                         SEQUENCE LISTING

<110>  Medigene Immunotherapies GmbH
 
<120>  HA-1 specific T cell receptors and their use

<130>  M11350WO

<150>  EP18187539.4
<151>  2018-08-06

<160>  127   

<170>  PatentIn version 3.5

<210>  1
<211>  1136
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Phe Ser Arg Lys Lys Arg Glu Leu Met Lys Thr Pro Ser Ile Ser 
1               5                   10                  15      


Lys Lys Asn Arg Ala Gly Ser Pro Ser Pro Gln Pro Ser Gly Glu Leu 
            20                  25                  30          


Pro Arg Lys Asp Gly Ala Asp Ala Val Phe Pro Gly Pro Ser Leu Glu 
        35                  40                  45              


Pro Pro Ala Gly Ser Ser Gly Val Lys Ala Thr Gly Thr Leu Lys Arg 
    50                  55                  60                  


Pro Thr Ser Leu Ser Arg His Ala Ser Ala Ala Gly Phe Pro Leu Ser 
65                  70                  75                  80  


Gly Ala Ala Ser Trp Thr Leu Gly Arg Ser His Arg Ser Pro Leu Thr 
                85                  90                  95      


Ala Ala Ser Pro Gly Glu Leu Pro Thr Glu Gly Ala Gly Pro Asp Val 
            100                 105                 110         


Val Glu Asp Ile Ser His Leu Leu Ala Asp Val Ala Arg Phe Ala Glu 
        115                 120                 125             


Gly Leu Glu Lys Leu Lys Glu Cys Val Leu His Asp Asp Leu Leu Glu 
    130                 135                 140                 


Ala Arg Arg Pro Arg Ala His Glu Cys Leu Gly Glu Ala Leu Arg Val 
145                 150                 155                 160 


Met His Gln Ile Ile Ser Lys Tyr Pro Leu Leu Asn Thr Val Glu Thr 
                165                 170                 175     


Leu Thr Ala Ala Gly Thr Leu Ile Ala Lys Val Lys Ala Phe His Tyr 
            180                 185                 190         


Glu Ser Asn Asn Asp Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu Glu 
        195                 200                 205             


Thr Ile Ala Val Ala Phe Ser Ser Thr Val Ser Glu Phe Leu Met Gly 
    210                 215                 220                 


Glu Val Asp Ser Ser Thr Leu Leu Ala Val Pro Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Gln Ser Met Glu Ser Leu Tyr Gly Pro Gly Ser Glu Gly Thr Pro Pro 
                245                 250                 255     


Ser Leu Glu Asp Cys Asp Ala Gly Cys Leu Pro Ala Glu Glu Val Asp 
            260                 265                 270         


Val Leu Leu Gln Arg Cys Glu Gly Gly Val Asp Ala Ala Leu Leu Tyr 
        275                 280                 285             


Ala Lys Asn Met Ala Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu Glu 
    290                 295                 300                 


Lys Arg Thr Thr Leu Glu Met Glu Phe Ala Lys Gly Leu Gln Lys Ile 
305                 310                 315                 320 


Ala His Asn Cys Arg Gln Ser Val Met Gln Glu Pro His Met Pro Leu 
                325                 330                 335     


Leu Ser Ile Tyr Ser Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly His 
            340                 345                 350         


Ser Met Val Gln Ala Val Gly Thr Leu Gln Thr Gln Thr Phe Met Gln 
        355                 360                 365             


Pro Leu Thr Leu Arg Arg Leu Glu His Glu Lys Arg Arg Lys Glu Ile 
    370                 375                 380                 


Lys Glu Ala Trp His Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu Ser 
385                 390                 395                 400 


Asn Leu Arg Lys Ala Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp His 
                405                 410                 415     


Asp Lys Ala Arg Phe Leu Val Ala Lys Ala Glu Glu Glu Gln Ala Gly 
            420                 425                 430         


Ser Ala Pro Gly Ala Gly Ser Thr Ala Thr Lys Thr Leu Asp Lys Arg 
        435                 440                 445             


Arg Arg Leu Glu Glu Glu Ala Lys Asn Lys Ala Glu Glu Ala Met Ala 
    450                 455                 460                 


Thr Tyr Arg Thr Cys Val Ala Asp Ala Lys Thr Gln Lys Gln Glu Leu 
465                 470                 475                 480 


Glu Asp Thr Lys Val Thr Ala Leu Arg Gln Ile Gln Glu Val Ile Arg 
                485                 490                 495     


Gln Ser Asp Gln Thr Ile Lys Ser Ala Thr Ile Ser Tyr Tyr Gln Met 
            500                 505                 510         


Met His Met Gln Thr Ala Pro Leu Pro Val His Phe Gln Met Leu Cys 
        515                 520                 525             


Glu Ser Ser Lys Leu Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His Val 
    530                 535                 540                 


Arg Gln Leu Gln Arg Asp Gln Glu Pro Asp Val His Tyr Asp Phe Glu 
545                 550                 555                 560 


Pro His Val Ser Ala Asn Ala Trp Ser Pro Val Met Arg Ala Arg Lys 
                565                 570                 575     


Ser Ser Phe Asn Val Ser Asp Val Ala Arg Pro Glu Ala Ala Gly Ser 
            580                 585                 590         


Pro Pro Glu Glu Gly Gly Cys Thr Glu Gly Thr Pro Ala Lys Asp His 
        595                 600                 605             


Arg Ala Gly Arg Gly His Gln Val His Lys Ser Trp Pro Leu Ser Ile 
    610                 615                 620                 


Ser Asp Ser Asp Ser Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Glu Arg Thr Ser Ser Ser Gly Thr Met Ser Ser Thr Glu 
                645                 650                 655     


Glu Leu Val Asp Pro Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu Gln 
            660                 665                 670         


Ala Asp Leu Asn Gly Met Thr Pro Glu Leu Pro Val Ala Val Pro Ser 
        675                 680                 685             


Gly Pro Phe Arg His Glu Gly Leu Ser Lys Ala Ala Arg Thr His Arg 
    690                 695                 700                 


Leu Arg Lys Leu Arg Thr Pro Ala Lys Cys Arg Glu Cys Asn Ser Tyr 
705                 710                 715                 720 


Val Tyr Phe Gln Gly Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys His 
                725                 730                 735     


Lys Lys Cys Leu Glu Thr Leu Ala Ile Gln Cys Gly His Lys Lys Leu 
            740                 745                 750         


Gln Gly Arg Leu Gln Leu Phe Gly Gln Asp Phe Ser His Ala Ala Arg 
        755                 760                 765             


Ser Ala Pro Asp Gly Val Pro Phe Ile Val Lys Lys Cys Val Cys Glu 
    770                 775                 780                 


Ile Glu Arg Arg Ala Leu Arg Thr Lys Gly Ile Tyr Arg Val Asn Gly 
785                 790                 795                 800 


Val Lys Thr Arg Val Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly Lys 
                805                 810                 815     


Glu Leu Val Glu Leu Ser Gln Ala Ser Pro His Asp Ile Ser Asn Val 
            820                 825                 830         


Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe Arg 
        835                 840                 845             


Leu Tyr His Glu Leu Val Gly Leu Ala Lys Asp Ser Leu Lys Ala Glu 
    850                 855                 860                 


Ala Glu Ala Lys Ala Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu Ser 
865                 870                 875                 880 


Glu Ala Val Ala Val Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu Arg 
                885                 890                 895     


Asp Leu Pro Pro Glu Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg His 
            900                 905                 910         


Leu Arg Arg Ile Val Glu Val Glu Gln Asp Asn Lys Met Thr Pro Gly 
        915                 920                 925             


Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Leu Arg Pro Arg Pro Thr 
    930                 935                 940                 


Glu Ala Thr Val Ser Leu Ser Ser Leu Val Asp Tyr Pro His Gln Ala 
945                 950                 955                 960 


Arg Val Ile Glu Thr Leu Ile Val His Tyr Gly Leu Val Phe Glu Glu 
                965                 970                 975     


Glu Pro Glu Glu Thr Pro Gly Gly Gln Asp Glu Ser Ser Asn Gln Arg 
            980                 985                 990         


Ala Glu Val Val Val Gln Val Pro  Tyr Leu Glu Ala Gly  Glu Ala Val 
        995                 1000                 1005             


Val Tyr  Pro Leu Gln Glu Ala  Ala Ala Asp Gly Cys  Arg Glu Ser 
    1010                 1015                 1020             


Arg Val  Val Ser Asn Asp Ser  Asp Ser Asp Leu Glu  Glu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Leu Ser Ser Ser Glu  Ala Ser Ala Leu Gly  His Leu Ser 
    1040                 1045                 1050             


Phe Leu  Glu Gln Gln Gln Ser  Glu Ala Ser Leu Glu  Val Ala Ser 
    1055                 1060                 1065             


Gly Ser  His Ser Gly Ser Glu  Glu Gln Leu Glu Ala  Thr Ala Arg 
    1070                 1075                 1080             


Glu Asp  Gly Asp Gly Asp Glu  Asp Gly Pro Ala Gln  Gln Leu Ser 
    1085                 1090                 1095             


Gly Phe  Asn Thr Asn Gln Ser  Asn Asn Val Leu Gln  Ala Pro Leu 
    1100                 1105                 1110             


Pro Pro  Met Arg Leu Arg Gly  Gly Arg Met Thr Leu  Gly Ser Cys 
    1115                 1120                 1125             


Arg Glu  Arg Gln Pro Glu Phe  Val 
    1130                 1135     


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

Val Leu His Asp Asp Leu Leu Glu Ala 
1               5                   


<210>  3
<211>  1136
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Phe Ser Arg Lys Lys Arg Glu Leu Met Lys Thr Pro Ser Ile Ser 
1               5                   10                  15      


Lys Lys Asn Arg Ala Gly Ser Pro Ser Pro Gln Pro Ser Gly Glu Leu 
            20                  25                  30          


Pro Arg Lys Asp Gly Ala Asp Ala Val Phe Pro Gly Pro Ser Leu Glu 
        35                  40                  45              


Pro Pro Ala Gly Ser Ser Gly Val Lys Ala Thr Gly Thr Leu Lys Arg 
    50                  55                  60                  


Pro Thr Ser Leu Ser Arg His Ala Ser Ala Ala Gly Phe Pro Leu Ser 
65                  70                  75                  80  


Gly Ala Ala Ser Trp Thr Leu Gly Arg Ser His Arg Ser Pro Leu Thr 
                85                  90                  95      


Ala Ala Ser Pro Gly Glu Leu Pro Thr Glu Gly Ala Gly Pro Asp Val 
            100                 105                 110         


Val Glu Asp Ile Ser His Leu Leu Ala Asp Val Ala Arg Phe Ala Glu 
        115                 120                 125             


Gly Leu Glu Lys Leu Lys Glu Cys Val Leu Arg Asp Asp Leu Leu Glu 
    130                 135                 140                 


Ala Arg Arg Pro Arg Ala His Glu Cys Leu Gly Glu Ala Leu Arg Val 
145                 150                 155                 160 


Met His Gln Ile Ile Ser Lys Tyr Pro Leu Leu Asn Thr Val Glu Thr 
                165                 170                 175     


Leu Thr Ala Ala Gly Thr Leu Ile Ala Lys Val Lys Ala Phe His Tyr 
            180                 185                 190         


Glu Ser Asn Asn Asp Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu Glu 
        195                 200                 205             


Thr Ile Ala Val Ala Phe Ser Ser Thr Val Ser Glu Phe Leu Met Gly 
    210                 215                 220                 


Glu Val Asp Ser Ser Thr Leu Leu Ala Val Pro Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Gln Ser Met Glu Ser Leu Tyr Gly Pro Gly Ser Glu Gly Thr Pro Pro 
                245                 250                 255     


Ser Leu Glu Asp Cys Asp Ala Gly Cys Leu Pro Ala Glu Glu Val Asp 
            260                 265                 270         


Val Leu Leu Gln Arg Cys Glu Gly Gly Val Asp Ala Ala Leu Leu Tyr 
        275                 280                 285             


Ala Lys Asn Met Ala Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu Glu 
    290                 295                 300                 


Lys Arg Thr Thr Leu Glu Met Glu Phe Ala Lys Gly Leu Gln Lys Ile 
305                 310                 315                 320 


Ala His Asn Cys Arg Gln Ser Val Met Gln Glu Pro His Met Pro Leu 
                325                 330                 335     


Leu Ser Ile Tyr Ser Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly His 
            340                 345                 350         


Ser Met Val Gln Ala Val Gly Thr Leu Gln Thr Gln Thr Phe Met Gln 
        355                 360                 365             


Pro Leu Thr Leu Arg Arg Leu Glu His Glu Lys Arg Arg Lys Glu Ile 
    370                 375                 380                 


Lys Glu Ala Trp His Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu Ser 
385                 390                 395                 400 


Asn Leu Arg Lys Ala Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp His 
                405                 410                 415     


Asp Lys Ala Arg Phe Leu Val Ala Lys Ala Glu Glu Glu Gln Ala Gly 
            420                 425                 430         


Ser Ala Pro Gly Ala Gly Ser Thr Ala Thr Lys Thr Leu Asp Lys Arg 
        435                 440                 445             


Arg Arg Leu Glu Glu Glu Ala Lys Asn Lys Ala Glu Glu Ala Met Ala 
    450                 455                 460                 


Thr Tyr Arg Thr Cys Val Ala Asp Ala Lys Thr Gln Lys Gln Glu Leu 
465                 470                 475                 480 


Glu Asp Thr Lys Val Thr Ala Leu Arg Gln Ile Gln Glu Val Ile Arg 
                485                 490                 495     


Gln Ser Asp Gln Thr Ile Lys Ser Ala Thr Ile Ser Tyr Tyr Gln Met 
            500                 505                 510         


Met His Met Gln Thr Ala Pro Leu Pro Val His Phe Gln Met Leu Cys 
        515                 520                 525             


Glu Ser Ser Lys Leu Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His Val 
    530                 535                 540                 


Arg Gln Leu Gln Arg Asp Gln Glu Pro Asp Val His Tyr Asp Phe Glu 
545                 550                 555                 560 


Pro His Val Ser Ala Asn Ala Trp Ser Pro Val Met Arg Ala Arg Lys 
                565                 570                 575     


Ser Ser Phe Asn Val Ser Asp Val Ala Arg Pro Glu Ala Ala Gly Ser 
            580                 585                 590         


Pro Pro Glu Glu Gly Gly Cys Thr Glu Gly Thr Pro Ala Lys Asp His 
        595                 600                 605             


Arg Ala Gly Arg Gly His Gln Val His Lys Ser Trp Pro Leu Ser Ile 
    610                 615                 620                 


Ser Asp Ser Asp Ser Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Glu Arg Thr Ser Ser Ser Gly Thr Met Ser Ser Thr Glu 
                645                 650                 655     


Glu Leu Val Asp Pro Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu Gln 
            660                 665                 670         


Ala Asp Leu Asn Gly Met Thr Pro Glu Leu Pro Val Ala Val Pro Ser 
        675                 680                 685             


Gly Pro Phe Arg His Glu Gly Leu Ser Lys Ala Ala Arg Thr His Arg 
    690                 695                 700                 


Leu Arg Lys Leu Arg Thr Pro Ala Lys Cys Arg Glu Cys Asn Ser Tyr 
705                 710                 715                 720 


Val Tyr Phe Gln Gly Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys His 
                725                 730                 735     


Lys Lys Cys Leu Glu Thr Leu Ala Ile Gln Cys Gly His Lys Lys Leu 
            740                 745                 750         


Gln Gly Arg Leu Gln Leu Phe Gly Gln Asp Phe Ser His Ala Ala Arg 
        755                 760                 765             


Ser Ala Pro Asp Gly Val Pro Phe Ile Val Lys Lys Cys Val Cys Glu 
    770                 775                 780                 


Ile Glu Arg Arg Ala Leu Arg Thr Lys Gly Ile Tyr Arg Val Asn Gly 
785                 790                 795                 800 


Val Lys Thr Arg Val Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly Lys 
                805                 810                 815     


Glu Leu Val Glu Leu Ser Gln Ala Ser Pro His Asp Ile Ser Asn Val 
            820                 825                 830         


Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe Arg 
        835                 840                 845             


Leu Tyr His Glu Leu Val Gly Leu Ala Lys Asp Ser Leu Lys Ala Glu 
    850                 855                 860                 


Ala Glu Ala Lys Ala Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu Ser 
865                 870                 875                 880 


Glu Ala Val Ala Val Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu Arg 
                885                 890                 895     


Asp Leu Pro Pro Glu Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg His 
            900                 905                 910         


Leu Arg Arg Ile Val Glu Val Glu Gln Asp Asn Lys Met Thr Pro Gly 
        915                 920                 925             


Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Leu Arg Pro Arg Pro Thr 
    930                 935                 940                 


Glu Ala Thr Val Ser Leu Ser Ser Leu Val Asp Tyr Pro His Gln Ala 
945                 950                 955                 960 


Arg Val Ile Glu Thr Leu Ile Val His Tyr Gly Leu Val Phe Glu Glu 
                965                 970                 975     


Glu Pro Glu Glu Thr Pro Gly Gly Gln Asp Glu Ser Ser Asn Gln Arg 
            980                 985                 990         


Ala Glu Val Val Val Gln Val Pro  Tyr Leu Glu Ala Gly  Glu Ala Val 
        995                 1000                 1005             


Val Tyr  Pro Leu Gln Glu Ala  Ala Ala Asp Gly Cys  Arg Glu Ser 
    1010                 1015                 1020             


Arg Val  Val Ser Asn Asp Ser  Asp Ser Asp Leu Glu  Glu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Leu Ser Ser Ser Glu  Ala Ser Ala Leu Gly  His Leu Ser 
    1040                 1045                 1050             


Phe Leu  Glu Gln Gln Gln Ser  Glu Ala Ser Leu Glu  Val Ala Ser 
    1055                 1060                 1065             


Gly Ser  His Ser Gly Ser Glu  Glu Gln Leu Glu Ala  Thr Ala Arg 
    1070                 1075                 1080             


Glu Asp  Gly Asp Gly Asp Glu  Asp Gly Pro Ala Gln  Gln Leu Ser 
    1085                 1090                 1095             


Gly Phe  Asn Thr Asn Gln Ser  Asn Asn Val Leu Gln  Ala Pro Leu 
    1100                 1105                 1110             


Pro Pro  Met Arg Leu Arg Gly  Gly Arg Met Thr Leu  Gly Ser Cys 
    1115                 1120                 1125             


Arg Glu  Arg Gln Pro Glu Phe  Val 
    1130                 1135     


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Leu Arg Asp Asp Leu Leu Glu Ala 
1               5                   


<210>  5
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Ser Ala Ser Asn Tyr 
1               5       


<210>  6
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Arg Ser Asn Val Gly Glu 
1               5           


<210>  7
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  7

Cys Ala Ala Ser Asp Leu Asn Phe 
1               5               


<210>  8
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Glu His Asn Arg 
1               5   


<210>  9
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  9

Phe Gln Asn Glu Ala Gln 
1               5       


<210>  10
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Ala Ser Ser Leu Val Ser Arg Val Asp Gly Tyr Thr Phe 
1               5                   10                  


<210>  11
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Gly Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Asp Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
        115                 120                 125         


<210>  12
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Val Ser Arg Val Asp Gly Tyr Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Val Glu 
    130                 


<210>  13
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with murinized constant region

<400>  13

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Gly Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Asp Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His Ile 
        115                 120                 125             


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
    130                 135                 140                 


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
145                 150                 155                 160 


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val Leu 
                165                 170                 175     


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
            180                 185                 190         


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
        195                 200                 205             


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
    210                 215                 220                 


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val Met 
225                 230                 235                 240 


Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
                245                 250                 255     


Thr Leu Arg Leu Trp Ser Ser 
            260             


<210>  14
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with murinized constant region

<400>  14

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Val Ser Arg Val Asp Gly Tyr Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Thr Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  15
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Ser Ala Ser Asn Tyr 
1               5       


<210>  16
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  16

Ile Arg Ser Asn Val Gly Glu 
1               5           


<210>  17
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  17

Cys Ala Ala His Thr Pro Gly Tyr Ser Thr Leu Thr Phe 
1               5                   10              


<210>  18
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Glu His Asn Arg 
1               5   


<210>  19
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  19

Phe Gln Asn Glu Ala Gln 
1               5       


<210>  20
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  20

Cys Ala Ser Ser Pro Arg Ala Gly Gly Glu Thr Gln Tyr Phe 
1               5                   10                  


<210>  21
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Gly Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala His 
            100                 105                 110         


Thr Pro Gly Tyr Ser Thr Leu Thr Phe Gly Lys Gly Thr Met Leu Leu 
        115                 120                 125             


Val Ser Pro Asp 
    130         


<210>  22
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Arg Ala Gly Gly Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu Glu 
    130                 


<210>  23
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with murinized constant region

<400>  23

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Gly Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala His 
            100                 105                 110         


Thr Pro Gly Tyr Ser Thr Leu Thr Phe Gly Lys Gly Thr Met Leu Leu 
        115                 120                 125             


Val Ser Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  24
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with murinized constant region

<400>  24

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Arg Ala Gly Gly Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Thr Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  25
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  25

Thr Ser Ile Asn Asn 
1               5   


<210>  26
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  26

Ile Arg Ser Asn Glu Arg Glu 
1               5           


<210>  27
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  27

Cys Ala Thr Gly Asp Gln Thr Gly Ala Asn Asn Leu Phe Phe 
1               5                   10                  


<210>  28
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  28

Ser Glu His Asn Arg 
1               5   


<210>  29
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  29

Phe Gln Asn Glu Ala Gln 
1               5       


<210>  30
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  30

Cys Ala Ser Ser Leu Thr Arg Thr Glu Lys Leu Phe Phe 
1               5                   10              


<210>  31
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Gly 
            100                 105                 110         


Asp Gln Thr Gly Ala Asn Asn Leu Phe Phe Gly Thr Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Ile Pro Tyr 
    130             


<210>  32
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Thr Arg Thr Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln 
        115                 120                 125             


Leu Ser Val Leu Glu 
    130             


<210>  33
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with murinized constant region

<400>  33

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Gly 
            100                 105                 110         


Asp Gln Thr Gly Ala Asn Asn Leu Phe Phe Gly Thr Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Ile Pro Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  34
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with murinized constant region

<400>  34

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Thr Arg Thr Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln 
        115                 120                 125             


Leu Ser Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Thr 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  35
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  35

Asp Ser Ala Ser Asn Tyr 
1               5       


<210>  36
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  36

Ile Arg Ser Asn Val Gly Glu 
1               5           


<210>  37
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  37

Cys Ala Gly Arg Gly Lys Leu Thr Phe 
1               5                   


<210>  38
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  38

Ser Glu His Asn Arg 
1               5   


<210>  39
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  39

Phe Gln Asn Glu Ala Gln 
1               5       


<210>  40
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  40

Cys Ala Ser Ser Leu Val Arg Asp Glu Lys Leu Phe Phe 
1               5                   10              


<210>  41
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Gly Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Gly Arg 
            100                 105                 110         


Gly Lys Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile Pro Asn 
        115                 120                 125             


<210>  42
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Val Arg Asp Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln 
        115                 120                 125             


Leu Ser Val Leu Glu 
    130             


<210>  43
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with murinized constant region

<400>  43

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Gly Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Gly Arg 
            100                 105                 110         


Gly Lys Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile Pro Asn 
        115                 120                 125             


Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
    130                 135                 140                 


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
145                 150                 155                 160 


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val 
                165                 170                 175     


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
            180                 185                 190         


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
        195                 200                 205             


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
    210                 215                 220                 


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val 
225                 230                 235                 240 


Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
                245                 250                 255     


Met Thr Leu Arg Leu Trp Ser Ser 
            260                 


<210>  44
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with murinized constant region

<400>  44

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Val Arg Asp Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln 
        115                 120                 125             


Leu Ser Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Thr 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  45
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  45

Ser Val Phe Ser Ser 
1               5   


<210>  46
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  46

Val Val Thr Gly Gly Glu Val 
1               5           


<210>  47
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  47

Cys Ala Gly Ala Gly Asn Asn Asp Met Arg Phe 
1               5                   10      


<210>  48
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  48

Ser Glu His Asn Arg 
1               5   


<210>  49
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  49

Phe Gln Asn Glu Ala Gln 
1               5       


<210>  50
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  50

Cys Ala Ser Ser Leu Val Arg Gly Ile Glu Ala Phe Phe 
1               5                   10              


<210>  51
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Val Leu Lys Phe Ser Val Ser Ile Leu Trp Ile Gln Leu Ala Trp 
1               5                   10                  15      


Val Ser Thr Gln Leu Leu Glu Gln Ser Pro Gln Phe Leu Ser Ile Gln 
            20                  25                  30          


Glu Gly Glu Asn Leu Thr Val Tyr Cys Asn Ser Ser Ser Val Phe Ser 
        35                  40                  45              


Ser Leu Gln Trp Tyr Arg Gln Glu Pro Gly Glu Gly Pro Val Leu Leu 
    50                  55                  60                  


Val Thr Val Val Thr Gly Gly Glu Val Lys Lys Leu Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Asp Ala Arg Lys Asp Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Ala Gln Thr Gly Asp Thr Gly Leu Tyr Leu Cys Ala Gly Ala Gly Asn 
            100                 105                 110         


Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Asn 
        115                 120                 125             


<210>  52
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Val Arg Gly Ile Glu Ala Phe Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu 
    130             


<210>  53
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with murinized constant region

<400>  53

Met Val Leu Lys Phe Ser Val Ser Ile Leu Trp Ile Gln Leu Ala Trp 
1               5                   10                  15      


Val Ser Thr Gln Leu Leu Glu Gln Ser Pro Gln Phe Leu Ser Ile Gln 
            20                  25                  30          


Glu Gly Glu Asn Leu Thr Val Tyr Cys Asn Ser Ser Ser Val Phe Ser 
        35                  40                  45              


Ser Leu Gln Trp Tyr Arg Gln Glu Pro Gly Glu Gly Pro Val Leu Leu 
    50                  55                  60                  


Val Thr Val Val Thr Gly Gly Glu Val Lys Lys Leu Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Asp Ala Arg Lys Asp Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Ala Gln Thr Gly Asp Thr Gly Leu Tyr Leu Cys Ala Gly Ala Gly Asn 
            100                 105                 110         


Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Asn 
        115                 120                 125             


Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
    130                 135                 140                 


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
145                 150                 155                 160 


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val 
                165                 170                 175     


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
            180                 185                 190         


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
        195                 200                 205             


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
    210                 215                 220                 


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val 
225                 230                 235                 240 


Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
                245                 250                 255     


Met Thr Leu Arg Leu Trp Ser Ser 
            260                 


<210>  54
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with murinized constant region

<400>  54

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Val Arg Gly Ile Glu Ala Phe Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Thr 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  55
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  55

Asp Ser Ser Ser Thr Tyr 
1               5       


<210>  56
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  56

Ile Phe Ser Asn Met Asp Met 
1               5           


<210>  57
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  57

Cys Ala Glu Lys Trp Ile Ile Phe 
1               5               


<210>  58
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  58

Ser Glu His Asn Arg 
1               5   


<210>  59
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  59

Phe Gln Asn Glu Ala Gln 
1               5       


<210>  60
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  60

Cys Ala Ser Ser Leu Thr Thr Pro Asp Gly Tyr Thr Phe 
1               5                   10              


<210>  61
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Lys Trp Ile Ile Phe Gly Lys Gly Thr Arg Leu His Ile Leu Pro Asn 
        115                 120                 125             


<210>  62
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Thr Thr Pro Asp Gly Tyr Thr Phe Gly Ser Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu 
    130             


<210>  63
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with murinized constant region

<400>  63

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Lys Trp Ile Ile Phe Gly Lys Gly Thr Arg Leu His Ile Leu Pro Asn 
        115                 120                 125             


Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
    130                 135                 140                 


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
145                 150                 155                 160 


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val 
                165                 170                 175     


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
            180                 185                 190         


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
        195                 200                 205             


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
    210                 215                 220                 


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val 
225                 230                 235                 240 


Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
                245                 250                 255     


Met Thr Leu Arg Leu Trp Ser Ser 
            260                 


<210>  64
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with murinized constant region

<400>  64

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Thr Thr Pro Asp Gly Tyr Thr Phe Gly Ser Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Thr 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control Peptide Astn1 P1268L

<400>  65

Lys Leu Tyr Gly Leu Asp Trp Ala Glu Leu 
1               5                   10  


<210>  66
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  66
gacagcgcca gcaactac                                                     18


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  67
atcagatcca acgtgggcga g                                                 21


<210>  68
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  68
tgcgccgcca gcgacctgaa tttt                                              24


<210>  69
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  69
agcgagcaca accgg                                                        15


<210>  70
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  70
ttccagaacg aggcccag                                                     18


<210>  71
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  71
tgtgccagca gcctggtgtc cagagtggat ggctacacat tt                          42


<210>  72
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  72
atgaccagca tccgggccgt gttcatcttc ctgtggctgc agctggacct ggtcaacggc       60

gagaatgtgg aacagcaccc cagcacactg agcgtgcaag agggcgattc tgccgtgatc      120

aagtgcacct acagcgacag cgccagcaac tacttcccct ggtacaagca agaactcggc      180

aagggccctc agctgatcat cgacatcaga tccaacgtgg gcgagaagaa ggaccagcgg      240

attgccgtga cactgaacaa gaccgccaag cacttcagcc tgcacatcac cgagacacag      300

cctgaggata gcgccgtgta cttttgcgcc gccagcgacc tgaattttgg caagggcaca      360

agcctgctgg tcacccctc                                                   379


<210>  73
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  73
atgggcacaa gcctgctgtg ttggatggcc ctgtgtctgc tgggagccga tcatgccgat       60

acgggagtgt ctcagaaccc cagacacaag atcaccaagc ggggccagaa cgtgaccttc      120

agatgcgacc ctatcagcga gcacaaccgg ctgtactggt acagacagac actcggccag      180

ggacctgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag cagactgctg      240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagaga      300

accgagcagg gcgacagcgc catgtatctg tgtgccagca gcctggtgtc cagagtggat      360

ggctacacat ttggcagcgg caccagactg acagtggtgg                            400


<210>  74
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human (codon optimized) with murinized constant region

<400>  74
atgaccagca tccgggccgt gttcatcttc ctgtggctgc agctggacct ggtcaacggc       60

gagaatgtgg aacagcaccc cagcacactg agcgtgcaag agggcgattc tgccgtgatc      120

aagtgcacct acagcgacag cgccagcaac tacttcccct ggtacaagca agaactcggc      180

aagggccctc agctgatcat cgacatcaga tccaacgtgg gcgagaagaa ggaccagcgg      240

attgccgtga cactgaacaa gaccgccaag cacttcagcc tgcacatcac cgagacacag      300

cctgaggata gcgccgtgta cttttgcgcc gccagcgacc tgaattttgg caagggcaca      360

agcctgctgg tcacccctca catccagaat ccggagcccg ccgtatacca gctgaaggac      420

cctagaagcc aggacagcac cctgtgcctg ttcaccgact tcgacagcca gatcaacgtg      480

cccaagacca tggaaagcgg caccttcatc accgacaaga cagtgctgga catgaaggcc      540

atggacagca agtccaacgg cgcaatcgcc tggtccaacc agaccagctt cacatgccag      600

gacatcttca aagagacaaa cgccacatac cccagcagcg acgtgccctg tgatgccacc      660

ctgacagaga agtccttcga gacagacatg aacctgaact tccagaatct gtccgtgatg      720

ggcctgagaa tcctgctgct gaaggtggcc ggcttcaatc tgctgatgac cctgcggctg      780

tggtccagct ga                                                          792


<210>  75
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human (codon optimized) with murinized constant region

<400>  75
atgggcacaa gcctgctgtg ttggatggcc ctgtgtctgc tgggagccga tcatgccgat       60

acgggagtgt ctcagaaccc cagacacaag atcaccaagc ggggccagaa cgtgaccttc      120

agatgcgacc ctatcagcga gcacaaccgg ctgtactggt acagacagac actcggccag      180

ggacctgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag cagactgctg      240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagaga      300

accgagcagg gcgacagcgc catgtatctg tgtgccagca gcctggtgtc cagagtggat      360

ggctacacat ttggcagcgg caccagactg acagtggtgg aagatctccg gaacgtgacc      420

ccccctaaag tgaccctgtt cgaacccagc aaggccgaga tcgccaacaa gcagaaagcc      480

accctcgtgt gcctggccag aggcttcttc cccgaccatg tggaactgtc ttggtgggtc      540

aacggcaaag aggtgcacag cggagtgtcc accgaccctc aggcctacaa agagagcaac      600

tacagctact gcctgagcag cagactgcgg gtgtccgcca ccttctggca caacccccgg      660

aaccacttca gatgccaggt gcagtttcac ggcctgagcg aagaggacaa gtggcccgaa      720

ggctccccca agcccgtgac ccagaatatc tctgccgagg cctggggcag agccgactgt      780

ggaattacca gcgccagcta ccaccagggc gtgctgtctg ccaccatcct gtacgagatc      840

ctgctgggca aggccaccct gtacgccgtg ctggtgtctg gcctggtgct gatggccatg      900

gtcaagaaga agaacagctg a                                                921


<210>  76
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  76
gacagcgcca gcaactac                                                     18


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  77
atcagatcca acgtgggcga g                                                 21


<210>  78
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  78
tgcgccgctc acacacctgg ctacagcacc ctgacattt                              39


<210>  79
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  79
agcgagcaca accgg                                                        15


<210>  80
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  80
ttccagaacg aggcccag                                                     18


<210>  81
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  81
tgtgctagct ctcctagagc cggcggagag acacagtatt tc                          42


<210>  82
<211>  394
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  82
atgaccagca tccgggccgt gttcatcttc ctgtggctgc agctggacct ggtcaacggc       60

gagaatgtgg aacagcaccc cagcacactg agcgtgcaag agggcgattc tgccgtgatc      120

aagtgcacct acagcgacag cgccagcaac tacttcccct ggtacaagca agaactcggc      180

aagggccctc agctgatcat cgacatcaga tccaacgtgg gcgagaagaa ggaccagcgg      240

attgccgtga cactgaacaa gaccgccaag cacttcagcc tgcacatcac cgagacacag      300

cctgaggata gcgccgtgta cttctgcgcc gctcacacac ctggctacag caccctgaca      360

tttggcaagg gcaccatgct gctggtgtcc ccag                                  394


<210>  83
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  83
atgggcacaa gcctgctgtg ttggatggcc ctgtgtctgc tgggagccga tcatgccgat       60

acgggagtgt ctcagaaccc cagacacaag atcaccaagc ggggccagaa cgtgaccttc      120

agatgcgacc ctatcagcga gcacaaccgg ctgtactggt acagacagac actcggccag      180

ggacctgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag cagactgctg      240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagaga      300

accgagcagg gcgacagcgc catgtacctg tgtgctagct ctcctagagc cggcggagag      360

acacagtatt tcggccctgg aacacggctg ctggttctgg                            400


<210>  84
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human (codon optimized) with murinized constant region

<400>  84
atgaccagca tccgggccgt gttcatcttc ctgtggctgc agctggacct ggtcaacggc       60

gagaatgtgg aacagcaccc cagcacactg agcgtgcaag agggcgattc tgccgtgatc      120

aagtgcacct acagcgacag cgccagcaac tacttcccct ggtacaagca agaactcggc      180

aagggccctc agctgatcat cgacatcaga tccaacgtgg gcgagaagaa ggaccagcgg      240

attgccgtga cactgaacaa gaccgccaag cacttcagcc tgcacatcac cgagacacag      300

cctgaggata gcgccgtgta cttctgcgcc gctcacacac ctggctacag caccctgaca      360

tttggcaagg gcaccatgct gctggtgtcc ccagacatcc agaatccgga gcccgccgta      420

taccagctga aggaccctag aagccaggac agcaccctgt gcctgttcac cgacttcgac      480

agccagatca acgtgcccaa gaccatggaa agcggcacct tcatcaccga caagacagtg      540

ctggacatga aggccatgga cagcaagtcc aacggcgcaa tcgcctggtc caaccagacc      600

agcttcacat gccaggacat cttcaaagag acaaacgcca cataccccag cagcgacgtg      660

ccctgtgatg ccaccctgac agagaagtcc ttcgagacag acatgaacct gaacttccag      720

aatctgtccg tgatgggcct gagaatcctg ctgctgaagg tggccggctt caatctgctg      780

atgaccctgc ggctgtggtc cagctga                                          807


<210>  85
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human (codon optimized) with murinized constant region

<400>  85
atgggcacaa gcctgctgtg ttggatggcc ctgtgtctgc tgggagccga tcatgccgat       60

acgggagtgt ctcagaaccc cagacacaag atcaccaagc ggggccagaa cgtgaccttc      120

agatgcgacc ctatcagcga gcacaaccgg ctgtactggt acagacagac actcggccag      180

ggacctgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag cagactgctg      240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagaga      300

accgagcagg gcgacagcgc catgtacctg tgtgctagct ctcctagagc cggcggagag      360

acacagtatt tcggccctgg aacacggctg ctggttctgg aagatctccg gaacgtgacc      420

ccccctaaag tgaccctgtt cgaacccagc aaggccgaga tcgccaacaa gcagaaagcc      480

accctcgtgt gcctggccag aggcttcttc cccgaccatg tggaactgtc ttggtgggtc      540

aacggcaaag aggtgcacag cggagtgtcc accgaccctc aggcctacaa agagagcaac      600

tacagctact gcctgagcag cagactgcgg gtgtccgcca ccttctggca caacccccgg      660

aaccacttca gatgccaggt gcagtttcac ggcctgagcg aagaggacaa gtggcccgaa      720

ggctccccca agcccgtgac ccagaatatc tctgccgagg cctggggcag agccgactgt      780

ggaattacca gcgccagcta ccaccagggc gtgctgtctg ccaccatcct gtacgagatc      840

ctgctgggca aggccaccct gtacgccgtg ctggtgtctg gcctggtgct gatggccatg      900

gtcaagaaga agaacagctg a                                                921


<210>  86
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  86
accagcatca acaac                                                        15


<210>  87
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  87
atcagaagca acgagagaga g                                                 21


<210>  88
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  88
tgcgccactg gcgatcagac cggcgccaac aatctgttct tt                          42


<210>  89
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  89
agcgagcaca accgg                                                        15


<210>  90
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  90
ttccagaacg aggcccag                                                     18


<210>  91
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  91
tgtgccagca gcctgaccag aaccgagaag ctgtttttc                              39


<210>  92
<211>  397
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  92
atggaaacac tgctgggcgt gtccctggtc atcctgtggc tgcaactggc cagagtgaac       60

agccagcagg gcgaagaaga tccccaggct ctgtctatcc aagagggcga gaacgccacc      120

atgaactgca gctacaagac cagcatcaac aacctgcagt ggtacagaca gaacagcggc      180

agaggactgg tgcacctgat cctgatcaga agcaacgaga gagagaagca ctccggcaga      240

ctgagagtga ccctggacac cagcaagaag tccagcagcc tgctgatcac cgcctctaga      300

gctgccgata ccgccagcta cttttgcgcc actggcgatc agaccggcgc caacaatctg      360

ttctttggca ccggaaccag gctgacagtg atccctt                               397


<210>  93
<211>  397
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  93
atgggcacaa gcctgctgtg ttggatggcc ctgtgtctgc tgggagccga tcatgccgat       60

acgggagtgt ctcagaaccc cagacacaag atcaccaagc ggggccagaa cgtgaccttc      120

agatgcgacc ctatcagcga gcacaaccgg ctgtactggt acagacagac actcggccag      180

ggacctgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag cagactgctg      240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagaga      300

accgagcagg gcgacagcgc catgtatctg tgtgccagca gcctgaccag aaccgagaag      360

ctgtttttcg gcagcggcac ccagctgtct gttctgg                               397


<210>  94
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human (codon optimized) with murinized constant region

<400>  94
atggaaacac tgctgggcgt gtccctggtc atcctgtggc tgcaactggc cagagtgaac       60

agccagcagg gcgaagaaga tccccaggct ctgtctatcc aagagggcga gaacgccacc      120

atgaactgca gctacaagac cagcatcaac aacctgcagt ggtacagaca gaacagcggc      180

agaggactgg tgcacctgat cctgatcaga agcaacgaga gagagaagca ctccggcaga      240

ctgagagtga ccctggacac cagcaagaag tccagcagcc tgctgatcac cgcctctaga      300

gctgccgata ccgccagcta cttttgcgcc actggcgatc agaccggcgc caacaatctg      360

ttctttggca ccggaaccag gctgacagtg atcccttaca tccagaatcc ggagcccgcc      420

gtataccagc tgaaggaccc tagaagccag gacagcaccc tgtgcctgtt caccgacttc      480

gacagccaga tcaacgtgcc caagaccatg gaaagcggca ccttcatcac cgacaagaca      540

gtgctggaca tgaaggccat ggacagcaag tccaacggcg caatcgcctg gtccaaccag      600

accagcttca catgccagga catcttcaaa gagacaaacg ccacataccc cagcagcgac      660

gtgccctgtg atgccaccct gacagagaag tccttcgaga cagacatgaa cctgaacttc      720

cagaatctgt ccgtgatggg cctgagaatc ctgctgctga aggtggccgg cttcaatctg      780

ctgatgaccc tgcggctgtg gtccagctga                                       810


<210>  95
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human (codon optimized) with murinized constant region

<400>  95
atgggcacaa gcctgctgtg ttggatggcc ctgtgtctgc tgggagccga tcatgccgat       60

acgggagtgt ctcagaaccc cagacacaag atcaccaagc ggggccagaa cgtgaccttc      120

agatgcgacc ctatcagcga gcacaaccgg ctgtactggt acagacagac actcggccag      180

ggacctgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag cagactgctg      240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagaga      300

accgagcagg gcgacagcgc catgtatctg tgtgccagca gcctgaccag aaccgagaag      360

ctgtttttcg gcagcggcac ccagctgtct gttctggaag atctccggaa cgtgaccccc      420

cctaaagtga ccctgttcga acccagcaag gccgagatcg ccaacaagca gaaagccacc      480

ctcgtgtgcc tggccagagg cttcttcccc gaccatgtgg aactgtcttg gtgggtcaac      540

ggcaaagagg tgcacagcgg agtgtccacc gaccctcagg cctacaaaga gagcaactac      600

agctactgcc tgagcagcag actgcgggtg tccgccacct tctggcacaa cccccggaac      660

cacttcagat gccaggtgca gtttcacggc ctgagcgaag aggacaagtg gcccgaaggc      720

tcccccaagc ccgtgaccca gaatatctct gccgaggcct ggggcagagc cgactgtgga      780

attaccagcg ccagctacca ccagggcgtg ctgtctgcca ccatcctgta cgagatcctg      840

ctgggcaagg ccaccctgta cgccgtgctg gtgtctggcc tggtgctgat ggccatggtc      900

aagaagaaga acagctga                                                    918


<210>  96
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  96
gacagcgcca gcaactac                                                     18


<210>  97
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  97
atcagatcca acgtgggcga g                                                 21


<210>  98
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  98
tgtgccggca gaggcaagct gaccttt                                           27


<210>  99
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  99
agcgagcaca accgg                                                        15


<210>  100
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  100
ttccagaacg aggcccag                                                     18


<210>  101
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  101
tgtgccagtt ctctcgtgcg ggacgagaag ctgtttttc                              39


<210>  102
<211>  382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  102
atgaccagca tccgggccgt gttcatcttc ctgtggctgc agctggacct ggtcaacggc       60

gagaatgtgg aacagcaccc cagcacactg agcgtgcaag agggcgattc tgccgtgatc      120

aagtgcacct acagcgacag cgccagcaac tacttcccct ggtacaagca agaactcggc      180

aagggccctc agctgatcat cgacatcaga tccaacgtgg gcgagaagaa ggaccagcgg      240

attgccgtga cactgaacaa gaccgccaag cacttcagcc tgcacatcac cgagacacag      300

cctgaggata gcgccgtgta cttctgtgcc ggcagaggca agctgacctt tggcacaggc      360

acccggctga caatcatccc ta                                               382


<210>  103
<211>  397
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  103
atgggcacaa gcctgctgtg ttggatggcc ctgtgtctgc tgggagccga tcatgccgat       60

acgggagtgt ctcagaaccc cagacacaag atcaccaagc ggggccagaa cgtgaccttc      120

agatgcgacc ctatcagcga gcacaaccgg ctgtactggt acagacagac actcggccag      180

ggacctgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag cagactgctg      240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagaga      300

accgagcagg gcgacagcgc catgtatctg tgtgccagtt ctctcgtgcg ggacgagaag      360

ctgtttttcg gcagcggcac acagctgagc gttctgg                               397


<210>  104
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human (codon optimized) with murinized constant region

<400>  104
atgaccagca tccgggccgt gttcatcttc ctgtggctgc agctggacct ggtcaacggc       60

gagaatgtgg aacagcaccc cagcacactg agcgtgcaag agggcgattc tgccgtgatc      120

aagtgcacct acagcgacag cgccagcaac tacttcccct ggtacaagca agaactcggc      180

aagggccctc agctgatcat cgacatcaga tccaacgtgg gcgagaagaa ggaccagcgg      240

attgccgtga cactgaacaa gaccgccaag cacttcagcc tgcacatcac cgagacacag      300

cctgaggata gcgccgtgta cttctgtgcc ggcagaggca agctgacctt tggcacaggc      360

acccggctga caatcatccc taacatccag aatccggagc ccgccgtata ccagctgaag      420

gaccctagaa gccaggacag caccctgtgc ctgttcaccg acttcgacag ccagatcaac      480

gtgcccaaga ccatggaaag cggcaccttc atcaccgaca agacagtgct ggacatgaag      540

gccatggaca gcaagtccaa cggcgcaatc gcctggtcca accagaccag cttcacatgc      600

caggacatct tcaaagagac aaacgccaca taccccagca gcgacgtgcc ctgtgatgcc      660

accctgacag agaagtcctt cgagacagac atgaacctga acttccagaa tctgtccgtg      720

atgggcctga gaatcctgct gctgaaggtg gccggcttca atctgctgat gaccctgcgg      780

ctgtggtcca gctga                                                       795


<210>  105
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human (codon omptimized) with murinized constant region

<400>  105
atgggcacaa gcctgctgtg ttggatggcc ctgtgtctgc tgggagccga tcatgccgat       60

acgggagtgt ctcagaaccc cagacacaag atcaccaagc ggggccagaa cgtgaccttc      120

agatgcgacc ctatcagcga gcacaaccgg ctgtactggt acagacagac actcggccag      180

ggacctgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag cagactgctg      240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagaga      300

accgagcagg gcgacagcgc catgtatctg tgtgccagtt ctctcgtgcg ggacgagaag      360

ctgtttttcg gcagcggcac acagctgagc gttctggaag atctccggaa cgtgaccccc      420

cctaaagtga ccctgttcga acccagcaag gccgagatcg ccaacaagca gaaagccacc      480

ctcgtgtgcc tggccagagg cttcttcccc gaccatgtgg aactgtcttg gtgggtcaac      540

ggcaaagagg tgcacagcgg agtgtccacc gaccctcagg cctacaaaga gagcaactac      600

agctactgcc tgagcagcag actgcgggtg tccgccacct tctggcacaa cccccggaac      660

cacttcagat gccaggtgca gtttcacggc ctgagcgaag aggacaagtg gcccgaaggc      720

tcccccaagc ccgtgaccca gaatatctct gccgaggcct ggggcagagc cgactgtgga      780

attaccagcg ccagctacca ccagggcgtg ctgtctgcca ccatcctgta cgagatcctg      840

ctgggcaagg ccaccctgta cgccgtgctg gtgtctggcc tggtgctgat ggccatggtc      900

aagaagaaga acagctga                                                    918


<210>  106
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  106
agcgtgttca gcagc                                                        15


<210>  107
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  107
gttgtgacag gcggcgaagt g                                                 21


<210>  108
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  108
tgtgccggcg ctggcaacaa cgacatgaga ttt                                    33


<210>  109
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  109
agcgagcaca accgg                                                        15


<210>  110
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  110
ttccagaacg aggcccag                                                     18


<210>  111
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  111
tgtgcctctt ctctcgtgcg gggcatcgag gcctttttt                              39


<210>  112
<211>  382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  112
atggtgctga agttcagcgt gtccatcctg tggatccagc tggcctgggt ttccacacag       60

ctgctggaac agagccctca gttcctgagc atccaagagg gcgagaacct gaccgtgtac      120

tgcaacagca gcagcgtgtt cagcagcctg cagtggtaca gacaagagcc tggcgaagga      180

cctgtgctgc tggtcacagt tgtgacaggc ggcgaagtga agaagctgaa gcggctgacc      240

ttccagttcg gcgacgccag aaaggatagc tccctgcaca ttaccgccgc tcagacaggc      300

gataccggcc tgtatctttg tgccggcgct ggcaacaacg acatgagatt tggcgccgga      360

accagactga ccgtgaagcc ta                                               382


<210>  113
<211>  397
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  113
atgggcacaa gcctgctgtg ttggatggcc ctgtgtctgc tgggagccga tcatgccgat       60

acgggagtgt ctcagaaccc cagacacaag atcaccaagc ggggccagaa cgtgaccttc      120

agatgcgacc ctatcagcga gcacaaccgg ctgtactggt acagacagac actcggccag      180

ggacctgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag cagactgctg      240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagaga      300

accgagcagg gcgacagcgc catgtatctg tgtgcctctt ctctcgtgcg gggcatcgag      360

gccttttttg gccaaggcac cagactgacc gtggtgg                               397


<210>  114
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human (codon optimized) with murinized constant region

<400>  114
atggtgctga agttcagcgt gtccatcctg tggatccagc tggcctgggt ttccacacag       60

ctgctggaac agagccctca gttcctgagc atccaagagg gcgagaacct gaccgtgtac      120

tgcaacagca gcagcgtgtt cagcagcctg cagtggtaca gacaagagcc tggcgaagga      180

cctgtgctgc tggtcacagt tgtgacaggc ggcgaagtga agaagctgaa gcggctgacc      240

ttccagttcg gcgacgccag aaaggatagc tccctgcaca ttaccgccgc tcagacaggc      300

gataccggcc tgtatctttg tgccggcgct ggcaacaacg acatgagatt tggcgccgga      360

accagactga ccgtgaagcc taacatccag aatccggagc ccgccgtata ccagctgaag      420

gaccctagaa gccaggacag caccctgtgc ctgttcaccg acttcgacag ccagatcaac      480

gtgcccaaga ccatggaaag cggcaccttc atcaccgaca agacagtgct ggacatgaag      540

gccatggaca gcaagtccaa cggcgcaatc gcctggtcca accagaccag cttcacatgc      600

caggacatct tcaaagagac aaacgccaca taccccagca gcgacgtgcc ctgtgatgcc      660

accctgacag agaagtcctt cgagacagac atgaacctga acttccagaa tctgtccgtg      720

atgggcctga gaatcctgct gctgaaggtg gccggcttca atctgctgat gaccctgcgg      780

ctgtggtcca gctga                                                       795


<210>  115
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human (codon opimized) with murinized constant region

<400>  115
atgggcacaa gcctgctgtg ttggatggcc ctgtgtctgc tgggagccga tcatgccgat       60

acgggagtgt ctcagaaccc cagacacaag atcaccaagc ggggccagaa cgtgaccttc      120

agatgcgacc ctatcagcga gcacaaccgg ctgtactggt acagacagac actcggccag      180

ggacctgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag cagactgctg      240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagaga      300

accgagcagg gcgacagcgc catgtatctg tgtgcctctt ctctcgtgcg gggcatcgag      360

gccttttttg gccaaggcac cagactgacc gtggtggaag atctccggaa cgtgaccccc      420

cctaaagtga ccctgttcga acccagcaag gccgagatcg ccaacaagca gaaagccacc      480

ctcgtgtgcc tggccagagg cttcttcccc gaccatgtgg aactgtcttg gtgggtcaac      540

ggcaaagagg tgcacagcgg agtgtccacc gaccctcagg cctacaaaga gagcaactac      600

agctactgcc tgagcagcag actgcgggtg tccgccacct tctggcacaa cccccggaac      660

cacttcagat gccaggtgca gtttcacggc ctgagcgaag aggacaagtg gcccgaaggc      720

tcccccaagc ccgtgaccca gaatatctct gccgaggcct ggggcagagc cgactgtgga      780

attaccagcg ccagctacca ccagggcgtg ctgtctgcca ccatcctgta cgagatcctg      840

ctgggcaagg ccaccctgta cgccgtgctg gtgtctggcc tggtgctgat ggccatggtc      900

aagaagaaga acagctga                                                    918


<210>  116
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  116
gacagctcct ccacctac                                                     18


<210>  117
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  117
attttttcaa atatggacat g                                                 21


<210>  118
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  118
tgtgcagaga aatggatcat cttt                                              24


<210>  119
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  119
agcgagcaca accgg                                                        15


<210>  120
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  120
ttccagaacg aggcccag                                                     18


<210>  121
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  121
tgtgccagca gcctgaccac acctgacggc tacacattt                              39


<210>  122
<211>  382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  122
atgaagacat ttgctggatt ttcgttcctg tttttgtggc tgcagctgga ctgtatgagt       60

agaggagagg atgtggagca gagtcttttc ctgagtgtcc gagagggaga cagctccgtt      120

ataaactgca cttacacaga cagctcctcc acctacttat actggtataa gcaagaacct      180

ggagcaggtc tccagttgct gacgtatatt ttttcaaata tggacatgaa acaagaccaa      240

agactcactg ttctattgaa taaaaaggat aaacatctgt ctctgcgcat tgcagacacc      300

cagactgggg actcagctat ctacttctgt gcagagaaat ggatcatctt tggaaaaggg      360

acacgacttc atattctccc ca                                               382


<210>  123
<211>  397
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of homo sapiens

<400>  123
atgggcacaa gcctgctgtg ttggatggcc ctgtgtctgc tgggagccga tcatgccgat       60

acgggagtgt ctcagaaccc cagacacaag atcaccaagc ggggccagaa cgtgaccttc      120

agatgcgacc ctatcagcga gcacaaccgg ctgtactggt acagacagac actcggccag      180

ggacctgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag cagactgctg      240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagaga      300

accgagcagg gcgacagcgc catgtatctg tgtgccagca gcctgaccac acctgacggc      360

tacacatttg gcagcggcac cagactgacc gtggtgg                               397


<210>  124
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human (codon optimized) with murinized constant region

<400>  124
atgaagacat ttgctggatt ttcgttcctg tttttgtggc tgcagctgga ctgtatgagt       60

agaggagagg atgtggagca gagtcttttc ctgagtgtcc gagagggaga cagctccgtt      120

ataaactgca cttacacaga cagctcctcc acctacttat actggtataa gcaagaacct      180

ggagcaggtc tccagttgct gacgtatatt ttttcaaata tggacatgaa acaagaccaa      240

agactcactg ttctattgaa taaaaaggat aaacatctgt ctctgcgcat tgcagacacc      300

cagactgggg actcagctat ctacttctgt gcagagaaat ggatcatctt tggaaaaggg      360

acacgacttc atattctccc caacatccag aatccggagc ccgccgtata ccagctgaag      420

gaccctagaa gccaggacag caccctgtgc ctgttcaccg acttcgacag ccagatcaac      480

gtgcccaaga ccatggaaag cggcaccttc atcaccgaca agacagtgct ggacatgaag      540

gccatggaca gcaagtccaa cggcgcaatc gcctggtcca accagaccag cttcacatgc      600

caggacatct tcaaagagac aaacgccaca taccccagca gcgacgtgcc ctgtgatgcc      660

accctgacag agaagtcctt cgagacagac atgaacctga acttccagaa tctgtccgtg      720

atgggcctga gaatcctgct gctgaaggtg gccggcttca atctgctgat gaccctgcgg      780

ctgtggtcca gctga                                                       795


<210>  125
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human (codon optimized) with murinized constant region

<400>  125
atgggcacaa gcctgctgtg ttggatggcc ctgtgtctgc tgggagccga tcatgccgat       60

acgggagtgt ctcagaaccc cagacacaag atcaccaagc ggggccagaa cgtgaccttc      120

agatgcgacc ctatcagcga gcacaaccgg ctgtactggt acagacagac actcggccag      180

ggacctgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag cagactgctg      240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagaga      300

accgagcagg gcgacagcgc catgtatctg tgtgccagca gcctgaccac acctgacggc      360

tacacatttg gcagcggcac cagactgacc gtggtggaag atctccggaa cgtgaccccc      420

cctaaagtga ccctgttcga acccagcaag gccgagatcg ccaacaagca gaaagccacc      480

ctcgtgtgcc tggccagagg cttcttcccc gaccatgtgg aactgtcttg gtgggtcaac      540

ggcaaagagg tgcacagcgg agtgtccacc gaccctcagg cctacaaaga gagcaactac      600

agctactgcc tgagcagcag actgcgggtg tccgccacct tctggcacaa cccccggaac      660

cacttcagat gccaggtgca gtttcacggc ctgagcgaag aggacaagtg gcccgaaggc      720

tcccccaagc ccgtgaccca gaatatctct gccgaggcct ggggcagagc cgactgtgga      780

attaccagcg ccagctacca ccagggcgtg ctgtctgcca ccatcctgta cgagatcctg      840

ctgggcaagg ccaccctgta cgccgtgctg gtgtctggcc tggtgctgat ggccatggtc      900

aagaagaaga acagctga                                                    918


<210>  126
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  126

Ala Arg Phe Ala Glu Gly Leu Glu Lys Leu Lys Glu Cys Val Leu His 
1               5                   10                  15      


Asp Asp Leu Leu Glu Ala Arg Arg Pro Arg Ala His Glu Cys Leu 
            20                  25                  30      


<210>  127
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  127

Asp Asp Leu Leu Glu 
1               5   


