                         SEQUENCE LISTING

<110>  Pieris Pharmaceuticals GmbH
 
<120>  Humanized anti-PD-1 antibodies and uses thereof

<130>  PIE16249PCT

<150>  EP18185649.3
<151>  2018-07-26

<160>  407   

<170>  PatentIn version 3.5

<210>  1
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  2
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  2

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Lys Ala Leu Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  3

Asp Ile Val Ile Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  4
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  4

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  5
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  5

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  6
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  6

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  7
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  7

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  8
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  9
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  9

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  10
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  10
gaagtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg cttccggcta cacctttacc gactacgaga tgcactgggt gcgacaggcc      120

cctggacagg gcctggaatg gatgggcatc atcgatcctg gcaccggcgg caccgcctac      180

aaccagaaat tccagggcag agtgaccatg accgccgaca agtccacctc caccgtgtac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgcac ctccgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctcgtgac cgtgtcctct      360

gcttctacca agggcccctc cgtgttccct ctggcccctt gctccagatc caccagcgag      420

tctaccgccg ctctgggctg cctcgtgaag gactacttcc ccgagcccgt gacagtgtct      480

tggaactctg gcgccctgac ctccggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ccctgtcctc cgtcgtgact gtgccctcca gctctctggg caccaagacc      600

tacacctgta acgtggacca caagccctcc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc tccttgccca gcccctgagt ttctgggcgg accctctgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cctgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

cgggtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaaa agaccatctc caaggccaag     1020

ggccagcccc gggaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagtcca acggccagcc tgagaacaac tacaagacca ccccccctgt gctggactcc     1200

gacggctcct tcttcctgta ctctcgcctg accgtggaca agtcccggtg gcaggaaggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtctctga gcctgggc                                                   1338


<210>  11
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  11
gaagtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg cttccggcta cacctttacc gactacgaga tgcactgggt gcgacaggcc      120

cctggacagg gcctggaatg gatgggcatc atcgatcctg gcaccggcgg caccgcctac      180

aaccagaaat tccagggcag agtgaccatg accgccgaca agtccaccaa caccgtgtac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgcac ctccgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctcgtgac cgtgtcatct      360

gcttccacca agggcccctc cgtgtttcct ctggcccctt gctccagatc cacctccgag      420

tctaccgccg ctctgggctg cctcgtgaag gactacttcc ccgagcccgt gacagtgtct      480

tggaactctg gcgccctgac ctccggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ccctgtcctc cgtcgtgact gtgccctcca gctctctggg caccaagacc      600

tacacctgta acgtggacca caagccctcc aacaccaagg tggacaagag agtggaatct      660

aagtacggcc ctccctgccc tccttgccca gcccctgagt ttctgggcgg accctctgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cctgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

cgggtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaaa agaccatctc caaggccaag     1020

ggccagcccc gggaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagtcca acggccagcc tgagaacaac tacaagacca ccccccctgt gctggactcc     1200

gacggctcct tcttcctgta ctctcgcctg accgtggaca agtcccggtg gcaggaaggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtctctga gcctgggc                                                   1338


<210>  12
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  12
gaagtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg cttccggcta cacctttacc gactacgaga tgcactgggt gcgacaggcc      120

cctggccaga gactggaatg gatgggcgtg atcgatcctg gcaccggcgg caccgcctac      180

aaccagaaat tccagggcag agtgaccatc accgccgaca agtctgcctc caccgcttac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgcac ctccgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctcgtgac cgtgtcatct      360

gcttccacca agggcccctc cgtgtttcct ctggcccctt gctccagatc cacctccgag      420

tctaccgccg ctctgggctg cctcgtgaag gactacttcc ccgagcccgt gacagtgtct      480

tggaactctg gcgccctgac ctccggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ccctgtcctc cgtcgtgact gtgccctcca gctctctggg caccaagacc      600

tacacctgta acgtggacca caagccctcc aacaccaagg tggacaagag agtggaatct      660

aagtacggcc ctccctgccc cccttgtcct gcccctgaat ttctgggcgg accttccgtg      720

ttcctgttcc ccccaaagcc taaggacacc ctgatgatct cccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

cgggtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaaa agaccatctc caaggccaag     1020

ggccagcccc gggaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagtcca acggccagcc tgagaacaac tataagacca ccccccctgt gctggactcc     1200

gacggcagct tcttcctgta ctctcgcctg accgtggaca agtcccggtg gcaggaaggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtccctgt ctctggga                                                   1338


<210>  13
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  13
gacgtcgtga tgacccagtc ccccctgtct ctgcctgtga ccctgggaca gcctgcctcc       60

atctcctgca gatcctccca gaccatcgtg cactccgacg gcaacaccta cctggaatgg      120

tatcagcagc ggcctggcca gtctccccgg ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc ccgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tcccgggtgg aagccgagga cgtgggcgtg tactactgtt ttcaaggctc ccacgtgccc      300

ctgaccttcg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccctccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca ccgcttctgt cgtgtgcctg      420

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

tccggcaact cccaggaatc cgtgaccgag caggactcca aggacagcac ctactccctg      540

tccagcaccc tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccacc agggcctgtc tagccccgtg accaagtctt tcaaccgggg cgagtgc         657


<210>  14
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  14
gacatcgtga tgacccagtc ccccctgtct ctgcctgtga ccctgggaca gcctgcctcc       60

atctcctgca gatcctccca gaccatcgtg cactccgacg gcaacaccta cctggaatgg      120

tatcagcagc ggcctggcca gtcccctaag ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc ccgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tcccgggtgg aagccgagga cgtgggcgtg tactactgtt ttcaaggctc ccacgtgccc      300

ctgaccttcg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccctccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca ccgcttctgt cgtgtgcctg      420

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

tccggcaact cccaggaatc cgtgaccgag caggactcca aggacagcac ctactccctg      540

tccagcaccc tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccacc agggcctgtc tagccccgtg accaagtctt tcaaccgggg cgagtgc         657


<210>  15
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  15
gacatcgtga tgacccagac ccccctgtcc tcccctgtga cactgggaca gcctgcctcc       60

atctcctgcc ggtcctctca gaccatcgtg cactccgacg gcaacaccta cctggaatgg      120

tatcagcagc ggcctggcca gccccccaga ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc ccgacagatt ctctggatct ggcgctggca ccgacttcac cctgaagatc      240

tctcgggtgg aagccgagga cgtgggcgtg tactactgtt ttcaaggctc ccacgtgccc      300

ctgaccttcg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccctccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca ccgcttctgt cgtgtgcctg      420

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

tccggcaact cccaggaatc cgtgaccgag caggactcca aggacagcac ctactccctg      540

tccagcaccc tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccacc agggcctgtc tagccccgtg accaagtctt tcaaccgggg cgagtgc         657


<210>  16
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  16

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  17
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  17

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  18
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  18

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  19
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  19

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  20
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  21
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  21

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  22
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  22
gaagtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg cttccggcta cacctttacc gactacgaga tgcactgggt gcgacaggcc      120

cctggacagg gcctggaatg gatgggcatc atcgatcctg gcaccggcgg caccgcctac      180

aaccagaaat tccagggcag agtgaccatg accgccgaca agtccacctc caccgtgtac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgcac ctccgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctcgtgac cgtgtcctct      360


<210>  23
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  23
gaagtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg cttccggcta cacctttacc gactacgaga tgcactgggt gcgacaggcc      120

cctggacagg gcctggaatg gatgggcatc atcgatcctg gcaccggcgg caccgcctac      180

aaccagaaat tccagggcag agtgaccatg accgccgaca agtccaccaa caccgtgtac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgcac ctccgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctcgtgac cgtgtcatct      360


<210>  24
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  24
gaagtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg cttccggcta cacctttacc gactacgaga tgcactgggt gcgacaggcc      120

cctggccaga gactggaatg gatgggcgtg atcgatcctg gcaccggcgg caccgcctac      180

aaccagaaat tccagggcag agtgaccatc accgccgaca agtctgcctc caccgcttac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgcac ctccgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctcgtgac cgtgtcatct      360


<210>  25
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  25
gacgtcgtga tgacccagtc ccccctgtct ctgcctgtga ccctgggaca gcctgcctcc       60

atctcctgca gatcctccca gaccatcgtg cactccgacg gcaacaccta cctggaatgg      120

tatcagcagc ggcctggcca gtctccccgg ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc ccgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tcccgggtgg aagccgagga cgtgggcgtg tactactgtt ttcaaggctc ccacgtgccc      300

ctgaccttcg gccagggaac aaagctggaa atcaag                                336


<210>  26
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  26
gacatcgtga tgacccagtc ccccctgtct ctgcctgtga ccctgggaca gcctgcctcc       60

atctcctgca gatcctccca gaccatcgtg cactccgacg gcaacaccta cctggaatgg      120

tatcagcagc ggcctggcca gtcccctaag ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc ccgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tcccgggtgg aagccgagga cgtgggcgtg tactactgtt ttcaaggctc ccacgtgccc      300

ctgaccttcg gccagggaac aaagctggaa atcaag                                336


<210>  27
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  27
gacatcgtga tgacccagac ccccctgtcc tcccctgtga cactgggaca gcctgcctcc       60

atctcctgcc ggtcctctca gaccatcgtg cactccgacg gcaacaccta cctggaatgg      120

tatcagcagc ggcctggcca gccccccaga ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc ccgacagatt ctctggatct ggcgctggca ccgacttcac cctgaagatc      240

tctcgggtgg aagccgagga cgtgggcgtg tactactgtt ttcaaggctc ccacgtgccc      300

ctgaccttcg gccagggaac aaagctggaa atcaag                                336


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR1

<400>  28

Gly Tyr Thr Phe Thr Asp Tyr Glu 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR2

<400>  29

Ile Asp Pro Gly Thr Gly Gly Thr 
1               5               


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR3

<400>  30

Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR1

<400>  31

Gln Thr Ile Val His Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR3

<400>  32

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  33
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  33

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  34
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  34

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  35
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  35

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  36
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  36

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  37
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  37

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  38
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  38

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  39
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  39

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  40
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  40

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  41
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  41

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  42
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  42

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  43
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  43

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  44
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  44

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  45
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  45

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  46
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  46

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  47
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  47

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  48
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  48

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Lys Ser Ser Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  49
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  49

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  50
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  50

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  51
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  51

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  52
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  52

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  53
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  53

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  54
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  54

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  55
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  55

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  56
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  56

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  57
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  57

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  58
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  58

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  59
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  59

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  60
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  60

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Lys Ser Ser Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  61
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  61

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  62
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  62

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  63
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  63

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  64
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  64

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  65
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  65

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  66
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  66

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  67
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  67

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  68
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  68

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  69
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  69

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  70
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  70

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Arg Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Lys Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  71
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  71

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Arg Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  72
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  72

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Arg Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  73
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  73

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Arg Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  74
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  74

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Leu Gln Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  75
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  75

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Leu Gln Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  76
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  76

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Leu Gln Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  77
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  77

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Leu Gln Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  78
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  78

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Gln Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  79
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  79

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  80
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  80

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  81
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  81

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Gln Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  82
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  82

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  83
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  83

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  84
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  84

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  85
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  85

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  86
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  86

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  87
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  87

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  88
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  88

Ala Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  89
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  89

Ala Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  90
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  90

Ala Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  91
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  91

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Ser Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  92
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  92

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Ser Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  93
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  93

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  94
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  94

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Ser Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  95
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  95

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  96
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  96

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Ser Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  97
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  97

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  98
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  98

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  99
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  99

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  100
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  100

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Phe Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  101
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  101

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Phe Ser Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  102
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  102

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Phe Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  103
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  103

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Phe Ser Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  104
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  104

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  105
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  105

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  106
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  106

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  107
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  107

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  108
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  108

Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Arg Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Leu Phe Arg Gly His Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Lys Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  109
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  109

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  110
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  110

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Ala Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  111
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  111

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Arg Phe Val Phe Ser Leu Asp Thr Ser Val Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  112
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  112

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Lys Pro Pro Ala 
1               5                   10                  15      


Thr Val Ser Leu Thr Cys Ala Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Arg Val Thr Ile Ser Ala Asp Lys Ser Lys Asn Thr Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  113
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  113

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Val Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val His Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  114
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  114

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  115
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  115

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  116
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  116

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  117
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  117

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  118
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  118

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Ile Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  119
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  119

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  120
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  120

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  121
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  121

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  122
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  122

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  123
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  123

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  124
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  124

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  125
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  125

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  126
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  126

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  127
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  127

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  128
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  128

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  129
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  129

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  130
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  130

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  131
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  131

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  132
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  132

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  133
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  133

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  134
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  134

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Lys Ser Ser Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  135
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  135

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  136
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  136

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  137
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  137

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  138
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  138

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  139
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  139

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  140
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  140

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  141
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  141

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  142
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  142

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  143
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  143

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  144
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  144

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  145
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  145

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  146
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  146

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Lys Ser Ser Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  147
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  147

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  148
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  148

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  149
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  149

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  150
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  150

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  151
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  151

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  152
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  152

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  153
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  153

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  154
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  154

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Lys Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  155
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  155

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  156
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  156

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Arg Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Lys Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  157
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  157

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Arg Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  158
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  158

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Arg Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  159
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  159

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Arg Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  160
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  160

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Leu Gln Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  161
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  161

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Leu Gln Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  162
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  162

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Leu Gln Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  163
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  163

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Leu Gln Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  164
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  164

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Gln Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  165
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  165

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  166
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  166

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  167
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  167

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Gln Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  168
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  168

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  169
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  169

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  170
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  170

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  171
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  171

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  172
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  172

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  173
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  173

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  174
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  174

Ala Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  175
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  175

Ala Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  176
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  176

Ala Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  177
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  177

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Ser Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  178
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  178

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Ser Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  179
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  179

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  180
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  180

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Ser Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  181
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  181

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  182
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  182

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Ser Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  183
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  183

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  184
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  184

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  185
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  185

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Thr Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  186
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  186

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Phe Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  187
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  187

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Phe Ser Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  188
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  188

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Phe Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  189
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  189

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Phe Ser Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  190
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  190

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  191
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  191

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  192
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  192

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  193
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  193

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  194
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  194

Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Arg Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Leu Phe Arg Gly His Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Lys Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  195
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  195

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  196
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  196

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Ala Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  197
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  197

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Arg Phe Val Phe Ser Leu Asp Thr Ser Val Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  198
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  198

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Lys Pro Pro Ala 
1               5                   10                  15      


Thr Val Ser Leu Thr Cys Ala Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Arg Val Thr Ile Ser Ala Asp Lys Ser Lys Asn Thr Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  199
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  199

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Val Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val His Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  200
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  200

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  201
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  201

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  202
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  202

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  203
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  203

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  204
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  204

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Ile Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  205
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  205
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  206
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  206
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  207
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  207
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccatc atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  208
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  208
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  209
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  209
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca aggccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  210
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  210
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca actccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  211
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  211
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acgcctcgaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  212
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  212
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  213
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  213
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  214
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  214
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccgtt atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  215
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  215
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccatc atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agccgggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  216
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  216
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccatc atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agccgggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  217
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  217
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccgtt atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agccgggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  218
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  218
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccgtt atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agccgggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  219
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  219
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccgtt atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agcgcggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  220
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  220
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccgtt atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agcgcggaca agtcctccaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  221
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  221
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccgtt atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agcgcggaca agtcctccaa caccgcgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttctcgcctg accgtggaca agtccagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  222
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  222
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  223
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  223
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt ccggcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  224
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  224
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat ccggcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  225
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  225
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtctcagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  226
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  226
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  227
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  227
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtctcagtg atcgatcctg gcacaggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  228
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  228
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt ccggcaggcc      120

cctggcaaag gactggaatg ggtctcagtg atcgatcctg gcacaggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  229
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  229
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  230
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  230
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  231
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  231
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa taccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  232
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  232
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc tccgccgaca agtctagcaa taccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  233
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  233
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc tccgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  234
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  234
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  235
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  235
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt ccggcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  236
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  236
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat ccggcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  237
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  237
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtctcagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  238
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  238
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  239
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  239
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtctcagtg atcgatcctg gcacaggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  240
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  240
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt ccggcaggcc      120

cctggcaaag gactggaatg ggtctcagtg atcgatcctg gcacaggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  241
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  241
gaggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcctgcaagg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360

gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag      420

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      480

tggaactccg gtgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      540

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcct ctagcctggg caccaagacc      600

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      660

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaagaggat cccgaagtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa ctccacctac      900

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccttcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagccta gggaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag     1080

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa     1140

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc     1200

gacggctcct tcttcctgta ttcccgcctg accgtggaca agagcagatg gcaagagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtctctgt ccctggga                                                   1338


<210>  242
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  242
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaataccta cctcggctgg      120

tatcagcaga agcccggcaa ggctcctaag ctgctgatct acaaggtgtc cagcctgcag      180

tctggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

agctccctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgtgaa      600

gtgacccacc agggcctgtc tagccctgtg accaagtcct tcaacagagg cgagtgc         657


<210>  243
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  243
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaataccta cctcgaatgg      120

tatcagcaga agcccggcaa ggctcctaag ctgctgatct acaaggtgtc cagcctgcag      180

tctggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

agctccctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgtgaa      600

gtgacccacc agggcctgtc tagccctgtg accaagtcct tcaacagagg cgagtgc         657


<210>  244
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  244
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaataccta cctcggctgg      120

tatcagcaga agcccggcaa ggctcctaag ctgctgatct acaaggtgtc caatctgcag      180

tctggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

agctccctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgtgaa      600

gtgacccacc agggcctgtc tagccctgtg accaagtcct tcaacagagg cgagtgc         657


<210>  245
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  245
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaataccta cctcgaatgg      120

tatcagcaga agcccggcaa ggctcctaag ctgctgatct acaaggtgtc caatctgcag      180

tctggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

agctccctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgtgaa      600

gtgacccacc agggcctgtc tagccctgtg accaagtcct tcaacagagg cgagtgc         657


<210>  246
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  246
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaataccta cctcggctgg      120

tatcagcaga agcccggcaa ggctcctaag ctgctgatct acaaggtgtc caatcggcag      180

tctggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

agctccctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgtgaa      600

gtgacccacc agggcctgtc tagccctgtg accaagtcct tcaacagagg cgagtgc         657


<210>  247
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  247
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  248
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  248
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctgggatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  249
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  249
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc caaccggcag      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  250
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  250
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc caacctgttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  251
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  251
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc ctcccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  252
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  252
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctgggatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc ctcccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  253
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  253
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc ctccctgttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  254
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  254
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctgggatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc ctccctgttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  255
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  255
gccatccaga tgacccagtc accttccagc ctgtctgcct ctgtgggcga cagagtgacc       60

atcacctgtc ggtcctctca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa gtcccctaag ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctatagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagtcccgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  256
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  256
gccatccaga tgacccagac accttccagc ctgtctgcct ctgtgggcga cagagtgacc       60

atcacctgtc gggcctctca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa gtcccctaag ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctatagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagtcccgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  257
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  257
gccatccaga tgacccagac accttccagc ctgtctgcct ctgtgggcga cagagtgacc       60

atcacctgtc ggtcctctca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa gccccctaag ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctatagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagtcccgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  258
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  258
gccatccaga tgacccagac accttccagc ctgtctgcct ctgtgggcga cagagtgacc       60

atcacctgtc ggtcctctca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa gtcccctaag ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctatagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagtcccgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  259
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  259
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggcctgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc ctccagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaccatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaagcgga cagtggccgc tccttccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aggtggacaa tgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  260
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  260
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc ctccagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaccatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaagcgga cagtggccgc tccttccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aggtggacaa tgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  261
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  261
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggcctgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaccatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaagcgga cagtggccgc tccttccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aggtggacaa tgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  262
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  262
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggcctgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc ctccagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaagcgga cagtggccgc tccttccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aggtggacaa tgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  263
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  263
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaccatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaagcgga cagtggccgc tccttccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aggtggacaa tgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  264
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  264
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc ctccagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaagcgga cagtggccgc tccttccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aggtggacaa tgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  265
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  265
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggcctgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaagcgga cagtggccgc tccttccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aggtggacaa tgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  266
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  266
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaagcgga cagtggccgc tccttccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aggtggacaa tgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  267
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  267
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatctgcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaagcgga cagtggccgc tccttccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aggtggacaa tgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  268
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  268
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

ttcggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaagcgga cagtggccgc tccttccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aggtggacaa tgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  269
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  269
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

ttcagcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaagcgga cagtggccgc tccttccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aggtggacaa tgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  270
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  270
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatctgcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

ttcggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaagcgga cagtggccgc tccttccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aggtggacaa tgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  271
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  271
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaacaccta cctggaatgg      120

tatctgcaga agcccggcca ggctcctaga ctgctgatct acaaggtgtc caaccgggcc      180

ttcagcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tctcggctgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaagcgga cagtggccgc tccttccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aggtggacaa tgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  272
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  272
gatgtggtta tgacccagtc tcctctgagc ctgcctgtga cattgggcca gcctgcctcc       60

atctcctgca gatcctctca gaccatcgtg cactccgacg gcaacaccta cctgaactgg      120

ttccagcagc ggcctggcca gagtcctaga cggctgatct acaaggtgtc caacagagac      180

tctggcgtgc ccgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagagtgg aagccgagga cgtgggcgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gcgctggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tccagcacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  273
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  273
gatgtggtta tgacccagtc tcctctgagc ctgcctgtga cattgggcca gcctgcctcc       60

atctcctgca gatcctctca gaccatcgtg cactccgacg gcaacaccta cctggagtgg      120

ttccagcagc ggcctggcca gagtcctaga cggctgatct acaaggtgtc caacagagac      180

tctggcgtgc ccgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagagtgg aagccgagga cgtgggcgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gcgctggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tccagcacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  274
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  274
gatgtggtta tgacccagtc tcctctgagc ctgcctgtga cattgggcca gcctgcctcc       60

atctcctgca gatcctctca gaccatcgtg cactccgacg gcaacaccta cctgaactgg      120

taccagcagc ggcctggcca gagtcctaga cggctgatct acaaggtgtc caacagagac      180

tctggcgtgc ccgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagagtgg aagccgagga cgtgggcgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gcgctggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tccagcacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  275
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  275
gatgtggtta tgacccagtc tcctctgagc ctgcctgtga cattgggcca gcctgcctcc       60

atctcctgca gatcctctca gaccatcgtg cactccgacg gcaacaccta cctggagtgg      120

taccagcagc ggcctggcca gagtcctaga cggctgatct acaaggtgtc caacagagac      180

tctggcgtgc ccgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagagtgg aagccgagga cgtgggcgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gcgctggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tccagcacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  276
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  276
gccatcagga tgacccagtc tccatcctct ctgtccgcct ctgtgggcgg cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccaggaa ggcccctaag ctgctgatct acaaggtgtc ctccctgttc      180

aggggccacc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctga agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaagcgga ccgtggccgc tccttccgtg      360

ttcatctttc caccttccga cgagcagctg aagtccggca cagcttctgt cgtgtgcctg      420

ctgaacaact tctaccctcg ggaagccaag gtgcagtgga aagtggataa cgccctgcag      480

tccggcaact cccaagagtc tgtgaccgag caggactcca aggacagcac ctacagcctg      540

tcctccacac tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccatc agggcctgtc tagccctgtg accaagtctt tcaaccgggg cgagtgt         657


<210>  277
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  277
caagtgcagt tggtgcagag cggagccgag gtcaagaagc cgggcgcttc agtgaaagtg       60

tcctgcaagg cgtccggata caccttcact gactacgaaa tgcactgggt cagacaggcg      120

cccggccaga ggctggagtg gatcggggtc atcgatcctg gaaccggcgg aaccgcctac      180

aaccagaagt tcaaggtccg cgtgaccatt actagggaca ctagcgcgag caccgcttac      240

atggagctgt ctagcctgcg gtccgaggac accgctgtct actactgcac ctccgaaaag      300

tttggttcga actactactt cgattactgg ggccagggga cgctcgtgac cgtcagcagc      360

gcgtccacta agggcccctc cgtctttccg ctggcaccct gctcgcgctc cacttccgaa      420

tctaccgccg ccttgggctg ccttgtgaag gactatttcc cggagcctgt gacagtgtcg      480

tggaacagcg gagccctcac ttccggcgtc cacaccttcc ctgccgtgct gcagtcatcc      540

ggactctatt ccctgtcctc ggtcgtgacc gtgccgtcga gcagcctggg aactaagacc      600

tacacttgca acgtggacca caagccatcc aacaccaaag tggataagcg ggtggagtcc      660

aaatacggtc cgccttgccc cccgtgtcct gcccccgagt tcctgggcgg accctcggtg      720

tttctgttcc cgcccaagcc aaaggatacc ctcatgattt cccggacccc ggaagtcact      780

tgtgtggtgg tggacgtgtc gcaagaggac ccagaagtgc agttcaattg gtacgtggac      840

ggagtcgagg tgcacaatgc aaagaccaag ccacgggaag aacagttcaa ctcaacctac      900

cgcgtggtgt ccgtcctgac tgtgctgcat caggactggc tcaacgggaa ggagtacaag      960

tgcaaagtgt ccaacaaggg tctgccctcc tccatcgaaa agaccatctc caaggccaag     1020

ggacaaccta gagaacctca ggtctacacc ctgccgccga gccaggagga aatgaccaaa     1080

aaccaagtgt cccttacttg cctcgtgaag ggtttctacc cctccgacat tgccgtggag     1140

tgggaatcca atgggcagcc ggagaacaac tacaagacca cacctcctgt gctggattca     1200

gacggcagct tcttcctcta ctcgcgcctt actgtggaca agtcgcggtg gcaggaaggg     1260

aacgtgttct cctgttccgt catgcacgag gccctccaca accactacac ccagaagtcg     1320

ctgtcgctgt cactgggg                                                   1338


<210>  278
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  278
gatattgtga tgactcagac cccgctttcc ctgtccgtga ctccgggcca gcccgcctcc       60

atctcctgcc ggagctcaca gaccatcgtg cactccgacg gcaacaccta cctcgaatgg      120

tatctgcaga agccggggca gagcccgcag ttgctgatct acaaagtgtc caaccggttc      180

tccggagtgc cggataggtt ctcgggctcc gggtccggca cagacttcac cctcaaaatt      240

tcacgcgtgg aagcggacga cgtgggcgtg tactactgct tccaaggatc ccacgtgcct      300

ctcactttcg gacctggtac taaggtcgag atcaagagaa ccgtggcagc tccctccgtg      360

ttcattttcc ccccatcgga cgagcagctg aagtccggaa ccgccagcgt cgtgtgtctg      420

ctgaacaatt tctatcctcg cgaagccaag gtccagtgga aggtcgataa cgccctgcaa      480

agcgggaact cgcaggaatc cgtgactgaa caggactcga aggacagcac ctactcactg      540

tcgtccacct tgaccctgag caaggccgac tacgagaagc acaaagtgta cgcgtgcgaa      600

gtcacgcatc agggactcag ctcccccgtg accaagagct tcaaccgggg agagtgt         657


<210>  279
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  279
gatgtcgtga tgactcagtc cccgctttcc ctgcctgtga ctctgggcca gcccgcctcc       60

atctcctgcc ggagctcaca gaccatcgtg cactccgacg gcaacaccta cctcgaatgg      120

tatcagcagc ggccggggca gagcccgagg ttgctgatct acaaagtgtc caaccggttc      180

tccggagtgc cggataggtt ctcgggctcc gggtccggca cagacttcac cctcaaaatt      240

tcacgcgtgg aagcggagga cgtgggcgtg tactactgct tccaaggatc ccacgtgcct      300

ctcactttcg gagccggtac taagctggag atcaagagaa ccgtggcagc tccctccgtg      360

ttcattttcc ccccatcgga cgagcagctg aagtccggaa ccgccagcgt cgtgtgtctg      420

ctgaacaatt tctatcctcg cgaagccaag gtccagtgga aggtcgataa cgccctgcaa      480

agcgggaact cgcaggaatc cgtgactgaa caggactcga aggacagcac ctactcactg      540

tcgtccacct tgaccctgag caaggccgac tacgagaagc acaaagtgta cgcgtgcgaa      600

gtcacgcatc agggactcag ctcccccgtg accaagagct tcaaccgggg agagtgt         657


<210>  280
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  280
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  281
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  281
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  282
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  282
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccatc atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  283
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  283
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  284
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  284
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca aggccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  285
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  285
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca actccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  286
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  286
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acgcctcgaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  287
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  287
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  288
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  288
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcctat atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  289
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  289
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccgtt atcgatcctg gcaccggcgg caccaactac      180

gccgattctg tgaagggcag attcaccatc agccgggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  290
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  290
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccatc atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agccgggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  291
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  291
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccatc atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agccgggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  292
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  292
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgtcctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccgtt atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agccgggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  293
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  293
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccgtt atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agccgggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  294
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  294
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccgtt atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agcgcggaca agtcctccaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  295
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  295
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccgtt atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agcgcggaca agtcctccaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  296
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  296
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat cagacaggcc      120

cctggcaaag gcctggaatg ggtgtccgtt atcgatcctg gcaccggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc agcgcggaca agtcctccaa caccgcgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  297
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  297
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  298
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  298
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt ccggcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  299
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  299
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat ccggcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  300
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  300
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtctcagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  301
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  301
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  302
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  302
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtctcagtg atcgatcctg gcacaggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  303
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  303
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt ccggcaggcc      120

cctggcaaag gactggaatg ggtctcagtg atcgatcctg gcacaggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  304
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  304
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  305
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  305
cagtgccagg tgcagctgct ggaatctggc ggaggacttg tgaagcctgg cggctctctg       60

agactgtctt gtgccgcttc tggctacacc ttcaccgact acgagatgca ctgggtcaag      120

caggcccctg gcaaaggact ggaatgggtc ggagtgatcg atcctggcac aggcggcacc      180

gcctacaacg attctgtgaa gggcagattc accctgaccg ccgacaagtc tagcaatacc      240

ctctacctgc agatgaactc cctgagagcc gaggacaccg ccgtgtacta ctgcacctct      300

gagaagttcg gctccaacta ctacttcgac tactggggcc agggcaccct ggtcacagtt      360

tcttcc                                                                 366


<210>  306
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  306
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa taccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  307
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  307
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc tccgccgaca agtctagcaa taccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  308
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  308
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc tccgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  309
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  309
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  310
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  310
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt ccggcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  311
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  311
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactggat ccggcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  312
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  312
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtctcagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  313
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  313
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  314
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  314
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtctcagtg atcgatcctg gcacaggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  315
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  315
caggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttctggcta caccttcacc gactacgaga tgcactgggt ccggcaggcc      120

cctggcaaag gactggaatg ggtctcagtg atcgatcctg gcacaggcgg caccgcctac      180

gccgattctg tgaagggcag attcaccatc accgccgaca agtctagcaa ttccctctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  316
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  316
gaggtgcagc tgctggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcctgcaagg cttctggcta caccttcacc gactacgaga tgcactgggt caagcaggcc      120

cctggcaaag gactggaatg ggtcggagtg atcgatcctg gcacaggcgg caccgcctac      180

aacgattctg tgaagggcag attcaccctg accgccgaca agtctagcaa taccgcctac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgcac ctctgagaag      300

ttcggctcca actactactt cgactactgg ggccagggca ccctggtcac agtttcttcc      360


<210>  317
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  317
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaataccta cctcggctgg      120

tatcagcaga agcccggcaa ggctcctaag ctgctgatct acaaggtgtc cagcctgcag      180

tctggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

agctccctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  318
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  318
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaataccta cctcgaatgg      120

tatcagcaga agcccggcaa ggctcctaag ctgctgatct acaaggtgtc cagcctgcag      180

tctggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

agctccctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  319
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  319
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaataccta cctcggctgg      120

tatcagcaga agcccggcaa ggctcctaag ctgctgatct acaaggtgtc caatctgcag      180

tctggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

agctccctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  320
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  320
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaataccta cctcgaatgg      120

tatcagcaga agcccggcaa ggctcctaag ctgctgatct acaaggtgtc caatctgcag      180

tctggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

agctccctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  321
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  321
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaataccta cctcggctgg      120

tatcagcaga agcccggcaa ggctcctaag ctgctgatct acaaggtgtc caatcggcag      180

tctggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

agctccctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  322
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  322
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  323
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  323
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctgggatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  324
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  324
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc caaccggcag      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  325
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  325
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc caacctgttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  326
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  326
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc ctcccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  327
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  327
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctgggatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc ctcccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  328
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  328
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc ctccctgttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  329
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  329
gccatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctgggatgg      120

tatcagcaga agcccggcaa ggcccctaag ctgctgatct acaaggtgtc ctccctgttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  330
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  330
gccatccaga tgacccagtc accttccagc ctgtctgcct ctgtgggcga cagagtgacc       60

atcacctgtc ggtcctctca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa gtcccctaag ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  331
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  331
gccatccaga tgacccagac accttccagc ctgtctgcct ctgtgggcga cagagtgacc       60

atcacctgtc gggcctctca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa gtcccctaag ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  332
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  332
gccatccaga tgacccagac accttccagc ctgtctgcct ctgtgggcga cagagtgacc       60

atcacctgtc ggtcctctca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa gccccctaag ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  333
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  333
gccatccaga tgacccagac accttccagc ctgtctgcct ctgtgggcga cagagtgacc       60

atcacctgtc ggtcctctca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccggcaa gtcccctaag ctgctgatct acaaggtgtc caaccggttc      180

tccggcgtgc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctgc agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  334
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  334
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggcctgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc ctccagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaccatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaag                                336


<210>  335
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  335
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc ctccagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaccatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaag                                336


<210>  336
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  336
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggcctgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaccatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaag                                336


<210>  337
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  337
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggcctgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc ctccagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaag                                336


<210>  338
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  338
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaccatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaag                                336


<210>  339
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  339
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc ctccagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaag                                336


<210>  340
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  340
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggcctgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaag                                336


<210>  341
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  341
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaag                                336


<210>  342
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  342
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatctgcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

acaggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaag                                336


<210>  343
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  343
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

ttcggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaag                                336


<210>  344
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  344
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatcagcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

ttcagcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaag                                336


<210>  345
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  345
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaataccta cctggagtgg      120

tatctgcaga agcccggaca ggctcctcgg ctgctgatct acaaggtgtc caacagagcc      180

ttcggcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagactgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaag                                336


<210>  346
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  346
gagattgtgc tgacccagtc tcctggcaca ctgtctttga gccctggcga gagagctacc       60

ctgtcctgta gagcctctca gaccatcgtg cactccgacg gcaacaccta cctggaatgg      120

tatctgcaga agcccggcca ggctcctaga ctgctgatct acaaggtgtc caaccgggcc      180

ttcagcatcc ctgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tctcggctgg aacccgagga cttcgccgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gacagggcac caagctggaa atcaag                                336


<210>  347
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  347
gatgtggtta tgacccagtc tcctctgagc ctgcctgtga cattgggcca gcctgcctcc       60

atctcctgca gatcctctca gaccatcgtg cactccgacg gcaacaccta cctgaactgg      120

ttccagcagc ggcctggcca gagtcctaga cggctgatct acaaggtgtc caacagagac      180

tctggcgtgc ccgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagagtgg aagccgagga cgtgggcgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gcgctggaac aaagctggaa atcaag                                336


<210>  348
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  348
gatgtggtta tgacccagtc tcctctgagc ctgcctgtga cattgggcca gcctgcctcc       60

atctcctgca gatcctctca gaccatcgtg cactccgacg gcaacaccta cctggagtgg      120

ttccagcagc ggcctggcca gagtcctaga cggctgatct acaaggtgtc caacagagac      180

tctggcgtgc ccgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagagtgg aagccgagga cgtgggcgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gcgctggaac aaagctggaa atcaag                                336


<210>  349
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  349
gatgtggtta tgacccagtc tcctctgagc ctgcctgtga cattgggcca gcctgcctcc       60

atctcctgca gatcctctca gaccatcgtg cactccgacg gcaacaccta cctgaactgg      120

taccagcagc ggcctggcca gagtcctaga cggctgatct acaaggtgtc caacagagac      180

tctggcgtgc ccgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagagtgg aagccgagga cgtgggcgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gcgctggaac aaagctggaa atcaag                                336


<210>  350
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  350
gatgtggtta tgacccagtc tcctctgagc ctgcctgtga cattgggcca gcctgcctcc       60

atctcctgca gatcctctca gaccatcgtg cactccgacg gcaacaccta cctggagtgg      120

taccagcagc ggcctggcca gagtcctaga cggctgatct acaaggtgtc caacagagac      180

tctggcgtgc ccgacagatt ctccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagagtgg aagccgagga cgtgggcgtg tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gcgctggaac aaagctggaa atcaag                                336


<210>  351
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  351
gccatcagga tgacccagtc tccatcctct ctgtccgcct ctgtgggcgg cagagtgacc       60

atcacctgta gagccagcca gaccatcgtg cactctgacg gcaacaccta cctggaatgg      120

tatcagcaga agcccaggaa ggcccctaag ctgctgatct acaaggtgtc ctccctgttc      180

aggggccacc cctctagatt ttccggctct ggctctggca ccgactttac cctgacaatc      240

tccagcctga agcctgagga cttcgccacc tactactgct tccaaggctc tcacgtgccc      300

ctgacctttg gccagggaac aaagctggaa atcaag                                336


<210>  352
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  352
caagtgcagt tggtgcagag cggagccgag gtcaagaagc cgggcgcttc agtgaaagtg       60

tcctgcaagg cgtccggata caccttcact gactacgaaa tgcactgggt cagacaggcg      120

cccggccaga ggctggagtg gatcggggtc atcgatcctg gaaccggcgg aaccgcctac      180

aaccagaagt tcaaggtccg cgtgaccatt actagggaca ctagcgcgag caccgcttac      240

atggagctgt ctagcctgcg gtccgaggac accgctgtct actactgcac ctccgaaaag      300

tttggttcga actactactt cgattactgg ggccagggga cgctcgtgac cgtcagcagc      360


<210>  353
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  353
gatattgtga tgactcagac cccgctttcc ctgtccgtga ctccgggcca gcccgcctcc       60

atctcctgcc ggagctcaca gaccatcgtg cactccgacg gcaacaccta cctcgaatgg      120

tatctgcaga agccggggca gagcccgcag ttgctgatct acaaagtgtc caaccggttc      180

tccggagtgc cggataggtt ctcgggctcc gggtccggca cagacttcac cctcaaaatt      240

tcacgcgtgg aagcggacga cgtgggcgtg tactactgct tccaaggatc ccacgtgcct      300

ctcactttcg gacctggtac taaggtcgag atcaag                                336


<210>  354
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  354
gatgtcgtga tgactcagtc cccgctttcc ctgcctgtga ctctgggcca gcccgcctcc       60

atctcctgcc ggagctcaca gaccatcgtg cactccgacg gcaacaccta cctcgaatgg      120

tatcagcagc ggccggggca gagcccgagg ttgctgatct acaaagtgtc caaccggttc      180

tccggagtgc cggataggtt ctcgggctcc gggtccggca cagacttcac cctcaaaatt      240

tcacgcgtgg aagcggagga cgtgggcgtg tactactgct tccaaggatc ccacgtgcct      300

ctcactttcg gagccggtac taagctggag atcaag                                336


<210>  355
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  355

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu 
1               5                   10                  15  


<210>  356
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  356

Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln Leu Gly Trp Arg 
1               5                   10                  15  


<210>  357
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  357

Val Trp Ala Val Leu Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu 
1               5                   10                  15  


<210>  358
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  358

Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg 
1               5                   10                  15  


<210>  359
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  359

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro 
1               5                   10                  15  


<210>  360
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  360

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15  


<210>  361
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  361

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr 
1               5                   10                  15  


<210>  362
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  362

Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15  


<210>  363
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  363

Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
1               5                   10                  15  


<210>  364
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  364

Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser 
1               5                   10                  15  


<210>  365
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  365

Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu 
1               5                   10                  15  


<210>  366
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  366

Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met 
1               5                   10                  15  


<210>  367
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  367

Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln 
1               5                   10                  15  


<210>  368
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  368

Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
1               5                   10                  15  


<210>  369
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  369

Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp 
1               5                   10                  15  


<210>  370
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  370

Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly 
1               5                   10                  15  


<210>  371
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  371

Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
1               5                   10                  15  


<210>  372
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  372

Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
1               5                   10                  15  


<210>  373
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  373

Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
1               5                   10                  15  


<210>  374
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  374

Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
1               5                   10                  15  


<210>  375
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  375

Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg 
1               5                   10                  15  


<210>  376
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  376

Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
1               5                   10                  15  


<210>  377
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  377

Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala 
1               5                   10                  15  


<210>  378
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  378

Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
1               5                   10                  15  


<210>  379
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  379

Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
1               5                   10                  15  


<210>  380
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  380

Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala 
1               5                   10                  15  


<210>  381
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  381

Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
1               5                   10                  15  


<210>  382
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  382

Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu 
1               5                   10                  15  


<210>  383
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  383

Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His 
1               5                   10                  15  


<210>  384
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  384

Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
1               5                   10                  15  


<210>  385
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  385

Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe 
1               5                   10                  15      


<210>  386
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  386

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly 
        435                 


<210>  387
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  387

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  388
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  388

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  389
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  389

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  390
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  390

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Arg Gly Ser Thr Asn Ser Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Leu Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Phe Gly Tyr Ser Asp Tyr Glu Tyr Asn Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  391
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  391

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Asn Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  392
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  392

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  393
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  393

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  394
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  394

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Pro Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Cys Cys 
                85                  90                  95      


Ala Arg 
        


<210>  395
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  395

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  396
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  396

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  397
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  397

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Ser Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ile His Leu Pro 
            100 


<210>  398
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  398

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro 
            100 


<210>  399
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  399

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro 
            100     


<210>  400
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  400

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro 
                85                  90                  95  


<210>  401
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  401

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys 
                85              


<210>  402
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  402

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


<210>  403
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  403

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  404
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  404

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  405
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  405

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Arg Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Ala Lys Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  406
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  406

Asp Ile Val Met Thr Gln His Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Arg Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  407
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  407

Asp Ile Val Met Thr Gln His Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Arg Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


