                               SEQUENCE LISTING

<110> FLAGSHIP PIONEERING, INC.
 
<120> COMPOSITIONS COMPRISING CIRCULAR POLYRIBONUCLEOTIDES AND USES 
      THEREOF

<130> 29927-802.601

<140> PCT/US2019/043272
<141> 2019-07-24

<150> 62/863,670
<151> 2019-06-19

<150> 62/823,569
<151> 2019-03-25

<150> 62/702,714
<151> 2018-07-24

<160> 60    

<170> PatentIn version 3.5

<210> 1
<211> 90
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
cgggucggca uggcaucucc accuccucgc gguccgaccu gggcauccga aggaggacgc       60

acguccacuc ggauggcuaa gggagagcca                                        90


<210> 2
<211> 88
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
uggccggcau ggucccagcc uccucgcugg cgccggcugg gcaacauucc gaggggaccg       60

uccccucggu aauggcgaau gggaccca                                          88


<210> 3
<211> 96
<212> RNA
<213> Hepatitis delta virus

<400> 3
ggcucaucuc gacaagaggc ggcaguccuc aguacucuua cucuuuucug uaaagaggag       60

acugcuggac ucgccgccca aguucgagca ugagcc                                 96


<210> 4
<211> 74
<212> RNA
<213> Hepatitis delta virus

<400> 4
ggcuagaggc ggcaguccuc aguacucuua cucuuuucug uaaagaggag acugcuggac       60

ucgccgcccg agcc                                                         74


<210> 5
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
acaaaugggg acgagggggg cggggcggcc                                        30


<210> 6
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
cggagagcag agagggagcg                                                   20


<210> 7
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
cggagagcag agagggagcg                                                   20


<210> 8
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
agagagaggg agagag                                                       16


<210> 9
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
tctctctccc tctctc                                                       16


<210> 10
<211> 33
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
gagagagcgc gugugugugu gugguggugc aua                                    33


<210> 11
<211> 72
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
auugccuaua gaacuuauaa cgaacauggu ucuugccuuu uaccagaacc auccgggugu       60

ugucuccaua ga                                                           72


<210> 12
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
gggguaguga uuuuacccug gagau                                             25


<210> 13
<211> 79
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
gugauggcgc cuacgucgaa gaaaggaguc ucaagggaag gagcguauau ggucgaugaa       60

ucggucaugu cgucagggu                                                    79


<210> 14
<211> 77
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
gagucauagg acgcucgcuc uugcgaccau ggggcacggg gagcccacug cauggaucua       60

ucguaucaua gugcggu                                                      77


<210> 15
<211> 79
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
guagcuucca ugagacuuga ucggggucau ggcucuaggc aucggagaag cugacuaacu       60

uggucacguc guaccuggu                                                    79


<210> 16
<211> 77
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
ggacgcguac gaagggcuga uagggcagag cuccaacuau gcguccagcu cgugcagugg       60

aucgggucgu gccuggu                                                      77


<210> 17
<211> 72
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
cuuugucggc cgaacucgcu guuuaacugc ccggcgagau cgcagggugu ugugcuauuc       60

gcgugccgug ug                                                           72


<210> 18
<211> 232
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 18
aatagccggu cuacggccau accacccuga acgcgcccga ucucgucuga ucucggaagc       60

uaagcagggu cgggccuggu uaguacuugg augggagacc gccugggaau accgggugcu      120

guaggcgucg acuugccaug uguauguggg uacgaaggaa ggauugguau gugguauauu      180

cguacccaca uacucugaug auccuucggg aucauucaug gcaacggcta tt              232


<210> 19
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
aatagccg                                                                 8


<210> 20
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
cggctatt                                                                 8


<210> 21
<211> 51
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
ucauaaucaa uuuauuauuu ucuuuuauuu uauucacaua auuuuguuuu u                51


<210> 22
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
auuuuguuuu uaacauuuc                                                    19


<210> 23
<211> 70
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
ucauaaucaa uuuauuauuu ucuuuuauuu uauucacaua auuuuguuuu uauuuuguuu       60

uuaacauuuc                                                              70


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
tacgcctgca actgtgttgt                                                   20


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
tcgatgatct tgtcgtcgtc                                                   20


<210> 26
<211> 133
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
ccguaauacg acucacuaua ggggagcucg guaccgaauu caagguacuc ugugcuuguc       60

gauguguauu gauggcacuu ucgagucaac gaguugacag aacaaguagu caagcuuugc      120

agagaggauc cuu                                                         133


<210> 27
<211> 74
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
gggagaauuc cgaccagaag gguuagcagu cggcaugcgg uacagacaga ccuuuccucu       60

cuccuuccuc uucu                                                         74


<210> 28
<211> 43
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
gggggaucaa uccaagggac ccggaaacgc ucccuuacac ccc                         43


<210> 29
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
aaaaaaaaaa gatcttgaaa ctgttttaag gttggccgat cttaaaaaa                   49


<210> 30
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
aaaaaaattc tccgaacgtg tcacgtttca agagaacgtg acacgttcgg agaaaaaaaa       60


<210> 31
<211> 51
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
ucauaaucaa uuuauuauuu ucuuuuauuu uauucacaua auuuuguuuu u                51


<210> 32
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
cgagacgcta cggacttaaa atccgttgac                                        30


<210> 33
<211> 51
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
ucauaaucaa uuuauuauuu ucuuuuauuu uauucacaua auuuuguuuu u                51


<210> 34
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
auuuuguuuu uaacauuuc                                                    19


<210> 35
<211> 70
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
ucauaaucaa uuuauuauuu ucuuuuauuu uauucacaua auuuuguuuu uauuuuguuu       60

uuaacauuuc                                                              70


<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Gly or His

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Gly or absent

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Val, Ile, Ser or Met

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<400> 36
Xaa Xaa Xaa Glu Xaa Asn Pro Gly Pro 
1               5                   


<210> 37
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Val or Ile

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<400> 37
Asp Xaa Glu Xaa Asn Pro Gly Pro 
1               5               


<210> 38
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   


<210> 39
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Gly Asp Ile Glu Glu Asn Pro Gly Pro 
1               5                   


<210> 40
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Val Glu Pro Asn Pro Gly Pro 
1               5           


<210> 41
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Ile Glu Thr Asn Pro Gly Pro 
1               5           


<210> 42
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Gly Asp Ile Glu Ser Asn Pro Gly Pro 
1               5                   


<210> 43
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gly Asp Val Glu Leu Asn Pro Gly Pro 
1               5                   


<210> 44
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Gly Asp Ile Glu Thr Asn Pro Gly Pro 
1               5                   


<210> 45
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Gly Asp Val Glu Asn Pro Gly Pro 
1               5               


<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   


<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Gly Asp Val Glu Gln Asn Pro Gly Pro 
1               5                   


<210> 48
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Ile Glu Ser Asn Pro Gly Pro 
1               5           


<210> 49
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Gly Asp Ile Glu Leu Asn Pro Gly Pro 
1               5                   


<210> 50
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
His Asp Ile Glu Thr Asn Pro Gly Pro 
1               5                   


<210> 51
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
His Asp Val Glu Thr Asn Pro Gly Pro 
1               5                   


<210> 52
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
His Asp Val Glu Met Asn Pro Gly Pro 
1               5                   


<210> 53
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Gly Asp Met Glu Ser Asn Pro Gly Pro 
1               5                   


<210> 54
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Gly Asp Val Glu Thr Asn Pro Gly Pro 
1               5                   


<210> 55
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Gly Asp Ile Glu Gln Asn Pro Gly Pro 
1               5                   


<210> 56
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Asp Ser Glu Phe Asn Pro Gly Pro 
1               5               


<210> 57
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(35)
<223> This sequence may encompass 6-35 residues

<400> 57
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln 
        35  


<210> 58
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 58
ugugugugug ug                                                           12


<210> 59
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 59
ugukugukug u                                                            11


<210> 60
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 60
auggaauacu cuugguuact t                                                 21
