asp Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu Ile Arg Glu 
            500                 505                 510         


Ala Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu Val Tyr Arg 
        515                 520                 525             


Tyr Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys Leu Arg Pro 
    530                 535                 540                 


Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile Thr His Asp 
545                 550                 555                 560 


Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala Leu Pro Ser 
                565                 570                 575     


Thr Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser Thr Arg Gly 
            580                 585                 590         


Tyr Asp Glu Leu Val Pro His Gln Phe Leu Gly Lys Ile Glu Glu Val 
        595                 600                 605             


Val Leu Glu Ala Arg Thr Ile Glu Arg Asn Met Lys Pro Tyr Arg Lys 
    610                 615                 620                 


Asp Glu Asn Ser Ile Asn Gly Thr Pro Asp Ile Thr Val Glu Ile Arg 
625                 630                 635                 640 


Glu His Ile Gln Leu Asn Glu Ser Lys Ile Val Lys Gln Ala Gly Val 
                645                 650                 655     


Ala Thr Lys Gly Pro Asn Glu Tyr Ile Gln Glu Ile Glu Phe Glu Asn 
            660                 665                 670         


Leu Ser Pro Gly Ser Val Ile Ile Phe Arg Val Ser Leu Asp Pro His 
        675                 680                 685             


Ala Gln Val Ala Val Gly Ile Leu Arg Asn His Leu Thr Gln Phe Ser 
    690                 695                 700                 


Pro His Phe Lys Ser Gly Ser Leu Ala Val Asp Asn Ala Asp Pro Ile 
705                 710                 715                 720 


Leu Lys Ile Pro Phe Ala Ser Ile Ala Ser Arg Leu Thr Leu Ala Glu 
                725                 730                 735     


Leu Asn Gln Ile Leu Tyr Arg Cys Glu Ser Glu Glu Lys Glu Asp Gly 
            740                 745                 750         


Gly Gly Cys Tyr Asp Ile Pro Asn Trp Ser Ala Leu Lys Tyr Ala Gly 
        755                 760                 765             


Leu Gln Gly Leu Met Ser Val Leu Ala Glu Ile Arg Pro Lys Asn Asp 
    770                 775                 780                 


Leu Gly His Pro Phe Cys Asn Asn Leu Arg Ser Gly Asp Trp Met Ile 
785                 790                 795                 800 


Asp Tyr Val Ser Asn Arg Leu Ile Ser Arg Ser Gly Thr Ile Ala Glu 
                805                 810                 815     


Val Gly Lys Trp Leu Gln Ala Met Phe Phe Tyr Leu Lys Gln Ile Pro 
            820                 825                 830         


Arg Tyr Leu Ile Pro Cys Tyr Phe Asp Ala Ile Leu Ile Gly Ala Tyr 
        835                 840                 845             


Thr Thr Leu Leu Asp Thr Ala Trp Lys Gln Met Ser Ser Phe Val Gln 
    850                 855                 860                 


Asn Gly Ser Thr Phe Val Lys His Leu Ser Leu Gly Ser Val Gln Leu 
865                 870                 875                 880 


Cys Gly Val Gly Lys Phe Pro Ser Leu Pro Ile Leu Ser Pro Ala Leu 
                885                 890                 895     


Met Asp Val Pro Tyr Arg Leu Asn Glu Ile Thr Lys Glu Lys Glu Gln 
            900                 905                 910         


Cys Cys Val Ser Leu Ala Ala Gly Leu Pro His Phe Ser Ser Gly Ile 
        915                 920                 925             


Phe Arg Cys Trp Gly Arg Asp Thr Phe Ile Ala Leu Arg Gly Ile Leu 
    930                 935                 940                 


Leu Ile Thr Gly Arg Tyr Val Glu Ala Arg Asn Ile Ile Leu Ala Phe 
945                 950                 955                 960 


Ala Gly Thr Leu Arg His Gly Leu Ile Pro Asn Leu Leu Gly Glu Gly 
                965                 970                 975     


Ile Tyr Ala Arg Tyr Asn Cys Arg Asp Ala Val Trp Trp Trp Leu Gln 
            980                 985                 990         


Cys Ile Gln Asp Tyr Cys Lys Met  Val Pro Asn Gly Val  Asp Ile Leu 
        995                 1000                 1005             


Lys Cys  Pro Val Ser Arg Met  Tyr Pro Thr Asp Asp  Ser Ala Pro 
    1010                 1015                 1020             


Leu Pro  Ala Gly Thr Leu Asp  Gln Pro Leu Phe Glu  Val Ile Gln 
    1025                 1030                 1035             


Glu Ala  Met Gln Lys His Met  Gln Gly Ile Gln Phe  Arg Glu Arg 
    1040                 1045                 1050             


Asn Ala  Gly Pro Gln Ile Asp  Arg Asn Met Lys Asp  Glu Gly Phe 
    1055                 1060                 1065             


Asn Ile  Thr Ala Gly Val Asp  Glu Glu Thr Gly Phe  Val Tyr Gly 
    1070                 1075                 1080             


Gly Asn  Arg Phe Asn Cys Gly  Thr Trp Met Asp Lys  Met Gly Glu 
    1085                 1090                 1095             


Ser Asp  Arg Ala Arg Asn Arg  Gly Ile Pro Ala Thr  Pro Arg Asp 
    1100                 1105                 1110             


Gly Ser  Ala Val Glu Ile Val  Gly Leu Ser Lys Ser  Ala Val Arg 
    1115                 1120                 1125             


Trp Leu  Leu Glu Leu Ser Lys  Lys Asn Ile Phe Pro  Tyr His Glu 
    1130                 1135                 1140             


Val Thr  Val Lys Arg His Gly  Lys Ala Ile Lys Val  Ser Tyr Asp 
    1145                 1150                 1155             


Glu Trp  Asn Arg Lys Ile Gln  Asp Asn Phe Glu Lys  Leu Phe His 
    1160                 1165                 1170             


Val Ser  Glu Asp Pro Ser Asp  Leu Asn Glu Lys His  Pro Asn Leu 
    1175                 1180                 1185             


Val His  Lys Arg Gly Ile Tyr  Lys Asp Ser Tyr Gly  Ala Ser Ser 
    1190                 1195                 1200             


Pro Trp  Cys Asp Tyr Gln Leu  Arg Pro Asn Phe Thr  Ile Ala Met 
    1205                 1210                 1215             


Val Val  Ala Pro Glu Leu Phe  Thr Thr Glu Lys Ala  Trp Lys Ala 
    1220                 1225                 1230             


Leu Glu  Ile Ala Glu Lys Lys  Leu Leu Gly Pro Leu  Gly Met Lys 
    1235                 1240                 1245             


Thr Leu  Asp Pro Asp Asp Met  Val Tyr Cys Gly Ile  Tyr Asp Asn 
    1250                 1255                 1260             


Ala Leu  Asp Asn Asp Asn Tyr  Asn Leu Ala Lys Gly  Phe Asn Tyr 
    1265                 1270                 1275             


His Gln  Gly Pro Glu Trp Leu  Trp Pro Ile Gly Tyr  Phe Leu Arg 
    1280                 1285                 1290             


Ala Lys  Leu Tyr Phe Ser Arg  Leu Met Gly Pro Glu  Thr Thr Ala 
    1295                 1300                 1305             


Lys Thr  Ile Val Leu Val Lys  Asn Val Leu Ser Arg  His Tyr Val 
    1310                 1315                 1320             


His Leu  Glu Arg Ser Pro Trp  Lys Gly Leu Pro Glu  Leu Thr Asn 
    1325                 1330                 1335             


Glu Asn  Ala Gln Tyr Cys Pro  Phe Ser Cys Glu Thr  Gln Ala Trp 
    1340                 1345                 1350             


Ser Ile  Ala Thr Ile Leu Glu  Thr Leu Tyr Asp Leu  
    1355                 1360                 1365 


<210>  13
<211>  1299
<212>  PRT
<213>  Pongo abelii

<400>  13

Met Gly His Ser Lys Gln Ile Arg Ile Leu Leu Leu Asn Glu Met Glu 
1               5                   10                  15      


Lys Leu Glu Lys Thr Leu Phe Arg Leu Glu Gln Gly Tyr Glu Leu Gln 
            20                  25                  30          


Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val Tyr Thr 
        35                  40                  45              


Asn Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser 
    50                  55                  60                  


Leu Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp Lys Tyr 
65                  70                  75                  80  


Cys Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu 
                85                  90                  95      


Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile 
            100                 105                 110         


Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr 
        115                 120                 125             


Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu 
    130                 135                 140                 


Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe 
145                 150                 155                 160 


Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala 
                165                 170                 175     


Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr 
            180                 185                 190         


Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp 
        195                 200                 205             


Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn 
    210                 215                 220                 


Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn 
225                 230                 235                 240 


Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg 
                245                 250                 255     


Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro 
            260                 265                 270         


Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile 
        275                 280                 285             


Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Glu Val 
    290                 295                 300                 


Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu 
305                 310                 315                 320 


Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile 
                325                 330                 335     


Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile 
            340                 345                 350         


Ala Leu Thr Thr Phe Ile Pro His Asp Asn Gly Pro Ala Ala Ile Glu 
        355                 360                 365             


Glu Cys Cys Asn Trp Phe Arg Lys Arg Ile Glu Glu Leu Asn Ser Glu 
    370                 375                 380                 


Lys His Gln Leu Ile Asn Tyr His Gln Glu Gln Ala Val Asn Cys Leu 
385                 390                 395                 400 


Leu Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His Gly Pro Lys Leu 
                405                 410                 415     


Gly Pro Val Thr Arg Lys His Pro Leu Val Thr Arg Tyr Phe Thr Phe 
            420                 425                 430         


Pro Phe Glu Glu Met Asp Phe Ser Met Glu Glu Ser Met Ile His Leu 
        435                 440                 445             


Pro Asn Lys Ala Cys Leu Leu Met Ala His Asn Gly Trp Val Met Gly 
    450                 455                 460                 


Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu 
465                 470                 475                 480 


Arg Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly 
                485                 490                 495     


Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr 
            500                 505                 510         


Thr Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys 
        515                 520                 525             


His Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg 
    530                 535                 540                 


Asn Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser 
545                 550                 555                 560 


Glu Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu 
                565                 570                 575     


Ile Arg Glu Ala Met Ser Ala Tyr Asp Ser His Glu Glu Gly Arg Leu 
            580                 585                 590         


Val Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys 
        595                 600                 605             


Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile 
    610                 615                 620                 


Thr His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala 
625                 630                 635                 640 


Leu Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser 
                645                 650                 655     


Thr Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile Ser Val Val Ser 
            660                 665                 670         


Glu Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu Ala Leu Pro Ser Asn 
        675                 680                 685             


Thr Gly Glu Val Asn Phe Gln Ser Gly Ile Ile Ala Ala Arg Cys Ala 
    690                 695                 700                 


Ile Asn Lys Leu His Gln Glu Leu Gly Ala Lys Gly Phe Ile Gln Val 
705                 710                 715                 720 


Tyr Val Asp Gln Val Asp Glu Asp Ile Val Ala Val Thr Arg His Ser 
                725                 730                 735     


Pro Ser Ile His Gln Ser Val Val Ala Val Ser Arg Thr Ala Phe Arg 
            740                 745                 750         


Asn Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val Pro Gln Met Cys Ile 
        755                 760                 765             


Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg Thr Ile Glu Arg 
    770                 775                 780                 


Asn Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro 
785                 790                 795                 800 


Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu Asn Glu Ser Lys 
                805                 810                 815     


Ile Val Lys Gln Ala Gly Val Ala Thr Lys Gly Pro Asn Glu Phe Ile 
            820                 825                 830         


Gln Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly Ser Val Ile Ile Phe 
        835                 840                 845             


Arg Val Ser Leu Asp Pro His Ala Gln Val Ala Val Gly Ile Leu Arg 
    850                 855                 860                 


Asn His Leu Thr Gln Phe Ser Pro His Phe Lys Ser Gly Ser Leu Ala 
865                 870                 875                 880 


Val Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro Phe Ala Leu Pro His 
                885                 890                 895     


Phe Ser Ser Gly Ile Phe Arg Cys Trp Gly Arg Asp Thr Phe Ile Ala 
            900                 905                 910         


Leu Arg Gly Met Leu Leu Ile Thr Gly Arg Tyr Val Glu Ala Arg Asn 
        915                 920                 925             


Ile Ile Leu Ala Phe Ala Gly Thr Leu Arg His Gly Leu Ile Pro Asn 
    930                 935                 940                 


Leu Leu Gly Glu Gly Thr Tyr Ala Arg Tyr Asn Cys Arg Asp Ala Val 
945                 950                 955                 960 


Trp Trp Trp Leu Gln Cys Ile Gln Asp Tyr Cys Lys Val Val Pro Asn 
                965                 970                 975     


Gly Leu Asp Ile Leu Lys Cys Pro Val Ser Arg Met Tyr Pro Thr Asp 
            980                 985                 990         


Asp Ser Ala Pro Leu Pro Ala Gly  Ala Leu Phe Asn Ile  Thr Ala Gly 
        995                 1000                 1005             


Val Asp  Glu Glu Thr Gly Phe  Val Tyr Gly Gly Asn  Arg Phe Asn 
    1010                 1015                 1020             


Cys Gly  Thr Trp Met Asp Lys  Met Gly Glu Ser Asp  Arg Ala Arg 
    1025                 1030                 1035             


Asn Arg  Gly Ile Pro Ala Thr  Pro Arg Asp Gly Ser  Ala Val Glu 
    1040                 1045                 1050             


Ile Val  Gly Leu Ser Lys Ser  Ala Val Arg Trp Leu  Leu Glu Leu 
    1055                 1060                 1065             


Ser Lys  Lys Asn Ile Phe Pro  Tyr His Glu Val Thr  Val Lys His 
    1070                 1075                 1080             


Gly Lys  Ala Ile Lys Val Ser  Tyr Asp Glu Trp Asn  Arg Lys Ile 
    1085                 1090                 1095             


Gln Asp  Asn Phe Glu Lys Leu  Phe His Val Ser Glu  Asp Pro Ser 
    1100                 1105                 1110             


Asp Leu  Asn Glu Lys His Pro  Asn Leu Val His Lys  Arg Gly Ile 
    1115                 1120                 1125             


Tyr Lys  Asp Ser Tyr Gly Ala  Ser Ser Pro Trp Cys  Asp Tyr Gln 
    1130                 1135                 1140             


Leu Arg  Pro Asn Phe Thr Ile  Ala Met Val Val Ala  Pro Glu Leu 
    1145                 1150                 1155             


Phe Thr  Thr Glu Lys Ala Trp  Lys Ala Leu Glu Ile  Ala Glu Lys 
    1160                 1165                 1170             


Lys Leu  Leu Gly Pro Leu Gly  Met Lys Thr Leu Asp  Pro Asp Asp 
    1175                 1180                 1185             


Met Val  Tyr Cys Gly Ile Tyr  Asp Asn Ala Leu Asp  Asn Asp Asn 
    1190                 1195                 1200             


Tyr Asn  Leu Ala Lys Gly Phe  Asn Tyr His Gln Gly  Pro Glu Trp 
    1205                 1210                 1215             


Leu Trp  Pro Ile Gly Tyr Phe  Leu Arg Ala Lys Leu  Tyr Phe Ser 
    1220                 1225                 1230             


Arg Leu  Met Gly Pro Glu Thr  Thr Ala Lys Thr Ile  Val Leu Val 
    1235                 1240                 1245             


Lys Asn  Val Leu Ser Arg His  Tyr Val His Leu Glu  Arg Ser Pro 
    1250                 1255                 1260             


Trp Lys  Gly Leu Pro Glu Leu  Thr Asn Glu Asn Ala  Gln Tyr Cys 
    1265                 1270                 1275             


Pro Phe  Ser Cys Glu Thr Gln  Ala Trp Ser Val Ala  Thr Ile Leu 
    1280                 1285                 1290             


Glu Thr  Leu Tyr Asp Leu 
    1295                 


<210>  14
<211>  1390
<212>  PRT
<213>  Pteropus alecto

<400>  14

Met Gly His Gly Lys Gln Ile Arg Ile Leu Leu Leu Asn Glu Met Glu 
1               5                   10                  15      


Lys Leu Glu Lys Thr Leu Phe Arg Leu Glu Gln Gly Phe Glu Leu Gln 
            20                  25                  30          


Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Thr Val Thr Val His Thr 
        35                  40                  45              


Asn Tyr Pro Tyr Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser 
    50                  55                  60                  


Leu Glu Trp Glu Asn Pro Ser Glu Arg Glu Asp Asp Ser Asp Lys Tyr 
65                  70                  75                  80  


Cys Lys Leu Asn Leu Gln Gln Ala Gly Ser Phe Gln Tyr Tyr Phe Leu 
                85                  90                  95      


Arg Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Val 
            100                 105                 110         


Leu Arg Val Gly Thr Asp Asn His Val Leu Pro Leu Asp Cys Val Thr 
        115                 120                 125             


Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Leu Asp Glu Trp Glu 
    130                 135                 140                 


Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe 
145                 150                 155                 160 


Thr Pro Leu Gln Thr Leu Gly Gln Ser Arg Ser Cys Tyr Ser Leu Ala 
                165                 170                 175     


Asp Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Lys Lys Cys 
            180                 185                 190         


Thr Trp Asp Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp 
        195                 200                 205             


Asn Ile Leu Cys Ile Thr Asp Val Val Tyr Asn His Thr Gly Asn Arg 
    210                 215                 220                 


Lys Ile Thr Lys Pro Asp Pro Lys Glu His Leu Lys Ile Ile Gln Asp 
225                 230                 235                 240 


Pro Glu Tyr Arg Arg Leu Gly Cys Thr Val Asp Met Asn Ile Ala Leu 
                245                 250                 255     


Ala Thr Phe Ile Pro Asn Glu Tyr Phe Thr Phe Pro Phe Glu Glu Met 
            260                 265                 270         


Thr Leu Ser Thr Glu Glu Ser Met Ile His Leu Pro Asn Lys Ala Cys 
        275                 280                 285             


Phe Leu Met Ala His Asn Gly Trp Val Met Gly Asp Asp Pro Leu Arg 
    290                 295                 300                 


Asn Phe Ala Glu Pro Gly Ser Asp Val Tyr Leu Arg Arg Glu Leu Ile 
305                 310                 315                 320 


Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly Asn Lys Pro Glu Asp 
                325                 330                 335     


Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr Thr Glu Ile Thr Ala 
            340                 345                 350         


Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys His Ser Thr Pro Leu 
        355                 360                 365             


His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg Lys Leu Gln Pro Asn 
    370                 375                 380                 


Leu Tyr Ile Val Ala Glu Leu Phe Thr Gly Ser Glu Asp Leu Asp Asn 
385                 390                 395                 400 


Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu Ile Arg Glu Ala Met 
                405                 410                 415     


Ser Ala His Asp Ser His Glu Glu Gly Arg Leu Val Tyr Arg Tyr Gly 
            420                 425                 430         


Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys Leu Arg Pro Leu Met 
        435                 440                 445             


Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile Thr His Asp Asn Glu 
    450                 455                 460                 


Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala Leu Pro Ser Ser Met 
465                 470                 475                 480 


Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser Thr Lys Gly Tyr Asp 
                485                 490                 495     


Glu Leu Val Pro His Gln Val Tyr Val Asp Gln Val Asp Glu Asp Ile 
            500                 505                 510         


Val Ala Val Thr Arg His Ser Pro Ser Ile His Gln Ser Val Val Ala 
        515                 520                 525             


Val Ser Arg Thr Ala Phe Lys Asn Pro Lys Thr Ser Phe Tyr Ser Lys 
    530                 535                 540                 


Glu Val Pro Gln Met Cys Ile Pro Gly Lys Ile Glu Glu Val Val Leu 
545                 550                 555                 560 


Glu Ala Arg Thr Ile Glu Arg Asn Thr Lys Pro Tyr Lys Arg Asp Glu 
                565                 570                 575     


Asn Ser Ile Asn Gly Met Pro Asp Ile Thr Ala Glu Ile Arg Glu His 
            580                 585                 590         


Ile Gln Leu Asn Glu Ser Lys Ile Val Lys Gln Ala Gly Ile Ala Thr 
        595                 600                 605             


Lys Gly Pro Asn Glu Tyr Ile Gln Glu Ile Glu Phe Glu Asn Leu Ser 
    610                 615                 620                 


Pro Gly Ser Val Ile Val Phe Arg Val Ser Leu Asp Pro His Ala Gln 
625                 630                 635                 640 


Val Ala Val Gly Ile Leu Arg Asn His Leu Thr Gln Phe Ser Pro His 
                645                 650                 655     


Phe Lys Ser Gly Ser Leu Ser Ala Asp Ser Ser Asp Pro Ile Leu Lys 
            660                 665                 670         


Ile Pro Phe Ala Tyr Ile Ala Ser Lys Leu Thr Leu Ala Glu Leu Asn 
        675                 680                 685             


Gln Ile Leu Tyr Arg Cys Glu Ser Glu Glu Gln Glu Asp Gly Gly Gly 
    690                 695                 700                 


Cys Tyr Asn Ile Pro Asn Trp Ser Ser Leu Lys Tyr Ala Gly Leu Gln 
705                 710                 715                 720 


Glu Asn Ser Ser Leu Glu Leu Ala Pro Tyr Val Gly Phe Gly Gly Gly 
                725                 730                 735     


Cys Gly Ala Ala Pro Ala Gly Leu Asn Arg Gly Gly Gly Val Arg Ser 
            740                 745                 750         


Asp Gln Ala Ser Leu Glu Arg Phe Leu Thr Thr Leu Leu Ala Thr Val 
        755                 760                 765             


Asp Tyr Thr Ala Leu Val Ser Thr Ser Val Cys Ser Pro His Ile Thr 
    770                 775                 780                 


Gly His Glu Gln Gln Pro Arg Leu Trp Glu Arg Ile Ala Ser Ala Asn 
785                 790                 795                 800 


Asn Ile Ala Cys Tyr Phe Tyr Asp Phe Ser Gly Leu Met Ser Val Leu 
                805                 810                 815     


Ala Glu Met Arg Pro Lys Asn Asp Leu Gly His Pro Phe Cys Asp Asn 
            820                 825                 830         


Leu Arg Ser Gly Asp Trp Met Ile Asp Tyr Val Ser Asn Arg Leu Ile 
        835                 840                 845             


Ser Arg Ser Gly Thr Ile Ala Glu Val Gly Arg Trp Leu Gln Ala Met 
    850                 855                 860                 


Phe Phe Tyr Leu Lys Gln Ile Pro Arg Tyr Leu Ile Pro Cys Tyr Phe 
865                 870                 875                 880 


Asp Ala Val Leu Ile Gly Ala Tyr Thr Thr Leu Leu Asp Thr Ala Trp 
                885                 890                 895     


Lys Gln Met Ser Ser Phe Val Gln Asn Gly Ser Thr Phe Val Lys His 
            900                 905                 910         


Leu Ser Leu Gly Ser Val Gln Leu Cys Gly Val Gly Lys Tyr Ala Ser 
        915                 920                 925             


Leu Pro Leu Leu Ser Pro Ser Leu Met Asp Val Pro Tyr Arg Leu Asn 
    930                 935                 940                 


Glu Ile Thr Lys Glu Lys Glu Gln Cys Cys Val Thr Leu Ala Ala Gly 
945                 950                 955                 960 


Leu Pro His Phe Ser Ser Gly Ile Phe Arg Cys Trp Gly Arg Asp Thr 
                965                 970                 975     


Phe Ile Ala Leu Arg Gly Ile Leu Leu Ile Thr Gly Arg Tyr Leu Glu 
            980                 985                 990         


Ala Arg Asn Ile Ile Leu Ala Phe  Ala Gly Thr Leu Arg  His Gly Leu 
        995                 1000                 1005             


Ile Pro  Asn Leu Leu Gly Glu  Gly Thr Tyr Ala Arg  Tyr Asn Cys 
    1010                 1015                 1020             


Arg Asp  Ala Val Trp Trp Trp  Leu Gln Cys Ile Gln  Asp Tyr Cys 
    1025                 1030                 1035             


Lys Val  Val Pro Asn Gly Leu  Asp Ile Leu Lys Cys  Pro Val Ser 
    1040                 1045                 1050             


Arg Met  Tyr Pro Thr Asp Asp  Ser Val Pro Leu Ser  Ala Gly Thr 
    1055                 1060                 1065             


Val Asp  Gln Pro Leu Phe Glu  Val Ile Gln Glu Ala  Met Gln Arg 
    1070                 1075                 1080             


His Met  Gln Gly Ile Gln Phe  Arg Glu Arg Asn Ala  Gly Pro Gln 
    1085                 1090                 1095             


Ile Asp  Arg Asn Met Lys Asp  Glu Gly Phe Asn Ile  Thr Val Gly 
    1100                 1105                 1110             


Val Asp  Glu Glu Thr Gly Phe  Val Tyr Gly Gly Asn  Arg Phe Asn 
    1115                 1120                 1125             


Cys Gly  Thr Trp Met Asp Lys  Met Gly Glu Ser Asp  Arg Ala Arg 
    1130                 1135                 1140             


Asn Arg  Gly Ile Pro Ala Thr  Pro Arg Asp Gly Ser  Ala Val Glu 
    1145                 1150                 1155             


Ile Val  Gly Leu Ser Lys Ser  Ala Ile Arg Trp Leu  Leu Glu Leu 
    1160                 1165                 1170             


Ser Lys  Lys Asn Ile Phe Pro  Tyr His Glu Val Thr  Val Lys Arg 
    1175                 1180                 1185             


Asp Gly  Lys Val Val Thr Val  Ser Tyr Asp Glu Trp  Asn Arg Lys 
    1190                 1195                 1200             


Ile Gln  Asp Asn Phe Glu Lys  Leu Phe Tyr Val Ser  Glu Asp Pro 
    1205                 1210                 1215             


Ser Asp  Phe Asn Glu Lys Asn  Pro Asn Leu Val His  Lys Arg Gly 
    1220                 1225                 1230             


Ile Tyr  Lys Asp Ser Tyr Gly  Ala Ser Ser Pro Trp  Cys Asp Tyr 
    1235                 1240                 1245             


Gln Leu  Arg Pro Asn Phe Thr  Ile Ala Met Val Val  Ala Pro Glu 
    1250                 1255                 1260             


Leu Phe  Thr Thr Glu Lys Ala  Trp Lys Ala Leu Gln  Val Ala Glu 
    1265                 1270                 1275             


Lys Lys  Leu Leu Gly Pro Leu  Gly Met Lys Thr Leu  Asp Pro Asp 
    1280                 1285                 1290             


Asp Met  Val Tyr Cys Gly Val  Tyr Asp Asn Ala Leu  Asp Asn Asp 
    1295                 1300                 1305             


Asn Tyr  Asn Leu Ala Lys Gly  Phe Asn Tyr His Gln  Gly Pro Glu 
    1310                 1315                 1320             


Trp Leu  Trp Leu Ile Gly Tyr  Phe Leu Arg Ala Lys  Leu Tyr Phe 
    1325                 1330                 1335             


Ser Lys  Leu Met Gly Pro Glu  Thr Asn Ala Lys Thr  Ile Phe Leu 
    1340                 1345                 1350             


Val Lys  Asn Val Leu Ser Arg  His Tyr Val His Leu  Glu Ser Leu 
    1355                 1360                 1365             


Ala Cys  Phe Ala Leu Thr Thr  Leu Leu Gln Leu Leu  Asn Lys Ile 
    1370                 1375                 1380             


Leu Ser  Ala Ser Gln Ile Pro  
    1385                 1390 


<210>  15
<211>  1252
<212>  PRT
<213>  Cercocebus atys

<400>  15

Met Asn Ser Ile Arg Lys Met Ile Trp Glu Asp Ile Phe Pro Lys Leu 
1               5                   10                  15      


Lys Leu Trp Glu Phe Phe Gln Val Asp Val Asn Lys Lys Lys Lys Lys 
            20                  25                  30          


Lys Lys Arg Leu Leu Thr Gln Glu Asn Arg Arg Val Thr Lys Ser Asp 
        35                  40                  45              


Pro His Gln His Leu Lys Ile Ile Gln Asp Pro Glu Tyr Arg Arg Phe 
    50                  55                  60                  


Gly Cys Thr Val Asp Met Asn Ile Ala Leu Thr Thr Phe Ile Pro His 
65                  70                  75                  80  


Asp Asn Gly Pro Ala Ala Ile Glu Glu Cys Cys Asn Trp Phe Arg Lys 
                85                  90                  95      


Arg Ile Glu Glu Leu Asn Ser Glu Lys His Arg Leu Ile Asn Tyr His 
            100                 105                 110         


Gln Glu Gln Ala Val Asn Cys Leu Leu Gly Asn Val Phe Tyr Glu Arg 
        115                 120                 125             


Leu Ala Gly His Gly Pro Lys Leu Gly Pro Val Thr Arg Lys His Pro 
    130                 135                 140                 


Leu Val Thr Arg Tyr Phe Thr Phe Pro Phe Glu Glu Met Asp Phe Ser 
145                 150                 155                 160 


Val Glu Glu Ser Met Ile His Leu Pro Asn Lys Ala Cys Phe Leu Met 
                165                 170                 175     


Ala His Asn Gly Trp Val Met Gly Asp Asp Pro Leu Arg Asn Phe Ala 
            180                 185                 190         


Glu Pro Gly Ser Glu Val Tyr Leu Arg Arg Glu Leu Ile Cys Trp Gly 
        195                 200                 205             


Asp Ser Val Lys Leu Arg Tyr Gly Asn Lys Pro Glu Asp Cys Pro Phe 
    210                 215                 220                 


Leu Trp Ala His Met Lys Lys Tyr Thr Glu Ile Thr Ala Thr Tyr Phe 
225                 230                 235                 240 


Gln Gly Val Arg Leu Asp Asn Cys His Ser Thr Pro Leu His Val Ala 
                245                 250                 255     


Glu Tyr Met Leu Asp Ala Ala Arg Asn Leu Gln Pro Asn Leu Tyr Val 
            260                 265                 270         


Val Ala Glu Leu Phe Thr Gly Ser Glu Asp Leu Asp Asn Ile Phe Val 
        275                 280                 285             


Thr Arg Leu Gly Ile Ser Ser Leu Ile Arg Glu Ala Met Ser Ala Tyr 
    290                 295                 300                 


Asn Ser His Glu Glu Gly Arg Leu Val Tyr Arg Tyr Gly Gly Glu Pro 
305                 310                 315                 320 


Val Gly Ser Phe Val Gln Pro Cys Leu Arg Pro Leu Met Pro Ala Ile 
                325                 330                 335     


Ala His Ala Leu Phe Met Asp Ile Thr His Asp Asn Glu Cys Pro Ile 
            340                 345                 350         


Val His Arg Ser Ala Tyr Asp Ala Leu Pro Ser Thr Thr Ile Val Ser 
        355                 360                 365             


Met Ala Cys Cys Ala Ser Gly Ser Thr Arg Gly Tyr Asp Glu Leu Val 
    370                 375                 380                 


Pro His Gln Ile Ser Val Val Ser Glu Glu Arg Phe Tyr Thr Lys Trp 
385                 390                 395                 400 


Asn Pro Gly Ala Leu Pro Ser Asn Thr Gly Glu Val Asn Phe Gln Ser 
                405                 410                 415     


Gly Ile Ile Ala Ala Arg Cys Ala Ile Asn Lys Leu His Gln Glu Leu 
            420                 425                 430         


Gly Ala Lys Gly Phe Ile Gln Val Tyr Val Asp Gln Val Asp Glu Asp 
        435                 440                 445             


Ile Val Ala Val Thr Arg His Ser Pro Ser Ile His Gln Ser Val Val 
    450                 455                 460                 


Ala Val Ser Arg Thr Ala Phe Arg Asn Pro Lys Thr Ser Phe Tyr Ser 
465                 470                 475                 480 


Lys Glu Val Pro Gln Met Cys Ile Pro Gly Lys Ile Glu Glu Val Val 
                485                 490                 495     


Leu Glu Ala Arg Thr Ile Glu Arg Asn Thr Lys Pro Tyr Arg Lys Asp 
            500                 505                 510         


Glu Asn Ser Ile Asn Gly Met Pro Asp Ile Thr Val Glu Ile Arg Glu 
        515                 520                 525             


His Ile Gln Leu Asn Glu Ser Lys Ile Val Lys Gln Ala Gly Val Ala 
    530                 535                 540                 


Thr Lys Gly Pro Asn Glu Tyr Ile Gln Glu Ile Glu Phe Glu Asn Leu 
545                 550                 555                 560 


Ser Pro Gly Ser Val Ile Ile Phe Arg Val Ser Leu Asp Pro His Ala 
                565                 570                 575     


Gln Val Ala Val Gly Ile Leu Arg Asn His Leu Thr Gln Phe Ser Pro 
            580                 585                 590         


His Phe Lys Ser Gly Ser Leu Ala Val Asp Asn Ser Asp Pro Ile Leu 
        595                 600                 605             


Lys Ile Pro Phe Ala Ser Ile Ala Ser Lys Leu Thr Leu Ala Glu Leu 
    610                 615                 620                 


Asn Gln Ile Leu Tyr Arg Cys Glu Ser Glu Glu Lys Glu Asp Gly Gly 
625                 630                 635                 640 


Gly Cys Tyr Asp Ile Pro Asn Trp Ser Ala Leu Lys Tyr Ala Gly Leu 
                645                 650                 655     


Gln Gly Leu Met Ser Val Leu Ala Glu Ile Arg Pro Lys Asn Asp Leu 
            660                 665                 670         


Gly His Pro Phe Cys Asn Asn Leu Arg Ser Gly Asp Trp Met Ile Asp 
        675                 680                 685             


Tyr Val Ser Asn Arg Leu Ile Ser Arg Ser Gly Thr Ile Ala Glu Val 
    690                 695                 700                 


Gly Lys Trp Leu Gln Ala Met Phe Phe Tyr Leu Lys Gln Ile Pro Arg 
705                 710                 715                 720 


Tyr Leu Ile Pro Cys Tyr Phe Asp Ala Ile Leu Ile Gly Ala Tyr Thr 
                725                 730                 735     


Thr Leu Leu Asp Ile Ala Trp Lys Gln Met Ser Ser Phe Val Gln Asn 
            740                 745                 750         


Gly Ser Thr Phe Val Lys His Leu Ser Leu Gly Ser Val Gln Leu Cys 
        755                 760                 765             


Gly Val Gly Lys Phe Pro Ser Leu Pro Ile Leu Ser Pro Ala Leu Thr 
    770                 775                 780                 


Gly Val Pro Tyr Arg Leu Asn Glu Ile Thr Lys Glu Lys Glu Gln Cys 
785                 790                 795                 800 


Cys Val Ser Leu Ala Ala Gly Leu Pro His Phe Ser Ser Gly Ile Phe 
                805                 810                 815     


Arg Cys Trp Gly Arg Asp Thr Phe Ile Ala Leu Arg Gly Ile Leu Leu 
            820                 825                 830         


Ile Thr Gly Arg Tyr Val Glu Ala Arg Asn Ile Ile Leu Ala Phe Ala 
        835                 840                 845             


Gly Thr Leu Arg His Gly Leu Ile Pro Asn Leu Leu Gly Glu Gly Thr 
    850                 855                 860                 


Tyr Ala Arg Tyr Asn Cys Arg Asp Ala Val Trp Trp Trp Leu Gln Cys 
865                 870                 875                 880 


Ile Gln Asp Tyr Cys Lys Met Val Pro Asn Gly Leu Asp Ile Leu Lys 
                885                 890                 895     


Cys Pro Val Ser Arg Met Tyr Pro Thr Asp Asp Ser Ala Pro Leu Pro 
            900                 905                 910         


Ala Gly Thr Leu Asp Gln Pro Leu Phe Glu Val Ile Gln Glu Ala Met 
        915                 920                 925             


Gln Arg His Met Gln Gly Ile Gln Phe Arg Glu Arg Asn Ala Gly Pro 
    930                 935                 940                 


Lys Ile Asp Arg Asn Met Lys Asp Glu Gly Phe Asn Val Thr Ala Gly 
945                 950                 955                 960 


Val Asp Glu Glu Thr Gly Phe Val Tyr Gly Gly Asn Arg Phe Asn Cys 
                965                 970                 975     


Gly Thr Trp Met Asp Lys Met Gly Glu Ser Asp Arg Ala Arg Asn Thr 
            980                 985                 990         


Gly Ile Pro Ala Thr Pro Arg Asp  Gly Ser Ala Val Glu  Ile Val Gly 
        995                 1000                 1005             


Leu Ser  Lys Ser Ala Val Arg  Trp Leu Leu Glu Leu  Ser Lys Lys 
    1010                 1015                 1020             


Asn Ile  Phe Pro Tyr His Glu  Val Thr Val Lys Arg  His Gly Lys 
    1025                 1030                 1035             


Val Val  Lys Val Ser Tyr Asp  Glu Trp Asn Arg Lys  Ile Gln Asp 
    1040                 1045                 1050             


Asn Phe  Glu Lys Leu Phe His  Val Ser Glu Asp Pro  Ser Asp Leu 
    1055                 1060                 1065             


Asn Glu  Lys His Pro Asn Leu  Val His Lys Arg Gly  Ile Tyr Lys 
    1070                 1075                 1080             


Asp Ser  Tyr Gly Ala Ser Ser  Pro Trp Cys Asp Tyr  Gln Leu Arg 
    1085                 1090                 1095             


Pro Asn  Phe Thr Ile Ala Met  Val Val Ala Pro Glu  Leu Phe Thr 
    1100                 1105                 1110             


Thr Ala  Lys Ala Trp Lys Ala  Leu Glu Ile Ala Glu  Lys Lys Leu 
    1115                 1120                 1125             


Leu Gly  Pro Leu Gly Met Lys  Thr Leu Asp Pro Asp  Asp Met Val 
    1130                 1135                 1140             


Tyr Cys  Gly Ile Tyr Asp Asn  Ala Leu Asp Asn Asp  Asn Tyr Asn 
    1145                 1150                 1155             


Leu Ala  Lys Gly Phe Asn Tyr  His Gln Gly Pro Glu  Trp Leu Trp 
    1160                 1165                 1170             


Pro Ile  Gly Tyr Phe Leu Arg  Ala Lys Leu Tyr Phe  Ser Arg Leu 
    1175                 1180                 1185             


Met Gly  Pro Glu Thr Thr Ala  Lys Thr Ile Val Leu  Val Lys Asn 
    1190                 1195                 1200             


Val Leu  Ser Arg His Tyr Val  His Leu Glu Arg Ser  Pro Trp Lys 
    1205                 1210                 1215             


Gly Leu  Pro Glu Leu Thr Asn  Glu Asn Ala Gln Tyr  Cys Pro Phe 
    1220                 1225                 1230             


Ser Cys  Glu Thr Gln Ala Trp  Ser Ile Ser Thr Ile  Leu Glu Thr 
    1235                 1240                 1245             


Leu Tyr  Asp Leu 
    1250         


<210>  16
<211>  1116
<212>  PRT
<213>  Ornithorhynchus anatinus

<400>  16

Met Phe Glu Gly Arg Ala Glu Gly Val Val Gly Glu Tyr Phe Thr Phe 
1               5                   10                  15      


Pro Tyr Gly Glu Met Thr Ser Val Glu Glu Glu Ser Leu Met His Gln 
            20                  25                  30          


Pro Glu Lys Ala Cys Phe Phe Met Ala His Asn Gly Trp Val Met Gly 
        35                  40                  45              


Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Asp Val Tyr Leu 
    50                  55                  60                  


Arg Arg Glu Leu Val Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly 
65                  70                  75                  80  


Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr 
                85                  90                  95      


Thr Glu Ile Thr Ala Lys Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys 
            100                 105                 110         


His Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg 
        115                 120                 125             


Lys Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser 
    130                 135                 140                 


Glu Glu Leu Asp Asn Ile Phe Val Thr Arg Leu Gly Ile Ser Ser Leu 
145                 150                 155                 160 


Ile Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu 
                165                 170                 175     


Val Tyr Arg Phe Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys 
            180                 185                 190         


Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile 
        195                 200                 205             


Thr His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala 
    210                 215                 220                 


Leu Pro Ser Ser Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser 
225                 230                 235                 240 


Thr Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile Ser Val Val Ser 
                245                 250                 255     


Glu Glu Arg Phe Tyr Thr Lys Trp Asn Pro Ala Ala Thr Leu Ser Asn 
            260                 265                 270         


Pro Ser Glu Val Asn Leu Gln Thr Gly Ile Ile Ala Gly Arg Arg Ala 
        275                 280                 285             


Ile Asn Lys Leu His Gln Glu Leu Gly Ala Lys Gly Phe Ile Gln Val 
    290                 295                 300                 


Tyr Val Asp Gln Val Asp Glu Asp Ile Val Ala Val Thr Arg His Cys 
305                 310                 315                 320 


Pro Ser Ser His Gln Ser Val Val Ala Val Ser Arg Thr Ala Phe Arg 
                325                 330                 335     


Asn Pro Lys Thr Ser Ala Tyr Ser Lys Glu Val Pro Gln Met Cys Ile 
            340                 345                 350         


Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg Thr Val Glu Arg 
        355                 360                 365             


Asn Val Gly Ser Tyr Val Lys Asp Ala Lys Ser Ile Asn Gly Met Pro 
    370                 375                 380                 


Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu Asn Glu Ser Lys 
385                 390                 395                 400 


Ile Val Lys Gln Ala Gly Val Ala Thr Lys Gly Leu His Glu Tyr Val 
                405                 410                 415     


Gln Glu Ile Glu Phe Glu Asn Leu Thr Pro Gly Ser Val Ile Ile Phe 
            420                 425                 430         


Arg Val Ser Leu Asp Pro His Ala Gln Val Ala Val Gly Ile Leu Arg 
        435                 440                 445             


Asn His Leu Thr Gln Phe Ser Pro Asn Phe Lys Ile Gly Ser Leu Pro 
    450                 455                 460                 


Val Asp Asn Ser Asp Pro Ile Leu Lys Ile Pro Phe Ala Ser Ile Ser 
465                 470                 475                 480 


Ser Lys Leu Thr Leu Ala Asp Leu Asn Gln Leu Leu Tyr Arg Cys Glu 
                485                 490                 495     


Ser Glu Glu Gln Glu Asp Gly Gly Gly Cys Tyr Asp Val Pro Asn Trp 
            500                 505                 510         


Ser Pro Leu Lys Tyr Gly Gly Leu Gln Gly Leu Met Ser Val Met Ala 
        515                 520                 525             


Glu Ile Arg Pro Lys Asn Asp Leu Gly His Pro Phe Cys Asn Asn Leu 
    530                 535                 540                 


Arg Ser Gly Asp Trp Met Ile Asp Tyr Val Ser Asn Arg Leu Ile Ser 
545                 550                 555                 560 


Arg Ser Gly Ser Ile Ala Glu Val Gly Lys Trp Phe Gln Ala Met Phe 
                565                 570                 575     


Phe Tyr Leu Lys Gln Ile Pro Arg Tyr Leu Ile Pro Cys Tyr Phe Asp 
            580                 585                 590         


Ala Ile Leu Ile Gly Ala Tyr Thr Thr Leu Leu Asp Ile Ala Trp Lys 
        595                 600                 605             


Gln Met Ser Ser Phe Val Gln Asn Gly Ser Thr Phe Val Lys His Leu 
    610                 615                 620                 


Ser Leu Gly Ser Val Gln Met Cys Gly Ile Gly Lys Phe Pro Ser Leu 
625                 630                 635                 640 


Pro Phe Leu Ser Pro Ser Leu Gly Asp Val Pro Tyr Arg Leu Asn Glu 
                645                 650                 655     


Ile Thr Gln Glu Lys Glu Gln Cys Cys Val Ser Leu Ala Ala Gly Leu 
            660                 665                 670         


Pro His Phe Ser Ser Gly Ile Phe Arg Cys Trp Gly Arg Asp Thr Phe 
        675                 680                 685             


Ile Ala Leu Arg Gly Leu Leu Leu Ile Thr Gly Arg Phe Leu Glu Ala 
    690                 695                 700                 


Arg Asn Ile Ile Leu Ala Phe Ala Gly Thr Leu Arg His Gly Leu Ile 
705                 710                 715                 720 


Pro Asn Leu Leu Gly Gln Gly Thr Tyr Ala Arg Phe Asn Cys Arg Asp 
                725                 730                 735     


Ala Val Trp Trp Trp Leu Gln Cys Ile Gln Asp Tyr Cys Lys Ile Val 
            740                 745                 750         


Pro Lys Gly Thr Asp Ile Leu Lys Cys Pro Val Ser Arg Met Tyr Pro 
        755                 760                 765             


Ser Asp Asp Ser Ser Ala Leu Pro Ala Gly Thr Leu Asp Gln Pro Leu 
    770                 775                 780                 


Tyr Glu Val Ile Gln Glu Ala Met Gln Arg His Met Gln Gly Ile Gln 
785                 790                 795                 800 


Phe Arg Glu Lys Asn Ala Gly Pro Gln Ile Asp Arg Asn Met Lys Asp 
                805                 810                 815     


Glu Gly Phe Asn Val Thr Ala Gly Val Asp Asp Glu Ser Gly Phe Val 
            820                 825                 830         


Tyr Gly Gly Asn His Phe Asn Cys Gly Thr Trp Met Asp Lys Met Gly 
        835                 840                 845             


Glu Ser Asp Arg Gly Arg Asn Arg Gly Ile Pro Ala Thr Pro Arg Asp 
    850                 855                 860                 


Gly Ser Ala Val Glu Ile Val Gly Leu Ser Lys Ser Thr Val Arg Trp 
865                 870                 875                 880 


Leu Val Glu Leu Ser Lys Lys Asn Val Phe Pro Tyr His Gly Val Thr 
                885                 890                 895     


Val Lys Arg Asn Glu Lys Glu Val Leu Ile Thr Tyr Asp Glu Trp Asn 
            900                 905                 910         


Arg Lys Ile Gln Asp His Phe Glu Lys Leu Phe Tyr Val Ser Glu Asp 
        915                 920                 925             


Pro Ser Asp Thr Asn Glu Lys His Pro Asn Leu Val His Lys Arg Gly 
    930                 935                 940                 


Ile Tyr Lys Asp Ser Tyr Gly Ala Ser Ser Pro Trp Cys Asp Tyr Gln 
945                 950                 955                 960 


Leu Arg Pro Asn Phe Thr Ile Ala Met Val Val Ala Pro Glu Leu Phe 
                965                 970                 975     


Thr Pro Gln Lys Ala Trp Lys Ala Leu Glu Ile Ala Glu Lys Lys Leu 
            980                 985                 990         


Leu Gly Pro Leu Gly Met Lys Thr  Leu Asp Pro Asp Asp  Met Val Tyr 
        995                 1000                 1005             


Cys Gly  Val Tyr Asp Asn Ala  Leu Asp Asn Asp Asn  Tyr Asn Leu 
    1010                 1015                 1020             


Ala Lys  Gly Phe Asn Tyr His  Gln Gly Pro Glu Trp  Leu Trp Pro 
    1025                 1030                 1035             


Val Gly  Tyr Phe Leu Arg Ala  Lys Leu Tyr Phe Ser  Lys Leu Met 
    1040                 1045                 1050             


Gly Gln  Glu Thr Tyr Thr Lys  Thr Val Phe Leu Ile  Lys Asn Val 
    1055                 1060                 1065             


Leu Ser  Arg His Tyr Val His  Leu Glu Arg Ser Pro  Trp Lys Gly 
    1070                 1075                 1080             


Leu Pro  Glu Leu Thr Asn Glu  Asn Gly Gln Tyr Cys  Ser Phe Ser 
    1085                 1090                 1095             


Cys Glu  Thr Gln Ala Trp Ser  Ile Ala Val Ile Leu  Glu Thr Leu 
    1100                 1105                 1110             


Tyr Asp  Leu 
    1115     


<210>  17
<211>  1304
<212>  PRT
<213>  Anas platyrhynchos

<400>  17

Met His Pro Glu Cys Gly Tyr Asn Leu Val Asn Ser Pro His Leu Lys 
1               5                   10                  15      


Pro Ala Trp Val Leu Asp Arg Ala Leu Trp His Leu Thr Cys Met Val 
            20                  25                  30          


Ala Asp Gly Lys Cys Ile Asp Lys Gly Val Pro Pro Leu Ile Glu Asn 
        35                  40                  45              


Asp His His Leu Asn Cys Val Arg Lys Ile Ile Trp Glu Glu Ile Tyr 
    50                  55                  60                  


Pro Lys Ile Lys Leu Trp Glu Phe Phe Gln Val Asp Val Asn Lys Ala 
65                  70                  75                  80  


Val Glu Gln Phe Arg Thr Leu Leu Thr Gln Gly Lys Glu Ser Lys Met 
                85                  90                  95      


Ser Thr Lys Ser Asp Pro Asn Gln His Leu Gln Ile Val Gln Asp Pro 
            100                 105                 110         


Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile Ala Leu Ala 
        115                 120                 125             


Thr Phe Ile Pro His Ser Asn Gly Pro Gly Ala Ile Glu Glu Cys Cys 
    130                 135                 140                 


Asn Trp Phe Arg Lys Arg Ile Glu Glu Leu Asn Ala Glu Gln His Arg 
145                 150                 155                 160 


Gln Ile His His His Gln Glu Gln Ala Val Asn Cys Leu Ala Gly Thr 
                165                 170                 175     


Val Val Tyr Glu Arg Leu Ala Gly His Gly Pro Lys Leu Gly Pro Ile 
            180                 185                 190         


Ser Arg Lys Tyr Pro Leu Val Thr Arg Tyr Phe Thr Tyr Pro Phe Lys 
        195                 200                 205             


Asp Met Thr Val Glu Glu Glu Glu Ala Met Ile His Arg Pro Asp Lys 
    210                 215                 220                 


Ala Cys Tyr Phe Met Ala His Asn Gly Trp Val Met Gly Asp Asp Pro 
225                 230                 235                 240 


Leu Arg Asn Phe Ala Glu Pro Gly Ser Asn Val Tyr Leu Arg Arg Glu 
                245                 250                 255     


Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly Asn Lys Pro 
            260                 265                 270         


Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr Thr Glu Ile 
        275                 280                 285             


Thr Ala Lys Tyr Phe His Gly Val Arg Leu Asp Asn Cys His Ser Thr 
    290                 295                 300                 


Pro Ile His Val Ala Glu Tyr Met Leu Asp Thr Ala Arg Lys Leu Arg 
305                 310                 315                 320 


Ala Asp Leu Phe Val Val Ala Glu Leu Phe Thr Gly Asn Glu Glu Leu 
                325                 330                 335     


Asp Asn Ile Phe Val Asn Arg Leu Gly Ile Thr Ser Leu Ile Arg Glu 
            340                 345                 350         


Ala Met Thr Ala Tyr Asn Ser His Glu Glu Gly Arg Leu Val Tyr Arg 
        355                 360                 365             


Phe Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Arg Leu Arg Pro 
    370                 375                 380                 


Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile Thr His Asp 
385                 390                 395                 400 


Asn Glu Cys Pro Ile Gln His Arg Ser Ala Tyr Asp Ala Leu Pro Ser 
                405                 410                 415     


Ala Met Ile Val Ser Met Ala Cys Cys Ala Thr Gly Ser Thr Lys Gly 
            420                 425                 430         


Tyr Asp Glu Leu Val Pro His Gln Ile Ser Val Val Ser Glu Glu Arg 
        435                 440                 445             


Phe Tyr Ser Thr Trp Asn Pro Ala Ala His Leu Thr Ser Gly Glu Val 
    450                 455                 460                 


Asn Phe Gln Thr Gly Ile Leu Ala Gly Arg Leu Ala Ile Asn Arg Leu 
465                 470                 475                 480 


His Gln Glu Leu Gly Ala Lys Gly Phe Asn Gln Val Tyr Val Asp Gln 
                485                 490                 495     


Val Asp Glu Asp Ile Val Ala Val Thr Arg His Cys Pro Asn Thr His 
            500                 505                 510         


Gln Ser Val Val Ala Val Ser Arg Thr Ala Phe Arg Asp Pro Lys Thr 
        515                 520                 525             


Ser Phe Tyr Ser Lys Glu Val Pro Glu Met Cys Ile Pro Gly Lys Ile 
    530                 535                 540                 


Glu Glu Val Val Leu Glu Ala Arg Thr Ile Glu Arg Asn Thr Asn Pro 
545                 550                 555                 560 


Tyr Lys Lys Asp Glu Arg Phe Ile Asn Gly Leu Pro Asn Phe Thr Val 
                565                 570                 575     


Glu Leu Arg Glu His Ile Gln Ile Lys Asp Ser Lys Ile Ile Lys Gln 
            580                 585                 590         


Ala Gly Thr Ala Ile Lys Gly Pro Asn Glu Phe Val Gln Glu Ile Glu 
        595                 600                 605             


Phe Glu Asn Leu Thr Pro Gly Ser Val Ile Val Phe Arg Val Ser Leu 
    610                 615                 620                 


Asp Pro Lys Ala Gln Glu Ala Val Gly Val Leu Arg Ser His Leu Ile 
625                 630                 635                 640 


Gln Phe Ser Pro His Phe Lys Ser Gly Ser Leu Pro Asp Asp His Ser 
                645                 650                 655     


Ala Pro Ile Leu Lys Thr Leu Phe Ser Ser Ile Ala Ser Lys Leu Ser 
            660                 665                 670         


Leu Ala Asp Leu Asn Gln Val Leu Tyr Arg Cys Glu Ala Glu Glu Gln 
        675                 680                 685             


Glu Asp Gly Gly Gly Cys Tyr Asn Ile Pro Asn Trp Ser Pro Leu Lys 
    690                 695                 700                 


Tyr Ala Gly Leu Gln Gly Leu Met Ser Val Met Ala Asp Ile Arg Pro 
705                 710                 715                 720 


Lys Asn Asp Leu Gly His Pro Phe Cys Asp Asn Leu Arg Ser Gly Asp 
                725                 730                 735     


Trp Met Ile Asp Tyr Val Ser Asn Arg Leu Ile Ser Arg Thr Gly Ala 
            740                 745                 750         


Cys Ala Glu Val Gly Lys Trp Leu Lys Ala Met Phe Ile Tyr Leu Lys 
        755                 760                 765             


Lys Ile Pro Arg Tyr Leu Ile Pro Cys Tyr Phe Asp Ala Ile Leu Val 
    770                 775                 780                 


Gly Ala Tyr Thr Thr Leu Leu Asp Val Gly Trp His Gln Met Ser Ser 
785                 790                 795                 800 


Phe Val Gln Asn Gly Ser Thr Phe Val Lys His Leu Ser Leu Gly Ser 
                805                 810                 815     


Ile Gln Met Cys Gly Ile Gly Lys Tyr Ser Cys Leu Pro Asp Leu Ser 
            820                 825                 830         


Pro Ser Leu His Asp Val Pro Tyr Arg Leu Asn Glu Ile Thr Asn Glu 
        835                 840                 845             


Lys Glu Gln Cys Cys Val Ser Leu Ala Ala Gly Leu Pro His Phe Ser 
    850                 855                 860                 


Ser Gly Ile Phe Arg Ser Trp Gly Arg Asp Thr Phe Ile Ala Leu Arg 
865                 870                 875                 880 


Gly Leu Met Leu Val Thr Gly Arg Tyr Leu Glu Ala Arg Asn Ile Ile 
                885                 890                 895     


Leu Ala Phe Gly Gly Thr Leu Arg His Gly Leu Ile Pro Asn Leu Leu 
            900                 905                 910         


Gly Gln Gly Thr His Ala Arg Tyr Asn Cys Arg Asp Ala Val Trp Trp 
        915                 920                 925             


Trp Leu Gln Cys Ile Gln Asp Tyr Cys Lys Ile Val Pro Asn Gly Leu 
    930                 935                 940                 


Asp Ile Leu Arg Cys Pro Val Ser Arg Met Tyr Pro Arg Asp Asp Ser 
945                 950                 955                 960 


Ser Pro Gln Pro Ala Gly Ser Val Asp Gln Pro Leu Tyr Glu Val Ile 
                965                 970                 975     


Gln Glu Ala Met Gln Arg His Met Glu Gly Ile Asn Phe Arg Glu Arg 
            980                 985                 990         


Asn Ala Gly Pro Gln Ile Asp Gln  Asn Met Arg Asp Glu  Gly Phe Asn 
        995                 1000                 1005             


Val Thr  Ala Gly Val Asp Arg  Glu Thr Gly Phe Val  Phe Gly Gly 
    1010                 1015                 1020             


Asn Arg  Phe Asn Cys Gly Thr  Trp Met Asp Lys Met  Gly Glu Ser 
    1025                 1030                 1035             


Asp Arg  Ala Arg Asn Arg Gly  Ile Pro Ala Thr Pro  Arg Asp Gly 
    1040                 1045                 1050             


Ser Ala  Val Glu Ile Val Gly  Leu Cys Lys Ser Thr  Val Arg Trp 
    1055                 1060                 1065             


Leu Leu  Asp Leu Ser Arg Lys  Asn Glu Phe Pro Phe  His Gly Val 
    1070                 1075                 1080             


Thr Ile  Lys Arg His Gly Lys  Glu Glu Thr Ile Thr  Tyr Asp Glu 
    1085                 1090                 1095             


Trp Asp  Arg Lys Ile Gln Ala  His Phe Glu Lys Leu  Phe Phe Val 
    1100                 1105                 1110             


Ser Glu  Asn Pro Ala Asp Pro  Asn Glu Lys His Pro  Asn Leu Val 
    1115                 1120                 1125             


His Lys  Arg Gly Ile Tyr Lys  Asp Ser Tyr Gly Ala  Ser Ser Pro 
    1130                 1135                 1140             


Trp Cys  Asp Tyr Gln Leu Arg  Pro Asn Phe Thr Ile  Ala Met Val 
    1145                 1150                 1155             


Val Ala  Pro Glu Leu Phe Thr  Pro Glu Arg Ala Trp  Lys Ala Leu 
    1160                 1165                 1170             


Gln Ile  Ala Glu Glu Lys Leu  Leu Gly Pro Leu Gly  Met Lys Thr 
    1175                 1180                 1185             


Leu Asp  Pro Asp Asp Met Val  Tyr Cys Gly Val Tyr  Asp Asn Ala 
    1190                 1195                 1200             


Leu Asp  Asn Asp Asn Tyr Asn  Val Ala Arg Gly Phe  Asn Tyr His 
    1205                 1210                 1215             


Gln Gly  Pro Glu Trp Leu Trp  Pro Ile Gly Tyr Phe  Leu Arg Ala 
    1220                 1225                 1230             


Lys Leu  Tyr Phe Ser Lys Leu  Ile Gly Pro Gln Ile  Tyr Ala Lys 
    1235                 1240                 1245             


Thr Val  Val Met Ile Lys Asn  Val Leu Ser Arg His  Tyr Val His 
    1250                 1255                 1260             


Leu Glu  Arg Ser Ser Trp Lys  Gly Leu Pro Glu Leu  Thr Asn Glu 
    1265                 1270                 1275             


Asn Gly  Gln Tyr Cys Pro Phe  Ser Cys Glu Thr Gln  Ala Trp Ser 
    1280                 1285                 1290             


Ile Ser  Val Ile Leu Glu Ile  Leu Tyr Asp Leu 
    1295                 1300                 


<210>  18
<211>  4131
<212>  DNA
<213>  artificial

<220>
<223>  Nucleic acid sequence encoding D1 hGDEWT

<400>  18
atgattcatt ttaccccatt gcagactctt ggactatcta ggtcatgcta ctcccttgcc       60

aatcagttag aattaaatcc tgacttttca agacctaata gaaagtatac ctggaatgat      120

gttggacagc tagtggaaaa attaaaaaag gaatggaatg ttatttgtat tactgatgtt      180

gtctacaatc atactgctgc taatagtaaa tggatccagg aacatccaga atgtgcctat      240

aatcttgtaa attctccaca cttaaaacct gcctgggtct tagacagagc actttggcgt      300

ttctcctgtg atgttgcaga agggaaatac aaagaaaagg gaatacctgc tttgattgaa      360

aatgatcacc atatgaactc catccgaaaa ataatttggg aggatatttt tccaaagctt      420

aaactctggg aatttttcca agtagatgtc aacaaagcgg ttgagcaatt tagaagactt      480

cttacacaag aaaataggcg agtaaccaag tctgatccaa accaacacct tacgattatt      540

caagatcctg aatacagacg gtttggctgt actgtagata tgaacattgc actaacgact      600

ttcataccac atgacaaggg gccagcagca attgaagaat gctgtaattg gtttcataaa      660

agaatggagg aattaaattc agagaagcat cgactcatta actatcatca ggaacaggca      720

gttaattgcc ttttgggaaa tgtgttttat gaacgactgg ctggccatgg tccaaaacta      780

ggacctgtca ctagaaagca tcctttagtt accaggtatt ttactttccc atttgaagag      840

atagacttct ccatggaaga atctatgatt catctgccaa ataaagcttg ttttctgatg      900

gcacacaatg gatgggtaat gggagatgat cctcttcgaa actttgctga accgggttca      960

gaagtttacc taaggagaga acttatttgc tggggagaca gtgttaaatt acgctatggg     1020

aataaaccag aggactgtcc ttatctctgg gcacacatga aaaaatacac tgaaataact     1080

gcaacttatt tccagggagt acgtcttgat aactgccact caacacctct tcacgtagct     1140

gagtacatgt tggatgctgc taggaatttg caacccaatt tatatgtagt agctgaactg     1200

ttcacaggaa gtgaggacct agacaatgtc tttgttacta gactgggcat tagttcctta     1260

ataagagagg caatgagtgc atataatagt catgaagagg gcagattagt ttaccgatat     1320

ggaggagaac ctgttggatc ctttgttcag ccctgtttga ggcctttaat gccagctatt     1380

gcacatgccc tgtttatgga tattacgcat gataatgagt gtcctattgt gcatagatca     1440

gcgtatgatg ctcttccaag tactacaatt gtttctatgg catgttgtgc tagtggaagt     1500

acaagaggct atgatgaatt agtgcctcat cagatttcag tggtttctga agaacggttt     1560

tacactaagt ggaatcctga agcattgcct tcaaacacag gtgaagttaa tttccaaagc     1620

ggcattattg cagccaggtg tgctatcagt aaacttcatc aggagcttgg agccaagggt     1680

tttattcagg tgtatgtgga tcaagttgat gaagacatag tggcagtaac aagacactca     1740

cctagcatcc atcagtctgt tgtggctgta actagaactg ctttcaggaa tcccaagact     1800

tcattttaca gcaaggaagt gcctcaaatg tgcatccctg gcaaaattga agaagtagtt     1860

cttgaagcta gaactattga gagaaacacg aaaccttata ggaaggatga aaattcaatc     1920

aatggaacac cagatatcac agtagaaatt agagaacata ttcagcttaa tgaaagtaaa     1980

attgttaaac aagctggagt tgccacaaaa gggcccaatg aatatattca agaaatagaa     2040

tttgaaaact tgtctccagg aagtgttatt atattcagag ttagtcttga tccacatgca     2100

caagtcgctg ttggcattct tcgaaatcat ctgacacaat tcagtcctca ctttaaatct     2160

ggcagcctag ctgttgacaa tgcagatcct atattaaaaa ttccttttgc ttctcttgcc     2220

tatagattaa ctttggctga gctaaatcag atcctttacc gatgtgaatc agaagaaaag     2280

gaagatggtg gagggtgcta tgacatacca aactggtcag cccttaaata tgcaggtctt     2340

caaggtttaa tgtctgtatt ggcagaaata agaccaaaga atgacttggg gcatcctttt     2400

tgtaataatt tgaggtctgg agattggatg attgactatg tcagtaaccg gcttatttca     2460

cgatcaggaa ctattgctga agttggtaaa tggttgcagg ctatgttctt ctacctgaag     2520

cagatcccac gttaccttat cccatgttac tttgatgcta tattaattgg tgcatatacc     2580

actcttctgg atacagcatg gaagcagatg tcaagctttg ttcagaatgg ttcaaccttt     2640

gtgaaacacc tttcattggg ttcagttcaa ctgtgtggag taggaaaatt cccttccctg     2700

ccaattcttt cacctgccct aatggatgta ccttataggt taaatgagat cacaaaagaa     2760

aaggagcaat gttgtgtttc tctagctgca ggcttacctc atttttcttc tggtattttc     2820

cgctgctggg gaagggatac ttttattgca cttagaggta tactgctgat tactggacgc     2880

tatgtagaag ccaggaatat tattttagca tttgcgggta ccctgaggca tggtctcatt     2940

cctaatctac tgggtgaagg aatttatgcc agatacaatt gtcgggatgc tgtgtggtgg     3000

tggctgcagt gtatccagga ttactgtaaa atggttccaa atggactaga cattctcaag     3060

tgcccagttt ccagaatgta tcctacagat gattctgctc ctttgcctgc tggcacactg     3120

gatcagccat tgtttgaagt catacaggaa gcaatgcaaa aacacatgca gggcatacag     3180

ttccgagaaa ggaatgctgg tccccagata gatcgaaaca tgaaggacga aggttttaat     3240

ataactgcag gagttgatga agaaacagga tttgtttatg gaggaaatcg tttcaattgt     3300

ggcacatgga tggataaaat gggagaaagt gacagagcta gaaacagagg aatcccagcc     3360

acaccaagag atgggtctgc tgtggaaatt gtgggcctga gtaaatctgc tgttcgctgg     3420

ttgctggaat tatccaaaaa aaatattttc ccttatcatg aagtcacagt aaaaagacat     3480

ggaaaggcta taaaggtctc atatgatgag tggaacagaa aaatacaaga caactttgaa     3540

aagctatttc atgtttccga agacccttca gatttaaatg aaaagcatcc aaatctggtt     3600

cacaaacgtg gcatatacaa agatagttat ggagcttcaa gtccttggtg tgactatcag     3660

ctcaggccta attttaccat agcaatggtt gtggcccctg agctctttac tacagaaaaa     3720

gcatggaaag ctttggagat tgcagaaaaa aaattgcttg gtccccttgg catgaaaact     3780

ttagatccag atgatatggt ttactgtgga atttatgaca acgcattaga caatgacaac     3840

tacaatcttg ctaaaggttt caattatcac caaggacctg agtggctgtg gcctattggg     3900

tattttcttc gtgcaaaatt atatttttcc agattgatgg gcccggagac tactgcaaag     3960

actatagttt tggttaaaaa tgttctttcc cgacattatg ttcatcttga gagatcccct     4020

tggaaaggac ttccagaact gaccaatgag aatgcccagt actgtccttt cagctgtgaa     4080

acacaagcct ggtcaattgc tactattctt gagacacttt atgatttata g              4131


<210>  19
<211>  4131
<212>  DNA
<213>  artificial

<220>
<223>  Nucleic acid sequence encoding D1 hGDE co2

<400>  19
atgatccact tcacccctct gcagaccctg ggcctgagca gaagctgtta cagcctggcc       60

aaccagctgg aactgaaccc cgacttcagc agacccaacc ggaagtacac ctggaacgat      120

gtgggccagc tggtggaaaa actgaagaaa gaatggaacg tgatctgcat caccgacgtg      180

gtgtacaacc acaccgccgc caacagcaag tggatccaag agcaccctga gtgcgcctac      240

aacctggtca acagccctca cctgaaacct gcctgggtgc tcgatagagc cctgtggcgg      300

tttagctgtg atgtggccga gggcaagtac aaagagaagg gcatccccgc tctgatcgag      360

aacgaccacc acatgaacag catccggaag atcatctggg aagatatttt ccccaagctg      420

aagctgtggg agttcttcca ggtggacgtg aacaaggccg tggaacagtt cagacggctg      480

ctgacccaag agaacagaag agtgaccaag agcgacccca accagcacct gaccatcatt      540

caggaccccg agtatcggag attcggctgc accgtggaca tgaatatcgc cctgaccacc      600

ttcattcccc acgacaaagg acctgccgcc atcgaggaat gctgcaactg gttccacaag      660

cggatggaag aattgaacag cgagaagcac cggctgatca actaccacca agagcaggcc      720

gtgaactgcc tgctgggcaa cgtgttctat gagagactgg ccggacacgg ccctaagctg      780

ggacctgtga caagaaagca ccctctggtt acccggtact tcacctttcc attcgaagag      840

atcgacttct ccatggaaga gagcatgatc catctgccta acaaggcctg cttcctgatg      900

gctcacaacg gctgggttat gggcgacgac cctctgagaa atttcgccga gcctggcagc      960

gaggtgtacc tgagaagaga actgatctgt tggggcgaca gcgtgaagct gagatacggc     1020

aacaagcccg aggactgccc ttacctgtgg gcccatatga agaagtacac agagatcacc     1080

gccacctact ttcagggcgt cagactggac aactgccaca gcacacctct gcacgtggcc     1140

gagtacatgc tggacgccgc tagaaatctg cagcccaacc tgtatgtggt ggccgagctg     1200

tttaccggct ccgaggacct ggacaatgtg ttcgtgacca gactgggcat cagcagcctg     1260

atcagagaag ccatgtccgc ctacaatagc cacgaagagg gcagactggt gtacagatat     1320

ggcggcgagc ctgtgggcag cttcgttcag ccttgtctga ggcctctgat gcccgccatt     1380

gctcacgccc tgttcatgga catcacccac gataacgagt gccccatcgt gcacagaagc     1440

gcctacgacg ctctgcctag caccaccatt gtgtccatgg cctgttgtgc cagcggcagc     1500

acaagaggct atgacgaact ggtgccccac cagatttccg tggtgtccga ggaacggttc     1560

tacaccaagt ggaaccccga ggctctgccc agcaataccg gcgaagtgaa tttccagagc     1620

ggcatcattg ccgccagatg cgccatcagc aagctgcacc aagaactggg cgccaagggc     1680

ttcattcagg tgtacgtgga ccaggtcgac gaggacattg tggccgtgac aagacacagc     1740

cccagcatcc atcagagcgt ggtggctgtg accagaaccg ccttcagaaa ccccaagacc     1800

agcttctaca gcaaagaggt gccccagatg tgcatccccg gcaagattga ggaagtggtg     1860

ctcgaggccc ggaccatcga gagaaacacc aagccttacc ggaaggacga gaactccatc     1920

aacggcaccc ctgacatcac cgtggaaatc agagagcaca tccagctcaa cgagagcaag     1980

atcgtgaaac aggccggcgt ggccacaaag ggccccaacg agtatatcca agagattgag     2040

ttcgagaatc tgagccccgg cagcgtgatc atcttcagag tgtccctgga tcctcacgct     2100

caggtggccg tgggcatcct gagaaatcac ctgacacagt tcagcccaca cttcaagagc     2160

ggaagcctgg ccgtggacaa cgccgatcct atcctgaaga tccccttcgc ctctctggcc     2220

tacagactga cactggctga gctgaaccag atcctgtaca gatgcgagtc cgaagagaaa     2280

gaggatggcg gaggctgcta cgacatcccc aattggagcg ccctgaagta tgccggactg     2340

cagggactga tgtctgtgct ggccgagatc agacccaaga acgacctggg acaccccttc     2400

tgcaacaacc tgagatccgg cgactggatg atcgactacg tgtccaacag actgatcagc     2460

agatccggca caatcgccga agtcggcaaa tggctgcagg ccatgttctt ctacctgaag     2520

cagatccctc ggtatctgat cccctgctac ttcgacgcca tcctgatcgg cgcctacacc     2580

acactgctgg ataccgcctg gaagcagatg tccagcttcg tgcagaacgg cagcaccttc     2640

gtgaagcacc tgtctctggg aagcgtgcag ctgtgtggcg tgggcaaatt tcccagcctg     2700

cctatcctgt ctcctgcact gatggacgtg ccctaccggc tgaatgagat caccaaagaa     2760

aaagagcagt gctgcgtcag cctggctgct ggcctgcctc atttttccag cggcatcttc     2820

cggtgttggg gcagagacac ctttattgcc ctgagaggca tcctgctgat taccggcaga     2880

tacgtggaag cccggaacat catcctggcc tttgccggca cactgcggca cggactgatt     2940

cctaatctgc tcggcgaggg catctacgcc agatacaact gcagagatgc cgtgtggtgg     3000

tggctccagt gcatccagga ctactgcaag atggtgccca acggcctgga catcctgaag     3060

tgccctgtgt ccagaatgta ccctaccgac gatagcgccc ctctgcctgc cggaacactt     3120

gaccagcctc tgttcgaagt gattcaagag gccatgcaga aacacatgca gggaatccag     3180

tttcgcgagc ggaatgccgg acctcagatc gacagaaaca tgaaggatga gggcttcaac     3240

atcaccgctg gcgtggacga agagacaggc tttgtgtacg gcggcaaccg gttcaattgc     3300

ggcacctgga tggacaagat gggcgagtct gaccgggcca gaaacagagg aattcccgcc     3360

acacctagag atggcagcgc tgtggaaatc gtgggcctgt ctaagtctgc tgtgcggtgg     3420

ctgctcgaac tgagcaagaa gaatatcttt ccgtaccacg aagtgaccgt gaagcggcac     3480

ggcaaggcca tcaaggtgtc ctacgacgag tggaacagaa agatccagga caacttcgaa     3540

aagctgttcc atgtgtctga ggaccccagc gacctgaacg aaaagcaccc caacctggtg     3600

cacaagcgcg gcatctacaa ggacagctac ggcgcctctt ctccttggtg cgattaccag     3660

ctgcggccca acttcaccat tgccatggtg gttgcccctg agctgttcac cacagagaag     3720

gcctggaagg ccctggaaat cgccgagaag aaactgctgg gccctctggg catgaagaca     3780

ctggaccccg acgacatggt gtactgcgga atctacgaca acgccctgga taacgacaac     3840

tacaatctgg ccaaggggtt caattaccat cagggacccg agtggctgtg gcctatcggc     3900

tatttcctgc gggccaagct gtacttctcc agactgatgg gccctgagac aaccgccaag     3960

acaatcgtgc tcgtgaagaa cgtgctgagc cggcactatg tgcacctgga aagaagcccc     4020

tggaagggac tgcccgagct gaccaatgag aacgcccagt actgcccctt cagctgcgaa     4080

acacaggcct ggtctatcgc caccatcctg gaaaccctgt acgacctgtg a              4131


<210>  20
<211>  4395
<212>  DNA
<213>  artificial

<220>
<223>  Nucleic acid sequence encoding D2 hGDE

<400>  20
atgggacaca gtaaacagat tcgaatttta cttctgaacg aaatggagaa actggaaaag       60

accctcttca gacttgaaca agggtatgag ctacagttcc gattaggccc aactttacag      120

ggaaaagcag ttaccgtgta tacaaattac ccatttcctg gagaaacatt taatagagaa      180

aaattccgtt ctctggattg ggaaaatcca acagaaagag aagatgattc tgataaatac      240

tgtaaactta atctgcaaca atctggttca tttcagtatt atttccttca aggaaatgag      300

aaaagtggtg gaggttacat agttgtggac cccattttac gtgttggtgc tgataatcat      360

gtgctaccct tggactgtgt tactcttcag acatttttag ctaagtgttt gggacctttt      420

gatgaatggg aaagcagact tagggttgca aaagaatcag gctacaacat gattcatttt      480

accccattgc agactcttgg actatctagg tcatgctact cccttgccaa tcagttagaa      540

ttaaatcctg acttttcaag acctaataga aagtatacct ggaatgatgt tggacagcta      600

gtggaaaaat taaaaaagga atggaatgtt atttgtatta ctgatgttgt ctacaatcat      660

actgctgcta atagtaaatg gatccaggaa catccagaat gtgcctataa tcttgtaaat      720

tctccacact taaaacctgc ctgggtctta gacagagcac tttggcgttt ctcctgtgat      780

gttgcagaag ggaaatacaa agaaaaggga atacctgctt tgattgaaaa tgatcaccat      840

atgaactcca tccgaaaaat aatttgggag gatatttttc caaagcttaa actctgggaa      900

tttttccaag tagatgtcaa caaagcggtt gagcaattta gaagacttct tacacaagaa      960

aataggcgag taaccaagtc tgatccaaac caacacctta cgattattca agatcctgaa     1020

tacagacggt ttggctgtac tgtagatatg aacattgcac taacgacttt cataccacat     1080

tattttactt tcccatttga agagatagac ttctccatgg aagaatctat gattcatctg     1140

ccaaataaag cttgttttct gatggcacac aatggatggg taatgggaga tgatcctctt     1200

cgaaactttg ctgaaccggg ttcagaagtt tacctaagga gagaacttat ttgctgggga     1260

gacagtgtta aattacgcta tgggaataaa ccagaggact gtccttatct ctgggcacac     1320

atgaaaaaat acactgaaat aactgcaact tatttccagg gagtacgtct tgataactgc     1380

cactcaacac ctcttcacgt agctgagtac atgttggatg ctgctaggaa tttgcaaccc     1440

aatttatatg tagtagctga actgttcaca ggaagtgagg acctagacaa tgtctttgtt     1500

actagactgg gcattagttc cttaataaga gaggcaatga gtgcatataa tagtcatgaa     1560

gagggcagat tagtttaccg atatggagga gaacctgttg gatcctttgt tcagccctgt     1620

ttgaggcctt taatgccagc tattgcacat gccctgttta tggatattac gcatgataat     1680

gagtgtccta ttgtgcatag atcagcgtat gatgctcttc caagtactac aattgtttct     1740

atggcatgtt gtgctagtgg aagtacaaga ggctatgatg aattagtgcc tcatcagatt     1800

tcagtggttt ctgaagaacg gttttacact aagtggaatc ctgaagcatt gccttcaaac     1860

acaggtgaag ttaatttcca aagcggcatt attgcagcca ggtgtgctat cagtaaactt     1920

catcaggagc ttggagccaa gggttttatt caggtgtatg tggatcaagt tgatgaagac     1980

atagtggcag taacaagaca ctcacctagc atccatcagt ctgttgtggc tgtaactaga     2040

actgctttca ggaatcccaa gacttcattt tacagcaagg aagtgcctca aatgtgcatc     2100

cctggcaaaa ttgaagaagt agttcttgaa gctagaacta ttgagagaaa cacgaaacct     2160

tataggaagg atgaaaattc aatcaatgga acaccagata tcacagtaga aattagagaa     2220

catattcagc ttaatgaaag taaaattgtt aaacaagctg gagttgccac aaaagggccc     2280

aatgaatata ttcaagaaat agaatttgaa aacttgtctc caggaagtgt tattatattc     2340

agagttagtc ttgatccaca tgcacaagtc gctgttggca ttcttcgaaa tcatctgaca     2400

caattcagtc ctcactttaa atctggcagc ctagctgttg acaatgcaga tcctatatta     2460

aaaattcctt ttgcttctct tgcctataga ttaactttgg ctgagctaaa tcagatcctt     2520

taccgatgtg aatcagaaga aaaggaagat ggtggagggt gctatgacat accaaactgg     2580

tcagccctta aatatgcagg tcttcaaggt ttaatgtctg tattggcaga aataagacca     2640

aagaatgact tggggcatcc tttttgtaat aatttgaggt ctggagattg gatgattgac     2700

tatgtcagta accggcttat ttcacgatca ggaactattg ctgaagttgg taaatggttg     2760

caggctatgt tcttctacct gaagcagatc ccacgttacc ttatcccatg ttactttgat     2820

gctatattaa ttggtgcata taccactctt ctggatacag catggaagca gatgtcaagc     2880

tttgttcaga atggttcaac ctttgtgaaa cacctttcat tgggttcagt tcaactgtgt     2940

ggagtaggaa aattcccttc cctgccaatt ctttcacctg ccctaatgga tgtaccttat     3000

aggttaaatg agatcacaaa agaaaaggag caatgttgtg tttctctagc tgcaggctta     3060

cctcattttt cttctggtat tttccgctgc tggggaaggg atacttttat tgcacttaga     3120

ggtatactgc tgattactgg acgctatgta gaagccagga atattatttt agcatttgcg     3180

ggtaccctga ggcatggtct cattcctaat ctactgggtg aaggaattta tgccagatac     3240

aattgtcggg atgctgtgtg gtggtggctg cagtgtatcc aggattactg taaaatggtt     3300

ccaaatggac tagacattct caagtgccca gtttccagaa tgtatcctac agatgattct     3360

gctcctttgc ctgctggcac actggatcag ccattgtttg aagtcataca ggaagcaatg     3420

caaaaacaca tgcagggcat acagttccga gaaaggaatg ctggtcccca gatagatcga     3480

aacatgaagg acgaaggttt taatataact gcaggagttg atgaagaaac aggatttgtt     3540

tatggaggaa atcgtttcaa ttgtggcaca tggatggata aaatgggaga aagtgacaga     3600

gctagaaaca gaggaatccc agccacacca agagatgggt ctgctgtgga aattgtgggc     3660

ctgagtaaat ctgctgttcg ctggttgctg gaattatcca aaaaaaatat tttcccttat     3720

catgaagtca cagtaaaaag acatggaaag gctataaagg tctcatatga tgagtggaac     3780

agaaaaatac aagacaactt tgaaaagcta tttcatgttt ccgaagaccc ttcagattta     3840

aatgaaaagc atccaaatct ggttcacaaa cgtggcatat acaaagatag ttatggagct     3900

tcaagtcctt ggtgtgacta tcagctcagg cctaatttta ccatagcaat ggttgtggcc     3960

cctgagctct ttactacaga aaaagcatgg aaagctttgg agattgcaga aaaaaaattg     4020

cttggtcccc ttggcatgaa aactttagat ccagatgata tggtttactg tggaatttat     4080

gacaacgcat tagacaatga caactacaat cttgctaaag gtttcaatta tcaccaagga     4140

cctgagtggc tgtggcctat tgggtatttt cttcgtgcaa aattatattt ttccagattg     4200

atgggcccgg agactactgc aaagactata gttttggtta aaaatgttct ttcccgacat     4260

tatgttcatc ttgagagatc cccttggaaa ggacttccag aactgaccaa tgagaatgcc     4320

cagtactgtc ctttcagctg tgaaacacaa gcctggtcaa ttgctactat tcttgagaca     4380

ctttatgatt tatag                                                      4395


<210>  21
<211>  4293
<212>  DNA
<213>  artificial

<220>
<223>  Nucleic acid sequence encoding D3 hGDE

<400>  21
atgggacaca gtaaacagat tcgaatttta cttctgaacg aaatggagaa actggaaaag       60

accctcttca gacttgaaca agggtatgag ctacagttcc gattaggccc aactttacag      120

ggaaaagcag ttaccgtgta tacaaattac ccatttcctg gagaaacatt taatagagaa      180

aaattccgtt ctctggattg ggaaaatcca acagaaagag aagatgattc tgataaatac      240

tgtaaactta atctgcaaca atctggttca tttcagtatt atttccttca aggaaatgag      300

aaaagtggtg gaggttacat agttgtggac cccattttac gtgttggtgc tgataatcat      360

gtgctaccct tggactgtgt tactcttcag acatttttag ctaagtgttt gggacctttt      420

gatgaatggg aaagcagact tagggttgca aaagaatcag gctacaacat gattcatttt      480

accccattgc agactcttgg actatctagg tcatgctact cccttgccaa tcagttagaa      540

ttaaatcctg acttttcaag acctaataga aagtatacct ggaatgatgt tggacagcta      600

gtggaaaaat taaaaaagga atggaatgtt atttgtatta ctgatgttgt ctacaatcat      660

actgctgcta atagtaaatg gatccaggaa catccagaat gtgcctataa tcttgtaaat      720

tctccacact taaaacctgc ctgggtctta gacagagcac tttggcgttt ctcctgtgat      780

gttgcagaag ggaaatacaa agaaaaggga atacctgctt tgattgaaaa tgatcaccat      840

atgaactcca tccgaaaaat aatttgggag gatatttttc caaagcttaa actctgggaa      900

tttttccaag tagatgtcaa caaagcggtt gagcaattta gaagacttct tacacaagaa      960

aataggcgag taaccaagtc tgatccaaac caacacctta cgattattca agatcctgaa     1020

tacagacggt ttggctgtac tgtagatatg aacattgcac taacgacttt cataccacat     1080

gacaaggggc cagcagcaat tgaagaatgc tgtaattggt ttcataaaag aatggaggaa     1140

ttaaattcag agaagcatcg actcattaac tatcatcagg aacaggcagt taattgcctt     1200

ttgggaaatg tgttttatga acgactggct ggccatggtc caaaactagg acctgtcact     1260

agaaagcatc ctttagttac caggtatttt actttcccat ttgaagagat agacttctcc     1320

atggaagaat ctatgattca tctgccaaat aaagcttgtt ttctgatggc acacaatgga     1380

tgggtaatgg gagatgatcc tcttcgaaac tttgctgaac cgggttcaga agtttaccta     1440

aggagagaac ttatttgctg gggagacagt gttaaattac gctatgggaa taaaccagag     1500

gactgtcctt atctctgggc acacatgaaa aaatacactg aaataactgc aacttatttc     1560

cagggagtac gtcttgataa ctgccactca acacctcttc acgtagctga gtacatgttg     1620

gatgctgcta ggaatttgca acccaattta tatgtagtag ctgaactgtt cacaggaagt     1680

gaggacctag acaatgtctt tgttactaga ctgggcatta gttccttaat aagagaggca     1740

atgagtgcat ataatagtca tgaagagggc agattagttt accgatatgg aggagaacct     1800

gttggatcct ttgttcagcc ctgtttgagg cctttaatgc cagctattgc acatgccctg     1860

tttatggata ttacgcatga taatgagtgt cctattgtgc atagatcagc gtatgatgct     1920

cttccaagta ctacaattgt ttctatggca tgttgtgcta gtggaagtac aagaggctat     1980

gatgaattag tgcctcatca gggcaaaatt gaagaagtag ttcttgaagc tagaactatt     2040

gagagaaaca cgaaacctta taggaaggat gaaaattcaa tcaatggaac accagatatc     2100

acagtagaaa ttagagaaca tattcagctt aatgaaagta aaattgttaa acaagctgga     2160

gttgccacaa aagggcccaa tgaatatatt caagaaatag aatttgaaaa cttgtctcca     2220

ggaagtgtta ttatattcag agttagtctt gatccacatg cacaagtcgc tgttggcatt     2280

cttcgaaatc atctgacaca attcagtcct cactttaaat ctggcagcct agctgttgac     2340

aatgcagatc ctatattaaa aattcctttt gcttctcttg cctatagatt aactttggct     2400

gagctaaatc agatccttta ccgatgtgaa tcagaagaaa aggaagatgg tggagggtgc     2460

tatgacatac caaactggtc agcccttaaa tatgcaggtc ttcaaggttt aatgtctgta     2520

ttggcagaaa taagaccaaa gaatgacttg gggcatcctt tttgtaataa tttgaggtct     2580

ggagattgga tgattgacta tgtcagtaac cggcttattt cacgatcagg aactattgct     2640

gaagttggta aatggttgca ggctatgttc ttctacctga agcagatccc acgttacctt     2700

atcccatgtt actttgatgc tatattaatt ggtgcatata ccactcttct ggatacagca     2760

tggaagcaga tgtcaagctt tgttcagaat ggttcaacct ttgtgaaaca cctttcattg     2820

ggttcagttc aactgtgtgg agtaggaaaa ttcccttccc tgccaattct ttcacctgcc     2880

ctaatggatg taccttatag gttaaatgag atcacaaaag aaaaggagca atgttgtgtt     2940

tctctagctg caggcttacc tcatttttct tctggtattt tccgctgctg gggaagggat     3000

acttttattg cacttagagg tatactgctg attactggac gctatgtaga agccaggaat     3060

attattttag catttgcggg taccctgagg catggtctca ttcctaatct actgggtgaa     3120

ggaatttatg ccagatacaa ttgtcgggat gctgtgtggt ggtggctgca gtgtatccag     3180

gattactgta aaatggttcc aaatggacta gacattctca agtgcccagt ttccagaatg     3240

tatcctacag atgattctgc tcctttgcct gctggcacac tggatcagcc attgtttgaa     3300

gtcatacagg aagcaatgca aaaacacatg cagggcatac agttccgaga aaggaatgct     3360

ggtccccaga tagatcgaaa catgaaggac gaaggtttta atataactgc aggagttgat     3420

gaagaaacag gatttgttta tggaggaaat cgtttcaatt gtggcacatg gatggataaa     3480

atgggagaaa gtgacagagc tagaaacaga ggaatcccag ccacaccaag agatgggtct     3540

gctgtggaaa ttgtgggcct gagtaaatct gctgttcgct ggttgctgga attatccaaa     3600

aaaaatattt tcccttatca tgaagtcaca gtaaaaagac atggaaaggc tataaaggtc     3660

tcatatgatg agtggaacag aaaaatacaa gacaactttg aaaagctatt tcatgtttcc     3720

gaagaccctt cagatttaaa tgaaaagcat ccaaatctgg ttcacaaacg tggcatatac     3780

aaagatagtt atggagcttc aagtccttgg tgtgactatc agctcaggcc taattttacc     3840

atagcaatgg ttgtggcccc tgagctcttt actacagaaa aagcatggaa agctttggag     3900

attgcagaaa aaaaattgct tggtcccctt ggcatgaaaa ctttagatcc agatgatatg     3960

gtttactgtg gaatttatga caacgcatta gacaatgaca actacaatct tgctaaaggt     4020

ttcaattatc accaaggacc tgagtggctg tggcctattg ggtattttct tcgtgcaaaa     4080

ttatattttt ccagattgat gggcccggag actactgcaa agactatagt tttggttaaa     4140

aatgttcttt cccgacatta tgttcatctt gagagatccc cttggaaagg acttccagaa     4200

ctgaccaatg agaatgccca gtactgtcct ttcagctgtg aaacacaagc ctggtcaatt     4260

gctactattc ttgagacact ttatgattta tag                                  4293


<210>  22
<211>  4089
<212>  DNA
<213>  artificial

<220>
<223>  Nucleic acid sequence encoding D2,3 hGDE WT

<400>  22
atgggacaca gtaaacagat tcgaatttta cttctgaacg aaatggagaa actggaaaag       60

accctcttca gacttgaaca agggtatgag ctacagttcc gattaggccc aactttacag      120

ggaaaagcag ttaccgtgta tacaaattac ccatttcctg gagaaacatt taatagagaa      180

aaattccgtt ctctggattg ggaaaatcca acagaaagag aagatgattc tgataaatac      240

tgtaaactta atctgcaaca atctggttca tttcagtatt atttccttca aggaaatgag      300

aaaagtggtg gaggttacat agttgtggac cccattttac gtgttggtgc tgataatcat      360

gtgctaccct tggactgtgt tactcttcag acatttttag ctaagtgttt gggacctttt      420

gatgaatggg aaagcagact tagggttgca aaagaatcag gctacaacat gattcatttt      480

accccattgc agactcttgg actatctagg tcatgctact cccttgccaa tcagttagaa      540

ttaaatcctg acttttcaag acctaataga aagtatacct ggaatgatgt tggacagcta      600

gtggaaaaat taaaaaagga atggaatgtt atttgtatta ctgatgttgt ctacaatcat      660

actgctgcta atagtaaatg gatccaggaa catccagaat gtgcctataa tcttgtaaat      720

tctccacact taaaacctgc ctgggtctta gacagagcac tttggcgttt ctcctgtgat      780

gttgcagaag ggaaatacaa agaaaaggga atacctgctt tgattgaaaa tgatcaccat      840

atgaactcca tccgaaaaat aatttgggag gatatttttc caaagcttaa actctgggaa      900

tttttccaag tagatgtcaa caaagcggtt gagcaattta gaagacttct tacacaagaa      960

aataggcgag taaccaagtc tgatccaaac caacacctta cgattattca agatcctgaa     1020

tacagacggt ttggctgtac tgtagatatg aacattgcac taacgacttt cataccacat     1080

tattttactt tcccatttga agagatagac ttctccatgg aagaatctat gattcatctg     1140

ccaaataaag cttgttttct gatggcacac aatggatggg taatgggaga tgatcctctt     1200

cgaaactttg ctgaaccggg ttcagaagtt tacctaagga gagaacttat ttgctgggga     1260

gacagtgtta aattacgcta tgggaataaa ccagaggact gtccttatct ctgggcacac     1320

atgaaaaaat acactgaaat aactgcaact tatttccagg gagtacgtct tgataactgc     1380

cactcaacac ctcttcacgt agctgagtac atgttggatg ctgctaggaa tttgcaaccc     1440

aatttatatg tagtagctga actgttcaca ggaagtgagg acctagacaa tgtctttgtt     1500

actagactgg gcattagttc cttaataaga gaggcaatga gtgcatataa tagtcatgaa     1560

gagggcagat tagtttaccg atatggagga gaacctgttg gatcctttgt tcagccctgt     1620

ttgaggcctt taatgccagc tattgcacat gccctgttta tggatattac gcatgataat     1680

gagtgtccta ttgtgcatag atcagcgtat gatgctcttc caagtactac aattgtttct     1740

atggcatgtt gtgctagtgg aagtacaaga ggctatgatg aattagtgcc tcatcagggc     1800

aaaattgaag aagtagttct tgaagctaga actattgaga gaaacacgaa accttatagg     1860

aaggatgaaa attcaatcaa tggaacacca gatatcacag tagaaattag agaacatatt     1920

cagcttaatg aaagtaaaat tgttaaacaa gctggagttg ccacaaaagg gcccaatgaa     1980

tatattcaag aaatagaatt tgaaaacttg tctccaggaa gtgttattat attcagagtt     2040

agtcttgatc cacatgcaca agtcgctgtt ggcattcttc gaaatcatct gacacaattc     2100

agtcctcact ttaaatctgg cagcctagct gttgacaatg cagatcctat attaaaaatt     2160

ccttttgctt ctcttgccta tagattaact ttggctgagc taaatcagat cctttaccga     2220

tgtgaatcag aagaaaagga agatggtgga gggtgctatg acataccaaa ctggtcagcc     2280

cttaaatatg caggtcttca aggtttaatg tctgtattgg cagaaataag accaaagaat     2340

gacttggggc atcctttttg taataatttg aggtctggag attggatgat tgactatgtc     2400

agtaaccggc ttatttcacg atcaggaact attgctgaag ttggtaaatg gttgcaggct     2460

atgttcttct acctgaagca gatcccacgt taccttatcc catgttactt tgatgctata     2520

ttaattggtg catataccac tcttctggat acagcatgga agcagatgtc aagctttgtt     2580

cagaatggtt caacctttgt gaaacacctt tcattgggtt cagttcaact gtgtggagta     2640

ggaaaattcc cttccctgcc aattctttca cctgccctaa tggatgtacc ttataggtta     2700

aatgagatca caaaagaaaa ggagcaatgt tgtgtttctc tagctgcagg cttacctcat     2760

ttttcttctg gtattttccg ctgctgggga agggatactt ttattgcact tagaggtata     2820

ctgctgatta ctggacgcta tgtagaagcc aggaatatta ttttagcatt tgcgggtacc     2880

ctgaggcatg gtctcattcc taatctactg ggtgaaggaa tttatgccag atacaattgt     2940

cgggatgctg tgtggtggtg gctgcagtgt atccaggatt actgtaaaat ggttccaaat     3000

ggactagaca ttctcaagtg cccagtttcc agaatgtatc ctacagatga ttctgctcct     3060

ttgcctgctg gcacactgga tcagccattg tttgaagtca tacaggaagc aatgcaaaaa     3120

cacatgcagg gcatacagtt ccgagaaagg aatgctggtc cccagataga tcgaaacatg     3180

aaggacgaag gttttaatat aactgcagga gttgatgaag aaacaggatt tgtttatgga     3240

ggaaatcgtt tcaattgtgg cacatggatg gataaaatgg gagaaagtga cagagctaga     3300

aacagaggaa tcccagccac accaagagat gggtctgctg tggaaattgt gggcctgagt     3360

aaatctgctg ttcgctggtt gctggaatta tccaaaaaaa atattttccc ttatcatgaa     3420

gtcacagtaa aaagacatgg aaaggctata aaggtctcat atgatgagtg gaacagaaaa     3480

atacaagaca actttgaaaa gctatttcat gtttccgaag acccttcaga tttaaatgaa     3540

aagcatccaa atctggttca caaacgtggc atatacaaag atagttatgg agcttcaagt     3600

ccttggtgtg actatcagct caggcctaat tttaccatag caatggttgt ggcccctgag     3660

ctctttacta cagaaaaagc atggaaagct ttggagattg cagaaaaaaa attgcttggt     3720

ccccttggca tgaaaacttt agatccagat gatatggttt actgtggaat ttatgacaac     3780

gcattagaca atgacaacta caatcttgct aaaggtttca attatcacca aggacctgag     3840

tggctgtggc ctattgggta ttttcttcgt gcaaaattat atttttccag attgatgggc     3900

ccggagacta ctgcaaagac tatagttttg gttaaaaatg ttctttcccg acattatgtt     3960

catcttgaga gatccccttg gaaaggactt ccagaactga ccaatgagaa tgcccagtac     4020

tgtcctttca gctgtgaaac acaagcctgg tcaattgcta ctattcttga gacactttat     4080

gatttatag                                                             4089


<210>  23
<211>  4089
<212>  DNA
<213>  artificial

<220>
<223>  Nucleic acid sequence encoding D2,3 hGDE co2

<400>  23
atgggccaca gcaagcagat cagaatcctg ctgctgaacg agatggaaaa gctggaaaag       60

accctgttcc ggctcgagca gggctacgag ctgcagttta gactgggccc tacactgcag      120

ggcaaagccg tgaccgtgta cacaaactac cccttccctg gcgaaacctt caaccgcgag      180

aagttcagaa gcctggactg ggagaacccc accgagagag aggacgacag cgacaagtac      240

tgcaagctga acctgcagca gagcggctcc ttccagtact acttcctgca aggcaacgag      300

aagtccggcg gaggctacat cgtggtggac cctattctga gagtgggcgc cgacaatcac      360

gtgctgcctc tggattgtgt gaccctgcag accttcctgg ccaagtgtct gggccctttc      420

gatgagtggg agagcagact gcgcgtggcc aaagaaagcg gctacaacat gatccacttc      480

acccctctgc agaccctggg cctgagcaga agctgttaca gcctggccaa ccagctggaa      540

ctgaaccccg acttcagcag acccaaccgg aagtacacct ggaacgatgt gggccagctg      600

gtggaaaaac tgaagaaaga atggaacgtg atctgcatca ccgacgtggt gtacaaccac      660

accgccgcca acagcaagtg gatccaagag caccctgagt gcgcctacaa cctggtcaac      720

agccctcacc tgaaacctgc ctgggtgctc gatagagccc tgtggcggtt tagctgtgat      780

gtggccgagg gcaagtacaa agagaagggc atccccgctc tgatcgagaa cgaccaccac      840

atgaacagca tccggaagat catctgggaa gatattttcc ccaagctgaa gctgtgggag      900

ttcttccagg tggacgtgaa caaggccgtg gaacagttca gacggctgct gacccaagag      960

aacagaagag tgaccaagag cgaccccaac cagcacctga ccatcattca ggaccccgag     1020

tatcggagat tcggctgcac cgtggacatg aatatcgccc tgaccacctt cattccccac     1080

tacttcacct ttccattcga agagatcgac ttctccatgg aagagagcat gatccatctg     1140

cctaacaagg cctgcttcct gatggctcac aacggctggg ttatgggcga cgaccctctg     1200

agaaatttcg ccgagcctgg cagcgaggtg tacctgagaa gagaactgat ctgttggggc     1260

gacagcgtga agctgagata cggcaacaag cccgaggact gcccttacct gtgggcccat     1320

atgaagaagt acacagagat caccgccacc tactttcagg gcgtcagact ggacaactgc     1380

cacagcacac ctctgcacgt ggccgagtac atgctggacg ccgctagaaa tctgcagccc     1440

aacctgtatg tggtggccga gctgtttacc ggctccgagg acctggacaa tgtgttcgtg     1500

accagactgg gcatcagcag cctgatcaga gaagccatgt ccgcctacaa tagccacgaa     1560

gagggcagac tggtgtacag atatggcggc gagcctgtgg gcagcttcgt tcagccttgt     1620

ctgaggcctc tgatgcccgc cattgctcac gccctgttca tggacatcac ccacgataac     1680

gagtgcccca tcgtgcacag aagcgcctac gacgctctgc ctagcaccac cattgtgtcc     1740

atggcctgtt gtgccagcgg cagcacaaga ggctatgacg aactggtgcc ccaccagggc     1800

aagattgagg aagtggtgct cgaggcccgg accatcgaga gaaacaccaa gccttaccgg     1860

aaggacgaga actccatcaa cggcacccct gacatcaccg tggaaatcag agagcacatc     1920

cagctcaacg agagcaagat cgtgaaacag gccggcgtgg ccacaaaggg ccccaacgag     1980

tatatccaag agattgagtt cgagaatctg agccccggca gcgtgatcat cttcagagtg     2040

tccctggatc ctcacgctca ggtggccgtg ggcatcctga gaaatcacct gacacagttc     2100

agcccacact tcaagagcgg aagcctggcc gtggacaacg ccgatcctat cctgaagatc     2160

cccttcgcct ctctggccta cagactgaca ctggctgagc tgaaccagat cctgtacaga     2220

tgcgagtccg aagagaaaga ggatggcgga ggctgctacg acatccccaa ttggagcgcc     2280

ctgaagtatg ccggactgca gggactgatg tctgtgctgg ccgagatcag acccaagaac     2340

gacctgggac accccttctg caacaacctg agatccggcg actggatgat cgactacgtg     2400

tccaacagac tgatcagcag atccggcaca atcgccgaag tcggcaaatg gctgcaggcc     2460

atgttcttct acctgaagca gatccctcgg tatctgatcc cctgctactt cgacgccatc     2520

ctgatcggcg cctacaccac actgctggat accgcctgga agcagatgtc cagcttcgtg     2580

cagaacggca gcaccttcgt gaagcacctg tctctgggaa gcgtgcagct gtgtggcgtg     2640

ggcaaatttc ccagcctgcc tatcctgtct cctgcactga tggacgtgcc ctaccggctg     2700

aatgagatca ccaaagaaaa agagcagtgc tgcgtcagcc tggctgctgg cctgcctcat     2760

ttttccagcg gcatcttccg gtgttggggc agagacacct ttattgccct gagaggcatc     2820

ctgctgatta ccggcagata cgtggaagcc cggaacatca tcctggcctt tgccggcaca     2880

ctgcggcacg gactgattcc taatctgctc ggcgagggca tctacgccag atacaactgc     2940

agagatgccg tgtggtggtg gctccagtgc atccaggact actgcaagat ggtgcccaac     3000

ggcctggaca tcctgaagtg ccctgtgtcc agaatgtacc ctaccgacga tagcgcccct     3060

ctgcctgccg gaacacttga ccagcctctg ttcgaagtga ttcaagaggc catgcagaaa     3120

cacatgcagg gaatccagtt tcgcgagcgg aatgccggac ctcagatcga cagaaacatg     3180

aaggatgagg gcttcaacat caccgctggc gtggacgaag agacaggctt tgtgtacggc     3240

ggcaaccggt tcaattgcgg cacctggatg gacaagatgg gcgagtctga ccgggccaga     3300

aacagaggaa ttcccgccac acctagagat ggcagcgctg tggaaatcgt gggcctgtct     3360

aagtctgctg tgcggtggct gctcgaactg agcaagaaga atatctttcc gtaccacgaa     3420

gtgaccgtga agcggcacgg caaggccatc aaggtgtcct acgacgagtg gaacagaaag     3480

atccaggaca acttcgaaaa gctgttccat gtgtctgagg accccagcga cctgaacgaa     3540

aagcacccca acctggtgca caagcgcggc atctacaagg acagctacgg cgcctcttct     3600

ccttggtgcg attaccagct gcggcccaac ttcaccattg ccatggtggt tgcccctgag     3660

ctgttcacca cagagaaggc ctggaaggcc ctggaaatcg ccgagaagaa actgctgggc     3720

cctctgggca tgaagacact ggaccccgac gacatggtgt actgcggaat ctacgacaac     3780

gccctggata acgacaacta caatctggcc aaggggttca attaccatca gggacccgag     3840

tggctgtggc ctatcggcta tttcctgcgg gccaagctgt acttctccag actgatgggc     3900

cctgagacaa ccgccaagac aatcgtgctc gtgaagaacg tgctgagccg gcactatgtg     3960

cacctggaaa gaagcccctg gaagggactg cccgagctga ccaatgagaa cgcccagtac     4020

tgccccttca gctgcgaaac acaggcctgg tctatcgcca ccatcctgga aaccctgtac     4080

gacctgtga                                                             4089


<210>  24
<211>  4020
<212>  DNA
<213>  artificial

<220>
<223>  Nucleic acid sequence encoding D4 hGDE WT

<400>  24
atgggacaca gtaaacagat tcgaatttta cttctgaacg aaatggagaa actggaaaag       60

accctcttca gacttgaaca agggtatgag ctacagttcc gattaggccc aactttacag      120

ggaaaagcag ttaccgtgta tacaaattac ccatttcctg gagaaacatt taatagagaa      180

aaattccgtt ctctggattg ggaaaatcca acagaaagag aagatgattc tgataaatac      240

tgtaaactta atctgcaaca atctggttca tttcagtatt atttccttca aggaaatgag      300

aaaagtggtg gaggttacat agttgtggac cccattttac gtgttggtgc tgataatcat      360

gtgctaccct tggactgtgt tactcttcag acatttttag ctaagtgttt gggacctttt      420

gatgaatggg aaagcagact tagggttgca aaagaatcag gctacaacat gattcatttt      480

accccattgc agactcttgg actatctagg tcatgctact cccttgccaa tcagttagaa      540

ttaaatcctg acttttcaag acctaataga aagtatacct ggaatgatgt tggacagcta      600

gtggaaaaat taaaaaagga atggaatgtt atttgtatta ctgatgttgt ctacaatcat      660

actgctgcta atagtaaatg gatccaggaa catccagaat gtgcctataa tcttgtaaat      720

tctccacact taaaacctgc ctgggtctta gacagagcac tttggcgttt ctcctgtgat      780

gttgcagaag ggaaatacaa agaaaaggga atacctgctt tgattgaaaa tgatcaccat      840

atgaactcca tccgaaaaat aatttgggag gatatttttc caaagcttaa actctgggaa      900

tttttccaag tagatgtcaa caaagcggtt gagcaattta gaagacttct tacacaagaa      960

aataggcgag taaccaagtc tgatccaaac caacacctta cgattattca agatcctgaa     1020

tacagacggt ttggctgtac tgtagatatg aacattgcac taacgacttt cataccacat     1080

gacaaggggc cagcagcaat tgaagaatgc tgtaattggt ttcataaaag aatggaggaa     1140

ttaaattcag agaagcatcg actcattaac tatcatcagg aacaggcagt taattgcctt     1200

ttgggaaatg tgttttatga acgactggct ggccatggtc caaaactagg acctgtcact     1260

agaaagcatc ctttagttac caggtatttt actttcccat ttgaagagat agacttctcc     1320

atggaagaat ctatgattca tctgccaaat aaagcttgtt ttctgatggc acacaatgga     1380

tgggtaatgg gagatgatcc tcttcgaaac tttgctgaac cgggttcaga agtttaccta     1440

aggagagaac ttatttgctg gggagacagt gttaaattac gctatgggaa taaaccagag     1500

gactgtcctt atctctgggc acacatgaaa aaatacactg aaataactgc aacttatttc     1560

cagggagtac gtcttgataa ctgccactca acacctcttc acgtagctga gtacatgttg     1620

gatgctgcta ggaatttgca acccaattta tatgtagtag ctgaactgtt cacaggaagt     1680

gaggacctag acaatgtctt tgttactaga ctgggcatta gttccttaat aagagaggca     1740

atgagtgcat ataatagtca tgaagagggc agattagttt accgatatgg aggagaacct     1800

gttggatcct ttgttcagcc ctgtttgagg cctttaatgc cagctattgc acatgccctg     1860

tttatggata ttacgcatga taatgagtgt cctattgtgc atagatcagc gtatgatgct     1920

cttccaagta ctacaattgt ttctatggca tgttgtgcta gtggaagtac aagaggctat     1980

gatgaattag tgcctcatca gatttcagtg gtttctgaag aacggtttta cactaagtgg     2040

aatcctgaag cattgccttc aaacacaggt gaagttaatt tccaaagcgg cattattgca     2100

gccaggtgtg ctatcagtaa acttcatcag gagcttggag ccaagggttt tattcaggtg     2160

tatgtggatc aagttgatga agacatagtg gcagtaacaa gacactcacc tagcatccat     2220

cagtctgttg tggctgtaac tagaactgct ttcaggaatc ccaagacttc attttacagc     2280

aaggaagtgc ctcaaatgtg catccctggc aaaattgaag aagtagttct tgaagctaga     2340

actattgaga gaaacacgaa accttatagg aaggatgaaa attcaatcaa tggaacacca     2400

gatatcacag tagaaattag agaacatatt cagcttaatg aaagtaaaat tgttaaacaa     2460

gctggagttg ccacaaaagg gcccaatgaa tatattcaag aaatagaatt tgaaaacttg     2520

tctccaggaa gtgttattat attcagagtt agtcttgatc cacatgcaca agtcgctgtt     2580

ggcattcttc gaaatcatct gacacaattc agtcctcact ttaaatctgg cagcctagct     2640

gttgacaatg cagatcctat attaaaaatt ccttttgctt ctttacctca tttttcttct     2700

ggtattttcc gctgctgggg aagggatact tttattgcac ttagaggtat actgctgatt     2760

actggacgct atgtagaagc caggaatatt attttagcat ttgcgggtac cctgaggcat     2820

ggtctcattc ctaatctact gggtgaagga atttatgcca gatacaattg tcgggatgct     2880

gtgtggtggt ggctgcagtg tatccaggat tactgtaaaa tggttccaaa tggactagac     2940

attctcaagt gcccagtttc cagaatgtat cctacagatg attctgctcc tttgcctgct     3000

ggcacactgg atcagccatt gtttgaagtc atacaggaag caatgcaaaa acacatgcag     3060

ggcatacagt tccgagaaag gaatgctggt ccccagatag atcgaaacat gaaggacgaa     3120

ggttttaata taactgcagg agttgatgaa gaaacaggat ttgtttatgg aggaaatcgt     3180

ttcaattgtg gcacatggat ggataaaatg ggagaaagtg acagagctag aaacagagga     3240

atcccagcca caccaagaga tgggtctgct gtggaaattg tgggcctgag taaatctgct     3300

gttcgctggt tgctggaatt atccaaaaaa aatattttcc cttatcatga agtcacagta     3360

aaaagacatg gaaaggctat aaaggtctca tatgatgagt ggaacagaaa aatacaagac     3420

aactttgaaa agctatttca tgtttccgaa gacccttcag atttaaatga aaagcatcca     3480

aatctggttc acaaacgtgg catatacaaa gatagttatg gagcttcaag tccttggtgt     3540

gactatcagc tcaggcctaa ttttaccata gcaatggttg tggcccctga gctctttact     3600

acagaaaaag catggaaagc tttggagatt gcagaaaaaa aattgcttgg tccccttggc     3660

atgaaaactt tagatccaga tgatatggtt tactgtggaa tttatgacaa cgcattagac     3720

aatgacaact acaatcttgc taaaggtttc aattatcacc aaggacctga gtggctgtgg     3780

cctattgggt attttcttcg tgcaaaatta tatttttcca gattgatggg cccggagact     3840

actgcaaaga ctatagtttt ggttaaaaat gttctttccc gacattatgt tcatcttgag     3900

agatcccctt ggaaaggact tccagaactg accaatgaga atgcccagta ctgtcctttc     3960

agctgtgaaa cacaagcctg gtcaattgct actattcttg agacacttta tgatttatag     4020


<210>  25
<211>  4020
<212>  DNA
<213>  artificial

<220>
<223>  Nucleic acid sequence encoding D4 hGDE co2

<400>  25
atgggccaca gcaagcagat cagaatcctg ctgctgaacg agatggaaaa gctggaaaag       60

accctgttcc ggctcgagca gggctacgag ctgcagttta gactgggccc tacactgcag      120

ggcaaagccg tgaccgtgta cacaaactac cccttccctg gcgaaacctt caaccgcgag      180

aagttcagaa gcctggactg ggagaacccc accgagagag aggacgacag cgacaagtac      240

tgcaagctga acctgcagca gagcggctcc ttccagtact acttcctgca aggcaacgag      300

aagtccggcg gaggctacat cgtggtggac cctattctga gagtgggcgc cgacaatcac      360

gtgctgcctc tggattgtgt gaccctgcag accttcctgg ccaagtgtct gggccctttc      420

gatgagtggg agagcagact gcgcgtggcc aaagaaagcg gctacaacat gatccacttc      480

acccctctgc agaccctggg cctgagcaga agctgttaca gcctggccaa ccagctggaa      540

ctgaaccccg acttcagcag acccaaccgg aagtacacct ggaacgatgt gggccagctg      600

gtggaaaaac tgaagaaaga atggaacgtg atctgcatca ccgacgtggt gtacaaccac      660

accgccgcca acagcaagtg gatccaagag caccctgagt gcgcctacaa cctggtcaac      720

agccctcacc tgaaacctgc ctgggtgctc gatagagccc tgtggcggtt tagctgtgat      780

gtggccgagg gcaagtacaa agagaagggc atccccgctc tgatcgagaa cgaccaccac      840

atgaacagca tccggaagat catctgggaa gatattttcc ccaagctgaa gctgtgggag      900

ttcttccagg tggacgtgaa caaggccgtg gaacagttca gacggctgct gacccaagag      960

aacagaagag tgaccaagag cgaccccaac cagcacctga ccatcattca ggaccccgag     1020

tatcggagat tcggctgcac cgtggacatg aatatcgccc tgaccacctt cattccccac     1080

gacaaaggac ctgccgccat cgaggaatgc tgcaactggt tccacaagcg gatggaagaa     1140

ttgaacagcg agaagcaccg gctgatcaac taccaccaag agcaggccgt gaactgcctg     1200

ctgggcaacg tgttctatga gagactggcc ggacacggcc ctaagctggg acctgtgaca     1260

agaaagcacc ctctggttac ccggtacttc acctttccat tcgaagagat cgacttctcc     1320

atggaagaga gcatgatcca tctgcctaac aaggcctgct tcctgatggc tcacaacggc     1380

tgggttatgg gcgacgaccc tctgagaaat ttcgccgagc ctggcagcga ggtgtacctg     1440

agaagagaac tgatctgttg gggcgacagc gtgaagctga gatacggcaa caagcccgag     1500

gactgccctt acctgtgggc ccatatgaag aagtacacag agatcaccgc cacctacttt     1560

cagggcgtca gactggacaa ctgccacagc acacctctgc acgtggccga gtacatgctg     1620

gacgccgcta gaaatctgca gcccaacctg tatgtggtgg ccgagctgtt taccggctcc     1680

gaggacctgg acaatgtgtt cgtgaccaga ctgggcatca gcagcctgat cagagaagcc     1740

atgtccgcct acaatagcca cgaagagggc agactggtgt acagatatgg cggcgagcct     1800

gtgggcagct tcgttcagcc ttgtctgagg cctctgatgc ccgccattgc tcacgccctg     1860

ttcatggaca tcacccacga taacgagtgc cccatcgtgc acagaagcgc ctacgacgct     1920

ctgcctagca ccaccattgt gtccatggcc tgttgtgcca gcggcagcac aagaggctat     1980

gacgaactgg tgccccacca gatttccgtg gtgtccgagg aacggttcta caccaagtgg     2040

aaccccgagg ctctgcccag caataccggc gaagtgaatt tccagagcgg catcattgcc     2100

gccagatgcg ccatcagcaa gctgcaccaa gaactgggcg ccaagggctt cattcaggtg     2160

tacgtggacc aggtcgacga ggacattgtg gccgtgacaa gacacagccc cagcatccat     2220

cagagcgtgg tggctgtgac cagaaccgcc ttcagaaacc ccaagaccag cttctacagc     2280

aaagaggtgc cccagatgtg catccccggc aagattgagg aagtggtgct cgaggcccgg     2340

accatcgaga gaaacaccaa gccttaccgg aaggacgaga actccatcaa cggcacccct     2400

gacatcaccg tggaaatcag agagcacatc cagctcaacg agagcaagat cgtgaaacag     2460

gccggcgtgg ccacaaaggg ccccaacgag tatatccaag agattgagtt cgagaatctg     2520

agccccggca gcgtgatcat cttcagagtg tccctggatc ctcacgctca ggtggccgtg     2580

ggcatcctga gaaatcacct gacacagttc agcccacact tcaagagcgg aagcctggcc     2640

gtggacaacg ccgatcctat cctgaagatc cccttcgcct ctctgcctca tttttccagc     2700

ggcatcttcc ggtgttgggg cagagacacc tttattgccc tgagaggcat cctgctgatt     2760

accggcagat acgtggaagc ccggaacatc atcctggcct ttgccggcac actgcggcac     2820

ggactgattc ctaatctgct cggcgagggc atctacgcca gatacaactg cagagatgcc     2880

gtgtggtggt ggctccagtg catccaggac tactgcaaga tggtgcccaa cggcctggac     2940

atcctgaagt gccctgtgtc cagaatgtac cctaccgacg atagcgcccc tctgcctgcc     3000

ggaacacttg accagcctct gttcgaagtg attcaagagg ccatgcagaa acacatgcag     3060

ggaatccagt ttcgcgagcg gaatgccgga cctcagatcg acagaaacat gaaggatgag     3120

ggcttcaaca tcaccgctgg cgtggacgaa gagacaggct ttgtgtacgg cggcaaccgg     3180

ttcaattgcg gcacctggat ggacaagatg ggcgagtctg accgggccag aaacagagga     3240

attcccgcca cacctagaga tggcagcgct gtggaaatcg tgggcctgtc taagtctgct     3300

gtgcggtggc tgctcgaact gagcaagaag aatatctttc cgtaccacga agtgaccgtg     3360

aagcggcacg gcaaggccat caaggtgtcc tacgacgagt ggaacagaaa gatccaggac     3420

aacttcgaaa agctgttcca tgtgtctgag gaccccagcg acctgaacga aaagcacccc     3480

aacctggtgc acaagcgcgg catctacaag gacagctacg gcgcctcttc tccttggtgc     3540

gattaccagc tgcggcccaa cttcaccatt gccatggtgg ttgcccctga gctgttcacc     3600

acagagaagg cctggaaggc cctggaaatc gccgagaaga aactgctggg ccctctgggc     3660

atgaagacac tggaccccga cgacatggtg tactgcggaa tctacgacaa cgccctggat     3720

aacgacaact acaatctggc caaggggttc aattaccatc agggacccga gtggctgtgg     3780

cctatcggct atttcctgcg ggccaagctg tacttctcca gactgatggg ccctgagaca     3840

accgccaaga caatcgtgct cgtgaagaac gtgctgagcc ggcactatgt gcacctggaa     3900

agaagcccct ggaagggact gcccgagctg accaatgaga acgcccagta ctgccccttc     3960

agctgcgaaa cacaggcctg gtctatcgcc accatcctgg aaaccctgta cgacctgtga     4020


<210>  26
<211>  3942
<212>  DNA
<213>  artificial

<220>
<223>  Nucleic acid sequence encoding D5 hGDE

<400>  26
atgggacaca gtaaacagat tcgaatttta cttctgaacg aaatggagaa actggaaaag       60

accctcttca gacttgaaca agggtatgag ctacagttcc gattaggccc aactttacag      120

ggaaaagcag ttaccgtgta tacaaattac ccatttcctg gagaaacatt taatagagaa      180

aaattccgtt ctctggattg ggaaaatcca acagaaagag aagatgattc tgataaatac      240

tgtaaactta atctgcaaca atctggttca tttcagtatt atttccttca aggaaatgag      300

aaaagtggtg gaggttacat agttgtggac cccattttac gtgttggtgc tgataatcat      360

gtgctaccct tggactgtgt tactcttcag acatttttag ctaagtgttt gggacctttt      420

gatgaatggg aaagcagact tagggttgca aaagaatcag gctacaacat gattcatttt      480

accccattgc agactcttgg actatctagg tcatgctact cccttgccaa tcagttagaa      540

ttaaatcctg acttttcaag acctaataga aagtatacct ggaatgatgt tggacagcta      600

gtggaaaaat taaaaaagga atggaatgtt atttgtatta ctgatgttgt ctacaatcat      660

actgctaata ggcgagtaac caagtctgat ccaaaccaac accttacgat tattcaagat      720

cctgaataca gacggtttgg ctgtactgta gatatgaaca ttgcactaac gactttcata      780

ccatatttta ctttcccatt tgaagagata gacttctcca tggaagaatc tatgattcat      840

ctgccaaata aagcttgttt tctgatggca cacaatggat gggtaatggg agatgatcct      900

cttcgaaact ttgctgaacc gggttcagaa gtttacctaa ggagagaact tatttgctgg      960

ggagacagtg ttaaattacg ctatgggaat aaaccagagg actgtcctta tctctgggca     1020

cacatgaaaa aatacactga aataactgca acttatttcc agggagtacg tcttgataac     1080

tgccactcaa cacctcttca cgtagctgag tacatgttgg atgctgctag gaatttgcaa     1140

cccaatttat atgtagtagc tgaactgttc acaggaagtg aggacctaga caatgtcttt     1200

gttactagac tgggcattag ttccttaata agagaggcaa tgagtgcata taatagtcat     1260

gaagagggca gattagttta ccgatatgga ggagaacctg ttggatcctt tgttcagccc     1320

tgtttgaggc ctttaatgcc agctattgca catgccctgt ttatggatat tacgcatgat     1380

aatgagtgtc ctattgtgca tagatcagcg tatgatgctc ttccaagtac tacaattgtt     1440

tctatggcat gttgtgctag tggaagtaca agaggctatg atgaattagt gcctcatcag     1500

atttatgtgg atcaagttga tgaagacata gtggcagtaa caagacactc acctagcatc     1560

catcagtctg ttgtggctgt aactagaact gctttcagga atcccaagac ttcattttac     1620

agcaaggaag tgcctcaaat gtgcatccct ggcaaaattg aagaagtagt tcttgaagct     1680

agaactattg agagaaacac gaaaccttat aggaaggatg aaaattcaat caatggaaca     1740

ccagatatca cagtagaaat tagagaacat attcagctta atgaaagtaa aattgttaaa     1800

caagctggag ttgccacaaa agggcccaat gaatatattc aagaaataga atttgaaaac     1860

ttgtctccag gaagtgttat tatattcaga gttagtcttg atccacatgc acaagtcgct     1920

gttggcattc ttcgaaatca tctgacacaa ttcagtcctc actttaaatc tggcagccta     1980

gctgttgaca atgcagatcc tatattaaaa attccttttg cttctcttgc ctatagatta     2040

actttggctg agctaaatca gatcctttac cgatgtgaat cagaagaaaa ggaagatggt     2100

ggagggtgct atgacatacc aaactggtca gcccttaaat atgcaggtct tcaaggttta     2160

atgtctgtat tggcagaaat aagaccaaag aatgacttgg ggcatccttt ttgtaataat     2220

ttgaggtctg gagattggat gattgactat gtcagtaacc ggcttatttc acgatcagga     2280

actattgctg aagttggtaa atggttgcag gctatgttct tctacctgaa gcagatccca     2340

cgttacctta tcccatgtta ctttgatgct atattaattg gtgcatatac cactcttctg     2400

gatacagcat ggaagcagat gtcaagcttt gttcagaatg gttcaacctt tgtgaaacac     2460

ctttcattgg gttcagttca actgtgtgga gtaggaaaat tcccttccct gccaattctt     2520

tcacctgccc taatggatgt accttatagg ttaaatgaga tcacaaaaga aaaggagcaa     2580

tgttgtgttt ctctagctgc aggcttacct catttttctt ctggtatttt ccgctgctgg     2640

ggaagggata cttttattgc acttagaggt atactgctga ttactggacg ctatgtagaa     2700

gccaggaata ttattttagc atttgcgggt accctgaggc atggtctcat tcctaatcta     2760

ctgggtgaag gaatttatgc cagatacaat tgtcgggatg ctgtgtggtg gtggctgcag     2820

tgtatccagg attactgtaa aatggttcca aatggactag acattctcaa gtgcccagtt     2880

tccagaatgt atcctacaga tgattctgct cctttgcctg ctggcacact ggatcagcca     2940

ttgtttgaag tcatacagga agcaatgcaa aaacacatgc agggcataca gttccgagaa     3000

aggaatgctg gtccccagat agatcgaaac atgaaggacg aaggttttaa tataactgca     3060

ggagttgatg aagaaacagg atttgtttat ggaggaaatc gtttcaattg tggcacatgg     3120

atggataaaa tgggagaaag tgacagagct agaaacagag gaatcccagc cacaccaaga     3180

gatgggtctg ctgtggaaat tgtgggcctg agtaaatctg ctgttcgctg gttgctggaa     3240

ttatccaaaa aaaatatttt cccttatcat gaagtcacag taaaaagaca tggaaaggct     3300

ataaaggtct catatgatga gtggaacaga aaaatacaag acaactttga aaagctattt     3360

catgtttccg aagacccttc agatttaaat gaaaagcatc caaatctggt tcacaaacgt     3420

ggcatataca aagatagtta tggagcttca agtccttggt gtgactatca gctcaggcct     3480

aattttacca tagcaatggt tgtggcccct gagctcttta ctacagaaaa agcatggaaa     3540

gctttggaga ttgcagaaaa aaaattgctt ggtccccttg gcatgaaaac tttagatcca     3600

gatgatatgg tttactgtgg aatttatgac aacgcattag acaatgacaa ctacaatctt     3660

gctaaaggtt tcaattatca ccaaggacct gagtggctgt ggcctattgg gtattttctt     3720

cgtgcaaaat tatatttttc cagattgatg ggcccggaga ctactgcaaa gactatagtt     3780

ttggttaaaa atgttctttc ccgacattat gttcatcttg agagatcccc ttggaaagga     3840

cttccagaac tgaccaatga gaatgcccag tactgtcctt tcagctgtga aacacaagcc     3900

tggtcaattg ctactattct tgagacactt tatgatttat ag                        3942


<210>  27
<211>  3759
<212>  DNA
<213>  artificial

<220>
<223>  Nucleic acid sequence encoding D6 hGDE

<400>  27
atgaactcca tccgaaaaat aatttgggag gatatttttc caaagcttaa actctgggaa       60

tttttccaag tagatgtcaa caaagcggtt gagcaattta gaagacttct tacacaagaa      120

aataggcgag taaccaagtc tgatccaaac caacacctta cgattattca agatcctgaa      180

tacagacggt ttggctgtac tgtagatatg aacattgcac taacgacttt cataccacat      240

gacaaggggc cagcagcaat tgaagaatgc tgtaattggt ttcataaaag aatggaggaa      300

ttaaattcag agaagcatcg actcattaac tatcatcagg aacaggcagt taattgcctt      360

ttgggaaatg tgttttatga acgactggct ggccatggtc caaaactagg acctgtcact      420

agaaagcatc ctttagttac caggtatttt actttcccat ttgaagagat agacttctcc      480

atggaagaat ctatgattca tctgccaaat aaagcttgtt ttctgatggc acacaatgga      540

tgggtaatgg gagatgatcc tcttcgaaac tttgctgaac cgggttcaga agtttaccta      600

aggagagaac ttatttgctg gggagacagt gttaaattac gctatgggaa taaaccagag      660

gactgtcctt atctctgggc acacatgaaa aaatacactg aaataactgc aacttatttc      720

cagggagtac gtcttgataa ctgccactca acacctcttc acgtagctga gtacatgttg      780

gatgctgcta ggaatttgca acccaattta tatgtagtag ctgaactgtt cacaggaagt      840

gaggacctag acaatgtctt tgttactaga ctgggcatta gttccttaat aagagaggca      900

atgagtgcat ataatagtca tgaagagggc agattagttt accgatatgg aggagaacct      960

gttggatcct ttgttcagcc ctgtttgagg cctttaatgc cagctattgc acatgccctg     1020

tttatggata ttacgcatga taatgagtgt cctattgtgc atagatcagc gtatgatgct     1080

cttccaagta ctacaattgt ttctatggca tgttgtgcta gtggaagtac aagaggctat     1140

gatgaattag tgcctcatca gatttcagtg gtttctgaag aacggtttta cactaagtgg     1200

aatcctgaag cattgccttc aaacacaggt gaagttaatt tccaaagcgg cattattgca     1260

gccaggtgtg ctatcagtaa acttcatcag gagcttggag ccaagggttt tattcaggtg     1320

tatgtggatc aagttgatga agacatagtg gcagtaacaa gacactcacc tagcatccat     1380

cagtctgttg tggctgtaac tagaactgct ttcaggaatc ccaagacttc attttacagc     1440

aaggaagtgc ctcaaatgtg catccctggc aaaattgaag aagtagttct tgaagctaga     1500

actattgaga gaaacacgaa accttatagg aaggatgaaa attcaatcaa tggaacacca     1560

gatatcacag tagaaattag agaacatatt cagcttaatg aaagtaaaat tgttaaacaa     1620

gctggagttg ccacaaaagg gcccaatgaa tatattcaag aaatagaatt tgaaaacttg     1680

tctccaggaa gtgttattat attcagagtt agtcttgatc cacatgcaca agtcgctgtt     1740

ggcattcttc gaaatcatct gacacaattc agtcctcact ttaaatctgg cagcctagct     1800

gttgacaatg cagatcctat attaaaaatt ccttttgctt ctcttgccta tagattaact     1860

ttggctgagc taaatcagat cctttaccga tgtgaatcag aagaaaagga agatggtgga     1920

gggtgctatg acataccaaa ctggtcagcc cttaaatatg caggtcttca aggtttaatg     1980

tctgtattgg cagaaataag accaaagaat gacttggggc atcctttttg taataatttg     2040

aggtctggag attggatgat tgactatgtc agtaaccggc ttatttcacg atcaggaact     2100

attgctgaag ttggtaaatg gttgcaggct atgttcttct acctgaagca gatcccacgt     2160

taccttatcc catgttactt tgatgctata ttaattggtg catataccac tcttctggat     2220

acagcatgga agcagatgtc aagctttgtt cagaatggtt caacctttgt gaaacacctt     2280

tcattgggtt cagttcaact gtgtggagta ggaaaattcc cttccctgcc aattctttca     2340

cctgccctaa tggatgtacc ttataggtta aatgagatca caaaagaaaa ggagcaatgt     2400

tgtgtttctc tagctgcagg cttacctcat ttttcttctg gtattttccg ctgctgggga     2460

agggatactt ttattgcact tagaggtata ctgctgatta ctggacgcta tgtagaagcc     2520

aggaatatta ttttagcatt tgcgggtacc ctgaggcatg gtctcattcc taatctactg     2580

ggtgaaggaa tttatgccag atacaattgt cgggatgctg tgtggtggtg gctgcagtgt     2640

atccaggatt actgtaaaat ggttccaaat ggactagaca ttctcaagtg cccagtttcc     2700

agaatgtatc ctacagatga ttctgctcct ttgcctgctg gcacactgga tcagccattg     2760

tttgaagtca tacaggaagc aatgcaaaaa cacatgcagg gcatacagtt ccgagaaagg     2820

aatgctggtc cccagataga tcgaaacatg aaggacgaag gttttaatat aactgcagga     2880

gttgatgaag aaacaggatt tgtttatgga ggaaatcgtt tcaattgtgg cacatggatg     2940

gataaaatgg gagaaagtga cagagctaga aacagaggaa tcccagccac accaagagat     3000

gggtctgctg tggaaattgt gggcctgagt aaatctgctg ttcgctggtt gctggaatta     3060

tccaaaaaaa atattttccc ttatcatgaa gtcacagtaa aaagacatgg aaaggctata     3120

aaggtctcat atgatgagtg gaacagaaaa atacaagaca actttgaaaa gctatttcat     3180

gtttccgaag acccttcaga tttaaatgaa aagcatccaa atctggttca caaacgtggc     3240

atatacaaag atagttatgg agcttcaagt ccttggtgtg actatcagct caggcctaat     3300

tttaccatag caatggttgt ggcccctgag ctctttacta cagaaaaagc atggaaagct     3360

ttggagattg cagaaaaaaa attgcttggt ccccttggca tgaaaacttt agatccagat     3420

gatatggttt actgtggaat ttatgacaac gcattagaca atgacaacta caatcttgct     3480

aaaggtttca attatcacca aggacctgag tggctgtggc ctattgggta ttttcttcgt     3540

gcaaaattat atttttccag attgatgggc ccggagacta ctgcaaagac tatagttttg     3600

gttaaaaatg ttctttcccg acattatgtt catcttgaga gatccccttg gaaaggactt     3660

ccagaactga ccaatgagaa tgcccagtac tgtcctttca gctgtgaaac acaagcctgg     3720

tcaattgcta ctattcttga gacactttat gatttatag                            3759


<210>  28
<211>  3327
<212>  DNA
<213>  artificial

<220>
<223>  Nucleic acid sequence encoding D7 hGDE

<400>  28
atggttacca ggtattttac tttcccattt gaagagatag acttctccat ggaagaatct       60

atgattcatc tgccaaataa agcttgtttt ctgatggcac acaatggatg ggtaatggga      120

gatgatcctc ttcgaaactt tgctgaaccg ggttcagaag tttacctaag gagagaactt      180

atttgctggg gagacagtgt taaattacgc tatgggaata aaccagagga ctgtccttat      240

ctctgggcac acatgaaaaa atacactgaa ataactgcaa cttatttcca gggagtacgt      300

cttgataact gccactcaac acctcttcac gtagctgagt acatgttgga tgctgctagg      360

aatttgcaac ccaatttata tgtagtagct gaactgttca caggaagtga ggacctagac      420

aatgtctttg ttactagact gggcattagt tccttaataa gagaggcaat gagtgcatat      480

aatagtcatg aagagggcag attagtttac cgatatggag gagaacctgt tggatccttt      540

gttcagccct gtttgaggcc tttaatgcca gctattgcac atgccctgtt tatggatatt      600

acgcatgata atgagtgtcc tattgtgcat agatcagcgt atgatgctct tccaagtact      660

acaattgttt ctatggcatg ttgtgctagt ggaagtacaa gaggctatga tgaattagtg      720

cctcatcaga tttcagtggt ttctgaagaa cggttttaca ctaagtggaa tcctgaagca      780

ttgccttcaa acacaggtga agttaatttc caaagcggca ttattgcagc caggtgtgct      840

atcagtaaac ttcatcagga gcttggagcc aagggtttta ttcaggtgta tgtggatcaa      900

gttgatgaag acatagtggc agtaacaaga cactcaccta gcatccatca gtctgttgtg      960

gctgtaacta gaactgcttt caggaatccc aagacttcat tttacagcaa ggaagtgcct     1020

caaatgtgca tccctggcaa aattgaagaa gtagttcttg aagctagaac tattgagaga     1080

aacacgaaac cttataggaa ggatgaaaat tcaatcaatg gaacaccaga tatcacagta     1140

gaaattagag aacatattca gcttaatgaa agtaaaattg ttaaacaagc tggagttgcc     1200

acaaaagggc ccaatgaata tattcaagaa atagaatttg aaaacttgtc tccaggaagt     1260

gttattatat tcagagttag tcttgatcca catgcacaag tcgctgttgg cattcttcga     1320

aatcatctga cacaattcag tcctcacttt aaatctggca gcctagctgt tgacaatgca     1380

gatcctatat taaaaattcc ttttgcttct cttgcctata gattaacttt ggctgagcta     1440

aatcagatcc tttaccgatg tgaatcagaa gaaaaggaag atggtggagg gtgctatgac     1500

ataccaaact ggtcagccct taaatatgca ggtcttcaag gtttaatgtc tgtattggca     1560

gaaataagac caaagaatga cttggggcat cctttttgta ataatttgag gtctggagat     1620

tggatgattg actatgtcag taaccggctt atttcacgat caggaactat tgctgaagtt     1680

ggtaaatggt tgcaggctat gttcttctac ctgaagcaga tcccacgtta ccttatccca     1740

tgttactttg atgctatatt aattggtgca tataccactc ttctggatac agcatggaag     1800

cagatgtcaa gctttgttca gaatggttca acctttgtga aacacctttc attgggttca     1860

gttcaactgt gtggagtagg aaaattccct tccctgccaa ttctttcacc tgccctaatg     1920

gatgtacctt ataggttaaa tgagatcaca aaagaaaagg agcaatgttg tgtttctcta     1980

gctgcaggct tacctcattt ttcttctggt attttccgct gctggggaag ggatactttt     2040

attgcactta gaggtatact gctgattact ggacgctatg tagaagccag gaatattatt     2100

ttagcatttg cgggtaccct gaggcatggt ctcattccta atctactggg tgaaggaatt     2160

tatgccagat acaattgtcg ggatgctgtg tggtggtggc tgcagtgtat ccaggattac     2220

tgtaaaatgg ttccaaatgg actagacatt ctcaagtgcc cagtttccag aatgtatcct     2280

acagatgatt ctgctccttt gcctgctggc acactggatc agccattgtt tgaagtcata     2340

caggaagcaa tgcaaaaaca catgcagggc atacagttcc gagaaaggaa tgctggtccc     2400

cagatagatc gaaacatgaa ggacgaaggt tttaatataa ctgcaggagt tgatgaagaa     2460

acaggatttg tttatggagg aaatcgtttc aattgtggca catggatgga taaaatggga     2520

gaaagtgaca gagctagaaa cagaggaatc ccagccacac caagagatgg gtctgctgtg     2580

gaaattgtgg gcctgagtaa atctgctgtt cgctggttgc tggaattatc caaaaaaaat     2640

attttccctt atcatgaagt cacagtaaaa agacatggaa aggctataaa ggtctcatat     2700

gatgagtgga acagaaaaat acaagacaac tttgaaaagc tatttcatgt ttccgaagac     2760

ccttcagatt taaatgaaaa gcatccaaat ctggttcaca aacgtggcat atacaaagat     2820

agttatggag cttcaagtcc ttggtgtgac tatcagctca ggcctaattt taccatagca     2880

atggttgtgg cccctgagct ctttactaca gaaaaagcat ggaaagcttt ggagattgca     2940

gaaaaaaaat tgcttggtcc ccttggcatg aaaactttag atccagatga tatggtttac     3000

tgtggaattt atgacaacgc attagacaat gacaactaca atcttgctaa aggtttcaat     3060

tatcaccaag gacctgagtg gctgtggcct attgggtatt ttcttcgtgc aaaattatat     3120

ttttccagat tgatgggccc ggagactact gcaaagacta tagttttggt taaaaatgtt     3180

ctttcccgac attatgttca tcttgagaga tccccttgga aaggacttcc agaactgacc     3240

aatgagaatg cccagtactg tcctttcagc tgtgaaacac aagcctggtc aattgctact     3300

attcttgaga cactttatga tttatag                                         3327


<210>  29
<211>  3912
<212>  DNA
<213>  artificial

<220>
<223>  Nucleic acid sequence encoding D8 hGDE

<400>  29
atgcatccag aatgtgccta taatcttgta aattctccac acttaaaacc tgcctgggtc       60

ttagacagag cactttggcg tttctcctgt gatgttgcag aagggaaata caaagaaaag      120

ggaatacctg ctttgattga aaatgatcac catatgaact ccatccgaaa aataatttgg      180

gaggatattt ttccaaagct taaactctgg gaatttttcc aagtagatgt caacaaagcg      240

gttgagcaat ttagaagact tcttacacaa gaaaataggc gagtaaccaa gtctgatcca      300

aaccaacacc ttacgattat tcaagatcct gaatacagac ggtttggctg tactgtagat      360

atgaacattg cactaacgac tttcatacca catgacaagg ggccagcagc aattgaagaa      420

tgctgtaatt ggtttcataa aagaatggag gaattaaatt cagagaagca tcgactcatt      480

aactatcatc aggaacaggc agttaattgc cttttgggaa atgtgtttta tgaacgactg      540

gctggccatg gtccaaaact aggacctgtc actagaaagc atcctttagt taccaggtat      600

tttactttcc catttgaaga gatagacttc tccatggaag aatctatgat tcatctgcca      660

aataaagctt gttttctgat ggcacacaat ggatgggtaa tgggagatga tcctcttcga      720

aactttgctg aaccgggttc agaagtttac ctaaggagag aacttatttg ctggggagac      780

agtgttaaat tacgctatgg gaataaacca gaggactgtc cttatctctg ggcacacatg      840

aaaaaataca ctgaaataac tgcaacttat ttccagggag tacgtcttga taactgccac      900

tcaacacctc ttcacgtagc tgagtacatg ttggatgctg ctaggaattt gcaacccaat      960

ttatatgtag tagctgaact gttcacagga agtgaggacc tagacaatgt ctttgttact     1020

agactgggca ttagttcctt aataagagag gcaatgagtg catataatag tcatgaagag     1080

ggcagattag tttaccgata tggaggagaa cctgttggat cctttgttca gccctgtttg     1140

aggcctttaa tgccagctat tgcacatgcc ctgtttatgg atattacgca tgataatgag     1200

tgtcctattg tgcatagatc agcgtatgat gctcttccaa gtactacaat tgtttctatg     1260

gcatgttgtg ctagtggaag tacaagaggc tatgatgaat tagtgcctca tcagatttca     1320

gtggtttctg aagaacggtt ttacactaag tggaatcctg aagcattgcc ttcaaacaca     1380

ggtgaagtta atttccaaag cggcattatt gcagccaggt gtgctatcag taaacttcat     1440

caggagcttg gagccaaggg ttttattcag gtgtatgtgg atcaagttga tgaagacata     1500

gtggcagtaa caagacactc acctagcatc catcagtctg ttgtggctgt aactagaact     1560

gctttcagga atcccaagac ttcattttac agcaaggaag tgcctcaaat gtgcatccct     1620

ggcaaaattg aagaagtagt tcttgaagct agaactattg agagaaacac gaaaccttat     1680

aggaaggatg aaaattcaat caatggaaca ccagatatca cagtagaaat tagagaacat     1740

attcagctta atgaaagtaa aattgttaaa caagctggag ttgccacaaa agggcccaat     1800

gaatatattc aagaaataga atttgaaaac ttgtctccag gaagtgttat tatattcaga     1860

gttagtcttg atccacatgc acaagtcgct gttggcattc ttcgaaatca tctgacacaa     1920

ttcagtcctc actttaaatc tggcagccta gctgttgaca atgcagatcc tatattaaaa     1980

attccttttg cttctcttgc ctatagatta actttggctg agctaaatca gatcctttac     2040

cgatgtgaat cagaagaaaa ggaagatggt ggagggtgct atgacatacc aaactggtca     2100

gcccttaaat atgcaggtct tcaaggttta atgtctgtat tggcagaaat aagaccaaag     2160

aatgacttgg ggcatccttt ttgtaataat ttgaggtctg gagattggat gattgactat     2220

gtcagtaacc ggcttatttc acgatcagga actattgctg aagttggtaa atggttgcag     2280

gctatgttct tctacctgaa gcagatccca cgttacctta tcccatgtta ctttgatgct     2340

atattaattg gtgcatatac cactcttctg gatacagcat ggaagcagat gtcaagcttt     2400

gttcagaatg gttcaacctt tgtgaaacac ctttcattgg gttcagttca actgtgtgga     2460

gtaggaaaat tcccttccct gccaattctt tcacctgccc taatggatgt accttatagg     2520

ttaaatgaga tcacaaaaga aaaggagcaa tgttgtgttt ctctagctgc aggcttacct     2580

catttttctt ctggtatttt ccgctgctgg ggaagggata cttttattgc acttagaggt     2640

atactgctga ttactggacg ctatgtagaa gccaggaata ttattttagc atttgcgggt     2700

accctgaggc atggtctcat tcctaatcta ctgggtgaag gaatttatgc cagatacaat     2760

tgtcgggatg ctgtgtggtg gtggctgcag tgtatccagg attactgtaa aatggttcca     2820

aatggactag acattctcaa gtgcccagtt tccagaatgt atcctacaga tgattctgct     2880

cctttgcctg ctggcacact ggatcagcca ttgtttgaag tcatacagga agcaatgcaa     2940

aaacacatgc agggcataca gttccgagaa aggaatgctg gtccccagat agatcgaaac     3000

atgaaggacg aaggttttaa tataactgca ggagttgatg aagaaacagg atttgtttat     3060

ggaggaaatc gtttcaattg tggcacatgg atggataaaa tgggagaaag tgacagagct     3120

agaaacagag gaatcccagc cacaccaaga gatgggtctg ctgtggaaat tgtgggcctg     3180

agtaaatctg ctgttcgctg gttgctggaa ttatccaaaa aaaatatttt cccttatcat     3240

gaagtcacag taaaaagaca tggaaaggct ataaaggtct catatgatga gtggaacaga     3300

aaaatacaag acaactttga aaagctattt catgtttccg aagacccttc agatttaaat     3360

gaaaagcatc caaatctggt tcacaaacgt ggcatataca aagatagtta tggagcttca     3420

agtccttggt gtgactatca gctcaggcct aattttacca tagcaatggt tgtggcccct     3480

gagctcttta ctacagaaaa agcatggaaa gctttggaga ttgcagaaaa aaaattgctt     3540

ggtccccttg gcatgaaaac tttagatcca gatgatatgg tttactgtgg aatttatgac     3600

aacgcattag acaatgacaa ctacaatctt gctaaaggtt tcaattatca ccaaggacct     3660

gagtggctgt ggcctattgg gtattttctt cgtgcaaaat tatatttttc cagattgatg     3720

ggcccggaga ctactgcaaa gactatagtt ttggttaaaa atgttctttc ccgacattat     3780

gttcatcttg agagatcccc ttggaaagga cttccagaac tgaccaatga gaatgcccag     3840

tactgtcctt tcagctgtga aacacaagcc tggtcaattg ctactattct tgagacactt     3900

tatgatttat ag                                                         3912


<210>  30
<211>  4134
<212>  DNA
<213>  Equus caballus

<400>  30
atgattcatt ttacaccatt gcagactctt ggactatcta ggtcatccta ctcccttgct       60

gaccagttag aattaaatcc tgacttttca agacctaata aaaagtatac ctggcatgat      120

gttggacagc tagtggaaaa attgaaaaag gaatgggata ttctttgtat tactgatgtt      180

gtctacaatc atactgctgc taatagtaaa tggatccatg aacatccaga aagtgcatat      240

aaccttgtga attctccaca cttaaaacct gcctgggtct tagacagagc actttggcat      300

ttatcctgtg atgtggcaga agggaaatac agagaaaaag gagtacctgc tctgattgaa      360

aatgatcatc aaatgaattg cattcgaaaa ataatttggg aggatattta tccaaagatt      420

cacctctggg aatttttcca agtagacgtt cacaaagcag ttgagcaatt tagaggactt      480

cttacacaag aaaataggaa aataatatct cagcctgatc caaagcaaca ccttaagatt      540

attcaggatc ctgaatacag acggcttggc tgtactgtag atatgaacat tgcactagca      600

actttcatac cacatgataa tgggccagct gcaattgatg aatgctgtaa ttggttccgt      660

aagagaattg aggaattaaa cgcagagaag catcaacttg tgaactatca tcaggagcag      720

gcagttaatt gccttttggg aaatgtattt tatgaacgac tggctggcca tggtcctaaa      780

ctaggacctg tcaccagaaa acatccttta gttaccagat attttacttt cccatttgaa      840

gaaatgaccc catccacaga agaatctatg attcatctcc caaataaagc ttgttttctg      900

atggcgcata atggatgggt aatgggagat gatccccttc ggaactttgc tgaaccaggt      960

tcagacgttt atctaaggag agaacttatc tgctggggag acagtgttaa attacgctat     1020

gggaataagc cagaggactg tccttacctc tgggcgcaca tgaaaaaata cactgaaata     1080

actgcaactc atttccaggg agtacgtctt gataactgcc actcaacacc aattcatgta     1140

gccgagtaca tgttggatgc cgctaggaaa ttgcaaccca atttatatgt agtagctgaa     1200

ctgttcacag gaagcgaaga cctggacaat atctttgtta ctagactggg cattagttcc     1260

ttaataagag aggcaatgag tgcagctgat agccatgagg agggcagatt agtttaccga     1320

tatggaggag agcctgttgg gtcctttgtt cagccctgtt tgaggccttt aatgccagct     1380

attgcacatg ccctgtttat ggatatcacc catgataatg agtgtcctat tgtgcatagg     1440

tcagcatatg atgctctccc gagttccacg attgtttcta tggcatcttg tgctagtgga     1500

agtactaaag gctatgatga attagtgcct catcagattt cagtggtttc tgaagaacga     1560

ttttatacta agtggaatcc tgaagcattg ccatcaaata caggtgaagt caatttccaa     1620

agcggaatta ttgcagccag gcgtgctatc aataaacttc atcaagagct tggggccaag     1680

ggtttcattc aggtgtatgt ggatcaggtt gatcaagata tagtggcggt aacaaggcac     1740

tcacctagca tccatcagtc tgttgtgtct gtgtcgagaa ctgctttcag gaatcccaag     1800

acgtcatttt acagcaagga agtgcctcat atgtacatcc ctggcaaaat tgaagaagta     1860

gttcttgaag ctagaactat tgagagacat acaatacctt ataagaagga tgaaaactca     1920

atcaatggaa tgccagatat cacagtagaa attagagaac atattcagct taatgaaagt     1980

aaaattgtta aacatgctgg aattgtcaca aaaggaccca atgaatttgt tcaagaaata     2040

gagtttgaaa acttgactcc aggaagtgtt attatattca gagttagtct tgatccacat     2100

gcacaagttg ctgttggaat tcttcgaaat catctgacac aattcagtcc tcactttaaa     2160

tctgggagcc ttgctgttga caacgcagat cctatattga aaattccttt tgcttctatt     2220

gcctctaaat taactttggc tgagctaaat caggtccttt atcgatgtga atcagaagaa     2280

caagaagatg gtggagggtg ttataacata ccaaactggt cgtctcttaa atatgcaggt     2340

cttcaaggat taatgtccat attggcagaa ataagaccaa ggaatgactt ggggcatccc     2400

ttttgtgaca atttgagatc tggagattgg atgattgact atgtcagtag ccggcttatt     2460

tcacgatcag gaactattgc tgaagttggt aaatggttgc aggctatgtt cctctacctg     2520

aagcagatcc cccgttatct tattccatgt tactttgatg ctatattaat tggtgcatac     2580

accactctcc tggatatagc atggaagcag atgtcaagct ttgttcagaa tggttctacc     2640

tttgtgaaac acctttctct gggttcagtc caaatgtgtg gagtaggaaa attcccttct     2700

ctgccacttc tttcaccttc ccttacggat ctaccatata gagtaaatga gatcacaaaa     2760

gaaaaggagc agtgttgtgg gtctctagct gcaggcttac ctcatttttc tgctggcatt     2820

ttccgctgct ggggaaggga taccttcatt gcgctcagag gtctgctgct ggttacggga     2880

cgctatttgg aggccaggaa tattatttta gcatttgctg gcaccctgag acacggtctc     2940

attcctaatc tcctgggtga aggaactcac gccagataca attgccggga tgctgtgtgg     3000

tggtggctac agtgtattca ggattactgt aaaattgttc caaatggcct ggacatcctc     3060

aggtgcccgg tttccagaat gtatcctaca gatgattctg ttcctttgtc tgctggcaca     3120

gtggatcaac cattgtttga agtaatacag gaagctatgc aaagacatgt gcagggcata     3180

cagttccgag aaaggaatgc tggtccacag atagatcgaa acatgaagga tgaaggtttt     3240

aatataactg caggagttga tgaagaaacg ggatttgttt atggaggaaa tcgcttcaat     3300

tgcggcacat ggatggataa aatgggagaa agtgacagag ctagaaacag aggaatcccg     3360

gccactccaa gagatgggtc tgctgtggaa attgtgggcc tgagtaaatc tgccgttcgt     3420

tggttgctgg aattatcccg aaaaaatatt ttcccttatc atgaagtccg agtaaaaaga     3480

catggaaagt ttgtgacagt ctcatatgat gagtggaaca gaaaaataca agacaacttt     3540

gaaaagctat ttcatgtgtc agaagaccct tcagatttta acgaaaagca tcctgagctg     3600

gttcacaaac gtggcatata caaagatagt tatggagcat caagcccttg gtgtgactac     3660

cagctcaggc ctaattttac catagcaatg gtcgtagccc ctgagctgtt taccccagaa     3720

aaagcatgga aagctttgga gattgcagaa aaaaaattgc ttggtcccct tggcatgaaa     3780

actttggatc cagatgatat ggtttactgt ggaatttatg acaatgcctt agacaatgac     3840

aactacaatc ttgctaaagg tttcaattat caccaaggac ctgagtggct gtggcccact     3900

ggatattttc ttcgtgcaaa attgtatttt tccaaattaa tgggtccaga gactaatgca     3960

aagactatgt ttttggttaa aaacgtcctt tccagacatt atgttcatct tgagagatcc     4020

ccttggaaag gacttccaga actgactaat gagaatggcc aatactgtcc tttcagctgt     4080

gaaacacaag cctggtcaat tgctactgtt cttgaaacac tctatgactt atag           4134


<210>  31
<211>  4098
<212>  DNA
<213>  Gorilla gorilla

<400>  31
atgggacaca gtaaacagat tcgaatttta cttctgaacg aaatggagaa actggaaaag       60

accctcttca gacttgaaca agggtatgaa ctacagttcc gattaggccc aactttacag      120

ggaaaagcag ttaccgtgta tacaaattac ccatttcctg gagaaacatt taatagagaa      180

aaattccgtt ctctggattg ggaaaatcca acagaaagag aagatgattc tgataaatac      240

tgtaaactta atctgcaaca atctggttca tttcagtatt atttccttca aggaaatgag      300

aaaagtggtg gaggttacat agttgtggac cccattttac gtgttggtgc tgataatcat      360

gtgctaccct tggactgtgt tactcttcag acatttttag ctaagtgttt gggacctttt      420

gatgaatggg aaagcagact tagggttgca aaagaatcag gctacaacat gattcatttt      480

accccattgc agactcttgg actatctagg tcatgctact cccttgccaa tcagttagaa      540

ttaaatcctg acttttcaag acctaataga aagtatacct ggaatgatgt tggacagcta      600

gtggaaaaat taaaaaagga atggaatgtt atttgtatta ctgatgttgt ctacaatcat      660

actgctgcta atagtaaatg gatccaggaa catccagaat gtgcctataa tcttgtgaat      720

tctccacact taaaacctgc ctgggtctta gacagagcac tttggcgttt ctcctgtgat      780

gttgcagaag ggaaatacaa agaaaaggga atacctgctt tgattgaaaa tgatcaccat      840

atgaattcca tccgaaaaat aatttgggag gatatttttc caaagcttaa actctgggaa      900

tttttccaag tagatgtcaa caaagcggtt gagcaattta gaagacttct tacacaagaa      960

aataggcgag taaccaagtc tgatccaaac caacatctta cgattattca agatcctgaa     1020

tacagacggt ttggctgtac tgtagatatg aacattgcac taacgacttt cataccacat     1080

gagtatttta ctttcccatt tgaagagata gacttctcca tggaagaatc tatgattcat     1140

ctcccaaata aagcttgttt tctgatggca cacaatggat gggtaatggg agatgatcct     1200

cttcgaaact ttgctgaacc gggttcagaa gtttacctaa ggagagaact tatttgctgg     1260

ggagacagtg ttaaattacg ctatgggaat aaaccagagg actgtcctta tctctgggca     1320

cacatgaaaa aatacactga aataactgca acttatttcc agggagtacg tcttgataac     1380

tgccactcaa cacctcttca cgtagctgag tacatgttgg atgctgctag gaatttgcaa     1440

cccaatttat atgtagtagc tgaactgttc acaggaagtg aagatctgga caatgtcttt     1500

gttactagac tgggcattag ttccttaata agagaggcaa tgagtgcata taatagtcat     1560

gaagagggca gattagttta ccgatatgga ggagaacctg ttggatcctt tgttcagccc     1620

tgtttgaggc ctttaatgcc agctattgca catgccctgt ttatggatat tacgcatgat     1680

aatgagtgtc ctattgtgca tagatcagcg tatgatgctc ttccaagtac tacaattgtc     1740

tctatggcgt gttgtgctag tggaagtaca agaggctatg atgaattagt gcctcatcag     1800

ttcctaggca aaattgaaga agtagttctt gaagctagaa ctattgagag aaacatgaaa     1860

ccttatagga aggatgagaa ttcaatcaat ggaacgccag atatcacagt agaaattaga     1920

gaacatattc agcttaatga aagtaaaatt gttaaacaag ctggagttgc cacaaaaggg     1980

cccaatgaat atattcaaga aatagaattt gaaaacttgt ctccaggaag tgttattata     2040

ttcagagtta gtcttgatcc acatgcacaa gtcgctgttg gaattcttcg aaatcatctg     2100

acacaattca gtcctcactt taaatctggc agcctagctg ttgacaatgc agatcctata     2160

ttaaaaattc cttttgcttc tattgcctcc agattaactt tggctgagct aaatcagatc     2220

ctttaccgat gtgaatcaga agaaaaggaa gatggtggag ggtgctatga cataccaaac     2280

tggtcagccc ttaaatatgc aggtcttcaa ggtttaatgt ctgtattggc agaaataaga     2340

ccaaagaatg acttggggca tcctttttgt aataatttga gatctggaga ttggatgatt     2400

gactatgtca gtaaccggct tatttcacga tcaggaacta ttgctgaagt tggtaaatgg     2460

ttgcaggcta tgttcttcta cctgaagcag atcccacgtt accttatccc atgttacttt     2520

gatgctatat taattggtgc atataccact cttctggata cagcatggaa gcagatgtca     2580

agctttgttc agaatggttc aacctttgtg aaacaccttt cattgggttc agttcaactg     2640

tgtggagtag gaaaattccc ttccctgcca attctttcac ctgccctaat ggatgtacct     2700

tataggttaa atgagatcac aaaagaaaag gagcaatgtt gtgtttctct agctgcaggc     2760

ttacctcatt tttcttctgg tattttccgc tgctggggaa gggatacttt tattgcactt     2820

agaggtatac tgctgattac tggacgctat gtagaagcca ggaatattat tttagcattt     2880

gcgggtaccc tgaggcatgg tctcattcct aatctactgg gtgaaggaat ttatgccaga     2940

tacaattgtc gggatgctgt gtggtggtgg ctgcagtgta tccaggatta ctgtaaaatg     3000

gttccaaatg gtgtagacat tctcaagtgc ccagtttcca gaatgtatcc tacagatgat     3060

tctgctcctt tgcctgctgg cacactggat cagccattgt ttgaagtcat acaggaagca     3120

atgcaaaaac acatgcaggg catacagttc cgagaaagga atgctggtcc ccagatagat     3180

cgaaacatga aggacgaagg ttttaatata actgcaggag ttgatgaaga aacaggattt     3240

gtttatggag gaaatcgttt caattgtggc acatggatgg ataaaatggg agaaagtgac     3300

agagctagaa acagaggaat cccagccaca ccaagagatg ggtctgctgt ggaaattgtg     3360

ggcctgagta aatctgctgt tcgctggttg ctggaattat ccaaaaaaaa tattttccct     3420

tatcatgaag tcacagtaaa aagacatgga aaggctataa aggtctcata tgatgagtgg     3480

aacagaaaaa tacaagacaa ctttgaaaag ctatttcatg tttcagaaga cccttcagat     3540

ttaaatgaaa agcatccaaa tctggttcac aaacgtggca tatacaaaga tagttatgga     3600

gcgtcaagtc cttggtgtga ctatcagctc aggcctaatt ttaccatagc aatggttgtg     3660

gcccctgagc tctttactac agaaaaagca tggaaagctt tggagattgc agaaaaaaaa     3720

ttgcttggtc cccttggcat gaaaacttta gatccagatg atatggttta ctgtggaatt     3780

tatgacaatg cattagacaa tgacaactac aatcttgcta aaggtttcaa ttatcaccaa     3840

ggacctgagt ggctgtggcc tattgggtat tttcttcgtg caaaattata tttttccaga     3900

ttgatgggcc cggagactac tgcaaagact atagttttgg ttaaaaatgt tctttcccga     3960

cattatgttc atcttgagag atccccttgg aaaggacttc cagaactgac caatgagaat     4020

gcccagtact gtcctttcag ctgtgaaaca caagcctggt caattgctac tattcttgag     4080

acactttatg atttgtag                                                   4098


<210>  32
<211>  3900
<212>  DNA
<213>  Pongo abelii

<400>  32
atggggcaca gtaaacagat tcgaatttta cttctgaacg aaatggagaa gctggaaaag       60

accctcttca gacttgaaca agggtatgaa ctacagttcc gattaggccc aactttacag      120

ggaaaagcag ttaccgtgta tacaaattac ccatttcctg gagaaacatt taatagagaa      180

aaattccgtt ctctggattg ggaaaatcca acagaaagag aagatgattc tgataaatac      240

tgcaaactta atctgcaaca atctggttca tttcagtatt atttccttca aggaaatgag      300

aaaagtggtg gaggttacat agttgtggac cccattttac gtgttggtgc cgataatcat      360

gtgctaccct tggactgtgt tactcttcag acatttttag ctaagtgttt gggacctttt      420

gatgaatggg aaagcagact tagggttgca aaagaatcag gctacaacat gattcatttt      480

accccactgc agactcttgg actatctagg tcatgctact cccttgccaa tcagttagaa      540

ttaaatcctg acttttcaag acctaataga aagtatacct ggaatgatgt tggacagcta      600

gtggaaaaat taaaaaagga atggaatgtt atttgtatta ccgatgttgt ctacaatcat      660

actgctgcta atagtaaatg gatccaggaa catccagaat gtgcctataa tcttgtgaat      720

tctccacact taaaacctgc ctgggtctta gacagagcac tttggcgttt ctcctgtgat      780

gttgcagaag ggaaatacaa agaaaaggga atacctgctt tgattgaaaa tgatcaccat      840

atgaattcca tccgaaaaat aatttgggag gatatttttc caaagcttaa actctgggaa      900

tttttcgaag tagatgtcaa caaagcggtt gagcaattta gaagacttct tacacaagaa      960

aataggcgag taaccaagtc tgatccaaac caacatctta cgattattca ggatcctgaa     1020

tacagacggt ttggctgtac tgtagatatg aacattgcac taacgacttt cataccacat     1080

gacaatgggc cagcagcaat tgaagagtgc tgtaactggt ttcgtaagag aattgaggaa     1140

ttaaattcag agaagcatca actcattaac tatcatcagg aacaggcagt gaattgcctt     1200

ttgggaaatg tgttttatga acgactggct ggccatggtc caaaactagg acctgtcact     1260

agaaagcatc ctttagttac caggtatttt actttcccat ttgaagagat ggacttctcc     1320

atggaagaat ctatgattca tctcccaaat aaagcttgtt tactgatggc acacaatgga     1380

tgggtaatgg gagatgatcc tcttcgaaac tttgctgaac cgggttcaga agtttaccta     1440

aggagagaac ttatttgctg gggagacagt gttaaattac gctatgggaa taaaccagag     1500

gactgtcctt atctctgggc acacatgaaa aaatacactg aaataactgc aacttatttc     1560

cagggagtac gtcttgataa ctgccactca acacctcttc acgtagctga gtacatgttg     1620

gatgctgcta ggaatttgca acccaattta tatgtagtag ctgaactgtt cacaggaagt     1680

gaagatctgg acaatgtctt tgttactaga ctgggcatta gttccttaat aagagaggca     1740

atgagtgcat atgatagtca tgaagagggc agattagttt accgatatgg aggagaacct     1800

gttggatcct ttgttcagcc ctgtttgagg cctttaatgc cggctattgc acatgccctg     1860

tttatggata ttacacatga taatgagtgt cctattgtgc atagatcagc gtatgatgct     1920

cttccaagta ctacaattgt ttctatggcg tgttgtgcta gtggaagtac aagaggctat     1980

gatgaattag tgcctcatca gatttcggtg gtttctgaag aacggtttta cactaagtgg     2040

aatcctgaag cattgccttc aaatacaggt gaagttaatt tccaaagcgg cattattgca     2100

gccaggtgtg ctatcaataa acttcatcag gagcttggag ccaagggttt tattcaggtg     2160

tatgttgatc aagttgatga agacatagtg gcagtaacaa gacactcacc tagcatccat     2220

cagtctgttg tggctgtatc tagaactgct ttcaggaatc ccaagacttc attttacagc     2280

aaggaagtgc ctcaaatgtg catccctggc aaaattgaag aagtagttct tgaagctaga     2340

actattgaga gaaacacgaa accttatagg aaggatgaga attcaatcaa tggaacgcca     2400

gatatcacag tagaaattag agaacatatt cagcttaatg aaagtaaaat tgttaaacaa     2460

gctggagttg ccacaaaagg gcccaatgaa tttattcaag aaatagaatt tgaaaacttg     2520

tctccaggaa gtgttattat attcagagtt agtcttgatc cacatgcaca agtcgctgtt     2580

ggaattcttc gaaatcatct gacacaattc agtcctcact ttaaatctgg cagcctagct     2640

gttgacaatg cagatcctat attaaaaatt ccttttgctt tacctcattt ttcttctggt     2700

attttccgct gctggggaag ggatactttt attgcactta gaggtatgct gctgattact     2760

ggacgctatg tagaagccag gaatattatt ttagcatttg ctggtaccct gaggcatggt     2820

ctcattccta atctactggg tgaaggaact tatgccagat acaattgtcg ggacgctgtg     2880

tggtggtggc tgcagtgtat ccaggattac tgtaaagtgg ttccaaatgg tctagacatt     2940

ctcaagtgcc cagtttccag aatgtatcct acagatgatt ctgctccttt gcctgctggc     3000

gcactgttta atataactgc aggagttgat gaagaaacag gatttgttta tggaggaaat     3060

cgtttcaatt gtggcacatg gatggataaa atgggagaaa gtgacagagc tagaaacaga     3120

ggaatcccag ccacaccaag agatgggtct gctgtggaaa ttgtgggcct gagtaaatct     3180

gctgttcgct ggttgctgga attatccaaa aaaaatattt tcccttatca tgaagtcaca     3240

gtaaaacatg gaaaggctat aaaggtctca tatgatgagt ggaacagaaa aatacaggat     3300

aactttgaaa agctgtttca tgtttcagaa gacccttcag atttaaatga aaagcatcca     3360

aatttggttc acaaacgtgg catatacaaa gatagttatg gagcttcaag tccttggtgt     3420

gactatcagc tcaggcctaa ttttaccata gcaatggttg tggcccctga gctctttact     3480

acagaaaaag catggaaagc tttggagatt gcagaaaaaa aattgcttgg tccccttggc     3540

atgaaaactt tagatccaga tgatatggtt tactgtggaa tttatgacaa tgcattagac     3600

aatgacaact acaatcttgc taaaggtttc aattatcacc aaggacctga gtggctgtgg     3660

cctattgggt attttcttcg tgcaaaatta tatttttcca gattgatggg cccggagact     3720

actgcaaaga ctatagtttt ggttaaaaat gttctttccc gacattatgt tcatcttgag     3780

agatcccctt ggaaaggact tccagaactg accaatgaga atgcccagta ctgtcctttc     3840

agctgtgaaa cacaagcctg gtcagttgct actattcttg agacacttta tgatttatag     3900


<210>  33
<211>  4173
<212>  DNA
<213>  Pteropus alecto

<400>  33
atgggtcacg gtaaacagat tagaatttta cttctgaacg aaatggaaaa gcttgaaaag       60

accctcttta gacttgaaca agggtttgaa ctacagttcc gattaggccc aactttacaa      120

ggaaaaacag ttactgtgca tacaaattac ccatatcctg gagaaacatt taatcgagaa      180

aaattccgtt ccctggaatg ggaaaatcca tcagaaagag aagatgattc tgataaatac      240

tgtaaactta atctccaaca agcgggatca tttcagtatt acttccttcg aggaaatgag      300

aagagtggtg ggggttacat agttgtggat cctgtattac gtgttggtac tgataatcat      360

gtgttaccct tagactgtgt tactctccag acatttttag ctaagtgttt gggacccttg      420

gatgaatggg aaagcagact tagggttgca aaagaatcag gttacaacat gattcacttt      480

accccattgc agactcttgg ccagtctagg tcatgctact ctcttgctga tcagttagaa      540

ttaaatcctg acttttccag acctaataaa aagtgtacct gggatgatgt tggacagcta      600

gtggaaaaat tgaaaaagga atggaatatt ctttgtatca ccgatgttgt ctacaatcat      660

accggaaata ggaaaataac caagcctgat ccaaaagaac accttaagat aattcaggat      720

cctgaataca ggaggcttgg ctgtactgta gatatgaaca ttgcactagc gactttcata      780

ccaaatgagt attttacttt cccatttgag gaaatgaccc tctccacaga agaatctatg      840

attcatctcc caaataaagc ttgttttctg atggcacata atggatgggt aatgggagat      900

gatccccttc gaaactttgc tgaaccaggt tcagatgttt atctgaggag agaacttatt      960

tgctggggag acagtgttaa attacgctat gggaataaac cagaggactg tccttatctc     1020

tgggcacaca tgaaaaaata cactgaaata actgcaactt atttccaggg agtacgtctt     1080

gataactgcc actccacacc tcttcatgta gctgagtaca tgttggatgc tgctaggaaa     1140

ttgcaaccca atttatatat agtggcagaa ctgttcacag gaagtgaaga cttggacaat     1200

gtctttgtta ctagactggg aattagttcc ttaataagag aggcaatgag tgcacatgat     1260

agtcatgaag agggcagatt agtttaccga tatggaggag aacccgttgg gtcatttgtt     1320

cagccctgtt tgaggccttt gatgccagct attgcacatg ccctgtttat ggatattacc     1380

catgataatg agtgtcctat tgtgcataga tcagcatatg atgctctccc aagttccatg     1440

attgtttcta tggcgtgttg tgctagtggt agtactaaag gctatgatga attagtgcct     1500

catcaggtgt atgtggatca ggttgatgaa gacatagtgg cagtaacaag acactcacct     1560

agtatccatc agtctgttgt ggctgtgtct agaactgctt tcaagaatcc caagacttca     1620

ttttacagca aggaagtccc tcaaatgtgc atccctggca aaattgaaga agtagttctt     1680

gaagctagaa ctattgaaag aaatacaaaa ccttataaga gggatgaaaa ttcaatcaat     1740

ggaatgccag atatcacagc agaaattaga gaacatattc agcttaatga aagtaaaatt     1800

gttaaacaag ctggaattgc cacaaaagga cccaatgaat acattcaaga aatagaattt     1860

gaaaacttgt ctccaggaag tgttattgta ttcagagtta gtctcgatcc acatgcacaa     1920

gtcgctgttg gaattcttcg aaatcattta actcagttca gtcctcactt taaatctggg     1980

agcctttctg ccgacagctc agatcctata ttaaaaattc ctttcgctta tattgcctct     2040

aaattaactt tggctgagct aaatcaaata ctttaccggt gtgaatcaga agaacaagaa     2100

gatggtgggg gatgttataa tataccaaac tggtcatctc ttaaatatgc aggtcttcaa     2160

gagaatagtt ctttggagtt agctccttat gtgggctttg gtggaggttg tggggcagca     2220

cctgcaggtc taaatcgggg tgggggtgtt cggtccgacc aggcctcact agagcgattc     2280

ctgactacct tgcttgccac tgtggactat acagcccttg tgtccacttc tgtatgttca     2340

ccccacatca ctggacacga gcagcagccc aggctatggg aacgaattgc ctctgccaat     2400

aatatagcat gctatttcta tgacttttca ggattaatgt ctgtattagc agaaatgaga     2460

ccaaagaatg acttggggca tcctttttgt gataatttga gatctggaga ttggatgatt     2520

gactatgtca gtaatcggct tatttcacga tcgggaacta ttgctgaagt tggcagatgg     2580

ttgcaggcta tgttcttcta cctgaagcag atcccacgct atcttatccc atgttatttc     2640

gatgctgtat taatcggtgc atacaccact cttctggata cggcatggaa acaaatgtca     2700

agctttgttc agaatggttc tacctttgtg aaacaccttt cattgggttc tgtccagctg     2760

tgtggagtag gaaaatacgc ttctcttcca cttctttcac cttcgcttat ggatgtacca     2820

tacaggctaa atgagatcac aaaagaaaag gagcaatgtt gtgtgactct agctgcaggc     2880

ttgcctcatt tttcttctgg tattttccgc tgctggggaa gggatacttt tattgcactt     2940

agaggtatac tgctgattac cgggcgctat ttagaagcca ggaatattat tttagcgttt     3000

gctggtacct tgagacacgg tctcattcct aatctcctgg gtgaaggaac ttatgccaga     3060

tacaactgcc gggatgccgt gtggtggtgg ctgcagtgta ttcaagacta ctgtaaagtg     3120

gttccaaatg gcctagacat tctcaagtgc cctgtctcca gaatgtatcc tacagatgat     3180

tctgttcctt tgtcggccgg cacagtggat cagccattgt ttgaagtaat acaagaagct     3240

atgcagaggc acatgcaggg catacagttc cgagaaagga atgctggtcc acagatagat     3300

cgaaacatga aggatgaagg ttttaatata actgtagggg ttgatgaaga aacaggattt     3360

gtttatggag gaaatcgctt caattgcggc acatggatgg ataaaatggg agaaagtgac     3420

agagctagaa acagaggaat cccagccact ccaagagatg gatctgctgt ggaaattgtg     3480

ggcctaagta aatctgccat tcgctggttg ctggaattat ctaaaaaaaa tatttttcct     3540

tatcatgaag tcacagtaaa aagagatgga aaggttgtga cagtctcata tgatgagtgg     3600

aacagaaaaa tacaagacaa ctttgaaaag ctattttatg tgtccgaaga cccttcagac     3660

tttaatgaaa agaatccaaa tctggttcac aaacgtggta tatacaaaga cagttatgga     3720

gcttcaagcc cttggtgtga ctatcagctc aggcctaatt ttaccatagc aatggttgta     3780

gcccctgagc tctttactac agaaaaagca tggaaagctt tacaggtggc agaaaaaaaa     3840

ttgcttggtc cccttggcat gaaaactttg gatccagatg atatggttta ctgtggagtt     3900

tatgacaatg ccttagacaa tgacaactac aatcttgcga aaggtttcaa ttatcatcaa     3960

ggacctgagt ggctttggct cattgggtat tttcttcgtg caaaattata tttttccaaa     4020

ttaatgggtc cagagacgaa tgcaaagact atttttttgg ttaaaaatgt tctttcccgg     4080

cactatgttc atcttgagag tctggcttgt tttgccctca ccactctgct gcagctgctc     4140

aacaagatcc tttctgcttc ccagatccca tga                                  4173


<210>  34
<211>  3759
<212>  DNA
<213>  Cercocebus atys

<400>  34
atgaattcca tccgaaaaat gatttgggag gatatttttc caaagcttaa actctgggaa       60

tttttccaag tagacgtcaa caaaaaaaaa aaaaaaaaaa aaagacttct tacacaagaa      120

aataggagag taaccaagtc tgatccacac caacatctta agattattca agatcctgaa      180

tacagacgat ttggctgtac tgtagatatg aacattgcac taacgacttt cataccacat      240

gacaatgggc cagcagcaat tgaagaatgc tgtaattggt ttcgtaagag aattgaggaa      300

ttaaattcag agaagcatcg actcattaac tatcatcagg aacaggcagt taattgcctt      360

ttgggaaatg tgttttatga acgactggct ggccatggtc caaaactagg acctgtcact      420

agaaagcatc ctttagttac caggtatttt actttcccat ttgaagaaat ggacttctcc      480

gtggaagaat ctatgattca tctcccaaat aaagcttgtt ttctgatggc acacaatgga      540

tgggtaatgg gagatgatcc tcttcgaaac tttgctgaac caggctcaga agtttaccta      600

aggagagaac ttatttgctg gggagacagt gttaaattgc gctatgggaa taaaccagag      660

gactgtcctt ttctctgggc acacatgaaa aaatacactg aaataactgc aacttatttc      720

cagggagtac gtcttgataa ctgccactca acacctcttc atgtagctga gtacatgttg      780

gatgctgcta ggaatttgca acccaattta tatgtagtag ctgaactgtt cacaggaagt      840

gaagatctgg acaatatctt tgttactaga ctgggcatta gttccttaat aagagaggca      900

atgagtgcat ataatagtca tgaagagggc agattagttt accgatatgg aggagaacct      960

gttggatcct ttgttcagcc ctgtttgagg cctttaatgc cagctattgc acatgccttg     1020

tttatggata ttacccatga taatgagtgt cctattgtgc atagatcagc atatgatgct     1080

cttccaagta ctacaattgt ttctatggcg tgttgtgcta gtggaagtac aagaggctat     1140

gatgaattag tgcctcatca gatttcagtg gtttctgagg aacggtttta cactaagtgg     1200

aatcctggag cattgccttc aaatacaggt gaagttaatt tccaaagcgg cattattgca     1260

gccaggtgtg ctatcaataa gcttcatcag gagcttggag ccaagggttt tattcaggtg     1320

tatgtggatc aagttgatga agacatagtg gcagtaacaa gacactcacc tagcatccat     1380

cagtctgttg tggctgtatc tagaactgct ttcaggaatc ccaagacttc attttacagc     1440

aaggaagtgc ctcaaatgtg catccctggc aaaattgaag aagtagttct tgaagctaga     1500

actattgaga gaaatacgaa accttacagg aaggatgaga attcaatcaa tggaatgcca     1560

gatatcacag tagaaattag agaacatatt cagcttaatg aaagtaaaat tgttaaacaa     1620

gctggagttg ccacaaaagg gcccaatgaa tatattcaag aaatagaatt tgaaaacttg     1680

tctccaggaa gcgttattat attcagagtt agtcttgatc cacacgcaca agtcgctgtt     1740

ggaattcttc gaaatcatct gacccaattc agtcctcact ttaaatctgg gagcctagct     1800

gttgacaatt cagatcctat attaaaaatt ccctttgctt ctattgcctc caaattaact     1860

ttggctgagc taaatcagat cctttaccga tgtgaatcag aagaaaagga agatggtgga     1920

gggtgctatg acataccaaa ctggtcagcc cttaaatatg caggtcttca aggtttaatg     1980

tctgtattgg cagaaataag accaaagaat gacttgggcc atcctttttg taataatttg     2040

agatctggag attggatgat tgactatgtc agtaaccggc ttatttcacg atcaggaact     2100

attgctgaag ttggtaaatg gttgcaggct atgttcttct acctgaagca gatcccacgt     2160

taccttatcc catgttactt tgatgctata ttaattggtg catataccac tcttctggat     2220

atagcatgga agcagatgtc aagctttgtt cagaatggtt caacctttgt gaaacacctt     2280

tcattgggtt cagttcaact gtgtggagta ggaaaattcc cttccctgcc aattctttca     2340

cctgcactaa cgggtgtacc ttatagatta aatgagatca caaaagaaaa ggagcaatgt     2400

tgtgtttctc tagctgcagg cttacctcat ttttcttctg gtattttccg ctgctgggga     2460

agggatactt ttattgcact tagaggcata ctgctgatta ctggacgcta tgtagaagcc     2520

aggaatatta ttttagcatt tgctggtacc ctgaggcatg gtctcattcc taatctactg     2580

ggtgaaggaa cttatgccag atacaattgt cgggatgctg tgtggtggtg gctgcagtgt     2640

atccaggatt actgtaaaat ggttccaaat ggtctagaca ttctcaagtg tccagtttcc     2700

agaatgtatc ctacagatga ttctgctcct ttgcctgctg gcacactgga tcagccattg     2760

tttgaagtca tacaggaagc aatgcaaaga cacatgcagg gcatacagtt ccgagaaagg     2820

aatgctggtc ccaagataga tcgaaacatg aaggatgaag gttttaatgt aactgcagga     2880

gttgatgaag aaacaggatt tgtttatgga ggaaatcgtt tcaattgtgg cacatggatg     2940

gataaaatgg gagaaagtga cagagctaga aacacaggaa tcccagccac accaagagat     3000

gggtctgctg tggaaattgt gggactgagt aaatctgctg ttcgctggtt gctggaatta     3060

tccaaaaaaa atattttccc ttatcatgaa gtcacagtaa aaagacatgg aaaggttgta     3120

aaggtctcat atgatgagtg gaacagaaaa atacaagaca actttgaaaa gctatttcat     3180

gtttcagaag acccttcaga tttaaatgaa aagcatccaa atctggttca caaacgtggc     3240

atatacaaag atagttatgg agcttcaagt ccctggtgtg actatcagct caggcctaat     3300

tttactatag caatggttgt ggcccctgag ctctttacta cagcaaaagc atggaaagct     3360

ttggagattg cagaaaaaaa attgcttggt ccccttggca tgaaaacttt agatccagat     3420

gatatggttt actgtggaat ttatgacaat gcattagaca atgacaacta caatcttgca     3480

aaaggtttca attatcacca aggacctgag tggctgtggc ctattggata ttttcttcgt     3540

gcaaaattat atttttccag attgatgggc ccggagacta ctgcaaagac tatagttttg     3600

gttaaaaatg ttctttcccg acactatgtt catcttgaga gatccccttg gaaaggactt     3660

ccagaactga ccaatgagaa tgcccaatac tgtcctttca gctgtgaaac acaagcctgg     3720

tcaatttcta ctattcttga gacactttat gatttatag                            3759


<210>  35
<211>  3351
<212>  DNA
<213>  Ornithorhynchus anatinus

<400>  35
atgtttgaag gcagagcgga aggagtcgtt ggagagtact ttacttttcc gtatggagaa       60

atgacttctg tagaagaaga atctttgatg catcaacctg aaaaagcttg ttttttcatg      120

gcccataatg gttgggtcat gggagatgat ccattgagaa attttgctga gccagggtca      180

gatgtttacc tcaggagaga gcttgtttgc tggggagaca gtgttaaatt acgttatgga      240

aataaaccag aagactgccc ttacctctgg gcccacatga aaaaatatac tgaaataact      300

gccaagtatt ttcaaggagt gcgtcttgac aactgccact cgacacctct tcacgtagct      360

gagtatatgc tggatgctgc taggaaattg cagcccaatt tgtatgtagt ggctgagctg      420

ttcacaggaa gtgaggagct ggacaatatc tttgtgacta gactgggcat tagctcctta      480

ataagagaag ctatgagtgc atataatagc catgaagaag gcagattagt gtaccgcttt      540

ggaggagagc cagtgggatc tttcgttcag ccgtgtttga gacctttgat gccagctatt      600

gcacatgctc tgtttatgga tatcactcat gataacgaat gtcctattgt gcatcgatca      660

gcatatgatg ctcttccgag ctccaccata gtttccatgg cttgctgtgc tagtggaagt      720

actaggggct atgatgaatt agtacctcat cagatttctg tagtttctga agaacggttt      780

tataccaagt ggaacccagc agctactcta tcaaacccat ctgaagttaa tctccagact      840

ggaattatag caggaagacg tgccataaat aagctgcacc aagaacttgg agctaaaggt      900

tttattcagg tttatgtgga tcaggttgat gaagacatag tagcagtgac gagacactgt      960

cctagctctc accagtccgt agtggccgtg tctcgcactg cttttagaaa ccccaagact     1020

tctgcttaca gcaaagaagt gccgcagatg tgcatcccag gtaaaattga agaagtagtt     1080

cttgaggcca gaactgttga aagaaatgtt ggttcctacg taaaggatgc aaaatccatc     1140

aatggaatgc ccgacatcac agtagaaatt agagaacaca tccagcttaa tgaaagtaaa     1200

attgtaaaac aagctggagt tgccacaaaa ggtcttcatg aatatgtcca agaaatagaa     1260

tttgaaaatt tgaccccagg aagtgttatt atatttcgag taagccttga tccacacgca     1320

caagtggctg ttggaatact tcggaatcac ctgacacaat tcagtcctaa ttttaaaatt     1380

ggaagccttc ctgttgacaa ttcagatcct atattaaaaa ttccttttgc ttctatttca     1440

tctaaattaa ctttagctga cctaaatcaa ttactctacc gatgtgagtc agaagaacaa     1500

gaagatggtg gaggatgtta tgatgtacca aactggtcac ccctcaaata tgggggcctt     1560

caaggattaa tgtcagtaat ggctgaaatt aggccaaaga atgacttggg acatcctttt     1620

tgcaataatt tgcgatctgg agattggatg attgattatg tcagtaatcg actgatttcg     1680

cgctcaggat ctattgctga agttggtaaa tggttccaag ctatgttctt ctatctaaag     1740

cagattccac gttaccttat cccttgttat tttgatgcta tattaattgg tgcgtacacc     1800

actcttctgg atatagcctg gaagcagatg tcaagctttg tccagaatgg ttcaacattt     1860

gtaaaacacc tgtcattggg ttcagttcaa atgtgcggga taggaaagtt cccatctctg     1920

ccttttcttt ctccatcact tggtgatgtt ccctatagac tgaatgaaat tacacaggaa     1980

aaggaacagt gctgtgtttc tctagctgct gggttacctc atttttcatc tggaattttt     2040

cgctgctggg gaagagatac cttcatagca cttagaggtc tactgctaat tactggtcgc     2100

tttttagagg caaggaacat aattctagca tttgctggta ctctgagaca tggtcttatt     2160

cccaatcttc tcggccaggg gacgtatgcc agattcaatt gtcgagatgc agtgtggtgg     2220

tggcttcagt gtattcagga ttactgtaaa attgttccaa agggcacgga cattctcaag     2280

tgccccgtat ccagaatgta tccatcagat gactcttctg ctctaccagc cggcacattg     2340

gatcagccat tgtatgaagt aatacaggaa gctatgcagc gtcatatgca aggcatacag     2400

ttccgagaaa agaatgctgg tccacagatt gaccggaata tgaaggatga aggttttaat     2460

gtcactgcag gagttgatga tgaaagtggg tttgtttatg gaggcaatca cttcaactgt     2520

ggaacatgga tggataaaat gggagagagt gacagaggtc gcaacagagg aatcccagct     2580

acacccagag atgggtctgc tgtggaaatt gttggcctga gtaaatcaac tgttcgctgg     2640

ttggtagaat tatcgaaaaa aaatgtgttc ccttatcacg gagttacagt aaagagaaat     2700

gaaaaagagg tattaatcac atacgatgaa tggaacagga aaatccaaga ccactttgaa     2760

aagctattct atgtttcaga ggatccatca gatactaatg aaaagcatcc taatttggtt     2820

cataagcgtg gtatatacaa agatagctat ggagcttcaa gtccttggtg tgactaccag     2880

ctcaggccaa actttaccat agcaatggtt gtggctcctg aactctttac tcctcagaag     2940

gcatggaaag ctttggaaat agcagagaag aaattgcttg gtcccctggg catgaaaact     3000

ctggatccag atgatatggt gtactgtgga gtatatgata atgccctaga caatgacaac     3060

tacaaccttg ctaaaggttt taattaccac caaggacctg aatggttgtg gcctgttgga     3120

tattttcttc gtgcaaagtt atatttttcc aagttaatgg gtcaggaaac ttacacaaag     3180

actgtgtttt tgattaaaaa tgttctttcc cgtcattacg tccatcttga gagatcccct     3240

tggaaagggc ttccagagct gactaatgaa aatggacaat actgttcttt cagctgtgaa     3300

acacaggctt ggtcaattgc cgttattctt gaaactcttt atgatttatg a              3351


<210>  36
<211>  3915
<212>  DNA
<213>  Anas platyrhynchos

<400>  36
atgcatccag aatgtggcta taaccttgta aattcccctc acctgaagcc agcttgggtc       60

ttagatagag ctctgtggca cttgacctgt atggtggctg atggaaagtg tattgataaa      120

ggggtccctc cgttgattga aaatgatcac cacctgaatt gtgtccgtaa aataatttgg      180

gaagagatat atccaaaaat taaactgtgg gaatttttcc aagtggatgt taataaagct      240

gtggaacaat ttagaaccct tctaactcaa ggtaaagaaa gcaaaatgag cactaaatct      300

gatccaaatc aacatcttca gatagttcag gaccctgagt atagacgatt tggctgtact      360

gtagatatga atatagcatt ggcaaccttc ataccgcaca gcaatggacc aggtgcaata      420

gaagagtgtt gtaactggtt tcgcaagagg attgaggaac tgaatgctga gcaacacaga      480

cagattcatc accatcaaga gcaggcagtc aactgtcttg cggggactgt ggtttatgaa      540

cgactggctg gtcatggtcc taaactgggt cctattagta gaaaatatcc tttagttacc      600

aggtatttta cttacccatt caaagacatg actgtggagg aagaagaagc tatgatacat      660

cgcccagata aagcttgcta tttcatggcc cataatggat gggttatggg cgatgatcct      720

cttagaaact ttgcagaacc aggttcaaat gtttacttga gaagggagct tatttgctgg      780

ggagacagtg tgaaactgcg ttatgggaac aaacctgaag actgcccata cctctgggca      840

catatgaaaa aatacacaga aatcacagcc aaatatttcc atggcgttcg tcttgacaac      900

tgtcactcaa cacctattca tgtagctgag tacatgctgg acacagctag aaaattgcga      960

gcagatttgt ttgtagtggc tgaactgttc acaggaaatg aggagctgga caatatcttt     1020

gtgaataggc tgggcattac ctccttaata agagaggcaa tgacagctta taatagccat     1080

gaggagggaa ggttagttta tcgttttgga ggtgaacctg ttggctcttt tgttcagcca     1140

cgtttgagac ccctgatgcc agctattgct catgcactgt tcatggatat tacacatgat     1200

aatgagtgtc cgatccagca ccgatctgca tatgatgctc ttcccagtgc aatgattgtt     1260

tccatggcat gctgtgctac aggtagcacc aaaggttatg atgaacttgt accacaccag     1320

atatccgtag tatccgaaga gagattttat tcaacatgga atccagcagc acacctgact     1380

tctggtgaag ttaatttcca aacaggaatt ctagcaggaa ggctggccat aaacaggctg     1440

catcaggagc tgggagctaa aggttttaat caggtgtatg tagatcaagt tgatgaagat     1500

atagtggcag tgacaagaca ttgccctaat acacaccagt ctgttgtggc tgtaagtaga     1560

actgctttca gagatccaaa gacttccttc tacagtaaag aagtgcctga aatgtgtatc     1620

ccagggaaaa ttgaagaagt agtacttgag gctagaacca ttgagagaaa tactaatcct     1680

tacaaaaaag atgaacgttt tataaatgga ttgcctaact tcacagtgga actcagagag     1740

cacattcaga ttaaagacag taaaattata aagcaagctg gaactgccat aaaagggcca     1800

aatgaatttg ttcaagaaat agaatttgaa aatttaacac caggaagtgt aatagtattc     1860

agagttagtc ttgatccaaa ggcacaagag gctgttggtg tactccgtag tcatctgatc     1920

cagtttagtc ctcactttaa atctggaagt cttcctgatg atcattcagc acccatatta     1980

aaaacattat tttcttcaat tgcatctaaa ttaagtttgg ctgacctaaa tcaagtgctg     2040

tataggtgtg aggcagaaga acaagaagat ggtggaggct gttacaatat accaaactgg     2100

tcaccgttga agtatgcagg cctccaaggg ttaatgtcag taatggcaga cattagacca     2160

aagaatgatt tgggccaccc gttttgtgat aatttaagat ctggagattg gatgattgat     2220

tatgtcagca atcgtctgat ttcacgtact ggagcctgtg cagaagttgg taaatggttg     2280

aaggccatgt ttatctattt aaagaaaatt ccacgttacc ttatcccatg ttattttgat     2340

gccatattag tgggtgcata cacaacgctt ctggatgtgg gatggcatca gatgtctagc     2400

tttgtgcaga acggatcaac atttgttaaa cacctttcct tgggctcaat ccagatgtgt     2460

gggataggaa aatactcatg tttgcccgat ctgtctcctt ccttacatga tgttccctat     2520

agactgaatg agattacaaa tgagaaagaa cagtgttgtg tttctttggc agctggttta     2580

cctcactttt cttcagggat ttttcgctct tggggaaggg atacctttat tgcactgaga     2640

ggtctgatgt tagttacagg gcgttatcta gaagcaagaa acataatttt agcatttggt     2700

gggactttaa gacatggtct cattcccaac ctgctcggcc aggggacgca tgccagatac     2760

aactgtcgtg atgctgtatg gtggtggctt cagtgtatcc aggactactg taaaattgtt     2820

ccaaatggat tagacattct cagatgtcct gtttccagaa tgtacccaag agatgactct     2880

tctcctcaac ctgcaggcag tgtggatcag ccgctttatg aagtaataca ggaagcaatg     2940

caacgacaca tggaaggcat aaatttccga gaaaggaatg ccggcccaca gatagatcaa     3000

aacatgagag atgaaggttt taatgtaaca gcgggtgttg accgtgaaac tggctttgtc     3060

ttcggaggga accgtttcaa ttgtggcacc tggatggata aaatggggga gagtgacaga     3120

gctcgcaaca gaggaattcc tgctactccg agagatggct ctgctgtgga aattgttggc     3180

ttgtgcaagt caactgtacg ctggcttctg gatttgtcta ggaaaaatga gtttccattc     3240

catggagtca ccataaaaag acacggaaag gaggaaacta tcacatatga tgaatgggac     3300

agaaaaattc aagcacactt tgaaaagctc ttctttgtct ctgagaaccc agcagatcca     3360

aatgaaaaac atccaaatct tgttcacaaa cgtggaatct ataaagacag ctatggagct     3420

tcaagtccat ggtgtgatta ccaactcaga ccaaatttta caatagcaat ggttgtggca     3480

cctgagttgt tcacacctga gagagcttgg aaagctctgc agatagcaga ggaaaaacta     3540

cttggtccgt taggcatgaa aactttagac ccagatgata tggtgtactg tggagtatat     3600

gataatgctc ttgacaatga caactataat gtagccagag gttttaatta tcaccaagga     3660

cctgaatggc tgtggccaat tggatatttc cttcgtgcca aattgtactt ctcaaagcta     3720

attggtccac agatatacgc aaaaactgta gttatgataa agaatgtgct ttctcgccac     3780

tatgttcacc ttgaaaggtc atcctggaaa gggcttccag agctgaccaa tgaaaatgga     3840

caatattgcc ctttcagctg tgaaactcag gcctggtcaa ttagtgttat ccttgaaatc     3900

ctttatgatt tgtga                                                      3915


<210>  37
<211>  4599
<212>  DNA
<213>  Homo sapiens

<400>  37
atgggacaca gtaaacagat tcgaatttta cttctgaacg aaatggagaa actggaaaag       60

accctcttca gacttgaaca agggtatgag ctacagttcc gattaggccc aactttacag      120

ggaaaagcag ttaccgtgta tacaaattac ccatttcctg gagaaacatt taatagagaa      180

aaattccgtt ctctggattg ggaaaatcca acagaaagag aagatgattc tgataaatac      240

tgtaaactta atctgcaaca atctggttca tttcagtatt atttccttca aggaaatgag      300

aaaagtggtg gaggttacat agttgtggac cccattttac gtgttggtgc tgataatcat      360

gtgctaccct tggactgtgt tactcttcag acatttttag ctaagtgttt gggacctttt      420

gatgaatggg aaagcagact tagggttgca aaagaatcag gctacaacat gattcatttt      480

accccattgc agactcttgg actatctagg tcatgctact cccttgccaa tcagttagaa      540

ttaaatcctg acttttcaag acctaataga aagtatacct ggaatgatgt tggacagcta      600

gtggaaaaat taaaaaagga atggaatgtt atttgtatta ctgatgttgt ctacaatcat      660

actgctgcta atagtaaatg gatccaggaa catccagaat gtgcctataa tcttgtaaat      720

tctccacact taaaacctgc ctgggtctta gacagagcac tttggcgttt ctcctgtgat      780

gttgcagaag ggaaatacaa agaaaaggga atacctgctt tgattgaaaa tgatcaccat      840

atgaactcca tccgaaaaat aatttgggag gatatttttc caaagcttaa actctgggaa      900

tttttccaag tagatgtcaa caaagcggtt gagcaattta gaagacttct tacacaagaa      960

aataggcgag taaccaagtc tgatccaaac caacacctta cgattattca agatcctgaa     1020

tacagacggt ttggctgtac tgtagatatg aacattgcac taacgacttt cataccacat     1080

gacaaggggc cagcagcaat tgaagaatgc tgtaattggt ttcataaaag aatggaggaa     1140

ttaaattcag agaagcatcg actcattaac tatcatcagg aacaggcagt taattgcctt     1200

ttgggaaatg tgttttatga acgactggct ggccatggtc caaaactagg acctgtcact     1260

agaaagcatc ctttagttac caggtatttt actttcccat ttgaagagat agacttctcc     1320

atggaagaat ctatgattca tctgccaaat aaagcttgtt ttctgatggc acacaatgga     1380

tgggtaatgg gagatgatcc tcttcgaaac tttgctgaac cgggttcaga agtttaccta     1440

aggagagaac ttatttgctg gggagacagt gttaaattac gctatgggaa taaaccagag     1500

gactgtcctt atctctgggc acacatgaaa aaatacactg aaataactgc aacttatttc     1560

cagggagtac gtcttgataa ctgccactca acacctcttc acgtagctga gtacatgttg     1620

gatgctgcta ggaatttgca acccaattta tatgtagtag ctgaactgtt cacaggaagt     1680

gaggacctag acaatgtctt tgttactaga ctgggcatta gttccttaat aagagaggca     1740

atgagtgcat ataatagtca tgaagagggc agattagttt accgatatgg aggagaacct     1800

gttggatcct ttgttcagcc ctgtttgagg cctttaatgc cagctattgc acatgccctg     1860

tttatggata ttacgcatga taatgagtgt cctattgtgc atagatcagc gtatgatgct     1920

cttccaagta ctacaattgt ttctatggca tgttgtgcta gtggaagtac aagaggctat     1980

gatgaattag tgcctcatca gatttcagtg gtttctgaag aacggtttta cactaagtgg     2040

aatcctgaag cattgccttc aaacacaggt gaagttaatt tccaaagcgg cattattgca     2100

gccaggtgtg ctatcagtaa acttcatcag gagcttggag ccaagggttt tattcaggtg     2160

tatgtggatc aagttgatga agacatagtg gcagtaacaa gacactcacc tagcatccat     2220

cagtctgttg tggctgtaac tagaactgct ttcaggaatc ccaagacttc attttacagc     2280

aaggaagtgc ctcaaatgtg catccctggc aaaattgaag aagtagttct tgaagctaga     2340

actattgaga gaaacacgaa accttatagg aaggatgaaa attcaatcaa tggaacacca     2400

gatatcacag tagaaattag agaacatatt cagcttaatg aaagtaaaat tgttaaacaa     2460

gctggagttg ccacaaaagg gcccaatgaa tatattcaag aaatagaatt tgaaaacttg     2520

tctccaggaa gtgttattat attcagagtt agtcttgatc cacatgcaca agtcgctgtt     2580

ggcattcttc gaaatcatct gacacaattc agtcctcact ttaaatctgg cagcctagct     2640

gttgacaatg cagatcctat attaaaaatt ccttttgctt ctcttgccta tagattaact     2700

ttggctgagc taaatcagat cctttaccga tgtgaatcag aagaaaagga agatggtgga     2760

gggtgctatg acataccaaa ctggtcagcc cttaaatatg caggtcttca aggtttaatg     2820

tctgtattgg cagaaataag accaaagaat gacttggggc atcctttttg taataatttg     2880

aggtctggag attggatgat tgactatgtc agtaaccggc ttatttcacg atcaggaact     2940

attgctgaag ttggtaaatg gttgcaggct atgttcttct acctgaagca gatcccacgt     3000

taccttatcc catgttactt tgatgctata ttaattggtg catataccac tcttctggat     3060

acagcatgga agcagatgtc aagctttgtt cagaatggtt caacctttgt gaaacacctt     3120

tcattgggtt cagttcaact gtgtggagta ggaaaattcc cttccctgcc aattctttca     3180

cctgccctaa tggatgtacc ttataggtta aatgagatca caaaagaaaa ggagcaatgt     3240

tgtgtttctc tagctgcagg cttacctcat ttttcttctg gtattttccg ctgctgggga     3300

agggatactt ttattgcact tagaggtata ctgctgatta ctggacgcta tgtagaagcc     3360

aggaatatta ttttagcatt tgcgggtacc ctgaggcatg gtctcattcc taatctactg     3420

ggtgaaggaa tttatgccag atacaattgt cgggatgctg tgtggtggtg gctgcagtgt     3480

atccaggatt actgtaaaat ggttccaaat ggactagaca ttctcaagtg cccagtttcc     3540

agaatgtatc ctacagatga ttctgctcct ttgcctgctg gcacactgga tcagccattg     3600

tttgaagtca tacaggaagc aatgcaaaaa cacatgcagg gcatacagtt ccgagaaagg     3660

aatgctggtc cccagataga tcgaaacatg aaggacgaag gttttaatat aactgcagga     3720

gttgatgaag aaacaggatt tgtttatgga ggaaatcgtt tcaattgtgg cacatggatg     3780

gataaaatgg gagaaagtga cagagctaga aacagaggaa tcccagccac accaagagat     3840

gggtctgctg tggaaattgt gggcctgagt aaatctgctg ttcgctggtt gctggaatta     3900

tccaaaaaaa atattttccc ttatcatgaa gtcacagtaa aaagacatgg aaaggctata     3960

aaggtctcat atgatgagtg gaacagaaaa atacaagaca actttgaaaa gctatttcat     4020

gtttccgaag acccttcaga tttaaatgaa aagcatccaa atctggttca caaacgtggc     4080

atatacaaag atagttatgg agcttcaagt ccttggtgtg actatcagct caggcctaat     4140

tttaccatag caatggttgt ggcccctgag ctctttacta cagaaaaagc atggaaagct     4200

ttggagattg cagaaaaaaa attgcttggt ccccttggca tgaaaacttt agatccagat     4260

gatatggttt actgtggaat ttatgacaac gcattagaca atgacaacta caatcttgct     4320

aaaggtttca attatcacca aggacctgag tggctgtggc ctattgggta ttttcttcgt     4380

gcaaaattat atttttccag attgatgggc ccggagacta ctgcaaagac tatagttttg     4440

gttaaaaatg ttctttcccg acattatgtt catcttgaga gatccccttg gaaaggactt     4500

ccagaactga ccaatgagaa tgcccagtac tgtcctttca gctgtgaaac acaagcctgg     4560

tcaattgcta ctattcttga gacactttat gatttatag                            4599


<210>  38
<211>  4599
<212>  DNA
<213>  artificial

<220>
<223>  hGDE co1

<400>  38
atgggccata gtaaacagat tcgcatactc ctcttgaacg agatggagaa actggagaag       60

acattgtttc ggttggagca ggggtacgag ctccagtttc gcctgggacc gacgctccaa      120

ggcaaagctg tgactgtata cacgaactat ccattcccgg gggagacgtt taacagggag      180

aagtttaggt ccctggactg ggagaaccca accgaacgag aggacgattc cgataaatat      240

tgcaagctca acttgcagca aagtggcagc tttcaatatt actttctcca aggcaatgag      300

aaaagtgggg gggggtatat tgttgtcgat ccaatactgc gcgtaggggc agataatcac      360

gttctcccgc tggattgcgt cactctccag acattcttgg ctaaatgctt ggggccgttt      420

gatgaatggg agtctcgctt gcgagtggcc aaagagtcag gttataacat gattcacttc      480

acaccactcc agacattggg acttagtcgg agctgttact cactcgcaaa tcaattggag      540

cttaacccag acttcagtcg gccaaatcgg aagtacacgt ggaacgacgt tggacaactt      600

gtcgaaaagt tgaagaaaga gtggaatgtg atttgcatca ctgacgtggt gtacaatcac      660

accgcagcca acagcaagtg gattcaggag cacccagagt gtgcgtacaa cctggtgaac      720

tcacctcacc tcaaacccgc ctgggtgctc gatagggctt tgtggcgctt ttcttgcgac      780

gtagcggaag gaaagtataa agagaaagga atacccgccc tcatagaaaa cgatcatcac      840

atgaattcta tacggaaaat catctgggag gatatatttc cgaaacttaa actttgggag      900

ttctttcaag tagatgtaaa caaggcggtg gagcaattca ggaggctcct cacccaagag      960

aatcgccggg ttactaaatc tgacccgaat caacacctta caataatcca agatccggaa     1020

tacaggaggt ttggttgcac tgtcgatatg aatattgcgc ttactacgtt catcccccac     1080

gacaagggcc cggccgcaat agaagaatgc tgcaattggt tccacaagcg gatggaagaa     1140

ctgaactctg aaaagcaccg ccttataaat tatcaccaag agcaggctgt gaactgtctg     1200

ctcggtaacg ttttttacga gcgcctggcc ggacacggac ctaaactcgg gccagtcact     1260

cgaaaacacc cactggttac gcgatacttc acattcccgt tcgaggagat cgacttttct     1320

atggaggaat ctatgatcca cctcccaaat aaagcttgtt ttcttatggc gcacaacgga     1380

tgggttatgg gggacgaccc actgcgaaac ttcgcagaac cgggtagtga ggtctacctt     1440

aggcgcgagc tcatttgttg gggcgacagc gtcaagctcc ggtatggaaa taagccagag     1500

gattgccctt acttgtgggc acacatgaag aagtatacgg aaataacagc tacctacttc     1560

cagggggtac gactggataa ctgccactcc acaccgttgc acgtggccga gtatatgctc     1620

gacgctgcgc gcaatttgca gccaaatctg tacgtcgtgg cagagctttt cactggaagt     1680

gaggacttgg ataacgtctt tgtgactcgc ctgggaatta gtagcttgat aagggaggct     1740

atgtccgcgt acaacagtca cgaggaagga cgattggttt atcgatatgg gggcgagcct     1800

gtaggctcct ttgtgcaacc ctgcttgcgg ccccttatgc ccgctatagc acacgcgctc     1860

ttcatggata tcacgcacga taatgaatgc cccatagtac acagatccgc ctacgacgcc     1920

cttccatcta cgacaatcgt ctctatggcc tgctgcgcct ccggcagcac tagaggctac     1980

gacgaactcg tcccacacca gatttcagtg gtatcagagg aacggtttta cactaaatgg     2040

aaccctgagg cgctcccatc taatactggc gaagtaaatt tccagtccgg aatcattgcg     2100

gcccgctgtg ctatctccaa gttgcatcag gaacttggag ctaaaggttt cattcaagta     2160

tatgtcgatc aggtcgatga agatattgtg gctgtgaccc gacactcccc atcaattcat     2220

caaagtgtag tggctgtaac tcggacggct tttcgcaacc caaagacttc attctactcc     2280

aaagaggttc cacagatgtg tattccggga aagatagaag aagtggtatt ggaagcccgg     2340

accatcgaga ggaacactaa accatatcga aaagacgaga actccattaa cggaacccct     2400

gacatcactg ttgagatccg cgagcatatt cagcttaacg aaagcaaaat cgttaagcag     2460

gccggcgttg ccactaaggg accaaacgaa tatatccaag aaatcgaatt cgaaaacctc     2520

agtcctggct ccgttattat ctttcgcgta tccctcgacc cacacgccca agttgcggta     2580

gggatcttga gaaaccacct cacacagttc agcccacact ttaaatcagg ctccctcgcc     2640

gttgataacg cggacccaat acttaagatc ccctttgcat cccttgcgta tcgacttact     2700

ctcgcagagc ttaatcaaat attgtaccgc tgcgagtccg aagagaagga agacggtggt     2760

ggctgctacg acatccctaa ttggagtgca cttaagtacg cggggctgca gggactgatg     2820

tcagtgcttg cagagataag gccgaagaat gaccttggcc atccattttg taataatctc     2880

cgaagtggtg attggatgat agattacgta tcaaaccgct tgatcagtcg gtctggtacc     2940

atcgcggaag tgggaaagtg gttgcaggca atgttctttt atctcaaaca aatcccacgg     3000

tacttgatac cttgctattt cgacgcaatt ctcatcggtg catacacgac cttgctggac     3060

acggcctgga agcagatgtc tagcttcgtt cagaacggtt ctaccttcgt aaagcacctc     3120

tcattgggtt cagtccaact ctgcggagtc gggaaattcc cttcacttcc tattctctca     3180

cctgccctca tggacgtgcc ctaccggctg aacgaaatta ctaaggagaa ggaacagtgt     3240

tgtgtttctt tggcggcagg cttgccgcac ttttccagtg gaatcttcag atgttgggga     3300

cgggacacat tcattgcgct ccggggtatt ttgttgataa cgggccgata cgttgaggca     3360

cgaaatatta ttctggcatt cgccgggacc ttgcggcacg ggctgatacc caacctgctg     3420

ggcgaaggga tttacgctcg ctataactgc cgagacgcag tttggtggtg gctgcagtgt     3480

attcaggact attgtaagat ggtaccgaac gggctcgaca tcttgaagtg tcccgttagt     3540

cgaatgtatc ccaccgacga ttcagctccc ctgcccgcgg gaacacttga ccaaccactc     3600

tttgaagtga tccaagaggc tatgcagaaa cacatgcagg gaatacagtt ccgagaacga     3660

aacgcagggc cgcagattga tcgaaatatg aaagacgaag gatttaatat cacggcaggg     3720

gtcgacgaag agacggggtt tgtctacggc gggaatagat ttaactgcgg cacctggatg     3780

gataaaatgg gagaaagtga ccgagcacgg aaccggggca taccagcaac cccccgagac     3840

gggagcgctg ttgagatcgt gggtctgtct aagagtgcgg ttcgctggct tctcgagctt     3900

tcaaaaaaaa atatatttcc ttaccacgag gtcacggtca aaaggcatgg aaaagccata     3960

aaagtgtcat acgacgagtg gaataggaaa atacaagata actttgaaaa gctgtttcac     4020

gttagcgaag atcccagcga tctcaacgaa aaacatccca atctggttca caaacgcggg     4080

atctataaag actcatatgg agctagttct ccttggtgcg attatcaact gagaccgaac     4140

tttacaatcg ccatggtagt tgcgcccgag ctctttacta cagaaaaagc ctggaaggca     4200

cttgagattg cggaaaagaa actgcttggc cctctcggga tgaaaacgct tgatcccgac     4260

gacatggtct attgcgggat ttacgacaac gcattggaca acgacaacta caacttggcg     4320

aaaggattta attatcacca gggtcctgag tggttgtggc ccattggata ctttcttcga     4380

gcgaagctgt atttttcaag gctgatgggg ccggaaacga cagcgaaaac tattgtgctt     4440

gtcaaaaacg tgcttagcag gcattacgtg cacctcgagc gcagcccttg gaaaggactt     4500

ccggagctta cgaacgaaaa cgcccagtat tgtccattta gctgtgagac gcaggcctgg     4560

tctattgcta ccatcctcga gacactctac gacttgtag                            4599


<210>  39
<211>  4599
<212>  DNA
<213>  artificial

<220>
<223>  hGDE co2

<400>  39
atgggccaca gcaagcagat cagaatcctg ctgctgaacg agatggaaaa gctggaaaag       60

accctgttcc ggctcgagca gggctacgag ctgcagttta gactgggccc tacactgcag      120

ggcaaagccg tgaccgtgta cacaaactac cccttccctg gcgaaacctt caaccgcgag      180

aagttcagaa gcctggactg ggagaacccc accgagagag aggacgacag cgacaagtac      240

tgcaagctga acctgcagca gagcggctcc ttccagtact acttcctgca aggcaacgag      300

aagtccggcg gaggctacat cgtggtggac cctattctga gagtgggcgc cgacaatcac      360

gtgctgcctc tggattgtgt gaccctgcag accttcctgg ccaagtgtct gggccctttc      420

gatgagtggg agagcagact gcgcgtggcc aaagaaagcg gctacaacat gatccacttc      480

acccctctgc agaccctggg cctgagcaga agctgttaca gcctggccaa ccagctggaa      540

ctgaaccccg acttcagcag acccaaccgg aagtacacct ggaacgatgt gggccagctg      600

gtggaaaaac tgaagaaaga atggaacgtg atctgcatca ccgacgtggt gtacaaccac      660

accgccgcca acagcaagtg gatccaagag caccctgagt gcgcctacaa cctggtcaac      720

agccctcacc tgaaacctgc ctgggtgctc gatagagccc tgtggcggtt tagctgtgat      780

gtggccgagg gcaagtacaa agagaagggc atccccgctc tgatcgagaa cgaccaccac      840

atgaacagca tccggaagat catctgggaa gatattttcc ccaagctgaa gctgtgggag      900

ttcttccagg tggacgtgaa caaggccgtg gaacagttca gacggctgct gacccaagag      960

aacagaagag tgaccaagag cgaccccaac cagcacctga ccatcattca ggaccccgag     1020

tatcggagat tcggctgcac cgtggacatg aatatcgccc tgaccacctt cattccccac     1080

gacaaaggac ctgccgccat cgaggaatgc tgcaactggt tccacaagcg gatggaagaa     1140

ttgaacagcg agaagcaccg gctgatcaac taccaccaag agcaggccgt gaactgcctg     1200

ctgggcaacg tgttctatga gagactggcc ggacacggcc ctaagctggg acctgtgaca     1260

agaaagcacc ctctggttac ccggtacttc acctttccat tcgaagagat cgacttctcc     1320

atggaagaga gcatgatcca tctgcctaac aaggcctgct tcctgatggc tcacaacggc     1380

tgggttatgg gcgacgaccc tctgagaaat ttcgccgagc ctggcagcga ggtgtacctg     1440

agaagagaac tgatctgttg gggcgacagc gtgaagctga gatacggcaa caagcccgag     1500

gactgccctt acctgtgggc ccatatgaag aagtacacag agatcaccgc cacctacttt     1560

cagggcgtca gactggacaa ctgccacagc acacctctgc acgtggccga gtacatgctg     1620

gacgccgcta gaaatctgca gcccaacctg tatgtggtgg ccgagctgtt taccggctcc     1680

gaggacctgg acaatgtgtt cgtgaccaga ctgggcatca gcagcctgat cagagaagcc     1740

atgtccgcct acaatagcca cgaagagggc agactggtgt acagatatgg cggcgagcct     1800

gtgggcagct tcgttcagcc ttgtctgagg cctctgatgc ccgccattgc tcacgccctg     1860

ttcatggaca tcacccacga taacgagtgc cccatcgtgc acagaagcgc ctacgacgct     1920

ctgcctagca ccaccattgt gtccatggcc tgttgtgcca gcggcagcac aagaggctat     1980

gacgaactgg tgccccacca gatttccgtg gtgtccgagg aacggttcta caccaagtgg     2040

aaccccgagg ctctgcccag caataccggc gaagtgaatt tccagagcgg catcattgcc     2100

gccagatgcg ccatcagcaa gctgcaccaa gaactgggcg ccaagggctt cattcaggtg     2160

tacgtggacc aggtcgacga ggacattgtg gccgtgacaa gacacagccc cagcatccat     2220

cagagcgtgg tggctgtgac cagaaccgcc ttcagaaacc ccaagaccag cttctacagc     2280

aaagaggtgc cccagatgtg catccccggc aagattgagg aagtggtgct cgaggcccgg     2340

accatcgaga gaaacaccaa gccttaccgg aaggacgaga actccatcaa cggcacccct     2400

gacatcaccg tggaaatcag agagcacatc cagctcaacg agagcaagat cgtgaaacag     2460

gccggcgtgg ccacaaaggg ccccaacgag tatatccaag agattgagtt cgagaatctg     2520

agccccggca gcgtgatcat cttcagagtg tccctggatc ctcacgctca ggtggccgtg     2580

ggcatcctga gaaatcacct gacacagttc agcccacact tcaagagcgg aagcctggcc     2640

gtggacaacg ccgatcctat cctgaagatc cccttcgcct ctctggccta cagactgaca     2700

ctggctgagc tgaaccagat cctgtacaga tgcgagtccg aagagaaaga ggatggcgga     2760

ggctgctacg acatccccaa ttggagcgcc ctgaagtatg ccggactgca gggactgatg     2820

tctgtgctgg ccgagatcag acccaagaac gacctgggac accccttctg caacaacctg     2880

agatccggcg actggatgat cgactacgtg tccaacagac tgatcagcag atccggcaca     2940

atcgccgaag tcggcaaatg gctgcaggcc atgttcttct acctgaagca gatccctcgg     3000

tatctgatcc cctgctactt cgacgccatc ctgatcggcg cctacaccac actgctggat     3060

accgcctgga agcagatgtc cagcttcgtg cagaacggca gcaccttcgt gaagcacctg     3120

tctctgggaa gcgtgcagct gtgtggcgtg ggcaaatttc ccagcctgcc tatcctgtct     3180

cctgcactga tggacgtgcc ctaccggctg aatgagatca ccaaagaaaa agagcagtgc     3240

tgcgtcagcc tggctgctgg cctgcctcat ttttccagcg gcatcttccg gtgttggggc     3300

agagacacct ttattgccct gagaggcatc ctgctgatta ccggcagata cgtggaagcc     3360

cggaacatca tcctggcctt tgccggcaca ctgcggcacg gactgattcc taatctgctc     3420

ggcgagggca tctacgccag atacaactgc agagatgccg tgtggtggtg gctccagtgc     3480

atccaggact actgcaagat ggtgcccaac ggcctggaca tcctgaagtg ccctgtgtcc     3540

agaatgtacc ctaccgacga tagcgcccct ctgcctgccg gaacacttga ccagcctctg     3600

ttcgaagtga ttcaagaggc catgcagaaa cacatgcagg gaatccagtt tcgcgagcgg     3660

aatgccggac ctcagatcga cagaaacatg aaggatgagg gcttcaacat caccgctggc     3720

gtggacgaag agacaggctt tgtgtacggc ggcaaccggt tcaattgcgg cacctggatg     3780

gacaagatgg gcgagtctga ccgggccaga aacagaggaa ttcccgccac acctagagat     3840

ggcagcgctg tggaaatcgt gggcctgtct aagtctgctg tgcggtggct gctcgaactg     3900

agcaagaaga atatctttcc gtaccacgaa gtgaccgtga agcggcacgg caaggccatc     3960

aaggtgtcct acgacgagtg gaacagaaag atccaggaca acttcgaaaa gctgttccat     4020

gtgtctgagg accccagcga cctgaacgaa aagcacccca acctggtgca caagcgcggc     4080

atctacaagg acagctacgg cgcctcttct ccttggtgcg attaccagct gcggcccaac     4140

ttcaccattg ccatggtggt tgcccctgag ctgttcacca cagagaaggc ctggaaggcc     4200

ctggaaatcg ccgagaagaa actgctgggc cctctgggca tgaagacact ggaccccgac     4260

gacatggtgt actgcggaat ctacgacaac gccctggata acgacaacta caatctggcc     4320

aaggggttca attaccatca gggacccgag tggctgtggc ctatcggcta tttcctgcgg     4380

gccaagctgt acttctccag actgatgggc cctgagacaa ccgccaagac aatcgtgctc     4440

gtgaagaacg tgctgagccg gcactatgtg cacctggaaa gaagcccctg gaagggactg     4500

cccgagctga ccaatgagaa cgcccagtac tgccccttca gctgcgaaac acaggcctgg     4560

tctatcgcca ccatcctgga aaccctgtac gacctgtga                            4599


<210>  40
<211>  1515
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Leu Leu Thr Cys Ala Phe Tyr Leu Gly Tyr Glu Leu Gln Phe 
1               5                   10                  15      


Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val Tyr Thr Asn 
            20                  25                  30          


Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser Leu 
        35                  40                  45              


Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp Lys Tyr Cys 
    50                  55                  60                  


Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu Gln 
65                  70                  75                  80  


Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile Leu 
                85                  90                  95      


Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr Leu 
            100                 105                 110         


Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu Ser 
        115                 120                 125             


Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe Thr 
    130                 135                 140                 


Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala Asn 
145                 150                 155                 160 


Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr Thr 
                165                 170                 175     


Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp Asn 
            180                 185                 190         


Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn Ser 
        195                 200                 205             


Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn Ser 
    210                 215                 220                 


Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg Phe 
225                 230                 235                 240 


Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro Ala 
                245                 250                 255     


Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile Trp 
            260                 265                 270         


Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val Asp 
        275                 280                 285             


Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu Asn 
    290                 295                 300                 


Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile Gln 
305                 310                 315                 320 


Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile Ala 
                325                 330                 335     


Leu Thr Thr Phe Ile Pro His Asp Lys Gly Pro Ala Ala Ile Glu Glu 
            340                 345                 350         


Cys Cys Asn Trp Phe His Lys Arg Met Glu Glu Leu Asn Ser Glu Lys 
        355                 360                 365             


His Arg Leu Ile Asn Tyr His Gln Glu Gln Ala Val Asn Cys Leu Leu 
    370                 375                 380                 


Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His Gly Pro Lys Leu Gly 
385                 390                 395                 400 


Pro Val Thr Arg Lys His Pro Leu Val Thr Arg Tyr Phe Thr Phe Pro 
                405                 410                 415     


Phe Glu Glu Ile Asp Phe Ser Met Glu Glu Ser Met Ile His Leu Pro 
            420                 425                 430         


Asn Lys Ala Cys Phe Leu Met Ala His Asn Gly Trp Val Met Gly Asp 
        435                 440                 445             


Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu Arg 
    450                 455                 460                 


Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly Asn 
465                 470                 475                 480 


Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr Thr 
                485                 490                 495     


Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys His 
            500                 505                 510         


Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg Asn 
        515                 520                 525             


Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser Glu 
    530                 535                 540                 


Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu Ile 
545                 550                 555                 560 


Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu Val 
                565                 570                 575     


Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys Leu 
            580                 585                 590         


Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile Thr 
        595                 600                 605             


His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala Leu 
    610                 615                 620                 


Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser Thr 
625                 630                 635                 640 


Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile Ser Val Val Ser Glu 
                645                 650                 655     


Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu Ala Leu Pro Ser Asn Thr 
            660                 665                 670         


Gly Glu Val Asn Phe Gln Ser Gly Ile Ile Ala Ala Arg Cys Ala Ile 
        675                 680                 685             


Ser Lys Leu His Gln Glu Leu Gly Ala Lys Gly Phe Ile Gln Val Tyr 
    690                 695                 700                 


Val Asp Gln Val Asp Glu Asp Ile Val Ala Val Thr Arg His Ser Pro 
705                 710                 715                 720 


Ser Ile His Gln Ser Val Val Ala Val Thr Arg Thr Ala Phe Arg Asn 
                725                 730                 735     


Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val Pro Gln Met Cys Ile Pro 
            740                 745                 750         


Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg Thr Ile Glu Arg Asn 
        755                 760                 765             


Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro Asp 
    770                 775                 780                 


Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu Asn Glu Ser Lys Ile 
785                 790                 795                 800 


Val Lys Gln Ala Gly Val Ala Thr Lys Gly Pro Asn Glu Tyr Ile Gln 
                805                 810                 815     


Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly Ser Val Ile Ile Phe Arg 
            820                 825                 830         


Val Ser Leu Asp Pro His Ala Gln Val Ala Val Gly Ile Leu Arg Asn 
        835                 840                 845             


His Leu Thr Gln Phe Ser Pro His Phe Lys Ser Gly Ser Leu Ala Val 
    850                 855                 860                 


Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro Phe Ala Ser Leu Ala Tyr 
865                 870                 875                 880 


Arg Leu Thr Leu Ala Glu Leu Asn Gln Ile Leu Tyr Arg Cys Glu Ser 
                885                 890                 895     


Glu Glu Lys Glu Asp Gly Gly Gly Cys Tyr Asp Ile Pro Asn Trp Ser 
            900                 905                 910         


Ala Leu Lys Tyr Ala Gly Leu Gln Gly Leu Met Ser Val Leu Ala Glu 
        915                 920                 925             


Ile Arg Pro Lys Asn Asp Leu Gly His Pro Phe Cys Asn Asn Leu Arg 
    930                 935                 940                 


Ser Gly Asp Trp Met Ile Asp Tyr Val Ser Asn Arg Leu Ile Ser Arg 
945                 950                 955                 960 


Ser Gly Thr Ile Ala Glu Val Gly Lys Trp Leu Gln Ala Met Phe Phe 
                965                 970                 975     


Tyr Leu Lys Gln Ile Pro Arg Tyr Leu Ile Pro Cys Tyr Phe Asp Ala 
            980                 985                 990         


Ile Leu Ile Gly Ala Tyr Thr Thr  Leu Leu Asp Thr Ala  Trp Lys Gln 
        995                 1000                 1005             


Met Ser  Ser Phe Val Gln Asn  Gly Ser Thr Phe Val  Lys His Leu 
    1010                 1015                 1020             


Ser Leu  Gly Ser Val Gln Leu  Cys Gly Val Gly Lys  Phe Pro Ser 
    1025                 1030                 1035             


Leu Pro  Ile Leu Ser Pro Ala  Leu Met Asp Val Pro  Tyr Arg Leu 
    1040                 1045                 1050             


Asn Glu  Ile Thr Lys Glu Lys  Glu Gln Cys Cys Val  Ser Leu Ala 
    1055                 1060                 1065             


Ala Gly  Leu Pro His Phe Ser  Ser Gly Ile Phe Arg  Cys Trp Gly 
    1070                 1075                 1080             


Arg Asp  Thr Phe Ile Ala Leu  Arg Gly Ile Leu Leu  Ile Thr Gly 
    1085                 1090                 1095             


Arg Tyr  Val Glu Ala Arg Asn  Ile Ile Leu Ala Phe  Ala Gly Thr 
    1100                 1105                 1110             


Leu Arg  His Gly Leu Ile Pro  Asn Leu Leu Gly Glu  Gly Ile Tyr 
    1115                 1120                 1125             


Ala Arg  Tyr Asn Cys Arg Asp  Ala Val Trp Trp Trp  Leu Gln Cys 
    1130                 1135                 1140             


Ile Gln  Asp Tyr Cys Lys Met  Val Pro Asn Gly Leu  Asp Ile Leu 
    1145                 1150                 1155             


Lys Cys  Pro Val Ser Arg Met  Tyr Pro Thr Asp Asp  Ser Ala Pro 
    1160                 1165                 1170             


Leu Pro  Ala Gly Thr Leu Asp  Gln Pro Leu Phe Glu  Val Ile Gln 
    1175                 1180                 1185             


Glu Ala  Met Gln Lys His Met  Gln Gly Ile Gln Phe  Arg Glu Arg 
    1190                 1195                 1200             


Asn Ala  Gly Pro Gln Ile Asp  Arg Asn Met Lys Asp  Glu Gly Phe 
    1205                 1210                 1215             


Asn Ile  Thr Ala Gly Val Asp  Glu Glu Thr Gly Phe  Val Tyr Gly 
    1220                 1225                 1230             


Gly Asn  Arg Phe Asn Cys Gly  Thr Trp Met Asp Lys  Met Gly Glu 
    1235                 1240                 1245             


Ser Asp  Arg Ala Arg Asn Arg  Gly Ile Pro Ala Thr  Pro Arg Asp 
    1250                 1255                 1260             


Gly Ser  Ala Val Glu Ile Val  Gly Leu Ser Lys Ser  Ala Val Arg 
    1265                 1270                 1275             


Trp Leu  Leu Glu Leu Ser Lys  Lys Asn Ile Phe Pro  Tyr His Glu 
    1280                 1285                 1290             


Val Thr  Val Lys Arg His Gly  Lys Ala Ile Lys Val  Ser Tyr Asp 
    1295                 1300                 1305             


Glu Trp  Asn Arg Lys Ile Gln  Asp Asn Phe Glu Lys  Leu Phe His 
    1310                 1315                 1320             


Val Ser  Glu Asp Pro Ser Asp  Leu Asn Glu Lys His  Pro Asn Leu 
    1325                 1330                 1335             


Val His  Lys Arg Gly Ile Tyr  Lys Asp Ser Tyr Gly  Ala Ser Ser 
    1340                 1345                 1350             


Pro Trp  Cys Asp Tyr Gln Leu  Arg Pro Asn Phe Thr  Ile Ala Met 
    1355                 1360                 1365             


Val Val  Ala Pro Glu Leu Phe  Thr Thr Glu Lys Ala  Trp Lys Ala 
    1370                 1375                 1380             


Leu Glu  Ile Ala Glu Lys Lys  Leu Leu Gly Pro Leu  Gly Met Lys 
    1385                 1390                 1395             


Thr Leu  Asp Pro Asp Asp Met  Val Tyr Cys Gly Ile  Tyr Asp Asn 
    1400                 1405                 1410             


Ala Leu  Asp Asn Asp Asn Tyr  Asn Leu Ala Lys Gly  Phe Asn Tyr 
    1415                 1420                 1425             


His Gln  Gly Pro Glu Trp Leu  Trp Pro Ile Gly Tyr  Phe Leu Arg 
    1430                 1435                 1440             


Ala Lys  Leu Tyr Phe Ser Arg  Leu Met Gly Pro Glu  Thr Thr Ala 
    1445                 1450                 1455             


Lys Thr  Ile Val Leu Val Lys  Asn Val Leu Ser Arg  His Tyr Val 
    1460                 1465                 1470             


His Leu  Glu Arg Ser Pro Trp  Lys Gly Leu Pro Glu  Leu Thr Asn 
    1475                 1480                 1485             


Glu Asn  Ala Gln Tyr Cys Pro  Phe Ser Cys Glu Thr  Gln Ala Trp 
    1490                 1495                 1500             


Ser Ile  Ala Thr Ile Leu Glu  Thr Leu Tyr Asp Leu  
    1505                 1510                 1515 


<210>  41
<211>  1516
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Pro Ile Leu Ser Ile Asn Leu Phe Ile Gly Tyr Glu Leu Gln 
1               5                   10                  15      


Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val Tyr Thr 
            20                  25                  30          


Asn Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser 
        35                  40                  45              


Leu Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp Lys Tyr 
    50                  55                  60                  


Cys Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu 
65                  70                  75                  80  


Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile 
                85                  90                  95      


Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr 
            100                 105                 110         


Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu 
        115                 120                 125             


Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe 
    130                 135                 140                 


Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala 
145                 150                 155                 160 


Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr 
                165                 170                 175     


Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp 
            180                 185                 190         


Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn 
        195                 200                 205             


Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn 
    210                 215                 220                 


Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg 
225                 230                 235                 240 


Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro 
                245                 250                 255     


Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile 
            260                 265                 270         


Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val 
        275                 280                 285             


Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu 
    290                 295                 300                 


Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile 
305                 310                 315                 320 


Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile 
                325                 330                 335     


Ala Leu Thr Thr Phe Ile Pro His Asp Lys Gly Pro Ala Ala Ile Glu 
            340                 345                 350         


Glu Cys Cys Asn Trp Phe His Lys Arg Met Glu Glu Leu Asn Ser Glu 
        355                 360                 365             


Lys His Arg Leu Ile Asn Tyr His Gln Glu Gln Ala Val Asn Cys Leu 
    370                 375                 380                 


Leu Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His Gly Pro Lys Leu 
385                 390                 395                 400 


Gly Pro Val Thr Arg Lys His Pro Leu Val Thr Arg Tyr Phe Thr Phe 
                405                 410                 415     


Pro Phe Glu Glu Ile Asp Phe Ser Met Glu Glu Ser Met Ile His Leu 
            420                 425                 430         


Pro Asn Lys Ala Cys Phe Leu Met Ala His Asn Gly Trp Val Met Gly 
        435                 440                 445             


Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu 
    450                 455                 460                 


Arg Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly 
465                 470                 475                 480 


Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr 
                485                 490                 495     


Thr Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys 
            500                 505                 510         


His Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg 
        515                 520                 525             


Asn Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser 
    530                 535                 540                 


Glu Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu 
545                 550                 555                 560 


Ile Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu 
                565                 570                 575     


Val Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys 
            580                 585                 590         


Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile 
        595                 600                 605             


Thr His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala 
    610                 615                 620                 


Leu Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser 
625                 630                 635                 640 


Thr Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile Ser Val Val Ser 
                645                 650                 655     


Glu Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu Ala Leu Pro Ser Asn 
            660                 665                 670         


Thr Gly Glu Val Asn Phe Gln Ser Gly Ile Ile Ala Ala Arg Cys Ala 
        675                 680                 685             


Ile Ser Lys Leu His Gln Glu Leu Gly Ala Lys Gly Phe Ile Gln Val 
    690                 695                 700                 


Tyr Val Asp Gln Val Asp Glu Asp Ile Val Ala Val Thr Arg His Ser 
705                 710                 715                 720 


Pro Ser Ile His Gln Ser Val Val Ala Val Thr Arg Thr Ala Phe Arg 
                725                 730                 735     


Asn Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val Pro Gln Met Cys Ile 
            740                 745                 750         


Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg Thr Ile Glu Arg 
        755                 760                 765             


Asn Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro 
    770                 775                 780                 


Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu Asn Glu Ser Lys 
785                 790                 795                 800 


Ile Val Lys Gln Ala Gly Val Ala Thr Lys Gly Pro Asn Glu Tyr Ile 
                805                 810                 815     


Gln Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly Ser Val Ile Ile Phe 
            820                 825                 830         


Arg Val Ser Leu Asp Pro His Ala Gln Val Ala Val Gly Ile Leu Arg 
        835                 840                 845             


Asn His Leu Thr Gln Phe Ser Pro His Phe Lys Ser Gly Ser Leu Ala 
    850                 855                 860                 


Val Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro Phe Ala Ser Leu Ala 
865                 870                 875                 880 


Tyr Arg Leu Thr Leu Ala Glu Leu Asn Gln Ile Leu Tyr Arg Cys Glu 
                885                 890                 895     


Ser Glu Glu Lys Glu Asp Gly Gly Gly Cys Tyr Asp Ile Pro Asn Trp 
            900                 905                 910         


Ser Ala Leu Lys Tyr Ala Gly Leu Gln Gly Leu Met Ser Val Leu Ala 
        915                 920                 925             


Glu Ile Arg Pro Lys Asn Asp Leu Gly His Pro Phe Cys Asn Asn Leu 
    930                 935                 940                 


Arg Ser Gly Asp Trp Met Ile Asp Tyr Val Ser Asn Arg Leu Ile Ser 
945                 950                 955                 960 


Arg Ser Gly Thr Ile Ala Glu Val Gly Lys Trp Leu Gln Ala Met Phe 
                965                 970                 975     


Phe Tyr Leu Lys Gln Ile Pro Arg Tyr Leu Ile Pro Cys Tyr Phe Asp 
            980                 985                 990         


Ala Ile Leu Ile Gly Ala Tyr Thr  Thr Leu Leu Asp Thr  Ala Trp Lys 
        995                 1000                 1005             


Gln Met  Ser Ser Phe Val Gln  Asn Gly Ser Thr Phe  Val Lys His 
    1010                 1015                 1020             


Leu Ser  Leu Gly Ser Val Gln  Leu Cys Gly Val Gly  Lys Phe Pro 
    1025                 1030                 1035             


Ser Leu  Pro Ile Leu Ser Pro  Ala Leu Met Asp Val  Pro Tyr Arg 
    1040                 1045                 1050             


Leu Asn  Glu Ile Thr Lys Glu  Lys Glu Gln Cys Cys  Val Ser Leu 
    1055                 1060                 1065             


Ala Ala  Gly Leu Pro His Phe  Ser Ser Gly Ile Phe  Arg Cys Trp 
    1070                 1075                 1080             


Gly Arg  Asp Thr Phe Ile Ala  Leu Arg Gly Ile Leu  Leu Ile Thr 
    1085                 1090                 1095             


Gly Arg  Tyr Val Glu Ala Arg  Asn Ile Ile Leu Ala  Phe Ala Gly 
    1100                 1105                 1110             


Thr Leu  Arg His Gly Leu Ile  Pro Asn Leu Leu Gly  Glu Gly Ile 
    1115                 1120                 1125             


Tyr Ala  Arg Tyr Asn Cys Arg  Asp Ala Val Trp Trp  Trp Leu Gln 
    1130                 1135                 1140             


Cys Ile  Gln Asp Tyr Cys Lys  Met Val Pro Asn Gly  Leu Asp Ile 
    1145                 1150                 1155             


Leu Lys  Cys Pro Val Ser Arg  Met Tyr Pro Thr Asp  Asp Ser Ala 
    1160                 1165                 1170             


Pro Leu  Pro Ala Gly Thr Leu  Asp Gln Pro Leu Phe  Glu Val Ile 
    1175                 1180                 1185             


Gln Glu  Ala Met Gln Lys His  Met Gln Gly Ile Gln  Phe Arg Glu 
    1190                 1195                 1200             


Arg Asn  Ala Gly Pro Gln Ile  Asp Arg Asn Met Lys  Asp Glu Gly 
    1205                 1210                 1215             


Phe Asn  Ile Thr Ala Gly Val  Asp Glu Glu Thr Gly  Phe Val Tyr 
    1220                 1225                 1230             


Gly Gly  Asn Arg Phe Asn Cys  Gly Thr Trp Met Asp  Lys Met Gly 
    1235                 1240                 1245             


Glu Ser  Asp Arg Ala Arg Asn  Arg Gly Ile Pro Ala  Thr Pro Arg 
    1250                 1255                 1260             


Asp Gly  Ser Ala Val Glu Ile  Val Gly Leu Ser Lys  Ser Ala Val 
    1265                 1270                 1275             


Arg Trp  Leu Leu Glu Leu Ser  Lys Lys Asn Ile Phe  Pro Tyr His 
    1280                 1285                 1290             


Glu Val  Thr Val Lys Arg His  Gly Lys Ala Ile Lys  Val Ser Tyr 
    1295                 1300                 1305             


Asp Glu  Trp Asn Arg Lys Ile  Gln Asp Asn Phe Glu  Lys Leu Phe 
    1310                 1315                 1320             


His Val  Ser Glu Asp Pro Ser  Asp Leu Asn Glu Lys  His Pro Asn 
    1325                 1330                 1335             


Leu Val  His Lys Arg Gly Ile  Tyr Lys Asp Ser Tyr  Gly Ala Ser 
    1340                 1345                 1350             


Ser Pro  Trp Cys Asp Tyr Gln  Leu Arg Pro Asn Phe  Thr Ile Ala 
    1355                 1360                 1365             


Met Val  Val Ala Pro Glu Leu  Phe Thr Thr Glu Lys  Ala Trp Lys 
    1370                 1375                 1380             


Ala Leu  Glu Ile Ala Glu Lys  Lys Leu Leu Gly Pro  Leu Gly Met 
    1385                 1390                 1395             


Lys Thr  Leu Asp Pro Asp Asp  Met Val Tyr Cys Gly  Ile Tyr Asp 
    1400                 1405                 1410             


Asn Ala  Leu Asp Asn Asp Asn  Tyr Asn Leu Ala Lys  Gly Phe Asn 
    1415                 1420                 1425             


Tyr His  Gln Gly Pro Glu Trp  Leu Trp Pro Ile Gly  Tyr Phe Leu 
    1430                 1435                 1440             


Arg Ala  Lys Leu Tyr Phe Ser  Arg Leu Met Gly Pro  Glu Thr Thr 
    1445                 1450                 1455             


Ala Lys  Thr Ile Val Leu Val  Lys Asn Val Leu Ser  Arg His Tyr 
    1460                 1465                 1470             


Val His  Leu Glu Arg Ser Pro  Trp Lys Gly Leu Pro  Glu Leu Thr 
    1475                 1480                 1485             


Asn Glu  Asn Ala Gln Tyr Cys  Pro Phe Ser Cys Glu  Thr Gln Ala 
    1490                 1495                 1500             


Trp Ser  Ile Ala Thr Ile Leu  Glu Thr Leu Tyr Asp  Leu 
    1505                 1510                 1515     


<210>  42
<211>  441
<212>  DNA
<213>  artificial

<220>
<223>  HBB2 intron

<400>  42
gtacacatat tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt       60

cttttaatat acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca      120

gggcaataat gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata      180

atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt      240

aactgatgta agaggtttca tattgctaat agcagctaca atccagctac cattctgctt      300

ttattttatg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa      360

tcatgttcat acctcttatc ttcctcccac agctcctggg caacgtgctg gtctgtgtgc      420

tggcccatca ctttggcaaa g                                                441


<210>  43
<211>  441
<212>  DNA
<213>  artificial

<220>
<223>  modified HBB2 intron

<400>  43
gtacacatat tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt       60

cttttaatat acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca      120

gggcaataat gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata      180

atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt      240

aactgatgta agaggtttca tattgctaat agcagctaca atccagctac cattctgctt      300

ttattttctg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa      360

tcttgttcat acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc      420

tggcccatca ctttggcaaa g                                                441


<210>  44
<211>  1438
<212>  DNA
<213>  artificial

<220>
<223>  FIX intron

<400>  44
ggtttgtttc cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct       60

gatgctgtct tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta      120

acagccagca cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc      180

atttttaaaa ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt      240

tcagttcatg atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa      300

aaattaaaag tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta      360

tttttgtttg gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc      420

ttatttacac aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt      480

aatgaggtgt gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa      540

cataaagatt aacctttcat tagcaagctg ttagttatca ccaacgcttt tcatggatta      600

ggaaaaaatc attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa      660

tactcagttg agttccctag gggagaaaag cacgcttaag aattgacata aagagtagga      720

agttagctaa tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt      780

tcccagagga aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac      840

aggaagcatt tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt      900

accaggatca ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc      960

cactccagac atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt     1020

tcttcaggag acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc     1080

agggtgatgg atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg     1140

tgaagttaac cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt     1200

agaaatctga ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt     1260

cctaaatctc catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct     1320

aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta     1380

aaattttcat gatgttttct tttttgctaa aactaaagaa ttattctttt acatttca       1438


<210>  45
<211>  1438
<212>  DNA
<213>  artificial

<220>
<223>  Modified FIX intron

<400>  45
ggtttgtttc cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct       60

gatgctgtct tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta      120

acagccagca cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc      180

atttttaaaa ctaaatagat cgacattgct tttgttgcat ttatgtttaa taaacactgt      240

tcagttcatg atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa      300

aaattaaaag tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta      360

tttttgtttg gacttaccac tttgaaatca aattgggaaa caaaagcaca aacaatggcc      420

ttatttacac aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt      480

aatgaggtgt gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa      540

cataaagatt aacctttcat tagcaagctg ttagttatca ccaacgcttt tcatggatta      600

ggaaaaaatc attttgtctc tttgtcaaac atcttggagt tgatatttgg ggaaacacaa      660

tactcagttg agttccctag gggagaaaag cacgcttaag aattgacata aagagtagga      720

agttagctat tgcaacatat atcactttgt tttttcacaa ctacagtgac tttttgtatt      780

tcccagagga aggcatacag ggaagaaatt atcccatttg gacaaacagc ttgttctcac      840

aggaagcatt tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt      900

accaggatca ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc      960

cactccagac atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt     1020

tcttcaggag acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc     1080

agggtgttgg atcactttgc aaagatcctc attgagctat tttcaagtgt tgacaaagtg     1140

tgaagttaac cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt     1200

agaaatctga ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt     1260

cctaaatctc catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct     1320

aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta     1380

aaattttctt gttgttttct tttttgctaa aactaaagaa ttattctttt acatttca       1438


<210>  46
<211>  881
<212>  DNA
<213>  artificial

<220>
<223>  Chicken beta-globin intron

<400>  46
gcgggagtcg ctgcgttgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc       60

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      120

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      180

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      240

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      300

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg      360

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt      420

gtgcgtgggg gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca      480

cccccctccc cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg      540

tggcgcgggg ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc      600

ggggccgcct cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg      660

cggctgtcga ggcgcggcga gccgcagcca ttgcctttta tggtaatcgt gcgagagggc      720

gcagggactt cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac      780

cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga      840

gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct c                          881


<210>  47
<211>  881
<212>  DNA
<213>  artificial

<220>
<223>  modified chicken-beta globin intron

<400>  47
gcgggagtcg ctgcgttgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc       60

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      120

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      180

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      240

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      300

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg      360

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt      420

gtgcgtgggg gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca      480

cccccctccc cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg      540

tggcgcgggg ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc      600

ggggccgcct cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg      660

cggctgtcga ggcgcggcga gccgcagcca ttgccttttt tggtaatcgt gcgagagggc      720

gcagggactt cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac      780

cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaat tgggcgggga      840

gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct c                          881


<210>  48
<211>  1518
<212>  PRT
<213>  artificial

<220>
<223>  D1a + D2,3 hGDE

<400>  48

Met Glu Lys Leu Glu Lys Thr Leu Phe Arg Leu Glu Gln Gly Tyr Glu 
1               5                   10                  15      


Leu Gln Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val 
            20                  25                  30          


Tyr Thr Asn Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe 
        35                  40                  45              


Arg Ser Leu Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp 
    50                  55                  60                  


Lys Tyr Cys Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr 
65                  70                  75                  80  


Phe Leu Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp 
                85                  90                  95      


Pro Ile Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys 
            100                 105                 110         


Val Thr Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu 
        115                 120                 125             


Trp Glu Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile 
    130                 135                 140                 


His Phe Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser 
145                 150                 155                 160 


Leu Ala Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg 
                165                 170                 175     


Lys Tyr Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys 
            180                 185                 190         


Glu Trp Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala 
        195                 200                 205             


Ala Asn Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu 
    210                 215                 220                 


Val Asn Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu 
225                 230                 235                 240 


Trp Arg Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly 
                245                 250                 255     


Ile Pro Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys 
            260                 265                 270         


Ile Ile Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe 
        275                 280                 285             


Gln Val Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr 
    290                 295                 300                 


Gln Glu Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr 
305                 310                 315                 320 


Ile Ile Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met 
                325                 330                 335     


Asn Ile Ala Leu Thr Thr Phe Ile Pro His Asp Lys Gly Pro Ala Ala 
            340                 345                 350         


Ile Glu Glu Cys Cys Asn Trp Phe His Lys Arg Met Glu Glu Leu Asn 
        355                 360                 365             


Ser Glu Lys His Arg Leu Ile Asn Tyr His Gln Glu Gln Ala Val Asn 
    370                 375                 380                 


Cys Leu Leu Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His Gly Pro 
385                 390                 395                 400 


Lys Leu Gly Pro Val Thr Arg Lys His Pro Leu Val Thr Arg Tyr Phe 
                405                 410                 415     


Thr Phe Pro Phe Glu Glu Ile Asp Phe Ser Met Glu Glu Ser Met Ile 
            420                 425                 430         


His Leu Pro Asn Lys Ala Cys Phe Leu Met Ala His Asn Gly Trp Val 
        435                 440                 445             


Met Gly Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu Val 
    450                 455                 460                 


Tyr Leu Arg Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg 
465                 470                 475                 480 


Tyr Gly Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys 
                485                 490                 495     


Lys Tyr Thr Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp 
            500                 505                 510         


Asn Cys His Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala 
        515                 520                 525             


Ala Arg Asn Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr 
    530                 535                 540                 


Gly Ser Glu Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly Ile Ser 
545                 550                 555                 560 


Ser Leu Ile Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu Glu Gly 
                565                 570                 575     


Arg Leu Val Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe Val Gln 
            580                 585                 590         


Pro Cys Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe Met 
        595                 600                 605             


Asp Ile Thr His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr 
    610                 615                 620                 


Asp Ala Leu Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys Ala Ser 
625                 630                 635                 640 


Gly Ser Thr Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile Ser Val 
                645                 650                 655     


Val Ser Glu Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu Ala Leu Pro 
            660                 665                 670         


Ser Asn Thr Gly Glu Val Asn Phe Gln Ser Gly Ile Ile Ala Ala Arg 
        675                 680                 685             


Cys Ala Ile Ser Lys Leu His Gln Glu Leu Gly Ala Lys Gly Phe Ile 
    690                 695                 700                 


Gln Val Tyr Val Asp Gln Val Asp Glu Asp Ile Val Ala Val Thr Arg 
705                 710                 715                 720 


His Ser Pro Ser Ile His Gln Ser Val Val Ala Val Thr Arg Thr Ala 
                725                 730                 735     


Phe Arg Asn Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val Pro Gln Met 
            740                 745                 750         


Cys Ile Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg Thr Ile 
        755                 760                 765             


Glu Arg Asn Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser Ile Asn Gly 
    770                 775                 780                 


Thr Pro Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu Asn Glu 
785                 790                 795                 800 


Ser Lys Ile Val Lys Gln Ala Gly Val Ala Thr Lys Gly Pro Asn Glu 
                805                 810                 815     


Tyr Ile Gln Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly Ser Val Ile 
            820                 825                 830         


Ile Phe Arg Val Ser Leu Asp Pro His Ala Gln Val Ala Val Gly Ile 
        835                 840                 845             


Leu Arg Asn His Leu Thr Gln Phe Ser Pro His Phe Lys Ser Gly Ser 
    850                 855                 860                 


Leu Ala Val Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro Phe Ala Ser 
865                 870                 875                 880 


Leu Ala Tyr Arg Leu Thr Leu Ala Glu Leu Asn Gln Ile Leu Tyr Arg 
                885                 890                 895     


Cys Glu Ser Glu Glu Lys Glu Asp Gly Gly Gly Cys Tyr Asp Ile Pro 
            900                 905                 910         


Asn Trp Ser Ala Leu Lys Tyr Ala Gly Leu Gln Gly Leu Met Ser Val 
        915                 920                 925             


Leu Ala Glu Ile Arg Pro Lys Asn Asp Leu Gly His Pro Phe Cys Asn 
    930                 935                 940                 


Asn Leu Arg Ser Gly Asp Trp Met Ile Asp Tyr Val Ser Asn Arg Leu 
945                 950                 955                 960 


Ile Ser Arg Ser Gly Thr Ile Ala Glu Val Gly Lys Trp Leu Gln Ala 
                965                 970                 975     


Met Phe Phe Tyr Leu Lys Gln Ile Pro Arg Tyr Leu Ile Pro Cys Tyr 
            980                 985                 990         


Phe Asp Ala Ile Leu Ile Gly Ala  Tyr Thr Thr Leu Leu  Asp Thr Ala 
        995                 1000                 1005             


Trp Lys  Gln Met Ser Ser Phe  Val Gln Asn Gly Ser  Thr Phe Val 
    1010                 1015                 1020             


Lys His  Leu Ser Leu Gly Ser  Val Gln Leu Cys Gly  Val Gly Lys 
    1025                 1030                 1035             


Phe Pro  Ser Leu Pro Ile Leu  Ser Pro Ala Leu Met  Asp Val Pro 
    1040                 1045                 1050             


Tyr Arg  Leu Asn Glu Ile Thr  Lys Glu Lys Glu Gln  Cys Cys Val 
    1055                 1060                 1065             


Ser Leu  Ala Ala Gly Leu Pro  His Phe Ser Ser Gly  Ile Phe Arg 
    1070                 1075                 1080             


Cys Trp  Gly Arg Asp Thr Phe  Ile Ala Leu Arg Gly  Ile Leu Leu 
    1085                 1090                 1095             


Ile Thr  Gly Arg Tyr Val Glu  Ala Arg Asn Ile Ile  Leu Ala Phe 
    1100                 1105                 1110             


Ala Gly  Thr Leu Arg His Gly  Leu Ile Pro Asn Leu  Leu Gly Glu 
    1115                 1120                 1125             


Gly Ile  Tyr Ala Arg Tyr Asn  Cys Arg Asp Ala Val  Trp Trp Trp 
    1130                 1135                 1140             


Leu Gln  Cys Ile Gln Asp Tyr  Cys Lys Met Val Pro  Asn Gly Leu 
    1145                 1150                 1155             


Asp Ile  Leu Lys Cys Pro Val  Ser Arg Met Tyr Pro  Thr Asp Asp 
    1160                 1165                 1170             


Ser Ala  Pro Leu Pro Ala Gly  Thr Leu Asp Gln Pro  Leu Phe Glu 
    1175                 1180                 1185             


Val Ile  Gln Glu Ala Met Gln  Lys His Met Gln Gly  Ile Gln Phe 
    1190                 1195                 1200             


Arg Glu  Arg Asn Ala Gly Pro  Gln Ile Asp Arg Asn  Met Lys Asp 
    1205                 1210                 1215             


Glu Gly  Phe Asn Ile Thr Ala  Gly Val Asp Glu Glu  Thr Gly Phe 
    1220                 1225                 1230             


Val Tyr  Gly Gly Asn Arg Phe  Asn Cys Gly Thr Trp  Met Asp Lys 
    1235                 1240                 1245             


Met Gly  Glu Ser Asp Arg Ala  Arg Asn Arg Gly Ile  Pro Ala Thr 
    1250                 1255                 1260             


Pro Arg  Asp Gly Ser Ala Val  Glu Ile Val Gly Leu  Ser Lys Ser 
    1265                 1270                 1275             


Ala Val  Arg Trp Leu Leu Glu  Leu Ser Lys Lys Asn  Ile Phe Pro 
    1280                 1285                 1290             


Tyr His  Glu Val Thr Val Lys  Arg His Gly Lys Ala  Ile Lys Val 
    1295                 1300                 1305             


Ser Tyr  Asp Glu Trp Asn Arg  Lys Ile Gln Asp Asn  Phe Glu Lys 
    1310                 1315                 1320             


Leu Phe  His Val Ser Glu Asp  Pro Ser Asp Leu Asn  Glu Lys His 
    1325                 1330                 1335             


Pro Asn  Leu Val His Lys Arg  Gly Ile Tyr Lys Asp  Ser Tyr Gly 
    1340                 1345                 1350             


Ala Ser  Ser Pro Trp Cys Asp  Tyr Gln Leu Arg Pro  Asn Phe Thr 
    1355                 1360                 1365             


Ile Ala  Met Val Val Ala Pro  Glu Leu Phe Thr Thr  Glu Lys Ala 
    1370                 1375                 1380             


Trp Lys  Ala Leu Glu Ile Ala  Glu Lys Lys Leu Leu  Gly Pro Leu 
    1385                 1390                 1395             


Gly Met  Lys Thr Leu Asp Pro  Asp Asp Met Val Tyr  Cys Gly Ile 
    1400                 1405                 1410             


Tyr Asp  Asn Ala Leu Asp Asn  Asp Asn Tyr Asn Leu  Ala Lys Gly 
    1415                 1420                 1425             


Phe Asn  Tyr His Gln Gly Pro  Glu Trp Leu Trp Pro  Ile Gly Tyr 
    1430                 1435                 1440             


Phe Leu  Arg Ala Lys Leu Tyr  Phe Ser Arg Leu Met  Gly Pro Glu 
    1445                 1450                 1455             


Thr Thr  Ala Lys Thr Ile Val  Leu Val Lys Asn Val  Leu Ser Arg 
    1460                 1465                 1470             


His Tyr  Val His Leu Glu Arg  Ser Pro Trp Lys Gly  Leu Pro Glu 
    1475                 1480                 1485             


Leu Thr  Asn Glu Asn Ala Gln  Tyr Cys Pro Phe Ser  Cys Glu Thr 
    1490                 1495                 1500             


Gln Ala  Trp Ser Ile Ala Thr  Ile Leu Glu Thr Leu  Tyr Asp Leu 
    1505                 1510                 1515             


<210>  49
<211>  1503
<212>  PRT
<213>  artificial

<220>
<223>  D1b1 + D2,3 hGDE

<400>  49

Met Leu Gln Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr 
1               5                   10                  15      


Val Tyr Thr Asn Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys 
            20                  25                  30          


Phe Arg Ser Leu Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser 
        35                  40                  45              


Asp Lys Tyr Cys Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr 
    50                  55                  60                  


Tyr Phe Leu Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val 
65                  70                  75                  80  


Asp Pro Ile Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp 
                85                  90                  95      


Cys Val Thr Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp 
            100                 105                 110         


Glu Trp Glu Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met 
        115                 120                 125             


Ile His Phe Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr 
    130                 135                 140                 


Ser Leu Ala Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn 
145                 150                 155                 160 


Arg Lys Tyr Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys 
                165                 170                 175     


Lys Glu Trp Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr 
            180                 185                 190         


Ala Ala Asn Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn 
        195                 200                 205             


Leu Val Asn Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala 
    210                 215                 220                 


Leu Trp Arg Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys 
225                 230                 235                 240 


Gly Ile Pro Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg 
                245                 250                 255     


Lys Ile Ile Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe 
            260                 265                 270         


Phe Gln Val Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu 
        275                 280                 285             


Thr Gln Glu Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu 
    290                 295                 300                 


Thr Ile Ile Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp 
305                 310                 315                 320 


Met Asn Ile Ala Leu Thr Thr Phe Ile Pro His Asp Lys Gly Pro Ala 
                325                 330                 335     


Ala Ile Glu Glu Cys Cys Asn Trp Phe His Lys Arg Met Glu Glu Leu 
            340                 345                 350         


Asn Ser Glu Lys His Arg Leu Ile Asn Tyr His Gln Glu Gln Ala Val 
        355                 360                 365             


Asn Cys Leu Leu Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His Gly 
    370                 375                 380                 


Pro Lys Leu Gly Pro Val Thr Arg Lys His Pro Leu Val Thr Arg Tyr 
385                 390                 395                 400 


Phe Thr Phe Pro Phe Glu Glu Ile Asp Phe Ser Met Glu Glu Ser Met 
                405                 410                 415     


Ile His Leu Pro Asn Lys Ala Cys Phe Leu Met Ala His Asn Gly Trp 
            420                 425                 430         


Val Met Gly Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu 
        435                 440                 445             


Val Tyr Leu Arg Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys Leu 
    450                 455                 460                 


Arg Tyr Gly Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met 
465                 470                 475                 480 


Lys Lys Tyr Thr Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu 
                485                 490                 495     


Asp Asn Cys His Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp 
            500                 505                 510         


Ala Ala Arg Asn Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe 
        515                 520                 525             


Thr Gly Ser Glu Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly Ile 
    530                 535                 540                 


Ser Ser Leu Ile Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu Glu 
545                 550                 555                 560 


Gly Arg Leu Val Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe Val 
                565                 570                 575     


Gln Pro Cys Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe 
            580                 585                 590         


Met Asp Ile Thr His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala 
        595                 600                 605             


Tyr Asp Ala Leu Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys Ala 
    610                 615                 620                 


Ser Gly Ser Thr Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile Ser 
625                 630                 635                 640 


Val Val Ser Glu Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu Ala Leu 
                645                 650                 655     


Pro Ser Asn Thr Gly Glu Val Asn Phe Gln Ser Gly Ile Ile Ala Ala 
            660                 665                 670         


Arg Cys Ala Ile Ser Lys Leu His Gln Glu Leu Gly Ala Lys Gly Phe 
        675                 680                 685             


Ile Gln Val Tyr Val Asp Gln Val Asp Glu Asp Ile Val Ala Val Thr 
    690                 695                 700                 


Arg His Ser Pro Ser Ile His Gln Ser Val Val Ala Val Thr Arg Thr 
705                 710                 715                 720 


Ala Phe Arg Asn Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val Pro Gln 
                725                 730                 735     


Met Cys Ile Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg Thr 
            740                 745                 750         


Ile Glu Arg Asn Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser Ile Asn 
        755                 760                 765             


Gly Thr Pro Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu Asn 
    770                 775                 780                 


Glu Ser Lys Ile Val Lys Gln Ala Gly Val Ala Thr Lys Gly Pro Asn 
785                 790                 795                 800 


Glu Tyr Ile Gln Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly Ser Val 
                805                 810                 815     


Ile Ile Phe Arg Val Ser Leu Asp Pro His Ala Gln Val Ala Val Gly 
            820                 825                 830         


Ile Leu Arg Asn His Leu Thr Gln Phe Ser Pro His Phe Lys Ser Gly 
        835                 840                 845             


Ser Leu Ala Val Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro Phe Ala 
    850                 855                 860                 


Ser Leu Ala Tyr Arg Leu Thr Leu Ala Glu Leu Asn Gln Ile Leu Tyr 
865                 870                 875                 880 


Arg Cys Glu Ser Glu Glu Lys Glu Asp Gly Gly Gly Cys Tyr Asp Ile 
                885                 890                 895     


Pro Asn Trp Ser Ala Leu Lys Tyr Ala Gly Leu Gln Gly Leu Met Ser 
            900                 905                 910         


Val Leu Ala Glu Ile Arg Pro Lys Asn Asp Leu Gly His Pro Phe Cys 
        915                 920                 925             


Asn Asn Leu Arg Ser Gly Asp Trp Met Ile Asp Tyr Val Ser Asn Arg 
    930                 935                 940                 


Leu Ile Ser Arg Ser Gly Thr Ile Ala Glu Val Gly Lys Trp Leu Gln 
945                 950                 955                 960 


Ala Met Phe Phe Tyr Leu Lys Gln Ile Pro Arg Tyr Leu Ile Pro Cys 
                965                 970                 975     


Tyr Phe Asp Ala Ile Leu Ile Gly Ala Tyr Thr Thr Leu Leu Asp Thr 
            980                 985                 990         


Ala Trp Lys Gln Met Ser Ser Phe  Val Gln Asn Gly Ser  Thr Phe Val 
        995                 1000                 1005             


Lys His  Leu Ser Leu Gly Ser  Val Gln Leu Cys Gly  Val Gly Lys 
    1010                 1015                 1020             


Phe Pro  Ser Leu Pro Ile Leu  Ser Pro Ala Leu Met  Asp Val Pro 
    1025                 1030                 1035             


Tyr Arg  Leu Asn Glu Ile Thr  Lys Glu Lys Glu Gln  Cys Cys Val 
    1040                 1045                 1050             


Ser Leu  Ala Ala Gly Leu Pro  His Phe Ser Ser Gly  Ile Phe Arg 
    1055                 1060                 1065             


Cys Trp  Gly Arg Asp Thr Phe  Ile Ala Leu Arg Gly  Ile Leu Leu 
    1070                 1075                 1080             


Ile Thr  Gly Arg Tyr Val Glu  Ala Arg Asn Ile Ile  Leu Ala Phe 
    1085                 1090                 1095             


Ala Gly  Thr Leu Arg His Gly  Leu Ile Pro Asn Leu  Leu Gly Glu 
    1100                 1105                 1110             


Gly Ile  Tyr Ala Arg Tyr Asn  Cys Arg Asp Ala Val  Trp Trp Trp 
    1115                 1120                 1125             


Leu Gln  Cys Ile Gln Asp Tyr  Cys Lys Met Val Pro  Asn Gly Leu 
    1130                 1135                 1140             


Asp Ile  Leu Lys Cys Pro Val  Ser Arg Met Tyr Pro  Thr Asp Asp 
    1145                 1150                 1155             


Ser Ala  Pro Leu Pro Ala Gly  Thr Leu Asp Gln Pro  Leu Phe Glu 
    1160                 1165                 1170             


Val Ile  Gln Glu Ala Met Gln  Lys His Met Gln Gly  Ile Gln Phe 
    1175                 1180                 1185             


Arg Glu  Arg Asn Ala Gly Pro  Gln Ile Asp Arg Asn  Met Lys Asp 
    1190                 1195                 1200             


Glu Gly  Phe Asn Ile Thr Ala  Gly Val Asp Glu Glu  Thr Gly Phe 
    1205                 1210                 1215             


Val Tyr  Gly Gly Asn Arg Phe  Asn Cys Gly Thr Trp  Met Asp Lys 
    1220                 1225                 1230             


Met Gly  Glu Ser Asp Arg Ala  Arg Asn Arg Gly Ile  Pro Ala Thr 
    1235                 1240                 1245             


Pro Arg  Asp Gly Ser Ala Val  Glu Ile Val Gly Leu  Ser Lys Ser 
    1250                 1255                 1260             


Ala Val  Arg Trp Leu Leu Glu  Leu Ser Lys Lys Asn  Ile Phe Pro 
    1265                 1270                 1275             


Tyr His  Glu Val Thr Val Lys  Arg His Gly Lys Ala  Ile Lys Val 
    1280                 1285                 1290             


Ser Tyr  Asp Glu Trp Asn Arg  Lys Ile Gln Asp Asn  Phe Glu Lys 
    1295                 1300                 1305             


Leu Phe  His Val Ser Glu Asp  Pro Ser Asp Leu Asn  Glu Lys His 
    1310                 1315                 1320             


Pro Asn  Leu Val His Lys Arg  Gly Ile Tyr Lys Asp  Ser Tyr Gly 
    1325                 1330                 1335             


Ala Ser  Ser Pro Trp Cys Asp  Tyr Gln Leu Arg Pro  Asn Phe Thr 
    1340                 1345                 1350             


Ile Ala  Met Val Val Ala Pro  Glu Leu Phe Thr Thr  Glu Lys Ala 
    1355                 1360                 1365             


Trp Lys  Ala Leu Glu Ile Ala  Glu Lys Lys Leu Leu  Gly Pro Leu 
    1370                 1375                 1380             


Gly Met  Lys Thr Leu Asp Pro  Asp Asp Met Val Tyr  Cys Gly Ile 
    1385                 1390                 1395             


Tyr Asp  Asn Ala Leu Asp Asn  Asp Asn Tyr Asn Leu  Ala Lys Gly 
    1400                 1405                 1410             


Phe Asn  Tyr His Gln Gly Pro  Glu Trp Leu Trp Pro  Ile Gly Tyr 
    1415                 1420                 1425             


Phe Leu  Arg Ala Lys Leu Tyr  Phe Ser Arg Leu Met  Gly Pro Glu 
    1430                 1435                 1440             


Thr Thr  Ala Lys Thr Ile Val  Leu Val Lys Asn Val  Leu Ser Arg 
    1445                 1450                 1455             


His Tyr  Val His Leu Glu Arg  Ser Pro Trp Lys Gly  Leu Pro Glu 
    1460                 1465                 1470             


Leu Thr  Asn Glu Asn Ala Gln  Tyr Cys Pro Phe Ser  Cys Glu Thr 
    1475                 1480                 1485             


Gln Ala  Trp Ser Ile Ala Thr  Ile Leu Glu Thr Leu  Tyr Asp Leu 
    1490                 1495                 1500             


<210>  50
<211>  1452
<212>  PRT
<213>  artificial

<220>
<223>  D1b2 + D2,3 hGDE

<400>  50

Met Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu 
1               5                   10                  15      


Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile 
            20                  25                  30          


Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr 
        35                  40                  45              


Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu 
    50                  55                  60                  


Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe 
65                  70                  75                  80  


Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala 
                85                  90                  95      


Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr 
            100                 105                 110         


Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp 
        115                 120                 125             


Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn 
    130                 135                 140                 


Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn 
145                 150                 155                 160 


Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg 
                165                 170                 175     


Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro 
            180                 185                 190         


Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile 
        195                 200                 205             


Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val 
    210                 215                 220                 


Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu 
225                 230                 235                 240 


Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile 
                245                 250                 255     


Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile 
            260                 265                 270         


Ala Leu Thr Thr Phe Ile Pro His Asp Lys Gly Pro Ala Ala Ile Glu 
        275                 280                 285             


Glu Cys Cys Asn Trp Phe His Lys Arg Met Glu Glu Leu Asn Ser Glu 
    290                 295                 300                 


Lys His Arg Leu Ile Asn Tyr His Gln Glu Gln Ala Val Asn Cys Leu 
305                 310                 315                 320 


Leu Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His Gly Pro Lys Leu 
                325                 330                 335     


Gly Pro Val Thr Arg Lys His Pro Leu Val Thr Arg Tyr Phe Thr Phe 
            340                 345                 350         


Pro Phe Glu Glu Ile Asp Phe Ser Met Glu Glu Ser Met Ile His Leu 
        355                 360                 365             


Pro Asn Lys Ala Cys Phe Leu Met Ala His Asn Gly Trp Val Met Gly 
    370                 375                 380                 


Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu 
385                 390                 395                 400 


Arg Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly 
                405                 410                 415     


Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr 
            420                 425                 430         


Thr Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys 
        435                 440                 445             


His Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg 
    450                 455                 460                 


Asn Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser 
465                 470                 475                 480 


Glu Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu 
                485                 490                 495     


Ile Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu 
            500                 505                 510         


Val Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys 
        515                 520                 525             


Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile 
    530                 535                 540                 


Thr His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala 
545                 550                 555                 560 


Leu Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser 
                565                 570                 575     


Thr Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile Ser Val Val Ser 
            580                 585                 590         


Glu Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu Ala Leu Pro Ser Asn 
        595                 600                 605             


Thr Gly Glu Val Asn Phe Gln Ser Gly Ile Ile Ala Ala Arg Cys Ala 
    610                 615                 620                 


Ile Ser Lys Leu His Gln Glu Leu Gly Ala Lys Gly Phe Ile Gln Val 
625                 630                 635                 640 


Tyr Val Asp Gln Val Asp Glu Asp Ile Val Ala Val Thr Arg His Ser 
                645                 650                 655     


Pro Ser Ile His Gln Ser Val Val Ala Val Thr Arg Thr Ala Phe Arg 
            660                 665                 670         


Asn Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val Pro Gln Met Cys Ile 
        675                 680                 685             


Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg Thr Ile Glu Arg 
    690                 695                 700                 


Asn Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro 
705                 710                 715                 720 


Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu Asn Glu Ser Lys 
                725                 730                 735     


Ile Val Lys Gln Ala Gly Val Ala Thr Lys Gly Pro Asn Glu Tyr Ile 
            740                 745                 750         


Gln Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly Ser Val Ile Ile Phe 
        755                 760                 765             


Arg Val Ser Leu Asp Pro His Ala Gln Val Ala Val Gly Ile Leu Arg 
    770                 775                 780                 


Asn His Leu Thr Gln Phe Ser Pro His Phe Lys Ser Gly Ser Leu Ala 
785                 790                 795                 800 


Val Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro Phe Ala Ser Leu Ala 
                805                 810                 815     


Tyr Arg Leu Thr Leu Ala Glu Leu Asn Gln Ile Leu Tyr Arg Cys Glu 
            820                 825                 830         


Ser Glu Glu Lys Glu Asp Gly Gly Gly Cys Tyr Asp Ile Pro Asn Trp 
        835                 840                 845             


Ser Ala Leu Lys Tyr Ala Gly Leu Gln Gly Leu Met Ser Val Leu Ala 
    850                 855                 860                 


Glu Ile Arg Pro Lys Asn Asp Leu Gly His Pro Phe Cys Asn Asn Leu 
865                 870                 875                 880 


Arg Ser Gly Asp Trp Met Ile Asp Tyr Val Ser Asn Arg Leu Ile Ser 
                885                 890                 895     


Arg Ser Gly Thr Ile Ala Glu Val Gly Lys Trp Leu Gln Ala Met Phe 
            900                 905                 910         


Phe Tyr Leu Lys Gln Ile Pro Arg Tyr Leu Ile Pro Cys Tyr Phe Asp 
        915                 920                 925             


Ala Ile Leu Ile Gly Ala Tyr Thr Thr Leu Leu Asp Thr Ala Trp Lys 
    930                 935                 940                 


Gln Met Ser Ser Phe Val Gln Asn Gly Ser Thr Phe Val Lys His Leu 
945                 950                 955                 960 


Ser Leu Gly Ser Val Gln Leu Cys Gly Val Gly Lys Phe Pro Ser Leu 
                965                 970                 975     


Pro Ile Leu Ser Pro Ala Leu Met Asp Val Pro Tyr Arg Leu Asn Glu 
            980                 985                 990         


Ile Thr Lys Glu Lys Glu Gln Cys  Cys Val Ser Leu Ala  Ala Gly Leu 
        995                 1000                 1005             


Pro His  Phe Ser Ser Gly Ile  Phe Arg Cys Trp Gly  Arg Asp Thr 
    1010                 1015                 1020             


Phe Ile  Ala Leu Arg Gly Ile  Leu Leu Ile Thr Gly  Arg Tyr Val 
    1025                 1030                 1035             


Glu Ala  Arg Asn Ile Ile Leu  Ala Phe Ala Gly Thr  Leu Arg His 
    1040                 1045                 1050             


Gly Leu  Ile Pro Asn Leu Leu  Gly Glu Gly Ile Tyr  Ala Arg Tyr 
    1055                 1060                 1065             


Asn Cys  Arg Asp Ala Val Trp  Trp Trp Leu Gln Cys  Ile Gln Asp 
    1070                 1075                 1080             


Tyr Cys  Lys Met Val Pro Asn  Gly Leu Asp Ile Leu  Lys Cys Pro 
    1085                 1090                 1095             


Val Ser  Arg Met Tyr Pro Thr  Asp Asp Ser Ala Pro  Leu Pro Ala 
    1100                 1105                 1110             


Gly Thr  Leu Asp Gln Pro Leu  Phe Glu Val Ile Gln  Glu Ala Met 
    1115                 1120                 1125             


Gln Lys  His Met Gln Gly Ile  Gln Phe Arg Glu Arg  Asn Ala Gly 
    1130                 1135                 1140             


Pro Gln  Ile Asp Arg Asn Met  Lys Asp Glu Gly Phe  Asn Ile Thr 
    1145                 1150                 1155             


Ala Gly  Val Asp Glu Glu Thr  Gly Phe Val Tyr Gly  Gly Asn Arg 
    1160                 1165                 1170             


Phe Asn  Cys Gly Thr Trp Met  Asp Lys Met Gly Glu  Ser Asp Arg 
    1175                 1180                 1185             


Ala Arg  Asn Arg Gly Ile Pro  Ala Thr Pro Arg Asp  Gly Ser Ala 
    1190                 1195                 1200             


Val Glu  Ile Val Gly Leu Ser  Lys Ser Ala Val Arg  Trp Leu Leu 
    1205                 1210                 1215             


Glu Leu  Ser Lys Lys Asn Ile  Phe Pro Tyr His Glu  Val Thr Val 
    1220                 1225                 1230             


Lys Arg  His Gly Lys Ala Ile  Lys Val Ser Tyr Asp  Glu Trp Asn 
    1235                 1240                 1245             


Arg Lys  Ile Gln Asp Asn Phe  Glu Lys Leu Phe His  Val Ser Glu 
    1250                 1255                 1260             


Asp Pro  Ser Asp Leu Asn Glu  Lys His Pro Asn Leu  Val His Lys 
    1265                 1270                 1275             


Arg Gly  Ile Tyr Lys Asp Ser  Tyr Gly Ala Ser Ser  Pro Trp Cys 
    1280                 1285                 1290             


Asp Tyr  Gln Leu Arg Pro Asn  Phe Thr Ile Ala Met  Val Val Ala 
    1295                 1300                 1305             


Pro Glu  Leu Phe Thr Thr Glu  Lys Ala Trp Lys Ala  Leu Glu Ile 
    1310                 1315                 1320             


Ala Glu  Lys Lys Leu Leu Gly  Pro Leu Gly Met Lys  Thr Leu Asp 
    1325                 1330                 1335             


Pro Asp  Asp Met Val Tyr Cys  Gly Ile Tyr Asp Asn  Ala Leu Asp 
    1340                 1345                 1350             


Asn Asp  Asn Tyr Asn Leu Ala  Lys Gly Phe Asn Tyr  His Gln Gly 
    1355                 1360                 1365             


Pro Glu  Trp Leu Trp Pro Ile  Gly Tyr Phe Leu Arg  Ala Lys Leu 
    1370                 1375                 1380             


Tyr Phe  Ser Arg Leu Met Gly  Pro Glu Thr Thr Ala  Lys Thr Ile 
    1385                 1390                 1395             


Val Leu  Val Lys Asn Val Leu  Ser Arg His Tyr Val  His Leu Glu 
    1400                 1405                 1410             


Arg Ser  Pro Trp Lys Gly Leu  Pro Glu Leu Thr Asn  Glu Asn Ala 
    1415                 1420                 1425             


Gln Tyr  Cys Pro Phe Ser Cys  Glu Thr Gln Ala Trp  Ser Ile Ala 
    1430                 1435                 1440             


Thr Ile  Leu Glu Thr Leu Tyr  Asp Leu 
    1445                 1450         


<210>  51
<211>  1430
<212>  PRT
<213>  artificial

<220>
<223>  D1b3 + D2,3 hGDE

<400>  51

Met Gly Gly Tyr Ile Val Val Asp Pro Ile Leu Arg Val Gly Ala Asp 
1               5                   10                  15      


Asn His Val Leu Pro Leu Asp Cys Val Thr Leu Gln Thr Phe Leu Ala 
            20                  25                  30          


Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu Ser Arg Leu Arg Val Ala 
        35                  40                  45              


Lys Glu Ser Gly Tyr Asn Met Ile His Phe Thr Pro Leu Gln Thr Leu 
    50                  55                  60                  


Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala Asn Gln Leu Glu Leu Asn 
65                  70                  75                  80  


Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr Thr Trp Asn Asp Val Gly 
                85                  90                  95      


Gln Leu Val Glu Lys Leu Lys Lys Glu Trp Asn Val Ile Cys Ile Thr 
            100                 105                 110         


Asp Val Val Tyr Asn His Thr Ala Ala Asn Ser Lys Trp Ile Gln Glu 
        115                 120                 125             


His Pro Glu Cys Ala Tyr Asn Leu Val Asn Ser Pro His Leu Lys Pro 
    130                 135                 140                 


Ala Trp Val Leu Asp Arg Ala Leu Trp Arg Phe Ser Cys Asp Val Ala 
145                 150                 155                 160 


Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro Ala Leu Ile Glu Asn Asp 
                165                 170                 175     


His His Met Asn Ser Ile Arg Lys Ile Ile Trp Glu Asp Ile Phe Pro 
            180                 185                 190         


Lys Leu Lys Leu Trp Glu Phe Phe Gln Val Asp Val Asn Lys Ala Val 
        195                 200                 205             


Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu Asn Arg Arg Val Thr Lys 
    210                 215                 220                 


Ser Asp Pro Asn Gln His Leu Thr Ile Ile Gln Asp Pro Glu Tyr Arg 
225                 230                 235                 240 


Arg Phe Gly Cys Thr Val Asp Met Asn Ile Ala Leu Thr Thr Phe Ile 
                245                 250                 255     


Pro His Asp Lys Gly Pro Ala Ala Ile Glu Glu Cys Cys Asn Trp Phe 
            260                 265                 270         


His Lys Arg Met Glu Glu Leu Asn Ser Glu Lys His Arg Leu Ile Asn 
        275                 280                 285             


Tyr His Gln Glu Gln Ala Val Asn Cys Leu Leu Gly Asn Val Phe Tyr 
    290                 295                 300                 


Glu Arg Leu Ala Gly His Gly Pro Lys Leu Gly Pro Val Thr Arg Lys 
305                 310                 315                 320 


His Pro Leu Val Thr Arg Tyr Phe Thr Phe Pro Phe Glu Glu Ile Asp 
                325                 330                 335     


Phe Ser Met Glu Glu Ser Met Ile His Leu Pro Asn Lys Ala Cys Phe 
            340                 345                 350         


Leu Met Ala His Asn Gly Trp Val Met Gly Asp Asp Pro Leu Arg Asn 
        355                 360                 365             


Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu Arg Arg Glu Leu Ile Cys 
    370                 375                 380                 


Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly Asn Lys Pro Glu Asp Cys 
385                 390                 395                 400 


Pro Tyr Leu Trp Ala His Met Lys Lys Tyr Thr Glu Ile Thr Ala Thr 
                405                 410                 415     


Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys His Ser Thr Pro Leu His 
            420                 425                 430         


Val Ala Glu Tyr Met Leu Asp Ala Ala Arg Asn Leu Gln Pro Asn Leu 
        435                 440                 445             


Tyr Val Val Ala Glu Leu Phe Thr Gly Ser Glu Asp Leu Asp Asn Val 
    450                 455                 460                 


Phe Val Thr Arg Leu Gly Ile Ser Ser Leu Ile Arg Glu Ala Met Ser 
465                 470                 475                 480 


Ala Tyr Asn Ser His Glu Glu Gly Arg Leu Val Tyr Arg Tyr Gly Gly 
                485                 490                 495     


Glu Pro Val Gly Ser Phe Val Gln Pro Cys Leu Arg Pro Leu Met Pro 
            500                 505                 510         


Ala Ile Ala His Ala Leu Phe Met Asp Ile Thr His Asp Asn Glu Cys 
        515                 520                 525             


Pro Ile Val His Arg Ser Ala Tyr Asp Ala Leu Pro Ser Thr Thr Ile 
    530                 535                 540                 


Val Ser Met Ala Cys Cys Ala Ser Gly Ser Thr Arg Gly Tyr Asp Glu 
545                 550                 555                 560 


Leu Val Pro His Gln Ile Ser Val Val Ser Glu Glu Arg Phe Tyr Thr 
                565                 570                 575     


Lys Trp Asn Pro Glu Ala Leu Pro Ser Asn Thr Gly Glu Val Asn Phe 
            580                 585                 590         


Gln Ser Gly Ile Ile Ala Ala Arg Cys Ala Ile Ser Lys Leu His Gln 
        595                 600                 605             


Glu Leu Gly Ala Lys Gly Phe Ile Gln Val Tyr Val Asp Gln Val Asp 
    610                 615                 620                 


Glu Asp Ile Val Ala Val Thr Arg His Ser Pro Ser Ile His Gln Ser 
625                 630                 635                 640 


Val Val Ala Val Thr Arg Thr Ala Phe Arg Asn Pro Lys Thr Ser Phe 
                645                 650                 655     


Tyr Ser Lys Glu Val Pro Gln Met Cys Ile Pro Gly Lys Ile Glu Glu 
            660                 665                 670         


Val Val Leu Glu Ala Arg Thr Ile Glu Arg Asn Thr Lys Pro Tyr Arg 
        675                 680                 685             


Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro Asp Ile Thr Val Glu Ile 
    690                 695                 700                 


Arg Glu His Ile Gln Leu Asn Glu Ser Lys Ile Val Lys Gln Ala Gly 
705                 710                 715                 720 


Val Ala Thr Lys Gly Pro Asn Glu Tyr Ile Gln Glu Ile Glu Phe Glu 
                725                 730                 735     


Asn Leu Ser Pro Gly Ser Val Ile Ile Phe Arg Val Ser Leu Asp Pro 
            740                 745                 750         


His Ala Gln Val Ala Val Gly Ile Leu Arg Asn His Leu Thr Gln Phe 
        755                 760                 765             


Ser Pro His Phe Lys Ser Gly Ser Leu Ala Val Asp Asn Ala Asp Pro 
    770                 775                 780                 


Ile Leu Lys Ile Pro Phe Ala Ser Leu Ala Tyr Arg Leu Thr Leu Ala 
785                 790                 795                 800 


Glu Leu Asn Gln Ile Leu Tyr Arg Cys Glu Ser Glu Glu Lys Glu Asp 
                805                 810                 815     


Gly Gly Gly Cys Tyr Asp Ile Pro Asn Trp Ser Ala Leu Lys Tyr Ala 
            820                 825                 830         


Gly Leu Gln Gly Leu Met Ser Val Leu Ala Glu Ile Arg Pro Lys Asn 
        835                 840                 845             


Asp Leu Gly His Pro Phe Cys Asn Asn Leu Arg Ser Gly Asp Trp Met 
    850                 855                 860                 


Ile Asp Tyr Val Ser Asn Arg Leu Ile Ser Arg Ser Gly Thr Ile Ala 
865                 870                 875                 880 


Glu Val Gly Lys Trp Leu Gln Ala Met Phe Phe Tyr Leu Lys Gln Ile 
                885                 890                 895     


Pro Arg Tyr Leu Ile Pro Cys Tyr Phe Asp Ala Ile Leu Ile Gly Ala 
            900                 905                 910         


Tyr Thr Thr Leu Leu Asp Thr Ala Trp Lys Gln Met Ser Ser Phe Val 
        915                 920                 925             


Gln Asn Gly Ser Thr Phe Val Lys His Leu Ser Leu Gly Ser Val Gln 
    930                 935                 940                 


Leu Cys Gly Val Gly Lys Phe Pro Ser Leu Pro Ile Leu Ser Pro Ala 
945                 950                 955                 960 


Leu Met Asp Val Pro Tyr Arg Leu Asn Glu Ile Thr Lys Glu Lys Glu 
                965                 970                 975     


Gln Cys Cys Val Ser Leu Ala Ala Gly Leu Pro His Phe Ser Ser Gly 
            980                 985                 990         


Ile Phe Arg Cys Trp Gly Arg Asp  Thr Phe Ile Ala Leu  Arg Gly Ile 
        995                 1000                 1005             


Leu Leu  Ile Thr Gly Arg Tyr  Val Glu Ala Arg Asn  Ile Ile Leu 
    1010                 1015                 1020             


Ala Phe  Ala Gly Thr Leu Arg  His Gly Leu Ile Pro  Asn Leu Leu 
    1025                 1030                 1035             


Gly Glu  Gly Ile Tyr Ala Arg  Tyr Asn Cys Arg Asp  Ala Val Trp 
    1040                 1045                 1050             


Trp Trp  Leu Gln Cys Ile Gln  Asp Tyr Cys Lys Met  Val Pro Asn 
    1055                 1060                 1065             


Gly Leu  Asp Ile Leu Lys Cys  Pro Val Ser Arg Met  Tyr Pro Thr 
    1070                 1075                 1080             


Asp Asp  Ser Ala Pro Leu Pro  Ala Gly Thr Leu Asp  Gln Pro Leu 
    1085                 1090                 1095             


Phe Glu  Val Ile Gln Glu Ala  Met Gln Lys His Met  Gln Gly Ile 
    1100                 1105                 1110             


Gln Phe  Arg Glu Arg Asn Ala  Gly Pro Gln Ile Asp  Arg Asn Met 
    1115                 1120                 1125             


Lys Asp  Glu Gly Phe Asn Ile  Thr Ala Gly Val Asp  Glu Glu Thr 
    1130                 1135                 1140             


Gly Phe  Val Tyr Gly Gly Asn  Arg Phe Asn Cys Gly  Thr Trp Met 
    1145                 1150                 1155             


Asp Lys  Met Gly Glu Ser Asp  Arg Ala Arg Asn Arg  Gly Ile Pro 
    1160                 1165                 1170             


Ala Thr  Pro Arg Asp Gly Ser  Ala Val Glu Ile Val  Gly Leu Ser 
    1175                 1180                 1185             


Lys Ser  Ala Val Arg Trp Leu  Leu Glu Leu Ser Lys  Lys Asn Ile 
    1190                 1195                 1200             


Phe Pro  Tyr His Glu Val Thr  Val Lys Arg His Gly  Lys Ala Ile 
    1205                 1210                 1215             


Lys Val  Ser Tyr Asp Glu Trp  Asn Arg Lys Ile Gln  Asp Asn Phe 
    1220                 1225                 1230             


Glu Lys  Leu Phe His Val Ser  Glu Asp Pro Ser Asp  Leu Asn Glu 
    1235                 1240                 1245             


Lys His  Pro Asn Leu Val His  Lys Arg Gly Ile Tyr  Lys Asp Ser 
    1250                 1255                 1260             


Tyr Gly  Ala Ser Ser Pro Trp  Cys Asp Tyr Gln Leu  Arg Pro Asn 
    1265                 1270                 1275             


Phe Thr  Ile Ala Met Val Val  Ala Pro Glu Leu Phe  Thr Thr Glu 
    1280                 1285                 1290             


Lys Ala  Trp Lys Ala Leu Glu  Ile Ala Glu Lys Lys  Leu Leu Gly 
    1295                 1300                 1305             


Pro Leu  Gly Met Lys Thr Leu  Asp Pro Asp Asp Met  Val Tyr Cys 
    1310                 1315                 1320             


Gly Ile  Tyr Asp Asn Ala Leu  Asp Asn Asp Asn Tyr  Asn Leu Ala 
    1325                 1330                 1335             


Lys Gly  Phe Asn Tyr His Gln  Gly Pro Glu Trp Leu  Trp Pro Ile 
    1340                 1345                 1350             


Gly Tyr  Phe Leu Arg Ala Lys  Leu Tyr Phe Ser Arg  Leu Met Gly 
    1355                 1360                 1365             


Pro Glu  Thr Thr Ala Lys Thr  Ile Val Leu Val Lys  Asn Val Leu 
    1370                 1375                 1380             


Ser Arg  His Tyr Val His Leu  Glu Arg Ser Pro Trp  Lys Gly Leu 
    1385                 1390                 1395             


Pro Glu  Leu Thr Asn Glu Asn  Ala Gln Tyr Cys Pro  Phe Ser Cys 
    1400                 1405                 1410             


Glu Thr  Gln Ala Trp Ser Ile  Ala Thr Ile Leu Glu  Thr Leu Tyr 
    1415                 1420                 1425             


Asp Leu  
    1430 


<210>  52
<211>  1404
<212>  PRT
<213>  artificial

<220>
<223>  D1c + D2,3 hGDE

<400>  52

Met Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu 
1               5                   10                  15      


Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe 
            20                  25                  30          


Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala 
        35                  40                  45              


Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr 
    50                  55                  60                  


Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp 
65                  70                  75                  80  


Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn 
                85                  90                  95      


Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn 
            100                 105                 110         


Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg 
        115                 120                 125             


Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro 
    130                 135                 140                 


Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile 
145                 150                 155                 160 


Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val 
                165                 170                 175     


Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu 
            180                 185                 190         


Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile 
        195                 200                 205             


Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile 
    210                 215                 220                 


Ala Leu Thr Thr Phe Ile Pro His Asp Lys Gly Pro Ala Ala Ile Glu 
225                 230                 235                 240 


Glu Cys Cys Asn Trp Phe His Lys Arg Met Glu Glu Leu Asn Ser Glu 
                245                 250                 255     


Lys His Arg Leu Ile Asn Tyr His Gln Glu Gln Ala Val Asn Cys Leu 
            260                 265                 270         


Leu Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His Gly Pro Lys Leu 
        275                 280                 285             


Gly Pro Val Thr Arg Lys His Pro Leu Val Thr Arg Tyr Phe Thr Phe 
    290                 295                 300                 


Pro Phe Glu Glu Ile Asp Phe Ser Met Glu Glu Ser Met Ile His Leu 
305                 310                 315                 320 


Pro Asn Lys Ala Cys Phe Leu Met Ala His Asn Gly Trp Val Met Gly 
                325                 330                 335     


Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu 
            340                 345                 350         


Arg Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly 
        355                 360                 365             


Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr 
    370                 375                 380                 


Thr Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys 
385                 390                 395                 400 


His Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg 
                405                 410                 415     


Asn Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser 
            420                 425                 430         


Glu Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu 
        435                 440                 445             


Ile Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu 
    450                 455                 460                 


Val Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys 
465                 470                 475                 480 


Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile 
                485                 490                 495     


Thr His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala 
            500                 505                 510         


Leu Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser 
        515                 520                 525             


Thr Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile Ser Val Val Ser 
    530                 535                 540                 


Glu Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu Ala Leu Pro Ser Asn 
545                 550                 555                 560 


Thr Gly Glu Val Asn Phe Gln Ser Gly Ile Ile Ala Ala Arg Cys Ala 
                565                 570                 575     


Ile Ser Lys Leu His Gln Glu Leu Gly Ala Lys Gly Phe Ile Gln Val 
            580                 585                 590         


Tyr Val Asp Gln Val Asp Glu Asp Ile Val Ala Val Thr Arg His Ser 
        595                 600                 605             


Pro Ser Ile His Gln Ser Val Val Ala Val Thr Arg Thr Ala Phe Arg 
    610                 615                 620                 


Asn Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val Pro Gln Met Cys Ile 
625                 630                 635                 640 


Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg Thr Ile Glu Arg 
                645                 650                 655     


Asn Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro 
            660                 665                 670         


Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu Asn Glu Ser Lys 
        675                 680                 685             


Ile Val Lys Gln Ala Gly Val Ala Thr Lys Gly Pro Asn Glu Tyr Ile 
    690                 695                 700                 


Gln Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly Ser Val Ile Ile Phe 
705                 710                 715                 720 


Arg Val Ser Leu Asp Pro His Ala Gln Val Ala Val Gly Ile Leu Arg 
                725                 730                 735     


Asn His Leu Thr Gln Phe Ser Pro His Phe Lys Ser Gly Ser Leu Ala 
            740                 745                 750         


Val Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro Phe Ala Ser Leu Ala 
        755                 760                 765             


Tyr Arg Leu Thr Leu Ala Glu Leu Asn Gln Ile Leu Tyr Arg Cys Glu 
    770                 775                 780                 


Ser Glu Glu Lys Glu Asp Gly Gly Gly Cys Tyr Asp Ile Pro Asn Trp 
785                 790                 795                 800 


Ser Ala Leu Lys Tyr Ala Gly Leu Gln Gly Leu Met Ser Val Leu Ala 
                805                 810                 815     


Glu Ile Arg Pro Lys Asn Asp Leu Gly His Pro Phe Cys Asn Asn Leu 
            820                 825                 830         


Arg Ser Gly Asp Trp Met Ile Asp Tyr Val Ser Asn Arg Leu Ile Ser 
        835                 840                 845             


Arg Ser Gly Thr Ile Ala Glu Val Gly Lys Trp Leu Gln Ala Met Phe 
    850                 855                 860                 


Phe Tyr Leu Lys Gln Ile Pro Arg Tyr Leu Ile Pro Cys Tyr Phe Asp 
865                 870                 875                 880 


Ala Ile Leu Ile Gly Ala Tyr Thr Thr Leu Leu Asp Thr Ala Trp Lys 
                885                 890                 895     


Gln Met Ser Ser Phe Val Gln Asn Gly Ser Thr Phe Val Lys His Leu 
            900                 905                 910         


Ser Leu Gly Ser Val Gln Leu Cys Gly Val Gly Lys Phe Pro Ser Leu 
        915                 920                 925             


Pro Ile Leu Ser Pro Ala Leu Met Asp Val Pro Tyr Arg Leu Asn Glu 
    930                 935                 940                 


Ile Thr Lys Glu Lys Glu Gln Cys Cys Val Ser Leu Ala Ala Gly Leu 
945                 950                 955                 960 


Pro His Phe Ser Ser Gly Ile Phe Arg Cys Trp Gly Arg Asp Thr Phe 
                965                 970                 975     


Ile Ala Leu Arg Gly Ile Leu Leu Ile Thr Gly Arg Tyr Val Glu Ala 
            980                 985                 990         


Arg Asn Ile Ile Leu Ala Phe Ala  Gly Thr Leu Arg His  Gly Leu Ile 
        995                 1000                 1005             


Pro Asn  Leu Leu Gly Glu Gly  Ile Tyr Ala Arg Tyr  Asn Cys Arg 
    1010                 1015                 1020             


Asp Ala  Val Trp Trp Trp Leu  Gln Cys Ile Gln Asp  Tyr Cys Lys 
    1025                 1030                 1035             


Met Val  Pro Asn Gly Leu Asp  Ile Leu Lys Cys Pro  Val Ser Arg 
    1040                 1045                 1050             


Met Tyr  Pro Thr Asp Asp Ser  Ala Pro Leu Pro Ala  Gly Thr Leu 
    1055                 1060                 1065             


Asp Gln  Pro Leu Phe Glu Val  Ile Gln Glu Ala Met  Gln Lys His 
    1070                 1075                 1080             


Met Gln  Gly Ile Gln Phe Arg  Glu Arg Asn Ala Gly  Pro Gln Ile 
    1085                 1090                 1095             


Asp Arg  Asn Met Lys Asp Glu  Gly Phe Asn Ile Thr  Ala Gly Val 
    1100                 1105                 1110             


Asp Glu  Glu Thr Gly Phe Val  Tyr Gly Gly Asn Arg  Phe Asn Cys 
    1115                 1120                 1125             


Gly Thr  Trp Met Asp Lys Met  Gly Glu Ser Asp Arg  Ala Arg Asn 
    1130                 1135                 1140             


Arg Gly  Ile Pro Ala Thr Pro  Arg Asp Gly Ser Ala  Val Glu Ile 
    1145                 1150                 1155             


Val Gly  Leu Ser Lys Ser Ala  Val Arg Trp Leu Leu  Glu Leu Ser 
    1160                 1165                 1170             


Lys Lys  Asn Ile Phe Pro Tyr  His Glu Val Thr Val  Lys Arg His 
    1175                 1180                 1185             


Gly Lys  Ala Ile Lys Val Ser  Tyr Asp Glu Trp Asn  Arg Lys Ile 
    1190                 1195                 1200             


Gln Asp  Asn Phe Glu Lys Leu  Phe His Val Ser Glu  Asp Pro Ser 
    1205                 1210                 1215             


Asp Leu  Asn Glu Lys His Pro  Asn Leu Val His Lys  Arg Gly Ile 
    1220                 1225                 1230             


Tyr Lys  Asp Ser Tyr Gly Ala  Ser Ser Pro Trp Cys  Asp Tyr Gln 
    1235                 1240                 1245             


Leu Arg  Pro Asn Phe Thr Ile  Ala Met Val Val Ala  Pro Glu Leu 
    1250                 1255                 1260             


Phe Thr  Thr Glu Lys Ala Trp  Lys Ala Leu Glu Ile  Ala Glu Lys 
    1265                 1270                 1275             


Lys Leu  Leu Gly Pro Leu Gly  Met Lys Thr Leu Asp  Pro Asp Asp 
    1280                 1285                 1290             


Met Val  Tyr Cys Gly Ile Tyr  Asp Asn Ala Leu Asp  Asn Asp Asn 
    1295                 1300                 1305             


Tyr Asn  Leu Ala Lys Gly Phe  Asn Tyr His Gln Gly  Pro Glu Trp 
    1310                 1315                 1320             


Leu Trp  Pro Ile Gly Tyr Phe  Leu Arg Ala Lys Leu  Tyr Phe Ser 
    1325                 1330                 1335             


Arg Leu  Met Gly Pro Glu Thr  Thr Ala Lys Thr Ile  Val Leu Val 
    1340                 1345                 1350             


Lys Asn  Val Leu Ser Arg His  Tyr Val His Leu Glu  Arg Ser Pro 
    1355                 1360                 1365             


Trp Lys  Gly Leu Pro Glu Leu  Thr Asn Glu Asn Ala  Gln Tyr Cys 
    1370                 1375                 1380             


Pro Phe  Ser Cys Glu Thr Gln  Ala Trp Ser Ile Ala  Thr Ile Leu 
    1385                 1390                 1395             


Glu Thr  Leu Tyr Asp Leu 
    1400                 


<210>  53
<211>  4557
<212>  DNA
<213>  artificial

<220>
<223>  D1a + D2,3 hGDE

<400>  53
atggaaaagc tggaaaagac cctgttccgg ctcgagcagg gctacgagct gcagtttaga       60

ctgggcccta cactgcaggg caaagccgtg accgtgtaca caaactaccc cttccctggc      120

gaaaccttca accgcgagaa gttcagaagc ctggactggg agaaccccac cgagagagag      180

gacgacagcg acaagtactg caagctgaac ctgcagcaga gcggctcctt ccagtactac      240

ttcctgcaag gcaacgagaa gtccggcgga ggctacatcg tggtggaccc tattctgaga      300

gtgggcgccg acaatcacgt gctgcctctg gattgtgtga ccctgcagac cttcctggcc      360

aagtgtctgg gccctttcga tgagtgggag agcagactgc gcgtggccaa agaaagcggc      420

tacaacatga tccacttcac ccctctgcag accctgggcc tgagcagaag ctgttacagc      480

ctggccaacc agctggaact gaaccccgac ttcagcagac ccaaccggaa gtacacctgg      540

aacgatgtgg gccagctggt ggaaaaactg aagaaagaat ggaacgtgat ctgcatcacc      600

gacgtggtgt acaaccacac cgccgccaac agcaagtgga tccaagagca ccctgagtgc      660

gcctacaacc tggtcaacag ccctcacctg aaacctgcct gggtgctcga tagagccctg      720

tggcggttta gctgtgatgt ggccgagggc aagtacaaag agaagggcat ccccgctctg      780

atcgagaacg accaccacat gaacagcatc cggaagatca tctgggaaga tattttcccc      840

aagctgaagc tgtgggagtt cttccaggtg gacgtgaaca aggccgtgga acagttcaga      900

cggctgctga cccaagagaa cagaagagtg accaagagcg accccaacca gcacctgacc      960

atcattcagg accccgagta tcggagattc ggctgcaccg tggacatgaa tatcgccctg     1020

accaccttca ttccccacga caaaggacct gccgccatcg aggaatgctg caactggttc     1080

cacaagcgga tggaagaatt gaacagcgag aagcaccggc tgatcaacta ccaccaagag     1140

caggccgtga actgcctgct gggcaacgtg ttctatgaga gactggccgg acacggccct     1200

aagctgggac ctgtgacaag aaagcaccct ctggttaccc ggtacttcac ctttccattc     1260

gaagagatcg acttctccat ggaagagagc atgatccatc tgcctaacaa ggcctgcttc     1320

ctgatggctc acaacggctg ggttatgggc gacgaccctc tgagaaattt cgccgagcct     1380

ggcagcgagg tgtacctgag aagagaactg atctgttggg gcgacagcgt gaagctgaga     1440

tacggcaaca agcccgagga ctgcccttac ctgtgggccc atatgaagaa gtacacagag     1500

atcaccgcca cctactttca gggcgtcaga ctggacaact gccacagcac acctctgcac     1560

gtggccgagt acatgctgga cgccgctaga aatctgcagc ccaacctgta tgtggtggcc     1620

gagctgttta ccggctccga ggacctggac aatgtgttcg tgaccagact gggcatcagc     1680

agcctgatca gagaagccat gtccgcctac aatagccacg aagagggcag actggtgtac     1740

agatatggcg gcgagcctgt gggcagcttc gttcagcctt gtctgaggcc tctgatgccc     1800

gccattgctc acgccctgtt catggacatc acccacgata acgagtgccc catcgtgcac     1860

agaagcgcct acgacgctct gcctagcacc accattgtgt ccatggcctg ttgtgccagc     1920

ggcagcacaa gaggctatga cgaactggtg ccccaccaga tttccgtggt gtccgaggaa     1980

cggttctaca ccaagtggaa ccccgaggct ctgcccagca ataccggcga agtgaatttc     2040

cagagcggca tcattgccgc cagatgcgcc atcagcaagc tgcaccaaga actgggcgcc     2100

aagggcttca ttcaggtgta cgtggaccag gtcgacgagg acattgtggc cgtgacaaga     2160

cacagcccca gcatccatca gagcgtggtg gctgtgacca gaaccgcctt cagaaacccc     2220

aagaccagct tctacagcaa agaggtgccc cagatgtgca tccccggcaa gattgaggaa     2280

gtggtgctcg aggcccggac catcgagaga aacaccaagc cttaccggaa ggacgagaac     2340

tccatcaacg gcacccctga catcaccgtg gaaatcagag agcacatcca gctcaacgag     2400

agcaagatcg tgaaacaggc cggcgtggcc acaaagggcc ccaacgagta tatccaagag     2460

attgagttcg agaatctgag ccccggcagc gtgatcatct tcagagtgtc cctggatcct     2520

cacgctcagg tggccgtggg catcctgaga aatcacctga cacagttcag cccacacttc     2580

aagagcggaa gcctggccgt ggacaacgcc gatcctatcc tgaagatccc cttcgcctct     2640

ctggcctaca gactgacact ggctgagctg aaccagatcc tgtacagatg cgagtccgaa     2700

gagaaagagg atggcggagg ctgctacgac atccccaatt ggagcgccct gaagtatgcc     2760

ggactgcagg gactgatgtc tgtgctggcc gagatcagac ccaagaacga cctgggacac     2820

cccttctgca acaacctgag atccggcgac tggatgatcg actacgtgtc caacagactg     2880

atcagcagat ccggcacaat cgccgaagtc ggcaaatggc tgcaggccat gttcttctac     2940

ctgaagcaga tccctcggta tctgatcccc tgctacttcg acgccatcct gatcggcgcc     3000

tacaccacac tgctggatac cgcctggaag cagatgtcca gcttcgtgca gaacggcagc     3060

accttcgtga agcacctgtc tctgggaagc gtgcagctgt gtggcgtggg caaatttccc     3120

agcctgccta tcctgtctcc tgcactgatg gacgtgccct accggctgaa tgagatcacc     3180

aaagaaaaag agcagtgctg cgtcagcctg gctgctggcc tgcctcattt ttccagcggc     3240

atcttccggt gttggggcag agacaccttt attgccctga gaggcatcct gctgattacc     3300

ggcagatacg tggaagcccg gaacatcatc ctggcctttg ccggcacact gcggcacgga     3360

ctgattccta atctgctcgg cgagggcatc tacgccagat acaactgcag agatgccgtg     3420

tggtggtggc tccagtgcat ccaggactac tgcaagatgg tgcccaacgg cctggacatc     3480

ctgaagtgcc ctgtgtccag aatgtaccct accgacgata gcgcccctct gcctgccgga     3540

acacttgacc agcctctgtt cgaagtgatt caagaggcca tgcagaaaca catgcaggga     3600

atccagtttc gcgagcggaa tgccggacct cagatcgaca gaaacatgaa ggatgagggc     3660

ttcaacatca ccgctggcgt ggacgaagag acaggctttg tgtacggcgg caaccggttc     3720

aattgcggca cctggatgga caagatgggc gagtctgacc gggccagaaa cagaggaatt     3780

cccgccacac ctagagatgg cagcgctgtg gaaatcgtgg gcctgtctaa gtctgctgtg     3840

cggtggctgc tcgaactgag caagaagaat atctttccgt accacgaagt gaccgtgaag     3900

cggcacggca aggccatcaa ggtgtcctac gacgagtgga acagaaagat ccaggacaac     3960

ttcgaaaagc tgttccatgt gtctgaggac cccagcgacc tgaacgaaaa gcaccccaac     4020

ctggtgcaca agcgcggcat ctacaaggac agctacggcg cctcttctcc ttggtgcgat     4080

taccagctgc ggcccaactt caccattgcc atggtggttg cccctgagct gttcaccaca     4140

gagaaggcct ggaaggccct ggaaatcgcc gagaagaaac tgctgggccc tctgggcatg     4200

aagacactgg accccgacga catggtgtac tgcggaatct acgacaacgc cctggataac     4260

gacaactaca atctggccaa ggggttcaat taccatcagg gacccgagtg gctgtggcct     4320

atcggctatt tcctgcgggc caagctgtac ttctccagac tgatgggccc tgagacaacc     4380

gccaagacaa tcgtgctcgt gaagaacgtg ctgagccggc actatgtgca cctggaaaga     4440

agcccctgga agggactgcc cgagctgacc aatgagaacg cccagtactg ccccttcagc     4500

tgcgaaacac aggcctggtc tatcgccacc atcctggaaa ccctgtacga cctgtga        4557


<210>  54
<211>  4512
<212>  DNA
<213>  artificial

<220>
<223>  D1b1 + D2,3 hGDE

<400>  54
atgctgcagt ttagactggg ccctacactg cagggcaaag ccgtgaccgt gtacacaaac       60

taccccttcc ctggcgaaac cttcaaccgc gagaagttca gaagcctgga ctgggagaac      120

cccaccgaga gagaggacga cagcgacaag tactgcaagc tgaacctgca gcagagcggc      180

tccttccagt actacttcct gcaaggcaac gagaagtccg gcggaggcta catcgtggtg      240

gaccctattc tgagagtggg cgccgacaat cacgtgctgc ctctggattg tgtgaccctg      300

cagaccttcc tggccaagtg tctgggccct ttcgatgagt gggagagcag actgcgcgtg      360

gccaaagaaa gcggctacaa catgatccac ttcacccctc tgcagaccct gggcctgagc      420

agaagctgtt acagcctggc caaccagctg gaactgaacc ccgacttcag cagacccaac      480

cggaagtaca cctggaacga tgtgggccag ctggtggaaa aactgaagaa agaatggaac      540

gtgatctgca tcaccgacgt ggtgtacaac cacaccgccg ccaacagcaa gtggatccaa      600

gagcaccctg agtgcgccta caacctggtc aacagccctc acctgaaacc tgcctgggtg      660

ctcgatagag ccctgtggcg gtttagctgt gatgtggccg agggcaagta caaagagaag      720

ggcatccccg ctctgatcga gaacgaccac cacatgaaca gcatccggaa gatcatctgg      780

gaagatattt tccccaagct gaagctgtgg gagttcttcc aggtggacgt gaacaaggcc      840

gtggaacagt tcagacggct gctgacccaa gagaacagaa gagtgaccaa gagcgacccc      900

aaccagcacc tgaccatcat tcaggacccc gagtatcgga gattcggctg caccgtggac      960

atgaatatcg ccctgaccac cttcattccc cacgacaaag gacctgccgc catcgaggaa     1020

tgctgcaact ggttccacaa gcggatggaa gaattgaaca gcgagaagca ccggctgatc     1080

aactaccacc aagagcaggc cgtgaactgc ctgctgggca acgtgttcta tgagagactg     1140

gccggacacg gccctaagct gggacctgtg acaagaaagc accctctggt tacccggtac     1200

ttcacctttc cattcgaaga gatcgacttc tccatggaag agagcatgat ccatctgcct     1260

aacaaggcct gcttcctgat ggctcacaac ggctgggtta tgggcgacga ccctctgaga     1320

aatttcgccg agcctggcag cgaggtgtac ctgagaagag aactgatctg ttggggcgac     1380

agcgtgaagc tgagatacgg caacaagccc gaggactgcc cttacctgtg ggcccatatg     1440

aagaagtaca cagagatcac cgccacctac tttcagggcg tcagactgga caactgccac     1500

agcacacctc tgcacgtggc cgagtacatg ctggacgccg ctagaaatct gcagcccaac     1560

ctgtatgtgg tggccgagct gtttaccggc tccgaggacc tggacaatgt gttcgtgacc     1620

agactgggca tcagcagcct gatcagagaa gccatgtccg cctacaatag ccacgaagag     1680

ggcagactgg tgtacagata tggcggcgag cctgtgggca gcttcgttca gccttgtctg     1740

aggcctctga tgcccgccat tgctcacgcc ctgttcatgg acatcaccca cgataacgag     1800

tgccccatcg tgcacagaag cgcctacgac gctctgccta gcaccaccat tgtgtccatg     1860

gcctgttgtg ccagcggcag cacaagaggc tatgacgaac tggtgcccca ccagatttcc     1920

gtggtgtccg aggaacggtt ctacaccaag tggaaccccg aggctctgcc cagcaatacc     1980

ggcgaagtga atttccagag cggcatcatt gccgccagat gcgccatcag caagctgcac     2040

caagaactgg gcgccaaggg cttcattcag gtgtacgtgg accaggtcga cgaggacatt     2100

gtggccgtga caagacacag ccccagcatc catcagagcg tggtggctgt gaccagaacc     2160

gccttcagaa accccaagac cagcttctac agcaaagagg tgccccagat gtgcatcccc     2220

ggcaagattg aggaagtggt gctcgaggcc cggaccatcg agagaaacac caagccttac     2280

cggaaggacg agaactccat caacggcacc cctgacatca ccgtggaaat cagagagcac     2340

atccagctca acgagagcaa gatcgtgaaa caggccggcg tggccacaaa gggccccaac     2400

gagtatatcc aagagattga gttcgagaat ctgagccccg gcagcgtgat catcttcaga     2460

gtgtccctgg atcctcacgc tcaggtggcc gtgggcatcc tgagaaatca cctgacacag     2520

ttcagcccac acttcaagag cggaagcctg gccgtggaca acgccgatcc tatcctgaag     2580

atccccttcg cctctctggc ctacagactg acactggctg agctgaacca gatcctgtac     2640

agatgcgagt ccgaagagaa agaggatggc ggaggctgct acgacatccc caattggagc     2700

gccctgaagt atgccggact gcagggactg atgtctgtgc tggccgagat cagacccaag     2760

aacgacctgg gacacccctt ctgcaacaac ctgagatccg gcgactggat gatcgactac     2820

gtgtccaaca gactgatcag cagatccggc acaatcgccg aagtcggcaa atggctgcag     2880

gccatgttct tctacctgaa gcagatccct cggtatctga tcccctgcta cttcgacgcc     2940

atcctgatcg gcgcctacac cacactgctg gataccgcct ggaagcagat gtccagcttc     3000

gtgcagaacg gcagcacctt cgtgaagcac ctgtctctgg gaagcgtgca gctgtgtggc     3060

gtgggcaaat ttcccagcct gcctatcctg tctcctgcac tgatggacgt gccctaccgg     3120

ctgaatgaga tcaccaaaga aaaagagcag tgctgcgtca gcctggctgc tggcctgcct     3180

catttttcca gcggcatctt ccggtgttgg ggcagagaca cctttattgc cctgagaggc     3240

atcctgctga ttaccggcag atacgtggaa gcccggaaca tcatcctggc ctttgccggc     3300

acactgcggc acggactgat tcctaatctg ctcggcgagg gcatctacgc cagatacaac     3360

tgcagagatg ccgtgtggtg gtggctccag tgcatccagg actactgcaa gatggtgccc     3420

aacggcctgg acatcctgaa gtgccctgtg tccagaatgt accctaccga cgatagcgcc     3480

cctctgcctg ccggaacact tgaccagcct ctgttcgaag tgattcaaga ggccatgcag     3540

aaacacatgc agggaatcca gtttcgcgag cggaatgccg gacctcagat cgacagaaac     3600

atgaaggatg agggcttcaa catcaccgct ggcgtggacg aagagacagg ctttgtgtac     3660

ggcggcaacc ggttcaattg cggcacctgg atggacaaga tgggcgagtc tgaccgggcc     3720

agaaacagag gaattcccgc cacacctaga gatggcagcg ctgtggaaat cgtgggcctg     3780

tctaagtctg ctgtgcggtg gctgctcgaa ctgagcaaga agaatatctt tccgtaccac     3840

gaagtgaccg tgaagcggca cggcaaggcc atcaaggtgt cctacgacga gtggaacaga     3900

aagatccagg acaacttcga aaagctgttc catgtgtctg aggaccccag cgacctgaac     3960

gaaaagcacc ccaacctggt gcacaagcgc ggcatctaca aggacagcta cggcgcctct     4020

tctccttggt gcgattacca gctgcggccc aacttcacca ttgccatggt ggttgcccct     4080

gagctgttca ccacagagaa ggcctggaag gccctggaaa tcgccgagaa gaaactgctg     4140

ggccctctgg gcatgaagac actggacccc gacgacatgg tgtactgcgg aatctacgac     4200

aacgccctgg ataacgacaa ctacaatctg gccaaggggt tcaattacca tcagggaccc     4260

gagtggctgt ggcctatcgg ctatttcctg cgggccaagc tgtacttctc cagactgatg     4320

ggccctgaga caaccgccaa gacaatcgtg ctcgtgaaga acgtgctgag ccggcactat     4380

gtgcacctgg aaagaagccc ctggaaggga ctgcccgagc tgaccaatga gaacgcccag     4440

tactgcccct tcagctgcga aacacaggcc tggtctatcg ccaccatcct ggaaaccctg     4500

tacgacctgt ga                                                         4512


<210>  55
<211>  4359
<212>  DNA
<213>  artificial

<220>
<223>  D1b2 + D2,3 hGDE

<400>  55
atgaagctga acctgcagca gagcggctcc ttccagtact acttcctgca aggcaacgag       60

aagtccggcg gaggctacat cgtggtggac cctattctga gagtgggcgc cgacaatcac      120

gtgctgcctc tggattgtgt gaccctgcag accttcctgg ccaagtgtct gggccctttc      180

gatgagtggg agagcagact gcgcgtggcc aaagaaagcg gctacaacat gatccacttc      240

acccctctgc agaccctggg cctgagcaga agctgttaca gcctggccaa ccagctggaa      300

ctgaaccccg acttcagcag acccaaccgg aagtacacct ggaacgatgt gggccagctg      360

gtggaaaaac tgaagaaaga atggaacgtg atctgcatca ccgacgtggt gtacaaccac      420

accgccgcca acagcaagtg gatccaagag caccctgagt gcgcctacaa cctggtcaac      480

agccctcacc tgaaacctgc ctgggtgctc gatagagccc tgtggcggtt tagctgtgat      540

gtggccgagg gcaagtacaa agagaagggc atccccgctc tgatcgagaa cgaccaccac      600

atgaacagca tccggaagat catctgggaa gatattttcc ccaagctgaa gctgtgggag      660

ttcttccagg tggacgtgaa caaggccgtg gaacagttca gacggctgct gacccaagag      720

aacagaagag tgaccaagag cgaccccaac cagcacctga ccatcattca ggaccccgag      780

tatcggagat tcggctgcac cgtggacatg aatatcgccc tgaccacctt cattccccac      840

gacaaaggac ctgccgccat cgaggaatgc tgcaactggt tccacaagcg gatggaagaa      900

ttgaacagcg agaagcaccg gctgatcaac taccaccaag agcaggccgt gaactgcctg      960

ctgggcaacg tgttctatga gagactggcc ggacacggcc ctaagctggg acctgtgaca     1020

agaaagcacc ctctggttac ccggtacttc acctttccat tcgaagagat cgacttctcc     1080

atggaagaga gcatgatcca tctgcctaac aaggcctgct tcctgatggc tcacaacggc     1140

tgggttatgg gcgacgaccc tctgagaaat ttcgccgagc ctggcagcga ggtgtacctg     1200

agaagagaac tgatctgttg gggcgacagc gtgaagctga gatacggcaa caagcccgag     1260

gactgccctt acctgtgggc ccatatgaag aagtacacag agatcaccgc cacctacttt     1320

cagggcgtca gactggacaa ctgccacagc acacctctgc acgtggccga gtacatgctg     1380

gacgccgcta gaaatctgca gcccaacctg tatgtggtgg ccgagctgtt taccggctcc     1440

gaggacctgg acaatgtgtt cgtgaccaga ctgggcatca gcagcctgat cagagaagcc     1500

atgtccgcct acaatagcca cgaagagggc agactggtgt acagatatgg cggcgagcct     1560

gtgggcagct tcgttcagcc ttgtctgagg cctctgatgc ccgccattgc tcacgccctg     1620

ttcatggaca tcacccacga taacgagtgc cccatcgtgc acagaagcgc ctacgacgct     1680

ctgcctagca ccaccattgt gtccatggcc tgttgtgcca gcggcagcac aagaggctat     1740

gacgaactgg tgccccacca gatttccgtg gtgtccgagg aacggttcta caccaagtgg     1800

aaccccgagg ctctgcccag caataccggc gaagtgaatt tccagagcgg catcattgcc     1860

gccagatgcg ccatcagcaa gctgcaccaa gaactgggcg ccaagggctt cattcaggtg     1920

tacgtggacc aggtcgacga ggacattgtg gccgtgacaa gacacagccc cagcatccat     1980

cagagcgtgg tggctgtgac cagaaccgcc ttcagaaacc ccaagaccag cttctacagc     2040

aaagaggtgc cccagatgtg catccccggc aagattgagg aagtggtgct cgaggcccgg     2100

accatcgaga gaaacaccaa gccttaccgg aaggacgaga actccatcaa cggcacccct     2160

gacatcaccg tggaaatcag agagcacatc cagctcaacg agagcaagat cgtgaaacag     2220

gccggcgtgg ccacaaaggg ccccaacgag tatatccaag agattgagtt cgagaatctg     2280

agccccggca gcgtgatcat cttcagagtg tccctggatc ctcacgctca ggtggccgtg     2340

ggcatcctga gaaatcacct gacacagttc agcccacact tcaagagcgg aagcctggcc     2400

gtggacaacg ccgatcctat cctgaagatc cccttcgcct ctctggccta cagactgaca     2460

ctggctgagc tgaaccagat cctgtacaga tgcgagtccg aagagaaaga ggatggcgga     2520

ggctgctacg acatccccaa ttggagcgcc ctgaagtatg ccggactgca gggactgatg     2580

tctgtgctgg ccgagatcag acccaagaac gacctgggac accccttctg caacaacctg     2640

agatccggcg actggatgat cgactacgtg tccaacagac tgatcagcag atccggcaca     2700

atcgccgaag tcggcaaatg gctgcaggcc atgttcttct acctgaagca gatccctcgg     2760

tatctgatcc cctgctactt cgacgccatc ctgatcggcg cctacaccac actgctggat     2820

accgcctgga agcagatgtc cagcttcgtg cagaacggca gcaccttcgt gaagcacctg     2880

tctctgggaa gcgtgcagct gtgtggcgtg ggcaaatttc ccagcctgcc tatcctgtct     2940

cctgcactga tggacgtgcc ctaccggctg aatgagatca ccaaagaaaa agagcagtgc     3000

tgcgtcagcc tggctgctgg cctgcctcat ttttccagcg gcatcttccg gtgttggggc     3060

agagacacct ttattgccct gagaggcatc ctgctgatta ccggcagata cgtggaagcc     3120

cggaacatca tcctggcctt tgccggcaca ctgcggcacg gactgattcc taatctgctc     3180

ggcgagggca tctacgccag atacaactgc agagatgccg tgtggtggtg gctccagtgc     3240

atccaggact actgcaagat ggtgcccaac ggcctggaca tcctgaagtg ccctgtgtcc     3300

agaatgtacc ctaccgacga tagcgcccct ctgcctgccg gaacacttga ccagcctctg     3360

ttcgaagtga ttcaagaggc catgcagaaa cacatgcagg gaatccagtt tcgcgagcgg     3420

aatgccggac ctcagatcga cagaaacatg aaggatgagg gcttcaacat caccgctggc     3480

gtggacgaag agacaggctt tgtgtacggc ggcaaccggt tcaattgcgg cacctggatg     3540

gacaagatgg gcgagtctga ccgggccaga aacagaggaa ttcccgccac acctagagat     3600

ggcagcgctg tggaaatcgt gggcctgtct aagtctgctg tgcggtggct gctcgaactg     3660

agcaagaaga atatctttcc gtaccacgaa gtgaccgtga agcggcacgg caaggccatc     3720

aaggtgtcct acgacgagtg gaacagaaag atccaggaca acttcgaaaa gctgttccat     3780

gtgtctgagg accccagcga cctgaacgaa aagcacccca acctggtgca caagcgcggc     3840

atctacaagg acagctacgg cgcctcttct ccttggtgcg attaccagct gcggcccaac     3900

ttcaccattg ccatggtggt tgcccctgag ctgttcacca cagagaaggc ctggaaggcc     3960

ctggaaatcg ccgagaagaa actgctgggc cctctgggca tgaagacact ggaccccgac     4020

gacatggtgt actgcggaat ctacgacaac gccctggata acgacaacta caatctggcc     4080

aaggggttca attaccatca gggacccgag tggctgtggc ctatcggcta tttcctgcgg     4140

gccaagctgt acttctccag actgatgggc cctgagacaa ccgccaagac aatcgtgctc     4200

gtgaagaacg tgctgagccg gcactatgtg cacctggaaa gaagcccctg gaagggactg     4260

cccgagctga ccaatgagaa cgcccagtac tgccccttca gctgcgaaac acaggcctgg     4320

tctatcgcca ccatcctgga aaccctgtac gacctgtga                            4359


<210>  56
<211>  4293
<212>  DNA
<213>  artificial

<220>
<223>  D1b3 + D2,3 hGDE

<400>  56
atgggaggct acatcgtggt ggaccctatt ctgagagtgg gcgccgacaa tcacgtgctg       60

cctctggatt gtgtgaccct gcagaccttc ctggccaagt gtctgggccc tttcgatgag      120

tgggagagca gactgcgcgt ggccaaagaa agcggctaca acatgatcca cttcacccct      180

ctgcagaccc tgggcctgag cagaagctgt tacagcctgg ccaaccagct ggaactgaac      240

cccgacttca gcagacccaa ccggaagtac acctggaacg atgtgggcca gctggtggaa      300

aaactgaaga aagaatggaa cgtgatctgc atcaccgacg tggtgtacaa ccacaccgcc      360

gccaacagca agtggatcca agagcaccct gagtgcgcct acaacctggt caacagccct      420

cacctgaaac ctgcctgggt gctcgataga gccctgtggc ggtttagctg tgatgtggcc      480

gagggcaagt acaaagagaa gggcatcccc gctctgatcg agaacgacca ccacatgaac      540

agcatccgga agatcatctg ggaagatatt ttccccaagc tgaagctgtg ggagttcttc      600

caggtggacg tgaacaaggc cgtggaacag ttcagacggc tgctgaccca agagaacaga      660

agagtgacca agagcgaccc caaccagcac ctgaccatca ttcaggaccc cgagtatcgg      720

agattcggct gcaccgtgga catgaatatc gccctgacca ccttcattcc ccacgacaaa      780

ggacctgccg ccatcgagga atgctgcaac tggttccaca agcggatgga agaattgaac      840

agcgagaagc accggctgat caactaccac caagagcagg ccgtgaactg cctgctgggc      900

aacgtgttct atgagagact ggccggacac ggccctaagc tgggacctgt gacaagaaag      960

caccctctgg ttacccggta cttcaccttt ccattcgaag agatcgactt ctccatggaa     1020

gagagcatga tccatctgcc taacaaggcc tgcttcctga tggctcacaa cggctgggtt     1080

atgggcgacg accctctgag aaatttcgcc gagcctggca gcgaggtgta cctgagaaga     1140

gaactgatct gttggggcga cagcgtgaag ctgagatacg gcaacaagcc cgaggactgc     1200

ccttacctgt gggcccatat gaagaagtac acagagatca ccgccaccta ctttcagggc     1260

gtcagactgg acaactgcca cagcacacct ctgcacgtgg ccgagtacat gctggacgcc     1320

gctagaaatc tgcagcccaa cctgtatgtg gtggccgagc tgtttaccgg ctccgaggac     1380

ctggacaatg tgttcgtgac cagactgggc atcagcagcc tgatcagaga agccatgtcc     1440

gcctacaata gccacgaaga gggcagactg gtgtacagat atggcggcga gcctgtgggc     1500

agcttcgttc agccttgtct gaggcctctg atgcccgcca ttgctcacgc cctgttcatg     1560

gacatcaccc acgataacga gtgccccatc gtgcacagaa gcgcctacga cgctctgcct     1620

agcaccacca ttgtgtccat ggcctgttgt gccagcggca gcacaagagg ctatgacgaa     1680

ctggtgcccc accagatttc cgtggtgtcc gaggaacggt tctacaccaa gtggaacccc     1740

gaggctctgc ccagcaatac cggcgaagtg aatttccaga gcggcatcat tgccgccaga     1800

tgcgccatca gcaagctgca ccaagaactg ggcgccaagg gcttcattca ggtgtacgtg     1860

gaccaggtcg acgaggacat tgtggccgtg acaagacaca gccccagcat ccatcagagc     1920

gtggtggctg tgaccagaac cgccttcaga aaccccaaga ccagcttcta cagcaaagag     1980

gtgccccaga tgtgcatccc cggcaagatt gaggaagtgg tgctcgaggc ccggaccatc     2040

gagagaaaca ccaagcctta ccggaaggac gagaactcca tcaacggcac ccctgacatc     2100

accgtggaaa tcagagagca catccagctc aacgagagca agatcgtgaa acaggccggc     2160

gtggccacaa agggccccaa cgagtatatc caagagattg agttcgagaa tctgagcccc     2220

ggcagcgtga tcatcttcag agtgtccctg gatcctcacg ctcaggtggc cgtgggcatc     2280

ctgagaaatc acctgacaca gttcagccca cacttcaaga gcggaagcct ggccgtggac     2340

aacgccgatc ctatcctgaa gatccccttc gcctctctgg cctacagact gacactggct     2400

gagctgaacc agatcctgta cagatgcgag tccgaagaga aagaggatgg cggaggctgc     2460

tacgacatcc ccaattggag cgccctgaag tatgccggac tgcagggact gatgtctgtg     2520

ctggccgaga tcagacccaa gaacgacctg ggacacccct tctgcaacaa cctgagatcc     2580

ggcgactgga tgatcgacta cgtgtccaac agactgatca gcagatccgg cacaatcgcc     2640

gaagtcggca aatggctgca ggccatgttc ttctacctga agcagatccc tcggtatctg     2700

atcccctgct acttcgacgc catcctgatc ggcgcctaca ccacactgct ggataccgcc     2760

tggaagcaga tgtccagctt cgtgcagaac ggcagcacct tcgtgaagca cctgtctctg     2820

ggaagcgtgc agctgtgtgg cgtgggcaaa tttcccagcc tgcctatcct gtctcctgca     2880

ctgatggacg tgccctaccg gctgaatgag atcaccaaag aaaaagagca gtgctgcgtc     2940

agcctggctg ctggcctgcc tcatttttcc agcggcatct tccggtgttg gggcagagac     3000

acctttattg ccctgagagg catcctgctg attaccggca gatacgtgga agcccggaac     3060

atcatcctgg cctttgccgg cacactgcgg cacggactga ttcctaatct gctcggcgag     3120

ggcatctacg ccagatacaa ctgcagagat gccgtgtggt ggtggctcca gtgcatccag     3180

gactactgca agatggtgcc caacggcctg gacatcctga agtgccctgt gtccagaatg     3240

taccctaccg acgatagcgc ccctctgcct gccggaacac ttgaccagcc tctgttcgaa     3300

gtgattcaag aggccatgca gaaacacatg cagggaatcc agtttcgcga gcggaatgcc     3360

ggacctcaga tcgacagaaa catgaaggat gagggcttca acatcaccgc tggcgtggac     3420

gaagagacag gctttgtgta cggcggcaac cggttcaatt gcggcacctg gatggacaag     3480

atgggcgagt ctgaccgggc cagaaacaga ggaattcccg ccacacctag agatggcagc     3540

gctgtggaaa tcgtgggcct gtctaagtct gctgtgcggt ggctgctcga actgagcaag     3600

aagaatatct ttccgtacca cgaagtgacc gtgaagcggc acggcaaggc catcaaggtg     3660

tcctacgacg agtggaacag aaagatccag gacaacttcg aaaagctgtt ccatgtgtct     3720

gaggacccca gcgacctgaa cgaaaagcac cccaacctgg tgcacaagcg cggcatctac     3780

aaggacagct acggcgcctc ttctccttgg tgcgattacc agctgcggcc caacttcacc     3840

attgccatgg tggttgcccc tgagctgttc accacagaga aggcctggaa ggccctggaa     3900

atcgccgaga agaaactgct gggccctctg ggcatgaaga cactggaccc cgacgacatg     3960

gtgtactgcg gaatctacga caacgccctg gataacgaca actacaatct ggccaagggg     4020

ttcaattacc atcagggacc cgagtggctg tggcctatcg gctatttcct gcgggccaag     4080

ctgtacttct ccagactgat gggccctgag acaaccgcca agacaatcgt gctcgtgaag     4140

aacgtgctga gccggcacta tgtgcacctg gaaagaagcc cctggaaggg actgcccgag     4200

ctgaccaatg agaacgccca gtactgcccc ttcagctgcg aaacacaggc ctggtctatc     4260

gccaccatcc tggaaaccct gtacgacctg tga                                  4293


<210>  57
<211>  4215
<212>  DNA
<213>  artificial

<220>
<223>  D1c + D2,3 hGDE

<400>  57
atgcagacct tcctggccaa gtgtctgggc cctttcgatg agtgggagag cagactgcgc       60

gtggccaaag aaagcggcta caacatgatc cacttcaccc ctctgcagac cctgggcctg      120

agcagaagct gttacagcct ggccaaccag ctggaactga accccgactt cagcagaccc      180

aaccggaagt acacctggaa cgatgtgggc cagctggtgg aaaaactgaa gaaagaatgg      240

aacgtgatct gcatcaccga cgtggtgtac aaccacaccg ccgccaacag caagtggatc      300

caagagcacc ctgagtgcgc ctacaacctg gtcaacagcc ctcacctgaa acctgcctgg      360

gtgctcgata gagccctgtg gcggtttagc tgtgatgtgg ccgagggcaa gtacaaagag      420

aagggcatcc ccgctctgat cgagaacgac caccacatga acagcatccg gaagatcatc      480

tgggaagata ttttccccaa gctgaagctg tgggagttct tccaggtgga cgtgaacaag      540

gccgtggaac agttcagacg gctgctgacc caagagaaca gaagagtgac caagagcgac      600

cccaaccagc acctgaccat cattcaggac cccgagtatc ggagattcgg ctgcaccgtg      660

gacatgaata tcgccctgac caccttcatt ccccacgaca aaggacctgc cgccatcgag      720

gaatgctgca actggttcca caagcggatg gaagaattga acagcgagaa gcaccggctg      780

atcaactacc accaagagca ggccgtgaac tgcctgctgg gcaacgtgtt ctatgagaga      840

ctggccggac acggccctaa gctgggacct gtgacaagaa agcaccctct ggttacccgg      900

tacttcacct ttccattcga agagatcgac ttctccatgg aagagagcat gatccatctg      960

cctaacaagg cctgcttcct gatggctcac aacggctggg ttatgggcga cgaccctctg     1020

agaaatttcg ccgagcctgg cagcgaggtg tacctgagaa gagaactgat ctgttggggc     1080

gacagcgtga agctgagata cggcaacaag cccgaggact gcccttacct gtgggcccat     1140

atgaagaagt acacagagat caccgccacc tactttcagg gcgtcagact ggacaactgc     1200

cacagcacac ctctgcacgt ggccgagtac atgctggacg ccgctagaaa tctgcagccc     1260

aacctgtatg tggtggccga gctgtttacc ggctccgagg acctggacaa tgtgttcgtg     1320

accagactgg gcatcagcag cctgatcaga gaagccatgt ccgcctacaa tagccacgaa     1380

gagggcagac tggtgtacag atatggcggc gagcctgtgg gcagcttcgt tcagccttgt     1440

ctgaggcctc tgatgcccgc cattgctcac gccctgttca tggacatcac ccacgataac     1500

gagtgcccca tcgtgcacag aagcgcctac gacgctctgc ctagcaccac cattgtgtcc     1560

atggcctgtt gtgccagcgg cagcacaaga ggctatgacg aactggtgcc ccaccagatt     1620

tccgtggtgt ccgaggaacg gttctacacc aagtggaacc ccgaggctct gcccagcaat     1680

accggcgaag tgaatttcca gagcggcatc attgccgcca gatgcgccat cagcaagctg     1740

caccaagaac tgggcgccaa gggcttcatt caggtgtacg tggaccaggt cgacgaggac     1800

attgtggccg tgacaagaca cagccccagc atccatcaga gcgtggtggc tgtgaccaga     1860

accgccttca gaaaccccaa gaccagcttc tacagcaaag aggtgcccca gatgtgcatc     1920

cccggcaaga ttgaggaagt ggtgctcgag gcccggacca tcgagagaaa caccaagcct     1980

taccggaagg acgagaactc catcaacggc acccctgaca tcaccgtgga aatcagagag     2040

cacatccagc tcaacgagag caagatcgtg aaacaggccg gcgtggccac aaagggcccc     2100

aacgagtata tccaagagat tgagttcgag aatctgagcc ccggcagcgt gatcatcttc     2160

agagtgtccc tggatcctca cgctcaggtg gccgtgggca tcctgagaaa tcacctgaca     2220

cagttcagcc cacacttcaa gagcggaagc ctggccgtgg acaacgccga tcctatcctg     2280

aagatcccct tcgcctctct ggcctacaga ctgacactgg ctgagctgaa ccagatcctg     2340

tacagatgcg agtccgaaga gaaagaggat ggcggaggct gctacgacat ccccaattgg     2400

agcgccctga agtatgccgg actgcaggga ctgatgtctg tgctggccga gatcagaccc     2460

aagaacgacc tgggacaccc cttctgcaac aacctgagat ccggcgactg gatgatcgac     2520

tacgtgtcca acagactgat cagcagatcc ggcacaatcg ccgaagtcgg caaatggctg     2580

caggccatgt tcttctacct gaagcagatc cctcggtatc tgatcccctg ctacttcgac     2640

gccatcctga tcggcgccta caccacactg ctggataccg cctggaagca gatgtccagc     2700

ttcgtgcaga acggcagcac cttcgtgaag cacctgtctc tgggaagcgt gcagctgtgt     2760

ggcgtgggca aatttcccag cctgcctatc ctgtctcctg cactgatgga cgtgccctac     2820

cggctgaatg agatcaccaa agaaaaagag cagtgctgcg tcagcctggc tgctggcctg     2880

cctcattttt ccagcggcat cttccggtgt tggggcagag acacctttat tgccctgaga     2940

ggcatcctgc tgattaccgg cagatacgtg gaagcccgga acatcatcct ggcctttgcc     3000

ggcacactgc ggcacggact gattcctaat ctgctcggcg agggcatcta cgccagatac     3060

aactgcagag atgccgtgtg gtggtggctc cagtgcatcc aggactactg caagatggtg     3120

cccaacggcc tggacatcct gaagtgccct gtgtccagaa tgtaccctac cgacgatagc     3180

gcccctctgc ctgccggaac acttgaccag cctctgttcg aagtgattca agaggccatg     3240

cagaaacaca tgcagggaat ccagtttcgc gagcggaatg ccggacctca gatcgacaga     3300

aacatgaagg atgagggctt caacatcacc gctggcgtgg acgaagagac aggctttgtg     3360

tacggcggca accggttcaa ttgcggcacc tggatggaca agatgggcga gtctgaccgg     3420

gccagaaaca gaggaattcc cgccacacct agagatggca gcgctgtgga aatcgtgggc     3480

ctgtctaagt ctgctgtgcg gtggctgctc gaactgagca agaagaatat ctttccgtac     3540

cacgaagtga ccgtgaagcg gcacggcaag gccatcaagg tgtcctacga cgagtggaac     3600

agaaagatcc aggacaactt cgaaaagctg ttccatgtgt ctgaggaccc cagcgacctg     3660

aacgaaaagc accccaacct ggtgcacaag cgcggcatct acaaggacag ctacggcgcc     3720

tcttctcctt ggtgcgatta ccagctgcgg cccaacttca ccattgccat ggtggttgcc     3780

cctgagctgt tcaccacaga gaaggcctgg aaggccctgg aaatcgccga gaagaaactg     3840

ctgggccctc tgggcatgaa gacactggac cccgacgaca tggtgtactg cggaatctac     3900

gacaacgccc tggataacga caactacaat ctggccaagg ggttcaatta ccatcaggga     3960

cccgagtggc tgtggcctat cggctatttc ctgcgggcca agctgtactt ctccagactg     4020

atgggccctg agacaaccgc caagacaatc gtgctcgtga agaacgtgct gagccggcac     4080

tatgtgcacc tggaaagaag cccctggaag ggactgcccg agctgaccaa tgagaacgcc     4140

cagtactgcc ccttcagctg cgaaacacag gcctggtcta tcgccaccat cctggaaacc     4200

ctgtacgacc tgtga                                                      4215


<210>  58
<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  sNRP1 polyadenylation signal

<400>  58
aaataaaata cgaaatg                                                      17


<210>  59
<211>  4557
<212>  DNA
<213>  artificial

<220>
<223>  delta-9 GDE (isoform 1 (SEQ ID NO:1); wt version)

<400>  59
atggagaaac tggaaaagac cctcttcaga cttgaacaag ggtatgagct acagttccga       60

ttaggcccaa ctttacaggg aaaagcagtt accgtgtata caaattaccc atttcctgga      120

gaaacattta atagagaaaa attccgttct ctggattggg aaaatccaac agaaagagaa      180

gatgattctg ataaatactg taaacttaat ctgcaacaat ctggttcatt tcagtattat      240

ttccttcaag gaaatgagaa aagtggtgga ggttacatag ttgtggaccc cattttacgt      300

gttggtgctg ataatcatgt gctacccttg gactgtgtta ctcttcagac atttttagct      360

aagtgtttgg gaccttttga tgaatgggaa agcagactta gggttgcaaa agaatcaggc      420

tacaacatga ttcattttac cccattgcag actcttggac tatctaggtc atgctactcc      480

cttgccaatc agttagaatt aaatcctgac ttttcaagac ctaatagaaa gtatacctgg      540

aatgatgttg gacagctagt ggaaaaatta aaaaaggaat ggaatgttat ttgtattact      600

gatgttgtct acaatcatac tgctgctaat agtaaatgga tccaggaaca tccagaatgt      660

gcctataatc ttgtaaattc tccacactta aaacctgcct gggtcttaga cagagcactt      720

tggcgtttct cctgtgatgt tgcagaaggg aaatacaaag aaaagggaat acctgctttg      780

attgaaaatg atcaccatat gaactccatc cgaaaaataa tttgggagga tatttttcca      840

aagcttaaac tctgggaatt tttccaagta gatgtcaaca aagcggttga gcaatttaga      900

agacttctta cacaagaaaa taggcgagta accaagtctg atccaaacca acaccttacg      960

attattcaag atcctgaata cagacggttt ggctgtactg tagatatgaa cattgcacta     1020

acgactttca taccacatga caaggggcca gcagcaattg aagaatgctg taattggttt     1080

cataaaagaa tggaggaatt aaattcagag aagcatcgac tcattaacta tcatcaggaa     1140

caggcagtta attgcctttt gggaaatgtg ttttatgaac gactggctgg ccatggtcca     1200

aaactaggac ctgtcactag aaagcatcct ttagttacca ggtattttac tttcccattt     1260

gaagagatag acttctccat ggaagaatct atgattcatc tgccaaataa agcttgtttt     1320

ctgatggcac acaatggatg ggtaatggga gatgatcctc ttcgaaactt tgctgaaccg     1380

ggttcagaag tttacctaag gagagaactt atttgctggg gagacagtgt taaattacgc     1440

tatgggaata aaccagagga ctgtccttat ctctgggcac acatgaaaaa atacactgaa     1500

ataactgcaa cttatttcca gggagtacgt cttgataact gccactcaac acctcttcac     1560

gtagctgagt acatgttgga tgctgctagg aatttgcaac ccaatttata tgtagtagct     1620

gaactgttca caggaagtga ggacctagac aatgtctttg ttactagact gggcattagt     1680

tccttaataa gagaggcaat gagtgcatat aatagtcatg aagagggcag attagtttac     1740

cgatatggag gagaacctgt tggatccttt gttcagccct gtttgaggcc tttaatgcca     1800

gctattgcac atgccctgtt tatggatatt acgcatgata atgagtgtcc tattgtgcat     1860

agatcagcgt atgatgctct tccaagtact acaattgttt ctatggcatg ttgtgctagt     1920

ggaagtacaa gaggctatga tgaattagtg cctcatcaga tttcagtggt ttctgaagaa     1980

cggttttaca ctaagtggaa tcctgaagca ttgccttcaa acacaggtga agttaatttc     2040

caaagcggca ttattgcagc caggtgtgct atcagtaaac ttcatcagga gcttggagcc     2100

aagggtttta ttcaggtgta tgtggatcaa gttgatgaag acatagtggc agtaacaaga     2160

cactcaccta gcatccatca gtctgttgtg gctgtaacta gaactgcttt caggaatccc     2220

aagacttcat tttacagcaa ggaagtgcct caaatgtgca tccctggcaa aattgaagaa     2280

gtagttcttg aagctagaac tattgagaga aacacgaaac cttataggaa ggatgaaaat     2340

tcaatcaatg gaacaccaga tatcacagta gaaattagag aacatattca gcttaatgaa     2400

agtaaaattg ttaaacaagc tggagttgcc acaaaagggc ccaatgaata tattcaagaa     2460

atagaatttg aaaacttgtc tccaggaagt gttattatat tcagagttag tcttgatcca     2520

catgcacaag tcgctgttgg cattcttcga aatcatctga cacaattcag tcctcacttt     2580

aaatctggca gcctagctgt tgacaatgca gatcctatat taaaaattcc ttttgcttct     2640

cttgcctata gattaacttt ggctgagcta aatcagatcc tttaccgatg tgaatcagaa     2700

gaaaaggaag atggtggagg gtgctatgac ataccaaact ggtcagccct taaatatgca     2760

ggtcttcaag gtttaatgtc tgtattggca gaaataagac caaagaatga cttggggcat     2820

cctttttgta ataatttgag gtctggagat tggatgattg actatgtcag taaccggctt     2880

atttcacgat caggaactat tgctgaagtt ggtaaatggt tgcaggctat gttcttctac     2940

ctgaagcaga tcccacgtta ccttatccca tgttactttg atgctatatt aattggtgca     3000

tataccactc ttctggatac agcatggaag cagatgtcaa gctttgttca gaatggttca     3060

acctttgtga aacacctttc attgggttca gttcaactgt gtggagtagg aaaattccct     3120

tccctgccaa ttctttcacc tgccctaatg gatgtacctt ataggttaaa tgagatcaca     3180

aaagaaaagg agcaatgttg tgtttctcta gctgcaggct tacctcattt ttcttctggt     3240

attttccgct gctggggaag ggatactttt attgcactta gaggtatact gctgattact     3300

ggacgctatg tagaagccag gaatattatt ttagcatttg cgggtaccct gaggcatggt     3360

ctcattccta atctactggg tgaaggaatt tatgccagat acaattgtcg ggatgctgtg     3420

tggtggtggc tgcagtgtat ccaggattac tgtaaaatgg ttccaaatgg actagacatt     3480

ctcaagtgcc cagtttccag aatgtatcct acagatgatt ctgctccttt gcctgctggc     3540

acactggatc agccattgtt tgaagtcata caggaagcaa tgcaaaaaca catgcagggc     3600

atacagttcc gagaaaggaa tgctggtccc cagatagatc gaaacatgaa ggacgaaggt     3660

tttaatataa ctgcaggagt tgatgaagaa acaggatttg tttatggagg aaatcgtttc     3720

aattgtggca catggatgga taaaatggga gaaagtgaca gagctagaaa cagaggaatc     3780

ccagccacac caagagatgg gtctgctgtg gaaattgtgg gcctgagtaa atctgctgtt     3840

cgctggttgc tggaattatc caaaaaaaat attttccctt atcatgaagt cacagtaaaa     3900

agacatggaa aggctataaa ggtctcatat gatgagtgga acagaaaaat acaagacaac     3960

tttgaaaagc tatttcatgt ttccgaagac ccttcagatt taaatgaaaa gcatccaaat     4020

ctggttcaca aacgtggcat atacaaagat agttatggag cttcaagtcc ttggtgtgac     4080

tatcagctca ggcctaattt taccatagca atggttgtgg cccctgagct ctttactaca     4140

gaaaaagcat ggaaagcttt ggagattgca gaaaaaaaat tgcttggtcc ccttggcatg     4200

aaaactttag atccagatga tatggtttac tgtggaattt atgacaacgc attagacaat     4260

gacaactaca atcttgctaa aggtttcaat tatcaccaag gacctgagtg gctgtggcct     4320

attgggtatt ttcttcgtgc aaaattatat ttttccagat tgatgggccc ggagactact     4380

gcaaagacta tagttttggt taaaaatgtt ctttcccgac attatgttca tcttgagaga     4440

tccccttgga aaggacttcc agaactgacc aatgagaatg cccagtactg tcctttcagc     4500

tgtgaaacac aagcctggtc aattgctact attcttgaga cactttatga tttatag        4557


<210>  60
<211>  4512
<212>  DNA
<213>  artificial

<220>
<223>  delta-10 GDE (isoform 1 (SEQ ID NO:1); wt version)

<400>  60
atgctacagt tccgattagg cccaacttta cagggaaaag cagttaccgt gtatacaaat       60

tacccatttc ctggagaaac atttaataga gaaaaattcc gttctctgga ttgggaaaat      120

ccaacagaaa gagaagatga ttctgataaa tactgtaaac ttaatctgca acaatctggt      180

tcatttcagt attatttcct tcaaggaaat gagaaaagtg gtggaggtta catagttgtg      240

gaccccattt tacgtgttgg tgctgataat catgtgctac ccttggactg tgttactctt      300

cagacatttt tagctaagtg tttgggacct tttgatgaat gggaaagcag acttagggtt      360

gcaaaagaat caggctacaa catgattcat tttaccccat tgcagactct tggactatct      420

aggtcatgct actcccttgc caatcagtta gaattaaatc ctgacttttc aagacctaat      480

agaaagtata cctggaatga tgttggacag ctagtggaaa aattaaaaaa ggaatggaat      540

gttatttgta ttactgatgt tgtctacaat catactgctg ctaatagtaa atggatccag      600

gaacatccag aatgtgccta taatcttgta aattctccac acttaaaacc tgcctgggtc      660

ttagacagag cactttggcg tttctcctgt gatgttgcag aagggaaata caaagaaaag      720

ggaatacctg ctttgattga aaatgatcac catatgaact ccatccgaaa aataatttgg      780

gaggatattt ttccaaagct taaactctgg gaatttttcc aagtagatgt caacaaagcg      840

gttgagcaat ttagaagact tcttacacaa gaaaataggc gagtaaccaa gtctgatcca      900

aaccaacacc ttacgattat tcaagatcct gaatacagac ggtttggctg tactgtagat      960

atgaacattg cactaacgac tttcatacca catgacaagg ggccagcagc aattgaagaa     1020

tgctgtaatt ggtttcataa aagaatggag gaattaaatt cagagaagca tcgactcatt     1080

aactatcatc aggaacaggc agttaattgc cttttgggaa atgtgtttta tgaacgactg     1140

gctggccatg gtccaaaact aggacctgtc actagaaagc atcctttagt taccaggtat     1200

tttactttcc catttgaaga gatagacttc tccatggaag aatctatgat tcatctgcca     1260

aataaagctt gttttctgat ggcacacaat ggatgggtaa tgggagatga tcctcttcga     1320

aactttgctg aaccgggttc agaagtttac ctaaggagag aacttatttg ctggggagac     1380

agtgttaaat tacgctatgg gaataaacca gaggactgtc cttatctctg ggcacacatg     1440

aaaaaataca ctgaaataac tgcaacttat ttccagggag tacgtcttga taactgccac     1500

tcaacacctc ttcacgtagc tgagtacatg ttggatgctg ctaggaattt gcaacccaat     1560

ttatatgtag tagctgaact gttcacagga agtgaggacc tagacaatgt ctttgttact     1620

agactgggca ttagttcctt aataagagag gcaatgagtg catataatag tcatgaagag     1680

ggcagattag tttaccgata tggaggagaa cctgttggat cctttgttca gccctgtttg     1740

aggcctttaa tgccagctat tgcacatgcc ctgtttatgg atattacgca tgataatgag     1800

tgtcctattg tgcatagatc agcgtatgat gctcttccaa gtactacaat tgtttctatg     1860

gcatgttgtg ctagtggaag tacaagaggc tatgatgaat tagtgcctca tcagatttca     1920

gtggtttctg aagaacggtt ttacactaag tggaatcctg aagcattgcc ttcaaacaca     1980

ggtgaagtta atttccaaag cggcattatt gcagccaggt gtgctatcag taaacttcat     2040

caggagcttg gagccaaggg ttttattcag gtgtatgtgg atcaagttga tgaagacata     2100

gtggcagtaa caagacactc acctagcatc catcagtctg ttgtggctgt aactagaact     2160

gctttcagga atcccaagac ttcattttac agcaaggaag tgcctcaaat gtgcatccct     2220

ggcaaaattg aagaagtagt tcttgaagct agaactattg agagaaacac gaaaccttat     2280

aggaaggatg aaaattcaat caatggaaca ccagatatca cagtagaaat tagagaacat     2340

attcagctta atgaaagtaa aattgttaaa caagctggag ttgccacaaa agggcccaat     2400

gaatatattc aagaaataga atttgaaaac ttgtctccag gaagtgttat tatattcaga     2460

gttagtcttg atccacatgc acaagtcgct gttggcattc ttcgaaatca tctgacacaa     2520

ttcagtcctc actttaaatc tggcagccta gctgttgaca atgcagatcc tatattaaaa     2580

attccttttg cttctcttgc ctatagatta actttggctg agctaaatca gatcctttac     2640

cgatgtgaat cagaagaaaa ggaagatggt ggagggtgct atgacatacc aaactggtca     2700

gcccttaaat atgcaggtct tcaaggttta atgtctgtat tggcagaaat aagaccaaag     2760

aatgacttgg ggcatccttt ttgtaataat ttgaggtctg gagattggat gattgactat     2820

gtcagtaacc ggcttatttc acgatcagga actattgctg aagttggtaa atggttgcag     2880

gctatgttct tctacctgaa gcagatccca cgttacctta tcccatgtta ctttgatgct     2940

atattaattg gtgcatatac cactcttctg gatacagcat ggaagcagat gtcaagcttt     3000

gttcagaatg gttcaacctt tgtgaaacac ctttcattgg gttcagttca actgtgtgga     3060

gtaggaaaat tcccttccct gccaattctt tcacctgccc taatggatgt accttatagg     3120

ttaaatgaga tcacaaaaga aaaggagcaa tgttgtgttt ctctagctgc aggcttacct     3180

catttttctt ctggtatttt ccgctgctgg ggaagggata cttttattgc acttagaggt     3240

atactgctga ttactggacg ctatgtagaa gccaggaata ttattttagc atttgcgggt     3300

accctgaggc atggtctcat tcctaatcta ctgggtgaag gaatttatgc cagatacaat     3360

tgtcgggatg ctgtgtggtg gtggctgcag tgtatccagg attactgtaa aatggttcca     3420

aatggactag acattctcaa gtgcccagtt tccagaatgt atcctacaga tgattctgct     3480

cctttgcctg ctggcacact ggatcagcca ttgtttgaag tcatacagga agcaatgcaa     3540

aaacacatgc agggcataca gttccgagaa aggaatgctg gtccccagat agatcgaaac     3600

atgaaggacg aaggttttaa tataactgca ggagttgatg aagaaacagg atttgtttat     3660

ggaggaaatc gtttcaattg tggcacatgg atggataaaa tgggagaaag tgacagagct     3720

agaaacagag gaatcccagc cacaccaaga gatgggtctg ctgtggaaat tgtgggcctg     3780

agtaaatctg ctgttcgctg gttgctggaa ttatccaaaa aaaatatttt cccttatcat     3840

gaagtcacag taaaaagaca tggaaaggct ataaaggtct catatgatga gtggaacaga     3900

aaaatacaag acaactttga aaagctattt catgtttccg aagacccttc agatttaaat     3960

gaaaagcatc caaatctggt tcacaaacgt ggcatataca aagatagtta tggagcttca     4020

agtccttggt gtgactatca gctcaggcct aattttacca tagcaatggt tgtggcccct     4080

gagctcttta ctacagaaaa agcatggaaa gctttggaga ttgcagaaaa aaaattgctt     4140

ggtccccttg gcatgaaaac tttagatcca gatgatatgg tttactgtgg aatttatgac     4200

aacgcattag acaatgacaa ctacaatctt gctaaaggtt tcaattatca ccaaggacct     4260

gagtggctgt ggcctattgg gtattttctt cgtgcaaaat tatatttttc cagattgatg     4320

ggcccggaga ctactgcaaa gactatagtt ttggttaaaa atgttctttc ccgacattat     4380

gttcatcttg agagatcccc ttggaaagga cttccagaac tgaccaatga gaatgcccag     4440

tactgtcctt tcagctgtga aacacaagcc tggtcaattg ctactattct tgagacactt     4500

tatgatttat ag                                                         4512


<210>  61
<211>  4359
<212>  DNA
<213>  artificial

<220>
<223>  delta-11 GDE (isoform 1 (SEQ ID NO:1); wt version)

<400>  61
atgaaactta atctgcaaca atctggttca tttcagtatt atttccttca aggaaatgag       60

aaaagtggtg gaggttacat agttgtggac cccattttac gtgttggtgc tgataatcat      120

gtgctaccct tggactgtgt tactcttcag acatttttag ctaagtgttt gggacctttt      180

gatgaatggg aaagcagact tagggttgca aaagaatcag gctacaacat gattcatttt      240

accccattgc agactcttgg actatctagg tcatgctact cccttgccaa tcagttagaa      300

ttaaatcctg acttttcaag acctaataga aagtatacct ggaatgatgt tggacagcta      360

gtggaaaaat taaaaaagga atggaatgtt atttgtatta ctgatgttgt ctacaatcat      420

actgctgcta atagtaaatg gatccaggaa catccagaat gtgcctataa tcttgtaaat      480

tctccacact taaaacctgc ctgggtctta gacagagcac tttggcgttt ctcctgtgat      540

gttgcagaag ggaaatacaa agaaaaggga atacctgctt tgattgaaaa tgatcaccat      600

atgaactcca tccgaaaaat aatttgggag gatatttttc caaagcttaa actctgggaa      660

tttttccaag tagatgtcaa caaagcggtt gagcaattta gaagacttct tacacaagaa      720

aataggcgag taaccaagtc tgatccaaac caacacctta cgattattca agatcctgaa      780

tacagacggt ttggctgtac tgtagatatg aacattgcac taacgacttt cataccacat      840

gacaaggggc cagcagcaat tgaagaatgc tgtaattggt ttcataaaag aatggaggaa      900

ttaaattcag agaagcatcg actcattaac tatcatcagg aacaggcagt taattgcctt      960

ttgggaaatg tgttttatga acgactggct ggccatggtc caaaactagg acctgtcact     1020

agaaagcatc ctttagttac caggtatttt actttcccat ttgaagagat agacttctcc     1080

atggaagaat ctatgattca tctgccaaat aaagcttgtt ttctgatggc acacaatgga     1140

tgggtaatgg gagatgatcc tcttcgaaac tttgctgaac cgggttcaga agtttaccta     1200

aggagagaac ttatttgctg gggagacagt gttaaattac gctatgggaa taaaccagag     1260

gactgtcctt atctctgggc acacatgaaa aaatacactg aaataactgc aacttatttc     1320

cagggagtac gtcttgataa ctgccactca acacctcttc acgtagctga gtacatgttg     1380

gatgctgcta ggaatttgca acccaattta tatgtagtag ctgaactgtt cacaggaagt     1440

gaggacctag acaatgtctt tgttactaga ctgggcatta gttccttaat aagagaggca     1500

atgagtgcat ataatagtca tgaagagggc agattagttt accgatatgg aggagaacct     1560

gttggatcct ttgttcagcc ctgtttgagg cctttaatgc cagctattgc acatgccctg     1620

tttatggata ttacgcatga taatgagtgt cctattgtgc atagatcagc gtatgatgct     1680

cttccaagta ctacaattgt ttctatggca tgttgtgcta gtggaagtac aagaggctat     1740

gatgaattag tgcctcatca gatttcagtg gtttctgaag aacggtttta cactaagtgg     1800

aatcctgaag cattgccttc aaacacaggt gaagttaatt tccaaagcgg cattattgca     1860

gccaggtgtg ctatcagtaa acttcatcag gagcttggag ccaagggttt tattcaggtg     1920

tatgtggatc aagttgatga agacatagtg gcagtaacaa gacactcacc tagcatccat     1980

cagtctgttg tggctgtaac tagaactgct ttcaggaatc ccaagacttc attttacagc     2040

aaggaagtgc ctcaaatgtg catccctggc aaaattgaag aagtagttct tgaagctaga     2100

actattgaga gaaacacgaa accttatagg aaggatgaaa attcaatcaa tggaacacca     2160

gatatcacag tagaaattag agaacatatt cagcttaatg aaagtaaaat tgttaaacaa     2220

gctggagttg ccacaaaagg gcccaatgaa tatattcaag aaatagaatt tgaaaacttg     2280

tctccaggaa gtgttattat attcagagtt agtcttgatc cacatgcaca agtcgctgtt     2340

ggcattcttc gaaatcatct gacacaattc agtcctcact ttaaatctgg cagcctagct     2400

gttgacaatg cagatcctat attaaaaatt ccttttgctt ctcttgccta tagattaact     2460

ttggctgagc taaatcagat cctttaccga tgtgaatcag aagaaaagga agatggtgga     2520

gggtgctatg acataccaaa ctggtcagcc cttaaatatg caggtcttca aggtttaatg     2580

tctgtattgg cagaaataag accaaagaat gacttggggc atcctttttg taataatttg     2640

aggtctggag attggatgat tgactatgtc agtaaccggc ttatttcacg atcaggaact     2700

attgctgaag ttggtaaatg gttgcaggct atgttcttct acctgaagca gatcccacgt     2760

taccttatcc catgttactt tgatgctata ttaattggtg catataccac tcttctggat     2820

acagcatgga agcagatgtc aagctttgtt cagaatggtt caacctttgt gaaacacctt     2880

tcattgggtt cagttcaact gtgtggagta ggaaaattcc cttccctgcc aattctttca     2940

cctgccctaa tggatgtacc ttataggtta aatgagatca caaaagaaaa ggagcaatgt     3000

tgtgtttctc tagctgcagg cttacctcat ttttcttctg gtattttccg ctgctgggga     3060

agggatactt ttattgcact tagaggtata ctgctgatta ctggacgcta tgtagaagcc     3120

aggaatatta ttttagcatt tgcgggtacc ctgaggcatg gtctcattcc taatctactg     3180

ggtgaaggaa tttatgccag atacaattgt cgggatgctg tgtggtggtg gctgcagtgt     3240

atccaggatt actgtaaaat ggttccaaat ggactagaca ttctcaagtg cccagtttcc     3300

agaatgtatc ctacagatga ttctgctcct ttgcctgctg gcacactgga tcagccattg     3360

tttgaagtca tacaggaagc aatgcaaaaa cacatgcagg gcatacagtt ccgagaaagg     3420

aatgctggtc cccagataga tcgaaacatg aaggacgaag gttttaatat aactgcagga     3480

gttgatgaag aaacaggatt tgtttatgga ggaaatcgtt tcaattgtgg cacatggatg     3540

gataaaatgg gagaaagtga cagagctaga aacagaggaa tcccagccac accaagagat     3600

gggtctgctg tggaaattgt gggcctgagt aaatctgctg ttcgctggtt gctggaatta     3660

tccaaaaaaa atattttccc ttatcatgaa gtcacagtaa aaagacatgg aaaggctata     3720

aaggtctcat atgatgagtg gaacagaaaa atacaagaca actttgaaaa gctatttcat     3780

gtttccgaag acccttcaga tttaaatgaa aagcatccaa atctggttca caaacgtggc     3840

atatacaaag atagttatgg agcttcaagt ccttggtgtg actatcagct caggcctaat     3900

tttaccatag caatggttgt ggcccctgag ctctttacta cagaaaaagc atggaaagct     3960

ttggagattg cagaaaaaaa attgcttggt ccccttggca tgaaaacttt agatccagat     4020

gatatggttt actgtggaat ttatgacaac gcattagaca atgacaacta caatcttgct     4080

aaaggtttca attatcacca aggacctgag tggctgtggc ctattgggta ttttcttcgt     4140

gcaaaattat atttttccag attgatgggc ccggagacta ctgcaaagac tatagttttg     4200

gttaaaaatg ttctttcccg acattatgtt catcttgaga gatccccttg gaaaggactt     4260

ccagaactga ccaatgagaa tgcccagtac tgtcctttca gctgtgaaac acaagcctgg     4320

tcaattgcta ctattcttga gacactttat gatttatag                            4359


<210>  62
<211>  4293
<212>  DNA
<213>  artificial

<220>
<223>  delta-12 GDE (isoform 1 (SEQ ID NO:1); wt version)

<400>  62
atgggaggtt acatagttgt ggaccccatt ttacgtgttg gtgctgataa tcatgtgcta       60

cccttggact gtgttactct tcagacattt ttagctaagt gtttgggacc ttttgatgaa      120

tgggaaagca gacttagggt tgcaaaagaa tcaggctaca acatgattca ttttacccca      180

ttgcagactc ttggactatc taggtcatgc tactcccttg ccaatcagtt agaattaaat      240

cctgactttt caagacctaa tagaaagtat acctggaatg atgttggaca gctagtggaa      300

aaattaaaaa aggaatggaa tgttatttgt attactgatg ttgtctacaa tcatactgct      360

gctaatagta aatggatcca ggaacatcca gaatgtgcct ataatcttgt aaattctcca      420

cacttaaaac ctgcctgggt cttagacaga gcactttggc gtttctcctg tgatgttgca      480

gaagggaaat acaaagaaaa gggaatacct gctttgattg aaaatgatca ccatatgaac      540

tccatccgaa aaataatttg ggaggatatt tttccaaagc ttaaactctg ggaatttttc      600

caagtagatg tcaacaaagc ggttgagcaa tttagaagac ttcttacaca agaaaatagg      660

cgagtaacca agtctgatcc aaaccaacac cttacgatta ttcaagatcc tgaatacaga      720

cggtttggct gtactgtaga tatgaacatt gcactaacga ctttcatacc acatgacaag      780

gggccagcag caattgaaga atgctgtaat tggtttcata aaagaatgga ggaattaaat      840

tcagagaagc atcgactcat taactatcat caggaacagg cagttaattg ccttttggga      900

aatgtgtttt atgaacgact ggctggccat ggtccaaaac taggacctgt cactagaaag      960

catcctttag ttaccaggta ttttactttc ccatttgaag agatagactt ctccatggaa     1020

gaatctatga ttcatctgcc aaataaagct tgttttctga tggcacacaa tggatgggta     1080

atgggagatg atcctcttcg aaactttgct gaaccgggtt cagaagttta cctaaggaga     1140

gaacttattt gctggggaga cagtgttaaa ttacgctatg ggaataaacc agaggactgt     1200

ccttatctct gggcacacat gaaaaaatac actgaaataa ctgcaactta tttccaggga     1260

gtacgtcttg ataactgcca ctcaacacct cttcacgtag ctgagtacat gttggatgct     1320

gctaggaatt tgcaacccaa tttatatgta gtagctgaac tgttcacagg aagtgaggac     1380

ctagacaatg tctttgttac tagactgggc attagttcct taataagaga ggcaatgagt     1440

gcatataata gtcatgaaga gggcagatta gtttaccgat atggaggaga acctgttgga     1500

tcctttgttc agccctgttt gaggccttta atgccagcta ttgcacatgc cctgtttatg     1560

gatattacgc atgataatga gtgtcctatt gtgcatagat cagcgtatga tgctcttcca     1620

agtactacaa ttgtttctat ggcatgttgt gctagtggaa gtacaagagg ctatgatgaa     1680

ttagtgcctc atcagatttc agtggtttct gaagaacggt tttacactaa gtggaatcct     1740

gaagcattgc cttcaaacac aggtgaagtt aatttccaaa gcggcattat tgcagccagg     1800

tgtgctatca gtaaacttca tcaggagctt ggagccaagg gttttattca ggtgtatgtg     1860

gatcaagttg atgaagacat agtggcagta acaagacact cacctagcat ccatcagtct     1920

gttgtggctg taactagaac tgctttcagg aatcccaaga cttcatttta cagcaaggaa     1980

gtgcctcaaa tgtgcatccc tggcaaaatt gaagaagtag ttcttgaagc tagaactatt     2040

gagagaaaca cgaaacctta taggaaggat gaaaattcaa tcaatggaac accagatatc     2100

acagtagaaa ttagagaaca tattcagctt aatgaaagta aaattgttaa acaagctgga     2160

gttgccacaa aagggcccaa tgaatatatt caagaaatag aatttgaaaa cttgtctcca     2220

ggaagtgtta ttatattcag agttagtctt gatccacatg cacaagtcgc tgttggcatt     2280

cttcgaaatc atctgacaca attcagtcct cactttaaat ctggcagcct agctgttgac     2340

aatgcagatc ctatattaaa aattcctttt gcttctcttg cctatagatt aactttggct     2400

gagctaaatc agatccttta ccgatgtgaa tcagaagaaa aggaagatgg tggagggtgc     2460

tatgacatac caaactggtc agcccttaaa tatgcaggtc ttcaaggttt aatgtctgta     2520

ttggcagaaa taagaccaaa gaatgacttg gggcatcctt tttgtaataa tttgaggtct     2580

ggagattgga tgattgacta tgtcagtaac cggcttattt cacgatcagg aactattgct     2640

gaagttggta aatggttgca ggctatgttc ttctacctga agcagatccc acgttacctt     2700

atcccatgtt actttgatgc tatattaatt ggtgcatata ccactcttct ggatacagca     2760

tggaagcaga tgtcaagctt tgttcagaat ggttcaacct ttgtgaaaca cctttcattg     2820

ggttcagttc aactgtgtgg agtaggaaaa ttcccttccc tgccaattct ttcacctgcc     2880

ctaatggatg taccttatag gttaaatgag atcacaaaag aaaaggagca atgttgtgtt     2940

tctctagctg caggcttacc tcatttttct tctggtattt tccgctgctg gggaagggat     3000

acttttattg cacttagagg tatactgctg attactggac gctatgtaga agccaggaat     3060

attattttag catttgcggg taccctgagg catggtctca ttcctaatct actgggtgaa     3120

ggaatttatg ccagatacaa ttgtcgggat gctgtgtggt ggtggctgca gtgtatccag     3180

gattactgta aaatggttcc aaatggacta gacattctca agtgcccagt ttccagaatg     3240

tatcctacag atgattctgc tcctttgcct gctggcacac tggatcagcc attgtttgaa     3300

gtcatacagg aagcaatgca aaaacacatg cagggcatac agttccgaga aaggaatgct     3360

ggtccccaga tagatcgaaa catgaaggac gaaggtttta atataactgc aggagttgat     3420

gaagaaacag gatttgttta tggaggaaat cgtttcaatt gtggcacatg gatggataaa     3480

atgggagaaa gtgacagagc tagaaacaga ggaatcccag ccacaccaag agatgggtct     3540

gctgtggaaa ttgtgggcct gagtaaatct gctgttcgct ggttgctgga attatccaaa     3600

aaaaatattt tcccttatca tgaagtcaca gtaaaaagac atggaaaggc tataaaggtc     3660

tcatatgatg agtggaacag aaaaatacaa gacaactttg aaaagctatt tcatgtttcc     3720

gaagaccctt cagatttaaa tgaaaagcat ccaaatctgg ttcacaaacg tggcatatac     3780

aaagatagtt atggagcttc aagtccttgg tgtgactatc agctcaggcc taattttacc     3840

atagcaatgg ttgtggcccc tgagctcttt actacagaaa aagcatggaa agctttggag     3900

attgcagaaa aaaaattgct tggtcccctt ggcatgaaaa ctttagatcc agatgatatg     3960

gtttactgtg gaatttatga caacgcatta gacaatgaca actacaatct tgctaaaggt     4020

ttcaattatc accaaggacc tgagtggctg tggcctattg ggtattttct tcgtgcaaaa     4080

ttatattttt ccagattgat gggcccggag actactgcaa agactatagt tttggttaaa     4140

aatgttcttt cccgacatta tgttcatctt gagagatccc cttggaaagg acttccagaa     4200

ctgaccaatg agaatgccca gtactgtcct ttcagctgtg aaacacaagc ctggtcaatt     4260

gctactattc ttgagacact ttatgattta tag                                  4293


<210>  63
<211>  4215
<212>  DNA
<213>  artificial

<220>
<223>  delta-13 GDE (isoform 1 (SEQ ID NO:1); wt version)

<400>  63
atgcagacat ttttagctaa gtgtttggga ccttttgatg aatgggaaag cagacttagg       60

gttgcaaaag aatcaggcta caacatgatt cattttaccc cattgcagac tcttggacta      120

tctaggtcat gctactccct tgccaatcag ttagaattaa atcctgactt ttcaagacct      180

aatagaaagt atacctggaa tgatgttgga cagctagtgg aaaaattaaa aaaggaatgg      240

aatgttattt gtattactga tgttgtctac aatcatactg ctgctaatag taaatggatc      300

caggaacatc cagaatgtgc ctataatctt gtaaattctc cacacttaaa acctgcctgg      360

gtcttagaca gagcactttg gcgtttctcc tgtgatgttg cagaagggaa atacaaagaa      420

aagggaatac ctgctttgat tgaaaatgat caccatatga actccatccg aaaaataatt      480

tgggaggata tttttccaaa gcttaaactc tgggaatttt tccaagtaga tgtcaacaaa      540

gcggttgagc aatttagaag acttcttaca caagaaaata ggcgagtaac caagtctgat      600

ccaaaccaac accttacgat tattcaagat cctgaataca gacggtttgg ctgtactgta      660

gatatgaaca ttgcactaac gactttcata ccacatgaca aggggccagc agcaattgaa      720

gaatgctgta attggtttca taaaagaatg gaggaattaa attcagagaa gcatcgactc      780

attaactatc atcaggaaca ggcagttaat tgccttttgg gaaatgtgtt ttatgaacga      840

ctggctggcc atggtccaaa actaggacct gtcactagaa agcatccttt agttaccagg      900

tattttactt tcccatttga agagatagac ttctccatgg aagaatctat gattcatctg      960

ccaaataaag cttgttttct gatggcacac aatggatggg taatgggaga tgatcctctt     1020

cgaaactttg ctgaaccggg ttcagaagtt tacctaagga gagaacttat ttgctgggga     1080

gacagtgtta aattacgcta tgggaataaa ccagaggact gtccttatct ctgggcacac     1140

atgaaaaaat acactgaaat aactgcaact tatttccagg gagtacgtct tgataactgc     1200

cactcaacac ctcttcacgt agctgagtac atgttggatg ctgctaggaa tttgcaaccc     1260

aatttatatg tagtagctga actgttcaca ggaagtgagg acctagacaa tgtctttgtt     1320

actagactgg gcattagttc cttaataaga gaggcaatga gtgcatataa tagtcatgaa     1380

gagggcagat tagtttaccg atatggagga gaacctgttg gatcctttgt tcagccctgt     1440

ttgaggcctt taatgccagc tattgcacat gccctgttta tggatattac gcatgataat     1500

gagtgtccta ttgtgcatag atcagcgtat gatgctcttc caagtactac aattgtttct     1560

atggcatgtt gtgctagtgg aagtacaaga ggctatgatg aattagtgcc tcatcagatt     1620

tcagtggttt ctgaagaacg gttttacact aagtggaatc ctgaagcatt gccttcaaac     1680

acaggtgaag ttaatttcca aagcggcatt attgcagcca ggtgtgctat cagtaaactt     1740

catcaggagc ttggagccaa gggttttatt caggtgtatg tggatcaagt tgatgaagac     1800

atagtggcag taacaagaca ctcacctagc atccatcagt ctgttgtggc tgtaactaga     1860

actgctttca ggaatcccaa gacttcattt tacagcaagg aagtgcctca aatgtgcatc     1920

cctggcaaaa ttgaagaagt agttcttgaa gctagaacta ttgagagaaa cacgaaacct     1980

tataggaagg atgaaaattc aatcaatgga acaccagata tcacagtaga aattagagaa     2040

catattcagc ttaatgaaag taaaattgtt aaacaagctg gagttgccac aaaagggccc     2100

aatgaatata ttcaagaaat agaatttgaa aacttgtctc caggaagtgt tattatattc     2160

agagttagtc ttgatccaca tgcacaagtc gctgttggca ttcttcgaaa tcatctgaca     2220

caattcagtc ctcactttaa atctggcagc ctagctgttg acaatgcaga tcctatatta     2280

aaaattcctt ttgcttctct tgcctataga ttaactttgg ctgagctaaa tcagatcctt     2340

taccgatgtg aatcagaaga aaaggaagat ggtggagggt gctatgacat accaaactgg     2400

tcagccctta aatatgcagg tcttcaaggt ttaatgtctg tattggcaga aataagacca     2460

aagaatgact tggggcatcc tttttgtaat aatttgaggt ctggagattg gatgattgac     2520

tatgtcagta accggcttat ttcacgatca ggaactattg ctgaagttgg taaatggttg     2580

caggctatgt tcttctacct gaagcagatc ccacgttacc ttatcccatg ttactttgat     2640

gctatattaa ttggtgcata taccactctt ctggatacag catggaagca gatgtcaagc     2700

tttgttcaga atggttcaac ctttgtgaaa cacctttcat tgggttcagt tcaactgtgt     2760

ggagtaggaa aattcccttc cctgccaatt ctttcacctg ccctaatgga tgtaccttat     2820

aggttaaatg agatcacaaa agaaaaggag caatgttgtg tttctctagc tgcaggctta     2880

cctcattttt cttctggtat tttccgctgc tggggaaggg atacttttat tgcacttaga     2940

ggtatactgc tgattactgg acgctatgta gaagccagga atattatttt agcatttgcg     3000

ggtaccctga ggcatggtct cattcctaat ctactgggtg aaggaattta tgccagatac     3060

aattgtcggg atgctgtgtg gtggtggctg cagtgtatcc aggattactg taaaatggtt     3120

ccaaatggac tagacattct caagtgccca gtttccagaa tgtatcctac agatgattct     3180

gctcctttgc ctgctggcac actggatcag ccattgtttg aagtcataca ggaagcaatg     3240

caaaaacaca tgcagggcat acagttccga gaaaggaatg ctggtcccca gatagatcga     3300

aacatgaagg acgaaggttt taatataact gcaggagttg atgaagaaac aggatttgtt     3360

tatggaggaa atcgtttcaa ttgtggcaca tggatggata aaatgggaga aagtgacaga     3420

gctagaaaca gaggaatccc agccacacca agagatgggt ctgctgtgga aattgtgggc     3480

ctgagtaaat ctgctgttcg ctggttgctg gaattatcca aaaaaaatat tttcccttat     3540

catgaagtca cagtaaaaag acatggaaag gctataaagg tctcatatga tgagtggaac     3600

agaaaaatac aagacaactt tgaaaagcta tttcatgttt ccgaagaccc ttcagattta     3660

aatgaaaagc atccaaatct ggttcacaaa cgtggcatat acaaagatag ttatggagct     3720

tcaagtcctt ggtgtgacta tcagctcagg cctaatttta ccatagcaat ggttgtggcc     3780

cctgagctct ttactacaga aaaagcatgg aaagctttgg agattgcaga aaaaaaattg     3840

cttggtcccc ttggcatgaa aactttagat ccagatgata tggtttactg tggaatttat     3900

gacaacgcat tagacaatga caactacaat cttgctaaag gtttcaatta tcaccaagga     3960

cctgagtggc tgtggcctat tgggtatttt cttcgtgcaa aattatattt ttccagattg     4020

atgggcccgg agactactgc aaagactata gttttggtta aaaatgttct ttcccgacat     4080

tatgttcatc ttgagagatc cccttggaaa ggacttccag aactgaccaa tgagaatgcc     4140

cagtactgtc ctttcagctg tgaaacacaa gcctggtcaa ttgctactat tcttgagaca     4200

ctttatgatt tatag                                                      4215


