                         SEQUENCE LISTING

<110>  Kim, Yon Son B.
       Jiang, Wen
 
<120>  METHODS AND MATERIALS FOR TREATING CANCER

<130>  07039-1810WO1

<150>  US 62/711,380
<151>  2018-07-27

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  202
<212>  PRT
<213>  Mus musculus

<400>  1

Ser Gly Thr Leu Lys Lys Val Ala Gly Ala Leu Asp Gly Ser Val Thr 
1               5                   10                  15      


Phe Thr Leu Asn Ile Thr Glu Ile Lys Val Asp Tyr Val Val Trp Thr 
            20                  25                  30          


Phe Asn Thr Phe Phe Leu Ala Met Val Lys Lys Asp Gly Val Thr Ser 
        35                  40                  45              


Gln Ser Ser Asn Lys Glu Arg Ile Val Phe Pro Asp Gly Leu Tyr Ser 
    50                  55                  60                  


Met Lys Leu Ser Gln Leu Lys Lys Asn Asp Ser Gly Ala Tyr Arg Ala 
65                  70                  75                  80  


Glu Ile Tyr Ser Thr Ser Ser Gln Ala Ser Leu Ile Gln Glu Tyr Val 
                85                  90                  95      


Leu His Val Tyr Lys His Leu Ser Arg Pro Lys Val Thr Ile Asp Arg 
            100                 105                 110         


Gln Ser Asn Lys Asn Gly Thr Cys Val Ile Asn Leu Thr Cys Ser Thr 
        115                 120                 125             


Asp Gln Asp Gly Glu Asn Val Thr Tyr Ser Trp Lys Ala Val Gly Gln 
    130                 135                 140                 


Gly Asp Asn Gln Phe His Asp Gly Ala Thr Leu Ser Ile Ala Trp Arg 
145                 150                 155                 160 


Ser Gly Glu Lys Asp Gln Ala Leu Thr Cys Met Ala Arg Asn Pro Val 
                165                 170                 175     


Ser Asn Ser Phe Ser Thr Pro Val Phe Pro Gln Lys Leu Cys Glu Asp 
            180                 185                 190         


Ala Ala Thr Asp Leu Thr Ser Leu Arg Gly 
        195                 200         


<210>  2
<211>  449
<212>  PRT
<213>  Humanize Mouse

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  3
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Gly Ser Ala Ala Ser Gly Pro Val Lys Glu Leu Val Gly Ser 
            20                  25                  30          


Val Gly Gly Ala Val Thr Phe Pro Leu Lys Ser Lys Val Lys Gln Val 
        35                  40                  45              


Asp Ser Ile Val Trp Thr Phe Asn Thr Thr Pro Leu Val Thr Ile Gln 
    50                  55                  60                  


Pro Glu Gly Gly Thr Ile Ile Val Thr Gln Asn Arg Asn Arg Glu Arg 
65                  70                  75                  80  


Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys 
                85                  90                  95      


Lys Asn Asp Ser Gly Ile Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu 
            100                 105                 110         


Gln Gln Pro Ser Thr Gln Glu Tyr Val Leu His Val Tyr Glu His Leu 
        115                 120                 125             


Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser Asn Lys Asn Gly Thr 
    130                 135                 140                 


Cys Val Thr Asn Leu Thr Cys Cys Met Glu His Gly Glu Glu Asp Val 
145                 150                 155                 160 


Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala Asn Glu Ser His Asn 
                165                 170                 175     


Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly Glu Ser Asp Met Thr 
            180                 185                 190         


Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg Asn Phe Ser Ser Pro 
        195                 200                 205             


Ile Leu Ala Arg Lys Leu Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser 
    210                 215                 220                 


Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro Leu Leu Leu Ser Leu 
225                 230                 235                 240 


Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys Arg Glu Arg Gln Glu 
                245                 250                 255     


Glu Tyr Ile Glu Glu Lys Lys Arg Val Asp Ile Cys Arg Glu Thr Pro 
            260                 265                 270         


Asn Ile Cys Pro His Ser Gly Glu Asn Thr Glu Tyr Asp Thr Ile Pro 
        275                 280                 285             


His Thr Asn Arg Thr Ile Leu Lys Glu Asp Pro Ala Asn Thr Val Tyr 
    290                 295                 300                 


Ser Thr Val Glu Ile Pro Lys Lys Met Glu Asn Pro His Ser Leu Leu 
305                 310                 315                 320 


Thr Met Pro Asp Thr Pro Arg Leu Phe Ala Tyr Glu Asn Val Ile 
                325                 330                 335 


<210>  4
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Gly Pro Val Lys Glu Leu Val Gly Ser Val Gly Gly Ala Val Thr 
1               5                   10                  15      


Phe Pro Leu Lys Ser Lys Val Lys Gln Val Asp Ser Ile Val Trp Thr 
            20                  25                  30          


Phe Asn Thr Thr Pro Leu Val Thr Ile Gln Pro Glu Gly Gly Thr Ile 
        35                  40                  45              


Ile Val Thr Gln Asn Arg Asn Arg Glu Arg Val Asp Phe Pro Asp Gly 
    50                  55                  60                  


Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys Lys Asn Asp Ser Gly Ile 
65                  70                  75                  80  


Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu Gln Gln Pro Ser Thr Gln 
                85                  90                  95      


Glu Tyr Val Leu His Val Tyr Glu His Leu Ser Lys Pro Lys Val Thr 
            100                 105                 110         


Met Gly Leu Gln Ser Asn Lys Asn Gly Thr Cys Val Thr Asn Leu Thr 
        115                 120                 125             


Cys Cys Met Glu His Gly Glu Glu Asp Val Ile Tyr Thr Trp Lys Ala 
    130                 135                 140                 


Leu Gly Gln Ala Ala Asn Glu Ser His Asn Gly Ser Ile Leu Pro Ile 
145                 150                 155                 160 


Ser Trp Arg Trp Gly Glu Ser Asp Met Thr Phe Ile Cys Val Ala Arg 
                165                 170                 175     


Asn Pro Val Ser Arg Asn Phe Ser Ser Pro Ile Leu Ala Arg Lys Leu 
            180                 185                 190         


Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser Ser Met Val Leu Leu Cys 
        195                 200                 205             


Leu Leu Leu Val Pro Leu Leu Leu Ser Leu Phe Val Leu Gly Leu Phe 
    210                 215                 220                 


Leu Trp Phe Leu Lys Arg Glu Arg Gln Glu Glu Tyr Ile Glu Glu Lys 
225                 230                 235                 240 


Lys Arg Val Asp Ile Cys Arg Glu Thr Pro Asn Ile Cys Pro His Ser 
                245                 250                 255     


Gly Glu Asn Thr Glu Tyr Asp Thr Ile Pro His Thr Asn Arg Thr Ile 
            260                 265                 270         


Leu Lys Glu Asp Pro Ala Asn Thr Val Tyr Ser Thr Val Glu Ile Pro 
        275                 280                 285             


Lys Lys Met Glu Asn Pro His Ser Leu Leu Thr Met Pro Asp Thr Pro 
    290                 295                 300                 


Arg Leu Phe Ala Tyr Glu Asn Val Ile 
305                 310             


<210>  5
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Gly Pro Val Lys Glu Leu Val Gly Ser Val Gly Gly Ala Val Thr 
1               5                   10                  15      


Phe Pro Leu Lys Ser Lys Val Lys Gln Val Asp Ser Ile Val Trp Thr 
            20                  25                  30          


Phe Asn Thr Thr Pro Leu Val Thr Ile Gln Pro Glu Gly Gly Thr Ile 
        35                  40                  45              


Ile Val Thr Gln Asn Arg Asn Arg Glu Arg Val Asp Phe Pro Asp Gly 
    50                  55                  60                  


Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys Lys Asn Asp Ser Gly Ile 
65                  70                  75                  80  


Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu Gln Gln Pro Ser Thr Gln 
                85                  90                  95      


Glu Tyr Val Leu His Val Tyr Glu His Leu Ser Lys Pro Lys Val Thr 
            100                 105                 110         


Met Gly Leu Gln Ser Asn Lys Asn Gly Thr Cys Val Thr Asn Leu Thr 
        115                 120                 125             


Cys Cys Met Glu His Gly Glu Glu Asp Val Ile Tyr Thr Trp Lys Ala 
    130                 135                 140                 


Leu Gly Gln Ala Ala Asn Glu Ser His Asn Gly Ser Ile Leu Pro Ile 
145                 150                 155                 160 


Ser Trp Arg Trp Gly Glu Ser Asp Met Thr Phe Ile Cys Val Ala Arg 
                165                 170                 175     


Asn Pro Val Ser Arg Asn Phe Ser Ser Pro Ile Leu Ala Arg Lys Leu 
            180                 185                 190         


Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser Ser Met 
        195                 200                 


<210>  6
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Gly Pro Val Lys Glu Leu Val Gly Ser Val Gly Gly Ala Val Thr 
1               5                   10                  15      


Phe Pro Leu Lys Ser Lys Val Lys Gln Val Asp Ser Ile Val Trp Thr 
            20                  25                  30          


Phe Asn Thr Thr Pro Leu Val Thr Ile Gln Pro Glu Gly Gly Thr Ile 
        35                  40                  45              


Ile Val Thr Gln Asn Arg Asn Arg Glu Arg Val Asp Phe Pro Asp Gly 
    50                  55                  60                  


Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys Lys Asn Asp Ser Gly Ile 
65                  70                  75                  80  


Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu Gln Gln Pro Ser Thr Gln 
                85                  90                  95      


Glu Tyr Val Leu His Val 
            100         


<210>  7
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  7

Pro Lys Val Thr Met Gly Leu Gln Ser Asn Lys Asn Gly Thr Cys Val 
1               5                   10                  15      


Thr Asn Leu Thr Cys Cys Met Glu His Gly Glu Glu Asp Val Ile Tyr 
            20                  25                  30          


Thr Trp Lys Ala Leu Gly Gln Ala Ala Asn Glu Ser His Asn Gly Ser 
        35                  40                  45              


Ile Leu Pro Ile Ser Trp Arg Trp Gly Glu Ser Asp Met Thr Phe Ile 
    50                  55                  60                  


Cys Val Ala Arg Asn Pro Val Ser Arg Asn Phe Ser 
65                  70                  75      


<210>  8
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Ser Val Gly Gly Ala Val Thr Phe Pro Leu Lys Ser Lys Val Lys 
1               5                   10                  15      


Gln Val Asp Ser Ile Val Trp Thr Phe Asn Thr Thr Pro Leu Val Thr 
            20                  25                  30          


Ile Gln Pro Glu Gly Gly Thr Ile Ile Val Thr Gln Asn Arg Asn Arg 
        35                  40                  45              


Glu Arg Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu Lys Leu Ser Lys 
    50                  55                  60                  


Leu Lys Lys Asn Asp Ser Gly Ile Tyr Tyr Val Gly Ile Tyr Ser Ser 
65                  70                  75                  80  


Ser Leu Gln Gln Pro Ser Thr Gln Glu Tyr Val Leu His Val Tyr 
                85                  90                  95  


<210>  9
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  9

Lys Glu Leu Val Gly Ser Val Gly Gly Ala Val Thr Phe Pro Leu Lys 
1               5                   10                  15      


Ser Lys Val Lys Gln Val Asp Ser Ile Val Trp Thr Phe Asn Thr Thr 
            20                  25                  30          


Pro Leu Val Thr Ile Gln Pro Glu Gly Gly Thr Ile Ile Val Thr Gln 
        35                  40                  45              


Asn Arg Asn Arg Glu Arg Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu 
    50                  55                  60                  


Lys Leu Ser Lys Leu Lys Lys Asn Asp Ser Gly Ile Tyr Tyr 
65                  70                  75              


<210>  10
<211>  333
<212>  PRT
<213>  Mus musculus

<400>  10

Met Ala Arg Phe Ser Thr Tyr Ile Ile Phe Thr Ser Val Leu Cys Gln 
1               5                   10                  15      


Leu Thr Val Thr Ala Ala Ser Gly Thr Leu Lys Lys Val Ala Gly Ala 
            20                  25                  30          


Leu Asp Gly Ser Val Thr Phe Thr Leu Asn Ile Thr Glu Ile Lys Val 
        35                  40                  45              


Asp Tyr Val Val Trp Thr Phe Asn Thr Phe Phe Leu Ala Met Val Lys 
    50                  55                  60                  


Lys Asp Gly Val Thr Ser Gln Ser Ser Asn Lys Glu Arg Ile Val Phe 
65                  70                  75                  80  


Pro Asp Gly Leu Tyr Ser Met Lys Leu Ser Gln Leu Lys Lys Asn Asp 
                85                  90                  95      


Ser Gly Ala Tyr Arg Ala Glu Ile Tyr Ser Thr Ser Ser Gln Ala Ser 
            100                 105                 110         


Leu Ile Gln Glu Tyr Val Leu His Val Tyr Lys His Leu Ser Arg Pro 
        115                 120                 125             


Lys Val Thr Ile Asp Arg Gln Ser Asn Lys Asn Gly Thr Cys Val Ile 
    130                 135                 140                 


Asn Leu Thr Cys Ser Thr Asp Gln Asp Gly Glu Asn Val Thr Tyr Ser 
145                 150                 155                 160 


Trp Lys Ala Val Gly Gln Gly Asp Asn Gln Phe His Asp Gly Ala Thr 
                165                 170                 175     


Leu Ser Ile Ala Trp Arg Ser Gly Glu Lys Asp Gln Ala Leu Thr Cys 
            180                 185                 190         


Met Ala Arg Asn Pro Val Ser Asn Ser Phe Ser Thr Pro Val Phe Pro 
        195                 200                 205             


Gln Lys Leu Cys Glu Asp Ala Ala Thr Asp Leu Thr Ser Leu Arg Gly 
    210                 215                 220                 


Ile Leu Tyr Ile Leu Cys Phe Ser Ala Val Leu Ile Leu Phe Ala Val 
225                 230                 235                 240 


Leu Leu Thr Ile Phe His Thr Thr Trp Ile Lys Lys Gly Lys Gly Cys 
                245                 250                 255     


Glu Glu Asp Lys Lys Arg Val Asp Arg His Gln Glu Met Pro Asp Leu 
            260                 265                 270         


Cys Pro His Leu Glu Glu Asn Ala Asp Tyr Asp Thr Ile Pro Tyr Thr 
        275                 280                 285             


Glu Lys Arg Arg Pro Glu Glu Asp Ala Pro Asn Thr Phe Tyr Ser Thr 
    290                 295                 300                 


Val Gln Ile Pro Lys Val Val Lys Ser Pro Ser Ser Leu Pro Ala Lys 
305                 310                 315                 320 


Pro Leu Val Pro Arg Ser Leu Ser Phe Glu Asn Val Ile 
                325                 330             


<210>  11
<211>  311
<212>  PRT
<213>  Mus musculus

<400>  11

Ser Gly Thr Leu Lys Lys Val Ala Gly Ala Leu Asp Gly Ser Val Thr 
1               5                   10                  15      


Phe Thr Leu Asn Ile Thr Glu Ile Lys Val Asp Tyr Val Val Trp Thr 
            20                  25                  30          


Phe Asn Thr Phe Phe Leu Ala Met Val Lys Lys Asp Gly Val Thr Ser 
        35                  40                  45              


Gln Ser Ser Asn Lys Glu Arg Ile Val Phe Pro Asp Gly Leu Tyr Ser 
    50                  55                  60                  


Met Lys Leu Ser Gln Leu Lys Lys Asn Asp Ser Gly Ala Tyr Arg Ala 
65                  70                  75                  80  


Glu Ile Tyr Ser Thr Ser Ser Gln Ala Ser Leu Ile Gln Glu Tyr Val 
                85                  90                  95      


Leu His Val Tyr Lys His Leu Ser Arg Pro Lys Val Thr Ile Asp Arg 
            100                 105                 110         


Gln Ser Asn Lys Asn Gly Thr Cys Val Ile Asn Leu Thr Cys Ser Thr 
        115                 120                 125             


Asp Gln Asp Gly Glu Asn Val Thr Tyr Ser Trp Lys Ala Val Gly Gln 
    130                 135                 140                 


Gly Asp Asn Gln Phe His Asp Gly Ala Thr Leu Ser Ile Ala Trp Arg 
145                 150                 155                 160 


Ser Gly Glu Lys Asp Gln Ala Leu Thr Cys Met Ala Arg Asn Pro Val 
                165                 170                 175     


Ser Asn Ser Phe Ser Thr Pro Val Phe Pro Gln Lys Leu Cys Glu Asp 
            180                 185                 190         


Ala Ala Thr Asp Leu Thr Ser Leu Arg Gly Ile Leu Tyr Ile Leu Cys 
        195                 200                 205             


Phe Ser Ala Val Leu Ile Leu Phe Ala Val Leu Leu Thr Ile Phe His 
    210                 215                 220                 


Thr Thr Trp Ile Lys Lys Gly Lys Gly Cys Glu Glu Asp Lys Lys Arg 
225                 230                 235                 240 


Val Asp Arg His Gln Glu Met Pro Asp Leu Cys Pro His Leu Glu Glu 
                245                 250                 255     


Asn Ala Asp Tyr Asp Thr Ile Pro Tyr Thr Glu Lys Arg Arg Pro Glu 
            260                 265                 270         


Glu Asp Ala Pro Asn Thr Phe Tyr Ser Thr Val Gln Ile Pro Lys Val 
        275                 280                 285             


Val Lys Ser Pro Ser Ser Leu Pro Ala Lys Pro Leu Val Pro Arg Ser 
    290                 295                 300                 


Leu Ser Phe Glu Asn Val Ile 
305                 310     


<210>  12
<211>  86
<212>  PRT
<213>  Mus musculus

<400>  12

Lys Lys Val Ala Gly Ala Leu Asp Gly Ser Val Thr Phe Thr Leu Asn 
1               5                   10                  15      


Ile Thr Glu Ile Lys Val Asp Tyr Val Val Trp Thr Phe Asn Thr Phe 
            20                  25                  30          


Phe Leu Ala Met Val Lys Lys Asp Gly Val Thr Ser Gln Ser Ser Asn 
        35                  40                  45              


Lys Glu Arg Ile Val Phe Pro Asp Gly Leu Tyr Ser Met Lys Leu Ser 
    50                  55                  60                  


Gln Leu Lys Lys Asn Asp Ser Gly Ala Tyr Arg Ala Glu Ile Tyr Ser 
65                  70                  75                  80  


Thr Ser Ser Gln Ala Ser 
                85      


<210>  13
<211>  76
<212>  PRT
<213>  Mus musculus

<400>  13

Pro Lys Val Thr Ile Asp Arg Gln Ser Asn Lys Asn Gly Thr Cys Val 
1               5                   10                  15      


Ile Asn Leu Thr Cys Ser Thr Asp Gln Asp Gly Glu Asn Val Thr Tyr 
            20                  25                  30          


Ser Trp Lys Ala Val Gly Gln Gly Asp Asn Gln Phe His Asp Gly Ala 
        35                  40                  45              


Thr Leu Ser Ile Ala Trp Arg Ser Gly Glu Lys Asp Gln Ala Leu Thr 
    50                  55                  60                  


Cys Met Ala Arg Asn Pro Val Ser Asn Ser Phe Ser 
65                  70                  75      


<210>  14
<211>  92
<212>  PRT
<213>  Mus musculus

<400>  14

Gly Ala Leu Asp Gly Ser Val Thr Phe Thr Leu Asn Ile Thr Glu Ile 
1               5                   10                  15      


Lys Val Asp Tyr Val Val Trp Thr Phe Asn Thr Phe Phe Leu Ala Met 
            20                  25                  30          


Val Lys Lys Asp Gly Val Thr Ser Gln Ser Ser Asn Lys Glu Arg Ile 
        35                  40                  45              


Val Phe Pro Asp Gly Leu Tyr Ser Met Lys Leu Ser Gln Leu Lys Lys 
    50                  55                  60                  


Asn Asp Ser Gly Ala Tyr Arg Ala Glu Ile Tyr Ser Thr Ser Ser Gln 
65                  70                  75                  80  


Ala Ser Leu Ile Gln Glu Tyr Val Leu His Val Tyr 
                85                  90          


<210>  15
<211>  70
<212>  PRT
<213>  Mus musculus

<400>  15

Arg Pro Lys Val Thr Ile Asp Arg Gln Ser Asn Lys Asn Gly Thr Cys 
1               5                   10                  15      


Val Ile Asn Leu Thr Cys Ser Thr Asp Gln Asp Gly Glu Asn Val Thr 
            20                  25                  30          


Tyr Ser Trp Lys Ala Val Gly Gln Gly Asp Asn Gln Phe His Asp Gly 
        35                  40                  45              


Ala Thr Leu Ser Ile Ala Trp Arg Ser Gly Glu Lys Asp Gln Ala Leu 
    50                  55                  60                  


Thr Cys Met Ala Arg Asn 
65                  70  


<210>  16
<211>  214
<212>  PRT
<213>  Humanize Mouse

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


