                         б

<110>  Ž
 
<120>  弰;

<130>  0069-PA-008

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  193
<212>  PRT
<213>  Mus musculus

<400>  1

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala 
    


<210>  2
<211>  313
<212>  PRT
<213>  Mus musculus

<400>  2

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser 
305                 310             


<210>  3
<211>  149
<212>  PRT
<213>  Mus musculus

<400>  3

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
        35                  40                  45              


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    50                  55                  60                  


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
65                  70                  75                  80  


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln 
145                 


<210>  4
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  4

Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu Ile 
1               5                   10                  15      


Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu Thr Val Arg 
    50                  55                  60                  


Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn Val 
65                  70                  75                  80  


Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Thr Phe 
                85                  90                  95      


Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  5
<211>  129
<212>  PRT
<213>  Mus musculus

<400>  5

Glu Cys His Ile Lys Asp Lys Glu Gly Lys Ala Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Ile Ser Ile Asp Glu Leu Asp Lys Met Thr Gly Thr Asp Ser Asn 
            20                  25                  30          


Cys Pro Asn Asn Glu Pro Asn Phe Phe Arg Lys His Val Cys Asp Asp 
        35                  40                  45              


Thr Lys Glu Ala Ala Phe Leu Asn Arg Ala Ala Arg Lys Leu Lys Gln 
    50                  55                  60                  


Phe Leu Lys Met Asn Ile Ser Glu Glu Phe Asn Val His Leu Leu Thr 
65                  70                  75                  80  


Val Ser Gln Gly Thr Gln Thr Leu Val Asn Cys Thr Ser Lys Glu Glu 
                85                  90                  95      


Lys Asn Val Lys Glu Gln Lys Lys Asn Asp Ala Cys Phe Leu Lys Arg 
            100                 105                 110         


Leu Leu Arg Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Lys Gly Ser 
        115                 120                 125             


Ile 
    


<210>  6
<211>  129
<212>  PRT
<213>  Mus musculus

<400>  6

His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu Arg 
1               5                   10                  15      


His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp Leu 
            20                  25                  30          


Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys Glu 
        35                  40                  45              


His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser Asn 
    50                  55                  60                  


Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu Arg 
65                  70                  75                  80  


Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile Ala 
                85                  90                  95      


Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His Leu 
        115                 120                 125             


Ser 
    


<210>  7
<211>  206
<212>  PRT
<213>  Mus musculus

<400>  7

Gly Thr Pro Asp Cys Tyr Phe Ser His Ser Pro Ile Ser Ser Asn Phe 
1               5                   10                  15      


Lys Val Lys Phe Arg Glu Leu Thr Asp His Leu Leu Lys Asp Tyr Pro 
            20                  25                  30          


Val Thr Val Ala Val Asn Leu Gln Asp Glu Lys His Cys Lys Ala Leu 
        35                  40                  45              


Trp Ser Leu Phe Leu Ala Gln Arg Trp Ile Glu Gln Leu Lys Thr Val 
    50                  55                  60                  


Ala Gly Ser Lys Met Gln Thr Leu Leu Glu Asp Val Asn Thr Glu Ile 
65                  70                  75                  80  


His Phe Val Thr Ser Cys Thr Phe Gln Pro Leu Pro Glu Cys Leu Arg 
                85                  90                  95      


Phe Val Gln Thr Asn Ile Ser His Leu Leu Lys Asp Thr Cys Thr Gln 
            100                 105                 110         


Leu Leu Ala Leu Lys Pro Cys Ile Gly Lys Ala Cys Gln Asn Phe Ser 
        115                 120                 125             


Arg Cys Leu Glu Val Gln Cys Gln Pro Asp Ser Ser Thr Leu Leu Pro 
    130                 135                 140                 


Pro Arg Ser Pro Ile Ala Leu Glu Ala Thr Glu Leu Pro Glu Pro Arg 
145                 150                 155                 160 


Pro Arg Gln Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Leu Thr Leu 
                165                 170                 175     


Val Leu Leu Ala Ala Ala Trp Gly Leu Arg Trp Gln Arg Ala Arg Arg 
            180                 185                 190         


Arg Gly Glu Leu His Pro Gly Val Pro Leu Pro Ser His Pro 
        195                 200                 205     


<210>  8
<211>  124
<212>  PRT
<213>  Mus musculus

<400>  8

Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val 
1               5                   10                  15      


Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr 
            20                  25                  30          


Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys 
        35                  40                  45              


Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg 
    50                  55                  60                  


Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr 
65                  70                  75                  80  


Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln 
                85                  90                  95      


Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr 
            100                 105                 110         


Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys 
        115                 120                 


<210>  9
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  9

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210>  10
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  10

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  11
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  12
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  12

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  13
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His 
145                 150         


<210>  14
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser 
    130             


<210>  15
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  15

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu 
145                 150                 155                 160 


Leu Leu Leu Leu Leu Leu Pro Val Gly Leu Leu Leu Leu Ala Ala Ala 
                165                 170                 175     


Trp Cys Leu His Trp Gln Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly 
            180                 185                 190         


Glu Gln Val Pro Pro Val Pro Ser Pro Gln Asp Leu Leu Leu Val Glu 
        195                 200                 205             


His 
    


<210>  16
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  17
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  

<400>  17

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  18
<211>  809
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL2IL12bGMCSF

<400>  18

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
    210                 215                 220                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
225                 230                 235                 240 


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
                245                 250                 255     


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
            260                 265                 270         


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
        275                 280                 285             


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
    290                 295                 300                 


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
305                 310                 315                 320 


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
                325                 330                 335     


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
            340                 345                 350         


Ser Thr Ser Pro Gln Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val 
        355                 360                 365             


Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr 
    370                 375                 380                 


Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg 
385                 390                 395                 400 


His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu 
                405                 410                 415     


Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu 
            420                 425                 430         


Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser 
        435                 440                 445             


Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu 
    450                 455                 460                 


Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg 
465                 470                 475                 480 


Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp 
                485                 490                 495     


Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val 
            500                 505                 510         


Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu 
        515                 520                 525             


Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala 
    530                 535                 540                 


Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe 
545                 550                 555                 560 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met 
                565                 570                 575     


Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
            580                 585                 590         


Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg 
        595                 600                 605             


Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn 
    610                 615                 620                 


Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys 
625                 630                 635                 640 


Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser 
                645                 650                 655     


Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
        675                 680                 685             


Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val Glu Ala Ile 
    690                 695                 700                 


Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu 
705                 710                 715                 720 


Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys 
                725                 730                 735     


Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe 
            740                 745                 750         


Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr 
        755                 760                 765             


Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr 
    770                 775                 780                 


Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro 
785                 790                 795                 800 


Phe Glu Cys Lys Lys Pro Gly Gln Lys 
                805                 


<210>  19
<211>  809
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL2IL12aIL12bGMCSF

<400>  19

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
        35                  40                  45              


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    50                  55                  60                  


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
65                  70                  75                  80  


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu 
                165                 170                 175     


Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr 
            180                 185                 190         


Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp 
        195                 200                 205             


His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu 
    210                 215                 220                 


Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr 
225                 230                 235                 240 


Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu 
                245                 250                 255     


Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            260                 265                 270         


Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His 
        275                 280                 285             


Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu 
    290                 295                 300                 


Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro 
305                 310                 315                 320 


Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu 
                325                 330                 335     


Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly 
            340                 345                 350         


Tyr Leu Ser Ser Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val 
        355                 360                 365             


Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr 
    370                 375                 380                 


Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg 
385                 390                 395                 400 


His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu 
                405                 410                 415     


Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu 
            420                 425                 430         


Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser 
        435                 440                 445             


Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu 
    450                 455                 460                 


Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg 
465                 470                 475                 480 


Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp 
                485                 490                 495     


Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val 
            500                 505                 510         


Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu 
        515                 520                 525             


Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala 
    530                 535                 540                 


Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe 
545                 550                 555                 560 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met 
                565                 570                 575     


Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
            580                 585                 590         


Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg 
        595                 600                 605             


Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn 
    610                 615                 620                 


Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys 
625                 630                 635                 640 


Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser 
                645                 650                 655     


Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
        675                 680                 685             


Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val Glu Ala Ile 
    690                 695                 700                 


Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu 
705                 710                 715                 720 


Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys 
                725                 730                 735     


Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe 
            740                 745                 750         


Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr 
        755                 760                 765             


Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr 
    770                 775                 780                 


Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro 
785                 790                 795                 800 


Phe Glu Cys Lys Lys Pro Gly Gln Lys 
                805                 


<210>  20
<211>  809
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL2GMCSFIL12b

<400>  20

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
    210                 215                 220                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
225                 230                 235                 240 


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
                245                 250                 255     


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
            260                 265                 270         


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
        275                 280                 285             


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
    290                 295                 300                 


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
305                 310                 315                 320 


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
                325                 330                 335     


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
            340                 345                 350         


Ser Thr Ser Pro Gln Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg 
        355                 360                 365             


Pro Trp Lys His Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp 
    370                 375                 380                 


Asp Met Pro Val Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu 
385                 390                 395                 400 


Phe Ser Phe Lys Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe 
                405                 410                 415     


Glu Gln Gly Leu Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn 
            420                 425                 430         


Met Thr Ala Ser Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr 
        435                 440                 445             


Asp Cys Glu Thr Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu 
    450                 455                 460                 


Lys Thr Phe Leu Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln 
465                 470                 475                 480 


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
            500                 505                 510         


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
        515                 520                 525             


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
    530                 535                 540                 


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
545                 550                 555                 560 


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
                565                 570                 575     


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
            580                 585                 590         


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
        595                 600                 605             


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
    610                 615                 620                 


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
625                 630                 635                 640 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
                645                 650                 655     


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
            660                 665                 670         


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
        675                 680                 685             


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
    690                 695                 700                 


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
705                 710                 715                 720 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
                725                 730                 735     


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
            740                 745                 750         


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
        755                 760                 765             


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
    770                 775                 780                 


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
785                 790                 795                 800 


Ala Cys Val Pro Cys Arg Val Arg Ser 
                805                 


<210>  21
<211>  809
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL2IL12aGMCSFIL12b

<400>  21

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
        35                  40                  45              


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    50                  55                  60                  


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
65                  70                  75                  80  


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu 
                165                 170                 175     


Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr 
            180                 185                 190         


Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp 
        195                 200                 205             


His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu 
    210                 215                 220                 


Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr 
225                 230                 235                 240 


Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu 
                245                 250                 255     


Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            260                 265                 270         


Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His 
        275                 280                 285             


Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu 
    290                 295                 300                 


Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro 
305                 310                 315                 320 


Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu 
                325                 330                 335     


Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly 
            340                 345                 350         


Tyr Leu Ser Ser Ala Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg 
        355                 360                 365             


Pro Trp Lys His Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp 
    370                 375                 380                 


Asp Met Pro Val Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu 
385                 390                 395                 400 


Phe Ser Phe Lys Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe 
                405                 410                 415     


Glu Gln Gly Leu Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn 
            420                 425                 430         


Met Thr Ala Ser Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr 
        435                 440                 445             


Asp Cys Glu Thr Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu 
    450                 455                 460                 


Lys Thr Phe Leu Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln 
465                 470                 475                 480 


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
            500                 505                 510         


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
        515                 520                 525             


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
    530                 535                 540                 


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
545                 550                 555                 560 


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
                565                 570                 575     


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
            580                 585                 590         


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
        595                 600                 605             


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
    610                 615                 620                 


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
625                 630                 635                 640 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
                645                 650                 655     


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
            660                 665                 670         


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
        675                 680                 685             


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
    690                 695                 700                 


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
705                 710                 715                 720 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
                725                 730                 735     


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
            740                 745                 750         


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
        755                 760                 765             


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
    770                 775                 780                 


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
785                 790                 795                 800 


Ala Cys Val Pro Cys Arg Val Arg Ser 
                805                 


<210>  22
<211>  809
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aGMCSFIL12bIL2

<400>  22

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val 
    210                 215                 220                 


Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr 
225                 230                 235                 240 


Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys 
                245                 250                 255     


Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg 
            260                 265                 270         


Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr 
        275                 280                 285             


Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln 
    290                 295                 300                 


Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr 
305                 310                 315                 320 


Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys Met Trp Glu Leu 
                325                 330                 335     


Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr Pro Asp Ala Pro 
            340                 345                 350         


Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile 
        355                 360                 365             


Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly Ser Gly Lys Thr 
    370                 375                 380                 


Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys 
385                 390                 395                 400 


His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu Leu Leu His Lys 
                405                 410                 415     


Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn 
            420                 425                 430         


Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr 
        435                 440                 445             


Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys Phe Asn Ile Lys 
    450                 455                 460                 


Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr Cys Gly Met Ala 
465                 470                 475                 480 


Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys 
                485                 490                 495     


Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro Thr Ala Glu Glu 
            500                 505                 510         


Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr 
        515                 520                 525             


Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp 
    530                 535                 540                 


Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn Ser Gln Val Glu 
545                 550                 555                 560 


Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro His Ser Tyr Phe 
                565                 570                 575     


Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys Glu Lys Met Lys 
            580                 585                 590         


Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe Leu Val Glu Lys 
        595                 600                 605             


Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val Cys Val Gln Ala 
    610                 615                 620                 


Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp Ala Cys Val Pro 
625                 630                 635                 640 


Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            660                 665                 670         


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        675                 680                 685             


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    690                 695                 700                 


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
705                 710                 715                 720 


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                725                 730                 735     


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            740                 745                 750         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        755                 760                 765             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    770                 775                 780                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
785                 790                 795                 800 


Gln Ser Ile Ile Ser Thr Ser Pro Gln 
                805                 


<210>  23
<211>  789
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL7IL12bGMCSF

<400>  23

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Glu Cys His Ile Lys Asp Lys Glu Gly Lys Ala Tyr Glu Ser Val Leu 
    210                 215                 220                 


Met Ile Ser Ile Asp Glu Leu Asp Lys Met Thr Gly Thr Asp Ser Asn 
225                 230                 235                 240 


Cys Pro Asn Asn Glu Pro Asn Phe Phe Arg Lys His Val Cys Asp Asp 
                245                 250                 255     


Thr Lys Glu Ala Ala Phe Leu Asn Arg Ala Ala Arg Lys Leu Lys Gln 
            260                 265                 270         


Phe Leu Lys Met Asn Ile Ser Glu Glu Phe Asn Val His Leu Leu Thr 
        275                 280                 285             


Val Ser Gln Gly Thr Gln Thr Leu Val Asn Cys Thr Ser Lys Glu Glu 
    290                 295                 300                 


Lys Asn Val Lys Glu Gln Lys Lys Asn Asp Ala Cys Phe Leu Lys Arg 
305                 310                 315                 320 


Leu Leu Arg Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Lys Gly Ser 
                325                 330                 335     


Ile Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp 
            340                 345                 350         


Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro 
        355                 360                 365             


Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile 
    370                 375                 380                 


Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala 
385                 390                 395                 400 


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His 
                405                 410                 415     


Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu 
            420                 425                 430         


Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr 
        435                 440                 445             


Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu 
    450                 455                 460                 


Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val 
465                 470                 475                 480 


Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln 
                485                 490                 495     


Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys 
            500                 505                 510         


Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg 
        515                 520                 525             


Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp 
    530                 535                 540                 


Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys 
545                 550                 555                 560 


Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr 
                565                 570                 575     


Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys 
            580                 585                 590         


Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala 
        595                 600                 605             


Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn 
    610                 615                 620                 


Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys 
625                 630                 635                 640 


Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Arg Ser Pro Ile 
            660                 665                 670         


Thr Val Thr Arg Pro Trp Lys His Val Glu Ala Ile Lys Glu Ala Leu 
        675                 680                 685             


Asn Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu Glu Val Glu Val 
    690                 695                 700                 


Val Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys Val Gln Thr Arg 
705                 710                 715                 720 


Leu Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe Thr Lys Leu Lys 
                725                 730                 735     


Gly Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr Tyr Cys Pro Pro 
            740                 745                 750         


Thr Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr Tyr Ala Asp Phe 
        755                 760                 765             


Ile Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro Phe Glu Cys Lys 
    770                 775                 780                 


Lys Pro Gly Gln Lys 
785                 


<210>  24
<211>  793
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL15IL12bGMCSF

<400>  24

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Ile His Val Phe Ile Leu Gly Cys Val Ser Val Gly Leu Pro Lys 
    210                 215                 220                 


Thr Glu Ala Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu 
225                 230                 235                 240 


Ser Leu Ile Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser 
                245                 250                 255     


Asp Phe His Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu 
            260                 265                 270         


Glu Leu Gln Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu 
        275                 280                 285             


Thr Val Arg Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn 
    290                 295                 300                 


Lys Asn Val Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
305                 310                 315                 320 


Lys Thr Phe Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met 
                325                 330                 335     


Phe Ile Asn Thr Ser Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val 
            340                 345                 350         


Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr 
        355                 360                 365             


Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg 
    370                 375                 380                 


His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu 
385                 390                 395                 400 


Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu 
                405                 410                 415     


Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser 
            420                 425                 430         


Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu 
        435                 440                 445             


Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg 
    450                 455                 460                 


Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp 
465                 470                 475                 480 


Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val 
                485                 490                 495     


Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu 
            500                 505                 510         


Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala 
        515                 520                 525             


Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe 
    530                 535                 540                 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met 
545                 550                 555                 560 


Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                565                 570                 575     


Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg 
            580                 585                 590         


Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn 
        595                 600                 605             


Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys 
    610                 615                 620                 


Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser 
625                 630                 635                 640 


Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
            660                 665                 670         


Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val Glu Ala Ile 
        675                 680                 685             


Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu 
    690                 695                 700                 


Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys 
705                 710                 715                 720 


Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe 
                725                 730                 735     


Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr 
            740                 745                 750         


Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr 
        755                 760                 765             


Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro 
    770                 775                 780                 


Phe Glu Cys Lys Lys Pro Gly Gln Lys 
785                 790             


<210>  25
<211>  789
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL21IL12bGMCSF

<400>  25

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu Arg 
    210                 215                 220                 


His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp Leu 
225                 230                 235                 240 


Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys Glu 
                245                 250                 255     


His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser Asn 
            260                 265                 270         


Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu Arg 
        275                 280                 285             


Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile Ala 
    290                 295                 300                 


Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu Phe 
305                 310                 315                 320 


Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His Leu 
                325                 330                 335     


Ser Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp 
            340                 345                 350         


Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro 
        355                 360                 365             


Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile 
    370                 375                 380                 


Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala 
385                 390                 395                 400 


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His 
                405                 410                 415     


Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu 
            420                 425                 430         


Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr 
        435                 440                 445             


Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu 
    450                 455                 460                 


Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val 
465                 470                 475                 480 


Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln 
                485                 490                 495     


Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys 
            500                 505                 510         


Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg 
        515                 520                 525             


Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp 
    530                 535                 540                 


Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys 
545                 550                 555                 560 


Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr 
                565                 570                 575     


Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys 
            580                 585                 590         


Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala 
        595                 600                 605             


Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn 
    610                 615                 620                 


Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys 
625                 630                 635                 640 


Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Arg Ser Pro Ile 
            660                 665                 670         


Thr Val Thr Arg Pro Trp Lys His Val Glu Ala Ile Lys Glu Ala Leu 
        675                 680                 685             


Asn Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu Glu Val Glu Val 
    690                 695                 700                 


Val Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys Val Gln Thr Arg 
705                 710                 715                 720 


Leu Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe Thr Lys Leu Lys 
                725                 730                 735     


Gly Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr Tyr Cys Pro Pro 
            740                 745                 750         


Thr Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr Tyr Ala Asp Phe 
        755                 760                 765             


Ile Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro Phe Glu Cys Lys 
    770                 775                 780                 


Lys Pro Gly Gln Lys 
785                 


<210>  26
<211>  891
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL2IL12bFLT3L

<400>  26

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
    210                 215                 220                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
225                 230                 235                 240 


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
                245                 250                 255     


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
            260                 265                 270         


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
        275                 280                 285             


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
    290                 295                 300                 


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
305                 310                 315                 320 


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
                325                 330                 335     


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
            340                 345                 350         


Ser Thr Ser Pro Gln Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val 
        355                 360                 365             


Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr 
    370                 375                 380                 


Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg 
385                 390                 395                 400 


His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu 
                405                 410                 415     


Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu 
            420                 425                 430         


Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser 
        435                 440                 445             


Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu 
    450                 455                 460                 


Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg 
465                 470                 475                 480 


Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp 
                485                 490                 495     


Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val 
            500                 505                 510         


Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu 
        515                 520                 525             


Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala 
    530                 535                 540                 


Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe 
545                 550                 555                 560 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met 
                565                 570                 575     


Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
            580                 585                 590         


Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg 
        595                 600                 605             


Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn 
    610                 615                 620                 


Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys 
625                 630                 635                 640 


Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser 
                645                 650                 655     


Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Pro 
        675                 680                 685             


Asp Cys Tyr Phe Ser His Ser Pro Ile Ser Ser Asn Phe Lys Val Lys 
    690                 695                 700                 


Phe Arg Glu Leu Thr Asp His Leu Leu Lys Asp Tyr Pro Val Thr Val 
705                 710                 715                 720 


Ala Val Asn Leu Gln Asp Glu Lys His Cys Lys Ala Leu Trp Ser Leu 
                725                 730                 735     


Phe Leu Ala Gln Arg Trp Ile Glu Gln Leu Lys Thr Val Ala Gly Ser 
            740                 745                 750         


Lys Met Gln Thr Leu Leu Glu Asp Val Asn Thr Glu Ile His Phe Val 
        755                 760                 765             


Thr Ser Cys Thr Phe Gln Pro Leu Pro Glu Cys Leu Arg Phe Val Gln 
    770                 775                 780                 


Thr Asn Ile Ser His Leu Leu Lys Asp Thr Cys Thr Gln Leu Leu Ala 
785                 790                 795                 800 


Leu Lys Pro Cys Ile Gly Lys Ala Cys Gln Asn Phe Ser Arg Cys Leu 
                805                 810                 815     


Glu Val Gln Cys Gln Pro Asp Ser Ser Thr Leu Leu Pro Pro Arg Ser 
            820                 825                 830         


Pro Ile Ala Leu Glu Ala Thr Glu Leu Pro Glu Pro Arg Pro Arg Gln 
        835                 840                 845             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Leu Thr Leu Val Leu Leu 
    850                 855                 860                 


Ala Ala Ala Trp Gly Leu Arg Trp Gln Arg Ala Arg Arg Arg Gly Glu 
865                 870                 875                 880 


Leu His Pro Gly Val Pro Leu Pro Ser His Pro 
                885                 890     


<210>  27
<211>  871
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL7IL12bFLT3L

<400>  27

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Glu Cys His Ile Lys Asp Lys Glu Gly Lys Ala Tyr Glu Ser Val Leu 
    210                 215                 220                 


Met Ile Ser Ile Asp Glu Leu Asp Lys Met Thr Gly Thr Asp Ser Asn 
225                 230                 235                 240 


Cys Pro Asn Asn Glu Pro Asn Phe Phe Arg Lys His Val Cys Asp Asp 
                245                 250                 255     


Thr Lys Glu Ala Ala Phe Leu Asn Arg Ala Ala Arg Lys Leu Lys Gln 
            260                 265                 270         


Phe Leu Lys Met Asn Ile Ser Glu Glu Phe Asn Val His Leu Leu Thr 
        275                 280                 285             


Val Ser Gln Gly Thr Gln Thr Leu Val Asn Cys Thr Ser Lys Glu Glu 
    290                 295                 300                 


Lys Asn Val Lys Glu Gln Lys Lys Asn Asp Ala Cys Phe Leu Lys Arg 
305                 310                 315                 320 


Leu Leu Arg Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Lys Gly Ser 
                325                 330                 335     


Ile Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp 
            340                 345                 350         


Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro 
        355                 360                 365             


Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile 
    370                 375                 380                 


Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala 
385                 390                 395                 400 


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His 
                405                 410                 415     


Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu 
            420                 425                 430         


Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr 
        435                 440                 445             


Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu 
    450                 455                 460                 


Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val 
465                 470                 475                 480 


Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln 
                485                 490                 495     


Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys 
            500                 505                 510         


Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg 
        515                 520                 525             


Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp 
    530                 535                 540                 


Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys 
545                 550                 555                 560 


Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr 
                565                 570                 575     


Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys 
            580                 585                 590         


Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala 
        595                 600                 605             


Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn 
    610                 615                 620                 


Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys 
625                 630                 635                 640 


Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Pro Asp Cys Tyr Phe 
            660                 665                 670         


Ser His Ser Pro Ile Ser Ser Asn Phe Lys Val Lys Phe Arg Glu Leu 
        675                 680                 685             


Thr Asp His Leu Leu Lys Asp Tyr Pro Val Thr Val Ala Val Asn Leu 
    690                 695                 700                 


Gln Asp Glu Lys His Cys Lys Ala Leu Trp Ser Leu Phe Leu Ala Gln 
705                 710                 715                 720 


Arg Trp Ile Glu Gln Leu Lys Thr Val Ala Gly Ser Lys Met Gln Thr 
                725                 730                 735     


Leu Leu Glu Asp Val Asn Thr Glu Ile His Phe Val Thr Ser Cys Thr 
            740                 745                 750         


Phe Gln Pro Leu Pro Glu Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        755                 760                 765             


His Leu Leu Lys Asp Thr Cys Thr Gln Leu Leu Ala Leu Lys Pro Cys 
    770                 775                 780                 


Ile Gly Lys Ala Cys Gln Asn Phe Ser Arg Cys Leu Glu Val Gln Cys 
785                 790                 795                 800 


Gln Pro Asp Ser Ser Thr Leu Leu Pro Pro Arg Ser Pro Ile Ala Leu 
                805                 810                 815     


Glu Ala Thr Glu Leu Pro Glu Pro Arg Pro Arg Gln Leu Leu Leu Leu 
            820                 825                 830         


Leu Leu Leu Leu Leu Pro Leu Thr Leu Val Leu Leu Ala Ala Ala Trp 
        835                 840                 845             


Gly Leu Arg Trp Gln Arg Ala Arg Arg Arg Gly Glu Leu His Pro Gly 
    850                 855                 860                 


Val Pro Leu Pro Ser His Pro 
865                 870     


<210>  28
<211>  875
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL15IL12bFLT3L

<400>  28

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Ile His Val Phe Ile Leu Gly Cys Val Ser Val Gly Leu Pro Lys 
    210                 215                 220                 


Thr Glu Ala Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu 
225                 230                 235                 240 


Ser Leu Ile Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser 
                245                 250                 255     


Asp Phe His Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu 
            260                 265                 270         


Glu Leu Gln Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu 
        275                 280                 285             


Thr Val Arg Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn 
    290                 295                 300                 


Lys Asn Val Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
305                 310                 315                 320 


Lys Thr Phe Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met 
                325                 330                 335     


Phe Ile Asn Thr Ser Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val 
            340                 345                 350         


Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr 
        355                 360                 365             


Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg 
    370                 375                 380                 


His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu 
385                 390                 395                 400 


Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu 
                405                 410                 415     


Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser 
            420                 425                 430         


Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu 
        435                 440                 445             


Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg 
    450                 455                 460                 


Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp 
465                 470                 475                 480 


Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val 
                485                 490                 495     


Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu 
            500                 505                 510         


Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala 
        515                 520                 525             


Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe 
    530                 535                 540                 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met 
545                 550                 555                 560 


Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                565                 570                 575     


Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg 
            580                 585                 590         


Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn 
        595                 600                 605             


Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys 
    610                 615                 620                 


Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser 
625                 630                 635                 640 


Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Pro 
            660                 665                 670         


Asp Cys Tyr Phe Ser His Ser Pro Ile Ser Ser Asn Phe Lys Val Lys 
        675                 680                 685             


Phe Arg Glu Leu Thr Asp His Leu Leu Lys Asp Tyr Pro Val Thr Val 
    690                 695                 700                 


Ala Val Asn Leu Gln Asp Glu Lys His Cys Lys Ala Leu Trp Ser Leu 
705                 710                 715                 720 


Phe Leu Ala Gln Arg Trp Ile Glu Gln Leu Lys Thr Val Ala Gly Ser 
                725                 730                 735     


Lys Met Gln Thr Leu Leu Glu Asp Val Asn Thr Glu Ile His Phe Val 
            740                 745                 750         


Thr Ser Cys Thr Phe Gln Pro Leu Pro Glu Cys Leu Arg Phe Val Gln 
        755                 760                 765             


Thr Asn Ile Ser His Leu Leu Lys Asp Thr Cys Thr Gln Leu Leu Ala 
    770                 775                 780                 


Leu Lys Pro Cys Ile Gly Lys Ala Cys Gln Asn Phe Ser Arg Cys Leu 
785                 790                 795                 800 


Glu Val Gln Cys Gln Pro Asp Ser Ser Thr Leu Leu Pro Pro Arg Ser 
                805                 810                 815     


Pro Ile Ala Leu Glu Ala Thr Glu Leu Pro Glu Pro Arg Pro Arg Gln 
            820                 825                 830         


Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Leu Thr Leu Val Leu Leu 
        835                 840                 845             


Ala Ala Ala Trp Gly Leu Arg Trp Gln Arg Ala Arg Arg Arg Gly Glu 
    850                 855                 860                 


Leu His Pro Gly Val Pro Leu Pro Ser His Pro 
865                 870                 875 


<210>  29
<211>  871
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL21IL12bFLT3L

<400>  29

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu Arg 
    210                 215                 220                 


His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp Leu 
225                 230                 235                 240 


Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys Glu 
                245                 250                 255     


His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser Asn 
            260                 265                 270         


Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu Arg 
        275                 280                 285             


Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile Ala 
    290                 295                 300                 


Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu Phe 
305                 310                 315                 320 


Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His Leu 
                325                 330                 335     


Ser Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp 
            340                 345                 350         


Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro 
        355                 360                 365             


Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile 
    370                 375                 380                 


Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala 
385                 390                 395                 400 


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His 
                405                 410                 415     


Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu 
            420                 425                 430         


Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr 
        435                 440                 445             


Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu 
    450                 455                 460                 


Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val 
465                 470                 475                 480 


Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln 
                485                 490                 495     


Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys 
            500                 505                 510         


Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg 
        515                 520                 525             


Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp 
    530                 535                 540                 


Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys 
545                 550                 555                 560 


Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr 
                565                 570                 575     


Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys 
            580                 585                 590         


Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala 
        595                 600                 605             


Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn 
    610                 615                 620                 


Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys 
625                 630                 635                 640 


Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Pro Asp Cys Tyr Phe 
            660                 665                 670         


Ser His Ser Pro Ile Ser Ser Asn Phe Lys Val Lys Phe Arg Glu Leu 
        675                 680                 685             


Thr Asp His Leu Leu Lys Asp Tyr Pro Val Thr Val Ala Val Asn Leu 
    690                 695                 700                 


Gln Asp Glu Lys His Cys Lys Ala Leu Trp Ser Leu Phe Leu Ala Gln 
705                 710                 715                 720 


Arg Trp Ile Glu Gln Leu Lys Thr Val Ala Gly Ser Lys Met Gln Thr 
                725                 730                 735     


Leu Leu Glu Asp Val Asn Thr Glu Ile His Phe Val Thr Ser Cys Thr 
            740                 745                 750         


Phe Gln Pro Leu Pro Glu Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        755                 760                 765             


His Leu Leu Lys Asp Thr Cys Thr Gln Leu Leu Ala Leu Lys Pro Cys 
    770                 775                 780                 


Ile Gly Lys Ala Cys Gln Asn Phe Ser Arg Cys Leu Glu Val Gln Cys 
785                 790                 795                 800 


Gln Pro Asp Ser Ser Thr Leu Leu Pro Pro Arg Ser Pro Ile Ala Leu 
                805                 810                 815     


Glu Ala Thr Glu Leu Pro Glu Pro Arg Pro Arg Gln Leu Leu Leu Leu 
            820                 825                 830         


Leu Leu Leu Leu Leu Pro Leu Thr Leu Val Leu Leu Ala Ala Ala Trp 
        835                 840                 845             


Gly Leu Arg Trp Gln Arg Ala Arg Arg Arg Gly Glu Leu His Pro Gly 
    850                 855                 860                 


Val Pro Leu Pro Ser His Pro 
865                 870     


<210>  30
<211>  793
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL2IL12bGMCSF

<400>  30

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
    210                 215                 220                 


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
225                 230                 235                 240 


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
                245                 250                 255     


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
            260                 265                 270         


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
        275                 280                 285             


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
    290                 295                 300                 


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
305                 310                 315                 320 


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
                325                 330                 335     


Cys Gln Ser Ile Ile Ser Thr Leu Thr Ile Trp Glu Leu Lys Lys Asp 
            340                 345                 350         


Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met 
        355                 360                 365             


Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr 
    370                 375                 380                 


Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile 
385                 390                 395                 400 


Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly 
                405                 410                 415     


Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp 
            420                 425                 430         


Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn 
        435                 440                 445             


Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr 
    450                 455                 460                 


Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys 
465                 470                 475                 480 


Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala 
                485                 490                 495     


Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr 
            500                 505                 510         


Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser 
        515                 520                 525             


Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu 
    530                 535                 540                 


Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro 
545                 550                 555                 560 


Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu 
                565                 570                 575     


Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe 
            580                 585                 590         


Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys 
        595                 600                 605             


Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg 
    610                 615                 620                 


Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser 
625                 630                 635                 640 


Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Arg Ser Pro 
            660                 665                 670         


Ser Pro Ser Thr Gln Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala 
        675                 680                 685             


Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu 
    690                 695                 700                 


Thr Val Glu Val Ile Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys 
705                 710                 715                 720 


Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu 
                725                 730                 735     


Thr Lys Leu Lys Gly Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln 
            740                 745                 750         


His Cys Pro Pro Thr Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr 
        755                 760                 765             


Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro 
    770                 775                 780                 


Phe Asp Cys Trp Glu Pro Val Gln Glu 
785                 790             


<210>  31
<211>  812
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL7IL12bGMCSF

<400>  31

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr 
    210                 215                 220                 


Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys 
225                 230                 235                 240 


Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg 
                245                 250                 255     


His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala 
            260                 265                 270         


Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp 
        275                 280                 285             


Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys 
    290                 295                 300                 


Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln 
305                 310                 315                 320 


Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys 
                325                 330                 335     


Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr 
            340                 345                 350         


Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Ile Trp Glu Leu 
        355                 360                 365             


Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro 
    370                 375                 380                 


Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile 
385                 390                 395                 400 


Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr 
                405                 410                 415     


Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys 
            420                 425                 430         


His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys 
        435                 440                 445             


Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu 
    450                 455                 460                 


Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly 
465                 470                 475                 480 


Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe 
                485                 490                 495     


Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys 
            500                 505                 510         


Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu 
        515                 520                 525             


Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala 
    530                 535                 540                 


Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu 
545                 550                 555                 560 


Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys 
                565                 570                 575     


Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg 
            580                 585                 590         


Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His 
        595                 600                 605             


Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys 
    610                 615                 620                 


Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val 
625                 630                 635                 640 


Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr 
                645                 650                 655     


Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala 
        675                 680                 685             


Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val Asn Ala Ile 
    690                 695                 700                 


Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr Ala Ala Glu 
705                 710                 715                 720 


Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp Leu Gln Glu 
                725                 730                 735     


Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln Gly Leu Arg 
            740                 745                 750         


Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met Ala Ser His 
        755                 760                 765             


Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys Ala Thr Gln 
    770                 775                 780                 


Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp Phe Leu Leu 
785                 790                 795                 800 


Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
                805                 810         


<210>  32
<211>  793
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL15IL12bGMCSF

<400>  32

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala 
    210                 215                 220                 


Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu 
225                 230                 235                 240 


Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
                245                 250                 255     


Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
            260                 265                 270         


Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
        275                 280                 285             


Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
    290                 295                 300                 


Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
305                 310                 315                 320 


Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
                325                 330                 335     


Ile Val Gln Met Phe Ile Asn Thr Ser Ile Trp Glu Leu Lys Lys Asp 
            340                 345                 350         


Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met 
        355                 360                 365             


Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr 
    370                 375                 380                 


Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile 
385                 390                 395                 400 


Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly 
                405                 410                 415     


Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp 
            420                 425                 430         


Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn 
        435                 440                 445             


Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr 
    450                 455                 460                 


Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys 
465                 470                 475                 480 


Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala 
                485                 490                 495     


Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr 
            500                 505                 510         


Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser 
        515                 520                 525             


Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu 
    530                 535                 540                 


Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro 
545                 550                 555                 560 


Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu 
                565                 570                 575     


Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe 
            580                 585                 590         


Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys 
        595                 600                 605             


Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg 
    610                 615                 620                 


Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser 
625                 630                 635                 640 


Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Arg Ser Pro 
            660                 665                 670         


Ser Pro Ser Thr Gln Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala 
        675                 680                 685             


Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu 
    690                 695                 700                 


Thr Val Glu Val Ile Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys 
705                 710                 715                 720 


Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu 
                725                 730                 735     


Thr Lys Leu Lys Gly Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln 
            740                 745                 750         


His Cys Pro Pro Thr Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr 
        755                 760                 765             


Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro 
    770                 775                 780                 


Phe Asp Cys Trp Glu Pro Val Gln Glu 
785                 790             


<210>  33
<211>  793
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL21IL12bGMCSF

<400>  33

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln 
    210                 215                 220                 


Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val 
225                 230                 235                 240 


Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp 
                245                 250                 255     


Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr 
            260                 265                 270         


Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg 
        275                 280                 285             


Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr 
    290                 295                 300                 


Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu 
305                 310                 315                 320 


Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser 
                325                 330                 335     


Ser Arg Thr His Gly Ser Glu Asp Ser Ile Trp Glu Leu Lys Lys Asp 
            340                 345                 350         


Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met 
        355                 360                 365             


Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr 
    370                 375                 380                 


Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile 
385                 390                 395                 400 


Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly 
                405                 410                 415     


Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp 
            420                 425                 430         


Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn 
        435                 440                 445             


Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr 
    450                 455                 460                 


Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys 
465                 470                 475                 480 


Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala 
                485                 490                 495     


Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr 
            500                 505                 510         


Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser 
        515                 520                 525             


Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu 
    530                 535                 540                 


Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro 
545                 550                 555                 560 


Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu 
                565                 570                 575     


Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe 
            580                 585                 590         


Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys 
        595                 600                 605             


Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg 
    610                 615                 620                 


Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser 
625                 630                 635                 640 


Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Arg Ser Pro 
            660                 665                 670         


Ser Pro Ser Thr Gln Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala 
        675                 680                 685             


Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu 
    690                 695                 700                 


Thr Val Glu Val Ile Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys 
705                 710                 715                 720 


Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu 
                725                 730                 735     


Thr Lys Leu Lys Gly Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln 
            740                 745                 750         


His Cys Pro Pro Thr Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr 
        755                 760                 765             


Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro 
    770                 775                 780                 


Phe Asp Cys Trp Glu Pro Val Gln Glu 
785                 790             


<210>  34
<211>  875
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL2IL12bFLT3L

<400>  34

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
    210                 215                 220                 


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
225                 230                 235                 240 


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
                245                 250                 255     


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
            260                 265                 270         


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
        275                 280                 285             


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
    290                 295                 300                 


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
305                 310                 315                 320 


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
                325                 330                 335     


Cys Gln Ser Ile Ile Ser Thr Leu Thr Ile Trp Glu Leu Lys Lys Asp 
            340                 345                 350         


Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met 
        355                 360                 365             


Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr 
    370                 375                 380                 


Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile 
385                 390                 395                 400 


Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly 
                405                 410                 415     


Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp 
            420                 425                 430         


Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn 
        435                 440                 445             


Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr 
    450                 455                 460                 


Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys 
465                 470                 475                 480 


Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala 
                485                 490                 495     


Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr 
            500                 505                 510         


Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser 
        515                 520                 525             


Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu 
    530                 535                 540                 


Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro 
545                 550                 555                 560 


Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu 
                565                 570                 575     


Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe 
            580                 585                 590         


Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys 
        595                 600                 605             


Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg 
    610                 615                 620                 


Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser 
625                 630                 635                 640 


Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe 
            660                 665                 670         


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        675                 680                 685             


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    690                 695                 700                 


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
705                 710                 715                 720 


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                725                 730                 735     


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            740                 745                 750         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        755                 760                 765             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    770                 775                 780                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
785                 790                 795                 800 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                805                 810                 815     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            820                 825                 830         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln 
        835                 840                 845             


Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val 
    850                 855                 860                 


Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
865                 870                 875 


<210>  35
<211>  894
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL7IL12bFLT3L

<400>  35

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr 
    210                 215                 220                 


Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys 
225                 230                 235                 240 


Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg 
                245                 250                 255     


His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala 
            260                 265                 270         


Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp 
        275                 280                 285             


Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys 
    290                 295                 300                 


Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln 
305                 310                 315                 320 


Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys 
                325                 330                 335     


Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr 
            340                 345                 350         


Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Ile Trp Glu Leu 
        355                 360                 365             


Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro 
    370                 375                 380                 


Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile 
385                 390                 395                 400 


Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr 
                405                 410                 415     


Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys 
            420                 425                 430         


His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys 
        435                 440                 445             


Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu 
    450                 455                 460                 


Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly 
465                 470                 475                 480 


Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe 
                485                 490                 495     


Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys 
            500                 505                 510         


Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu 
        515                 520                 525             


Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala 
    530                 535                 540                 


Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu 
545                 550                 555                 560 


Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys 
                565                 570                 575     


Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg 
            580                 585                 590         


Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His 
        595                 600                 605             


Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys 
    610                 615                 620                 


Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val 
625                 630                 635                 640 


Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr 
                645                 650                 655     


Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gln Asp 
        675                 680                 685             


Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 
    690                 695                 700                 


Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 
705                 710                 715                 720 


Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 
                725                 730                 735     


Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 
            740                 745                 750         


Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr 
        755                 760                 765             


Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr 
    770                 775                 780                 


Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu 
785                 790                 795                 800 


Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln 
                805                 810                 815     


Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro 
            820                 825                 830         


Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu 
        835                 840                 845             


Leu Leu Leu Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu 
    850                 855                 860                 


His Trp Gln Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val 
865                 870                 875                 880 


Pro Pro Val Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
                885                 890                 


<210>  36
<211>  875
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL15IL12bFLT3L

<400>  36

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala 
    210                 215                 220                 


Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu 
225                 230                 235                 240 


Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
                245                 250                 255     


Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
            260                 265                 270         


Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
        275                 280                 285             


Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
    290                 295                 300                 


Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
305                 310                 315                 320 


Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
                325                 330                 335     


Ile Val Gln Met Phe Ile Asn Thr Ser Ile Trp Glu Leu Lys Lys Asp 
            340                 345                 350         


Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met 
        355                 360                 365             


Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr 
    370                 375                 380                 


Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile 
385                 390                 395                 400 


Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly 
                405                 410                 415     


Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp 
            420                 425                 430         


Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn 
        435                 440                 445             


Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr 
    450                 455                 460                 


Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys 
465                 470                 475                 480 


Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala 
                485                 490                 495     


Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr 
            500                 505                 510         


Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser 
        515                 520                 525             


Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu 
    530                 535                 540                 


Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro 
545                 550                 555                 560 


Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu 
                565                 570                 575     


Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe 
            580                 585                 590         


Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys 
        595                 600                 605             


Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg 
    610                 615                 620                 


Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser 
625                 630                 635                 640 


Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe 
            660                 665                 670         


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        675                 680                 685             


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    690                 695                 700                 


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
705                 710                 715                 720 


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                725                 730                 735     


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            740                 745                 750         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        755                 760                 765             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    770                 775                 780                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
785                 790                 795                 800 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                805                 810                 815     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            820                 825                 830         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln 
        835                 840                 845             


Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val 
    850                 855                 860                 


Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
865                 870                 875 


<210>  37
<211>  875
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL21IL12bFLT3L

<400>  37

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln 
    210                 215                 220                 


Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val 
225                 230                 235                 240 


Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp 
                245                 250                 255     


Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr 
            260                 265                 270         


Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg 
        275                 280                 285             


Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr 
    290                 295                 300                 


Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu 
305                 310                 315                 320 


Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser 
                325                 330                 335     


Ser Arg Thr His Gly Ser Glu Asp Ser Ile Trp Glu Leu Lys Lys Asp 
            340                 345                 350         


Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met 
        355                 360                 365             


Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr 
    370                 375                 380                 


Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile 
385                 390                 395                 400 


Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly 
                405                 410                 415     


Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp 
            420                 425                 430         


Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn 
        435                 440                 445             


Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr 
    450                 455                 460                 


Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys 
465                 470                 475                 480 


Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala 
                485                 490                 495     


Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr 
            500                 505                 510         


Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser 
        515                 520                 525             


Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu 
    530                 535                 540                 


Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro 
545                 550                 555                 560 


Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu 
                565                 570                 575     


Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe 
            580                 585                 590         


Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys 
        595                 600                 605             


Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg 
    610                 615                 620                 


Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser 
625                 630                 635                 640 


Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe 
            660                 665                 670         


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        675                 680                 685             


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    690                 695                 700                 


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
705                 710                 715                 720 


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                725                 730                 735     


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            740                 745                 750         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        755                 760                 765             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    770                 775                 780                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
785                 790                 795                 800 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                805                 810                 815     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            820                 825                 830         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln 
        835                 840                 845             


Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val 
    850                 855                 860                 


Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
865                 870                 875 


<210>  38
<211>  2616
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL2IL12bGMCSFĺ

<400>  38
atgtgtcaat cacgctacct cctctttttg gccacccttg ccctcctaaa ccacctcagt       60

ttggccaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg      120

ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc      180

actgctgaag acatcgatca tgaagacatc acacgggacc aaaccagcac attgaagacc      240

tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc      300

acaacaagag ggagctgcct gcccccacag aagacgtctt tgatgatgac cctgtgcctt      360

ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca      420

cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgctggt ggccatcgat      480

gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga      540

gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc      600

cgcgtcgtga ccatcaacag ggtgatgggc tatctgagct ccgccggtgg aggaggttct      660

ggaggcggtg gaagtggtgg cggaggtagc gcacccactt caagctccac ttcaagctct      720

acagcggaag cacagcagca gcagcagcag cagcagcagc agcagcagca cctggagcag      780

ctgttgatgg acctacagga gctcctgagc aggatggaga attacaggaa cctgaaactc      840

cccaggatgc tcaccttcaa attttacttg cccaagcagg ccacagaatt gaaagatctt      900

cagtgcctag aagatgaact tggacctctg cggcatgttc tggatttgac tcaaagcaaa      960

agctttcaat tggaagatgc tgagaatttc atcagcaata tcagagtaac tgttgtaaaa     1020

ctaaagggct ctgacaacac atttgagtgc caattcgatg atgagtcagc aactgtggtg     1080

gactttctga ggagatggat agccttctgt caaagcatca tctcaacaag ccctcaagag     1140

ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc tatgtgtcct     1200

cagaagctaa ccatctcctg gtttgccatc gttttgctgg tgtctccact catggccatg     1260

tgggagctgg agaaagacgt ttatgttgta gaggtggact ggactcccga tgcccctgga     1320

gaaacagtga acctcacctg tgacacgcct gaagaagatg acatcacctg gacctcagac     1380

cagagacatg gagtcatagg ctctggaaag accctgacca tcactgtcaa agagtttcta     1440

gatgctggcc agtacacctg ccacaaagga ggcgagactc tgagccactc acatctgctg     1500

ctccacaaga aggaaaatgg aatttggtcc actgaaattt taaaaaattt caaaaacaag     1560

actttcctga agtgtgaagc accaaattac tccggacggt tcacgtgctc atggctggtg     1620

caaagaaaca tggacttgaa gttcaacatc aagagcagta gcagttcccc tgactctcgg     1680

gcagtgacat gtggaatggc gtctctgtct gcagagaagg tcacactgga ccaaagggac     1740

tatgagaagt attcagtgtc ctgccaggag gatgtcacct gcccaactgc cgaggagacc     1800

ctgcccattg aactggcgtt ggaagcacgg cagcagaata aatatgagaa ctacagcacc     1860

agcttcttca tcagggacat catcaaacca gacccgccca agaacttgca gatgaagcct     1920

ttgaagaact cacaggtgga ggtcagctgg gagtaccctg actcctggag cactccccat     1980

tcctacttct ccctcaagtt ctttgttcga atccagcgca agaaagaaaa gatgaaggag     2040

acagaggagg ggtgtaacca gaaaggtgcg ttcctcgtag agaagacatc taccgaagtc     2100

caatgcaaag gcgggaatgt ctgcgtgcaa gctcaggatc gctattacaa ttcctcgtgc     2160

agcaagtggg catgtgttcc ctgcagggtc cgatccggag gcggtggaag tggcggtgga     2220

ggctctggag gtggcggaag cgcacccacc cgctcaccca tcactgtcac ccggccttgg     2280

aagcatgtag aggccatcaa agaagccctg aacctcctgg atgacatgcc tgtcacgttg     2340

aatgaagagg tagaagtcgt ctctaacgag ttctccttca agaagctaac atgtgtgcag     2400

acccgcctga agatattcga gcagggtcta cggggcaatt tcaccaaact caagggcgcc     2460

ttgaacatga cagccagcta ctaccagaca tactgccccc caactccgga aacggactgt     2520

gaaacacaag ttaccaccta tgcggatttc atagacagcc ttaaaacctt tctgactgat     2580

atcccctttg aatgcaaaaa accaggccaa aaatga                               2616


<210>  39
<211>  2610
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL2IL12aIL12bGMCSFĺ

<400>  39
atgtacagca tgcagctcgc atcctgtgtc acattgacac ttgtgctcct tgtcaacagc       60

gcacccactt caagctccac ttcaagctct acagcggaag cacagcagca gcagcagcag      120

cagcagcagc agcagcagca cctggagcag ctgttgatgg acctacagga gctcctgagc      180

aggatggaga attacaggaa cctgaaactc cccaggatgc tcaccttcaa attttacttg      240

cccaagcagg ccacagaatt gaaagatctt cagtgcctag aagatgaact tggacctctg      300

cggcatgttc tggatttgac tcaaagcaaa agctttcaat tggaagatgc tgagaatttc      360

atcagcaata tcagagtaac tgttgtaaaa ctaaagggct ctgacaacac atttgagtgc      420

caattcgatg atgagtcagc aactgtggtg gactttctga ggagatggat agccttctgt      480

caaagcatca tctcaacaag ccctcaaggt ggaggaggtt ctggaggcgg tggaagtggt      540

ggcggaggta gcagggtcat tccagtctct ggacctgcca ggtgtcttag ccagtcccga      600

aacctgctga agaccacaga tgacatggtg aagacggcca gagaaaaact gaaacattat      660

tcctgcactg ctgaagacat cgatcatgaa gacatcacac gggaccaaac cagcacattg      720

aagacctgtt taccactgga actacacaag aacgagagtt gcctggctac tagagagact      780

tcttccacaa caagagggag ctgcctgccc ccacagaaga cgtctttgat gatgaccctg      840

tgccttggta gcatctatga ggacttgaag atgtaccaga cagagttcca ggccatcaac      900

gcagcacttc agaatcacaa ccatcagcag atcattctag acaagggcat gctggtggcc      960

atcgatgagc tgatgcagtc tctgaatcat aatggcgaga ctctgcgcca gaaacctcct     1020

gtgggagaag cagaccctta cagagtgaaa atgaagctct gcatcctgct tcacgccttc     1080

agcacccgcg tcgtgaccat caacagggtg atgggctatc tgagctccgc cgagggcaga     1140

ggaagtcttc taacatgcgg tgacgtggag gagaatcccg gccctatgtg tcctcagaag     1200

ctaaccatct cctggtttgc catcgttttg ctggtgtctc cactcatggc catgtgggag     1260

ctggagaaag acgtttatgt tgtagaggtg gactggactc ccgatgcccc tggagaaaca     1320

gtgaacctca cctgtgacac gcctgaagaa gatgacatca cctggacctc agaccagaga     1380

catggagtca taggctctgg aaagaccctg accatcactg tcaaagagtt tctagatgct     1440

ggccagtaca cctgccacaa aggaggcgag actctgagcc actcacatct gctgctccac     1500

aagaaggaaa atggaatttg gtccactgaa attttaaaaa atttcaaaaa caagactttc     1560

ctgaagtgtg aagcaccaaa ttactccgga cggttcacgt gctcatggct ggtgcaaaga     1620

aacatggact tgaagttcaa catcaagagc agtagcagtt cccctgactc tcgggcagtg     1680

acatgtggaa tggcgtctct gtctgcagag aaggtcacac tggaccaaag ggactatgag     1740

aagtattcag tgtcctgcca ggaggatgtc acctgcccaa ctgccgagga gaccctgccc     1800

attgaactgg cgttggaagc acggcagcag aataaatatg agaactacag caccagcttc     1860

ttcatcaggg acatcatcaa accagacccg cccaagaact tgcagatgaa gcctttgaag     1920

aactcacagg tggaggtcag ctgggagtac cctgactcct ggagcactcc ccattcctac     1980

ttctccctca agttctttgt tcgaatccag cgcaagaaag aaaagatgaa ggagacagag     2040

gaggggtgta accagaaagg tgcgttcctc gtagagaaga catctaccga agtccaatgc     2100

aaaggcggga atgtctgcgt gcaagctcag gatcgctatt acaattcctc gtgcagcaag     2160

tgggcatgtg ttccctgcag ggtccgatcc ggaggcggtg gaagtggcgg tggaggctct     2220

ggaggtggcg gaagcgcacc cacccgctca cccatcactg tcacccggcc ttggaagcat     2280

gtagaggcca tcaaagaagc cctgaacctc ctggatgaca tgcctgtcac gttgaatgaa     2340

gaggtagaag tcgtctctaa cgagttctcc ttcaagaagc taacatgtgt gcagacccgc     2400

ctgaagatat tcgagcaggg tctacggggc aatttcacca aactcaaggg cgccttgaac     2460

atgacagcca gctactacca gacatactgc cccccaactc cggaaacgga ctgtgaaaca     2520

caagttacca cctatgcgga tttcatagac agccttaaaa cctttctgac tgatatcccc     2580

tttgaatgca aaaaaccagg ccaaaaatga                                      2610


<210>  40
<211>  2601
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL2GMCSFIL12bĺ

<400>  40
atgtgtcaat cacgctacct cctctttttg gccacccttg ccctcctaaa ccacctcagt       60

ttggccaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg      120

ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc      180

actgctgaag acatcgatca tgaagacatc acacgggacc aaaccagcac attgaagacc      240

tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc      300

acaacaagag ggagctgcct gcccccacag aagacgtctt tgatgatgac cctgtgcctt      360

ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca      420

cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgctggt ggccatcgat      480

gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga      540

gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc      600

cgcgtcgtga ccatcaacag ggtgatgggc tatctgagct ccgccggtgg aggaggttct      660

ggaggcggtg gaagtggtgg cggaggtagc gcacccactt caagctccac ttcaagctct      720

acagcggaag cacagcagca gcagcagcag cagcagcagc agcagcagca cctggagcag      780

ctgttgatgg acctacagga gctcctgagc aggatggaga attacaggaa cctgaaactc      840

cccaggatgc tcaccttcaa attttacttg cccaagcagg ccacagaatt gaaagatctt      900

cagtgcctag aagatgaact tggacctctg cggcatgttc tggatttgac tcaaagcaaa      960

agctttcaat tggaagatgc tgagaatttc atcagcaata tcagagtaac tgttgtaaaa     1020

ctaaagggct ctgacaacac atttgagtgc caattcgatg atgagtcagc aactgtggtg     1080

gactttctga ggagatggat agccttctgt caaagcatca tctcaacaag ccctcaagag     1140

ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc tatgtggctg     1200

cagaatttac ttttcctggg cattgtggtc tacagcctct cagcacccac ccgctcaccc     1260

atcactgtca cccggccttg gaagcatgta gaggccatca aagaagccct gaacctcctg     1320

gatgacatgc ctgtcacgtt gaatgaagag gtagaagtcg tctctaacga gttctccttc     1380

aagaagctaa catgtgtgca gacccgcctg aagatattcg agcagggtct acggggcaat     1440

ttcaccaaac tcaagggcgc cttgaacatg acagccagct actaccagac atactgcccc     1500

ccaactccgg aaacggactg tgaaacacaa gttaccacct atgcggattt catagacagc     1560

cttaaaacct ttctgactga tatccccttt gaatgcaaaa aaccaggcca aaaaggaggc     1620

ggtggaagtg gcggtggagg ctctggaggt ggcggaagca tgtgggagct ggagaaagac     1680

gtttatgttg tagaggtgga ctggactccc gatgcccctg gagaaacagt gaacctcacc     1740

tgtgacacgc ctgaagaaga tgacatcacc tggacctcag accagagaca tggagtcata     1800

ggctctggaa agaccctgac catcactgtc aaagagtttc tagatgctgg ccagtacacc     1860

tgccacaaag gaggcgagac tctgagccac tcacatctgc tgctccacaa gaaggaaaat     1920

ggaatttggt ccactgaaat tttaaaaaat ttcaaaaaca agactttcct gaagtgtgaa     1980

gcaccaaatt actccggacg gttcacgtgc tcatggctgg tgcaaagaaa catggacttg     2040

aagttcaaca tcaagagcag tagcagttcc cctgactctc gggcagtgac atgtggaatg     2100

gcgtctctgt ctgcagagaa ggtcacactg gaccaaaggg actatgagaa gtattcagtg     2160

tcctgccagg aggatgtcac ctgcccaact gccgaggaga ccctgcccat tgaactggcg     2220

ttggaagcac ggcagcagaa taaatatgag aactacagca ccagcttctt catcagggac     2280

atcatcaaac cagacccgcc caagaacttg cagatgaagc ctttgaagaa ctcacaggtg     2340

gaggtcagct gggagtaccc tgactcctgg agcactcccc attcctactt ctccctcaag     2400

ttctttgttc gaatccagcg caagaaagaa aagatgaagg agacagagga ggggtgtaac     2460

cagaaaggtg cgttcctcgt agagaagaca tctaccgaag tccaatgcaa aggcgggaat     2520

gtctgcgtgc aagctcagga tcgctattac aattcctcgt gcagcaagtg ggcatgtgtt     2580

ccctgcaggg tccgatccta g                                               2601


<210>  41
<211>  2595
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL2IL12aGMCSFIL12bĺ

<400>  41
atgtacagca tgcagctcgc atcctgtgtc acattgacac ttgtgctcct tgtcaacagc       60

gcacccactt caagctccac ttcaagctct acagcggaag cacagcagca gcagcagcag      120

cagcagcagc agcagcagca cctggagcag ctgttgatgg acctacagga gctcctgagc      180

aggatggaga attacaggaa cctgaaactc cccaggatgc tcaccttcaa attttacttg      240

cccaagcagg ccacagaatt gaaagatctt cagtgcctag aagatgaact tggacctctg      300

cggcatgttc tggatttgac tcaaagcaaa agctttcaat tggaagatgc tgagaatttc      360

atcagcaata tcagagtaac tgttgtaaaa ctaaagggct ctgacaacac atttgagtgc      420

caattcgatg atgagtcagc aactgtggtg gactttctga ggagatggat agccttctgt      480

caaagcatca tctcaacaag ccctcaaggt ggaggaggtt ctggaggcgg tggaagtggt      540

ggcggaggta gcagggtcat tccagtctct ggacctgcca ggtgtcttag ccagtcccga      600

aacctgctga agaccacaga tgacatggtg aagacggcca gagaaaaact gaaacattat      660

tcctgcactg ctgaagacat cgatcatgaa gacatcacac gggaccaaac cagcacattg      720

aagacctgtt taccactgga actacacaag aacgagagtt gcctggctac tagagagact      780

tcttccacaa caagagggag ctgcctgccc ccacagaaga cgtctttgat gatgaccctg      840

tgccttggta gcatctatga ggacttgaag atgtaccaga cagagttcca ggccatcaac      900

gcagcacttc agaatcacaa ccatcagcag atcattctag acaagggcat gctggtggcc      960

atcgatgagc tgatgcagtc tctgaatcat aatggcgaga ctctgcgcca gaaacctcct     1020

gtgggagaag cagaccctta cagagtgaaa atgaagctct gcatcctgct tcacgccttc     1080

agcacccgcg tcgtgaccat caacagggtg atgggctatc tgagctccgc cgagggcaga     1140

ggaagtcttc taacatgcgg tgacgtggag gagaatcccg gccctatgtg gctgcagaat     1200

ttacttttcc tgggcattgt ggtctacagc ctctcagcac ccacccgctc acccatcact     1260

gtcacccggc cttggaagca tgtagaggcc atcaaagaag ccctgaacct cctggatgac     1320

atgcctgtca cgttgaatga agaggtagaa gtcgtctcta acgagttctc cttcaagaag     1380

ctaacatgtg tgcagacccg cctgaagata ttcgagcagg gtctacgggg caatttcacc     1440

aaactcaagg gcgccttgaa catgacagcc agctactacc agacatactg ccccccaact     1500

ccggaaacgg actgtgaaac acaagttacc acctatgcgg atttcataga cagccttaaa     1560

acctttctga ctgatatccc ctttgaatgc aaaaaaccag gccaaaaagg aggcggtgga     1620

agtggcggtg gaggctctgg aggtggcgga agcatgtggg agctggagaa agacgtttat     1680

gttgtagagg tggactggac tcccgatgcc cctggagaaa cagtgaacct cacctgtgac     1740

acgcctgaag aagatgacat cacctggacc tcagaccaga gacatggagt cataggctct     1800

ggaaagaccc tgaccatcac tgtcaaagag tttctagatg ctggccagta cacctgccac     1860

aaaggaggcg agactctgag ccactcacat ctgctgctcc acaagaagga aaatggaatt     1920

tggtccactg aaattttaaa aaatttcaaa aacaagactt tcctgaagtg tgaagcacca     1980

aattactccg gacggttcac gtgctcatgg ctggtgcaaa gaaacatgga cttgaagttc     2040

aacatcaaga gcagtagcag ttcccctgac tctcgggcag tgacatgtgg aatggcgtct     2100

ctgtctgcag agaaggtcac actggaccaa agggactatg agaagtattc agtgtcctgc     2160

caggaggatg tcacctgccc aactgccgag gagaccctgc ccattgaact ggcgttggaa     2220

gcacggcagc agaataaata tgagaactac agcaccagct tcttcatcag ggacatcatc     2280

aaaccagacc cgcccaagaa cttgcagatg aagcctttga agaactcaca ggtggaggtc     2340

agctgggagt accctgactc ctggagcact ccccattcct acttctccct caagttcttt     2400

gttcgaatcc agcgcaagaa agaaaagatg aaggagacag aggaggggtg taaccagaaa     2460

ggtgcgttcc tcgtagagaa gacatctacc gaagtccaat gcaaaggcgg gaatgtctgc     2520

gtgcaagctc aggatcgcta ttacaattcc tcgtgcagca agtgggcatg tgttccctgc     2580

agggtccgat cctag                                                      2595


<210>  42
<211>  2616
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aGMCSFIL12bIL2ĺ

<400>  42
atgtgtcaat cacgctacct cctctttttg gccacccttg ccctcctaaa ccacctcagt       60

ttggccaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg      120

ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc      180

actgctgaag acatcgatca tgaagacatc acacgggacc aaaccagcac attgaagacc      240

tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc      300

acaacaagag ggagctgcct gcccccacag aagacgtctt tgatgatgac cctgtgcctt      360

ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca      420

cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgctggt ggccatcgat      480

gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga      540

gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc      600

cgcgtcgtga ccatcaacag ggtgatgggc tatctgagct ccgccggtgg aggaggttct      660

ggaggcggtg gaagtggtgg cggaggtagc gcacccaccc gctcacccat cactgtcacc      720

cggccttgga agcatgtaga ggccatcaaa gaagccctga acctcctgga tgacatgcct      780

gtcacgttga atgaagaggt agaagtcgtc tctaacgagt tctccttcaa gaagctaaca      840

tgtgtgcaga cccgcctgaa gatattcgag cagggtctac ggggcaattt caccaaactc      900

aagggcgcct tgaacatgac agccagctac taccagacat actgcccccc aactccggaa      960

acggactgtg aaacacaagt taccacctat gcggatttca tagacagcct taaaaccttt     1020

ctgactgata tcccctttga atgcaaaaaa ccaggccaaa aagagggcag aggaagtctt     1080

ctaacatgcg gtgacgtgga ggagaatccc ggccctatgt gtcctcagaa gctaaccatc     1140

tcctggtttg ccatcgtttt gctggtgtct ccactcatgg ccatgtggga gctggagaaa     1200

gacgtttatg ttgtagaggt ggactggact cccgatgccc ctggagaaac agtgaacctc     1260

acctgtgaca cgcctgaaga agatgacatc acctggacct cagaccagag acatggagtc     1320

ataggctctg gaaagaccct gaccatcact gtcaaagagt ttctagatgc tggccagtac     1380

acctgccaca aaggaggcga gactctgagc cactcacatc tgctgctcca caagaaggaa     1440

aatggaattt ggtccactga aattttaaaa aatttcaaaa acaagacttt cctgaagtgt     1500

gaagcaccaa attactccgg acggttcacg tgctcatggc tggtgcaaag aaacatggac     1560

ttgaagttca acatcaagag cagtagcagt tcccctgact ctcgggcagt gacatgtgga     1620

atggcgtctc tgtctgcaga gaaggtcaca ctggaccaaa gggactatga gaagtattca     1680

gtgtcctgcc aggaggatgt cacctgccca actgccgagg agaccctgcc cattgaactg     1740

gcgttggaag cacggcagca gaataaatat gagaactaca gcaccagctt cttcatcagg     1800

gacatcatca aaccagaccc gcccaagaac ttgcagatga agcctttgaa gaactcacag     1860

gtggaggtca gctgggagta ccctgactcc tggagcactc cccattccta cttctccctc     1920

aagttctttg ttcgaatcca gcgcaagaaa gaaaagatga aggagacaga ggaggggtgt     1980

aaccagaaag gtgcgttcct cgtagagaag acatctaccg aagtccaatg caaaggcggg     2040

aatgtctgcg tgcaagctca ggatcgctat tacaattcct cgtgcagcaa gtgggcatgt     2100

gttccctgca gggtccgatc cggaggcggt ggaagtggcg gtggaggctc tggaggtggc     2160

ggaagcgcac ccacttcaag ctccacttca agctctacag cggaagcaca gcagcagcag     2220

cagcagcagc agcagcagca gcagcacctg gagcagctgt tgatggacct acaggagctc     2280

ctgagcagga tggagaatta caggaacctg aaactcccca ggatgctcac cttcaaattt     2340

tacttgccca agcaggccac agaattgaaa gatcttcagt gcctagaaga tgaacttgga     2400

cctctgcggc atgttctgga tttgactcaa agcaaaagct ttcaattgga agatgctgag     2460

aatttcatca gcaatatcag agtaactgtt gtaaaactaa agggctctga caacacattt     2520

gagtgccaat tcgatgatga gtcagcaact gtggtggact ttctgaggag atggatagcc     2580

ttctgtcaaa gcatcatctc aacaagccct caataa                               2616


<210>  43
<211>  2556
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL7IL12bGMCSFĺ

<400>  43
atgtgtcaat cacgctacct cctctttttg gccacccttg ccctcctaaa ccacctcagt       60

ttggccaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg      120

ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc      180

actgctgaag acatcgatca tgaagacatc acacgggacc aaaccagcac attgaagacc      240

tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc      300

acaacaagag ggagctgcct gcccccacag aagacgtctt tgatgatgac cctgtgcctt      360

ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca      420

cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgctggt ggccatcgat      480

gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga      540

gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc      600

cgcgtcgtga ccatcaacag ggtgatgggc tatctgagct ccgccggtgg aggaggttct      660

ggaggcggtg gaagtggtgg cggaggtagc gagtgccaca ttaaagacaa agaaggtaaa      720

gcatatgaga gtgtactgat gatcagcatc gatgaattgg acaaaatgac aggaactgat      780

agtaattgcc cgaataatga accaaacttt tttagaaaac atgtatgtga tgatacaaag      840

gaagctgctt ttctaaatcg tgctgctcgc aagttgaagc aatttcttaa aatgaatatc      900

agtgaagaat tcaatgtcca cttactaaca gtatcacaag gcacacaaac actggtgaac      960

tgcacaagta aggaagaaaa aaacgtaaag gaacagaaaa agaatgatgc atgtttccta     1020

aagagactac tgagagaaat aaaaacttgt tggaataaaa ttttgaaggg cagtatagag     1080

ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc tatgtgtcct     1140

cagaagctaa ccatctcctg gtttgccatc gttttgctgg tgtctccact catggccatg     1200

tgggagctgg agaaagacgt ttatgttgta gaggtggact ggactcccga tgcccctgga     1260

gaaacagtga acctcacctg tgacacgcct gaagaagatg acatcacctg gacctcagac     1320

cagagacatg gagtcatagg ctctggaaag accctgacca tcactgtcaa agagtttcta     1380

gatgctggcc agtacacctg ccacaaagga ggcgagactc tgagccactc acatctgctg     1440

ctccacaaga aggaaaatgg aatttggtcc actgaaattt taaaaaattt caaaaacaag     1500

actttcctga agtgtgaagc accaaattac tccggacggt tcacgtgctc atggctggtg     1560

caaagaaaca tggacttgaa gttcaacatc aagagcagta gcagttcccc tgactctcgg     1620

gcagtgacat gtggaatggc gtctctgtct gcagagaagg tcacactgga ccaaagggac     1680

tatgagaagt attcagtgtc ctgccaggag gatgtcacct gcccaactgc cgaggagacc     1740

ctgcccattg aactggcgtt ggaagcacgg cagcagaata aatatgagaa ctacagcacc     1800

agcttcttca tcagggacat catcaaacca gacccgccca agaacttgca gatgaagcct     1860

ttgaagaact cacaggtgga ggtcagctgg gagtaccctg actcctggag cactccccat     1920

tcctacttct ccctcaagtt ctttgttcga atccagcgca agaaagaaaa gatgaaggag     1980

acagaggagg ggtgtaacca gaaaggtgcg ttcctcgtag agaagacatc taccgaagtc     2040

caatgcaaag gcgggaatgt ctgcgtgcaa gctcaggatc gctattacaa ttcctcgtgc     2100

agcaagtggg catgtgttcc ctgcagggtc cgatccggag gcggtggaag tggcggtgga     2160

ggctctggag gtggcggaag cgcacccacc cgctcaccca tcactgtcac ccggccttgg     2220

aagcatgtag aggccatcaa agaagccctg aacctcctgg atgacatgcc tgtcacgttg     2280

aatgaagagg tagaagtcgt ctctaacgag ttctccttca agaagctaac atgtgtgcag     2340

acccgcctga agatattcga gcagggtcta cggggcaatt tcaccaaact caagggcgcc     2400

ttgaacatga cagccagcta ctaccagaca tactgccccc caactccgga aacggactgt     2460

gaaacacaag ttaccaccta tgcggatttc atagacagcc ttaaaacctt tctgactgat     2520

atcccctttg aatgcaaaaa accaggccaa aaatga                               2556


<210>  44
<211>  2568
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL15IL12bGMCSFĺ

<400>  44
atgtgtcaat cacgctacct cctctttttg gccacccttg ccctcctaaa ccacctcagt       60

ttggccaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg      120

ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc      180

actgctgaag acatcgatca tgaagacatc acacgggacc aaaccagcac attgaagacc      240

tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc      300

acaacaagag ggagctgcct gcccccacag aagacgtctt tgatgatgac cctgtgcctt      360

ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca      420

cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgctggt ggccatcgat      480

gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga      540

gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc      600

cgcgtcgtga ccatcaacag ggtgatgggc tatctgagct ccgccggtgg aggaggttct      660

ggaggcggtg gaagtggtgg cggaggtagc ggcattcatg tcttcatttt gggctgtgtc      720

agtgtaggtc tccctaaaac agaggccaac tggatagatg taagatatga cctggagaaa      780

attgaaagcc ttattcaatc tattcatatt gacaccactt tatacactga cagtgacttt      840

catcccagtt gcaaagttac tgcaatgaac tgctttctcc tggaattgca ggttatttta      900

catgagtaca gtaacatgac tcttaatgaa acagtaagaa acgtgctcta ccttgcaaac      960

agcactctgt cttctaacaa gaatgtagca gaatctggct gcaaggaatg tgaggagctg     1020

gaggagaaaa ccttcacaga gtttttgcaa agctttatac gcattgtcca aatgttcatc     1080

aacacgtccg agggcagagg aagtcttcta acatgcggtg acgtggagga gaatcccggc     1140

cctatgtgtc ctcagaagct aaccatctcc tggtttgcca tcgttttgct ggtgtctcca     1200

ctcatggcca tgtgggagct ggagaaagac gtttatgttg tagaggtgga ctggactccc     1260

gatgcccctg gagaaacagt gaacctcacc tgtgacacgc ctgaagaaga tgacatcacc     1320

tggacctcag accagagaca tggagtcata ggctctggaa agaccctgac catcactgtc     1380

aaagagtttc tagatgctgg ccagtacacc tgccacaaag gaggcgagac tctgagccac     1440

tcacatctgc tgctccacaa gaaggaaaat ggaatttggt ccactgaaat tttaaaaaat     1500

ttcaaaaaca agactttcct gaagtgtgaa gcaccaaatt actccggacg gttcacgtgc     1560

tcatggctgg tgcaaagaaa catggacttg aagttcaaca tcaagagcag tagcagttcc     1620

cctgactctc gggcagtgac atgtggaatg gcgtctctgt ctgcagagaa ggtcacactg     1680

gaccaaaggg actatgagaa gtattcagtg tcctgccagg aggatgtcac ctgcccaact     1740

gccgaggaga ccctgcccat tgaactggcg ttggaagcac ggcagcagaa taaatatgag     1800

aactacagca ccagcttctt catcagggac atcatcaaac cagacccgcc caagaacttg     1860

cagatgaagc ctttgaagaa ctcacaggtg gaggtcagct gggagtaccc tgactcctgg     1920

agcactcccc attcctactt ctccctcaag ttctttgttc gaatccagcg caagaaagaa     1980

aagatgaagg agacagagga ggggtgtaac cagaaaggtg cgttcctcgt agagaagaca     2040

tctaccgaag tccaatgcaa aggcgggaat gtctgcgtgc aagctcagga tcgctattac     2100

aattcctcgt gcagcaagtg ggcatgtgtt ccctgcaggg tccgatccgg aggcggtgga     2160

agtggcggtg gaggctctgg aggtggcgga agcgcaccca cccgctcacc catcactgtc     2220

acccggcctt ggaagcatgt agaggccatc aaagaagccc tgaacctcct ggatgacatg     2280

cctgtcacgt tgaatgaaga ggtagaagtc gtctctaacg agttctcctt caagaagcta     2340

acatgtgtgc agacccgcct gaagatattc gagcagggtc tacggggcaa tttcaccaaa     2400

ctcaagggcg ccttgaacat gacagccagc tactaccaga catactgccc cccaactccg     2460

gaaacggact gtgaaacaca agttaccacc tatgcggatt tcatagacag ccttaaaacc     2520

tttctgactg atatcccctt tgaatgcaaa aaaccaggcc aaaaatga                  2568


<210>  45
<211>  2556
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL21IL12bGMCSFĺ

<400>  45
atgtgtcaat cacgctacct cctctttttg gccacccttg ccctcctaaa ccacctcagt       60

ttggccaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg      120

ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc      180

actgctgaag acatcgatca tgaagacatc acacgggacc aaaccagcac attgaagacc      240

tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc      300

acaacaagag ggagctgcct gcccccacag aagacgtctt tgatgatgac cctgtgcctt      360

ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca      420

cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgctggt ggccatcgat      480

gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga      540

gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc      600

cgcgtcgtga ccatcaacag ggtgatgggc tatctgagct ccgccggtgg aggaggttct      660

ggaggcggtg gaagtggtgg cggaggtagc cataaatcaa gcccccaagg gccagatcgc      720

ctcctgatta gacttcgtca ccttattgac attgttgaac agctgaaaat ctatgaaaat      780

gacttggatc ctgaacttct atcagctcca caagatgtaa aggggcactg tgagcatgca      840

gcttttgcct gttttcagaa ggccaaactc aagccatcaa accctggaaa caataagaca      900

ttcatcattg acctcgtggc ccagctcagg aggaggctgc ctgccaggag gggaggaaag      960

aaacagaagc acatagctaa atgcccttcc tgtgattcgt atgagaaaag gacacccaaa     1020

gaattcctag aaagactaaa atggctcctt caaaagatga ttcatcagca tctctccgag     1080

ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc tatgtgtcct     1140

cagaagctaa ccatctcctg gtttgccatc gttttgctgg tgtctccact catggccatg     1200

tgggagctgg agaaagacgt ttatgttgta gaggtggact ggactcccga tgcccctgga     1260

gaaacagtga acctcacctg tgacacgcct gaagaagatg acatcacctg gacctcagac     1320

cagagacatg gagtcatagg ctctggaaag accctgacca tcactgtcaa agagtttcta     1380

gatgctggcc agtacacctg ccacaaagga ggcgagactc tgagccactc acatctgctg     1440

ctccacaaga aggaaaatgg aatttggtcc actgaaattt taaaaaattt caaaaacaag     1500

actttcctga agtgtgaagc accaaattac tccggacggt tcacgtgctc atggctggtg     1560

caaagaaaca tggacttgaa gttcaacatc aagagcagta gcagttcccc tgactctcgg     1620

gcagtgacat gtggaatggc gtctctgtct gcagagaagg tcacactgga ccaaagggac     1680

tatgagaagt attcagtgtc ctgccaggag gatgtcacct gcccaactgc cgaggagacc     1740

ctgcccattg aactggcgtt ggaagcacgg cagcagaata aatatgagaa ctacagcacc     1800

agcttcttca tcagggacat catcaaacca gacccgccca agaacttgca gatgaagcct     1860

ttgaagaact cacaggtgga ggtcagctgg gagtaccctg actcctggag cactccccat     1920

tcctacttct ccctcaagtt ctttgttcga atccagcgca agaaagaaaa gatgaaggag     1980

acagaggagg ggtgtaacca gaaaggtgcg ttcctcgtag agaagacatc taccgaagtc     2040

caatgcaaag gcgggaatgt ctgcgtgcaa gctcaggatc gctattacaa ttcctcgtgc     2100

agcaagtggg catgtgttcc ctgcagggtc cgatccggag gcggtggaag tggcggtgga     2160

ggctctggag gtggcggaag cgcacccacc cgctcaccca tcactgtcac ccggccttgg     2220

aagcatgtag aggccatcaa agaagccctg aacctcctgg atgacatgcc tgtcacgttg     2280

aatgaagagg tagaagtcgt ctctaacgag ttctccttca agaagctaac atgtgtgcag     2340

acccgcctga agatattcga gcagggtcta cggggcaatt tcaccaaact caagggcgcc     2400

ttgaacatga cagccagcta ctaccagaca tactgccccc caactccgga aacggactgt     2460

gaaacacaag ttaccaccta tgcggatttc atagacagcc ttaaaacctt tctgactgat     2520

atcccctttg aatgcaaaaa accaggccaa aaatga                               2556


<210>  46
<211>  2862
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL2IL12bFLT3Lĺ

<400>  46
atgtgtcaat cacgctacct cctctttttg gccacccttg ccctcctaaa ccacctcagt       60

ttggccaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg      120

ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc      180

actgctgaag acatcgatca tgaagacatc acacgggacc aaaccagcac attgaagacc      240

tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc      300

acaacaagag ggagctgcct gcccccacag aagacgtctt tgatgatgac cctgtgcctt      360

ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca      420

cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgctggt ggccatcgat      480

gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga      540

gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc      600

cgcgtcgtga ccatcaacag ggtgatgggc tatctgagct ccgccggtgg aggaggttct      660

ggaggcggtg gaagtggtgg cggaggtagc gcacccactt caagctccac ttcaagctct      720

acagcggaag cacagcagca gcagcagcag cagcagcagc agcagcagca cctggagcag      780

ctgttgatgg acctacagga gctcctgagc aggatggaga attacaggaa cctgaaactc      840

cccaggatgc tcaccttcaa attttacttg cccaagcagg ccacagaatt gaaagatctt      900

cagtgcctag aagatgaact tggacctctg cggcatgttc tggatttgac tcaaagcaaa      960

agctttcaat tggaagatgc tgagaatttc atcagcaata tcagagtaac tgttgtaaaa     1020

ctaaagggct ctgacaacac atttgagtgc caattcgatg atgagtcagc aactgtggtg     1080

gactttctga ggagatggat agccttctgt caaagcatca tctcaacaag ccctcaagag     1140

ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc tatgtgtcct     1200

cagaagctaa ccatctcctg gtttgccatc gttttgctgg tgtctccact catggccatg     1260

tgggagctgg agaaagacgt ttatgttgta gaggtggact ggactcccga tgcccctgga     1320

gaaacagtga acctcacctg tgacacgcct gaagaagatg acatcacctg gacctcagac     1380

cagagacatg gagtcatagg ctctggaaag accctgacca tcactgtcaa agagtttcta     1440

gatgctggcc agtacacctg ccacaaagga ggcgagactc tgagccactc acatctgctg     1500

ctccacaaga aggaaaatgg aatttggtcc actgaaattt taaaaaattt caaaaacaag     1560

actttcctga agtgtgaagc accaaattac tccggacggt tcacgtgctc atggctggtg     1620

caaagaaaca tggacttgaa gttcaacatc aagagcagta gcagttcccc tgactctcgg     1680

gcagtgacat gtggaatggc gtctctgtct gcagagaagg tcacactgga ccaaagggac     1740

tatgagaagt attcagtgtc ctgccaggag gatgtcacct gcccaactgc cgaggagacc     1800

ctgcccattg aactggcgtt ggaagcacgg cagcagaata aatatgagaa ctacagcacc     1860

agcttcttca tcagggacat catcaaacca gacccgccca agaacttgca gatgaagcct     1920

ttgaagaact cacaggtgga ggtcagctgg gagtaccctg actcctggag cactccccat     1980

tcctacttct ccctcaagtt ctttgttcga atccagcgca agaaagaaaa gatgaaggag     2040

acagaggagg ggtgtaacca gaaaggtgcg ttcctcgtag agaagacatc taccgaagtc     2100

caatgcaaag gcgggaatgt ctgcgtgcaa gctcaggatc gctattacaa ttcctcgtgc     2160

agcaagtggg catgtgttcc ctgcagggtc cgatccggag gcggtggaag tggcggtgga     2220

ggctctggag gtggcggaag cgggacacct gactgttact tcagccacag tcccatctcc     2280

tccaacttca aagtgaagtt tagagagttg actgaccacc tgcttaaaga ttacccagtc     2340

actgtggccg tcaatcttca ggacgagaag cactgcaagg ccttgtggag cctcttccta     2400

gcccagcgct ggatagagca actgaagact gtggcagggt ctaagatgca aacgcttctg     2460

gaggacgtca acaccgagat acattttgtc acctcatgta ccttccagcc cctaccagaa     2520

tgtctgcgat tcgtccagac caacatctcc cacctcctga aggacacctg cacacagctg     2580

cttgctctga agccctgtat cgggaaggcc tgccagaatt tctctcggtg cctggaggtg     2640

cagtgccagc cggactcctc caccctgctg cccccaagga gtcccatagc cctagaagcc     2700

acggagctcc cagagcctcg gcccaggcag ctgttgctcc tgctgctgct gctgctgcct     2760

ctcacactgg tgctgctggc agccgcctgg ggccttcgct ggcaaagggc aagaaggagg     2820

ggggagctcc accctggggt gcccctcccc tcccatccct ag                        2862


<210>  47
<211>  2802
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL7IL12bFLT3Lĺ

<400>  47
atgtgtcaat cacgctacct cctctttttg gccacccttg ccctcctaaa ccacctcagt       60

ttggccaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg      120

ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc      180

actgctgaag acatcgatca tgaagacatc acacgggacc aaaccagcac attgaagacc      240

tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc      300

acaacaagag ggagctgcct gcccccacag aagacgtctt tgatgatgac cctgtgcctt      360

ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca      420

cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgctggt ggccatcgat      480

gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga      540

gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc      600

cgcgtcgtga ccatcaacag ggtgatgggc tatctgagct ccgccggtgg aggaggttct      660

ggaggcggtg gaagtggtgg cggaggtagc gagtgccaca ttaaagacaa agaaggtaaa      720

gcatatgaga gtgtactgat gatcagcatc gatgaattgg acaaaatgac aggaactgat      780

agtaattgcc cgaataatga accaaacttt tttagaaaac atgtatgtga tgatacaaag      840

gaagctgctt ttctaaatcg tgctgctcgc aagttgaagc aatttcttaa aatgaatatc      900

agtgaagaat tcaatgtcca cttactaaca gtatcacaag gcacacaaac actggtgaac      960

tgcacaagta aggaagaaaa aaacgtaaag gaacagaaaa agaatgatgc atgtttccta     1020

aagagactac tgagagaaat aaaaacttgt tggaataaaa ttttgaaggg cagtatagag     1080

ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc tatgtgtcct     1140

cagaagctaa ccatctcctg gtttgccatc gttttgctgg tgtctccact catggccatg     1200

tgggagctgg agaaagacgt ttatgttgta gaggtggact ggactcccga tgcccctgga     1260

gaaacagtga acctcacctg tgacacgcct gaagaagatg acatcacctg gacctcagac     1320

cagagacatg gagtcatagg ctctggaaag accctgacca tcactgtcaa agagtttcta     1380

gatgctggcc agtacacctg ccacaaagga ggcgagactc tgagccactc acatctgctg     1440

ctccacaaga aggaaaatgg aatttggtcc actgaaattt taaaaaattt caaaaacaag     1500

actttcctga agtgtgaagc accaaattac tccggacggt tcacgtgctc atggctggtg     1560

caaagaaaca tggacttgaa gttcaacatc aagagcagta gcagttcccc tgactctcgg     1620

gcagtgacat gtggaatggc gtctctgtct gcagagaagg tcacactgga ccaaagggac     1680

tatgagaagt attcagtgtc ctgccaggag gatgtcacct gcccaactgc cgaggagacc     1740

ctgcccattg aactggcgtt ggaagcacgg cagcagaata aatatgagaa ctacagcacc     1800

agcttcttca tcagggacat catcaaacca gacccgccca agaacttgca gatgaagcct     1860

ttgaagaact cacaggtgga ggtcagctgg gagtaccctg actcctggag cactccccat     1920

tcctacttct ccctcaagtt ctttgttcga atccagcgca agaaagaaaa gatgaaggag     1980

acagaggagg ggtgtaacca gaaaggtgcg ttcctcgtag agaagacatc taccgaagtc     2040

caatgcaaag gcgggaatgt ctgcgtgcaa gctcaggatc gctattacaa ttcctcgtgc     2100

agcaagtggg catgtgttcc ctgcagggtc cgatccggag gcggtggaag tggcggtgga     2160

ggctctggag gtggcggaag cgggacacct gactgttact tcagccacag tcccatctcc     2220

tccaacttca aagtgaagtt tagagagttg actgaccacc tgcttaaaga ttacccagtc     2280

actgtggccg tcaatcttca ggacgagaag cactgcaagg ccttgtggag cctcttccta     2340

gcccagcgct ggatagagca actgaagact gtggcagggt ctaagatgca aacgcttctg     2400

gaggacgtca acaccgagat acattttgtc acctcatgta ccttccagcc cctaccagaa     2460

tgtctgcgat tcgtccagac caacatctcc cacctcctga aggacacctg cacacagctg     2520

cttgctctga agccctgtat cgggaaggcc tgccagaatt tctctcggtg cctggaggtg     2580

cagtgccagc cggactcctc caccctgctg cccccaagga gtcccatagc cctagaagcc     2640

acggagctcc cagagcctcg gcccaggcag ctgttgctcc tgctgctgct gctgctgcct     2700

ctcacactgg tgctgctggc agccgcctgg ggccttcgct ggcaaagggc aagaaggagg     2760

ggggagctcc accctggggt gcccctcccc tcccatccct ag                        2802


<210>  48
<211>  2814
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL15IL12bFLT3Lĺ

<400>  48
atgtgtcaat cacgctacct cctctttttg gccacccttg ccctcctaaa ccacctcagt       60

ttggccaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg      120

ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc      180

actgctgaag acatcgatca tgaagacatc acacgggacc aaaccagcac attgaagacc      240

tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc      300

acaacaagag ggagctgcct gcccccacag aagacgtctt tgatgatgac cctgtgcctt      360

ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca      420

cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgctggt ggccatcgat      480

gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga      540

gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc      600

cgcgtcgtga ccatcaacag ggtgatgggc tatctgagct ccgccggtgg aggaggttct      660

ggaggcggtg gaagtggtgg cggaggtagc ggcattcatg tcttcatttt gggctgtgtc      720

agtgtaggtc tccctaaaac agaggccaac tggatagatg taagatatga cctggagaaa      780

attgaaagcc ttattcaatc tattcatatt gacaccactt tatacactga cagtgacttt      840

catcccagtt gcaaagttac tgcaatgaac tgctttctcc tggaattgca ggttatttta      900

catgagtaca gtaacatgac tcttaatgaa acagtaagaa acgtgctcta ccttgcaaac      960

agcactctgt cttctaacaa gaatgtagca gaatctggct gcaaggaatg tgaggagctg     1020

gaggagaaaa ccttcacaga gtttttgcaa agctttatac gcattgtcca aatgttcatc     1080

aacacgtccg agggcagagg aagtcttcta acatgcggtg acgtggagga gaatcccggc     1140

cctatgtgtc ctcagaagct aaccatctcc tggtttgcca tcgttttgct ggtgtctcca     1200

ctcatggcca tgtgggagct ggagaaagac gtttatgttg tagaggtgga ctggactccc     1260

gatgcccctg gagaaacagt gaacctcacc tgtgacacgc ctgaagaaga tgacatcacc     1320

tggacctcag accagagaca tggagtcata ggctctggaa agaccctgac catcactgtc     1380

aaagagtttc tagatgctgg ccagtacacc tgccacaaag gaggcgagac tctgagccac     1440

tcacatctgc tgctccacaa gaaggaaaat ggaatttggt ccactgaaat tttaaaaaat     1500

ttcaaaaaca agactttcct gaagtgtgaa gcaccaaatt actccggacg gttcacgtgc     1560

tcatggctgg tgcaaagaaa catggacttg aagttcaaca tcaagagcag tagcagttcc     1620

cctgactctc gggcagtgac atgtggaatg gcgtctctgt ctgcagagaa ggtcacactg     1680

gaccaaaggg actatgagaa gtattcagtg tcctgccagg aggatgtcac ctgcccaact     1740

gccgaggaga ccctgcccat tgaactggcg ttggaagcac ggcagcagaa taaatatgag     1800

aactacagca ccagcttctt catcagggac atcatcaaac cagacccgcc caagaacttg     1860

cagatgaagc ctttgaagaa ctcacaggtg gaggtcagct gggagtaccc tgactcctgg     1920

agcactcccc attcctactt ctccctcaag ttctttgttc gaatccagcg caagaaagaa     1980

aagatgaagg agacagagga ggggtgtaac cagaaaggtg cgttcctcgt agagaagaca     2040

tctaccgaag tccaatgcaa aggcgggaat gtctgcgtgc aagctcagga tcgctattac     2100

aattcctcgt gcagcaagtg ggcatgtgtt ccctgcaggg tccgatccgg aggcggtgga     2160

agtggcggtg gaggctctgg aggtggcgga agcgggacac ctgactgtta cttcagccac     2220

agtcccatct cctccaactt caaagtgaag tttagagagt tgactgacca cctgcttaaa     2280

gattacccag tcactgtggc cgtcaatctt caggacgaga agcactgcaa ggccttgtgg     2340

agcctcttcc tagcccagcg ctggatagag caactgaaga ctgtggcagg gtctaagatg     2400

caaacgcttc tggaggacgt caacaccgag atacattttg tcacctcatg taccttccag     2460

cccctaccag aatgtctgcg attcgtccag accaacatct cccacctcct gaaggacacc     2520

tgcacacagc tgcttgctct gaagccctgt atcgggaagg cctgccagaa tttctctcgg     2580

tgcctggagg tgcagtgcca gccggactcc tccaccctgc tgcccccaag gagtcccata     2640

gccctagaag ccacggagct cccagagcct cggcccaggc agctgttgct cctgctgctg     2700

ctgctgctgc ctctcacact ggtgctgctg gcagccgcct ggggccttcg ctggcaaagg     2760

gcaagaagga ggggggagct ccaccctggg gtgcccctcc cctcccatcc ctag           2814


<210>  49
<211>  2802
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12aIL21IL12bFLT3Lĺ

<400>  49
atgtgtcaat cacgctacct cctctttttg gccacccttg ccctcctaaa ccacctcagt       60

ttggccaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg      120

ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc      180

actgctgaag acatcgatca tgaagacatc acacgggacc aaaccagcac attgaagacc      240

tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc      300

acaacaagag ggagctgcct gcccccacag aagacgtctt tgatgatgac cctgtgcctt      360

ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca      420

cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgctggt ggccatcgat      480

gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga      540

gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc      600

cgcgtcgtga ccatcaacag ggtgatgggc tatctgagct ccgccggtgg aggaggttct      660

ggaggcggtg gaagtggtgg cggaggtagc cataaatcaa gcccccaagg gccagatcgc      720

ctcctgatta gacttcgtca ccttattgac attgttgaac agctgaaaat ctatgaaaat      780

gacttggatc ctgaacttct atcagctcca caagatgtaa aggggcactg tgagcatgca      840

gcttttgcct gttttcagaa ggccaaactc aagccatcaa accctggaaa caataagaca      900

ttcatcattg acctcgtggc ccagctcagg aggaggctgc ctgccaggag gggaggaaag      960

aaacagaagc acatagctaa atgcccttcc tgtgattcgt atgagaaaag gacacccaaa     1020

gaattcctag aaagactaaa atggctcctt caaaagatga ttcatcagca tctctccgag     1080

ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc tatgtgtcct     1140

cagaagctaa ccatctcctg gtttgccatc gttttgctgg tgtctccact catggccatg     1200

tgggagctgg agaaagacgt ttatgttgta gaggtggact ggactcccga tgcccctgga     1260

gaaacagtga acctcacctg tgacacgcct gaagaagatg acatcacctg gacctcagac     1320

cagagacatg gagtcatagg ctctggaaag accctgacca tcactgtcaa agagtttcta     1380

gatgctggcc agtacacctg ccacaaagga ggcgagactc tgagccactc acatctgctg     1440

ctccacaaga aggaaaatgg aatttggtcc actgaaattt taaaaaattt caaaaacaag     1500

actttcctga agtgtgaagc accaaattac tccggacggt tcacgtgctc atggctggtg     1560

caaagaaaca tggacttgaa gttcaacatc aagagcagta gcagttcccc tgactctcgg     1620

gcagtgacat gtggaatggc gtctctgtct gcagagaagg tcacactgga ccaaagggac     1680

tatgagaagt attcagtgtc ctgccaggag gatgtcacct gcccaactgc cgaggagacc     1740

ctgcccattg aactggcgtt ggaagcacgg cagcagaata aatatgagaa ctacagcacc     1800

agcttcttca tcagggacat catcaaacca gacccgccca agaacttgca gatgaagcct     1860

ttgaagaact cacaggtgga ggtcagctgg gagtaccctg actcctggag cactccccat     1920

tcctacttct ccctcaagtt ctttgttcga atccagcgca agaaagaaaa gatgaaggag     1980

acagaggagg ggtgtaacca gaaaggtgcg ttcctcgtag agaagacatc taccgaagtc     2040

caatgcaaag gcgggaatgt ctgcgtgcaa gctcaggatc gctattacaa ttcctcgtgc     2100

agcaagtggg catgtgttcc ctgcagggtc cgatccggag gcggtggaag tggcggtgga     2160

ggctctggag gtggcggaag cgggacacct gactgttact tcagccacag tcccatctcc     2220

tccaacttca aagtgaagtt tagagagttg actgaccacc tgcttaaaga ttacccagtc     2280

actgtggccg tcaatcttca ggacgagaag cactgcaagg ccttgtggag cctcttccta     2340

gcccagcgct ggatagagca actgaagact gtggcagggt ctaagatgca aacgcttctg     2400

gaggacgtca acaccgagat acattttgtc acctcatgta ccttccagcc cctaccagaa     2460

tgtctgcgat tcgtccagac caacatctcc cacctcctga aggacacctg cacacagctg     2520

cttgctctga agccctgtat cgggaaggcc tgccagaatt tctctcggtg cctggaggtg     2580

cagtgccagc cggactcctc caccctgctg cccccaagga gtcccatagc cctagaagcc     2640

acggagctcc cagagcctcg gcccaggcag ctgttgctcc tgctgctgct gctgctgcct     2700

ctcacactgg tgctgctggc agccgcctgg ggccttcgct ggcaaagggc aagaaggagg     2760

ggggagctcc accctggggt gcccctcccc tcccatccct ag                        2802


<210>  50
<211>  2670
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL2IL12bGMCSFĺ

<400>  50
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg       60

catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc      120

ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc      180

gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg      240

gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct      300

gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta      360

ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact      420

aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt      480

atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg      540

atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg      600

atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg      660

gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca      720

gtgactattg atagagtgat gagctatctg aatgcttccg gtggaggagg ttctggaggc      780

ggtggaagtg gtggcggagg tagcgcacct acttcaagtt ctacaaagaa aacacagcta      840

caactggagc atttactgct ggatttacag atgattttga atggaattaa taattacaag      900

aatcccaaac tcaccaggat gctcacattt aagttttaca tgcccaagaa ggccacagaa      960

ctgaaacatc ttcagtgtct agaagaagaa ctcaaacctc tggaggaagt gctaaattta     1020

gctcaaagca aaaactttca cttaagaccc agggacttaa tcagcaatat caacgtaata     1080

gttctggaac taaagggatc tgaaacaaca ttcatgtgtg aatatgctga tgagacagca     1140

accattgtag aatttctgaa cagatggatt accttttgtc aaagcatcat ctcaacactg     1200

actgagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc cggccctatg     1260

tgtcaccagc agttggtcat ctcttggttt tccctggttt ttctggcatc tcccctcgtg     1320

gccatatggg aactgaagaa agatgtttat gtcgtagaat tggattggta tccggatgcc     1380

cctggagaaa tggtggtcct cacctgtgac acccctgaag aagatggtat cacctggacc     1440

ttggaccaga gcagtgaggt cttaggctct ggcaaaaccc tgaccatcca agtcaaagag     1500

tttggagatg ctggccagta cacctgtcac aaaggaggcg aggttctaag ccattcgctc     1560

ctgctgcttc acaaaaagga agatggaatt tggtccactg atattttaaa ggaccagaaa     1620

gaacccaaaa ataagacctt tctaagatgc gaggccaaga attattctgg acgtttcacc     1680

tgctggtggc tgacgacaat cagtactgat ttgacattca gtgtcaaaag cagcagaggc     1740

tcttctgacc cccaaggggt gacgtgcgga gctgctacac tctctgcaga gagagtcaga     1800

ggggacaaca aggagtatga gtactcagtg gagtgccagg aggacagtgc ctgcccagct     1860

gctgaggaga gtctgcccat tgaggtcatg gtggatgccg ttcacaagct caagtatgaa     1920

aactacacca gcagcttctt catcagggac atcatcaaac ctgacccacc caagaacttg     1980

cagctgaagc cattaaagaa ttctcggcag gtggaggtca gctgggagta ccctgacacc     2040

tggagtactc cacattccta cttctccctg acattctgcg ttcaggtcca gggcaagagc     2100

aagagagaaa agaaagatag agtcttcacg gacaagacct cagccacggt catctgccgc     2160

aaaaatgcca gcattagcgt gcgggcccag gaccgctact atagctcatc ttggagcgaa     2220

tgggcatctg tgccctgcag tggaggcggt ggaagtggcg gtggaggctc tggaggtggc     2280

ggaagcgcac ccgcccgctc gcccagcccc agcacgcagc cctgggagca tgtgaatgcc     2340

atccaggagg cccggcgtct cctgaacctg agtagagaca ctgctgctga gatgaatgaa     2400

acagtagaag tcatctcaga aatgtttgac ctccaggagc cgacctgcct acagacccgc     2460

ctggagctgt acaagcaggg cctgcggggc agcctcacca agctcaaggg ccccttgacc     2520

atgatggcca gccactacaa gcagcactgc cctccaaccc cggaaacttc ctgtgcaacc     2580

cagattatca cctttgaaag tttcaaagag aacctgaagg actttctgct tgtcatcccc     2640

tttgactgct gggagccagt ccaggagtga                                      2670


<210>  51
<211>  2727
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL7IL12bGMCSFĺ

<400>  51
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg       60

catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc      120

ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc      180

gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg      240

gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct      300

gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta      360

ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact      420

aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt      480

atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg      540

atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg      600

atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg      660

gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca      720

gtgactattg atagagtgat gagctatctg aatgcttccg gtggaggagg ttctggaggc      780

ggtggaagtg gtggcggagg tagcgattgt gatattgaag gtaaagatgg caaacaatat      840

gagagtgttc taatggtcag catcgatcaa ttattggaca gcatgaaaga aattggtagc      900

aattgcctga ataatgaatt taactttttt aaaagacata tctgtgatgc taataaggaa      960

ggtatgtttt tattccgtgc tgctcgcaag ttgaggcaat ttcttaaaat gaatagcact     1020

ggtgattttg atctccactt attaaaagtt tcagaaggca caacaatact gttgaactgc     1080

actggccagg ttaaaggaag aaaaccagct gccctgggtg aagcccaacc aacaaagagt     1140

ttggaagaaa ataaatcttt aaaggaacag aaaaaactga atgacttgtg tttcctaaag     1200

agactattac aagagataaa aacttgttgg aataaaattt tgatgggcac taaagaacac     1260

gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccctatgtgt     1320

caccagcagt tggtcatctc ttggttttcc ctggtttttc tggcatctcc cctcgtggcc     1380

atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct     1440

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg     1500

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt     1560

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg     1620

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa     1680

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc     1740

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct     1800

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg     1860

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct     1920

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac     1980

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag     2040

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg     2100

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag     2160

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa     2220

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg     2280

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga     2340

agcgcacccg cccgctcgcc cagccccagc acgcagccct gggagcatgt gaatgccatc     2400

caggaggccc ggcgtctcct gaacctgagt agagacactg ctgctgagat gaatgaaaca     2460

gtagaagtca tctcagaaat gtttgacctc caggagccga cctgcctaca gacccgcctg     2520

gagctgtaca agcagggcct gcggggcagc ctcaccaagc tcaagggccc cttgaccatg     2580

atggccagcc actacaagca gcactgccct ccaaccccgg aaacttcctg tgcaacccag     2640

attatcacct ttgaaagttt caaagagaac ctgaaggact ttctgcttgt catccccttt     2700

gactgctggg agccagtcca ggagtga                                         2727


<210>  52
<211>  2670
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL15IL12bGMCSFĺ

<400>  52
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg       60

catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc      120

ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc      180

gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg      240

gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct      300

gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta      360

ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact      420

aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt      480

atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg      540

atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg      600

atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg      660

gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca      720

gtgactattg atagagtgat gagctatctg aatgcttccg gtggaggagg ttctggaggc      780

ggtggaagtg gtggcggagg tagcggcatt catgtcttca ttttgggctg tttcagtgca      840

gggcttccta aaacagaagc caactgggtg aatgtaataa gtgatttgaa aaaaattgaa      900

gatcttattc aatctatgca tattgatgct actttatata cggaaagtga tgttcacccc      960

agttgcaaag taacagcaat gaagtgcttt ctcttggagt tacaagttat ttcacttgag     1020

tccggagatg caagtattca tgatacagta gaaaatctga tcatcctagc aaacaacagt     1080

ttgtcttcta atgggaatgt aacagaatct ggatgcaaag aatgtgagga actggaggaa     1140

aaaaatatta aagaattttt gcagagtttt gtacatattg tccaaatgtt catcaacact     1200

tctgagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc cggccctatg     1260

tgtcaccagc agttggtcat ctcttggttt tccctggttt ttctggcatc tcccctcgtg     1320

gccatatggg aactgaagaa agatgtttat gtcgtagaat tggattggta tccggatgcc     1380

cctggagaaa tggtggtcct cacctgtgac acccctgaag aagatggtat cacctggacc     1440

ttggaccaga gcagtgaggt cttaggctct ggcaaaaccc tgaccatcca agtcaaagag     1500

tttggagatg ctggccagta cacctgtcac aaaggaggcg aggttctaag ccattcgctc     1560

ctgctgcttc acaaaaagga agatggaatt tggtccactg atattttaaa ggaccagaaa     1620

gaacccaaaa ataagacctt tctaagatgc gaggccaaga attattctgg acgtttcacc     1680

tgctggtggc tgacgacaat cagtactgat ttgacattca gtgtcaaaag cagcagaggc     1740

tcttctgacc cccaaggggt gacgtgcgga gctgctacac tctctgcaga gagagtcaga     1800

ggggacaaca aggagtatga gtactcagtg gagtgccagg aggacagtgc ctgcccagct     1860

gctgaggaga gtctgcccat tgaggtcatg gtggatgccg ttcacaagct caagtatgaa     1920

aactacacca gcagcttctt catcagggac atcatcaaac ctgacccacc caagaacttg     1980

cagctgaagc cattaaagaa ttctcggcag gtggaggtca gctgggagta ccctgacacc     2040

tggagtactc cacattccta cttctccctg acattctgcg ttcaggtcca gggcaagagc     2100

aagagagaaa agaaagatag agtcttcacg gacaagacct cagccacggt catctgccgc     2160

aaaaatgcca gcattagcgt gcgggcccag gaccgctact atagctcatc ttggagcgaa     2220

tgggcatctg tgccctgcag tggaggcggt ggaagtggcg gtggaggctc tggaggtggc     2280

ggaagcgcac ccgcccgctc gcccagcccc agcacgcagc cctgggagca tgtgaatgcc     2340

atccaggagg cccggcgtct cctgaacctg agtagagaca ctgctgctga gatgaatgaa     2400

acagtagaag tcatctcaga aatgtttgac ctccaggagc cgacctgcct acagacccgc     2460

ctggagctgt acaagcaggg cctgcggggc agcctcacca agctcaaggg ccccttgacc     2520

atgatggcca gccactacaa gcagcactgc cctccaaccc cggaaacttc ctgtgcaacc     2580

cagattatca cctttgaaag tttcaaagag aacctgaagg actttctgct tgtcatcccc     2640

tttgactgct gggagccagt ccaggagtga                                      2670


<210>  53
<211>  2670
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL21IL12bGMCSFĺ

<400>  53
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg       60

catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc      120

ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc      180

gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg      240

gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct      300

gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta      360

ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact      420

aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt      480

atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg      540

atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg      600

atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg      660

gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca      720

gtgactattg atagagtgat gagctatctg aatgcttccg gtggaggagg ttctggaggc      780

ggtggaagtg gtggcggagg tagccaaggt caagatcgcc acatgattag aatgcgtcaa      840

cttatagata ttgttgatca gctgaaaaat tatgtgaatg acttggtccc tgaatttctg      900

ccagctccag aagatgtaga gacaaactgt gagtggtcag ctttttcctg ctttcagaag      960

gcccaactaa agtcagcaaa tacaggaaac aatgaaagga taatcaatgt atcaattaaa     1020

aagctgaaga ggaaaccacc ttccacaaat gcagggagaa gacagaaaca cagactaaca     1080

tgcccttcat gtgattctta tgagaaaaaa ccacccaaag aattcctaga aagattcaaa     1140

tcacttctcc aaaagatgat tcatcagcat ctgtcctcta gaacacacgg aagtgaagat     1200

tccgagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc cggccctatg     1260

tgtcaccagc agttggtcat ctcttggttt tccctggttt ttctggcatc tcccctcgtg     1320

gccatatggg aactgaagaa agatgtttat gtcgtagaat tggattggta tccggatgcc     1380

cctggagaaa tggtggtcct cacctgtgac acccctgaag aagatggtat cacctggacc     1440

ttggaccaga gcagtgaggt cttaggctct ggcaaaaccc tgaccatcca agtcaaagag     1500

tttggagatg ctggccagta cacctgtcac aaaggaggcg aggttctaag ccattcgctc     1560

ctgctgcttc acaaaaagga agatggaatt tggtccactg atattttaaa ggaccagaaa     1620

gaacccaaaa ataagacctt tctaagatgc gaggccaaga attattctgg acgtttcacc     1680

tgctggtggc tgacgacaat cagtactgat ttgacattca gtgtcaaaag cagcagaggc     1740

tcttctgacc cccaaggggt gacgtgcgga gctgctacac tctctgcaga gagagtcaga     1800

ggggacaaca aggagtatga gtactcagtg gagtgccagg aggacagtgc ctgcccagct     1860

gctgaggaga gtctgcccat tgaggtcatg gtggatgccg ttcacaagct caagtatgaa     1920

aactacacca gcagcttctt catcagggac atcatcaaac ctgacccacc caagaacttg     1980

cagctgaagc cattaaagaa ttctcggcag gtggaggtca gctgggagta ccctgacacc     2040

tggagtactc cacattccta cttctccctg acattctgcg ttcaggtcca gggcaagagc     2100

aagagagaaa agaaagatag agtcttcacg gacaagacct cagccacggt catctgccgc     2160

aaaaatgcca gcattagcgt gcgggcccag gaccgctact atagctcatc ttggagcgaa     2220

tgggcatctg tgccctgcag tggaggcggt ggaagtggcg gtggaggctc tggaggtggc     2280

ggaagcgcac ccgcccgctc gcccagcccc agcacgcagc cctgggagca tgtgaatgcc     2340

atccaggagg cccggcgtct cctgaacctg agtagagaca ctgctgctga gatgaatgaa     2400

acagtagaag tcatctcaga aatgtttgac ctccaggagc cgacctgcct acagacccgc     2460

ctggagctgt acaagcaggg cctgcggggc agcctcacca agctcaaggg ccccttgacc     2520

atgatggcca gccactacaa gcagcactgc cctccaaccc cggaaacttc ctgtgcaacc     2580

cagattatca cctttgaaag tttcaaagag aacctgaagg actttctgct tgtcatcccc     2640

tttgactgct gggagccagt ccaggagtga                                      2670


<210>  54
<211>  2916
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL2IL12bFLT3Lĺ

<400>  54
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg       60

catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc      120

ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc      180

gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg      240

gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct      300

gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta      360

ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact      420

aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt      480

atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg      540

atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg      600

atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg      660

gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca      720

gtgactattg atagagtgat gagctatctg aatgcttccg gtggaggagg ttctggaggc      780

ggtggaagtg gtggcggagg tagcgcacct acttcaagtt ctacaaagaa aacacagcta      840

caactggagc atttactgct ggatttacag atgattttga atggaattaa taattacaag      900

aatcccaaac tcaccaggat gctcacattt aagttttaca tgcccaagaa ggccacagaa      960

ctgaaacatc ttcagtgtct agaagaagaa ctcaaacctc tggaggaagt gctaaattta     1020

gctcaaagca aaaactttca cttaagaccc agggacttaa tcagcaatat caacgtaata     1080

gttctggaac taaagggatc tgaaacaaca ttcatgtgtg aatatgctga tgagacagca     1140

accattgtag aatttctgaa cagatggatt accttttgtc aaagcatcat ctcaacactg     1200

actgagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc cggccctatg     1260

tgtcaccagc agttggtcat ctcttggttt tccctggttt ttctggcatc tcccctcgtg     1320

gccatatggg aactgaagaa agatgtttat gtcgtagaat tggattggta tccggatgcc     1380

cctggagaaa tggtggtcct cacctgtgac acccctgaag aagatggtat cacctggacc     1440

ttggaccaga gcagtgaggt cttaggctct ggcaaaaccc tgaccatcca agtcaaagag     1500

tttggagatg ctggccagta cacctgtcac aaaggaggcg aggttctaag ccattcgctc     1560

ctgctgcttc acaaaaagga agatggaatt tggtccactg atattttaaa ggaccagaaa     1620

gaacccaaaa ataagacctt tctaagatgc gaggccaaga attattctgg acgtttcacc     1680

tgctggtggc tgacgacaat cagtactgat ttgacattca gtgtcaaaag cagcagaggc     1740

tcttctgacc cccaaggggt gacgtgcgga gctgctacac tctctgcaga gagagtcaga     1800

ggggacaaca aggagtatga gtactcagtg gagtgccagg aggacagtgc ctgcccagct     1860

gctgaggaga gtctgcccat tgaggtcatg gtggatgccg ttcacaagct caagtatgaa     1920

aactacacca gcagcttctt catcagggac atcatcaaac ctgacccacc caagaacttg     1980

cagctgaagc cattaaagaa ttctcggcag gtggaggtca gctgggagta ccctgacacc     2040

tggagtactc cacattccta cttctccctg acattctgcg ttcaggtcca gggcaagagc     2100

aagagagaaa agaaagatag agtcttcacg gacaagacct cagccacggt catctgccgc     2160

aaaaatgcca gcattagcgt gcgggcccag gaccgctact atagctcatc ttggagcgaa     2220

tgggcatctg tgccctgcag tggaggcggt ggaagtggcg gtggaggctc tggaggtggc     2280

ggaagcaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa     2340

atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg     2400

caggacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag     2460

cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag     2520

atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag     2580

accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg     2640

atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc     2700

ctgccacccc catggagtcc ccggcccctg gaggccacag ccccgacagc cccgcagccc     2760

cctctgctcc tcctactgct gctgcccgtg ggcctcctgc tgctggccgc tgcctggtgc     2820

ctgcactggc agaggacgcg gcggaggaca ccccgccctg gggagcaggt gccccccgtc     2880

cccagtcccc aggacctgct gcttgtggag cactga                               2916


<210>  55
<211>  2973
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL7IL12bFLT3Lĺ

<400>  55
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg       60

catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc      120

ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc      180

gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg      240

gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct      300

gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta      360

ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact      420

aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt      480

atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg      540

atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg      600

atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg      660

gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca      720

gtgactattg atagagtgat gagctatctg aatgcttccg gtggaggagg ttctggaggc      780

ggtggaagtg gtggcggagg tagcgattgt gatattgaag gtaaagatgg caaacaatat      840

gagagtgttc taatggtcag catcgatcaa ttattggaca gcatgaaaga aattggtagc      900

aattgcctga ataatgaatt taactttttt aaaagacata tctgtgatgc taataaggaa      960

ggtatgtttt tattccgtgc tgctcgcaag ttgaggcaat ttcttaaaat gaatagcact     1020

ggtgattttg atctccactt attaaaagtt tcagaaggca caacaatact gttgaactgc     1080

actggccagg ttaaaggaag aaaaccagct gccctgggtg aagcccaacc aacaaagagt     1140

ttggaagaaa ataaatcttt aaaggaacag aaaaaactga atgacttgtg tttcctaaag     1200

agactattac aagagataaa aacttgttgg aataaaattt tgatgggcac taaagaacac     1260

gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccctatgtgt     1320

caccagcagt tggtcatctc ttggttttcc ctggtttttc tggcatctcc cctcgtggcc     1380

atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct     1440

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg     1500

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt     1560

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg     1620

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa     1680

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc     1740

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct     1800

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg     1860

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct     1920

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac     1980

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag     2040

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg     2100

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag     2160

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa     2220

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg     2280

gcatctgtgc cctgcagtgg aggcggtgga agtggcggtg gaggctctgg aggtggcgga     2340

agcacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc     2400

cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag     2460

gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg     2520

ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata     2580

cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc     2640

aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc     2700

actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg     2760

ccacccccat ggagtccccg gcccctggag gccacagccc cgacagcccc gcagccccct     2820

ctgctcctcc tactgctgct gcccgtgggc ctcctgctgc tggccgctgc ctggtgcctg     2880

cactggcaga ggacgcggcg gaggacaccc cgccctgggg agcaggtgcc ccccgtcccc     2940

agtccccagg acctgctgct tgtggagcac tga                                  2973


<210>  56
<211>  2916
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL15IL12bFLT3Lĺ

<400>  56
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg       60

catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc      120

ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc      180

gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg      240

gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct      300

gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta      360

ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact      420

aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt      480

atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg      540

atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg      600

atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg      660

gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca      720

gtgactattg atagagtgat gagctatctg aatgcttccg gtggaggagg ttctggaggc      780

ggtggaagtg gtggcggagg tagcggcatt catgtcttca ttttgggctg tttcagtgca      840

gggcttccta aaacagaagc caactgggtg aatgtaataa gtgatttgaa aaaaattgaa      900

gatcttattc aatctatgca tattgatgct actttatata cggaaagtga tgttcacccc      960

agttgcaaag taacagcaat gaagtgcttt ctcttggagt tacaagttat ttcacttgag     1020

tccggagatg caagtattca tgatacagta gaaaatctga tcatcctagc aaacaacagt     1080

ttgtcttcta atgggaatgt aacagaatct ggatgcaaag aatgtgagga actggaggaa     1140

aaaaatatta aagaattttt gcagagtttt gtacatattg tccaaatgtt catcaacact     1200

tctgagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc cggccctatg     1260

tgtcaccagc agttggtcat ctcttggttt tccctggttt ttctggcatc tcccctcgtg     1320

gccatatggg aactgaagaa agatgtttat gtcgtagaat tggattggta tccggatgcc     1380

cctggagaaa tggtggtcct cacctgtgac acccctgaag aagatggtat cacctggacc     1440

ttggaccaga gcagtgaggt cttaggctct ggcaaaaccc tgaccatcca agtcaaagag     1500

tttggagatg ctggccagta cacctgtcac aaaggaggcg aggttctaag ccattcgctc     1560

ctgctgcttc acaaaaagga agatggaatt tggtccactg atattttaaa ggaccagaaa     1620

gaacccaaaa ataagacctt tctaagatgc gaggccaaga attattctgg acgtttcacc     1680

tgctggtggc tgacgacaat cagtactgat ttgacattca gtgtcaaaag cagcagaggc     1740

tcttctgacc cccaaggggt gacgtgcgga gctgctacac tctctgcaga gagagtcaga     1800

ggggacaaca aggagtatga gtactcagtg gagtgccagg aggacagtgc ctgcccagct     1860

gctgaggaga gtctgcccat tgaggtcatg gtggatgccg ttcacaagct caagtatgaa     1920

aactacacca gcagcttctt catcagggac atcatcaaac ctgacccacc caagaacttg     1980

cagctgaagc cattaaagaa ttctcggcag gtggaggtca gctgggagta ccctgacacc     2040

tggagtactc cacattccta cttctccctg acattctgcg ttcaggtcca gggcaagagc     2100

aagagagaaa agaaagatag agtcttcacg gacaagacct cagccacggt catctgccgc     2160

aaaaatgcca gcattagcgt gcgggcccag gaccgctact atagctcatc ttggagcgaa     2220

tgggcatctg tgccctgcag tggaggcggt ggaagtggcg gtggaggctc tggaggtggc     2280

ggaagcaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa     2340

atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg     2400

caggacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag     2460

cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag     2520

atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag     2580

accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg     2640

atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc     2700

ctgccacccc catggagtcc ccggcccctg gaggccacag ccccgacagc cccgcagccc     2760

cctctgctcc tcctactgct gctgcccgtg ggcctcctgc tgctggccgc tgcctggtgc     2820

ctgcactggc agaggacgcg gcggaggaca ccccgccctg gggagcaggt gccccccgtc     2880

cccagtcccc aggacctgct gcttgtggag cactga                               2916


<210>  57
<211>  2916
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12aIL21IL12bFLT3Lĺ

<400>  57
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg       60

catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc      120

ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc      180

gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg      240

gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct      300

gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta      360

ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact      420

aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt      480

atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg      540

atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg      600

atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg      660

gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca      720

gtgactattg atagagtgat gagctatctg aatgcttccg gtggaggagg ttctggaggc      780

ggtggaagtg gtggcggagg tagccaaggt caagatcgcc acatgattag aatgcgtcaa      840

cttatagata ttgttgatca gctgaaaaat tatgtgaatg acttggtccc tgaatttctg      900

ccagctccag aagatgtaga gacaaactgt gagtggtcag ctttttcctg ctttcagaag      960

gcccaactaa agtcagcaaa tacaggaaac aatgaaagga taatcaatgt atcaattaaa     1020

aagctgaaga ggaaaccacc ttccacaaat gcagggagaa gacagaaaca cagactaaca     1080

tgcccttcat gtgattctta tgagaaaaaa ccacccaaag aattcctaga aagattcaaa     1140

tcacttctcc aaaagatgat tcatcagcat ctgtcctcta gaacacacgg aagtgaagat     1200

tccgagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc cggccctatg     1260

tgtcaccagc agttggtcat ctcttggttt tccctggttt ttctggcatc tcccctcgtg     1320

gccatatggg aactgaagaa agatgtttat gtcgtagaat tggattggta tccggatgcc     1380

cctggagaaa tggtggtcct cacctgtgac acccctgaag aagatggtat cacctggacc     1440

ttggaccaga gcagtgaggt cttaggctct ggcaaaaccc tgaccatcca agtcaaagag     1500

tttggagatg ctggccagta cacctgtcac aaaggaggcg aggttctaag ccattcgctc     1560

ctgctgcttc acaaaaagga agatggaatt tggtccactg atattttaaa ggaccagaaa     1620

gaacccaaaa ataagacctt tctaagatgc gaggccaaga attattctgg acgtttcacc     1680

tgctggtggc tgacgacaat cagtactgat ttgacattca gtgtcaaaag cagcagaggc     1740

tcttctgacc cccaaggggt gacgtgcgga gctgctacac tctctgcaga gagagtcaga     1800

ggggacaaca aggagtatga gtactcagtg gagtgccagg aggacagtgc ctgcccagct     1860

gctgaggaga gtctgcccat tgaggtcatg gtggatgccg ttcacaagct caagtatgaa     1920

aactacacca gcagcttctt catcagggac atcatcaaac ctgacccacc caagaacttg     1980

cagctgaagc cattaaagaa ttctcggcag gtggaggtca gctgggagta ccctgacacc     2040

tggagtactc cacattccta cttctccctg acattctgcg ttcaggtcca gggcaagagc     2100

aagagagaaa agaaagatag agtcttcacg gacaagacct cagccacggt catctgccgc     2160

aaaaatgcca gcattagcgt gcgggcccag gaccgctact atagctcatc ttggagcgaa     2220

tgggcatctg tgccctgcag tggaggcggt ggaagtggcg gtggaggctc tggaggtggc     2280

ggaagcaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa     2340

atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg     2400

caggacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag     2460

cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag     2520

atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag     2580

accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg     2640

atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc     2700

ctgccacccc catggagtcc ccggcccctg gaggccacag ccccgacagc cccgcagccc     2760

cctctgctcc tcctactgct gctgcccgtg ggcctcctgc tgctggccgc tgcctggtgc     2820

ctgcactggc agaggacgcg gcggaggaca ccccgccctg gggagcaggt gccccccgtc     2880

cccagtcccc aggacctgct gcttgtggag cactga                               2916


<210>  58
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  2Aиİ

<400>  58

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  59
<211>  54
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  2Aиĵĺ

<400>  59
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccct             54


<210>  60
<211>  357
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12a-mIL2һ

<400>  60

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
    210                 215                 220                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
225                 230                 235                 240 


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
                245                 250                 255     


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
            260                 265                 270         


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
        275                 280                 285             


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
    290                 295                 300                 


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
305                 310                 315                 320 


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
                325                 330                 335     


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
            340                 345                 350         


Ser Thr Ser Pro Gln 
        355         


<210>  61
<211>  357
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL2-mIL12aһ

<400>  61

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
        35                  40                  45              


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    50                  55                  60                  


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
65                  70                  75                  80  


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu 
                165                 170                 175     


Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr 
            180                 185                 190         


Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp 
        195                 200                 205             


His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu 
    210                 215                 220                 


Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr 
225                 230                 235                 240 


Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu 
                245                 250                 255     


Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            260                 265                 270         


Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His 
        275                 280                 285             


Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu 
    290                 295                 300                 


Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro 
305                 310                 315                 320 


Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu 
                325                 330                 335     


Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly 
            340                 345                 350         


Tyr Leu Ser Ser Ala 
        355         


<210>  62
<211>  332
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12a-mGMCSFһ

<400>  62

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val 
    210                 215                 220                 


Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr 
225                 230                 235                 240 


Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys 
                245                 250                 255     


Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg 
            260                 265                 270         


Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr 
        275                 280                 285             


Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln 
    290                 295                 300                 


Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr 
305                 310                 315                 320 


Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys 
                325                 330         


<210>  63
<211>  337
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12a-mIL7һ

<400>  63

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Glu Cys His Ile Lys Asp Lys Glu Gly Lys Ala Tyr Glu Ser Val Leu 
    210                 215                 220                 


Met Ile Ser Ile Asp Glu Leu Asp Lys Met Thr Gly Thr Asp Ser Asn 
225                 230                 235                 240 


Cys Pro Asn Asn Glu Pro Asn Phe Phe Arg Lys His Val Cys Asp Asp 
                245                 250                 255     


Thr Lys Glu Ala Ala Phe Leu Asn Arg Ala Ala Arg Lys Leu Lys Gln 
            260                 265                 270         


Phe Leu Lys Met Asn Ile Ser Glu Glu Phe Asn Val His Leu Leu Thr 
        275                 280                 285             


Val Ser Gln Gly Thr Gln Thr Leu Val Asn Cys Thr Ser Lys Glu Glu 
    290                 295                 300                 


Lys Asn Val Lys Glu Gln Lys Lys Asn Asp Ala Cys Phe Leu Lys Arg 
305                 310                 315                 320 


Leu Leu Arg Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Lys Gly Ser 
                325                 330                 335     


Ile 
    


<210>  64
<211>  341
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12a-mIL15һ

<400>  64

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Ile His Val Phe Ile Leu Gly Cys Val Ser Val Gly Leu Pro Lys 
    210                 215                 220                 


Thr Glu Ala Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu 
225                 230                 235                 240 


Ser Leu Ile Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser 
                245                 250                 255     


Asp Phe His Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu 
            260                 265                 270         


Glu Leu Gln Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu 
        275                 280                 285             


Thr Val Arg Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn 
    290                 295                 300                 


Lys Asn Val Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
305                 310                 315                 320 


Lys Thr Phe Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met 
                325                 330                 335     


Phe Ile Asn Thr Ser 
            340     


<210>  65
<211>  337
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12a-mIL21һ

<400>  65

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu Arg 
    210                 215                 220                 


His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp Leu 
225                 230                 235                 240 


Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys Glu 
                245                 250                 255     


His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser Asn 
            260                 265                 270         


Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu Arg 
        275                 280                 285             


Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile Ala 
    290                 295                 300                 


Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu Phe 
305                 310                 315                 320 


Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His Leu 
                325                 330                 335     


Ser 
    


<210>  66
<211>  452
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12b-mGMCSFڶ

<400>  66

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Arg Ser Pro Ile Thr 
                325                 330                 335     


Val Thr Arg Pro Trp Lys His Val Glu Ala Ile Lys Glu Ala Leu Asn 
            340                 345                 350         


Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu Glu Val Glu Val Val 
        355                 360                 365             


Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys Val Gln Thr Arg Leu 
    370                 375                 380                 


Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe Thr Lys Leu Lys Gly 
385                 390                 395                 400 


Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr 
                405                 410                 415     


Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr Tyr Ala Asp Phe Ile 
            420                 425                 430         


Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro Phe Glu Cys Lys Lys 
        435                 440                 445             


Pro Gly Gln Lys 
    450         


<210>  67
<211>  452
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mGMCSF-mIL12bڶ

<400>  67

Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val 
1               5                   10                  15      


Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr 
            20                  25                  30          


Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys 
        35                  40                  45              


Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg 
    50                  55                  60                  


Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr 
65                  70                  75                  80  


Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln 
                85                  90                  95      


Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr 
            100                 105                 110         


Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Trp Glu Leu Glu 
    130                 135                 140                 


Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly 
145                 150                 155                 160 


Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr 
                165                 170                 175     


Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu 
            180                 185                 190         


Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His 
        195                 200                 205             


Lys Gly Gly Glu Thr Leu Ser His Ser His Leu Leu Leu His Lys Lys 
    210                 215                 220                 


Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys 
225                 230                 235                 240 


Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys 
                245                 250                 255     


Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser 
            260                 265                 270         


Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser 
        275                 280                 285             


Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr 
    290                 295                 300                 


Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr 
305                 310                 315                 320 


Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu 
                325                 330                 335     


Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro 
            340                 345                 350         


Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val 
        355                 360                 365             


Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser 
    370                 375                 380                 


Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu 
385                 390                 395                 400 


Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr 
                405                 410                 415     


Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln 
            420                 425                 430         


Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys 
        435                 440                 445             


Arg Val Arg Ser 
    450         


<210>  68
<211>  477
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12b-mIL2ڶ

<400>  68

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Ser 
                325                 330                 335     


Ser Ser Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            340                 345                 350         


Gln Gln His Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser 
        355                 360                 365             


Arg Met Glu Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe 
    370                 375                 380                 


Lys Phe Tyr Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys 
385                 390                 395                 400 


Leu Glu Asp Glu Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln 
                405                 410                 415     


Ser Lys Ser Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile 
            420                 425                 430         


Arg Val Thr Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys 
        435                 440                 445             


Gln Phe Asp Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp 
    450                 455                 460                 


Ile Ala Phe Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln 
465                 470                 475         


<210>  69
<211>  534
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mIL12b-mFLT3Lڶ

<400>  69

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Pro Asp Cys Tyr Phe Ser 
                325                 330                 335     


His Ser Pro Ile Ser Ser Asn Phe Lys Val Lys Phe Arg Glu Leu Thr 
            340                 345                 350         


Asp His Leu Leu Lys Asp Tyr Pro Val Thr Val Ala Val Asn Leu Gln 
        355                 360                 365             


Asp Glu Lys His Cys Lys Ala Leu Trp Ser Leu Phe Leu Ala Gln Arg 
    370                 375                 380                 


Trp Ile Glu Gln Leu Lys Thr Val Ala Gly Ser Lys Met Gln Thr Leu 
385                 390                 395                 400 


Leu Glu Asp Val Asn Thr Glu Ile His Phe Val Thr Ser Cys Thr Phe 
                405                 410                 415     


Gln Pro Leu Pro Glu Cys Leu Arg Phe Val Gln Thr Asn Ile Ser His 
            420                 425                 430         


Leu Leu Lys Asp Thr Cys Thr Gln Leu Leu Ala Leu Lys Pro Cys Ile 
        435                 440                 445             


Gly Lys Ala Cys Gln Asn Phe Ser Arg Cys Leu Glu Val Gln Cys Gln 
    450                 455                 460                 


Pro Asp Ser Ser Thr Leu Leu Pro Pro Arg Ser Pro Ile Ala Leu Glu 
465                 470                 475                 480 


Ala Thr Glu Leu Pro Glu Pro Arg Pro Arg Gln Leu Leu Leu Leu Leu 
                485                 490                 495     


Leu Leu Leu Leu Pro Leu Thr Leu Val Leu Leu Ala Ala Ala Trp Gly 
            500                 505                 510         


Leu Arg Trp Gln Arg Ala Arg Arg Arg Gly Glu Leu His Pro Gly Val 
        515                 520                 525             


Pro Leu Pro Ser His Pro 
    530                 


<210>  70
<211>  345
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12a-hIL2һ

<400>  70

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
    210                 215                 220                 


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
225                 230                 235                 240 


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
                245                 250                 255     


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
            260                 265                 270         


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
        275                 280                 285             


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
    290                 295                 300                 


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
305                 310                 315                 320 


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
                325                 330                 335     


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
            340                 345 


<210>  71
<211>  364
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12a-hIL7һ

<400>  71

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr 
    210                 215                 220                 


Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys 
225                 230                 235                 240 


Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg 
                245                 250                 255     


His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala 
            260                 265                 270         


Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp 
        275                 280                 285             


Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys 
    290                 295                 300                 


Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln 
305                 310                 315                 320 


Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys 
                325                 330                 335     


Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr 
            340                 345                 350         


Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 
        355                 360                 


<210>  72
<211>  345
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12a-hIL15һ

<400>  72

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala 
    210                 215                 220                 


Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu 
225                 230                 235                 240 


Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
                245                 250                 255     


Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
            260                 265                 270         


Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
        275                 280                 285             


Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
    290                 295                 300                 


Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
305                 310                 315                 320 


Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
                325                 330                 335     


Ile Val Gln Met Phe Ile Asn Thr Ser 
            340                 345 


<210>  73
<211>  345
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12a-hIL21һ

<400>  73

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln 
    210                 215                 220                 


Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val 
225                 230                 235                 240 


Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp 
                245                 250                 255     


Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr 
            260                 265                 270         


Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg 
        275                 280                 285             


Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr 
    290                 295                 300                 


Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu 
305                 310                 315                 320 


Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser 
                325                 330                 335     


Ser Arg Thr His Gly Ser Glu Asp Ser 
            340                 345 


<210>  74
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12b-hGMCSFڶ

<400>  74

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
                325                 330                 335     


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
            340                 345                 350         


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
        355                 360                 365             


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
    370                 375                 380                 


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
385                 390                 395                 400 


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
                405                 410                 415     


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
            420                 425                 430         


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        435                 440                 445             


<210>  75
<211>  530
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hIL12b-hFLT3Lڶ

<400>  75

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 
                325                 330                 335     


Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 
            340                 345                 350         


Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 
        355                 360                 365             


Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 
    370                 375                 380                 


Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 
385                 390                 395                 400 


His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 
                405                 410                 415     


Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 
            420                 425                 430         


Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 
        435                 440                 445             


Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp 
    450                 455                 460                 


Ser Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Pro 
465                 470                 475                 480 


Leu Leu Leu Leu Leu Leu Leu Pro Val Gly Leu Leu Leu Leu Ala Ala 
                485                 490                 495     


Ala Trp Cys Leu His Trp Gln Arg Thr Arg Arg Arg Thr Pro Arg Pro 
            500                 505                 510         


Gly Glu Gln Val Pro Pro Val Pro Ser Pro Gln Asp Leu Leu Leu Val 
        515                 520                 525             


Glu His 
    530 


