                         SEQUENCE LISTING

<110>  ETH Zuerich
 
<120>  POLYPEPTIDES SELF-ASSEMBLING INTO NANOPARTICLES

<130>  P5542PC00

<150>  EP18187862
<151>  2018-08-07

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  At least 3 of the X amino acids at positions 11, 39, 66, 103,, 
       130, and 163  are independently of each other a positively 
       charged amino acid.

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  At least 3 of the X amino acids at positions 11, 39, 66, 103,, 
       130, and 163  are independently of each other a positively 
       charged amino acid.

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  At least 3 of the X amino acids at positions 11, 39, 66, 103,, 
       130, and 163  are independently of each other a positively 
       charged amino acid.

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (90)..(90)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  At least 3 of the X amino acids at positions 11, 39, 66, 103,, 
       130, and 163  are independently of each other a positively 
       charged amino acid.

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (120)..(120)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (130)..(130)
<223>  At least 3 of the X amino acids at positions 11, 39, 66, 103,, 
       130, and 163  are independently of each other a positively 
       charged amino acid.

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  At least 3 of the X amino acids at positions 11, 39, 66, 103,, 
       130, and 163  are independently of each other a positively 
       charged amino acid.

<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (175)..(175)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (183)..(183)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (185)..(185)
<223>  Any amino acid

<400>  1

Met Xaa Gln Ala Ile Gly Ile Leu Glu Leu Xaa Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Xaa Val Xaa Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Xaa Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Xaa Ala Ile Xaa Xaa Ala Ile Xaa Thr Gly Thr Xaa Gln Ala 
    50                  55                  60                  


Gly Xaa Leu Leu Val Asp Ser Leu Val Leu Ala Xaa Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Xaa Gly Xaa Asn Xaa Val Xaa Xaa Xaa Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Xaa Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Xaa Ala Val Xaa Gly Ser Xaa Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Xaa Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Xaa Leu Val Tyr Ala Ser Leu Ile Pro Xaa Pro His Xaa Ala 
                165                 170                 175     


Met Trp Xaa Gln Met Val Xaa Gly Xaa Glu 
            180                 185     


<210>  2
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  2

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  3
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  3

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu Gly Ser 
            180                 185             


<210>  4
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  4

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Cys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  5
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  5

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Cys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


Glu Phe Pro Pro Glu Val Glu Glu Gln Asp Asp Gly Thr Leu Pro Met 
        195                 200                 205             


Ser Cys Ala Gln Glu Ser Gly Met Asp Arg His Pro Ala Ala Cys Ala 
    210                 215                 220                 


Ser Ala Arg Ile Asn Val 
225                 230 


<210>  6
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  6

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Thr Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Trp Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Phe Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Leu Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  7
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  7

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Thr Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Trp Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Leu Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  8
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  8

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Pro Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Phe Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Leu Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  9
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  9

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Trp Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Phe Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Leu Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  10
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  10

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Thr Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Pro Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  11
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  11

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Trp Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Leu Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His 
            180                 185                 190     


<210>  12
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  12

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Leu Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  13
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  13

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Pro Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Phe Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  14
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  14

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Pro Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  15
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  15

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Trp Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  16
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  16

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Leu Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  17
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  17

Glu Phe Pro Pro Glu Val Glu Glu Gln Asp Asp Gly Thr Leu Pro Met 
1               5                   10                  15      


Ser Cys Ala Gln Glu Ser Gly Met Asp Arg His Pro Ala Ala Cys Ala 
            20                  25                  30          


Ser Ala Arg Ile Asn Val 
        35              


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  18
ttaattaaag acttcaagcg g                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  19
gcttgaagtc tttaattaat t                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  20
gaacttcagg gtcagcttgg g                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  21
caagctgacc ctgaagttct t                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  22
gaacttcagg gtcagcttgg g                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  23
caagctgacc ctgaagttct t                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  24
uaaggcuaug aagagauact t                                                 21


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  25
guaucuuuca uagccuuatt                                                   20


<210>  26
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  26
tcgagggcag ctaatgag                                                     18


<210>  27
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  27
tgcactcatt agctgccc                                                     18


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  28
cgtggcgagc agcagcgc                                                     18


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  29
cctggtgcgt gtgcacatgg                                                   20


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  30
gtgctcgaga ccttccacca tc                                                22


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  31
ggtgatgcga tgctgaaaag cgc                                               23


<210>  32
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  32
gcgattcagc aggcgattga aacc                                              24


<210>  33
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  33
cgattagcgg tctgaatagc gtgg                                              24


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  34
ggtttcaatc gcctgctgaa tcgc                                              24


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  35
ccacgctatt cagaccgcta atcg                                              24


<210>  36
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  36
gaaggagata tacatatgag ccaggc                                            26


<210>  37
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  37

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His 
            180                 185                 


<210>  38
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  38

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


His His His 
        195 


