                         SEQUENCE LISTING

<110>  SHEN, Weiqun
       TAN, Xiangyang
       LIU, Jianning
 
<120>  ANTI-IL-17A ANTIBODIES AND USE THEREOF

<130>  0073-PA-002

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  1

Gly Phe Thr Phe Ser Thr Tyr Gly 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  2

Ile Asn His Asn Gly Gly Ser Thr 
1               5               


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  3

Ala Arg Asp Pro Arg His Asp Gly Tyr Phe Phe Asp Tyr 
1               5                   10              


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1

<400>  4

Glu Asp Phe Tyr Asp Arg 
1               5       


<210>  5
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2

<400>  5

Gly Ala Thr 
1           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  6

Gln Gln Tyr Trp Ser Val Pro Trp Thr 
1               5                   


<210>  7
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Ile Ile Asn His Asn Gly Gly Ser Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Leu His 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg His Asp Gly Tyr Phe Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  8

Asp Ile Gln Met Thr Gln Ser Ser Pro Ser Phe Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asp Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Lys Asp Tyr Thr Leu Asp Ile Asn Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  470
<212>  PRT
<213>  Mus musculus

<400>  9

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Thr Tyr Gly Met Ser Trp Val Arg Gln Thr 
    50                  55                  60                  


Pro Asp Lys Arg Leu Glu Leu Val Ala Ile Ile Asn His Asn Gly Gly 
65                  70                  75                  80  


Ser Thr Phe Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg 
                85                  90                  95      


Asp Asn Ala Lys Asn Thr Leu His Leu Gln Met Ser Ser Leu Lys Ser 
            100                 105                 110         


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Pro Arg His Asp Gly 
        115                 120                 125             


Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Leu Gly 
465                 470 


<210>  10
<211>  234
<212>  PRT
<213>  Mus musculus

<400>  10

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Ser Pro Ser Phe Ser 
            20                  25                  30          


Val Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp 
        35                  40                  45              


Ile Tyr Asp Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Lys Asp Tyr Thr Leu Asp Ile Asn 
                85                  90                  95      


Ser Leu Gln Thr Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp 
            100                 105                 110         


Ser Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  11
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain 6665; PP10760 H; PP10761 H; PP10762 H

<400>  11

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Thr Tyr Gly Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Leu Val Ser Ile Ile Asn His Asn Gly Gly 
65                  70                  75                  80  


Ser Thr Phe Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Arg His Asp Gly 
        115                 120                 125             


Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Leu Gly 
465                 470 


<210>  12
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH6665; PP10760 VH; PP10761 VH; PP10762 VH

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Asn His Asn Gly Gly Ser Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg His Asp Gly Tyr Phe Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  13
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain 6665 nucleotide; PP10760 H nucleotide; PP10761 H 
       nucleotide; PP10762 H nucleotide

<400>  13
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca actggtggag tccggcggag gtctggtgca gcccggtggc      120

agcctgaggc tgtcatgcgc agccagcggc ttcaccttca gcacctacgg catgagctgg      180

gtgaggcagg cacccggcaa gggcctggag ctggtgagca tcatcaacca caacggcggc      240

agtacctttt accccgacag cgtgaagggc aggttcacca tcagcaggga caacagcaag      300

aacaccctgt acctgcagat gaactcactg agggcagagg acaccgccgt gtactactgc      360

gccagggacc ccaggcatga cgggtacttc ttcgactact ggggccaggg caccctggtg      420

acagttagct ctgctagcac caagggcccc agcgtgtttc ctctcgctcc ctgcagccgg      480

agcacatccg agagcaccgc tgctctgggc tgtctcgtga aggactactt ccctgaaccc      540

gtcaccgtca gctggaatag cggcgccctg acatccggcg tccacacatt ccccgctgtc      600

ctgcagagca gcggcctgta cagcctgagc tccgtggtca ccgtgcctag cagcagcctg      660

ggaacaaaga cctacacctg caacgtggac cataagccct ccaacaccaa ggtggacaag      720

cgggtggaat ccaagtatgg acccccctgt cctccttgcc ctgctcctga atttctcgga      780

ggcccctccg tcttcctgtt tccccccaag cccaaggaca ccctgatgat ctcccggaca      840

cccgaagtca cctgcgtcgt ggtggatgtc agccaggaag atcccgaggt gcagttcaac      900

tggtacgtgg acggagtgga ggtgcataac gccaaaacca agcccaggga agagcagttc      960

aacagcacct atcgggtcgt gtccgtgctc accgtcctgc atcaggattg gctcaacggc     1020

aaggagtaca agtgcaaggt gtccaacaag ggcctgccct cctccatcga gaagaccatc     1080

tccaaggcta agggccaacc tcgggagccc caagtgtata ccctccctcc cagccaggag     1140

gagatgacca agaatcaagt gagcctgacc tgcctcgtga agggatttta cccctccgac     1200

atcgctgtgg aatgggaaag caatggccaa cctgagaaca actacaagac cacacccccc     1260

gtgctggact ccgatggctc cttcttcctg tacagcaggc tgaccgtgga caaatcccgg     1320

tggcaagagg gaaacgtgtt cagctgctcc gtgatgcacg aggctctcca caaccactac     1380

acccagaaga gcctctccct gagcctcggc tagtaa                               1416


<210>  14
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain 6666; PP10763 H; PP10764 H; PP10765 H

<400>  14

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Thr Tyr Gly Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Leu Val Ala Ile Ile Asn His Asn Gly Gly 
65                  70                  75                  80  


Ser Thr Phe Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Arg His Asp Gly 
        115                 120                 125             


Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Leu Gly 
465                 470 


<210>  15
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH6666; PP10763 VH; PP10764 VH; PP10765 VH

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Ile Ile Asn His Asn Gly Gly Ser Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg His Asp Gly Tyr Phe Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  16
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain 6666 nucleotide; PP10763 H nucleotide; PP10764 H 
       nucleotide; PP10765 H nucleotide

<400>  16
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca actggtggag tccggcggag gtctggtgca gcccggtggc      120

agcctgaggc tgtcatgcgc agccagcggc ttcaccttca gcacctacgg catgagctgg      180

gtgaggcagg cacccggcaa gggcctggag ctggtggcaa tcatcaacca caacggcggc      240

agtacctttt accccgacag cgtgaagggc aggttcaccg tcagcaggga caacagcaag      300

aacaccctgt acctgcagat gaactcactg agggcagagg acaccgccgt gtactactgc      360

gccagggacc ccaggcatga cgggtacttc ttcgactact ggggccaggg caccctggtg      420

acagttagct ctgctagcac caagggcccc agcgtgtttc ctctcgctcc ctgcagccgg      480

agcacatccg agagcaccgc tgctctgggc tgtctcgtga aggactactt ccctgaaccc      540

gtcaccgtca gctggaatag cggcgccctg acatccggcg tccacacatt ccccgctgtc      600

ctgcagagca gcggcctgta cagcctgagc tccgtggtca ccgtgcctag cagcagcctg      660

ggaacaaaga cctacacctg caacgtggac cataagccct ccaacaccaa ggtggacaag      720

cgggtggaat ccaagtatgg acccccctgt cctccttgcc ctgctcctga atttctcgga      780

ggcccctccg tcttcctgtt tccccccaag cccaaggaca ccctgatgat ctcccggaca      840

cccgaagtca cctgcgtcgt ggtggatgtc agccaggaag atcccgaggt gcagttcaac      900

tggtacgtgg acggagtgga ggtgcataac gccaaaacca agcccaggga agagcagttc      960

aacagcacct atcgggtcgt gtccgtgctc accgtcctgc atcaggattg gctcaacggc     1020

aaggagtaca agtgcaaggt gtccaacaag ggcctgccct cctccatcga gaagaccatc     1080

tccaaggcta agggccaacc tcgggagccc caagtgtata ccctccctcc cagccaggag     1140

gagatgacca agaatcaagt gagcctgacc tgcctcgtga agggatttta cccctccgac     1200

atcgctgtgg aatgggaaag caatggccaa cctgagaaca actacaagac cacacccccc     1260

gtgctggact ccgatggctc cttcttcctg tacagcaggc tgaccgtgga caaatcccgg     1320

tggcaagagg gaaacgtgtt cagctgctcc gtgatgcacg aggctctcca caaccactac     1380

acccagaaga gcctctccct gagcctcggc tagtaa                               1416


<210>  17
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain 6667; PP10766 H; PP10767 H; PP10768 H

<400>  17

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Thr Tyr Gly Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Leu Val Ala Ile Ile Asn His Asn Gly Gly 
65                  70                  75                  80  


Ser Thr Phe Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Arg His Asp Gly 
        115                 120                 125             


Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Leu Gly 
465                 470 


<210>  18
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH6667; PP10766 VH; PP10767 VH; PP10768 VH

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Ile Ile Asn His Asn Gly Gly Ser Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg His Asp Gly Tyr Phe Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  19
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain 6667 nucleotide; PP10766 H nucleotide; PP10767 H 
       nucleotide; PP10768 H nucleotide

<400>  19
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca actggtggag tccggcggag gtgtggtgca gcccggtcgc      120

agcctgaggc tgtcatgcgc agccagcggc ttcaccttca gcacctacgg catgagctgg      180

gtgaggcagg cacccggcaa gggcctggag ctggtggcaa tcatcaacca caacggcggc      240

agtacctttt accccgacag cgtgaagggc aggttcacca tcagcaggga caacagcaag      300

aacaccctgt acctgcagat gaactcactg agggcagagg acaccgccgt gtactactgc      360

gccagggacc ccaggcatga cgggtacttc ttcgactact ggggccaggg caccctggtg      420

acagttagct ctgctagcac caagggcccc agcgtgtttc ctctcgctcc ctgcagccgg      480

agcacatccg agagcaccgc tgctctgggc tgtctcgtga aggactactt ccctgaaccc      540

gtcaccgtca gctggaatag cggcgccctg acatccggcg tccacacatt ccccgctgtc      600

ctgcagagca gcggcctgta cagcctgagc tccgtggtca ccgtgcctag cagcagcctg      660

ggaacaaaga cctacacctg caacgtggac cataagccct ccaacaccaa ggtggacaag      720

cgggtggaat ccaagtatgg acccccctgt cctccttgcc ctgctcctga atttctcgga      780

ggcccctccg tcttcctgtt tccccccaag cccaaggaca ccctgatgat ctcccggaca      840

cccgaagtca cctgcgtcgt ggtggatgtc agccaggaag atcccgaggt gcagttcaac      900

tggtacgtgg acggagtgga ggtgcataac gccaaaacca agcccaggga agagcagttc      960

aacagcacct atcgggtcgt gtccgtgctc accgtcctgc atcaggattg gctcaacggc     1020

aaggagtaca agtgcaaggt gtccaacaag ggcctgccct cctccatcga gaagaccatc     1080

tccaaggcta agggccaacc tcgggagccc caagtgtata ccctccctcc cagccaggag     1140

gagatgacca agaatcaagt gagcctgacc tgcctcgtga agggatttta cccctccgac     1200

atcgctgtgg aatgggaaag caatggccaa cctgagaaca actacaagac cacacccccc     1260

gtgctggact ccgatggctc cttcttcctg tacagcaggc tgaccgtgga caaatcccgg     1320

tggcaagagg gaaacgtgtt cagctgctcc gtgatgcacg aggctctcca caaccactac     1380

acccagaaga gcctctccct gagcctcggc tagtaa                               1416


<210>  20
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain 6665; PP10760 L; PP10763 L; PP10766 L

<400>  20

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp 
        35                  40                  45              


Ile Tyr Asp Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp 
            100                 105                 110         


Ser Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  21
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL6665; PP10760 VL; PP10763 VL; PP10766 VL

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Asp Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  22
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain 6665 nucleotide; PP10760 L nucleotide; PP10763 L 
       nucleotide; PP10766 L nucleotide

<400>  22
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgcc aggcctccga ggacatctac gacaggctgg cctggtatca gcagaagccc      180

ggcaaggccc ccaaacttct gatctcaggg gccaccagct tggagaccgg cgtgcctagc      240

aggttcagcg gcagcggtag tggcaccgac tacaccttca ccatcagctc cctgcagccc      300

gaggatatcg ccacctacta ctgccagcag tattggagcg tgccatggac cttcggtggc      360

ggaactaagg tggagatcaa gcggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  23
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain 6666; PP10761 L; PP10764 L; PP10767 L

<400>  23

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp 
        35                  40                  45              


Ile Tyr Asp Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Tyr Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp 
            100                 105                 110         


Ser Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  24
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL6666; PP10761 VL; PP10764 VL; PP10767 VL

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Asp Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  25
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain 6666 nucleotide; PP10761 L nucleotide; PP10764 L 
       nucleotide; PP10767 L nucleotide

<400>  25
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgcc aggcctccga ggacatctac gacaggctgg cctggtatca gcagaagccc      180

ggcaaggccc ccaaacttct gatctcaggg gccaccagct tggagaccgg cgtgcctagc      240

aggttcagcg gcagcggtag tggcaaggac tacaccttca ccatcagctc cctgcagccc      300

gaggatatcg ccacctacta ctgccagcag tattggagcg tgccatggac cttcggtggc      360

ggaactaagg tggagatcaa gcggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  26
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain 6667; PP10762 L; PP10765 L; PP10768 L

<400>  26

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp 
        35                  40                  45              


Ile Tyr Asp Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Val Ser Gly Ala Thr Ser Leu Glu Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp 
            100                 105                 110         


Ser Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL6667; PP10762 VL; PP10765 VL; PP10768 VL

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asp Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Val 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  28
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain 6667 nucleotide; PP10762 L nucleotide; PP10765 L 
       nucleotide; PP10768 L nucleotide

<400>  28
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgca gggcctccga ggacatctac gacaggctgg cctggtatca gcagaagccc      180

ggcaaggccc ccaatcttct ggtctcaggg gccaccagct tggagagcgg cgtgcctagc      240

aggttcagcg gcagcggtag tggcaaggac tacaccctca ccatcagctc cctgcagccc      300

gaggatttcg ccacctacta ctgccagcag tattggagcg tgccatggac cttcggtggc      360

ggaactaagg tggagatcaa gcggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


