                         SEQUENCE LISTING

<110>  UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
       EMORY UNIVERSITY
       EASLEY, CHARLES A. IV
       CHAN, ANTHONY W.S.
 
<120>  COMPOSITIONS AND METHODS FOR IMPROVING EMBRYO DEVELOPMENT

<130>  UGA 2018-017 PCT

<150>  62/713,182
<151>  2018-08-01

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  1660
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Ser Gly Pro Val Tyr His Gly Asp Ser Arg Gln Leu Ser Ala 
1               5                   10                  15      


Ser Gly Val Pro Val Asn Gly Ala Arg Glu Pro Ala Gly Pro Ser Leu 
            20                  25                  30          


Leu Gly Thr Gly Gly Pro Trp Arg Val Asp Gln Lys Pro Asp Trp Glu 
        35                  40                  45              


Ala Ala Pro Gly Pro Ala His Thr Ala Arg Leu Glu Asp Ala His Asp 
    50                  55                  60                  


Leu Val Ala Phe Ser Ala Val Ala Glu Ala Val Ser Ser Tyr Gly Ala 
65                  70                  75                  80  


Leu Ser Thr Arg Leu Tyr Glu Thr Phe Asn Arg Glu Met Ser Arg Glu 
                85                  90                  95      


Ala Gly Asn Asn Ser Arg Gly Pro Arg Pro Gly Pro Glu Gly Cys Ser 
            100                 105                 110         


Ala Gly Ser Glu Asp Leu Asp Thr Leu Gln Thr Ala Leu Ala Leu Ala 
        115                 120                 125             


Arg His Gly Met Lys Pro Pro Asn Cys Asn Cys Asp Gly Pro Glu Cys 
    130                 135                 140                 


Pro Asp Tyr Leu Glu Trp Leu Glu Gly Lys Ile Lys Ser Val Val Met 
145                 150                 155                 160 


Glu Gly Gly Glu Glu Arg Pro Arg Leu Pro Gly Pro Leu Pro Pro Gly 
                165                 170                 175     


Glu Ala Gly Leu Pro Ala Pro Ser Thr Arg Pro Leu Leu Ser Ser Glu 
            180                 185                 190         


Val Pro Gln Ile Ser Pro Gln Glu Gly Leu Pro Leu Ser Gln Ser Ala 
        195                 200                 205             


Leu Ser Ile Ala Lys Glu Lys Asn Ile Ser Leu Gln Thr Ala Ile Ala 
    210                 215                 220                 


Ile Glu Ala Leu Thr Gln Leu Ser Ser Ala Leu Pro Gln Pro Ser His 
225                 230                 235                 240 


Ser Thr Pro Gln Ala Ser Cys Pro Leu Pro Glu Ala Leu Ser Pro Pro 
                245                 250                 255     


Ala Pro Phe Arg Ser Pro Gln Ser Tyr Leu Arg Ala Pro Ser Trp Pro 
            260                 265                 270         


Val Val Pro Pro Glu Glu His Ser Ser Phe Ala Pro Asp Ser Ser Ala 
        275                 280                 285             


Phe Pro Pro Ala Thr Pro Arg Thr Glu Phe Pro Glu Ala Trp Gly Thr 
    290                 295                 300                 


Asp Thr Pro Pro Ala Thr Pro Arg Ser Ser Trp Pro Met Pro Arg Pro 
305                 310                 315                 320 


Ser Pro Asp Pro Met Ala Glu Leu Glu Gln Leu Leu Gly Ser Ala Ser 
                325                 330                 335     


Asp Tyr Ile Gln Ser Val Phe Lys Arg Pro Glu Ala Leu Pro Thr Lys 
            340                 345                 350         


Pro Lys Val Lys Val Glu Ala Pro Ser Ser Ser Pro Ala Pro Ala Pro 
        355                 360                 365             


Ser Pro Val Leu Gln Arg Glu Ala Pro Thr Pro Ser Ser Glu Pro Asp 
    370                 375                 380                 


Thr His Gln Lys Ala Gln Thr Ala Leu Gln Gln His Leu His His Lys 
385                 390                 395                 400 


Arg Ser Leu Phe Leu Glu Gln Val His Asp Thr Ser Phe Pro Ala Pro 
                405                 410                 415     


Ser Glu Pro Ser Ala Pro Gly Trp Trp Pro Pro Pro Ser Ser Pro Val 
            420                 425                 430         


Pro Arg Leu Pro Asp Arg Pro Pro Lys Glu Lys Lys Lys Lys Leu Pro 
        435                 440                 445             


Thr Pro Ala Gly Gly Pro Val Gly Thr Glu Lys Ala Ala Pro Gly Ile 
    450                 455                 460                 


Lys Pro Ser Val Arg Lys Pro Ile Gln Ile Lys Lys Ser Arg Pro Arg 
465                 470                 475                 480 


Glu Ala Gln Pro Leu Phe Pro Pro Val Arg Gln Ile Val Leu Glu Gly 
                485                 490                 495     


Leu Arg Ser Pro Ala Ser Gln Glu Val Gln Ala His Pro Pro Ala Pro 
            500                 505                 510         


Leu Pro Ala Ser Gln Gly Ser Ala Val Pro Leu Pro Pro Glu Pro Ser 
        515                 520                 525             


Leu Ala Leu Phe Ala Pro Ser Pro Ser Arg Asp Ser Leu Leu Pro Pro 
    530                 535                 540                 


Thr Gln Glu Met Arg Ser Pro Ser Pro Met Thr Ala Leu Gln Pro Gly 
545                 550                 555                 560 


Ser Thr Gly Pro Leu Pro Pro Ala Asp Asp Lys Leu Glu Glu Leu Ile 
                565                 570                 575     


Arg Gln Phe Glu Ala Glu Phe Gly Asp Ser Phe Gly Leu Pro Gly Pro 
            580                 585                 590         


Pro Ser Val Pro Ile Gln Asp Pro Glu Asn Gln Gln Thr Cys Leu Pro 
        595                 600                 605             


Ala Pro Glu Ser Pro Phe Ala Thr Arg Ser Pro Lys Gln Ile Lys Ile 
    610                 615                 620                 


Glu Ser Ser Gly Ala Val Thr Val Leu Ser Thr Thr Cys Phe His Ser 
625                 630                 635                 640 


Glu Glu Gly Gly Gln Glu Ala Thr Pro Thr Lys Ala Glu Asn Pro Leu 
                645                 650                 655     


Thr Pro Thr Leu Ser Gly Phe Leu Glu Ser Pro Leu Lys Tyr Leu Asp 
            660                 665                 670         


Thr Pro Thr Lys Ser Leu Leu Asp Thr Pro Ala Lys Arg Ala Gln Ala 
        675                 680                 685             


Glu Phe Pro Thr Cys Asp Cys Val Glu Gln Ile Val Glu Lys Asp Glu 
    690                 695                 700                 


Gly Pro Tyr Tyr Thr His Leu Gly Ser Gly Pro Thr Val Ala Ser Ile 
705                 710                 715                 720 


Arg Glu Leu Met Glu Glu Arg Tyr Gly Glu Lys Gly Lys Ala Ile Arg 
                725                 730                 735     


Ile Glu Lys Val Ile Tyr Thr Gly Lys Glu Gly Lys Ser Ser Arg Gly 
            740                 745                 750         


Cys Pro Ile Ala Lys Trp Val Ile Arg Arg His Thr Leu Glu Glu Lys 
        755                 760                 765             


Leu Leu Cys Leu Val Arg His Arg Ala Gly His His Cys Gln Asn Ala 
    770                 775                 780                 


Val Ile Val Ile Leu Ile Leu Ala Trp Glu Gly Ile Pro Arg Ser Leu 
785                 790                 795                 800 


Gly Asp Thr Leu Tyr Gln Glu Leu Thr Asp Thr Leu Arg Lys Tyr Gly 
                805                 810                 815     


Asn Pro Thr Ser Arg Arg Cys Gly Leu Asn Asp Asp Arg Thr Cys Ala 
            820                 825                 830         


Cys Gln Gly Lys Asp Pro Asn Thr Cys Gly Ala Ser Phe Ser Phe Gly 
        835                 840                 845             


Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys Tyr Ala Arg Ser Lys 
    850                 855                 860                 


Thr Pro Arg Lys Phe Arg Leu Ala Gly Asp Asn Pro Lys Glu Glu Glu 
865                 870                 875                 880 


Val Leu Arg Lys Ser Phe Gln Asp Leu Ala Thr Glu Val Ala Pro Leu 
                885                 890                 895     


Tyr Lys Arg Leu Ala Pro Gln Ala Tyr Gln Asn Gln Val Thr Asn Glu 
            900                 905                 910         


Glu Ile Ala Ile Asp Cys Arg Leu Gly Leu Lys Glu Gly Arg Pro Phe 
        915                 920                 925             


Ala Gly Val Thr Ala Cys Met Asp Phe Cys Ala His Ala His Lys Asp 
    930                 935                 940                 


Gln His Asn Leu Tyr Asn Gly Cys Thr Val Val Cys Thr Leu Thr Lys 
945                 950                 955                 960 


Glu Asp Asn Arg Cys Val Gly Lys Ile Pro Glu Asp Glu Gln Leu His 
                965                 970                 975     


Val Leu Pro Leu Tyr Lys Met Ala Asn Thr Asp Glu Phe Gly Ser Glu 
            980                 985                 990         


Glu Asn Gln Asn Ala Lys Val Gly  Ser Gly Ala Ile Gln  Val Leu Thr 
        995                 1000                 1005             


Ala Phe  Pro Arg Glu Val Arg  Arg Leu Pro Glu Pro  Ala Lys Ser 
    1010                 1015                 1020             


Cys Arg  Gln Arg Gln Leu Glu  Ala Arg Lys Ala Ala  Ala Glu Lys 
    1025                 1030                 1035             


Lys Lys  Ile Gln Lys Glu Lys  Leu Ser Thr Pro Glu  Lys Ile Lys 
    1040                 1045                 1050             


Gln Glu  Ala Leu Glu Leu Ala  Gly Ile Thr Ser Asp  Pro Gly Leu 
    1055                 1060                 1065             


Ser Leu  Lys Gly Gly Leu Ser  Gln Gln Gly Leu Lys  Pro Ser Leu 
    1070                 1075                 1080             


Lys Val  Glu Pro Gln Asn His  Phe Ser Ser Phe Lys  Tyr Ser Gly 
    1085                 1090                 1095             


Asn Ala  Val Val Glu Ser Tyr  Ser Val Leu Gly Asn  Cys Arg Pro 
    1100                 1105                 1110             


Ser Asp  Pro Tyr Ser Met Asn  Ser Val Tyr Ser Tyr  His Ser Tyr 
    1115                 1120                 1125             


Tyr Ala  Gln Pro Ser Leu Thr  Ser Val Asn Gly Phe  His Ser Lys 
    1130                 1135                 1140             


Tyr Ala  Leu Pro Ser Phe Ser  Tyr Tyr Gly Phe Pro  Ser Ser Asn 
    1145                 1150                 1155             


Pro Val  Phe Pro Ser Gln Phe  Leu Gly Pro Gly Ala  Trp Gly His 
    1160                 1165                 1170             


Ser Gly  Ser Ser Gly Ser Phe  Glu Lys Lys Pro Asp  Leu His Ala 
    1175                 1180                 1185             


Leu His  Asn Ser Leu Ser Pro  Ala Tyr Gly Gly Ala  Glu Phe Ala 
    1190                 1195                 1200             


Glu Leu  Pro Ser Gln Ala Val  Pro Thr Asp Ala His  His Pro Thr 
    1205                 1210                 1215             


Pro His  His Gln Gln Pro Ala  Tyr Pro Gly Pro Lys  Glu Tyr Leu 
    1220                 1225                 1230             


Leu Pro  Lys Ala Pro Leu Leu  His Ser Val Ser Arg  Asp Pro Ser 
    1235                 1240                 1245             


Pro Phe  Ala Gln Ser Ser Asn  Cys Tyr Asn Arg Ser  Ile Lys Gln 
    1250                 1255                 1260             


Glu Pro  Val Asp Pro Leu Thr  Gln Ala Glu Pro Val  Pro Arg Asp 
    1265                 1270                 1275             


Ala Gly  Lys Met Gly Lys Thr  Pro Leu Ser Glu Val  Ser Gln Asn 
    1280                 1285                 1290             


Gly Gly  Pro Ser His Leu Trp  Gly Gln Tyr Ser Gly  Gly Pro Ser 
    1295                 1300                 1305             


Met Ser  Pro Lys Arg Thr Asn  Gly Val Gly Gly Ser  Trp Gly Val 
    1310                 1315                 1320             


Phe Ser  Ser Gly Glu Ser Pro  Ala Ile Val Pro Asp  Lys Leu Ser 
    1325                 1330                 1335             


Ser Phe  Gly Ala Ser Cys Leu  Ala Pro Ser His Phe  Thr Asp Gly 
    1340                 1345                 1350             


Gln Trp  Gly Leu Phe Pro Gly  Glu Gly Gln Gln Ala  Ala Ser His 
    1355                 1360                 1365             


Ser Gly  Gly Arg Leu Arg Gly  Lys Pro Trp Ser Pro  Cys Lys Phe 
    1370                 1375                 1380             


Gly Asn  Ser Thr Ser Ala Leu  Ala Gly Pro Ser Leu  Thr Glu Lys 
    1385                 1390                 1395             


Pro Trp  Ala Leu Gly Ala Gly  Asp Phe Asn Ser Ala  Leu Lys Gly 
    1400                 1405                 1410             


Ser Pro  Gly Phe Gln Asp Lys  Leu Trp Asn Pro Met  Lys Gly Glu 
    1415                 1420                 1425             


Glu Gly  Arg Ile Pro Ala Ala  Gly Ala Ser Gln Leu  Asp Arg Ala 
    1430                 1435                 1440             


Trp Gln  Ser Phe Gly Leu Pro  Leu Gly Ser Ser Glu  Lys Leu Phe 
    1445                 1450                 1455             


Gly Ala  Leu Lys Ser Glu Glu  Lys Leu Trp Asp Pro  Phe Ser Leu 
    1460                 1465                 1470             


Glu Glu  Gly Pro Ala Glu Glu  Pro Pro Ser Lys Gly  Ala Val Lys 
    1475                 1480                 1485             


Glu Glu  Lys Gly Gly Gly Gly  Ala Glu Glu Glu Glu  Glu Glu Leu 
    1490                 1495                 1500             


Trp Ser  Asp Ser Glu His Asn  Phe Leu Asp Glu Asn  Ile Gly Gly 
    1505                 1510                 1515             


Val Ala  Val Ala Pro Ala His  Gly Ser Ile Leu Ile  Glu Cys Ala 
    1520                 1525                 1530             


Arg Arg  Glu Leu His Ala Thr  Thr Pro Leu Lys Lys  Pro Asn Arg 
    1535                 1540                 1545             


Cys His  Pro Thr Arg Ile Ser  Leu Val Phe Tyr Gln  His Lys Asn 
    1550                 1555                 1560             


Leu Asn  Gln Pro Asn His Gly  Leu Ala Leu Trp Glu  Ala Lys Met 
    1565                 1570                 1575             


Lys Gln  Leu Ala Glu Arg Ala  Arg Ala Arg Gln Glu  Glu Ala Ala 
    1580                 1585                 1590             


Arg Leu  Gly Leu Gly Gln Gln  Glu Ala Lys Leu Tyr  Gly Lys Lys 
    1595                 1600                 1605             


Arg Lys  Trp Gly Gly Thr Val  Val Ala Glu Pro Gln  Gln Lys Glu 
    1610                 1615                 1620             


Lys Lys  Gly Val Val Pro Thr  Arg Gln Ala Leu Ala  Val Pro Thr 
    1625                 1630                 1635             


Asp Ser  Ala Val Thr Val Ser  Ser Tyr Ala Tyr Thr  Lys Val Thr 
    1640                 1645                 1650             


Gly Pro  Tyr Ser Arg Trp Ile  
    1655                 1660 


<210>  2
<211>  5388
<212>  DNA
<213>  Homo sapiens

<400>  2
atgagccagt ttcaggtgcc cctggccgtc cagccggacc tgccaggcct ttatgacttc       60

cctcagcgcc aggtgatggt agggagcttc ccggggtctg ggctctccat ggctgggagt      120

gagtcccaac tccgaggggg tggagatggt cgaaagaaac ggaaacggtg tggtacttgt      180

gagccctgcc ggcggctgga aaactgtggc gcttgcacta gctgtaccaa ccgccgcacg      240

caccagatct gcaaactgcg aaaatgtgag gtgctgaaga aaaaagtagg gcttctcaag      300

gaggtggaaa taaaggctgg tgaaggagcc gggccgtggg gacaaggagc ggctgtcaag      360

acaggctcag agctcagccc agttgatgga cctgttccag gtcagatgga ctcagggcca      420

gtgtaccatg gggactcacg gcagctaagc gcctcagggg tgccggtcaa tggtgctaga      480

gagcccgctg gacccagtct gctggggact gggggtcctt ggcgggtaga ccaaaagccc      540

gactgggagg ctgccccagg cccagctcat actgctcgcc tggaagatgc ccacgatctg      600

gtggcctttt cggctgtggc cgaagctgtg tcctcttatg gggcccttag cacccggctc      660

tatgaaacct tcaaccgtga gatgagtcgt gaggctggga acaacagcag gggaccccgg      720

ccagggcctg agggctgctc tgctggcagc gaagaccttg acacactgca gacggccctg      780

gccctcgcgc ggcatggtat gaaaccaccc aactgcaact gcgatggccc agaatgccct      840

gactacctcg agtggctgga ggggaagatc aagtctgtgg tcatggaagg aggggaggag      900

cggcccaggc tcccagggcc tctgcctcct ggtgaggccg gcctcccagc accaagcacc      960

aggccactcc tcagctcaga ggtgccccag atctctcccc aagagggcct gcccctgtcc     1020

cagagtgccc tgagcattgc caaggaaaaa aacatcagct tgcagaccgc cattgccatt     1080

gaggccctca cacagctctc ctctgccctc ccgcagcctt ctcattccac cccccaggct     1140

tcttgccccc ttcctgaggc cttgtcacct cctgcccctt tcagatctcc ccagtcttac     1200

ctccgggctc cctcatggcc tgtggttcct cctgaagagc actcatcttt tgctcctgat     1260

agctctgcct tccctccagc aactcctaga actgagttcc ctgaagcctg gggcactgac     1320

acccctccag caacgccccg gagctcctgg cccatgcctc gcccaagccc cgatcccatg     1380

gctgaactgg agcagttgtt gggcagcgcc agtgattaca tccagtcagt attcaagcgg     1440

cctgaggccc tgcctaccaa gcccaaggtc aaggtggagg caccctcttc ctccccggcc     1500

ccggccccat cccctgtact tcagagggag gctcccacgc catcctcgga gcccgacacc     1560

caccagaagg cccagaccgc cctgcagcag cacctccacc acaagcgcag cctcttccta     1620

gaacaggtgc acgacacctc cttccctgct ccttcagagc cttctgctcc tggctggtgg     1680

cccccaccaa gttcacctgt cccacggctt ccagacagac cacccaagga gaagaagaag     1740

aagctcccaa caccagctgg aggtcccgtg ggaacggaga aagctgcccc tgggatcaag     1800

cccagtgtcc gaaagcccat tcagatcaag aagtccaggc cccgggaagc acagcccctc     1860

ttcccacctg tccgacagat tgtcctggaa gggcttaggt ccccagcctc ccaggaagtg     1920

caggctcatc caccggcccc tctgcctgcc tcacagggct ctgctgtgcc cctgccccca     1980

gaaccttctc ttgcgctatt tgcacctagt ccctccaggg acagcctgct gccccctact     2040

caggaaatga ggtcccccag ccccatgaca gccttgcagc caggctccac tggccctctt     2100

ccccctgccg atgacaagct ggaagagctc atccggcagt ttgaggctga atttggagat     2160

agctttgggc ttcccggccc cccttctgtg cccattcagg accccgagaa ccagcaaaca     2220

tgtctcccag cccctgagag cccctttgct acccgttccc ccaagcaaat caagattgag     2280

tcttcggggg ctgtgactgt gctctcaacc acctgcttcc attcagagga gggaggacag     2340

gaggccacac ccaccaaggc tgagaaccca ctcacaccca ccctcagtgg cttcttggag     2400

tcacctctta agtacctgga cacacccacc aagagtctgc tggacacacc tgccaagaga     2460

gcccaggccg agttccccac ctgcgattgc gtcgaacaaa tagtggagaa agatgaaggt     2520

ccatattata ctcacttggg atctggcccc acggtcgcct ctatccggga actcatggag     2580

gagcggtatg gagagaaggg gaaagccatc cggatcgaga aggtcatcta cacggggaag     2640

gagggaaaga gctcccgcgg ttgccccatt gcaaagtggg tgatccgcag gcacacgctg     2700

gaggagaagc tactctgcct ggtgcggcac cgggcaggcc accactgcca gaacgctgtg     2760

atcgtcatcc tcatcctggc ctgggagggc attccccgta gcctcggaga caccctctac     2820

caggagctca ccgacaccct ccggaagtat gggaacccca ccagccggag atgcggcctc     2880

aacgatgacc ggacctgcgc ttgccaaggc aaagacccca acacctgtgg tgcctccttc     2940

tcctttggtt gttcctggag catgtacttc aacggctgca agtatgctcg gagcaagaca     3000

cctcgcaagt tccgcctcgc aggggacaat cccaaagagg aagaagtgct ccggaagagt     3060

ttccaggacc tggccaccga agtcgctccc ctgtacaagc gactggcccc tcaggcctat     3120

cagaaccagg tgaccaacga ggaaatagcg attgactgcc gtctggggct gaaggaagga     3180

cggcccttcg cgggggtcac ggcctgcatg gacttctgtg cccacgccca caaggaccag     3240

cataacctct acaatgggtg caccgtggtc tgcaccctga ccaaggaaga caatcgctgc     3300

gtgggcaaga ttcccgagga tgagcagctg catgttctcc ccctgtacaa gatggccaac     3360

acggatgagt ttggtagcga ggagaaccag aatgcaaagg tgggcagcgg agccatccag     3420

gtgctcaccg ccttcccccg cgaggtccga cgcctgcccg agcctgccaa gtcctgccgc     3480

cagcggcagc tggaagccag aaaggcagca gccgagaaga agaagattca gaaggagaag     3540

ctgagcactc cggagaagat caagcaggag gccctggagc tggcgggcat tacgtcggac     3600

ccaggcctgt ctctgaaggg tggattgtcc cagcaaggcc tgaagccctc cctcaaggtg     3660

gagccgcaga accacttcag ctccttcaag tacagcggca acgcggtggt ggagagctac     3720

tcggtgctgg gcaactgccg gccctccgac ccttacagca tgaacagcgt gtactcctac     3780

cactcctact atgcacagcc cagcctgacc tccgtcaatg gcttccactc caagtacgct     3840

ctcccgtctt ttagctacta tggctttcca tccagcaacc ccgtcttccc ctctcagttc     3900

ctgggtcctg gtgcctgggg gcacagtggc agcagtggca gttttgagaa gaagccagac     3960

ctccacgctc tgcacaacag cctgagcccg gcctacggtg gtgctgagtt tgccgagctg     4020

cccagccagg ctgttcccac agacgcccac caccccactc ctcaccacca gcagcctgcg     4080

tacccaggcc ccaaggagta tctgcttccc aaggcccccc tactccactc agtgtccagg     4140

gacccctccc cctttgccca gagctccaac tgctacaaca gatccatcaa gcaagagcca     4200

gtagacccgc tgacccaggc tgagcctgtg cccagagacg ctggcaagat gggcaagaca     4260

cctctgtccg aggtgtctca gaatggagga cccagtcacc tttggggaca gtactcagga     4320

ggcccaagca tgtcccccaa gaggactaac ggtgtgggtg gcagctgggg tgtgttctcg     4380

tctggggaga gtcctgccat cgtccctgac aagctcagtt cctttggggc cagctgcctg     4440

gccccttccc acttcacaga tggccagtgg gggctgttcc ccggtgaggg gcagcaggca     4500

gcttcccact ctggaggacg gctgcgaggc aaaccgtgga gcccctgcaa gtttgggaac     4560

agcacctcgg ccttggctgg gcccagcctg actgagaagc cgtgggcgct gggggcaggg     4620

gatttcaact cggccctgaa aggtagtcct gggttccaag acaagctgtg gaaccccatg     4680

aaaggagagg agggcaggat tccagccgca ggggccagcc agctggacag ggcctggcag     4740

tcctttggtc tgcccctggg atccagcgag aagctgtttg gggctctgaa gtcagaggag     4800

aagctgtggg accccttcag cctggaggag gggccggctg aggagccccc cagcaaggga     4860

gcggtgaagg aggagaaggg cggtggtggt gcggaggagg aagaggagga gctgtggtcg     4920

gacagtgaac acaacttcct ggacgagaac atcggcggcg tggccgtggc cccagcccac     4980

ggctccatcc tcatcgagtg tgcccggcgg gagctgcacg ccaccacgcc gcttaagaag     5040

cccaaccgct gccaccccac ccgcatctcg ctggtcttct accagcacaa gaacctcaac     5100

cagcccaacc acgggctggc cctctgggaa gccaagatga agcagctggc ggagagggca     5160

cgggcacggc aggaggaggc tgcccggctg ggcctgggcc agcaggaggc caagctctac     5220

gggaagaagc gcaagtgggg gggcactgtg gttgctgagc cccagcagaa agagaagaag     5280

ggggtcgtcc ccacccggca ggcactggct gtgcccacag actcggcggt caccgtgtcc     5340

tcctatgcct acacgaaggt cactggcccc tacagccgct ggatctag                  5388


<210>  3
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  3

Met Ser Gln Phe Gln Val Pro Leu Ala Val Gln Pro Asp Leu Pro Gly 
1               5                   10                  15      


Leu Tyr Asp Phe Pro Gln Arg Gln Val Met Val Gly Ser Phe Pro Gly 
            20                  25                  30          


Ser Gly Leu Ser Met Ala Gly Ser Glu Ser Gln Leu Arg Gly Gly Gly 
        35                  40                  45              


Asp Gly Arg Lys Lys Arg Lys Arg Cys Gly Thr Cys Glu Pro Cys Arg 
    50                  55                  60                  


Arg Leu Glu Asn Cys Gly Ala Cys Thr Ser Cys Thr Asn Arg Arg Thr 
65                  70                  75                  80  


His Gln Ile Cys Lys Leu Arg Lys Cys Glu Val Leu Lys Lys Lys Val 
                85                  90                  95      


Gly Leu Leu Lys Glu Val Glu Ile Lys Ala Gly Glu Gly Ala Gly Pro 
            100                 105                 110         


Trp Gly Gln Gly Ala Ala Val Lys Thr Gly Ser Glu Leu Ser Pro Val 
        115                 120                 125             


Asp Gly Pro Val Pro Gly Gln Met 
    130                 135     


<210>  4
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  4
cctgcagaaa cgggaccacg aggg                                              24


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  5
cctgcagaaa cgggaccatg aggg                                              24


<210>  6
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is a, c, g, or t

<400>  6
gctgcagaaa cgggaccacg ngg                                               23


<210>  7
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  7
cctgcagaaa cgggaccatg agggctttgg ttttg                                  35


<210>  8
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  8
cctgcagaaa cgggaccatt ttggttttg                                         29


<210>  9
<211>  2002
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Gln Asp Arg Thr Asn His Val Glu Gly Asn Arg Leu Ser Pro 
1               5                   10                  15      


Phe Leu Ile Pro Ser Pro Pro Ile Cys Gln Thr Glu Pro Leu Ala Thr 
            20                  25                  30          


Lys Leu Gln Asn Gly Ser Pro Leu Pro Glu Arg Ala His Pro Glu Val 
        35                  40                  45              


Asn Gly Asp Thr Lys Trp His Ser Phe Lys Ser Tyr Tyr Gly Ile Pro 
    50                  55                  60                  


Cys Met Lys Gly Ser Gln Asn Ser Arg Val Ser Pro Asp Phe Thr Gln 
65                  70                  75                  80  


Glu Ser Arg Gly Tyr Ser Lys Cys Leu Gln Asn Gly Gly Ile Lys Arg 
                85                  90                  95      


Thr Val Ser Glu Pro Ser Leu Ser Gly Leu Leu Gln Ile Lys Lys Leu 
            100                 105                 110         


Lys Gln Asp Gln Lys Ala Asn Gly Glu Arg Arg Asn Phe Gly Val Ser 
        115                 120                 125             


Gln Glu Arg Asn Pro Gly Glu Ser Ser Gln Pro Asn Val Ser Asp Leu 
    130                 135                 140                 


Ser Asp Lys Lys Glu Ser Val Ser Ser Val Ala Gln Glu Asn Ala Val 
145                 150                 155                 160 


Lys Asp Phe Thr Ser Phe Ser Thr His Asn Cys Ser Gly Pro Glu Asn 
                165                 170                 175     


Pro Glu Leu Gln Ile Leu Asn Glu Gln Glu Gly Lys Ser Ala Asn Tyr 
            180                 185                 190         


His Asp Lys Asn Ile Val Leu Leu Lys Asn Lys Ala Val Leu Met Pro 
        195                 200                 205             


Asn Gly Ala Thr Val Ser Ala Ser Ser Val Glu His Thr His Gly Glu 
    210                 215                 220                 


Leu Leu Glu Lys Thr Leu Ser Gln Tyr Tyr Pro Asp Cys Val Ser Ile 
225                 230                 235                 240 


Ala Val Gln Lys Thr Thr Ser His Ile Asn Ala Ile Asn Ser Gln Ala 
                245                 250                 255     


Thr Asn Glu Leu Ser Cys Glu Ile Thr His Pro Ser His Thr Ser Gly 
            260                 265                 270         


Gln Ile Asn Ser Ala Gln Thr Ser Asn Ser Glu Leu Pro Pro Lys Pro 
        275                 280                 285             


Ala Ala Val Val Ser Glu Ala Cys Asp Ala Asp Asp Ala Asp Asn Ala 
    290                 295                 300                 


Ser Lys Leu Ala Ala Met Leu Asn Thr Cys Ser Phe Gln Lys Pro Glu 
305                 310                 315                 320 


Gln Leu Gln Gln Gln Lys Ser Val Phe Glu Ile Cys Pro Ser Pro Ala 
                325                 330                 335     


Glu Asn Asn Ile Gln Gly Thr Thr Lys Leu Ala Ser Gly Glu Glu Phe 
            340                 345                 350         


Cys Ser Gly Ser Ser Ser Asn Leu Gln Ala Pro Gly Gly Ser Ser Glu 
        355                 360                 365             


Arg Tyr Leu Lys Gln Asn Glu Met Asn Gly Ala Tyr Phe Lys Gln Ser 
    370                 375                 380                 


Ser Val Phe Thr Lys Asp Ser Phe Ser Ala Thr Thr Thr Pro Pro Pro 
385                 390                 395                 400 


Pro Ser Gln Leu Leu Leu Ser Pro Pro Pro Pro Leu Pro Gln Val Pro 
                405                 410                 415     


Gln Leu Pro Ser Glu Gly Lys Ser Thr Leu Asn Gly Gly Val Leu Glu 
            420                 425                 430         


Glu His His His Tyr Pro Asn Gln Ser Asn Thr Thr Leu Leu Arg Glu 
        435                 440                 445             


Val Lys Ile Glu Gly Lys Pro Glu Ala Pro Pro Ser Gln Ser Pro Asn 
    450                 455                 460                 


Pro Ser Thr His Val Cys Ser Pro Ser Pro Met Leu Ser Glu Arg Pro 
465                 470                 475                 480 


Gln Asn Asn Cys Val Asn Arg Asn Asp Ile Gln Thr Ala Gly Thr Met 
                485                 490                 495     


Thr Val Pro Leu Cys Ser Glu Lys Thr Arg Pro Met Ser Glu His Leu 
            500                 505                 510         


Lys His Asn Pro Pro Ile Phe Gly Ser Ser Gly Glu Leu Gln Asp Asn 
        515                 520                 525             


Cys Gln Gln Leu Met Arg Asn Lys Glu Gln Glu Ile Leu Lys Gly Arg 
    530                 535                 540                 


Asp Lys Glu Gln Thr Arg Asp Leu Val Pro Pro Thr Gln His Tyr Leu 
545                 550                 555                 560 


Lys Pro Gly Trp Ile Glu Leu Lys Ala Pro Arg Phe His Gln Ala Glu 
                565                 570                 575     


Ser His Leu Lys Arg Asn Glu Ala Ser Leu Pro Ser Ile Leu Gln Tyr 
            580                 585                 590         


Gln Pro Asn Leu Ser Asn Gln Met Thr Ser Lys Gln Tyr Thr Gly Asn 
        595                 600                 605             


Ser Asn Met Pro Gly Gly Leu Pro Arg Gln Ala Tyr Thr Gln Lys Thr 
    610                 615                 620                 


Thr Gln Leu Glu His Lys Ser Gln Met Tyr Gln Val Glu Met Asn Gln 
625                 630                 635                 640 


Gly Gln Ser Gln Gly Thr Val Asp Gln His Leu Gln Phe Gln Lys Pro 
                645                 650                 655     


Ser His Gln Val His Phe Ser Lys Thr Asp His Leu Pro Lys Ala His 
            660                 665                 670         


Val Gln Ser Leu Cys Gly Thr Arg Phe His Phe Gln Gln Arg Ala Asp 
        675                 680                 685             


Ser Gln Thr Glu Lys Leu Met Ser Pro Val Leu Lys Gln His Leu Asn 
    690                 695                 700                 


Gln Gln Ala Ser Glu Thr Glu Pro Phe Ser Asn Ser His Leu Leu Gln 
705                 710                 715                 720 


His Lys Pro His Lys Gln Ala Ala Gln Thr Gln Pro Ser Gln Ser Ser 
                725                 730                 735     


His Leu Pro Gln Asn Gln Gln Gln Gln Gln Lys Leu Gln Ile Lys Asn 
            740                 745                 750         


Lys Glu Glu Ile Leu Gln Thr Phe Pro His Pro Gln Ser Asn Asn Asp 
        755                 760                 765             


Gln Gln Arg Glu Gly Ser Phe Phe Gly Gln Thr Lys Val Glu Glu Cys 
    770                 775                 780                 


Phe His Gly Glu Asn Gln Tyr Ser Lys Ser Ser Glu Phe Glu Thr His 
785                 790                 795                 800 


Asn Val Gln Met Gly Leu Glu Glu Val Gln Asn Ile Asn Arg Arg Asn 
                805                 810                 815     


Ser Pro Tyr Ser Gln Thr Met Lys Ser Ser Ala Cys Lys Ile Gln Val 
            820                 825                 830         


Ser Cys Ser Asn Asn Thr His Leu Val Ser Glu Asn Lys Glu Gln Thr 
        835                 840                 845             


Thr His Pro Glu Leu Phe Ala Gly Asn Lys Thr Gln Asn Leu His His 
    850                 855                 860                 


Met Gln Tyr Phe Pro Asn Asn Val Ile Pro Lys Gln Asp Leu Leu His 
865                 870                 875                 880 


Arg Cys Phe Gln Glu Gln Glu Gln Lys Ser Gln Gln Ala Ser Val Leu 
                885                 890                 895     


Gln Gly Tyr Lys Asn Arg Asn Gln Asp Met Ser Gly Gln Gln Ala Ala 
            900                 905                 910         


Gln Leu Ala Gln Gln Arg Tyr Leu Ile His Asn His Ala Asn Val Phe 
        915                 920                 925             


Pro Val Pro Asp Gln Gly Gly Ser His Thr Gln Thr Pro Pro Gln Lys 
    930                 935                 940                 


Asp Thr Gln Lys His Ala Ala Leu Arg Trp His Leu Leu Gln Lys Gln 
945                 950                 955                 960 


Glu Gln Gln Gln Thr Gln Gln Pro Gln Thr Glu Ser Cys His Ser Gln 
                965                 970                 975     


Met His Arg Pro Ile Lys Val Glu Pro Gly Cys Lys Pro His Ala Cys 
            980                 985                 990         


Met His Thr Ala Pro Pro Glu Asn  Lys Thr Trp Lys Lys  Val Thr Lys 
        995                 1000                 1005             


Gln Glu  Asn Pro Pro Ala Ser  Cys Asp Asn Val Gln  Gln Lys Ser 
    1010                 1015                 1020             


Ile Ile  Glu Thr Met Glu Gln  His Leu Lys Gln Phe  His Ala Lys 
    1025                 1030                 1035             


Ser Leu  Phe Asp His Lys Ala  Leu Thr Leu Lys Ser  Gln Lys Gln 
    1040                 1045                 1050             


Val Lys  Val Glu Met Ser Gly  Pro Val Thr Val Leu  Thr Arg Gln 
    1055                 1060                 1065             


Thr Thr  Ala Ala Glu Leu Asp  Ser His Thr Pro Ala  Leu Glu Gln 
    1070                 1075                 1080             


Gln Thr  Thr Ser Ser Glu Lys  Thr Pro Thr Lys Arg  Thr Ala Ala 
    1085                 1090                 1095             


Ser Val  Leu Asn Asn Phe Ile  Glu Ser Pro Ser Lys  Leu Leu Asp 
    1100                 1105                 1110             


Thr Pro  Ile Lys Asn Leu Leu  Asp Thr Pro Val Lys  Thr Gln Tyr 
    1115                 1120                 1125             


Asp Phe  Pro Ser Cys Arg Cys  Val Glu Gln Ile Ile  Glu Lys Asp 
    1130                 1135                 1140             


Glu Gly  Pro Phe Tyr Thr His  Leu Gly Ala Gly Pro  Asn Val Ala 
    1145                 1150                 1155             


Ala Ile  Arg Glu Ile Met Glu  Glu Arg Phe Gly Gln  Lys Gly Lys 
    1160                 1165                 1170             


Ala Ile  Arg Ile Glu Arg Val  Ile Tyr Thr Gly Lys  Glu Gly Lys 
    1175                 1180                 1185             


Ser Ser  Gln Gly Cys Pro Ile  Ala Lys Trp Val Val  Arg Arg Ser 
    1190                 1195                 1200             


Ser Ser  Glu Glu Lys Leu Leu  Cys Leu Val Arg Glu  Arg Ala Gly 
    1205                 1210                 1215             


His Thr  Cys Glu Ala Ala Val  Ile Val Ile Leu Ile  Leu Val Trp 
    1220                 1225                 1230             


Glu Gly  Ile Pro Leu Ser Leu  Ala Asp Lys Leu Tyr  Ser Glu Leu 
    1235                 1240                 1245             


Thr Glu  Thr Leu Arg Lys Tyr  Gly Thr Leu Thr Asn  Arg Arg Cys 
    1250                 1255                 1260             


Ala Leu  Asn Glu Glu Arg Thr  Cys Ala Cys Gln Gly  Leu Asp Pro 
    1265                 1270                 1275             


Glu Thr  Cys Gly Ala Ser Phe  Ser Phe Gly Cys Ser  Trp Ser Met 
    1280                 1285                 1290             


Tyr Tyr  Asn Gly Cys Lys Phe  Ala Arg Ser Lys Ile  Pro Arg Lys 
    1295                 1300                 1305             


Phe Lys  Leu Leu Gly Asp Asp  Pro Lys Glu Glu Glu  Lys Leu Glu 
    1310                 1315                 1320             


Ser His  Leu Gln Asn Leu Ser  Thr Leu Met Ala Pro  Thr Tyr Lys 
    1325                 1330                 1335             


Lys Leu  Ala Pro Asp Ala Tyr  Asn Asn Gln Ile Glu  Tyr Glu His 
    1340                 1345                 1350             


Arg Ala  Pro Glu Cys Arg Leu  Gly Leu Lys Glu Gly  Arg Pro Phe 
    1355                 1360                 1365             


Ser Gly  Val Thr Ala Cys Leu  Asp Phe Cys Ala His  Ala His Arg 
    1370                 1375                 1380             


Asp Leu  His Asn Met Gln Asn  Gly Ser Thr Leu Val  Cys Thr Leu 
    1385                 1390                 1395             


Thr Arg  Glu Asp Asn Arg Glu  Phe Gly Gly Lys Pro  Glu Asp Glu 
    1400                 1405                 1410             


Gln Leu  His Val Leu Pro Leu  Tyr Lys Val Ser Asp  Val Asp Glu 
    1415                 1420                 1425             


Phe Gly  Ser Val Glu Ala Gln  Glu Glu Lys Lys Arg  Ser Gly Ala 
    1430                 1435                 1440             


Ile Gln  Val Leu Ser Ser Phe  Arg Arg Lys Val Arg  Met Leu Ala 
    1445                 1450                 1455             


Glu Pro  Val Lys Thr Cys Arg  Gln Arg Lys Leu Glu  Ala Lys Lys 
    1460                 1465                 1470             


Ala Ala  Ala Glu Lys Leu Ser  Ser Leu Glu Asn Ser  Ser Asn Lys 
    1475                 1480                 1485             


Asn Glu  Lys Glu Lys Ser Ala  Pro Ser Arg Thr Lys  Gln Thr Glu 
    1490                 1495                 1500             


Asn Ala  Ser Gln Ala Lys Gln  Leu Ala Glu Leu Leu  Arg Leu Ser 
    1505                 1510                 1515             


Gly Pro  Val Met Gln Gln Ser  Gln Gln Pro Gln Pro  Leu Gln Lys 
    1520                 1525                 1530             


Gln Pro  Pro Gln Pro Gln Gln  Gln Gln Arg Pro Gln  Gln Gln Gln 
    1535                 1540                 1545             


Pro His  His Pro Gln Thr Glu  Ser Val Asn Ser Tyr  Ser Ala Ser 
    1550                 1555                 1560             


Gly Ser  Thr Asn Pro Tyr Met  Arg Arg Pro Asn Pro  Val Ser Pro 
    1565                 1570                 1575             


Tyr Pro  Asn Ser Ser His Thr  Ser Asp Ile Tyr Gly  Ser Thr Ser 
    1580                 1585                 1590             


Pro Met  Asn Phe Tyr Ser Thr  Ser Ser Gln Ala Ala  Gly Ser Tyr 
    1595                 1600                 1605             


Leu Asn  Ser Ser Asn Pro Met  Asn Pro Tyr Pro Gly  Leu Leu Asn 
    1610                 1615                 1620             


Gln Asn  Thr Gln Tyr Pro Ser  Tyr Gln Cys Asn Gly  Asn Leu Ser 
    1625                 1630                 1635             


Val Asp  Asn Cys Ser Pro Tyr  Leu Gly Ser Tyr Ser  Pro Gln Ser 
    1640                 1645                 1650             


Gln Pro  Met Asp Leu Tyr Arg  Tyr Pro Ser Gln Asp  Pro Leu Ser 
    1655                 1660                 1665             


Lys Leu  Ser Leu Pro Pro Ile  His Thr Leu Tyr Gln  Pro Arg Phe 
    1670                 1675                 1680             


Gly Asn  Ser Gln Ser Phe Thr  Ser Lys Tyr Leu Gly  Tyr Gly Asn 
    1685                 1690                 1695             


Gln Asn  Met Gln Gly Asp Gly  Phe Ser Ser Cys Thr  Ile Arg Pro 
    1700                 1705                 1710             


Asn Val  His His Val Gly Lys  Leu Pro Pro Tyr Pro  Thr His Glu 
    1715                 1720                 1725             


Met Asp  Gly His Phe Met Gly  Ala Thr Ser Arg Leu  Pro Pro Asn 
    1730                 1735                 1740             


Leu Ser  Asn Pro Asn Met Asp  Tyr Lys Asn Gly Glu  His His Ser 
    1745                 1750                 1755             


Pro Ser  His Ile Ile His Asn  Tyr Ser Ala Ala Pro  Gly Met Phe 
    1760                 1765                 1770             


Asn Ser  Ser Leu His Ala Leu  His Leu Gln Asn Lys  Glu Asn Asp 
    1775                 1780                 1785             


Met Leu  Ser His Thr Ala Asn  Gly Leu Ser Lys Met  Leu Pro Ala 
    1790                 1795                 1800             


Leu Asn  His Asp Arg Thr Ala  Cys Val Gln Gly Gly  Leu His Lys 
    1805                 1810                 1815             


Leu Ser  Asp Ala Asn Gly Gln  Glu Lys Gln Pro Leu  Ala Leu Val 
    1820                 1825                 1830             


Gln Gly  Val Ala Ser Gly Ala  Glu Asp Asn Asp Glu  Val Trp Ser 
    1835                 1840                 1845             


Asp Ser  Glu Gln Ser Phe Leu  Asp Pro Asp Ile Gly  Gly Val Ala 
    1850                 1855                 1860             


Val Ala  Pro Thr His Gly Ser  Ile Leu Ile Glu Cys  Ala Lys Arg 
    1865                 1870                 1875             


Glu Leu  His Ala Thr Thr Pro  Leu Lys Asn Pro Asn  Arg Asn His 
    1880                 1885                 1890             


Pro Thr  Arg Ile Ser Leu Val  Phe Tyr Gln His Lys  Ser Met Asn 
    1895                 1900                 1905             


Glu Pro  Lys His Gly Leu Ala  Leu Trp Glu Ala Lys  Met Ala Glu 
    1910                 1915                 1920             


Lys Ala  Arg Glu Lys Glu Glu  Glu Cys Glu Lys Tyr  Gly Pro Asp 
    1925                 1930                 1935             


Tyr Val  Pro Gln Lys Ser His  Gly Lys Lys Val Lys  Arg Glu Pro 
    1940                 1945                 1950             


Ala Glu  Pro His Glu Thr Ser  Glu Pro Thr Tyr Leu  Arg Phe Ile 
    1955                 1960                 1965             


Lys Ser  Leu Ala Glu Arg Thr  Met Ser Val Thr Thr  Asp Ser Thr 
    1970                 1975                 1980             


Val Thr  Thr Ser Pro Tyr Ala  Phe Thr Arg Val Thr  Gly Pro Tyr 
    1985                 1990                 1995             


Asn Arg  Tyr Ile 
    2000         


<210>  10
<211>  2136
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Arg Ser Arg His Ala Arg Pro Ser Arg Leu Val Arg Lys Glu 
1               5                   10                  15      


Asp Val Asn Lys Lys Lys Lys Asn Ser Gln Leu Arg Lys Thr Thr Lys 
            20                  25                  30          


Gly Ala Asn Lys Asn Val Ala Ser Val Lys Thr Leu Ser Pro Gly Lys 
        35                  40                  45              


Leu Lys Gln Leu Ile Gln Glu Arg Asp Val Lys Lys Lys Thr Glu Pro 
    50                  55                  60                  


Lys Pro Pro Val Pro Val Arg Ser Leu Leu Thr Arg Ala Gly Ala Ala 
65                  70                  75                  80  


Arg Met Asn Leu Asp Arg Thr Glu Val Leu Phe Gln Asn Pro Glu Ser 
                85                  90                  95      


Leu Thr Cys Asn Gly Phe Thr Met Ala Leu Arg Ser Thr Ser Leu Ser 
            100                 105                 110         


Arg Arg Leu Ser Gln Pro Pro Leu Val Val Ala Lys Ser Lys Lys Val 
        115                 120                 125             


Pro Leu Ser Lys Gly Leu Glu Lys Gln His Asp Cys Asp Tyr Lys Ile 
    130                 135                 140                 


Leu Pro Ala Leu Gly Val Lys His Ser Glu Asn Asp Ser Val Pro Met 
145                 150                 155                 160 


Gln Asp Thr Gln Val Leu Pro Asp Ile Glu Thr Leu Ile Gly Val Gln 
                165                 170                 175     


Asn Pro Ser Leu Leu Lys Gly Lys Ser Gln Glu Thr Thr Gln Phe Trp 
            180                 185                 190         


Ser Gln Arg Val Glu Asp Ser Lys Ile Asn Ile Pro Thr His Ser Gly 
        195                 200                 205             


Pro Ala Ala Glu Ile Leu Pro Gly Pro Leu Glu Gly Thr Arg Cys Gly 
    210                 215                 220                 


Glu Gly Leu Phe Ser Glu Glu Thr Leu Asn Asp Thr Ser Gly Ser Pro 
225                 230                 235                 240 


Lys Met Phe Ala Gln Asp Thr Val Cys Ala Pro Phe Pro Gln Arg Ala 
                245                 250                 255     


Thr Pro Lys Val Thr Ser Gln Gly Asn Pro Ser Ile Gln Leu Glu Glu 
            260                 265                 270         


Leu Gly Ser Arg Val Glu Ser Leu Lys Leu Ser Asp Ser Tyr Leu Asp 
        275                 280                 285             


Pro Ile Lys Ser Glu His Asp Cys Tyr Pro Thr Ser Ser Leu Asn Lys 
    290                 295                 300                 


Val Ile Pro Asp Leu Asn Leu Arg Asn Cys Leu Ala Leu Gly Gly Ser 
305                 310                 315                 320 


Thr Ser Pro Thr Ser Val Ile Lys Phe Leu Leu Ala Gly Ser Lys Gln 
                325                 330                 335     


Ala Thr Leu Gly Ala Lys Pro Asp His Gln Glu Ala Phe Glu Ala Thr 
            340                 345                 350         


Ala Asn Gln Gln Glu Val Ser Asp Thr Thr Ser Phe Leu Gly Gln Ala 
        355                 360                 365             


Phe Gly Ala Ile Pro His Gln Trp Glu Leu Pro Gly Ala Asp Pro Val 
    370                 375                 380                 


His Gly Glu Ala Leu Gly Glu Thr Pro Asp Leu Pro Glu Ile Pro Gly 
385                 390                 395                 400 


Ala Ile Pro Val Gln Gly Glu Val Phe Gly Thr Ile Leu Asp Gln Gln 
                405                 410                 415     


Glu Thr Leu Gly Met Ser Gly Ser Val Val Pro Asp Leu Pro Val Phe 
            420                 425                 430         


Leu Pro Val Pro Pro Asn Pro Ile Ala Thr Phe Asn Ala Pro Ser Lys 
        435                 440                 445             


Trp Pro Glu Pro Gln Ser Thr Val Ser Tyr Gly Leu Ala Val Gln Gly 
    450                 455                 460                 


Ala Ile Gln Ile Leu Pro Leu Gly Ser Gly His Thr Pro Gln Ser Ser 
465                 470                 475                 480 


Ser Asn Ser Glu Lys Asn Ser Leu Pro Pro Val Met Ala Ile Ser Asn 
                485                 490                 495     


Val Glu Asn Glu Lys Gln Val His Ile Ser Phe Leu Pro Ala Asn Thr 
            500                 505                 510         


Gln Gly Phe Pro Leu Ala Pro Glu Arg Gly Leu Phe His Ala Ser Leu 
        515                 520                 525             


Gly Ile Ala Gln Leu Ser Gln Ala Gly Pro Ser Lys Ser Asp Arg Gly 
    530                 535                 540                 


Ser Ser Gln Val Ser Val Thr Ser Thr Val His Val Val Asn Thr Thr 
545                 550                 555                 560 


Val Val Thr Met Pro Val Pro Met Val Ser Thr Ser Ser Ser Ser Tyr 
                565                 570                 575     


Thr Thr Leu Leu Pro Thr Leu Glu Lys Lys Lys Arg Lys Arg Cys Gly 
            580                 585                 590         


Val Cys Glu Pro Cys Gln Gln Lys Thr Asn Cys Gly Glu Cys Thr Tyr 
        595                 600                 605             


Cys Lys Asn Arg Lys Asn Ser His Gln Ile Cys Lys Lys Arg Lys Cys 
    610                 615                 620                 


Glu Glu Leu Lys Lys Lys Pro Ser Val Val Val Pro Leu Glu Val Ile 
625                 630                 635                 640 


Lys Glu Asn Lys Arg Pro Gln Arg Glu Lys Lys Pro Lys Val Leu Lys 
                645                 650                 655     


Ala Asp Phe Asp Asn Lys Pro Val Asn Gly Pro Lys Ser Glu Ser Met 
            660                 665                 670         


Asp Tyr Ser Arg Cys Gly His Gly Glu Glu Gln Lys Leu Glu Leu Asn 
        675                 680                 685             


Pro His Thr Val Glu Asn Val Thr Lys Asn Glu Asp Ser Met Thr Gly 
    690                 695                 700                 


Ile Glu Val Glu Lys Trp Thr Gln Asn Lys Lys Ser Gln Leu Thr Asp 
705                 710                 715                 720 


His Val Lys Gly Asp Phe Ser Ala Asn Val Pro Glu Ala Glu Lys Ser 
                725                 730                 735     


Lys Asn Ser Glu Val Asp Lys Lys Arg Thr Lys Ser Pro Lys Leu Phe 
            740                 745                 750         


Val Gln Thr Val Arg Asn Gly Ile Lys His Val His Cys Leu Pro Ala 
        755                 760                 765             


Glu Thr Asn Val Ser Phe Lys Lys Phe Asn Ile Glu Glu Phe Gly Lys 
    770                 775                 780                 


Thr Leu Glu Asn Asn Ser Tyr Lys Phe Leu Lys Asp Thr Ala Asn His 
785                 790                 795                 800 


Lys Asn Ala Met Ser Ser Val Ala Thr Asp Met Ser Cys Asp His Leu 
                805                 810                 815     


Lys Gly Arg Ser Asn Val Leu Val Phe Gln Gln Pro Gly Phe Asn Cys 
            820                 825                 830         


Ser Ser Ile Pro His Ser Ser His Ser Ile Ile Asn His His Ala Ser 
        835                 840                 845             


Ile His Asn Glu Gly Asp Gln Pro Lys Thr Pro Glu Asn Ile Pro Ser 
    850                 855                 860                 


Lys Glu Pro Lys Asp Gly Ser Pro Val Gln Pro Ser Leu Leu Ser Leu 
865                 870                 875                 880 


Met Lys Asp Arg Arg Leu Thr Leu Glu Gln Val Val Ala Ile Glu Ala 
                885                 890                 895     


Leu Thr Gln Leu Ser Glu Ala Pro Ser Glu Asn Ser Ser Pro Ser Lys 
            900                 905                 910         


Ser Glu Lys Asp Glu Glu Ser Glu Gln Arg Thr Ala Ser Leu Leu Asn 
        915                 920                 925             


Ser Cys Lys Ala Ile Leu Tyr Thr Val Arg Lys Asp Leu Gln Asp Pro 
    930                 935                 940                 


Asn Leu Gln Gly Glu Pro Pro Lys Leu Asn His Cys Pro Ser Leu Glu 
945                 950                 955                 960 


Lys Gln Ser Ser Cys Asn Thr Val Val Phe Asn Gly Gln Thr Thr Thr 
                965                 970                 975     


Leu Ser Asn Ser His Ile Asn Ser Ala Thr Asn Gln Ala Ser Thr Lys 
            980                 985                 990         


Ser His Glu Tyr Ser Lys Val Thr  Asn Ser Leu Ser Leu  Phe Ile Pro 
        995                 1000                 1005             


Lys Ser  Asn Ser Ser Lys Ile  Asp Thr Asn Lys Ser  Ile Ala Gln 
    1010                 1015                 1020             


Gly Ile  Ile Thr Leu Asp Asn  Cys Ser Asn Asp Leu  His Gln Leu 
    1025                 1030                 1035             


Pro Pro  Arg Asn Asn Glu Val  Glu Tyr Cys Asn Gln  Leu Leu Asp 
    1040                 1045                 1050             


Ser Ser  Lys Lys Leu Asp Ser  Asp Asp Leu Ser Cys  Gln Asp Ala 
    1055                 1060                 1065             


Thr His  Thr Gln Ile Glu Glu  Asp Val Ala Thr Gln  Leu Thr Gln 
    1070                 1075                 1080             


Leu Ala  Ser Ile Ile Lys Ile  Asn Tyr Ile Lys Pro  Glu Asp Lys 
    1085                 1090                 1095             


Lys Val  Glu Ser Thr Pro Thr  Ser Leu Val Thr Cys  Asn Val Gln 
    1100                 1105                 1110             


Gln Lys  Tyr Asn Gln Glu Lys  Gly Thr Ile Gln Gln  Lys Pro Pro 
    1115                 1120                 1125             


Ser Ser  Val His Asn Asn His  Gly Ser Ser Leu Thr  Lys Gln Lys 
    1130                 1135                 1140             


Asn Pro  Thr Gln Lys Lys Thr  Lys Ser Thr Pro Ser  Arg Asp Arg 
    1145                 1150                 1155             


Arg Lys  Lys Lys Pro Thr Val  Val Ser Tyr Gln Glu  Asn Asp Arg 
    1160                 1165                 1170             


Gln Lys  Trp Glu Lys Leu Ser  Tyr Met Tyr Gly Thr  Ile Cys Asp 
    1175                 1180                 1185             


Ile Trp  Ile Ala Ser Lys Phe  Gln Asn Phe Gly Gln  Phe Cys Pro 
    1190                 1195                 1200             


His Asp  Phe Pro Thr Val Phe  Gly Lys Ile Ser Ser  Ser Thr Lys 
    1205                 1210                 1215             


Ile Trp  Lys Pro Leu Ala Gln  Thr Arg Ser Ile Met  Gln Pro Lys 
    1220                 1225                 1230             


Thr Val  Phe Pro Pro Leu Thr  Gln Ile Lys Leu Gln  Arg Tyr Pro 
    1235                 1240                 1245             


Glu Ser  Ala Glu Glu Lys Val  Lys Val Glu Pro Leu  Asp Ser Leu 
    1250                 1255                 1260             


Ser Leu  Phe His Leu Lys Thr  Glu Ser Asn Gly Lys  Ala Phe Thr 
    1265                 1270                 1275             


Asp Lys  Ala Tyr Asn Ser Gln  Val Gln Leu Thr Val  Asn Ala Asn 
    1280                 1285                 1290             


Gln Lys  Ala His Pro Leu Thr  Gln Pro Ser Ser Pro  Pro Asn Gln 
    1295                 1300                 1305             


Cys Ala  Asn Val Met Ala Gly  Asp Asp Gln Ile Arg  Phe Gln Gln 
    1310                 1315                 1320             


Val Val  Lys Glu Gln Leu Met  His Gln Arg Leu Pro  Thr Leu Pro 
    1325                 1330                 1335             


Gly Ile  Ser His Glu Thr Pro  Leu Pro Glu Ser Ala  Leu Thr Leu 
    1340                 1345                 1350             


Arg Asn  Val Asn Val Val Cys  Ser Gly Gly Ile Thr  Val Val Ser 
    1355                 1360                 1365             


Thr Lys  Ser Glu Glu Glu Val  Cys Ser Ser Ser Phe  Gly Thr Ser 
    1370                 1375                 1380             


Glu Phe  Ser Thr Val Asp Ser  Ala Gln Lys Asn Phe  Asn Asp Tyr 
    1385                 1390                 1395             


Ala Met  Asn Phe Phe Thr Asn  Pro Thr Lys Asn Leu  Val Ser Ile 
    1400                 1405                 1410             


Thr Lys  Asp Ser Glu Leu Pro  Thr Cys Ser Cys Leu  Asp Arg Val 
    1415                 1420                 1425             


Ile Gln  Lys Asp Lys Gly Pro  Tyr Tyr Thr His Leu  Gly Ala Gly 
    1430                 1435                 1440             


Pro Ser  Val Ala Ala Val Arg  Glu Ile Met Glu Asn  Arg Tyr Gly 
    1445                 1450                 1455             


Gln Lys  Gly Asn Ala Ile Arg  Ile Glu Ile Val Val  Tyr Thr Gly 
    1460                 1465                 1470             


Lys Glu  Gly Lys Ser Ser His  Gly Cys Pro Ile Ala  Lys Trp Val 
    1475                 1480                 1485             


Leu Arg  Arg Ser Ser Asp Glu  Glu Lys Val Leu Cys  Leu Val Arg 
    1490                 1495                 1500             


Gln Arg  Thr Gly His His Cys  Pro Thr Ala Val Met  Val Val Leu 
    1505                 1510                 1515             


Ile Met  Val Trp Asp Gly Ile  Pro Leu Pro Met Ala  Asp Arg Leu 
    1520                 1525                 1530             


Tyr Thr  Glu Leu Thr Glu Asn  Leu Lys Ser Tyr Asn  Gly His Pro 
    1535                 1540                 1545             


Thr Asp  Arg Arg Cys Thr Leu  Asn Glu Asn Arg Thr  Cys Thr Cys 
    1550                 1555                 1560             


Gln Gly  Ile Asp Pro Glu Thr  Cys Gly Ala Ser Phe  Ser Phe Gly 
    1565                 1570                 1575             


Cys Ser  Trp Ser Met Tyr Phe  Asn Gly Cys Lys Phe  Gly Arg Ser 
    1580                 1585                 1590             


Pro Ser  Pro Arg Arg Phe Arg  Ile Asp Pro Ser Ser  Pro Leu His 
    1595                 1600                 1605             


Glu Lys  Asn Leu Glu Asp Asn  Leu Gln Ser Leu Ala  Thr Arg Leu 
    1610                 1615                 1620             


Ala Pro  Ile Tyr Lys Gln Tyr  Ala Pro Val Ala Tyr  Gln Asn Gln 
    1625                 1630                 1635             


Val Glu  Tyr Glu Asn Val Ala  Arg Glu Cys Arg Leu  Gly Ser Lys 
    1640                 1645                 1650             


Glu Gly  Arg Pro Phe Ser Gly  Val Thr Ala Cys Leu  Asp Phe Cys 
    1655                 1660                 1665             


Ala His  Pro His Arg Asp Ile  His Asn Met Asn Asn  Gly Ser Thr 
    1670                 1675                 1680             


Val Val  Cys Thr Leu Thr Arg  Glu Asp Asn Arg Ser  Leu Gly Val 
    1685                 1690                 1695             


Ile Pro  Gln Asp Glu Gln Leu  His Val Leu Pro Leu  Tyr Lys Leu 
    1700                 1705                 1710             


Ser Asp  Thr Asp Glu Phe Gly  Ser Lys Glu Gly Met  Glu Ala Lys 
    1715                 1720                 1725             


Ile Lys  Ser Gly Ala Ile Glu  Val Leu Ala Pro Arg  Arg Lys Lys 
    1730                 1735                 1740             


Arg Thr  Cys Phe Thr Gln Pro  Val Pro Arg Ser Gly  Lys Lys Arg 
    1745                 1750                 1755             


Ala Ala  Met Met Thr Glu Val  Leu Ala His Lys Ile  Arg Ala Val 
    1760                 1765                 1770             


Glu Lys  Lys Pro Ile Pro Arg  Ile Lys Arg Lys Asn  Asn Ser Thr 
    1775                 1780                 1785             


Thr Thr  Asn Asn Ser Lys Pro  Ser Ser Leu Pro Thr  Leu Gly Ser 
    1790                 1795                 1800             


Asn Thr  Glu Thr Val Gln Pro  Glu Val Lys Ser Glu  Thr Glu Pro 
    1805                 1810                 1815             


His Phe  Ile Leu Lys Ser Ser  Asp Asn Thr Lys Thr  Tyr Ser Leu 
    1820                 1825                 1830             


Met Pro  Ser Ala Pro His Pro  Val Lys Glu Ala Ser  Pro Gly Phe 
    1835                 1840                 1845             


Ser Trp  Ser Pro Lys Thr Ala  Ser Ala Thr Pro Ala  Pro Leu Lys 
    1850                 1855                 1860             


Asn Asp  Ala Thr Ala Ser Cys  Gly Phe Ser Glu Arg  Ser Ser Thr 
    1865                 1870                 1875             


Pro His  Cys Thr Met Pro Ser  Gly Arg Leu Ser Gly  Ala Asn Ala 
    1880                 1885                 1890             


Ala Ala  Ala Asp Gly Pro Gly  Ile Ser Gln Leu Gly  Glu Val Ala 
    1895                 1900                 1905             


Pro Leu  Pro Thr Leu Ser Ala  Pro Val Met Glu Pro  Leu Ile Asn 
    1910                 1915                 1920             


Ser Glu  Pro Ser Thr Gly Val  Thr Glu Pro Leu Thr  Pro His Gln 
    1925                 1930                 1935             


Pro Asn  His Gln Pro Ser Phe  Leu Thr Ser Pro Gln  Asp Leu Ala 
    1940                 1945                 1950             


Ser Ser  Pro Met Glu Glu Asp  Glu Gln His Ser Glu  Ala Asp Glu 
    1955                 1960                 1965             


Pro Pro  Ser Asp Glu Pro Leu  Ser Asp Asp Pro Leu  Ser Pro Ala 
    1970                 1975                 1980             


Glu Glu  Lys Leu Pro His Ile  Asp Glu Tyr Trp Ser  Asp Ser Glu 
    1985                 1990                 1995             


His Ile  Phe Leu Asp Ala Asn  Ile Gly Gly Val Ala  Ile Ala Pro 
    2000                 2005                 2010             


Ala His  Gly Ser Val Leu Ile  Glu Cys Ala Arg Arg  Glu Leu His 
    2015                 2020                 2025             


Ala Thr  Thr Pro Val Glu His  Pro Asn Arg Asn His  Pro Thr Arg 
    2030                 2035                 2040             


Leu Ser  Leu Val Phe Tyr Gln  His Lys Asn Leu Asn  Lys Pro Gln 
    2045                 2050                 2055             


His Gly  Phe Glu Leu Asn Lys  Ile Lys Phe Glu Ala  Lys Glu Ala 
    2060                 2065                 2070             


Lys Asn  Lys Lys Met Lys Ala  Ser Glu Gln Lys Asp  Gln Ala Ala 
    2075                 2080                 2085             


Asn Glu  Gly Pro Glu Gln Ser  Ser Glu Val Asn Glu  Leu Asn Gln 
    2090                 2095                 2100             


Ile Pro  Ser His Lys Ala Leu  Thr Leu Thr His Asp  Asn Val Val 
    2105                 2110                 2115             


Thr Val  Ser Pro Tyr Ala Leu  Thr His Val Ala Gly  Pro Tyr Asn 
    2120                 2125                 2130             


His Trp  Val 
    2135     


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  "X" = any amino acid

<400>  11

Cys Xaa Xaa Cys 
1               


<210>  12
<211>  5469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  12
atggactaca aggacgacga tgacaagctc gatggaggat acccctacga cgtgcccgac       60

tacgccggag gactcgacag ccagtttcag gtgcccctgg ccgtccagcc ggacctgcca      120

ggcctttatg acttccctca gcgccaggtg atggtaggga gcttcccggg gtctgggctc      180

tccatggctg ggagtgagtc ccaactccga gggggtggag atggtcgaaa gaaacggaaa      240

cggtgtggta cttgtgagcc ctgccggcgg ctggaaaact gtggcgcttg cactagctgt      300

accaaccgcc gcacgcacca gatctgcaaa ctgcgaaaat gtgaggtgct gaagaaaaaa      360

gtagggcttc tcaaggaggt ggaaataaag gctggtgaag gagccgggcc gtggggacaa      420

ggagcggctg tcaagacagg ctcagagctc agcccagttg atggacctgt tccaggtcag      480

atggactcag ggccagtgta ccatggggac tcacggcagc taagcgcctc aggggtgccg      540

gtcaatggtg ctagagagcc cgctggaccc agtctgctgg ggactggggg tccttggcgg      600

gtagaccaaa agcccgactg ggaggctgcc ccaggcccag ctcatactgc tcgcctggaa      660

gatgcccacg atctggtggc cttttcggct gtggccgaag ctgtgtcctc ttatggggcc      720

cttagcaccc ggctctatga aaccttcaac cgtgagatga gtcgtgaggc tgggaacaac      780

agcaggggac cccggccagg gcctgagggc tgctctgctg gcagcgaaga ccttgacaca      840

ctgcagacgg ccctggccct cgcgcggcat ggtatgaaac cacccaactg caactgcgat      900

ggcccagaat gccctgacta cctcgagtgg ctggagggga agatcaagtc tgtggtcatg      960

gaaggagggg aggagcggcc caggctccca gggcctctgc ctcctggtga ggccggcctc     1020

ccagcaccaa gcaccaggcc actcctcagc tcagaggtgc cccagatctc tccccaagag     1080

ggcctgcccc tgtcccagag tgccctgagc attgccaagg aaaaaaacat cagcttgcag     1140

accgccattg ccattgaggc cctcacacag ctctcctctg ccctcccgca gccttctcat     1200

tccacccccc aggcttcttg cccccttcct gaggccttgt cacctcctgc ccctttcaga     1260

tctccccagt cttacctccg ggctccctca tggcctgtgg ttcctcctga agagcactca     1320

tcttttgctc ctgatagctc tgccttccct ccagcaactc ctagaactga gttccctgaa     1380

gcctggggca ctgacacccc tccagcaacg ccccggagct cctggcccat gcctcgccca     1440

agccccgatc ccatggctga actggagcag ttgttgggca gcgccagtga ttacatccag     1500

tcagtattca agcggcctga ggccctgcct accaagccca aggtcaaggt ggaggcaccc     1560

tcttcctccc cggccccggc cccatcccct gtacttcaga gggaggctcc cacgccatcc     1620

tcggagcccg acacccacca gaaggcccag accgccctgc agcagcacct ccaccacaag     1680

cgcagcctct tcctagaaca ggtgcacgac acctccttcc ctgctccttc agagccttct     1740

gctcctggct ggtggccccc accaagttca cctgtcccac ggcttccaga cagaccaccc     1800

aaggagaaga agaagaagct cccaacacca gctggaggtc ccgtgggaac ggagaaagct     1860

gcccctggga tcaagcccag tgtccgaaag cccattcaga tcaagaagtc caggccccgg     1920

gaagcacagc ccctcttccc acctgtccga cagattgtcc tggaagggct taggtcccca     1980

gcctcccagg aagtgcaggc tcatccaccg gcccctctgc ctgcctcaca gggctctgct     2040

gtgcccctgc ccccagaacc ttctcttgcg ctatttgcac ctagtccctc cagggacagc     2100

ctgctgcccc ctactcagga aatgaggtcc cccagcccca tgacagcctt gcagccaggc     2160

tccactggcc ctcttccccc tgccgatgac aagctggaag agctcatccg gcagtttgag     2220

gctgaatttg gagatagctt tgggcttccc ggcccccctt ctgtgcccat tcaggacccc     2280

gagaaccagc aaacatgtct cccagcccct gagagcccct ttgctacccg ttcccccaag     2340

caaatcaaga ttgagtcttc gggggctgtg actgtgctct caaccacctg cttccattca     2400

gaggagggag gacaggaggc cacacccacc aaggctgaga acccactcac acccaccctc     2460

agtggcttct tggagtcacc tcttaagtac ctggacacac ccaccaagag tctgctggac     2520

acacctgcca agagagccca ggccgagttc cccacctgcg attgcgtcga acaaatagtg     2580

gagaaagatg aaggtccata ttatactcac ttgggatctg gccccacggt cgcctctatc     2640

cgggaactca tggaggagcg gtatggagag aaggggaaag ccatccggat cgagaaggtc     2700

atctacacgg ggaaggaggg aaagagctcc cgcggttgcc ccattgcaaa gtgggtgatc     2760

cgcaggcaca cgctggagga gaagctactc tgcctggtgc ggcaccgggc aggccaccac     2820

tgccagaacg ctgtgatcgt catcctcatc ctggcctggg agggcattcc ccgtagcctc     2880

ggagacaccc tctaccagga gctcaccgac accctccgga agtatgggaa ccccaccagc     2940

cggagatgcg gcctcaacga tgaccggacc tgcgcttgcc aaggcaaaga ccccaacacc     3000

tgtggtgcct ccttctcctt tggttgttcc tggagcatgt acttcaacgg ctgcaagtat     3060

gctcggagca agacacctcg caagttccgc ctcgcagggg acaatcccaa agaggaagaa     3120

gtgctccgga agagtttcca ggacctggcc accgaagtcg ctcccctgta caagcgactg     3180

gcccctcagg cctatcagaa ccaggtgacc aacgaggaaa tagcgattga ctgccgtctg     3240

gggctgaagg aaggacggcc cttcgcgggg gtcacggcct gcatggactt ctgtgcccac     3300

gcccacaagg accagcataa cctctacaat gggtgcaccg tggtctgcac cctgaccaag     3360

gaagacaatc gctgcgtggg caagattccc gaggatgagc agctgcatgt tctccccctg     3420

tacaagatgg ccaacacgga tgagtttggt agcgaggaga accagaatgc aaaggtgggc     3480

agcggagcca tccaggtgct caccgccttc ccccgcgagg tccgacgcct gcccgagcct     3540

gccaagtcct gccgccagcg gcagctggaa gccagaaagg cagcagccga gaagaagaag     3600

attcagaagg agaagctgag cactccggag aagatcaagc aggaggccct ggagctggcg     3660

ggcattacgt cggacccagg cctgtctctg aagggtggat tgtcccagca aggcctgaag     3720

ccctccctca aggtggagcc gcagaaccac ttcagctcct tcaagtacag cggcaacgcg     3780

gtggtggaga gctactcggt gctgggcaac tgccggccct ccgaccctta cagcatgaac     3840

agcgtgtact cctaccactc ctactatgca cagcccagcc tgacctccgt caatggcttc     3900

cactccaagt acgctctccc gtcttttagc tactatggct ttccatccag caaccccgtc     3960

ttcccctctc agttcctggg tcctggtgcc tgggggcata gtggcagcag tggcagtttt     4020

gagaagaagc cagacctcca cgctctgcac aacagcctga gcccggccta cggtggtgct     4080

gagtttgccg agctgcccag ccaggctgtt cccacagacg cccaccaccc cactcctcac     4140

caccagcagc ctgcgtaccc aggccccaag gagtatctgc ttcccaaggc ccccctactc     4200

cactcagtgt ccagggaccc ctcccccttt gcccagagct ccaactgcta caacagatcc     4260

atcaagcaag agccagtaga cccgctgacc caggctgagc ctgtgcccag agacgctggc     4320

aagatgggca agacacctct gtccgaggtg tctcagaatg gaggacccag tcacctttgg     4380

ggacagtact caggaggccc aagcatgtcc cccaagagga ctaacggtgt gggtggcagc     4440

tggggtgtgt tctcgtctgg ggagagtcct gccatcgtcc ctgacaagct cagttccttt     4500

ggggccagct gcctggcccc ttcccacttc acagatggcc agtgggggct gttccccggt     4560

gaggggcagc aggcagcttc ccactctgga ggacggctgc gaggcaaacc gtggagcccc     4620

tgcaagtttg ggaacagcac ctcggccttg gctgggccca gcctgactga gaagccgtgg     4680

gcgctggggg caggggattt caactcggcc ctgaaaggta gtcctgggtt ccaagacaag     4740

ctgtggaacc ccatgaaagg agaggagggc aggattccag ccgcaggggc cagccagctg     4800

gacagggcct ggcagtcctt tggtctgccc ctgggatcca gcgagaagct gtttggggct     4860

ctgaagtcag aggagaagct gtgggacccc ttcagcctgg aggaggggcc ggctgaggag     4920

ccccccagca agggagcggt gaaggaggag aagggcggtg gtggtgcgga ggaggaagag     4980

gaggagctgt ggtcggacag tgaacacaac ttcctggacg agaacatcgg cggcgtggcc     5040

gtggccccag cccacggctc catcctcatc gagtgtgccc ggcgggagct gcacgccacc     5100

acgccgctta agaagcccaa ccgctgccac cccacccgca tctcgctggt cttctaccag     5160

cacaagaacc tcaaccagcc caaccacggg ctggccctct gggaagccaa gatgaagcag     5220

ctggcggaga gggcacgggc acggcaggag gaggctgccc ggctgggcct gggccagcag     5280

gaggccaagc tctacgggaa gaagcgcaag tgggggggca ctgtggttgc tgagccccag     5340

cagaaagaga agaagggggt cgtccccacc cggcaggcac tggctgtgcc cacagactcg     5400

gcggtcaccg tgtcctccta tgcctacacg aaggtcactg gcccctacag ccgctggatc     5460

tagtctaga                                                             5469


<210>  13
<211>  1820
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  13

Met Asp Tyr Lys Asp Asp Asp Asp Lys Leu Asp Gly Gly Tyr Pro Tyr 
1               5                   10                  15      


Asp Val Pro Asp Tyr Ala Gly Gly Leu Asp Ser Gln Phe Gln Val Pro 
            20                  25                  30          


Leu Ala Val Gln Pro Asp Leu Pro Gly Leu Tyr Asp Phe Pro Gln Arg 
        35                  40                  45              


Gln Val Met Val Gly Ser Phe Pro Gly Ser Gly Leu Ser Met Ala Gly 
    50                  55                  60                  


Ser Glu Ser Gln Leu Arg Gly Gly Gly Asp Gly Arg Lys Lys Arg Lys 
65                  70                  75                  80  


Arg Cys Gly Thr Cys Glu Pro Cys Arg Arg Leu Glu Asn Cys Gly Ala 
                85                  90                  95      


Cys Thr Ser Cys Thr Asn Arg Arg Thr His Gln Ile Cys Lys Leu Arg 
            100                 105                 110         


Lys Cys Glu Val Leu Lys Lys Lys Val Gly Leu Leu Lys Glu Val Glu 
        115                 120                 125             


Ile Lys Ala Gly Glu Gly Ala Gly Pro Trp Gly Gln Gly Ala Ala Val 
    130                 135                 140                 


Lys Thr Gly Ser Glu Leu Ser Pro Val Asp Gly Pro Val Pro Gly Gln 
145                 150                 155                 160 


Met Asp Ser Gly Pro Val Tyr His Gly Asp Ser Arg Gln Leu Ser Ala 
                165                 170                 175     


Ser Gly Val Pro Val Asn Gly Ala Arg Glu Pro Ala Gly Pro Ser Leu 
            180                 185                 190         


Leu Gly Thr Gly Gly Pro Trp Arg Val Asp Gln Lys Pro Asp Trp Glu 
        195                 200                 205             


Ala Ala Pro Gly Pro Ala His Thr Ala Arg Leu Glu Asp Ala His Asp 
    210                 215                 220                 


Leu Val Ala Phe Ser Ala Val Ala Glu Ala Val Ser Ser Tyr Gly Ala 
225                 230                 235                 240 


Leu Ser Thr Arg Leu Tyr Glu Thr Phe Asn Arg Glu Met Ser Arg Glu 
                245                 250                 255     


Ala Gly Asn Asn Ser Arg Gly Pro Arg Pro Gly Pro Glu Gly Cys Ser 
            260                 265                 270         


Ala Gly Ser Glu Asp Leu Asp Thr Leu Gln Thr Ala Leu Ala Leu Ala 
        275                 280                 285             


Arg His Gly Met Lys Pro Pro Asn Cys Asn Cys Asp Gly Pro Glu Cys 
    290                 295                 300                 


Pro Asp Tyr Leu Glu Trp Leu Glu Gly Lys Ile Lys Ser Val Val Met 
305                 310                 315                 320 


Glu Gly Gly Glu Glu Arg Pro Arg Leu Pro Gly Pro Leu Pro Pro Gly 
                325                 330                 335     


Glu Ala Gly Leu Pro Ala Pro Ser Thr Arg Pro Leu Leu Ser Ser Glu 
            340                 345                 350         


Val Pro Gln Ile Ser Pro Gln Glu Gly Leu Pro Leu Ser Gln Ser Ala 
        355                 360                 365             


Leu Ser Ile Ala Lys Glu Lys Asn Ile Ser Leu Gln Thr Ala Ile Ala 
    370                 375                 380                 


Ile Glu Ala Leu Thr Gln Leu Ser Ser Ala Leu Pro Gln Pro Ser His 
385                 390                 395                 400 


Ser Thr Pro Gln Ala Ser Cys Pro Leu Pro Glu Ala Leu Ser Pro Pro 
                405                 410                 415     


Ala Pro Phe Arg Ser Pro Gln Ser Tyr Leu Arg Ala Pro Ser Trp Pro 
            420                 425                 430         


Val Val Pro Pro Glu Glu His Ser Ser Phe Ala Pro Asp Ser Ser Ala 
        435                 440                 445             


Phe Pro Pro Ala Thr Pro Arg Thr Glu Phe Pro Glu Ala Trp Gly Thr 
    450                 455                 460                 


Asp Thr Pro Pro Ala Thr Pro Arg Ser Ser Trp Pro Met Pro Arg Pro 
465                 470                 475                 480 


Ser Pro Asp Pro Met Ala Glu Leu Glu Gln Leu Leu Gly Ser Ala Ser 
                485                 490                 495     


Asp Tyr Ile Gln Ser Val Phe Lys Arg Pro Glu Ala Leu Pro Thr Lys 
            500                 505                 510         


Pro Lys Val Lys Val Glu Ala Pro Ser Ser Ser Pro Ala Pro Ala Pro 
        515                 520                 525             


Ser Pro Val Leu Gln Arg Glu Ala Pro Thr Pro Ser Ser Glu Pro Asp 
    530                 535                 540                 


Thr His Gln Lys Ala Gln Thr Ala Leu Gln Gln His Leu His His Lys 
545                 550                 555                 560 


Arg Ser Leu Phe Leu Glu Gln Val His Asp Thr Ser Phe Pro Ala Pro 
                565                 570                 575     


Ser Glu Pro Ser Ala Pro Gly Trp Trp Pro Pro Pro Ser Ser Pro Val 
            580                 585                 590         


Pro Arg Leu Pro Asp Arg Pro Pro Lys Glu Lys Lys Lys Lys Leu Pro 
        595                 600                 605             


Thr Pro Ala Gly Gly Pro Val Gly Thr Glu Lys Ala Ala Pro Gly Ile 
    610                 615                 620                 


Lys Pro Ser Val Arg Lys Pro Ile Gln Ile Lys Lys Ser Arg Pro Arg 
625                 630                 635                 640 


Glu Ala Gln Pro Leu Phe Pro Pro Val Arg Gln Ile Val Leu Glu Gly 
                645                 650                 655     


Leu Arg Ser Pro Ala Ser Gln Glu Val Gln Ala His Pro Pro Ala Pro 
            660                 665                 670         


Leu Pro Ala Ser Gln Gly Ser Ala Val Pro Leu Pro Pro Glu Pro Ser 
        675                 680                 685             


Leu Ala Leu Phe Ala Pro Ser Pro Ser Arg Asp Ser Leu Leu Pro Pro 
    690                 695                 700                 


Thr Gln Glu Met Arg Ser Pro Ser Pro Met Thr Ala Leu Gln Pro Gly 
705                 710                 715                 720 


Ser Thr Gly Pro Leu Pro Pro Ala Asp Asp Lys Leu Glu Glu Leu Ile 
                725                 730                 735     


Arg Gln Phe Glu Ala Glu Phe Gly Asp Ser Phe Gly Leu Pro Gly Pro 
            740                 745                 750         


Pro Ser Val Pro Ile Gln Asp Pro Glu Asn Gln Gln Thr Cys Leu Pro 
        755                 760                 765             


Ala Pro Glu Ser Pro Phe Ala Thr Arg Ser Pro Lys Gln Ile Lys Ile 
    770                 775                 780                 


Glu Ser Ser Gly Ala Val Thr Val Leu Ser Thr Thr Cys Phe His Ser 
785                 790                 795                 800 


Glu Glu Gly Gly Gln Glu Ala Thr Pro Thr Lys Ala Glu Asn Pro Leu 
                805                 810                 815     


Thr Pro Thr Leu Ser Gly Phe Leu Glu Ser Pro Leu Lys Tyr Leu Asp 
            820                 825                 830         


Thr Pro Thr Lys Ser Leu Leu Asp Thr Pro Ala Lys Arg Ala Gln Ala 
        835                 840                 845             


Glu Phe Pro Thr Cys Asp Cys Val Glu Gln Ile Val Glu Lys Asp Glu 
    850                 855                 860                 


Gly Pro Tyr Tyr Thr His Leu Gly Ser Gly Pro Thr Val Ala Ser Ile 
865                 870                 875                 880 


Arg Glu Leu Met Glu Glu Arg Tyr Gly Glu Lys Gly Lys Ala Ile Arg 
                885                 890                 895     


Ile Glu Lys Val Ile Tyr Thr Gly Lys Glu Gly Lys Ser Ser Arg Gly 
            900                 905                 910         


Cys Pro Ile Ala Lys Trp Val Ile Arg Arg His Thr Leu Glu Glu Lys 
        915                 920                 925             


Leu Leu Cys Leu Val Arg His Arg Ala Gly His His Cys Gln Asn Ala 
    930                 935                 940                 


Val Ile Val Ile Leu Ile Leu Ala Trp Glu Gly Ile Pro Arg Ser Leu 
945                 950                 955                 960 


Gly Asp Thr Leu Tyr Gln Glu Leu Thr Asp Thr Leu Arg Lys Tyr Gly 
                965                 970                 975     


Asn Pro Thr Ser Arg Arg Cys Gly Leu Asn Asp Asp Arg Thr Cys Ala 
            980                 985                 990         


Cys Gln Gly Lys Asp Pro Asn Thr  Cys Gly Ala Ser Phe  Ser Phe Gly 
        995                 1000                 1005             


Cys Ser  Trp Ser Met Tyr Phe  Asn Gly Cys Lys Tyr  Ala Arg Ser 
    1010                 1015                 1020             


Lys Thr  Pro Arg Lys Phe Arg  Leu Ala Gly Asp Asn  Pro Lys Glu 
    1025                 1030                 1035             


Glu Glu  Val Leu Arg Lys Ser  Phe Gln Asp Leu Ala  Thr Glu Val 
    1040                 1045                 1050             


Ala Pro  Leu Tyr Lys Arg Leu  Ala Pro Gln Ala Tyr  Gln Asn Gln 
    1055                 1060                 1065             


Val Thr  Asn Glu Glu Ile Ala  Ile Asp Cys Arg Leu  Gly Leu Lys 
    1070                 1075                 1080             


Glu Gly  Arg Pro Phe Ala Gly  Val Thr Ala Cys Met  Asp Phe Cys 
    1085                 1090                 1095             


Ala His  Ala His Lys Asp Gln  His Asn Leu Tyr Asn  Gly Cys Thr 
    1100                 1105                 1110             


Val Val  Cys Thr Leu Thr Lys  Glu Asp Asn Arg Cys  Val Gly Lys 
    1115                 1120                 1125             


Ile Pro  Glu Asp Glu Gln Leu  His Val Leu Pro Leu  Tyr Lys Met 
    1130                 1135                 1140             


Ala Asn  Thr Asp Glu Phe Gly  Ser Glu Glu Asn Gln  Asn Ala Lys 
    1145                 1150                 1155             


Val Gly  Ser Gly Ala Ile Gln  Val Leu Thr Ala Phe  Pro Arg Glu 
    1160                 1165                 1170             


Val Arg  Arg Leu Pro Glu Pro  Ala Lys Ser Cys Arg  Gln Arg Gln 
    1175                 1180                 1185             


Leu Glu  Ala Arg Lys Ala Ala  Ala Glu Lys Lys Lys  Ile Gln Lys 
    1190                 1195                 1200             


Glu Lys  Leu Ser Thr Pro Glu  Lys Ile Lys Gln Glu  Ala Leu Glu 
    1205                 1210                 1215             


Leu Ala  Gly Ile Thr Ser Asp  Pro Gly Leu Ser Leu  Lys Gly Gly 
    1220                 1225                 1230             


Leu Ser  Gln Gln Gly Leu Lys  Pro Ser Leu Lys Val  Glu Pro Gln 
    1235                 1240                 1245             


Asn His  Phe Ser Ser Phe Lys  Tyr Ser Gly Asn Ala  Val Val Glu 
    1250                 1255                 1260             


Ser Tyr  Ser Val Leu Gly Asn  Cys Arg Pro Ser Asp  Pro Tyr Ser 
    1265                 1270                 1275             


Met Asn  Ser Val Tyr Ser Tyr  His Ser Tyr Tyr Ala  Gln Pro Ser 
    1280                 1285                 1290             


Leu Thr  Ser Val Asn Gly Phe  His Ser Lys Tyr Ala  Leu Pro Ser 
    1295                 1300                 1305             


Phe Ser  Tyr Tyr Gly Phe Pro  Ser Ser Asn Pro Val  Phe Pro Ser 
    1310                 1315                 1320             


Gln Phe  Leu Gly Pro Gly Ala  Trp Gly His Ser Gly  Ser Ser Gly 
    1325                 1330                 1335             


Ser Phe  Glu Lys Lys Pro Asp  Leu His Ala Leu His  Asn Ser Leu 
    1340                 1345                 1350             


Ser Pro  Ala Tyr Gly Gly Ala  Glu Phe Ala Glu Leu  Pro Ser Gln 
    1355                 1360                 1365             


Ala Val  Pro Thr Asp Ala His  His Pro Thr Pro His  His Gln Gln 
    1370                 1375                 1380             


Pro Ala  Tyr Pro Gly Pro Lys  Glu Tyr Leu Leu Pro  Lys Ala Pro 
    1385                 1390                 1395             


Leu Leu  His Ser Val Ser Arg  Asp Pro Ser Pro Phe  Ala Gln Ser 
    1400                 1405                 1410             


Ser Asn  Cys Tyr Asn Arg Ser  Ile Lys Gln Glu Pro  Val Asp Pro 
    1415                 1420                 1425             


Leu Thr  Gln Ala Glu Pro Val  Pro Arg Asp Ala Gly  Lys Met Gly 
    1430                 1435                 1440             


Lys Thr  Pro Leu Ser Glu Val  Ser Gln Asn Gly Gly  Pro Ser His 
    1445                 1450                 1455             


Leu Trp  Gly Gln Tyr Ser Gly  Gly Pro Ser Met Ser  Pro Lys Arg 
    1460                 1465                 1470             


Thr Asn  Gly Val Gly Gly Ser  Trp Gly Val Phe Ser  Ser Gly Glu 
    1475                 1480                 1485             


Ser Pro  Ala Ile Val Pro Asp  Lys Leu Ser Ser Phe  Gly Ala Ser 
    1490                 1495                 1500             


Cys Leu  Ala Pro Ser His Phe  Thr Asp Gly Gln Trp  Gly Leu Phe 
    1505                 1510                 1515             


Pro Gly  Glu Gly Gln Gln Ala  Ala Ser His Ser Gly  Gly Arg Leu 
    1520                 1525                 1530             


Arg Gly  Lys Pro Trp Ser Pro  Cys Lys Phe Gly Asn  Ser Thr Ser 
    1535                 1540                 1545             


Ala Leu  Ala Gly Pro Ser Leu  Thr Glu Lys Pro Trp  Ala Leu Gly 
    1550                 1555                 1560             


Ala Gly  Asp Phe Asn Ser Ala  Leu Lys Gly Ser Pro  Gly Phe Gln 
    1565                 1570                 1575             


Asp Lys  Leu Trp Asn Pro Met  Lys Gly Glu Glu Gly  Arg Ile Pro 
    1580                 1585                 1590             


Ala Ala  Gly Ala Ser Gln Leu  Asp Arg Ala Trp Gln  Ser Phe Gly 
    1595                 1600                 1605             


Leu Pro  Leu Gly Ser Ser Glu  Lys Leu Phe Gly Ala  Leu Lys Ser 
    1610                 1615                 1620             


Glu Glu  Lys Leu Trp Asp Pro  Phe Ser Leu Glu Glu  Gly Pro Ala 
    1625                 1630                 1635             


Glu Glu  Pro Pro Ser Lys Gly  Ala Val Lys Glu Glu  Lys Gly Gly 
    1640                 1645                 1650             


Gly Gly  Ala Glu Glu Glu Glu  Glu Glu Leu Trp Ser  Asp Ser Glu 
    1655                 1660                 1665             


His Asn  Phe Leu Asp Glu Asn  Ile Gly Gly Val Ala  Val Ala Pro 
    1670                 1675                 1680             


Ala His  Gly Ser Ile Leu Ile  Glu Cys Ala Arg Arg  Glu Leu His 
    1685                 1690                 1695             


Ala Thr  Thr Pro Leu Lys Lys  Pro Asn Arg Cys His  Pro Thr Arg 
    1700                 1705                 1710             


Ile Ser  Leu Val Phe Tyr Gln  His Lys Asn Leu Asn  Gln Pro Asn 
    1715                 1720                 1725             


His Gly  Leu Ala Leu Trp Glu  Ala Lys Met Lys Gln  Leu Ala Glu 
    1730                 1735                 1740             


Arg Ala  Arg Ala Arg Gln Glu  Glu Ala Ala Arg Leu  Gly Leu Gly 
    1745                 1750                 1755             


Gln Gln  Glu Ala Lys Leu Tyr  Gly Lys Lys Arg Lys  Trp Gly Gly 
    1760                 1765                 1770             


Thr Val  Val Ala Glu Pro Gln  Gln Lys Glu Lys Lys  Gly Val Val 
    1775                 1780                 1785             


Pro Thr  Arg Gln Ala Leu Ala  Val Pro Thr Asp Ser  Ala Val Thr 
    1790                 1795                 1800             


Val Ser  Ser Tyr Ala Tyr Thr  Lys Val Thr Gly Pro  Tyr Ser Arg 
    1805                 1810                 1815             


Trp Ile  
    1820 


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  14
cccaaagagg aagaagtg                                                     18


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  15
gcagtcaatc gctatttc                                                     18


