                         SEQUENCE LISTING

<110>  aTyr Pharma, Inc.
       Burkart, Christoph
       Ogilvie, Kathleen M.
       Paz, Suzanne
       Rosengren, Sanna
       Datta, Kaustubh
       Dutta, Samikshan
 
<120>  COMPOSITIONS AND METHODS FOR TREATING NRP2-ASSOCIATED DISEASES

<130>  ATYR-135/04WO 315789-2771

<150>  US 62/703,757
<151>  2018-07-26

<150>  US 62/776,208
<151>  2018-12-06

<150>  US 62/800,035
<151>  2019-02-01

<150>  US 62/849,440
<151>  2019-05-17

<160>  264   

<170>  PatentIn version 3.5

<210>  1
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
            500                 505                 


<210>  2
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg 
            500 


<210>  3
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg 
            500     


<210>  4
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr 
            500         


<210>  5
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly 
            500             


<210>  6
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln 
            500                 


<210>  7
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  8
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg 
1               5                   10                  15      


Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu 
            20                  25                  30          


Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu 
        35                  40                  45              


Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr 
    50                  55                  60                  


Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile Ile 
65                  70                  75                  80  


Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val Phe 
                85                  90                  95      


Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys Leu 
            100                 105                 110         


Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr 
        115                 120                 125             


Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu Thr 
    130                 135                 140                 


Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn Pro 
145                 150                 155                 160 


Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe Asp 
                165                 170                 175     


Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys 
            180                 185                 190         


Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu Val 
        195                 200                 205             


Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly 
    210                 215                 220                 


Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu 
225                 230                 235                 240 


Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys 
                245                 250                 255     


Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln 
            260                 265                 270         


His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu 
        275                 280                 285             


Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu 
    290                 295                 300                 


Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp 
305                 310                 315                 320 


Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu 
                325                 330                 335     


Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly 
            340                 345                 350         


Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met 
        355                 360                 365             


Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly 
    370                 375                 380                 


Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu 
385                 390                 395                 400 


Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln 
                405                 410                 415     


Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp 
            420                 425                 430         


Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu 
        435                 440                 445             


Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile 
    450                 455                 460                 


Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val 
465                 470                 475                 480 


Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu 
                485                 490                 495     


Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505 


<210>  9
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys 
            500                 505         


<210>  10
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile 
            500                 505             


<210>  11
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


<210>  12
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


<210>  13
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val 
65                  70                  75                  


<210>  14
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp 
65                  70                  75              


<210>  15
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe 
65                  70                  75          


<210>  16
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val 
65                  70                  75      


<210>  17
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys 
65                  70                  75  


<210>  18
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu 
65                  70                  


<210>  19
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg 
65                  70              


<210>  20
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val 
65                  70          


<210>  21
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala 
65                  70      


<210>  22
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met 
65                  70  


<210>  23
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln 
65                  


<210>  24
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg 
65              


<210>  25
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro 
65          


<210>  26
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser 
65      


<210>  27
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr 
65  


<210>  28
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


<210>  29
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg 
    50                  55                  60              


<210>  30
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr 
    50                  55                  60          


<210>  31
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly 
    50                  55                  60      


<210>  32
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
    50                  55                  60  


<210>  33
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro 
    50                  55                  


<210>  34
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr 
    50                  55              


<210>  35
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys 
    50                  55          


<210>  36
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu 
    50                  55      


<210>  37
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val 
    50                  55  


<210>  38
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe 
    50                  


<210>  39
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys 
    50              


<210>  40
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln 
    50          


<210>  41
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys 
    50      


<210>  42
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser 
    50  


<210>  43
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu 
    


<210>  44
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


<210>  45
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro 
        35                  40                  45          


<210>  46
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly 
        35                  40                  45      


<210>  47
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu 
        35                  40                  45  


<210>  48
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
        35                  40                  


<210>  49
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala 
        35                  40              


<210>  50
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys 
        35                  40          


<210>  51
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu 
        35                  40      


<210>  52
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys 
        35                  40  


<210>  53
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  53

Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg 
1               5                   10                  15      


Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu 
            20                  25                  30          


Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu 
        35                  40                  45              


Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr 
    50                  55                  60                  


Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  


<210>  54
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  54

Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val 
1               5                   10                  15      


Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu 
            20                  25                  30          


Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser 
        35                  40                  45              


Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser 
    50                  55                  60                  


Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75              


<210>  55
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  55

Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg 
1               5                   10                  15      


Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val 
            20                  25                  30          


Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys 
        35                  40                  45              


Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro 
    50                  55                  60                  


Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75          


<210>  56
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  56

Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly 
1               5                   10                  15      


Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala 
            20                  25                  30          


Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln 
        35                  40                  45              


Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg 
    50                  55                  60                  


Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75      


<210>  57
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  57

Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu 
1               5                   10                  15      


Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys 
            20                  25                  30          


Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys 
        35                  40                  45              


Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln 
    50                  55                  60                  


Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75  


<210>  58
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  58

Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys 
1               5                   10                  15      


Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu 
            20                  25                  30          


Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe 
        35                  40                  45              


Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met 
    50                  55                  60                  


Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  


<210>  59
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  59

Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln 
1               5                   10                  15      


Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu 
            20                  25                  30          


Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val 
        35                  40                  45              


Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala 
    50                  55                  60                  


Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70              


<210>  60
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  60

Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln 
1               5                   10                  15      


Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys 
            20                  25                  30          


Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu 
        35                  40                  45              


Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val 
    50                  55                  60                  


Arg Glu Lys Val Phe Asp Val Ile 
65                  70          


<210>  61
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  61

Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys 
1               5                   10                  15      


Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu 
            20                  25                  30          


Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys 
        35                  40                  45              


Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg 
    50                  55                  60                  


Glu Lys Val Phe Asp Val Ile 
65                  70      


<210>  62
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  62

Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala 
1               5                   10                  15      


Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys 
            20                  25                  30          


Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr 
        35                  40                  45              


Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu 
    50                  55                  60                  


Lys Val Phe Asp Val Ile 
65                  70  


<210>  63
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  63

Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser 
1               5                   10                  15      


Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala 
            20                  25                  30          


Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro 
        35                  40                  45              


Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys 
    50                  55                  60                  


Val Phe Asp Val Ile 
65                  


<210>  64
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  64

Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
1               5                   10                  15      


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            20                  25                  30          


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
        35                  40                  45              


Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val 
    50                  55                  60                  


Phe Asp Val Ile 
65              


<210>  65
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  65

Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu 
1               5                   10                  15      


Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu 
            20                  25                  30          


Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly 
        35                  40                  45              


Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe 
    50                  55                  60                  


Asp Val Ile 
65          


<210>  66
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  66

Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu 
1               5                   10                  15      


Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly 
            20                  25                  30          


Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr 
        35                  40                  45              


Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp 
    50                  55                  60                  


Val Ile 
65      


<210>  67
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  67

Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
1               5                   10                  15      


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
            20                  25                  30          


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
        35                  40                  45              


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60                  


<210>  68
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  68

Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu 
1               5                   10                  15      


Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu 
            20                  25                  30          


Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr 
        35                  40                  45              


Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60              


<210>  69
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  69

Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu 
1               5                   10                  15      


Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser 
            20                  25                  30          


Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser 
        35                  40                  45              


Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60          


<210>  70
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  70

Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val 
1               5                   10                  15      


Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys 
            20                  25                  30          


Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro 
        35                  40                  45              


Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60      


<210>  71
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  71

Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala 
1               5                   10                  15      


Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln 
            20                  25                  30          


Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg 
        35                  40                  45              


Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60  


<210>  72
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  72

Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys 
1               5                   10                  15      


Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys 
            20                  25                  30          


Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln 
        35                  40                  45              


Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  


<210>  73
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  73

Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu 
1               5                   10                  15      


Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe 
            20                  25                  30          


Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met 
        35                  40                  45              


Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55              


<210>  74
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  74

Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu 
1               5                   10                  15      


Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val 
            20                  25                  30          


Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala 
        35                  40                  45              


Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55          


<210>  75
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  75

Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys 
1               5                   10                  15      


Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu 
            20                  25                  30          


Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val 
        35                  40                  45              


Arg Glu Lys Val Phe Asp Val Ile 
    50                  55      


<210>  76
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  76

Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu 
1               5                   10                  15      


Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys 
            20                  25                  30          


Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg 
        35                  40                  45              


Glu Lys Val Phe Asp Val Ile 
    50                  55  


<210>  77
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  77

Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys 
1               5                   10                  15      


Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr 
            20                  25                  30          


Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu 
        35                  40                  45              


Lys Val Phe Asp Val Ile 
    50                  


<210>  78
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  78

Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala 
1               5                   10                  15      


Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro 
            20                  25                  30          


Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys 
        35                  40                  45              


Val Phe Asp Val Ile 
    50              


<210>  79
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  79

Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
1               5                   10                  15      


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
            20                  25                  30          


Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val 
        35                  40                  45              


Phe Asp Val Ile 
    50          


<210>  80
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  80

Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu 
1               5                   10                  15      


Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly 
            20                  25                  30          


Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe 
        35                  40                  45              


Asp Val Ile 
    50      


<210>  81
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  81

Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly 
1               5                   10                  15      


Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr 
            20                  25                  30          


Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp 
        35                  40                  45              


Val Ile 
    50  


<210>  82
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  82

Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro 
1               5                   10                  15      


Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg 
            20                  25                  30          


Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val 
        35                  40                  45              


Ile 
    


<210>  83
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  83

Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
1               5                   10                  15      


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
            20                  25                  30          


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  45              


<210>  84
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  84

Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu 
1               5                   10                  15      


Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr 
            20                  25                  30          


Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  45          


<210>  85
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  85

Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser 
1               5                   10                  15      


Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser 
            20                  25                  30          


Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  45      


<210>  86
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  86

Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys 
1               5                   10                  15      


Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro 
            20                  25                  30          


Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  45  


<210>  87
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  87

Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln 
1               5                   10                  15      


Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg 
            20                  25                  30          


Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  


<210>  88
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  88

Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys 
1               5                   10                  15      


Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln 
            20                  25                  30          


Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40              


<210>  89
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  89

Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe 
1               5                   10                  15      


Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met 
            20                  25                  30          


Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40          


<210>  90
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  90

Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val 
1               5                   10                  15      


Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala 
            20                  25                  30          


Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40      


<210>  91
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  91

Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu 
1               5                   10                  15      


Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val 
            20                  25                  30          


Arg Glu Lys Val Phe Asp Val Ile 
        35                  40  


<210>  92
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met 
    130                 135                 140     


<210>  93
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu 
                405             


<210>  94
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu 
    


<210>  95
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
    50                  55                  60  


<210>  96
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Gly Tyr Pro Trp Trp Asn Ser Cys Ser Arg Ile Leu 
                245                 250                 255     


Asn Tyr Pro Lys Thr Ser Arg Pro Trp Arg Ala Trp Glu Thr 
            260                 265                 270 


<210>  97
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  97

Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu 
1               5                   10                  15      


Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile 
            20                  25                  30          


Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu 
        35                  40                  45              


Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu 
    50                  55                  60                  


Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg 
65                  70                  75                  80  


Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg 
                85                  90                  95      


Arg Thr Gly Gln Pro Leu Cys Ile Cys 
            100                 105 


<210>  98
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Asp Phe Asp Ile 
    50                  55                  60                  


Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile 
65                  70                  75                  80  


Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu Val Lys 
                85                  90                  95      


Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val 
            100                 105                 110         


Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp 
        115                 120                 125             


Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly 
    130                 135                 140                 


Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His 
145                 150                 155                 160 


Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser 
                165                 170                 175     


Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe 
            180                 185                 190         


Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu 
        195                 200                 205             


Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala 
    210                 215                 220                 


Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val 
225                 230                 235                 240 


Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe 
                245                 250                 255     


Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val 
            260                 265                 270         


Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu 
        275                 280                 285             


Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys 
    290                 295                 300                 


Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala 
305                 310                 315                 320 


Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn 
                325                 330                 335     


Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile 
            340                 345                 350         


Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr 
        355                 360                 365             


Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile 
    370                 375                 380                 


Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
385                 390                 395 


<210>  99
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Val Asn Asp Arg 
    50                  55                  60                  


Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys 
65                  70                  75                  80  


Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp 
                85                  90                  95      


Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu 
            100                 105                 110         


Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser 
        115                 120                 125             


Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln 
    130                 135                 140                 


Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr 
145                 150                 155                 160 


Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg 
                165                 170                 175     


Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln 
            180                 185                 190         


Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala 
        195                 200                 205             


Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly 
    210                 215                 220                 


Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe 
225                 230                 235                 240 


Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr 
                245                 250                 255     


Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu 
            260                 265                 270         


Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala 
        275                 280                 285             


Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr 
    290                 295                 300                 


Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu 
305                 310                 315                 320 


Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu 
                325                 330                 335     


Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr 
            340                 345                 350         


Gly Gln Pro Leu Cys Ile Cys 
        355                 


<210>  100
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala 
            100                 105                 110         


Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val 
        115                 120                 125             


Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val 
    130                 135                 140                 


Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr 
145                 150                 155                 160 


Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp 
                165                 170                 175     


Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu 
            180                 185                 190         


Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile 
        195                 200                 205             


Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val 
    210                 215                 220                 


Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu 
225                 230                 235                 240 


Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu 
                245                 250                 255     


Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu 
            260                 265                 270         


Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu 
        275                 280                 285             


Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala 
    290                 295                 300                 


Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu 
305                 310                 315                 320 


Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro 
                325                 330                 335     


Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu 
            340                 345                 350         


Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu 
        355                 360                 365             


Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu 
    370                 375                 380                 


Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
385                 390                 395                 


<210>  101
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Val Asn 
                165                 170                 175     


Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp 
            180                 185                 190         


Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val 
        195                 200                 205             


Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala 
    210                 215                 220                 


Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly 
225                 230                 235                 240 


Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn 
                245                 250                 255     


Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr 
            260                 265                 270         


Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu 
        275                 280                 285             


Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu 
    290                 295                 300                 


Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser 
305                 310                 315                 320 


Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro 
                325                 330                 335     


Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg 
            340                 345                 350         


Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile 
        355                 360                 365             


Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu 
    370                 375                 380                 


Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile 
385                 390                 395                 400 


Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu 
                405                 410                 415     


Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu 
            420                 425                 430         


Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg 
        435                 440                 445             


Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg 
    450                 455                 460                 


Arg Thr Gly Gln Pro Leu Cys Ile Cys 
465                 470             


<210>  102
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Glu Thr Leu Met 
    50                  55                  60                  


Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln 
65                  70                  75                  80  


Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala 
                85                  90                  95      


Arg Tyr Leu Ala Met Asn Lys Leu Thr Asn Ile Lys Arg Tyr His Ile 
            100                 105                 110         


Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr 
        115                 120                 125             


Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro 
    130                 135                 140                 


Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser 
145                 150                 155                 160 


Ser Leu Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile 
                165                 170                 175     


Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg 
            180                 185                 190         


Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu 
        195                 200                 205             


Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala 
    210                 215                 220                 


Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val 
225                 230                 235                 240 


Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu 
                245                 250                 255     


Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe 
            260                 265                 270         


Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu 
        275                 280                 285             


Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro 
    290                 295                 300                 


Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly 
305                 310                 315                 320 


Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys 
                325                 330                 335     


Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile 
            340                 345                 350         


Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu 
        355                 360                 365             


Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg 
    370                 375                 380                 


Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu 
385                 390                 395                 400 


Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu 
                405                 410                 415     


Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys 
            420                 425                 430         


Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp 
        435                 440                 445             


Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln 
    450                 455                 460                 


Pro Leu Cys Ile Cys 
465                 


<210>  103
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile 
            100                 105                 110         


Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu 
        115                 120                 125             


Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp 
    130                 135                 140                 


Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile 
145                 150                 155                 160 


Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys 
                165                 170                 175     


Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg 
            180                 185                 190         


Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln 
        195                 200                 205             


Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly 
    210                 215                 220                 


Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile 
225                 230                 235                 240 


Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr 
                245                 250                 255     


Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln 
            260                 265                 270         


Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg 
        275                 280                 285             


Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro 
    290                 295                 300                 


Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu 
305                 310                 315                 320 


Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln 
                325                 330                 335     


Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys 
            340                 345                 350         


Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr 
        355                 360                 365             


Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala 
    370                 375                 380                 


Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly 
385                 390                 395                 400 


Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg 
                405                 410                 415     


Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            420                 425                 430         


Cys Ile Cys 
        435 


<210>  104
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Ala Leu Glu Glu 
    50                  55                  60                  


Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys 
65                  70                  75                  80  


Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala 
                85                  90                  95      


Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn 
            100                 105                 110         


Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile 
        115                 120                 125             


Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr 
    130                 135                 140                 


Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile 
145                 150                 155                 160 


Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
                165                 170     


<210>  105
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln 
            100                 105                 110         


Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys 
        115                 120                 125             


Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr 
    130                 135                 140                 


Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala 
145                 150                 155                 160 


Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly 
                165                 170                 175     


Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg 
            180                 185                 190         


Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
        195                 200                 205             


Cys Ile Cys 
    210     


<210>  106
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
1               5                   10                  15      


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
            20                  25                  30          


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
        35                  40                  45              


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
    50                  55                  60                  


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
65                  70                  75                  80  


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
                85                  90                  95      


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
            100                 105                 110         


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
        115                 120                 125             


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
    130                 135                 140     


<210>  107
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  107

Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp 
1               5                   10                  15      


Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala 
            20                  25                  30          


Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val 
        35                  40                  45              


Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val 
    50                  55                  60                  


Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr 
65                  70                  75                  80  


Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp 
                85                  90                  95      


Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu 
            100                 105                 110         


Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile 
        115                 120                 125             


Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly 
    130                 135                 140             


<210>  108
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Val Ala Glu Ala Val Leu Thr Ser Gln Leu Lys Ala 
        35                  40                  45              


His Gln Glu Lys Pro Asn Phe Ile Ile Lys Thr Pro Lys Gly Thr Arg 
    50                  55                  60                  


Asp Leu Ser Pro Gln His Met Val Val Arg Glu Lys Ile Leu Asp Leu 
65                  70                  75                  80  


Val Ile Ser Cys Phe Lys Arg His Gly Ala Lys Gly Met Asp Thr Pro 
                85                  90                  95      


Ala Phe Glu Leu Lys Glu Thr Leu Thr Glu Lys Tyr Gly Glu Asp Ser 
            100                 105                 110         


Gly Leu Met Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu 
        115                 120                 125             


Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys 
    130                 135                 140                 


Val Lys Lys Met Lys Arg Tyr His Val Gly Lys Val Trp Arg Arg Glu 
145                 150                 155                 160 


Ser Pro Thr Ile Val Gln Gly Arg Tyr Arg Glu Phe Cys Gln Cys Asp 
                165                 170                 175     


Phe Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys 
            180                 185                 190         


Leu Lys Ile Met Cys Glu Ile Leu Ser Gly Leu Gln Leu Gly Asp Phe 
        195                 200                 205             


Leu Ile Lys Val Asn Asp Arg Arg Ile Val Asp Gly Met Phe Ala Val 
    210                 215                 220                 


Cys Gly Val Pro Glu Ser Lys Phe Arg Ala Ile Cys Ser Ser Ile Asp 
225                 230                 235                 240 


Lys Leu Asp Lys Met Ala Trp Lys Asp Val Arg His Glu Met Val Val 
                245                 250                 255     


Lys Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val 
            260                 265                 270         


Gln Cys His Gly Gly Val Ser Leu Val Glu Gln Met Phe Gln Asp Pro 
        275                 280                 285             


Arg Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys 
    290                 295                 300                 


Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser 
305                 310                 315                 320 


Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile 
                325                 330                 335     


Tyr Glu Ala Val Leu Leu Gln Thr Pro Thr Gln Ala Gly Glu Glu Pro 
            340                 345                 350         


Leu Asn Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val 
        355                 360                 365             


Gly Met Phe Asp Pro Lys Gly His Lys Val Pro Cys Val Gly Leu Ser 
    370                 375                 380                 


Ile Gly Val Glu Arg Ile Phe Tyr Ile Val Glu Gln Arg Met Lys Thr 
385                 390                 395                 400 


Lys Gly Glu Lys Val Arg Thr Thr Glu Thr Gln Val Phe Val Ala Thr 
                405                 410                 415     


Pro Gln Lys Asn Phe Leu Gln Glu Arg Leu Lys Leu Ile Ala Glu Leu 
            420                 425                 430         


Trp Asp Ser Gly Ile Lys Ala Glu Met Leu Tyr Lys Asn Asn Pro Lys 
        435                 440                 445             


Leu Leu Thr Gln Leu His Tyr Cys Glu Ser Thr Gly Ile Pro Leu Val 
    450                 455                 460                 


Val Ile Ile Gly Glu Gln Glu Leu Lys Glu Gly Val Ile Lys Ile Arg 
465                 470                 475                 480 


Ser Val Ala Ser Arg Glu Glu Val Ala Ile Lys Arg Glu Asn Phe Val 
                485                 490                 495     


Ala Glu Ile Gln Lys Arg Leu Ser Glu Ser 
            500                 505     


<210>  109
<211>  509
<212>  PRT
<213>  Mus musculus

<400>  109

Met Ala Asp Arg Ala Ala Leu Glu Glu Leu Val Arg Leu Gln Gly Ala 
1               5                   10                  15      


His Val Arg Gly Leu Lys Glu Gln Lys Ala Ser Ala Glu Gln Ile Glu 
            20                  25                  30          


Glu Glu Val Thr Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Gln Asp 
        35                  40                  45              


Glu Gly Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asn Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Val Cys 
    210                 215                 220                 


Gly Val Pro Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Val Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Ile Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Met Pro Thr Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Ile Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Ser 
385                 390                 395                 400 


Glu Glu Lys Val Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Trp Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Arg Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Ala Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Arg Arg Arg Thr Asn Gln Pro Leu Ser Thr Cys 
            500                 505                 


<210>  110
<211>  509
<212>  PRT
<213>  Canis lupus familiaris

<400>  110

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Arg Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Gln Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Gly Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Ser Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Glu Ile Met Cys Glu Ile Leu Arg Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Pro Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp His Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Ile Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Glu 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Val Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Thr 
385                 390                 395                 400 


Glu Glu Lys Val Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asn Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Ala Ser Arg Glu Glu Val Asp Val Pro Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Ser Gln Pro Phe Cys Ile Cys 
            500                 505                 


<210>  111
<211>  509
<212>  PRT
<213>  Bos taurus

<400>  111

Met Ala Asp Arg Ala Ala Leu Glu Asp Leu Val Arg Val Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Gln Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Gly Lys Pro Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Ser Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Gln Phe Asp Pro Met Leu Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Pro Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Pro Pro Ala Arg Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Val Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Ile Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Thr Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Ala Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Ser Gln Pro Leu Cys Ile Cys 
            500                 505                 


<210>  112
<211>  508
<212>  PRT
<213>  Rattus norvegicus

<400>  112

Met Ala Asp Arg Ala Ala Leu Glu Glu Leu Val Arg Leu Gln Gly Ala 
1               5                   10                  15      


His Val Arg Gly Leu Lys Glu Gln Lys Ala Ser Ala Glu Gln Ile Glu 
            20                  25                  30          


Glu Glu Val Thr Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly His Asp 
        35                  40                  45              


Glu Gly Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asn Phe Gln 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Val Cys 
    210                 215                 220                 


Gly Val Pro Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Val Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Met Pro Thr Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Ile Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Lys Leu Glu Ala Ser 
385                 390                 395                 400 


Glu Glu Lys Val Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Ile Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Arg Arg Arg Thr Ser Gln Pro Leu Ser Met 
            500                 505             


<210>  113
<211>  500
<212>  PRT
<213>  Gallus gallus

<400>  113

Met Ala Asp Glu Ala Ala Val Arg Gln Gln Ala Glu Val Val Arg Arg 
1               5                   10                  15      


Leu Lys Gln Asp Lys Ala Glu Pro Asp Glu Ile Ala Lys Glu Val Ala 
            20                  25                  30          


Lys Leu Leu Glu Met Lys Ala His Leu Gly Gly Asp Glu Gly Lys His 
        35                  40                  45              


Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Gly Pro Lys 
    50                  55                  60                  


Gln Met Ala Ile Arg Glu Arg Val Phe Ser Ala Ile Ile Ala Cys Phe 
65                  70                  75                  80  


Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val Phe Glu Leu Lys 
                85                  90                  95      


Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp 
            100                 105                 110         


Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr 
        115                 120                 125             


Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Ile Thr Asn Ile Lys 
    130                 135                 140                 


Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr 
145                 150                 155                 160 


Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly 
                165                 170                 175     


Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Val Gln 
            180                 185                 190         


Glu Ile Leu Ser Asp Leu Gln Leu Gly Asp Phe Leu Ile Lys Val Asn 
        195                 200                 205             


Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Val Cys Gly Val Pro Asp 
    210                 215                 220                 


Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Met 
225                 230                 235                 240 


Pro Trp Glu Glu Val Arg Asn Glu Met Val Gly Glu Lys Gly Leu Ser 
                245                 250                 255     


Pro Glu Ala Ala Asp Arg Ile Gly Glu Tyr Val Gln Leu His Gly Gly 
            260                 265                 270         


Met Asp Leu Ile Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn 
        275                 280                 285             


Lys Leu Val Lys Glu Gly Leu Gly Asp Met Lys Leu Leu Phe Glu Tyr 
    290                 295                 300                 


Leu Thr Leu Phe Gly Ile Thr Gly Lys Ile Ser Phe Asp Leu Ser Leu 
305                 310                 315                 320 


Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu 
                325                 330                 335     


Leu Gln Gln Asn Asp His Gly Glu Glu Ser Val Ser Val Gly Ser Val 
            340                 345                 350         


Ala Gly Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys 
        355                 360                 365             


Gly Arg Lys Val Pro Cys Val Gly Ile Ser Ile Gly Ile Glu Arg Ile 
    370                 375                 380                 


Phe Ser Ile Leu Glu Gln Arg Val Glu Ala Ser Glu Glu Lys Ile Arg 
385                 390                 395                 400 


Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu 
                405                 410                 415     


Glu Glu Arg Leu Lys Leu Ile Ser Glu Leu Trp Asp Ala Gly Ile Lys 
            420                 425                 430         


Ala Glu Val Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln 
        435                 440                 445             


Tyr Cys Glu Asp Thr Gly Ile Pro Leu Val Ala Ile Val Gly Glu Gln 
    450                 455                 460                 


Glu Leu Lys Asp Gly Val Val Lys Leu Arg Val Val Ala Thr Gly Glu 
465                 470                 475                 480 


Glu Val Asn Ile Arg Arg Glu Ser Leu Val Glu Glu Ile Arg Arg Arg 
                485                 490                 495     


Thr Asn Gln Leu 
            500 


<210>  114
<211>  437
<212>  PRT
<213>  Danio rerio

<400>  114

Met Ala Ala Leu Gly Leu Val Ser Met Arg Leu Cys Ala Gly Leu Met 
1               5                   10                  15      


Gly Arg Arg Ser Ala Val Arg Leu His Ser Leu Arg Val Cys Ser Gly 
            20                  25                  30          


Met Thr Ile Ser Gln Ile Asp Glu Glu Val Ala Arg Leu Leu Gln Leu 
        35                  40                  45              


Lys Ala Gln Leu Gly Gly Asp Glu Gly Lys His Val Phe Val Leu Lys 
    50                  55                  60                  


Thr Ala Lys Gly Thr Arg Asp Tyr Asn Pro Lys Gln Met Ala Ile Arg 
65                  70                  75                  80  


Glu Lys Val Phe Asn Ile Ile Ile Asn Cys Phe Lys Arg His Gly Ala 
                85                  90                  95      


Glu Thr Ile Asp Ser Pro Val Phe Glu Leu Lys Glu Thr Leu Thr Gly 
            100                 105                 110         


Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln Gly 
        115                 120                 125             


Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg 
    130                 135                 140                 


Tyr Leu Ala Met Asn Lys Ile Thr Asn Ile Lys Arg Tyr His Ile Ala 
145                 150                 155                 160 


Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr Arg 
                165                 170                 175     


Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Gln Tyr Asp Ala Met 
            180                 185                 190         


Ile Pro Asp Ala Glu Cys Leu Lys Leu Val Tyr Glu Ile Leu Ser Glu 
        195                 200                 205             


Leu Asp Leu Gly Asp Phe Arg Ile Lys Val Asn Asp Arg Arg Ile Leu 
    210                 215                 220                 


Asp Gly Met Phe Ala Ile Cys Gly Val Pro Asp Glu Lys Phe Arg Thr 
225                 230                 235                 240 


Ile Cys Ser Thr Val Asp Lys Leu Asp Lys Leu Ala Trp Glu Glu Val 
                245                 250                 255     


Lys Lys Glu Met Val Asn Glu Lys Gly Leu Ser Glu Glu Val Ala Asp 
            260                 265                 270         


Arg Ile Arg Asp Tyr Val Ser Met Gln Gly Gly Lys Asp Leu Ala Glu 
        275                 280                 285             


Arg Leu Leu Gln Asp Pro Lys Leu Ser Gln Ser Lys Gln Ala Cys Ala 
    290                 295                 300                 


Gly Ile Thr Asp Met Lys Leu Leu Phe Ser Tyr Leu Glu Leu Phe Gln 
305                 310                 315                 320 


Ile Thr Asp Lys Val Val Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp 
                325                 330                 335     


Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Ile Leu Thr Gln Ala Asn Pro 
            340                 345                 350         


Ala Pro Ala Ser Thr Pro Ala Glu Gln Asn Gly Ala Glu Asp Ala Gly 
        355                 360                 365             


Val Ser Val Gly Ser Val Ala Gly Gly Gly Arg Tyr Asp Gly Leu Val 
    370                 375                 380                 


Gly Met Phe Asp Pro Lys Ala Gly Lys Cys Pro Val Trp Gly Ser Ala 
385                 390                 395                 400 


Leu Ala Leu Arg Gly Ser Ser Pro Ser Trp Ser Arg Arg Gln Ser Cys 
                405                 410                 415     


Leu Gln Arg Arg Cys Ala Pro Leu Lys Leu Lys Cys Leu Trp Leu Gln 
            420                 425                 430         


His Arg Arg Thr Phe 
        435         


<210>  115
<211>  435
<212>  PRT
<213>  Macaca fascicularis

<400>  115

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Gln Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Gly Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile 
            100                 105                 110         


Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu 
        115                 120                 125             


Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp 
    130                 135                 140                 


Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile 
145                 150                 155                 160 


Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys 
                165                 170                 175     


Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg 
            180                 185                 190         


Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln 
        195                 200                 205             


Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly 
    210                 215                 220                 


Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile 
225                 230                 235                 240 


Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr 
                245                 250                 255     


Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln 
            260                 265                 270         


Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg 
        275                 280                 285             


Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro 
    290                 295                 300                 


Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu 
305                 310                 315                 320 


Gln Arg Leu Glu Ala Leu Glu Glu Lys Val Arg Thr Thr Glu Thr Gln 
                325                 330                 335     


Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys 
            340                 345                 350         


Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr 
        355                 360                 365             


Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala 
    370                 375                 380                 


Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly 
385                 390                 395                 400 


Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asn Val Arg 
                405                 410                 415     


Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Leu Leu 
            420                 425                 430         


Arg Ile Cys 
        435 


<210>  116
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus HRS WHEP sequence


<220>
<221>  MOD_RES
<222>  (1)..(50)
<223>  Xaa is any amino acid or absent

<220>
<221>  misc_feature
<222>  (52)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (57)..(58)
<223>  Xaa is any amino acid or absent

<220>
<221>  MOD_RES
<222>  (61)..(62)
<223>  Xaa is any amino acid

<220>
<221>  MOD_RES
<222>  (65)..(65)
<223>  Xaa is any amino acid

<220>
<221>  MOD_RES
<222>  (68)..(69)
<223>  Xaa is any amino acid

<220>
<221>  misc_feature
<222>  (72)..(78)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (79)..(80)
<223>  Xaa is any amino acid or absent

<220>
<221>  MOD_RES
<222>  (82)..(83)
<223>  Xaa is any amino acid

<220>
<221>  MOD_RES
<222>  (86)..(86)
<223>  Xaa is any amino acid

<220>
<221>  MOD_RES
<222>  (89)..(138)
<223>  Xaa is any amino acid or absent

<400>  116

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Gly Xaa Xaa Val Arg 
    50                  55                  60                  


Xaa Leu Lys Xaa Xaa Lys Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Val Xaa Xaa Leu Leu Xaa Leu Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135             


<210>  117
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab:  cysteine modified HRS polypeptide

<400>  117

Met Cys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly 
1               5                   10                  15      


Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile 
            20                  25                  30          


Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro 
        35                  40                  45              


Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
    50                  55                  60      


<210>  118
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab:  cysteine modified HRS polypeptide

<400>  118

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Cys Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
    50                  55                  60  


<210>  119
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab:  cysteine modified HRS polypeptide

<400>  119

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Cys 
    50                  55                  60      


<210>  120
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: modified HRS polypeptide to remove surface exposed 
       cysteines

<400>  120

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Ala Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  121
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: modified HRS polypeptide to remove surface exposed 
       cysteines

<400>  121

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Val Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  122
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: modified HRS polypeptide to remove surface exposed 
       cysteines

<400>  122

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Ala Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  123
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: modified HRS polypeptide to remove surface exposed 
       cysteines

<400>  123

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Ser Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  124
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: modified HRS polypeptide to remove surface exposed 
       cysteines

<400>  124

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Val Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  125
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: modified HRS polypeptide to remove surface exposed 
       cysteines

<400>  125

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Ser 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  126
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: modified HRS polypeptide to remove surface exposed 
       cysteines

<400>  126

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Ser Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  127
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  127

Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro 
1               5                   10                  15      


Ser Pro Ser 
            


<210>  128
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  128

Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
1               5                   10                  15      


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
            20                  25                  30          


Asp Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
        35                  40                  45              


Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val 
    50                  55                  60                  


Ser Ser Val Leu Pro Gly Cys Ala Glu Pro Trp Asn His Gly Lys Thr 
65                  70                  75                  80  


Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys Thr Pro Leu Thr Ala 
                85                  90                  95      


Thr Leu Ser Lys Ser 
            100     


<210>  129
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  129

Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu 
1               5                   10                  15      


Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly 
            20                  25                  30          


Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu 
        35                  40                  45              


Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser 
    50                  55                  60                  


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala 
65                  70                  75                  80  


Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu 
                85                  90                  95      


Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
            100                 105                 110         


Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  130
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  130

Val Pro Pro Pro Pro Pro 
1               5       


<210>  131
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  131

Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
1               5                   10                  15      


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
            20                  25                  30          


Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
        35                  40                  45              


Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val 
    50                  55                  60                  


Ser Ser Val Leu Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Thr Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala 
                85                  90                  95      


Asn Ile Thr Lys Ser 
            100     


<210>  132
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  132

Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu 
1               5                   10                  15      


Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly 
            20                  25                  30          


Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu 
        35                  40                  45              


Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser 
    50                  55                  60                  


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala 
65                  70                  75                  80  


Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu 
                85                  90                  95      


Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
            100                 105                 110         


Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  133
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  133

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro 
    50                  55              


<210>  134
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  134

Glu Cys Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro 
1               5                   10                  15      


Ala Val Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe 
            20                  25                  30          


Val Val Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala 
        35                  40                  45              


Gly Lys Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His 
    50                  55                  60                  


Ser Asn Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser 
65                  70                  75                  80  


Leu Trp Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser 
                85                  90                  95      


Leu Pro Pro Gln Arg Leu Met Ala Leu Arg Glu Pro 
            100                 105             


<210>  135
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  135

Ala Ala Gln Ala Pro Val Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser 
1               5                   10                  15      


Asp Pro Pro Glu Ala Ala Ser Trp Leu Leu Cys Glu Val Ser Gly Phe 
            20                  25                  30          


Ser Pro Pro Asn Ile Leu Leu Met Trp Leu Glu Asp Gln Arg Glu Val 
        35                  40                  45              


Asn Thr Ser Gly Phe Ala Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser 
    50                  55                  60                  


Thr Thr Phe Trp Ala Trp Ser Val Leu Arg Val Pro Ala Pro Pro Ser 
65                  70                  75                  80  


Pro Gln Pro Ala Thr Tyr Thr Cys Val Val Ser His Glu Asp Ser Arg 
                85                  90                  95      


Thr Leu Leu Asn Ala Ser Arg Ser Leu Glu Val Ser Tyr Val Thr Asp 
            100                 105                 110         


His Gly Pro Met Lys 
        115         


<210>  136
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  136

Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser 
1               5                   10                  15      


Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys 
            20                  25                  30          


Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu 
        35                  40                  45              


Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln 
    50                  55                  60                  


Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys 
65                  70                  75                  80  


His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly 
                85                  90                  95      


His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala 
            100                 105         


<210>  137
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  137

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val 
            20                  25                  30          


Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala 
        35                  40                  45              


Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg 
    50                  55                  60                  


Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp 
65                  70                  75                  80  


Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu 
                85                  90                  95      


Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser 
            100                 105             


<210>  138
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  138

Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
1               5                   10                  15      


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
            20                  25                  30          


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
        35                  40                  45              


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
    50                  55                  60                  


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
65                  70                  75                  80  


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
                85                  90                  95      


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
            100                 105                 110 


<210>  139
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  139

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  140
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  140

Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10      


<210>  141
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  141

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  142
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  142

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  143
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys 
225                 


<210>  144
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  144

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  145
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  145

Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            100                 105                 


<210>  146
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  146

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  147
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  147

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          


<210>  148
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  148

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            100                 105                 110 


<210>  149
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  149

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  150
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  150

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  151
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  151

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  152
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  152

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  153
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  153

Val Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg 
1               5                   10                  15      


Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala 
            20                  25                  30          


Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly 
        35                  40                  45              


Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala 
    50                  55                  60                  


Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile 
65                  70                  75                  80  


Lys Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp 
                85                  90                  95      


His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro 
            100                 105                 110         


<210>  154
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  154

Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala 
1               5                   10                  15      


Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp 
            20                  25                  30          


Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly 
        35                  40                  45              


Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala 
    50                  55                  60                  


Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn 
65                  70                  75                  80  


Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser 
                85                  90                  95      


Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys 
            100                 105     


<210>  155
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  155

Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg 
1               5                   10                  15      


Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr 
            20                  25                  30          


Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln 
        35                  40                  45              


Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro 
    50                  55                  60                  


Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu 
65                  70                  75                  80  


Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala His Glu 
                85                  90                  95      


Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly 
            100                 105                 110         


Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  156
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  156

Met Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu 
225                 230                 235                 240 


Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu 
                245                 250                 255     


Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu 
            260                 265                 270         


Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
        275                 280                 285         


<210>  157
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  157

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            260                 265                 270         


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
        275                 280                 285             


<210>  158
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  158

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Ser Asp Lys Thr 
    50                  55                  60                  


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
65                  70                  75                  80  


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                85                  90                  95      


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            100                 105                 110         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        115                 120                 125             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    130                 135                 140                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
145                 150                 155                 160 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                165                 170                 175     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            180                 185                 190         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        195                 200                 205             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    210                 215                 220                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
225                 230                 235                 240 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                245                 250                 255     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            260                 265                 270         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        275                 280                 285             


<210>  159
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  159

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            260                 265                 270         


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
        275                 280                 285             


<210>  160
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  160

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Ser Asp Lys Thr 
    50                  55                  60                  


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
65                  70                  75                  80  


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                85                  90                  95      


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            100                 105                 110         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        115                 120                 125             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    130                 135                 140                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
145                 150                 155                 160 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                165                 170                 175     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            180                 185                 190         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        195                 200                 205             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    210                 215                 220                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
225                 230                 235                 240 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                245                 250                 255     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            260                 265                 270         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        275                 280                 285             


<210>  161
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  161

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys 
            260                 265             


<210>  162
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  162

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            260                 265                 270         


Leu 
    


<210>  163
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  163

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            260                 265                 270         


Leu Gly Pro Asp Glu Ser 
        275             


<210>  164
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  164

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            260                 265                 270         


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val 
        275                 280             


<210>  165
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  165

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            260                 265                 270         


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
        275                 280                 285             


Gly Thr Arg Asp Tyr Ser 
    290                 


<210>  166
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  166

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Ser Asp Lys Thr His Thr Cys Pro 
        35                  40                  45              


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    50                  55                  60                  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
65                  70                  75                  80  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                85                  90                  95      


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            100                 105                 110         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        115                 120                 125             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    130                 135                 140                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
145                 150                 155                 160 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                165                 170                 175     


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            180                 185                 190         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        195                 200                 205             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    210                 215                 220                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
225                 230                 235                 240 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                245                 250                 255     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 265             


<210>  167
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  167

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Ser Asp Lys 
        35                  40                  45              


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                85                  90                  95      


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            260                 265                 270         


Lys 
    


<210>  168
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  168

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    50                  55                  60                  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
65                  70                  75                  80  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                85                  90                  95      


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            100                 105                 110         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        115                 120                 125             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    130                 135                 140                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
145                 150                 155                 160 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                165                 170                 175     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
            180                 185                 190         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        195                 200                 205             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    210                 215                 220                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
225                 230                 235                 240 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                245                 250                 255     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            260                 265                 270         


Ser Leu Ser Pro Gly Lys 
        275             


<210>  169
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  169

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Ser Asp Lys Thr His Thr Cys Pro Pro 
    50                  55                  60                  


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
65                  70                  75                  80  


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                85                  90                  95      


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            100                 105                 110         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        115                 120                 125             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    130                 135                 140                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
145                 150                 155                 160 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                165                 170                 175     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            180                 185                 190         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        195                 200                 205             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    210                 215                 220                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
225                 230                 235                 240 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                245                 250                 255     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            260                 265                 270         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        275                 280             


<210>  170
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  170

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    130                 135                 140                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  171
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: HRS-Fc fusion protein

<400>  171

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            260                 265                 270         


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
        275                 280                 285             


Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg 
    290                 295                 300                 


Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu 
305                 310                 315                 320 


Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu 
                325                 330                 335     


Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
            340                 345         


<210>  172
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro 
            500                 505 


<210>  173
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - HRS-COMP Fusion Protein

<400>  173

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
            20                  25                  30          


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
        35                  40                  45              


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
    50                  55                  60                  


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Gly Gly Gly 
65                  70                  75                  80  


Ser Gly Gly Gly Gly Ser Ser Asp Leu Gly Pro Gln Met Leu Arg Glu 
                85                  90                  95      


Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val Arg Glu Leu Leu Arg 
            100                 105                 110         


Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn Thr Val Met Glu Cys 
        115                 120                 125             


Asp Ala Cys Gly Gly Gly Gly Gly Ser Glu Gln Lys Leu Ile Ser Glu 
    130                 135                 140                 


Glu Asp Leu Asn Met His Thr Gly His His His His His His 
145                 150                 155             


<210>  174
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - HRS-COMP Fusion Protein

<400>  174

Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg 
1               5                   10                  15      


Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu 
            20                  25                  30          


Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu 
        35                  40                  45              


Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Gly Gly Gly Ser 
    50                  55                  60                  


Gly Gly Gly Gly Ser Ser Asp Leu Gly Pro Gln Met Leu Arg Glu Leu 
65                  70                  75                  80  


Gln Glu Thr Asn Ala Ala Leu Gln Asp Val Arg Glu Leu Leu Arg Gln 
                85                  90                  95      


Gln Val Arg Glu Ile Thr Phe Leu Lys Asn Thr Val Met Glu Cys Asp 
            100                 105                 110         


Ala Cys Gly Gly Gly Gly Gly Ser Glu Gln Lys Leu Ile Ser Glu Glu 
        115                 120                 125             


Asp Leu Asn Met His Thr Gly His His His His His His 
    130                 135                 140     


<210>  175
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - HRS-COMP Fusion Protein

<400>  175

Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val 
1               5                   10                  15      


Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu 
            20                  25                  30          


Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser 
        35                  40                  45              


Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Ser Ser Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln 
65                  70                  75                  80  


Glu Thr Asn Ala Ala Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln 
                85                  90                  95      


Val Arg Glu Ile Thr Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala 
            100                 105                 110         


Cys 
    


<210>  176
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Arg Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Glu Asn Phe Lys Val Asp Ile 
                805                 810                 815     


Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu 
            820                 825                 830         


Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly 
        835                 840                 845             


Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro 
    850                 855                 860                 


Ile Leu Ile Thr Ile Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly 
865                 870                 875                 880 


Ala Thr Cys Ala Gly Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly 
                885                 890                 895     


Leu Ser Ser Arg Ser Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu 
            900                 905                 910         


Tyr Asp Gly Leu Lys His Lys Val Lys Met Asn His Gln Lys Cys Cys 
        915                 920                 925             


Ser Glu Ala 
    930     


<210>  177
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Val Asp Ile Pro Glu Ile His Glu 
                805                 810                 815     


Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu Tyr Glu Val Asp Trp 
            820                 825                 830         


Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp 
        835                 840                 845             


Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile 
    850                 855                 860                 


Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly Ala Thr Cys Ala Gly 
865                 870                 875                 880 


Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser 
                885                 890                 895     


Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys 
            900                 905                 910         


His Lys Val Lys Met Asn His Gln Lys Cys Cys Ser Glu Ala 
        915                 920                 925     


<210>  178
<211>  909
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Asp Glu Tyr Glu Val Asp Trp Ser 
                805                 810                 815     


Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp Lys 
            820                 825                 830         


Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile 
        835                 840                 845             


Ala Met Ser Ser Leu Gly Val Leu Leu Gly Ala Thr Cys Ala Gly Leu 
    850                 855                 860                 


Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser Cys 
865                 870                 875                 880 


Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys His 
                885                 890                 895     


Lys Val Lys Met Asn His Gln Lys Cys Cys Ser Glu Ala 
            900                 905                 


<210>  179
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Glu Asn Phe Lys Gly Gly Thr 
                805                 810                 815     


Leu Leu Pro Gly Thr Glu Pro Thr Val Asp Thr Val Pro Met Gln Pro 
            820                 825                 830         


Ile Pro Ala Tyr Trp Tyr Tyr Val Met Ala Ala Gly Gly Ala Val Leu 
        835                 840                 845             


Val Leu Val Ser Val Ala Leu Ala Leu Val Leu His Tyr His Arg Phe 
    850                 855                 860                 


Arg Tyr Ala Ala Lys Lys Thr Asp His Ser Ile Thr Tyr Lys Thr Ser 
865                 870                 875                 880 


His Tyr Thr Asn Gly Ala Pro Leu Ala Val Glu Pro Thr Leu Thr Ile 
                885                 890                 895     


Lys Leu Glu Gln Asp Arg Gly Ser His Cys 
            900                 905     


<210>  180
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Gly Thr Leu Leu Pro Gly Thr 
                805                 810                 815     


Glu Pro Thr Val Asp Thr Val Pro Met Gln Pro Ile Pro Ala Tyr Trp 
            820                 825                 830         


Tyr Tyr Val Met Ala Ala Gly Gly Ala Val Leu Val Leu Val Ser Val 
        835                 840                 845             


Ala Leu Ala Leu Val Leu His Tyr His Arg Phe Arg Tyr Ala Ala Lys 
    850                 855                 860                 


Lys Thr Asp His Ser Ile Thr Tyr Lys Thr Ser His Tyr Thr Asn Gly 
865                 870                 875                 880 


Ala Pro Leu Ala Val Glu Pro Thr Leu Thr Ile Lys Leu Glu Gln Asp 
                885                 890                 895     


Arg Gly Ser His Cys 
            900     


<210>  181
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Val Gly Cys Ser Trp Arg Pro Leu 
545                 550                 555 


<210>  182
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  182

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn Met Leu 
                405                 410                 415     


Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser Ser 
            420                 425                 430         


Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser Ser 
        435                 440                 445             


Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu Glu 
    450                 455                 460                 


Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val Ile 
465                 470                 475                 480 


Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala Arg 
                485                 490                 495     


Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys Asp 
            500                 505                 510         


Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe Glu 
        515                 520                 525             


Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro Ile 
    530                 535                 540                 


Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala Gly 
545                 550                 555                 560 


Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr Asp Ser Lys 
                565                 570                 575     


Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu Glu Thr Thr 
            580                 585                 590         


Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly Glu Asn Cys 
        595                 600                 605             


Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly Phe Asn Cys 
    610                 615                 620                 


Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr Asp His Ala 
625                 630                 635                 640 


Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro Asn Asp Arg 
                645                 650                 655     


Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser Asp Ser Gln 
            660                 665                 670         


Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val His Leu Pro 
        675                 680                 685             


Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr Gly Gly Arg 
    690                 695                 700                 


Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu Ser Lys Leu 
705                 710                 715                 720 


Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys His Gly Arg 
                725                 730                 735     


Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val Phe Glu Gly 
            740                 745                 750         


Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp Asp Ile Arg 
        755                 760                 765             


Ile Ser Thr Asp Val Pro Leu Glu Asn Cys Met Glu Pro Ile Ser Ala 
    770                 775                 780                 


Phe Ala Val Asp Ile Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp 
785                 790                 795                 800 


Glu Ile Asp Asp Glu Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala 
                805                 810                 815     


Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu 
            820                 825                 830         


Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met Ser Ser Leu 
        835                 840                 845             


Gly Val Leu Leu Gly Ala Thr Cys Ala Gly Leu Leu Leu Tyr Cys Thr 
    850                 855                 860                 


Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser Cys Thr Thr Leu Glu Asn 
865                 870                 875                 880 


Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys His Lys Val Lys Met Asn 
                885                 890                 895     


His Gln Lys Cys Cys Ser Glu Ala 
            900                 


<210>  183
<211>  879
<212>  PRT
<213>  Homo sapiens

<400>  183

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn Met Leu 
                405                 410                 415     


Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser Ser 
            420                 425                 430         


Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser Ser 
        435                 440                 445             


Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu Glu 
    450                 455                 460                 


Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val Ile 
465                 470                 475                 480 


Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala Arg 
                485                 490                 495     


Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys Asp 
            500                 505                 510         


Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe Glu 
        515                 520                 525             


Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro Ile 
    530                 535                 540                 


Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala Gly 
545                 550                 555                 560 


Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr Asp Ser Lys 
                565                 570                 575     


Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu Glu Thr Thr 
            580                 585                 590         


Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly Glu Asn Cys 
        595                 600                 605             


Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly Phe Asn Cys 
    610                 615                 620                 


Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr Asp His Ala 
625                 630                 635                 640 


Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro Asn Asp Arg 
                645                 650                 655     


Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser Asp Ser Gln 
            660                 665                 670         


Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val His Leu Pro 
        675                 680                 685             


Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr Gly Gly Arg 
    690                 695                 700                 


Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu Ser Lys Leu 
705                 710                 715                 720 


Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys His Gly Arg 
                725                 730                 735     


Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val Phe Glu Gly 
            740                 745                 750         


Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp Asp Ile Arg 
        755                 760                 765             


Ile Ser Thr Asp Val Pro Leu Glu Asn Cys Met Glu Pro Ile Ser Ala 
    770                 775                 780                 


Phe Ala Gly Gly Thr Leu Leu Pro Gly Thr Glu Pro Thr Val Asp Thr 
785                 790                 795                 800 


Val Pro Met Gln Pro Ile Pro Ala Tyr Trp Tyr Tyr Val Met Ala Ala 
                805                 810                 815     


Gly Gly Ala Val Leu Val Leu Val Ser Val Ala Leu Ala Leu Val Leu 
            820                 825                 830         


His Tyr His Arg Phe Arg Tyr Ala Ala Lys Lys Thr Asp His Ser Ile 
        835                 840                 845             


Thr Tyr Lys Thr Ser His Tyr Thr Asn Gly Ala Pro Leu Ala Val Glu 
    850                 855                 860                 


Pro Thr Leu Thr Ile Lys Leu Glu Gln Asp Arg Gly Ser His Cys 
865                 870                 875                 


<210>  184
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  184

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn Met Leu 
                405                 410                 415     


Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser Ser 
            420                 425                 430         


Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser Ser 
        435                 440                 445             


Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu Glu 
    450                 455                 460                 


Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val Ile 
465                 470                 475                 480 


Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala Arg 
                485                 490                 495     


Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys Asp 
            500                 505                 510         


Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Val Gly Cys 
        515                 520                 525             


Ser Trp Arg Pro Leu 
    530             


<210>  185
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  185

Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro 
1               5                   10                  15      


Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val 
            20                  25                  30          


Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His 
        35                  40                  45              


Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg 
    50                  55                  60                  


Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn 
65                  70                  75                  80  


Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys 
                85                  90                  95      


Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr 
            100                 105                 110         


Glu Ile 
        


<210>  186
<211>  117
<212>  PRT
<213>  Homo sapies

<400>  186

Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly 
1               5                   10                  15      


Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu 
            20                  25                  30          


Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu 
        35                  40                  45              


Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp 
    50                  55                  60                  


Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys 
65                  70                  75                  80  


Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile 
                85                  90                  95      


Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe 
            100                 105                 110         


Ser Ala Arg Tyr Tyr 
        115         


<210>  187
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  187

Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser Ala 
1               5                   10                  15      


Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg Leu 
            20                  25                  30          


His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys Glu 
        35                  40                  45              


Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile Ala 
    50                  55                  60                  


Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val Lys 
65                  70                  75                  80  


Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val Tyr 
                85                  90                  95      


Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala Thr 
            100                 105                 110         


Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe Val 
        115                 120                 125             


Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu Glu 
    130                 135                 140                 


Leu Phe Gly 
145         


<210>  188
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  188

Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser 
1               5                   10                  15      


Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser 
            20                  25                  30          


Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu 
        35                  40                  45              


Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val 
    50                  55                  60                  


Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala 
65                  70                  75                  80  


Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys 
                85                  90                  95      


Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe 
            100                 105                 110         


Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro 
        115                 120                 125             


Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala 
    130                 135                 140                 


Gly Ile Gly Met Arg Leu Glu Val Leu Gly 
145                 150                 


<210>  189
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  189

Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
1               5                   10                  15      


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            20                  25                  30          


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        35                  40                  45              


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    50                  55                  60                  


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
65                  70                  75                  80  


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                85                  90                  95      


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            100                 105                 110         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        115                 120                 125             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    130                 135                 140                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp 
145                 150                 


<210>  190
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  190

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr 
            


<210>  191
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  191

Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly 
1               5                   10                  15      


Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu 
            20                  25                  30          


Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu 
        35                  40                  45              


Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp 
    50                  55                  60                  


Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys 
65                  70                  75                  80  


Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile 
                85                  90                  95      


Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe 
            100                 105                 110         


Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln 
        115                 120                 125             


Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln 
    130                 135                 140                 


Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln 
145                 150                 155                 160 


Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser 
                165                 170                 175     


Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr 
            180                 185                 190         


Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr 
        195                 200                 205             


Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp 
    210                 215                 220                 


Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn 
225                 230                 235                 240 


Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr 
                245                 250                 255     


Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu 
            260                 265                 270         


Arg Leu Glu Leu Phe Gly 
        275             


<210>  192
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  192

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly 
                


<210>  193
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  193

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn Met Leu 
                405                 410                 415     


Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser Ser 
            420                 425                 430         


Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser Ser 
        435                 440                 445             


Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu Glu 
    450                 455                 460                 


Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val Ile 
465                 470                 475                 480 


Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala Arg 
                485                 490                 495     


Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys Asp 
            500                 505                 510         


Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe Glu 
        515                 520                 525             


Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro Ile 
    530                 535                 540                 


Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala Gly 
545                 550                 555                 560 


Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr 
                565                 570             


<210>  194
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  194

Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
1               5                   10                  15      


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
            20                  25                  30          


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
        35                  40                  45              


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
    50                  55                  60                  


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
65                  70                  75                  80  


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
                85                  90                  95      


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
            100                 105                 110         


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
        115                 120                 125             


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
    130                 135                 140                 


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
145                 150                 155                 160 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
                165                 170                 175     


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
            180                 185                 190         


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
        195                 200                 205             


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
    210                 215                 220                 


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
225                 230                 235                 240 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
                245                 250                 255     


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
            260                 265                 270         


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
        275                 280                 285             


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
    290                 295                 300                 


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
305                 310                 315                 320 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
                325                 330                 335     


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
            340                 345                 350         


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
        355                 360                 365             


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
    370                 375                 380                 


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
385                 390                 395                 400 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
                405                 410                 415     


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
            420                 425                 430         


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
        435                 440                 445             


Asp Trp Thr 
    450     


<210>  195
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  195

Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu 
1               5                   10                  15      


Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln 
            20                  25                  30          


Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp 
        35                  40                  45              


Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu 
    50                  55                  60                  


Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly 
65                  70                  75                  80  


Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp 
                85                  90                  95      


Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn 
            100                 105                 110         


Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu 
        115                 120                 125             


Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala 
    130                 135                 140                 


Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser 
145                 150                 155                 160 


Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser 
                165                 170                 175     


Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu 
            180                 185                 190         


Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro 
        195                 200                 205             


Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys 
    210                 215                 220                 


Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val 
225                 230                 235                 240 


Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn 
                245                 250                 255     


Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys 
            260                 265                 270         


Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe 
        275                 280                 285             


Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser 
    290                 295                 300                 


Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr 
305                 310                 315                 320 


<210>  196
<211>  1060
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - NRP2 v2 Fc fusion protein construct

<400>  196

Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp Ala Gly 
1               5                   10                  15      


Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His Gln Asn 
            20                  25                  30          


Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile Val Leu 
        35                  40                  45              


Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu Leu Gly 
65                  70                  75                  80  


Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser Gly Ser 
                85                  90                  95      


Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly Ala Gly 
            100                 105                 110         


Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp Cys Ser 
        115                 120                 125             


Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro 
    130                 135                 140                 


Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu Ala Lys 
145                 150                 155                 160 


Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu Glu His 
                165                 170                 175     


Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp Leu Asp 
            180                 185                 190         


Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys Tyr Cys 
        195                 200                 205             


Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile Leu Ser 
    210                 215                 220                 


Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe Ser Ala 
225                 230                 235                 240 


Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn 
                245                 250                 255     


Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln Ile Ser 
            260                 265                 270         


Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln Ser Arg 
        275                 280                 285             


Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser Asn Lys 
    290                 295                 300                 


Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr Ala Ile 
305                 310                 315                 320 


Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr Tyr Val 
                325                 330                 335     


Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp Met Val 
            340                 345                 350         


Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn Asp Ala 
        355                 360                 365             


Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr Arg Phe 
    370                 375                 380                 


Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg Leu 
385                 390                 395                 400 


Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn Met Leu 
                405                 410                 415     


Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser Ser 
            420                 425                 430         


Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser Ser 
        435                 440                 445             


Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu Glu 
    450                 455                 460                 


Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val Ile 
465                 470                 475                 480 


Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala Arg 
                485                 490                 495     


Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys Asp 
            500                 505                 510         


Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe Glu 
        515                 520                 525             


Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro Ile 
    530                 535                 540                 


Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala Gly 
545                 550                 555                 560 


Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr Asp Ser Lys 
                565                 570                 575     


Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu Glu Thr Thr 
            580                 585                 590         


Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly Glu Asn Cys 
        595                 600                 605             


Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly Phe Asn Cys 
    610                 615                 620                 


Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr Asp His Ala 
625                 630                 635                 640 


Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro Asn Asp Arg 
                645                 650                 655     


Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser Asp Ser Gln 
            660                 665                 670         


Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val His Leu Pro 
        675                 680                 685             


Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr Gly Gly Arg 
    690                 695                 700                 


Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu Ser Lys Leu 
705                 710                 715                 720 


Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys His Gly Arg 
                725                 730                 735     


Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val Phe Glu Gly 
            740                 745                 750         


Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp Asp Ile Arg 
        755                 760                 765             


Ile Ser Thr Asp Val Pro Leu Glu Asn Cys Met Glu Pro Ile Ser Ala 
    770                 775                 780                 


Phe Ala Val Asp Ile Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp 
785                 790                 795                 800 


Glu Ile Asp Asp Glu Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala 
                805                 810                 815     


Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu 
            820                 825                 830         


Tyr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        835                 840                 845             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    850                 855                 860                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
865                 870                 875                 880 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                885                 890                 895     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            900                 905                 910         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        915                 920                 925             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    930                 935                 940                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
945                 950                 955                 960 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                965                 970                 975     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            980                 985                 990         


Glu Trp Glu Ser Asn Gly Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro 
        995                 1000                 1005             


Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu 
    1010                 1015                 1020             


Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys 
    1025                 1030                 1035             


Ser Val  Met His Glu Ala Leu  His Asn His Tyr Thr  Gln Lys Ser 
    1040                 1045                 1050             


Leu Ser  Leu Ser Pro Gly Lys  
    1055                 1060 


<210>  197
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - NRP2 A2B1B2-Fc fusion protein construct

<400>  197

Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
1               5                   10                  15      


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
            20                  25                  30          


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
        35                  40                  45              


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
    50                  55                  60                  


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
65                  70                  75                  80  


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
                85                  90                  95      


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
            100                 105                 110         


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
        115                 120                 125             


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
    130                 135                 140                 


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
145                 150                 155                 160 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
                165                 170                 175     


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
            180                 185                 190         


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
        195                 200                 205             


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
    210                 215                 220                 


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
225                 230                 235                 240 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
                245                 250                 255     


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
            260                 265                 270         


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
        275                 280                 285             


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
    290                 295                 300                 


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
305                 310                 315                 320 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
                325                 330                 335     


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
            340                 345                 350         


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
        355                 360                 365             


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
    370                 375                 380                 


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
385                 390                 395                 400 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
                405                 410                 415     


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
            420                 425                 430         


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
        435                 440                 445             


Asp Trp Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    450                 455                 460                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
465                 470                 475                 480 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                485                 490                 495     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            500                 505                 510         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        515                 520                 525             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    530                 535                 540                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
545                 550                 555                 560 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                565                 570                 575     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            580                 585                 590         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        595                 600                 605             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    610                 615                 620                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
625                 630                 635                 640 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                645                 650                 655     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            660                 665                 670         


Ser Leu Ser Pro Gly Lys 
        675             


<210>  198
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  198

Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala Ser 
1               5                   10                  15      


Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val Ser 
            20                  25                  30          


Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly Glu 
        35                  40                  45              


Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly Val 
    50                  55                  60                  


Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu Ala 
65                  70                  75                  80  


Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly Lys 
                85                  90                  95      


Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu Phe 
            100                 105                 110         


Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp Pro 
        115                 120                 125             


Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro Ala 
    130                 135                 140                 


Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr Asp Ser 
145                 150                 155                 160 


Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu Glu Thr 
                165                 170                 175     


Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly Glu Asn 
            180                 185                 190         


Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly Phe Asn 
        195                 200                 205             


Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr Asp His 
    210                 215                 220                 


Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro Asn Asp 
225                 230                 235                 240 


Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser Asp Ser 
                245                 250                 255     


Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val His Leu 
            260                 265                 270         


Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr Gly Gly 
        275                 280                 285             


Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu Ser Lys 
    290                 295                 300                 


Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys His Gly 
305                 310                 315                 320 


Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val Phe Glu 
                325                 330                 335     


Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp Asp Ile 
            340                 345                 350         


Arg Ile Ser Thr Asp 
        355         


<210>  199
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  199

Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu 
1               5                   10                  15      


Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln 
            20                  25                  30          


Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp 
        35                  40                  45              


Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu 
    50                  55                  60                  


Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly 
65                  70                  75                  80  


Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp 
                85                  90                  95      


Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn 
            100                 105                 110         


Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu 
        115                 120                 125             


Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala 
    130                 135                 140                 


Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser 
145                 150                 155                 160 


Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser 
                165                 170                 175     


Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu 
            180                 185                 190         


Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro 
        195                 200                 205             


Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys 
    210                 215                 220                 


Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val 
225                 230                 235                 240 


Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn 
                245                 250                 255     


Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys 
            260                 265                 270         


Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe 
        275                 280                 285             


Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser 
    290                 295                 300                 


Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr 
305                 310                 315                 320 


Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu 
                325                 330                 335     


Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly 
            340                 345                 350         


Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly 
        355                 360                 365             


Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr 
    370                 375                 380                 


Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro 
385                 390                 395                 400 


Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser 
                405                 410                 415     


Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val 
            420                 425                 430         


His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr 
        435                 440                 445             


Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu 
    450                 455                 460                 


Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys 
465                 470                 475                 480 


His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val 
                485                 490                 495     


Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp 
            500                 505                 510         


Asp Ile Arg Ile Ser Thr Asp 
        515                 


<210>  200
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - optimized nucleic acid sequence of 
       SPARC-HRS(2-60)-COMP-MycHIS construct

<400>  200
atgagggcct ggattttctt tctgctgtgc ctggctggca gagctctggc tgctgagaga       60

gccgccctgg aggagctggt caagctgcag ggcgagaggg tgaggggcct gaagcagcag      120

aaggccagcg ccgagctgat cgaggaggag gtggccaagc tgctgaagct gaaggcccag      180

ctcggccctg acgagagcaa gcagaagttc gtgctgaaga cacccaaggg aggaggcgga      240

tccggaggag gaggaagcag cgatctgggc ccccagatgc tgagggagct gcaggagaca      300

aacgccgccc tgcaggacgt gagagagctg ctgagacagc aggtgaggga gatcaccttc      360

ctgaagaaca ccgtgatgga gtgcgacgcc tgtggaggag gaggaggcag cgagcagaag      420

ctgatcagcg aggaggacct gaacatgcac accggccatc accatcacca ccactga         477


<210>  201
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  201

Gly Ser Gly Ser 
1               


<210>  202
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  202

Gly Gly Ser Gly 
1               


<210>  203
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  203

Gly Gly Gly Ser 
1               


<210>  204
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  204

Gly Gly Gly Gly Ser 
1               5   


<210>  205
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  205

Gly Asn Gly Asn 
1               


<210>  206
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  206

Gly Gly Asn Gly 
1               


<210>  207
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  207

Gly Gly Gly Asn 
1               


<210>  208
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  208

Gly Gly Gly Gly Asn 
1               5   


<210>  209
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  209

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  210
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  210

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser 
            20          


<210>  211
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  211

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  212
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  212

Asp Ala Ala Ala Lys Glu Ala Ala Ala Lys Asp Ala Ala Ala Arg Glu 
1               5                   10                  15      


Ala Ala Ala Arg Asp Ala Ala Ala Lys 
            20                  25  


<210>  213
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  213

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
1               5                   10                  


<210>  214
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  214

Asp Gly Gly Gly Ser 
1               5   


<210>  215
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  215

Thr Gly Glu Lys Pro 
1               5   


<210>  216
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  216

Gly Gly Arg Arg 
1               


<210>  217
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  217

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  218
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  218

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  219
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  219

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  220
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  220

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  221
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  221

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  222
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab: peptide linker sequence

<400>  222

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  223
<211>  19
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  223

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  224
<211>  19
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  224

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  225
<211>  14
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  225

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  226
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  226

Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  227
<211>  20
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  227

Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  228
<211>  24
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  228

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  229
<211>  40
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  229

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            20                  25                  30          


Ile Val Ala Pro Val Lys Gln Thr 
        35                  40  


<210>  230
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  230

Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  231
<211>  40
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  231

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  232
<211>  33
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  232

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  233
<211>  7
<212>  PRT
<213>  Tobacco etch virus


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa = any amino acid

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa = any amino acid

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = any amino acid

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is either Gly or Ser

<400>  233

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  234
<211>  7
<212>  PRT
<213>  Tobacco etch virus

<400>  234

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  235
<211>  7
<212>  PRT
<213>  Tabacco etch virus

<400>  235

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  236
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin cleavable linker

<400>  236

Gly Arg Gly Asp 
1               


<210>  237
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin cleavable linker

<400>  237

Gly Arg Gly Asp Asn Pro 
1               5       


<210>  238
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin cleavable linker

<400>  238

Gly Arg Gly Asp Ser 
1               5   


<210>  239
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin cleavable linker

<400>  239

Gly Arg Gly Asp Ser Pro Lys 
1               5           


<210>  240
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  240

Ala Ala Pro Val 
1               


<210>  241
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  241

Ala Ala Pro Leu 
1               


<210>  242
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  242

Ala Ala Pro Phe 
1               


<210>  243
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  243

Ala Ala Pro Ala 
1               


<210>  244
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  244

Ala Tyr Leu Val 
1               


<210>  245
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase cleavable linker


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa = Any amino acid

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = Any amino acid

<400>  245

Gly Pro Xaa Gly Pro Xaa 
1               5       


<210>  246
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase cleavable linker


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa = Any amino acid

<400>  246

Leu Gly Pro Xaa 
1               


<210>  247
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase cleavable linker


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = Any amino acid

<400>  247

Gly Pro Ile Gly Pro Xaa 
1               5       


<210>  248
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase cleavable linker


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = Any amino acid

<400>  248

Ala Pro Gly Leu Xaa 
1               5   


<210>  249
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = Any amino acid

<400>  249

Pro Leu Gly Pro Asp Arg Xaa 
1               5           


<210>  250
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = Any amino acid

<400>  250

Pro Leu Gly Leu Leu Gly Xaa 
1               5           


<210>  251
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  251

Pro Gln Gly Ile Ala Gly Trp 
1               5           


<210>  252
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  252

Pro Leu Gly Cys His 
1               5   


<210>  253
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  253

Pro Leu Gly Leu Tyr Ala 
1               5       


<210>  254
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  254

Pro Leu Ala Leu Trp Ala Arg 
1               5           


<210>  255
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  255

Pro Leu Ala Tyr Trp Ala Arg 
1               5           


<210>  256
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stromelysin cleavable linker

<400>  256

Pro Tyr Ala Tyr Tyr Met Arg 
1               5           


<210>  257
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gelatinase cleavable linker

<400>  257

Pro Leu Gly Met Tyr Ser Arg 
1               5           


<210>  258
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin converting enzyme cleavable linker

<400>  258

Gly Asp Lys Pro 
1               


<210>  259
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin converting enzyme cleavable linker

<400>  259

Gly Ser Asp Lys Pro 
1               5   


<210>  260
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cathepsin B cleavable linker

<400>  260

Ala Leu Ala Leu 
1               


<210>  261
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cathepsin B cleavable linker

<400>  261

Gly Phe Leu Gly 
1               


<210>  262
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Myc-His tag construct

<400>  262

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Met His Thr Gly His 
1               5                   10                  15      


His His His His His 
            20      


<210>  263
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  263
gctggcagag ctctggctgg aggaggcgga tccgga                                 36


<210>  264
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  264
tccggatccg cctcctccag ccagagctct gccagc                                 36


