                               SEQUENCE LISTING

<110> NOVARTIS AG
 
<120> NEW MYOKINES AND USES THEREOF

<130> PAT058202A

<140> EP 18187131.0
<141> 2018-08-02

<160> 68    

<170> PatentIn version 3.5

<210> 1
<211> 131
<212> PRT
<213> Homo sapiens

<400> 1
Met Asp Val Leu Phe Val Ala Ile Phe Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser Ala 
        35                  40                  45              


Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile Ser Leu 
65                  70                  75                  80  


Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
                85                  90                  95      


Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Arg 
            100                 105                 110         


Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val Gly Met 
        115                 120                 125             


Tyr Phe Met 
    130     


<210> 2
<211> 115
<212> PRT
<213> Homo sapiens

<400> 2
Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr Tyr Gln 
1               5                   10                  15      


Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser Ala 
            20                  25                  30          


Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
        35                  40                  45              


Arg Leu Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile Ser Leu 
    50                  55                  60                  


Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
65                  70                  75                  80  


Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Arg 
                85                  90                  95      


Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val Gly Met 
            100                 105                 110         


Tyr Phe Met 
        115 


<210> 3
<211> 100
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr Tyr Gln 
1               5                   10                  15      


Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser Ala 
            20                  25                  30          


Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
        35                  40                  45              


Arg Leu Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile Ser Leu 
    50                  55                  60                  


Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
65                  70                  75                  80  


Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Arg 
                85                  90                  95      


Ser Pro Ile Pro 
            100 


<210> 4
<211> 65
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile Ser Leu Glu Thr 
1               5                   10                  15      


Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val Thr Thr 
            20                  25                  30          


Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Arg Ser Pro 
        35                  40                  45              


Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val Gly Met Tyr Phe 
    50                  55                  60                  


Met 
65  


<210> 5
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Ser Gly Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr 
1               5                   10                  15      


Tyr Gln Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe 
            20                  25                  30          


Ser Ala Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg 
        35                  40                  45              


Leu Asn Arg Leu Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile 
    50                  55                  60                  


Ser Leu Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys 
65                  70                  75                  80  


Pro Val Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser 
                85                  90                  95      


Leu Arg Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val 
            100                 105                 110         


Gly Met Tyr Phe Met 
        115         


<210> 6
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Ser Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr Tyr 
1               5                   10                  15      


Gln Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser 
            20                  25                  30          


Ala Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu 
        35                  40                  45              


Asn Arg Leu Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile Ser 
    50                  55                  60                  


Leu Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro 
65                  70                  75                  80  


Val Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu 
                85                  90                  95      


Arg Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val Gly 
            100                 105                 110         


Met Tyr Phe Met 
        115     


<210> 7
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Ser Gly Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile Ser Leu 
1               5                   10                  15      


Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
            20                  25                  30          


Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Arg 
        35                  40                  45              


Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val Gly Met 
    50                  55                  60                  


Tyr Phe Met 
65          


<210> 8
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Ser Gly Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr 
1               5                   10                  15      


Tyr Gln Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe 
            20                  25                  30          


Ser Ala Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg 
        35                  40                  45              


Leu Asn Arg Leu Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile 
    50                  55                  60                  


Ser Leu Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys 
65                  70                  75                  80  


Pro Val Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser 
                85                  90                  95      


Leu Arg Ser Pro Ile Pro 
            100         


<210> 9
<211> 140
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Gly Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr Tyr 
1               5                   10                  15      


Gln Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser 
            20                  25                  30          


Ala Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu 
        35                  40                  45              


Asn Arg Leu Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile Ser 
    50                  55                  60                  


Leu Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro 
65                  70                  75                  80  


Val Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu 
                85                  90                  95      


Arg Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val Gly 
            100                 105                 110         


Met Tyr Phe Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln 
        115                 120                 125             


Lys Ile Glu Trp His Glu His His His His His His 
    130                 135                 140 


<210> 10
<211> 133
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Met Arg Gly Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      


Ser Gly Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr 
            20                  25                  30          


Tyr Gln Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe 
        35                  40                  45              


Ser Ala Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg 
    50                  55                  60                  


Leu Asn Arg Leu Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile 
65                  70                  75                  80  


Ser Leu Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys 
                85                  90                  95      


Pro Val Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser 
            100                 105                 110         


Leu Arg Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val 
        115                 120                 125             


Gly Met Tyr Phe Met 
    130             


<210> 11
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Met Ser Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr 
1               5                   10                  15      


Tyr Gln Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe 
            20                  25                  30          


Ser Ala Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg 
        35                  40                  45              


Leu Asn Arg Leu Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile 
    50                  55                  60                  


Ser Leu Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys 
65                  70                  75                  80  


Pro Val Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser 
                85                  90                  95      


Leu Arg Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val 
            100                 105                 110         


Gly Met Tyr Phe Met 
        115         


<210> 12
<211> 83
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Met Arg Gly Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      


Ser Gly Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile Ser Leu 
            20                  25                  30          


Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
        35                  40                  45              


Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Arg 
    50                  55                  60                  


Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val Gly Met 
65                  70                  75                  80  


Tyr Phe Met 
            


<210> 13
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Met Arg Gly Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      


Ser Gly Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr 
            20                  25                  30          


Tyr Gln Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe 
        35                  40                  45              


Ser Ala Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg 
    50                  55                  60                  


Leu Asn Arg Leu Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile 
65                  70                  75                  80  


Ser Leu Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys 
                85                  90                  95      


Pro Val Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser 
            100                 105                 110         


Leu Arg Ser Pro Ile Pro 
        115             


<210> 14
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Met Gly Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr 
1               5                   10                  15      


Tyr Gln Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe 
            20                  25                  30          


Ser Ala Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg 
        35                  40                  45              


Leu Asn Arg Leu Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile 
    50                  55                  60                  


Ser Leu Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys 
65                  70                  75                  80  


Pro Val Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser 
                85                  90                  95      


Leu Arg Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val 
            100                 105                 110         


Gly Met Tyr Phe Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala 
        115                 120                 125             


Gln Lys Ile Glu Trp His Glu His His His His His His 
    130                 135                 140     


<210> 15
<211> 393
<212> DNA
<213> Homo sapiens

<400> 15
atggatgtcc tctttgtagc catctttgct gtgccactta tcctgggaca agaatatgag       60

gatgaagaaa gactgggaga ggatgaatat tatcaggtgg tctattatta tacagtcacc      120

cccagttatg atgactttag tgcagatttc accattgatt actccatatt tgagtcagag      180

gacaggctga acaggttgga taaggacata acagaagcaa tagagactac cattagtctt      240

gaaacagcac gtgcagacca tccgaagcct gtaactgtga aaccagtaac aacggaacct      300

agtccagatc tgaacgatgc cgtgtccagt ttgcgaagtc ctattcccct cctcctgtcg      360

tgtgcctttg ttcaggtggg gatgtatttc atg                                   393


<210> 16
<211> 345
<212> DNA
<213> Homo sapiens

<400> 16
caagaatatg aggatgaaga aagactggga gaggatgaat attatcaggt ggtctattat       60

tatacagtca cccccagtta tgatgacttt agtgcagatt tcaccattga ttactccata      120

tttgagtcag aggacaggct gaacaggttg gataaggaca taacagaagc aatagagact      180

accattagtc ttgaaacagc acgtgcagac catccgaagc ctgtaactgt gaaaccagta      240

acaacggaac ctagtccaga tctgaacgat gccgtgtcca gtttgcgaag tcctattccc      300

ctcctcctgt cgtgtgcctt tgttcaggtg gggatgtatt tcatg                      345


<210> 17
<211> 300
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 17
caagaatatg aggatgaaga aagactggga gaggatgaat attatcaggt ggtctattat       60

tatacagtca cccccagtta tgatgacttt agtgcagatt tcaccattga ttactccata      120

tttgagtcag aggacaggct gaacaggttg gataaggaca taacagaagc aatagagact      180

accattagtc ttgaaacagc acgtgcagac catccgaagc ctgtaactgt gaaaccagta      240

acaacggaac ctagtccaga tctgaacgat gccgtgtcca gtttgcgaag tcctattccc      300


<210> 18
<211> 195
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 18
gataaggaca taacagaagc aatagagact accattagtc ttgaaacagc acgtgcagac       60

catccgaagc ctgtaactgt gaaaccagta acaacggaac ctagtccaga tctgaacgat      120

gccgtgtcca gtttgcgaag tcctattccc ctcctcctgt cgtgtgcctt tgttcaggtg      180

gggatgtatt tcatg                                                       195


<210> 19
<211> 399
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 19
atgcgaggtt cacatcatca tcatcatcat gaaaatttat attttcaatc aggtcaagaa       60

tatgaagatg aagaacgatt aggtgaagat gaatattatc aagtagttta ttactatact      120

gtaacaccaa gttatgacga ttttagtgct gatttcacaa ttgattattc aatttttgaa      180

tcagaggatc gattaaaccg tttagataaa gatattacag aggcaattga aacaacaatt      240

agtctggaaa cagcacgtgc tgatcatcca aagccagtaa cagttaagcc agttacaaca      300

gaacctagtc ctgaccttaa tgatgcagta agcagtcttc gttcaccaat cccacttcta      360

ctgtcatgtg catttgttca agttggtatg tattttatg                             399


<210> 20
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 20
atgagtcaag aatatgaaga tgaagaacgt ttaggtgaag atgaatatta tcaggttgtt       60

tactactaca ctgtaactcc aagctatgac gacttcagtg ctgacttcac catcgactac      120

agcatttttg agtcagaaga tcgtttaaac cgtcttgaca aagacatcac cgaagcaatc      180

gaaaccacca tttccctgga aacagctcgt gctgatcacc cgaaaccagt aaccgttaaa      240

ccggtgacta ctgaaccgtc tccggacctg aacgacgctg tgtcttcttt gcgttctccg      300

attcctctgc tgctgtcctg tgcattcgtt caggttggca tgtacttcat g               351


<210> 21
<211> 249
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 21
atgcgaggtt cacatcatca tcatcatcat gaaaatttat attttcaatc aggtgataaa       60

gatattacag aggcaattga aacaacaatt agtctggaaa cagcacgtgc tgatcatcca      120

aagccagtaa cagttaagcc agttacaaca gaacctagtc ctgaccttaa tgatgcagta      180

agcagtcttc gttcaccaat cccacttcta ctgtcatgtg catttgttca agttggtatg      240

tattttatg                                                              249


<210> 22
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 22
atgcgaggtt cacatcatca tcatcatcat gaaaatttat attttcaatc aggtcaagaa       60

tatgaagatg aagaacgatt aggtgaagat gaatattatc aagtagttta ttactatact      120

gtaacaccaa gttatgacga ttttagtgct gatttcacaa ttgattattc aatttttgaa      180

tcagaggatc gattaaaccg tttagataaa gatattacag aggcaattga aacaacaatt      240

agtctggaaa cagcacgtgc tgatcatcca aagccagtaa cagttaagcc agttacaaca      300

gaacctagtc ctgaccttaa tgatgcagta agcagtcttc gttcaccaat ccca            354


<210> 23
<211> 423
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 23
atgggtcaag aatatgaaga tgaagaacga ttaggtgaag atgaatatta tcaagtagtt       60

tattactata ctgtaacacc aagttatgac gattttagtg ctgatttcac aattgattat      120

tcaatttttg aatcagagga tcgattaaac cgtttagata aagatattac agaggcaatt      180

gaaacaacaa ttagtctgga aacagcacgt gctgatcatc caaagccagt aacagttaag      240

ccagttacaa cagaacctag tcctgacctt aatgatgcag taagcagtct tcgttcacca      300

atcccacttc tactgtcatg tgcatttgtt caagttggta tgtattttat gggtagttca      360

ggtttgaatg atatctttga agctcaaaaa attgagtggc acgagcatca tcatcatcat      420

cat                                                                    423


<210> 24
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Met Asp Val Leu Phe Ile Ala Leu Leu Val Ala Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Asp His Glu Glu Gln Leu Glu Glu Gly Asp Tyr Tyr Gln 
            20                  25                  30          


Val Ala Tyr Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp Phe Ser 
        35                  40                  45              


Val Asn Phe Thr Val Asp Tyr Ser Val Phe Glu Ser Glu Asp Arg Leu 
    50                  55                  60                  


Asn Arg Leu Asn Lys Glu Val Thr Thr Thr Glu Ala Val Glu Thr Thr 
65                  70                  75                  80  


Ala Ser Ser Tyr Ser Leu His Thr Glu Leu Met Asp Pro Gln Asn Pro 
                85                  90                  95      


Val Thr Thr Lys Pro Val Thr Thr Glu Pro Val Thr Thr Glu Pro Val 
            100                 105                 110         


Thr Thr Glu Pro Gln Ser Pro Asn Gln Asn Asp Ala Met Ser Thr Leu 
        115                 120                 125             


Gln Ser Pro Val Ser Cys Phe Leu Leu Trp Thr Leu Leu Gln Gly Gly 
    130                 135                 140                 


Val His Phe Met 
145             


<210> 25
<211> 134
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Ser Gly Gln Glu Tyr Asp His Glu Glu Gln Leu Glu Glu Gly Asp Tyr 
1               5                   10                  15      


Tyr Gln Val Ala Tyr Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp 
            20                  25                  30          


Phe Ser Val Asn Phe Thr Val Asp Tyr Ser Val Phe Glu Ser Glu Asp 
        35                  40                  45              


Arg Leu Asn Arg Leu Asn Lys Glu Val Thr Thr Thr Glu Ala Val Glu 
    50                  55                  60                  


Thr Thr Ala Ser Ser Tyr Ser Leu His Thr Glu Leu Met Asp Pro Gln 
65                  70                  75                  80  


Asn Pro Val Thr Thr Lys Pro Val Thr Thr Glu Pro Val Thr Thr Glu 
                85                  90                  95      


Pro Val Thr Thr Glu Pro Gln Ser Pro Asn Gln Asn Asp Ala Met Ser 
            100                 105                 110         


Thr Leu Gln Ser Pro Val Ser Cys Phe Leu Leu Trp Thr Leu Leu Gln 
        115                 120                 125             


Gly Gly Val His Phe Met 
    130                 


<210> 26
<211> 157
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 26
Gly Gln Glu Tyr Asp His Glu Glu Gln Leu Glu Glu Gly Asp Tyr Tyr 
1               5                   10                  15      


Gln Val Ala Tyr Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp Phe 
            20                  25                  30          


Ser Val Asn Phe Thr Val Asp Tyr Ser Val Phe Glu Ser Glu Asp Arg 
        35                  40                  45              


Leu Asn Arg Leu Asn Lys Glu Val Thr Thr Thr Glu Ala Val Glu Thr 
    50                  55                  60                  


Thr Ala Ser Ser Tyr Ser Leu His Thr Glu Leu Met Asp Pro Gln Asn 
65                  70                  75                  80  


Pro Val Thr Thr Lys Pro Val Thr Thr Glu Pro Val Thr Thr Glu Pro 
                85                  90                  95      


Val Thr Thr Glu Pro Gln Ser Pro Asn Gln Asn Asp Ala Met Ser Thr 
            100                 105                 110         


Leu Gln Ser Pro Val Ser Cys Phe Leu Leu Trp Thr Leu Leu Gln Gly 
        115                 120                 125             


Gly Val His Phe Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala 
    130                 135                 140                 


Gln Lys Ile Glu Trp His Glu His His His His His His 
145                 150                 155         


<210> 27
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Met Arg Gly Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      


Ser Gly Gln Glu Tyr Asp His Glu Glu Gln Leu Glu Glu Gly Asp Tyr 
            20                  25                  30          


Tyr Gln Val Ala Tyr Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp 
        35                  40                  45              


Phe Ser Val Asn Phe Thr Val Asp Tyr Ser Val Phe Glu Ser Glu Asp 
    50                  55                  60                  


Arg Leu Asn Arg Leu Asn Lys Glu Val Thr Thr Thr Glu Ala Val Glu 
65                  70                  75                  80  


Thr Thr Ala Ser Ser Tyr Ser Leu His Thr Glu Leu Met Asp Pro Gln 
                85                  90                  95      


Asn Pro Val Thr Thr Lys Pro Val Thr Thr Glu Pro Val Thr Thr Glu 
            100                 105                 110         


Pro Val Thr Thr Glu Pro Gln Ser Pro Asn Gln Asn Asp Ala Met Ser 
        115                 120                 125             


Thr Leu Gln Ser Pro Val Ser Cys Phe Leu Leu Trp Thr Leu Leu Gln 
    130                 135                 140                 


Gly Gly Val His Phe Met 
145                 150 


<210> 28
<211> 158
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 28
Met Gly Gln Glu Tyr Asp His Glu Glu Gln Leu Glu Glu Gly Asp Tyr 
1               5                   10                  15      


Tyr Gln Val Ala Tyr Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp 
            20                  25                  30          


Phe Ser Val Asn Phe Thr Val Asp Tyr Ser Val Phe Glu Ser Glu Asp 
        35                  40                  45              


Arg Leu Asn Arg Leu Asn Lys Glu Val Thr Thr Thr Glu Ala Val Glu 
    50                  55                  60                  


Thr Thr Ala Ser Ser Tyr Ser Leu His Thr Glu Leu Met Asp Pro Gln 
65                  70                  75                  80  


Asn Pro Val Thr Thr Lys Pro Val Thr Thr Glu Pro Val Thr Thr Glu 
                85                  90                  95      


Pro Val Thr Thr Glu Pro Gln Ser Pro Asn Gln Asn Asp Ala Met Ser 
            100                 105                 110         


Thr Leu Gln Ser Pro Val Ser Cys Phe Leu Leu Trp Thr Leu Leu Gln 
        115                 120                 125             


Gly Gly Val His Phe Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu 
    130                 135                 140                 


Ala Gln Lys Ile Glu Trp His Glu His His His His His His 
145                 150                 155             


<210> 29
<211> 450
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 29
atgcgtggta gccatcatca tcatcaccat gaaaatctgt attttcagag cggccaagaa       60

tatgatcacg aagaacagct ggaagagggt gattattatc aggttgccta ttattattat      120

accgtgaccc cgaactatga tgattttagc gtgaatttca ccgtggacta tagcgttttt      180

gaaagcgaag atcgtctgaa tcgcctgaat aaagaagtta ccaccaccga agcagttgaa      240

accaccgcca gcagctatag cctgcatacc gaactgatgg acccgcagaa tccggtgacc      300

accaaaccgg ttacaaccga acctgttacc acggaaccgg tgacgacaga accgcagagc      360

ccgaatcaga atgatgcaat gagcaccctg cagagtccgg ttagctgttt tctgctgtgg      420

acactgctgc aaggtggtgt tcattttatg                                       450


<210> 30
<211> 474
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 30
atgggtcaag aatatgatca cgaagaacag ctggaagagg gtgattatta tcaggttgcc       60

tattattatt ataccgtgac cccgaactat gatgatttta gcgtgaattt caccgtggac      120

tatagcgttt ttgaaagcga agatcgtctg aatcgcctga ataaagaagt taccaccacc      180

gaagcagttg aaaccaccgc cagcagctat agcctgcata ccgaactgat ggacccgcag      240

aatccggtga ccaccaaacc ggttacaacc gaacctgtta ccacggaacc ggtgacgaca      300

gaaccgcaga gcccgaatca gaatgatgca atgagcaccc tgcagagtcc ggttagctgt      360

tttctgctgt ggacactgct gcaaggtggt gttcatttta tgggatcctc tggcctgaac      420

gacatcttcg aagcccagaa aatcgagtgg cacgagcatc atcatcatca tcat            474


<210> 31
<211> 100
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Met Asn Ile Phe Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Val Leu Glu Glu Asp Asp Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp Phe Gly Val 
        35                  40                  45              


Asn Phe Thr Val Asp Tyr Ser Leu Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Glu Val Met Glu Pro Ala Glu Thr Thr Ile Ser Arg 
65                  70                  75                  80  


Glu Thr Glu His Ala Asp His Gln Lys Pro Val Thr Leu Lys Pro Val 
                85                  90                  95      


Thr Met Glu Pro 
            100 


<210> 32
<211> 151
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 32
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Gly Glu Gly Leu Glu Glu Asp Asp Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp Phe Gly Ala 
        35                  40                  45              


Asn Phe Thr Val Asp Tyr Ser Met Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Glu Val Arg Glu Ala Ala Glu Thr Thr Ile Ser His 
65                  70                  75                  80  


Glu Thr Glu Gly Ala Asp Pro Gln Lys Pro Glu Thr Leu Lys Pro Met 
                85                  90                  95      


Thr Val Glu Pro Ile Leu Phe Ile His Glu Arg His Arg Glu Arg Glu 
            100                 105                 110         


Arg Gln Arg Gln Lys Gln Ala Pro His Lys Glu Pro Asp Ala His Lys 
        115                 120                 125             


Glu Pro Asp Ala Gly Leu Asn Pro Gly Ser Leu Asp Gln Gly Pro Ser 
    130                 135                 140                 


Arg Arg Gln Thr Leu Asn Arg 
145                 150     


<210> 33
<211> 131
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Gly Glu Glu Leu Glu Glu Asp Glu Tyr Tyr Gln 
            20                  25                  30          


Val Ile Tyr Tyr Tyr Thr Ile Thr Pro Ser Tyr Asp Glu Phe Gly Val 
        35                  40                  45              


Asn Phe Thr Val Asp Tyr Ser Met Phe Glu Ser Glu Asn Thr Val Asn 
    50                  55                  60                  


Arg Leu Asp Glu Lys Val Glu Ala Ser Glu Thr Thr Ile Ser Tyr Glu 
65                  70                  75                  80  


Thr Asp Arg Ala Asp His Gln Lys Pro Val Ile Glu Lys Pro Val Thr 
                85                  90                  95      


Met Glu Pro Gln Ser Pro Asp Leu Asn Asp Ala Val Ser Gly Leu Gln 
            100                 105                 110         


Ser Pro Gly Pro Leu Leu Leu Ser Trp Ala Leu Ile Gln Gly Val Met 
        115                 120                 125             


Tyr Phe Leu 
    130     


<210> 34
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Met Arg Gly Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      


Ser Gly 
        


<210> 35
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp 
1               5                   10                  15      


His Glu His His His His His His 
            20                  


<210> 36
<211> 91
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 36
gaaggagata tacatatgcg tggtagccat catcatcatc accatgaaaa tctgtatttt       60

cagagcggcc aagaatatga tcacgaagaa c                                      91


<210> 37
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 37
gtggtggtgg tgctcgagtg cggccgctta tcacataaaa tgaacaccac cttgc            55


<210> 38
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 38
gtttaacttt aagaaggaga tatacatatg ggtcaagaat atgatcacga a                51


<210> 39
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 39
ggcttcgaag atgtcgttca ggccagagga tcccataaaa tgaacaccac c                51


<210> 40
<211> 88
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 40
gaaggagata tacatatgcg aggttcacat catcatcatc atcatgaaaa tttatatttt       60

caatcaggtc aagaatatga agatgaag                                          88


<210> 41
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 41
gtgctcgacg atatcgcggc cgcttatcac ataaaataca tacc                        44


<210> 42
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 42
gtggtgctcg acgatatcgc ggccgcttat catgggattg gtgaacg                     47


<210> 43
<211> 95
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 43
ctttaagaag gagatataca tatgcgaggt tcacatcatc atcatcatca tgaaaattta       60

tattttcaat caggtgataa agatattaca gaggc                                  95


<210> 44
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 44
ctttaagaag gagatataca tatgagtcaa gaatatgaag                             40


<210> 45
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 45
gctcgacgat atcgcggccg cttatcacat gaagtacatg cc                          42


<210> 46
<211> 131
<212> PRT
<213> Pan troglodytes

<400> 46
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser Ala 
        35                  40                  45              


Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Asp Ile Thr Glu Ala Val Glu Thr Thr Ile Ser Leu 
65                  70                  75                  80  


Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
                85                  90                  95      


Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Arg 
            100                 105                 110         


Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val Gly Met 
        115                 120                 125             


Tyr Phe Met 
    130     


<210> 47
<211> 132
<212> PRT
<213> Pan troglodytes

<400> 47
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser Ala 
        35                  40                  45              


Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Asp Ile Thr Glu Ala Val Glu Thr Thr Ile Ser Leu 
65                  70                  75                  80  


Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
                85                  90                  95      


Thr Thr Glu Pro Gln Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu 
            100                 105                 110         


Arg Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val Gly 
        115                 120                 125             


Met Tyr Phe Met 
    130         


<210> 48
<211> 131
<212> PRT
<213> Gorilla gorilla 

<400> 48
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser Ala 
        35                  40                  45              


Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Asp Ile Thr Glu Ala Val Glu Thr Thr Ile Ser Leu 
65                  70                  75                  80  


Glu Thr Ala Leu Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
                85                  90                  95      


Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Arg 
            100                 105                 110         


Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val Gly Met 
        115                 120                 125             


Tyr Phe Met 
    130     


<210> 49
<211> 131
<212> PRT
<213> Nomascus leucogenys

<400> 49
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser Ala 
        35                  40                  45              


Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Asp Val Thr Glu Ala Val Gly Thr Thr Ile Ser Leu 
65                  70                  75                  80  


Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
                85                  90                  95      


Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Arg 
            100                 105                 110         


Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Ala Gly Met 
        115                 120                 125             


Tyr Phe Met 
    130     


<210> 50
<211> 132
<212> PRT
<213> Macaca mulatta

<400> 50
Met Asp Ile Leu Phe Ala Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Arg Met Gly Glu Asp Glu Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser Ala 
        35                  40                  45              


Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Asp Thr Thr Glu Ala Val Gly Thr Thr Ile Ser Leu 
65                  70                  75                  80  


Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
                85                  90                  95      


Thr Thr Glu Pro Gln Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu 
            100                 105                 110         


Arg Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Ala Gly 
        115                 120                 125             


Met Tyr Phe Met 
    130         


<210> 51
<211> 132
<212> PRT
<213> Papio anubis

<400> 51
Met Asp Ile Leu Phe Ala Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Arg Met Gly Glu Asp Glu Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser Ala 
        35                  40                  45              


Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Asp Thr Thr Glu Ala Val Gly Thr Thr Ile Ser Leu 
65                  70                  75                  80  


Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
                85                  90                  95      


Thr Thr Glu Pro Gln Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu 
            100                 105                 110         


Arg Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Ala Gly 
        115                 120                 125             


Met Tyr Phe Met 
    130         


<210> 52
<211> 131
<212> PRT
<213> Chlorocebus sabaeus

<400> 52
Met Asp Ile Leu Phe Ala Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Arg Met Gly Glu Asp Glu Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser Ala 
        35                  40                  45              


Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Asp Thr Thr Glu Ala Val Gly Thr Thr Ile Ser Leu 
65                  70                  75                  80  


Glu Pro Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
                85                  90                  95      


Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Thr Leu Arg 
            100                 105                 110         


Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Ala Gly Met 
        115                 120                 125             


Tyr Phe Met 
    130     


<210> 53
<211> 129
<212> PRT
<213> Pongo abelii

<400> 53
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Lys Asp Trp Glu Arg Met Asn Leu Ser Gly 
            20                  25                  30          


Gly Leu Leu Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser Ala Asp 
        35                  40                  45              


Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn Arg 
    50                  55                  60                  


Leu Asp Lys Asp Ile Thr Glu Ala Val Glu Thr Thr Ile Ser Leu Glu 
65                  70                  75                  80  


Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val Thr 
                85                  90                  95      


Thr Glu Pro Ser Pro Asp Leu Lys Ala Val Ala Ser Leu Arg Ser Pro 
            100                 105                 110         


Ile Pro Leu Leu Leu Ser Cys Gly Val Val Gln Ala Gly Met Tyr Phe 
        115                 120                 125             


Met 
    


<210> 54
<211> 131
<212> PRT
<213> Callithrix jacchus

<400> 54
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Arg Leu Glu Glu Asp Glu Tyr Tyr Gln 
            20                  25                  30          


Val Ala Tyr Tyr Phe Thr Val Thr Pro Thr Tyr Asp Asp Phe Gly Ala 
        35                  40                  45              


Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Ser Leu Asp Lys Asp Thr Thr Glu Ala Val Gly Thr Thr Ile Arg Leu 
65                  70                  75                  80  


Gln Arg Ala Arg Glu Asp His Gln Lys Pro Ile Thr Val Lys Pro Val 
                85                  90                  95      


Ile Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Gln 
            100                 105                 110         


Ser Pro Ile Pro Leu Leu Leu Ser Cys Val Leu Val Gln Val Gly Met 
        115                 120                 125             


Tyr Phe Met 
    130     


<210> 55
<211> 132
<212> PRT
<213> Mustela putorius 

<400> 55
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Gln Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Gly Leu Glu Glu Asp Asp Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp Phe Ser Ala 
        35                  40                  45              


Asn Phe Thr Val Asp Tyr Ser Met Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Glu Val Arg Glu Ala Ala Glu Thr Thr Ile Ser His 
65                  70                  75                  80  


Glu Thr Glu Gly Ala His Thr Gln Lys Pro Glu Thr Val Lys Pro Met 
                85                  90                  95      


Thr Arg Glu Pro Gln Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu 
            100                 105                 110         


Gln Ser Pro Val Pro Leu Leu Leu Ser Trp Ala Leu Val Gln Gly Gly 
        115                 120                 125             


Met Tyr Phe Met 
    130         


<210> 56
<211> 131
<212> PRT
<213> Sus scrofa

<400> 56
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Gly Leu Glu Glu Asp Asp Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp Phe Gly Ala 
        35                  40                  45              


Asn Phe Thr Leu Asp Tyr Ser Val Phe Asp Ser Glu Asp Met Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Glu Glu Met Glu Ala Val Glu Thr Thr Ile Ser His 
65                  70                  75                  80  


Ala Thr Asp Gly Ala Asp His Gln Lys Pro Val Thr Met Lys Pro Met 
                85                  90                  95      


Thr Thr Glu Pro Ser Pro Asp Leu Asn Glu Ala Val Ser Ser Leu Gln 
            100                 105                 110         


Ser Pro Val Pro Leu Leu Leu Ser Trp Ala Leu Val Gln Gly Gly Met 
        115                 120                 125             


Tyr Phe Met 
    130     


<210> 57
<211> 143
<212> PRT
<213> Felis catus

<400> 57
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Gly Asp Glu Glu Gly Leu Glu Glu Asp Asp Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp Phe Gly Ala 
        35                  40                  45              


Asn Phe Thr Val Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Glu Val Arg Glu Gly Ala Glu Thr Thr Thr Ile Ser 
65                  70                  75                  80  


Arg Glu Thr Glu Leu Thr Asp His Gln Glu Pro Glu Thr Leu Lys Pro 
                85                  90                  95      


Met Thr Met Glu Pro Lys Thr Lys Arg Pro Met Asn Val Pro Ile Gln 
            100                 105                 110         


Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Gln Ser Pro Val Pro 
        115                 120                 125             


Leu Leu Leu Ser Trp Ala Leu Val Gln Gly Gly Met Tyr Phe Met 
    130                 135                 140             


<210> 58
<211> 132
<212> PRT
<213> Spermophilus tridecemlineatus 

<400> 58
Met Asp Val Leu Phe Val Ala Ile Leu Ala Met Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Gly Leu Thr Glu Asp Tyr Tyr Gln Val 
            20                  25                  30          


Ala Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp Phe Ser Ala Asn 
        35                  40                  45              


Phe Thr Ile Asp Tyr Ser Met Phe Glu Ser Glu Asp Arg Leu Asn Ser 
    50                  55                  60                  


Leu Asp Lys Glu Glu Thr Thr Gln Ala Val Glu Thr Thr Ile Ile Leu 
65                  70                  75                  80  


Lys Thr Glu His Ala Asp His Gln Lys Pro Val Thr Met Lys Ala Val 
                85                  90                  95      


Thr Met Glu Thr Gln Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu 
            100                 105                 110         


Gln Ser Pro Val Ser Leu Leu Leu Ser Trp Val Leu Leu Gln Gly Gly 
        115                 120                 125             


Met Tyr Phe Met 
    130         


<210> 59
<211> 143
<212> PRT
<213> Spermophilus tridecemlineatus 

<400> 59
Met Asp Val Leu Phe Val Ala Ile Leu Ala Met Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Gly Leu Thr Glu Asp Tyr Tyr Gln Val 
            20                  25                  30          


Ala Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp Phe Ser Ala Asn 
        35                  40                  45              


Phe Thr Ile Asp Tyr Ser Met Phe Glu Ser Glu Asp Arg Leu Asn Ser 
    50                  55                  60                  


Leu Asp Lys Glu Glu Thr Thr Gln Ala Val Glu Thr Thr Ile Ile Leu 
65                  70                  75                  80  


Lys Thr Glu His Ala Asp His Gln Lys Pro Val Thr Met Lys Ala Val 
                85                  90                  95      


Thr Met Glu Thr Val Arg Leu Leu Arg Val Leu Met Glu Arg Asn Gln 
            100                 105                 110         


Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Gln Ser Pro Val Ser 
        115                 120                 125             


Leu Leu Leu Ser Trp Val Leu Leu Gln Gly Gly Met Tyr Phe Met 
    130                 135                 140             


<210> 60
<211> 144
<212> PRT
<213> Loxodonta africana

<400> 60
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asn Glu Glu Ile Leu Glu Glu Asp Asp Tyr Tyr Gln 
            20                  25                  30          


Val Ile Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp Leu Gly Ala 
        35                  40                  45              


Asn Phe Thr Val Asp Tyr Ser Val Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Asp Val Thr Glu Ala Val Glu Thr Asn Ile Asn Leu 
65                  70                  75                  80  


Glu Thr Glu Arg Gln Asp His Leu Lys Pro Val Thr Arg Lys Pro Val 
                85                  90                  95      


Thr Met Glu Pro Pro Ser Val Leu Ser Gln Ser Leu Asn Thr Thr Leu 
            100                 105                 110         


Gln Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Gln Ser Pro Val 
        115                 120                 125             


Pro Leu Ile Leu Ser Trp Ala Leu Ile Gln Gly Gly Ile Tyr Phe Thr 
    130                 135                 140                 


<210> 61
<211> 132
<212> PRT
<213> Ailuropoda melanoleuca

<400> 61
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Gly Leu Glu Glu Asp Asp Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp Phe Gly Ala 
        35                  40                  45              


Asn Phe Thr Val Asp Tyr Ser Met Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Glu Val Arg Glu Glu Ala Glu Ser Thr Thr Ser His 
65                  70                  75                  80  


Glu Thr Glu Gly Thr Asp Gly Gln Lys Pro Gly Thr Leu Lys Pro Met 
                85                  90                  95      


Thr Val Glu Pro Gln Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu 
            100                 105                 110         


Gln Ser Pro Val Pro Leu Leu Leu Ser Trp Ala Leu Val Gln Gly Gly 
        115                 120                 125             


Met Tyr Phe Met 
    130         


<210> 62
<211> 131
<212> PRT
<213> Ovis aries

<400> 62
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Gly Glu Glu Leu Glu Glu Asp Asp Tyr Tyr Gln 
            20                  25                  30          


Val Ile Tyr Tyr Tyr Thr Ile Thr Pro Asn Tyr Asp Asp Phe Gly Val 
        35                  40                  45              


Asn Phe Thr Val Asp Tyr Ser Met Phe Glu Ser Glu Asn Thr Val Asn 
    50                  55                  60                  


Arg Leu Asp Asp Lys Val Glu Thr Ser Glu Thr Thr Ile Ser Tyr Glu 
65                  70                  75                  80  


Thr Asp Arg Ala Asp His Gln Lys Pro Val Thr Glu Lys Pro Val Thr 
                85                  90                  95      


Met Glu Pro Gln Ser Pro Asp Leu Asn Asp Ala Val Ser Gly Leu Gln 
            100                 105                 110         


Ser Pro Gly Pro Leu Leu Leu Ser Trp Ala Leu Val Gln Gly Met Met 
        115                 120                 125             


Tyr Phe Leu 
    130     


<210> 63
<211> 131
<212> PRT
<213> Bos taurus

<400> 63
Met Asp Val Leu Phe Val Ala Ile Leu Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Gly Glu Glu Leu Glu Glu Asp Glu Tyr Tyr Gln 
            20                  25                  30          


Val Ile Tyr Tyr Tyr Thr Ile Thr Pro Ser Tyr Asp Glu Phe Gly Val 
        35                  40                  45              


Asn Phe Thr Val Asp Tyr Ser Met Phe Glu Ser Glu Asn Thr Val Asn 
    50                  55                  60                  


Arg Leu Asp Glu Lys Val Glu Ala Ser Glu Thr Thr Ile Ser Tyr Glu 
65                  70                  75                  80  


Thr Asp Arg Ala Asp His Gln Lys Pro Val Ile Glu Lys Pro Val Thr 
                85                  90                  95      


Met Glu Pro Gln Ser Pro Asp Leu Asn Asp Ala Val Ser Gly Leu Gln 
            100                 105                 110         


Ser Pro Gly Pro Leu Leu Leu Ser Trp Ala Leu Ile Gln Gly Val Met 
        115                 120                 125             


Tyr Phe Leu 
    130     


<210> 64
<211> 127
<212> PRT
<213> Oryctolagus cuniculus

<400> 64
Ala Ile Leu Ala Val Pro Leu Ile Leu Gly Gln Glu Tyr Glu Asp Glu 
1               5                   10                  15      


Glu Gly Leu Glu Glu Glu Asp Tyr Tyr Gln Val Ala Tyr Tyr Tyr Thr 
            20                  25                  30          


Ile Thr Pro Asn Tyr Asp Asp Phe Gly Val Asn Phe Thr Ile Asp Tyr 
        35                  40                  45              


Ser Thr Phe Glu Leu Glu Asp Arg Leu Gly Thr Leu Asp Lys Glu Val 
    50                  55                  60                  


Thr Thr Glu Ala Val Glu Thr Thr Ile Ser Leu Gly Thr Glu Gly Ala 
65                  70                  75                  80  


Asp His Thr Lys Pro Val Thr Val Lys Pro Thr Thr Met Asp Thr Gln 
                85                  90                  95      


Ser Pro Val Leu Asp Gly Ala Val Ser Gly Leu Arg Asn Pro Val Ser 
            100                 105                 110         


Leu Leu Leu Pro Cys Ile Leu Val Gln Gly Gly Met Tyr Phe Met 
        115                 120                 125         


<210> 65
<211> 144
<212> PRT
<213> Myotis lucifugus

<400> 65
Met Asp Val Leu Leu Ala Ala Ile Leu Ala Val Pro Leu Val Leu Gly 
1               5                   10                  15      


Gln Ile Tyr Glu Asp Glu Glu Gly Leu Glu Glu Asp Tyr Tyr Tyr Gln 
            20                  25                  30          


Met Met Tyr Asn Tyr Thr Val Thr Pro Thr Tyr Asp Pro Asp Tyr Phe 
        35                  40                  45              


Gly Ala Asn Phe Thr Val Asp Tyr Ser Ile Phe Glu Leu Glu Asp Arg 
    50                  55                  60                  


Leu Asn Arg Leu Asp Lys Glu Val Thr Glu Ala Glu Glu Thr Thr Ile 
65                  70                  75                  80  


Ile His Glu Thr Glu Arg Val Asp His Gln Arg Pro Val Thr Val Lys 
                85                  90                  95      


Ser Val Thr Val Glu Pro Val Thr Met Glu Pro Val Thr Met Glu Pro 
            100                 105                 110         


Gln Ser Pro Asp Met Asn His Ala Val Ser Ser Leu Gln Ser Pro Val 
        115                 120                 125             


Ser Leu Leu Leu Ser Trp Thr Leu Leu Gln Glu Trp Met Tyr Phe Met 
    130                 135                 140                 


<210> 66
<211> 131
<212> PRT
<213> Cavia porcellus

<400> 66
Met Asp Val Leu Phe Thr Ala Ile Leu Val Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Leu Val Gln Asp Asp Tyr Tyr Gln Val 
            20                  25                  30          


Ile Tyr Tyr Tyr Thr Val Thr Pro Thr Tyr Asp Asp Phe Asn Val Asn 
        35                  40                  45              


Phe Thr Ile Asp Tyr Ser Met Phe Glu Ser Glu Asp Lys Leu Asn Asn 
    50                  55                  60                  


Ser Phe Lys Glu Val Thr Thr Lys Ala Val Glu Thr Thr Ile Ser Leu 
65                  70                  75                  80  


Gln Thr Gln Pro Glu Asp Asn Glu Asn Pro Val Thr Thr Lys Pro Met 
                85                  90                  95      


Thr Met Ala Thr Gln Ser Pro Asp Leu Asn Ser Ala Thr Val Ser Asn 
            100                 105                 110         


Leu Pro Ser Pro Val Pro Leu Leu Leu Leu Trp Ala Leu Val Gln Gly 
        115                 120                 125             


Gly Met Phe  
    130             


<210> 67
<211> 148
<212> PRT
<213> Mus musculus

<400> 67
Met Asp Val Leu Phe Ile Ala Leu Leu Val Ala Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Asp His Glu Glu Gln Leu Glu Glu Gly Asp Tyr Tyr Gln 
            20                  25                  30          


Val Ala Tyr Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp Phe Ser 
        35                  40                  45              


Val Asn Phe Thr Val Asp Tyr Ser Val Phe Glu Ser Glu Asp Arg Leu 
    50                  55                  60                  


Asn Arg Leu Asn Lys Glu Val Thr Thr Thr Glu Ala Val Glu Thr Thr 
65                  70                  75                  80  


Ala Ser Ser Tyr Ser Leu His Thr Glu Leu Met Asp Pro Gln Asn Pro 
                85                  90                  95      


Val Thr Thr Lys Pro Val Thr Thr Glu Pro Val Thr Thr Glu Pro Val 
            100                 105                 110         


Thr Thr Glu Pro Gln Ser Pro Asn Gln Asn Asp Ala Met Ser Thr Leu 
        115                 120                 125             


Gln Ser Pro Val Ser Cys Phe Leu Leu Trp Thr Leu Leu Gln Gly Gly 
    130                 135                 140                 


Val His Phe Met 
145             


<210> 68
<211> 152
<212> PRT
<213> Rattus norvegicus

<400> 68
Met Asp Val Leu Phe Ile Ala Leu Leu Val Ala Pro Leu Val Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Gln Leu Glu Glu Val Asp Tyr Tyr Gln 
            20                  25                  30          


Val Ser Tyr Tyr Tyr Tyr Thr Val Thr Pro Asn Tyr Asp Asp Phe Asn 
        35                  40                  45              


Val Asn Phe Thr Val Asp Tyr Ser Ala Phe Glu Ser Glu Asp Arg Leu 
    50                  55                  60                  


Asn Ser Leu Asn Glu Glu Val Thr Thr Thr Glu Ala Val Glu Thr Ser 
65                  70                  75                  80  


Ala Ser Ser Tyr Ser Leu His Thr Glu Pro Val Asp His Gln Asn Pro 
                85                  90                  95      


Val Thr Thr Lys Pro Val Thr Met Lys Pro Val Thr Thr Lys Pro Val 
            100                 105                 110         


Thr Thr Lys Gln Val Thr Thr Lys Gln Val Thr Thr Glu Ser Val Ser 
        115                 120                 125             


Gln Met Gly Ile Glu Glu Glu Gly Asn Met Ala Ser Leu Thr Gln Thr 
    130                 135                 140                 


Asp Pro Arg Thr Ser Asp Leu Gln 
145                 150         


