                         SEQUENCE LISTING

<110>  Massachusetts Institute of Technology
 
<120>  PHOSPHORYLATION-BASED MIRNA SENSOR

<130>  M0656.70450WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/713,160
<151>  2018-08-01

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  450
<212>  PRT
<213>  Escherichia coli

<400>  1

Met Arg Arg Leu Arg Phe Ser Pro Arg Ser Ser Phe Ala Arg Thr Leu 
1               5                   10                  15      


Leu Leu Ile Val Thr Leu Leu Phe Ala Ser Leu Val Thr Thr Tyr Leu 
            20                  25                  30          


Val Val Leu Asn Phe Ala Ile Leu Pro Ser Leu Gln Gln Phe Asn Lys 
        35                  40                  45              


Val Leu Ala Tyr Glu Val Arg Met Leu Met Thr Asp Lys Leu Gln Leu 
    50                  55                  60                  


Glu Asp Gly Thr Gln Leu Val Val Pro Pro Ala Phe Arg Arg Glu Ile 
65                  70                  75                  80  


Tyr Arg Glu Leu Gly Ile Ser Leu Tyr Ser Asn Glu Ala Ala Glu Glu 
                85                  90                  95      


Ala Gly Leu Arg Trp Ala Gln His Tyr Glu Phe Leu Ser His Gln Met 
            100                 105                 110         


Ala Gln Gln Leu Gly Gly Pro Thr Glu Val Arg Val Glu Val Asn Lys 
        115                 120                 125             


Ser Ser Pro Val Val Trp Leu Lys Thr Trp Leu Ser Pro Asn Ile Trp 
    130                 135                 140                 


Val Arg Val Pro Leu Thr Glu Ile His Gln Gly Asp Phe Ser Pro Leu 
145                 150                 155                 160 


Phe Arg Tyr Thr Leu Ala Ile Met Leu Leu Ala Ile Gly Gly Ala Trp 
                165                 170                 175     


Leu Phe Ile Arg Ile Gln Asn Arg Pro Leu Val Asp Leu Glu His Ala 
            180                 185                 190         


Ala Leu Gln Val Gly Lys Gly Ile Ile Pro Pro Pro Leu Arg Glu Tyr 
        195                 200                 205             


Gly Ala Ser Glu Val Arg Ser Val Thr Arg Ala Phe Asn His Met Ala 
    210                 215                 220                 


Ala Gly Val Lys Gln Leu Ala Asp Asp Arg Thr Leu Leu Met Ala Gly 
225                 230                 235                 240 


Val Ser His Asp Leu Arg Thr Pro Leu Thr Arg Ile Arg Leu Ala Thr 
                245                 250                 255     


Glu Met Met Ser Glu Gln Asp Gly Tyr Leu Ala Glu Ser Ile Asn Lys 
            260                 265                 270         


Asp Ile Glu Glu Cys Asn Ala Ile Ile Glu Gln Phe Ile Asp Tyr Leu 
        275                 280                 285             


Arg Thr Gly Gln Glu Met Pro Met Glu Met Ala Asp Leu Asn Ala Val 
    290                 295                 300                 


Leu Gly Glu Val Ile Ala Ala Glu Ser Gly Tyr Glu Arg Glu Ile Glu 
305                 310                 315                 320 


Thr Ala Leu Tyr Pro Gly Ser Ile Glu Val Lys Met His Pro Leu Ser 
                325                 330                 335     


Ile Lys Arg Ala Val Ala Asn Met Val Val Asn Ala Ala Arg Tyr Gly 
            340                 345                 350         


Asn Gly Trp Ile Lys Val Ser Ser Gly Thr Glu Pro Asn Arg Ala Trp 
        355                 360                 365             


Phe Gln Val Glu Asp Asp Gly Pro Gly Ile Ala Pro Glu Gln Arg Lys 
    370                 375                 380                 


His Leu Phe Gln Pro Phe Val Arg Gly Asp Ser Ala Arg Thr Ile Ser 
385                 390                 395                 400 


Gly Thr Gly Leu Gly Leu Ala Ile Val Gln Arg Ile Val Asp Asn His 
                405                 410                 415     


Asn Gly Met Leu Glu Leu Gly Thr Ser Glu Arg Gly Gly Leu Ser Ile 
            420                 425                 430         


Arg Ala Trp Leu Pro Val Pro Val Thr Arg Ala Gln Gly Thr Thr Lys 
        435                 440                 445             


Glu Gly 
    450 


<210>  2
<211>  450
<212>  PRT
<213>  Escherichia coli

<400>  2

Met Arg Arg Leu Arg Phe Ser Pro Arg Ser Ser Phe Ala Arg Thr Leu 
1               5                   10                  15      


Leu Leu Ile Val Thr Leu Leu Phe Ala Ser Leu Val Thr Thr Tyr Leu 
            20                  25                  30          


Val Val Leu Asn Phe Ala Ile Leu Pro Ser Leu Gln Gln Phe Asn Lys 
        35                  40                  45              


Val Leu Ala Tyr Glu Val Arg Met Leu Met Thr Asp Lys Leu Gln Leu 
    50                  55                  60                  


Glu Asp Gly Thr Gln Leu Val Val Pro Pro Ala Phe Arg Arg Glu Ile 
65                  70                  75                  80  


Tyr Arg Glu Leu Gly Ile Ser Leu Tyr Ser Asn Glu Ala Ala Glu Glu 
                85                  90                  95      


Ala Gly Leu Arg Trp Ala Gln His Tyr Glu Phe Leu Ser His Gln Met 
            100                 105                 110         


Ala Gln Gln Leu Gly Gly Pro Thr Glu Val Arg Val Glu Val Asn Lys 
        115                 120                 125             


Ser Ser Pro Val Val Trp Leu Lys Thr Trp Leu Ser Pro Asn Ile Trp 
    130                 135                 140                 


Val Arg Val Pro Leu Thr Glu Ile His Gln Gly Asp Phe Ser Pro Leu 
145                 150                 155                 160 


Phe Arg Tyr Thr Leu Ala Ile Met Leu Leu Ala Ile Gly Gly Ala Trp 
                165                 170                 175     


Leu Phe Ile Arg Ile Gln Asn Arg Pro Leu Val Asp Leu Glu His Ala 
            180                 185                 190         


Ala Leu Gln Val Gly Lys Gly Ile Ile Pro Pro Pro Leu Arg Glu Tyr 
        195                 200                 205             


Gly Ala Ser Glu Val Arg Ser Val Thr Arg Ala Phe Asn His Met Ala 
    210                 215                 220                 


Ala Gly Val Lys Gln Leu Ala Asp Asp Arg Thr Leu Leu Met Ala Gly 
225                 230                 235                 240 


Val Ser His Ala Leu Arg Thr Pro Leu Thr Arg Ile Arg Leu Ala Thr 
                245                 250                 255     


Glu Met Met Ser Glu Gln Asp Gly Tyr Leu Ala Glu Ser Ile Asn Lys 
            260                 265                 270         


Asp Ile Glu Glu Cys Asn Ala Ile Ile Glu Gln Phe Ile Asp Tyr Leu 
        275                 280                 285             


Arg Thr Gly Gln Glu Met Pro Met Glu Met Ala Asp Leu Asn Ala Val 
    290                 295                 300                 


Leu Gly Glu Val Ile Ala Ala Glu Ser Gly Tyr Glu Arg Glu Ile Glu 
305                 310                 315                 320 


Thr Ala Leu Tyr Pro Gly Ser Ile Glu Val Lys Met His Pro Leu Ser 
                325                 330                 335     


Ile Lys Arg Ala Val Ala Asn Met Val Val Asn Ala Ala Arg Tyr Gly 
            340                 345                 350         


Asn Gly Trp Ile Lys Val Ser Ser Gly Thr Glu Pro Asn Arg Ala Trp 
        355                 360                 365             


Phe Gln Val Glu Asp Asp Gly Pro Gly Ile Ala Pro Glu Gln Arg Lys 
    370                 375                 380                 


His Leu Phe Gln Pro Phe Val Arg Gly Asp Ser Ala Arg Thr Ile Ser 
385                 390                 395                 400 


Gly Thr Gly Leu Gly Leu Ala Ile Val Gln Arg Ile Val Asp Asn His 
                405                 410                 415     


Asn Gly Met Leu Glu Leu Gly Thr Ser Glu Arg Gly Gly Leu Ser Ile 
            420                 425                 430         


Arg Ala Trp Leu Pro Val Pro Val Thr Arg Ala Gln Gly Thr Thr Lys 
        435                 440                 445             


Glu Gly 
    450 


<210>  3
<211>  450
<212>  PRT
<213>  Escherichia coli

<400>  3

Met Arg Arg Leu Arg Phe Ser Pro Arg Ser Ser Phe Ala Arg Thr Leu 
1               5                   10                  15      


Leu Leu Ile Val Thr Leu Leu Phe Ala Ser Leu Val Thr Thr Tyr Leu 
            20                  25                  30          


Val Val Leu Asn Phe Ala Ile Leu Pro Ser Leu Gln Gln Phe Asn Lys 
        35                  40                  45              


Val Leu Ala Tyr Glu Val Arg Met Leu Met Thr Asp Lys Leu Gln Leu 
    50                  55                  60                  


Glu Asp Gly Thr Gln Leu Val Val Pro Pro Ala Phe Arg Arg Glu Ile 
65                  70                  75                  80  


Tyr Arg Glu Leu Gly Ile Ser Leu Tyr Ser Asn Glu Ala Ala Glu Glu 
                85                  90                  95      


Ala Gly Leu Arg Trp Ala Gln His Tyr Glu Phe Leu Ser His Gln Met 
            100                 105                 110         


Ala Gln Gln Leu Gly Gly Pro Thr Glu Val Arg Val Glu Val Asn Lys 
        115                 120                 125             


Ser Ser Pro Val Val Trp Leu Lys Thr Trp Leu Ser Pro Asn Ile Trp 
    130                 135                 140                 


Val Arg Val Pro Leu Thr Glu Ile His Gln Gly Asp Phe Ser Pro Leu 
145                 150                 155                 160 


Phe Arg Tyr Thr Leu Ala Ile Met Leu Leu Ala Ile Gly Gly Ala Trp 
                165                 170                 175     


Leu Phe Ile Arg Ile Gln Asn Arg Pro Leu Val Asp Leu Glu His Ala 
            180                 185                 190         


Ala Leu Gln Val Gly Lys Gly Ile Ile Pro Pro Pro Leu Arg Glu Tyr 
        195                 200                 205             


Gly Ala Ser Glu Val Arg Ser Val Thr Arg Ala Phe Asn His Met Ala 
    210                 215                 220                 


Ala Gly Val Lys Gln Leu Ala Asp Asp Arg Thr Leu Leu Met Ala Gly 
225                 230                 235                 240 


Val Ser His Asp Leu Arg Ala Pro Leu Thr Arg Ile Arg Leu Ala Thr 
                245                 250                 255     


Glu Met Met Ser Glu Gln Asp Gly Tyr Leu Ala Glu Ser Ile Asn Lys 
            260                 265                 270         


Asp Ile Glu Glu Cys Asn Ala Ile Ile Glu Gln Phe Ile Asp Tyr Leu 
        275                 280                 285             


Arg Thr Gly Gln Glu Met Pro Met Glu Met Ala Asp Leu Asn Ala Val 
    290                 295                 300                 


Leu Gly Glu Val Ile Ala Ala Glu Ser Gly Tyr Glu Arg Glu Ile Glu 
305                 310                 315                 320 


Thr Ala Leu Tyr Pro Gly Ser Ile Glu Val Lys Met His Pro Leu Ser 
                325                 330                 335     


Ile Lys Arg Ala Val Ala Asn Met Val Val Asn Ala Ala Arg Tyr Gly 
            340                 345                 350         


Asn Gly Trp Ile Lys Val Ser Ser Gly Thr Glu Pro Asn Arg Ala Trp 
        355                 360                 365             


Phe Gln Val Glu Asp Asp Gly Pro Gly Ile Ala Pro Glu Gln Arg Lys 
    370                 375                 380                 


His Leu Phe Gln Pro Phe Val Arg Gly Asp Ser Ala Arg Thr Ile Ser 
385                 390                 395                 400 


Gly Thr Gly Leu Gly Leu Ala Ile Val Gln Arg Ile Val Asp Asn His 
                405                 410                 415     


Asn Gly Met Leu Glu Leu Gly Thr Ser Glu Arg Gly Gly Leu Ser Ile 
            420                 425                 430         


Arg Ala Trp Leu Pro Val Pro Val Thr Arg Ala Gln Gly Thr Thr Lys 
        435                 440                 445             


Glu Gly 
    450 


<210>  4
<211>  67
<212>  PRT
<213>  Escherichia coli

<400>  4

Met Ala Ala Gly Val Lys Gln Leu Ala Asp Asp Arg Thr Leu Leu Met 
1               5                   10                  15      


Ala Gly Val Ser His Asp Leu Arg Ala Pro Leu Thr Arg Ile Arg Leu 
            20                  25                  30          


Ala Thr Glu Met Met Ser Glu Gln Asp Gly Tyr Leu Ala Glu Ser Ile 
        35                  40                  45              


Asn Lys Asp Ile Glu Glu Cys Asn Ala Ile Ile Glu Gln Phe Ile Asp 
    50                  55                  60                  


Tyr Leu Arg 
65          


<210>  5
<211>  303
<212>  PRT
<213>  Escherichia coli

<400>  5

Met Ala Ala Gly Val Lys Gln Leu Ala Asp Asp Arg Thr Leu Leu Met 
1               5                   10                  15      


Ala Gly Val Ser His Asp Leu Arg Thr Pro Leu Thr Arg Ile Arg Leu 
            20                  25                  30          


Ala Thr Glu Met Met Ser Glu Gln Asp Gly Tyr Leu Ala Glu Ser Ile 
        35                  40                  45              


Asn Lys Asp Ile Glu Glu Cys Asn Ala Ile Ile Glu Gln Phe Ile Asp 
    50                  55                  60                  


Tyr Leu Arg Gly Gly Ser Ile Gly Gly Ser Ile Met Ala Ala Gly Val 
65                  70                  75                  80  


Lys Gln Leu Ala Asp Asp Arg Thr Leu Leu Met Ala Gly Val Ser His 
                85                  90                  95      


Asp Leu Arg Thr Pro Leu Thr Arg Ile Arg Leu Ala Thr Glu Met Met 
            100                 105                 110         


Ser Glu Gln Asp Gly Tyr Leu Ala Glu Ser Ile Asn Lys Asp Ile Glu 
        115                 120                 125             


Glu Cys Asn Ala Ile Ile Glu Gln Phe Ile Asp Tyr Leu Arg Thr Gly 
    130                 135                 140                 


Gln Glu Met Pro Met Glu Met Ala Asp Leu Asn Ala Val Leu Gly Glu 
145                 150                 155                 160 


Val Ile Ala Ala Glu Ser Gly Tyr Glu Arg Glu Ile Glu Thr Ala Leu 
                165                 170                 175     


Tyr Pro Gly Ser Ile Glu Val Lys Met His Pro Leu Ser Ile Lys Arg 
            180                 185                 190         


Ala Val Ala Asn Met Val Val Asn Ala Ala Arg Tyr Gly Asn Gly Trp 
        195                 200                 205             


Ile Lys Val Ser Ser Gly Thr Glu Pro Asn Arg Ala Trp Phe Gln Val 
    210                 215                 220                 


Glu Asp Asp Gly Pro Gly Ile Ala Pro Glu Gln Arg Lys His Leu Phe 
225                 230                 235                 240 


Gln Pro Phe Val Arg Gly Asp Ser Ala Arg Thr Ile Ser Gly Thr Gly 
                245                 250                 255     


Leu Gly Leu Ala Ile Val Gln Arg Ile Val Asp Asn His Asn Gly Met 
            260                 265                 270         


Leu Glu Leu Gly Thr Ser Glu Arg Gly Gly Leu Ser Ile Arg Ala Trp 
        275                 280                 285             


Leu Pro Val Pro Val Thr Arg Ala Gln Gly Thr Thr Lys Glu Gly 
    290                 295                 300             


<210>  6
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly 
1               5                   10                  15      


Glu Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu 
            20                  25                  30          


Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His 
        35                  40                  45              


Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu 
    50                  55                  60                  


Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly 
65                  70                  75              


<210>  7
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Glu Ala Ser Gly Ser Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu 
1               5                   10                  15      


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
            20                  25                  30          


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
        35                  40                  45              


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ile Asn Ser Arg 
    50                  55                  60          


<210>  8
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys 
1               5                   10                  15      


Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro 
            20                  25                  30          


Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val 
        35                  40                  45              


Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr 
    50                  55                  60                  


Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr 
65                  70                  75                  80  


Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro 
                85                  90                  95      


Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro 
            100                 105                 110         


Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu 
        115                 120                 125             


Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr 
    130                 135                 140                 


Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe 
145                 150                 155                 160 


Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala 
                165                 170                 175     


Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu 
            180                 185                 190         


Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu 
        195                 200                 205             


Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg 
    210                 215                 220                 


Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn 
225                 230                 235                 240 


Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp 
                245                 250                 255     


Phe Ser Ala Leu Leu 
            260     


<210>  9
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
1               5                   10                  15      


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
            20                  25                  30          


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
        35                  40                  45              


Leu Asp Met Leu Ile Asn Ser Arg Ser Ser Gly Ser Pro Lys Lys Lys 
    50                  55                  60                  


Arg Lys Val Gly Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg 
65                  70                  75                  80  


Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met 
                85                  90                  95      


Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg 
            100                 105                 110         


Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala 
        115                 120                 125             


Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp 
    130                 135                 140                 


Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser 
145                 150                 155                 160 


Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro 
                165                 170                 175     


Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro 
            180                 185                 190         


Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala 
        195                 200                 205             


Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu 
    210                 215                 220                 


Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser 
225                 230                 235                 240 


Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu 
                245                 250                 255     


Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr 
            260                 265                 270         


Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr 
        275                 280                 285             


Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro 
    290                 295                 300                 


Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile 
305                 310                 315                 320 


Ala Asp Met Asp Phe Ser Ala Leu Leu Gly Ser Gly Ser Gly Ser Arg 
                325                 330                 335     


Asp Ser Arg Glu Gly Met Phe Leu Pro Lys Pro Glu Ala Gly Ser Ala 
            340                 345                 350         


Ile Ser Asp Val Phe Glu Gly Arg Glu Val Cys Gln Pro Lys Arg Ile 
        355                 360                 365             


Arg Pro Phe His Pro Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu Pro 
    370                 375                 380                 


Ala Ser Leu Ala Pro Thr Pro Thr Gly Pro Val His Glu Pro Val Gly 
385                 390                 395                 400 


Ser Leu Thr Pro Ala Pro Val Pro Gln Pro Leu Asp Pro Ala Pro Ala 
                405                 410                 415     


Val Thr Pro Glu Ala Ser His Leu Leu Glu Asp Pro Asp Glu Glu Thr 
            420                 425                 430         


Ser Gln Ala Val Lys Ala Leu Arg Glu Met Ala Asp Thr Val Ile Pro 
        435                 440                 445             


Gln Lys Glu Glu Ala Ala Ile Cys Gly Gln Met Asp Leu Ser His Pro 
    450                 455                 460                 


Pro Pro Arg Gly His Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser Met 
465                 470                 475                 480 


Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn Glu 
                485                 490                 495     


Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys Leu Leu His Ala Met His 
            500                 505                 510         


Ile Ser Thr Gly Leu Ser Ile Phe Asp Thr Ser Leu Phe 
        515                 520                 525 


<210>  10
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Met Gln Glu Asn Tyr Lys Ile Leu Val Val Asp Asp Asp Met Arg Leu 
1               5                   10                  15      


Arg Ala Leu Leu Glu Arg Tyr Leu Thr Glu Gln Gly Phe Gln Val Arg 
            20                  25                  30          


Ser Val Ala Asn Ala Glu Gln Met Asp Arg Leu Leu Thr Arg Glu Ser 
        35                  40                  45              


Phe His Leu Met Val Leu Asp Leu Met Leu Pro Gly Glu Asp Gly Leu 
    50                  55                  60                  


Ser Ile Cys Arg Arg Leu Arg Ser Gln Ser Asn Pro Met Pro Ile Ile 
65                  70                  75                  80  


Met Val Thr Ala Lys Gly Glu Glu Val Asp Arg Ile Val Gly Leu Glu 
                85                  90                  95      


Ile Gly Ala Asp Asp Tyr Ile Pro Lys Pro Phe Asn Pro Arg Glu Leu 
            100                 105                 110         


Leu Ala Arg Ile Arg Ala Val Leu Arg Arg Gln Ala Asn Glu Leu Pro 
        115                 120                 125             


Gly Ala Pro Ser Gln Glu Glu Ala Val Ile Ala Phe Gly Lys Phe Lys 
    130                 135                 140                 


Leu Asn Leu Gly Thr Arg Glu Met Phe Arg Glu Asp Glu Pro Met Pro 
145                 150                 155                 160 


Leu Thr Ser Gly Glu Phe Ala Val Leu Lys Ala Leu Val Ser His Pro 
                165                 170                 175     


Arg Glu Pro Leu Ser Arg Asp Lys Leu Met Asn Leu Ala Arg Gly Arg 
            180                 185                 190         


Glu Tyr Ser Ala Met Glu Arg Ser Ile Asp Val Gln Ile Ser Arg Leu 
        195                 200                 205             


Arg Arg Met Val Glu Glu Asp Pro Ala His Pro Arg Tyr Ile Gln Thr 
    210                 215                 220                 


Val Trp Gly Leu Gly Tyr Val Phe Val Pro Asp Gly Ser Lys Ala 
225                 230                 235                 


<210>  11
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Met Ser Asn Gln Glu Pro Ala Thr Ile Leu Leu Ile Asp Asp His Pro 
1               5                   10                  15      


Met Leu Arg Thr Gly Val Lys Gln Leu Ile Ser Met Ala Pro Asp Ile 
            20                  25                  30          


Thr Val Val Gly Glu Ala Ser Asn Gly Glu Gln Gly Ile Glu Leu Ala 
        35                  40                  45              


Glu Ser Leu Asp Pro Asp Leu Ile Leu Leu Asp Leu Asn Met Pro Gly 
    50                  55                  60                  


Met Asn Gly Leu Glu Thr Leu Asp Lys Leu Arg Glu Lys Ser Leu Ser 
65                  70                  75                  80  


Gly Arg Ile Val Val Phe Ser Val Ser Asn His Glu Glu Asp Val Val 
                85                  90                  95      


Thr Ala Leu Lys Arg Gly Ala Asp Gly Tyr Leu Leu Lys Asp Met Glu 
            100                 105                 110         


Pro Glu Asp Leu Leu Lys Ala Leu His Gln Ala Ala Ala Gly Glu Met 
        115                 120                 125             


Val Leu Ser Glu Ala Leu Thr Pro Val Leu Ala Ala Ser Leu Arg Ala 
    130                 135                 140                 


Asn Arg Ala Thr Thr Glu Arg Asp Val Asn Gln Leu Thr Pro Arg Glu 
145                 150                 155                 160 


Arg Asp Ile Leu Lys Leu Ile Ala Gln Gly Leu Pro Asn Lys Met Ile 
                165                 170                 175     


Ala Arg Arg Leu Asp Ile Thr Glu Ser Thr Val Lys Val His Val Lys 
            180                 185                 190         


His Met Leu Lys Lys Met Lys Leu Lys Ser Arg Val Glu Ala Ala Val 
        195                 200                 205             


Trp Val His Gln Glu Arg Ile Phe 
    210                 215     


<210>  12
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Met Gln Arg Gly Ile Val Trp Val Val Asp Asp Asp Ser Ser Ile Arg 
1               5                   10                  15      


Trp Val Leu Glu Arg Ala Leu Ala Gly Ala Gly Leu Thr Cys Thr Thr 
            20                  25                  30          


Phe Glu Asn Gly Ala Glu Val Leu Glu Ala Leu Ala Ser Lys Thr Pro 
        35                  40                  45              


Asp Val Leu Leu Ser Asp Ile Arg Met Pro Gly Met Asp Gly Leu Ala 
    50                  55                  60                  


Leu Leu Lys Gln Ile Lys Gln Arg His Pro Met Leu Pro Val Ile Ile 
65                  70                  75                  80  


Met Thr Ala His Ser Asp Leu Asp Ala Ala Val Ser Ala Tyr Gln Gln 
                85                  90                  95      


Gly Ala Phe Asp Tyr Leu Pro Lys Pro Phe Asp Ile Asp Glu Ala Val 
            100                 105                 110         


Ala Leu Val Glu Arg Ala Ile Ser His Tyr Gln Glu Gln Gln Gln Pro 
        115                 120                 125             


Arg Asn Val Gln Leu Asn Gly Pro Thr Thr Asp Ile Ile Gly Glu Ala 
    130                 135                 140                 


Pro Ala Met Gln Asp Val Phe Arg Ile Ile Gly Arg Leu Ser Arg Ser 
145                 150                 155                 160 


Ser Ile Ser Val Leu Ile Asn Gly Glu Ser Gly Thr Gly Lys Glu Leu 
                165                 170                 175     


Val Ala His Ala Leu His Arg His Ser Pro Arg Ala Lys Ala Pro Phe 
            180                 185                 190         


Ile Ala Leu Asn Met Ala Ala Ile Pro Lys Asp Leu Ile Glu Ser Glu 
        195                 200                 205             


Leu Phe Gly His Glu Lys Gly Ala Phe Thr Gly Ala Asn Thr Ile Arg 
    210                 215                 220                 


Gln Gly Arg Phe Glu Gln Ala Asp Gly Gly Thr Leu Phe Leu Asp Glu 
225                 230                 235                 240 


Ile Gly Asp Met Pro Leu Asp Val Gln Thr Arg Leu Leu Arg Val Leu 
                245                 250                 255     


Ala Asp Gly Gln Phe Tyr Arg Val Gly Gly Tyr Ala Pro Val Lys Val 
            260                 265                 270         


Asp Val Arg Ile Ile Ala Ala Thr His Gln Asn Leu Glu Gln Arg Val 
        275                 280                 285             


Gln Glu Gly Lys Phe Arg Glu Asp Leu Phe His Arg Leu Asn Val Ile 
    290                 295                 300                 


Arg Val His Leu Pro Pro Leu Arg Glu Arg Arg Glu Asp Ile Pro Arg 
305                 310                 315                 320 


Leu Ala Arg His Phe Leu Gln Val Ala Ala Arg Glu Leu Gly Val Glu 
                325                 330                 335     


Ala Lys Leu Leu His Pro Glu Thr Glu Ala Ala Leu Thr Arg Leu Ala 
            340                 345                 350         


Trp Pro Gly Asn Val Arg Gln Leu Glu Asn Thr Cys Arg Trp Leu Thr 
        355                 360                 365             


Val Met Ala Ala Gly Gln Glu Val Leu Ile Gln Asp Leu Pro Gly Glu 
    370                 375                 380                 


Leu Phe Glu Ser Thr Val Ala Glu Ser Thr Ser Gln Met Gln Pro Asp 
385                 390                 395                 400 


Ser Trp Ala Thr Leu Leu Ala Gln Trp Ala Asp Arg Ala Leu Arg Ser 
                405                 410                 415     


Gly His Gln Asn Leu Leu Ser Glu Ala Gln Pro Glu Leu Glu Arg Thr 
            420                 425                 430         


Leu Leu Thr Thr Ala Leu Arg His Thr Gln Gly His Lys Gln Glu Ala 
        435                 440                 445             


Ala Arg Leu Leu Gly Trp Gly Arg Asn Thr Leu Thr Arg Lys Leu Lys 
    450                 455                 460                 


Glu Leu Gly Met Glu 
465                 


<210>  13
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Met Ala Arg Arg Ile Leu Val Val Glu Asp Glu Ala Pro Ile Arg Glu 
1               5                   10                  15      


Met Val Cys Phe Val Leu Glu Gln Asn Gly Phe Gln Pro Val Glu Ala 
            20                  25                  30          


Glu Asp Tyr Asp Ser Ala Val Asn Gln Leu Asn Glu Pro Trp Pro Asp 
        35                  40                  45              


Leu Ile Leu Leu Asp Trp Met Leu Pro Gly Gly Ser Gly Ile Gln Phe 
    50                  55                  60                  


Ile Lys His Leu Lys Arg Glu Ser Met Thr Arg Asp Ile Pro Val Val 
65                  70                  75                  80  


Met Leu Thr Ala Arg Gly Glu Glu Glu Asp Arg Val Arg Gly Leu Glu 
                85                  90                  95      


Thr Gly Ala Asp Asp Tyr Ile Thr Lys Pro Phe Ser Pro Lys Glu Leu 
            100                 105                 110         


Val Ala Arg Ile Lys Ala Val Met Arg Arg Ile Ser Pro Met Ala Val 
        115                 120                 125             


Glu Glu Val Ile Glu Met Gln Gly Leu Ser Leu Asp Pro Thr Ser His 
    130                 135                 140                 


Arg Val Met Ala Gly Glu Glu Pro Leu Glu Met Gly Pro Thr Glu Phe 
145                 150                 155                 160 


Lys Leu Leu His Phe Phe Met Thr His Pro Glu Arg Val Tyr Ser Arg 
                165                 170                 175     


Glu Gln Leu Leu Asn His Val Trp Gly Thr Asn Val Tyr Val Glu Asp 
            180                 185                 190         


Arg Thr Val Asp Val His Ile Arg Arg Leu Arg Lys Ala Leu Glu Pro 
        195                 200                 205             


Gly Gly His Asp Arg Met Val Gln Thr Val Arg Gly Thr Gly Tyr Arg 
    210                 215                 220                 


Phe Ser Thr Arg Phe 
225                 


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
atttacattt tgaaacatct a                                                 21


<210>  15
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
taccgctatt gaggta                                                       16


<210>  16
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
tgcactaaaa tggtgca                                                      17


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  w may be a or t

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  w may be a or t

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  y may be c or t

<400>  17
ctgtcatawa wctgtcay                                                     18


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
tttgtattca gcccatatcg                                                   20


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  19
aacgatatgg gctgaataca aa                                                22


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  20
tttaattaaa gacttcaagc g                                                 21


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  21
ccgcttgaag tctttaatta aa                                                22


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  22
taattgtcaa atcagagtgc                                                   20


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  23
aagcactctg atttgacaat ta                                                22


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  24
tttatgagga atctctttgg                                                   20


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  25
aaccaaagag attcctcata aa                                                22


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  26
ttcgaagtat tccgcgtacg                                                   20


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  27
cacgtacgcg gaatacttcg aa                                                22


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  28
atttacattt tgaaacatct a                                                 21


<210>  29
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  29
taccgctatt gaggta                                                       16


<210>  30
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  30
tgcactaaaa tggtgca                                                      17


<210>  31
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  w may be a or t

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  w may be a or t

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  y may be c or t

<400>  31
ctgtcatawa wctgtcay                                                     18


