                         SEQUENCE LISTING

<110>  Administracin General de la Comunidad Autnoma de Euskadi.
 
<120>  BIOMARKERS FOR THE DIAGNOSIS AND/OR PROGNOSIS OF FRAILTY

<130>  PCT3347.5

<150>  EP18382566
<151>  2018-07-27

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  3136
<212>  DNA
<213>  Homo sapiens

<400>  1
gcgcagaact tggggagccg ccgccgccat ccgccgccgc agccagcttc cgccgccgca       60

ggaccggccc ctgccccagc ctccgcagcc gcggcgcgtc cacgcccgcc cgcgcccagg      120

gcgagtcggg gtcgccgcct gcacgcttct cagtgttccc cgcgccccgc atgtaacccg      180

gccaggcccc cgcaactgtg tcccctgcag ctccagcccc gggctgcacc cccccgcccc      240

gacaccagct ctccagcctg ctcgtccagg atggccgcgg ccaaggccga gatgcagctg      300

atgtccccgc tgcagatctc tgacccgttc ggatcctttc ctcactcgcc caccatggac      360

aactacccta agctggagga gatgatgctg ctgagcaacg gggctcccca gttcctcggc      420

gccgccgggg ccccagaggg cagcggcagc aacagcagca gcagcagcag cgggggcggt      480

ggaggcggcg ggggcggcag caacagcagc agcagcagca gcaccttcaa ccctcaggcg      540

gacacgggcg agcagcccta cgagcacctg accgcagagt cttttcctga catctctctg      600

aacaacgaga aggtgctggt ggagaccagt taccccagcc aaaccactcg actgcccccc      660

atcacctata ctggccgctt ttccctggag cctgcaccca acagtggcaa caccttgtgg      720

cccgagcccc tcttcagctt ggtcagtggc ctagtgagca tgaccaaccc accggcctcc      780

tcgtcctcag caccatctcc agcggcctcc tccgcctccg cctcccagag cccacccctg      840

agctgcgcag tgccatccaa cgacagcagt cccatttact cagcggcacc caccttcccc      900

acgccgaaca ctgacatttt ccctgagcca caaagccagg ccttcccggg ctcggcaggg      960

acagcgctcc agtacccgcc tcctgcctac cctgccgcca agggtggctt ccaggttccc     1020

atgatccccg actacctgtt tccacagcag cagggggatc tgggcctggg caccccagac     1080

cagaagccct tccagggcct ggagagccgc acccagcagc cttcgctaac ccctctgtct     1140

actattaagg cctttgccac tcagtcgggc tcccaggacc tgaaggccct caataccagc     1200

taccagtccc agctcatcaa acccagccgc atgcgcaagt accccaaccg gcccagcaag     1260

acgccccccc acgaacgccc ttacgcttgc ccagtggagt cctgtgatcg ccgcttctcc     1320

cgctccgacg agctcacccg ccacatccgc atccacacag gccagaagcc cttccagtgc     1380

cgcatctgca tgcgcaactt cagccgcagc gaccacctca ccacccacat ccgcacccac     1440

acaggcgaaa agcccttcgc ctgcgacatc tgtggaagaa agtttgccag gagcgatgaa     1500

cgcaagaggc ataccaagat ccacttgcgg cagaaggaca agaaagcaga caaaagtgtt     1560

gtggcctctt cggccacctc ctctctctct tcctacccgt ccccggttgc tacctcttac     1620

ccgtccccgg ttactacctc ttatccatcc ccggccacca cctcataccc atcccctgtg     1680

cccacctcct tctcctctcc cggctcctcg acctacccat cccctgtgca cagtggcttc     1740

ccctccccgt cggtggccac cacgtactcc tctgttcccc ctgctttccc ggcccaggtc     1800

agcagcttcc cttcctcagc tgtcaccaac tccttcagcg cctccacagg gctttcggac     1860

atgacagcaa ccttttctcc caggacaatt gaaatttgct aaagggaaag gggaaagaaa     1920

gggaaaaggg agaaaaagaa acacaagaga cttaaaggac aggaggagga gatggccata     1980

ggagaggagg gttcctctta ggtcagatgg aggttctcag agccaagtcc tccctctcta     2040

ctggagtgga aggtctattg gccaacaatc ctttctgccc acttcccctt ccccaattac     2100

tattcccttt gacttcagct gcctgaaaca gccatgtcca agttcttcac ctctatccaa     2160

agaacttgat ttgcatggat tttggataaa tcatttcagt atcatctcca tcatatgcct     2220

gaccccttgc tcccttcaat gctagaaaat cgagttggca aaatggggtt tgggcccctc     2280

agagccctgc cctgcaccct tgtacagtgt ctgtgccatg gatttcgttt ttcttggggt     2340

actcttgatg tgaagataat ttgcatattc tattgtatta tttggagtta ggtcctcact     2400

tgggggaaaa aaaaaaaaga aaagccaagc aaaccaatgg tgatcctcta ttttgtgatg     2460

atgctgtgac aataagtttg aacctttttt tttgaaacag cagtcccagt attctcagag     2520

catgtgtcag agtgttgttc cgttaacctt tttgtaaata ctgcttgacc gtactctcac     2580

atgtggcaaa atatggtttg gtttttcttt tttttttttt ttgaaagtgt tttttcttcg     2640

tccttttggt ttaaaaagtt tcacgtcttg gtgccttttg tgtgatgcgc cttgctgatg     2700

gcttgacatg tgcaattgtg agggacatgc tcacctctag ccttaagggg ggcagggagt     2760

gatgatttgg gggaggcttt gggagcaaaa taaggaagag ggctgagctg agcttcggtt     2820

ctccagaatg taagaaaaca aaatctaaaa caaaatctga actctcaaaa gtctattttt     2880

ttaactgaaa atgtaaattt ataaatatat tcaggagttg gaatgttgta gttacctact     2940

gagtaggcgg cgatttttgt atgttatgaa catgcagttc attattttgt ggttctattt     3000

tactttgtac ttgtgtttgc ttaaacaaag tgactgtttg gcttataaac acattgaatg     3060

cgctttattg cccatgggat atgtggtgta tatccttcca aaaaattaaa acgaaaataa     3120

agtagctgcg attggg                                                     3136


<210>  2
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Ala Lys Ala Glu Met Gln Leu Met Ser Pro Leu Gln Ile 
1               5                   10                  15      


Ser Asp Pro Phe Gly Ser Phe Pro His Ser Pro Thr Met Asp Asn Tyr 
            20                  25                  30          


Pro Lys Leu Glu Glu Met Met Leu Leu Ser Asn Gly Ala Pro Gln Phe 
        35                  40                  45              


Leu Gly Ala Ala Gly Ala Pro Glu Gly Ser Gly Ser Asn Ser Ser Ser 
    50                  55                  60                  


Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Asn Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Thr Phe Asn Pro Gln Ala Asp Thr Gly Glu Gln Pro 
                85                  90                  95      


Tyr Glu His Leu Thr Ala Glu Ser Phe Pro Asp Ile Ser Leu Asn Asn 
            100                 105                 110         


Glu Lys Val Leu Val Glu Thr Ser Tyr Pro Ser Gln Thr Thr Arg Leu 
        115                 120                 125             


Pro Pro Ile Thr Tyr Thr Gly Arg Phe Ser Leu Glu Pro Ala Pro Asn 
    130                 135                 140                 


Ser Gly Asn Thr Leu Trp Pro Glu Pro Leu Phe Ser Leu Val Ser Gly 
145                 150                 155                 160 


Leu Val Ser Met Thr Asn Pro Pro Ala Ser Ser Ser Ser Ala Pro Ser 
                165                 170                 175     


Pro Ala Ala Ser Ser Ala Ser Ala Ser Gln Ser Pro Pro Leu Ser Cys 
            180                 185                 190         


Ala Val Pro Ser Asn Asp Ser Ser Pro Ile Tyr Ser Ala Ala Pro Thr 
        195                 200                 205             


Phe Pro Thr Pro Asn Thr Asp Ile Phe Pro Glu Pro Gln Ser Gln Ala 
    210                 215                 220                 


Phe Pro Gly Ser Ala Gly Thr Ala Leu Gln Tyr Pro Pro Pro Ala Tyr 
225                 230                 235                 240 


Pro Ala Ala Lys Gly Gly Phe Gln Val Pro Met Ile Pro Asp Tyr Leu 
                245                 250                 255     


Phe Pro Gln Gln Gln Gly Asp Leu Gly Leu Gly Thr Pro Asp Gln Lys 
            260                 265                 270         


Pro Phe Gln Gly Leu Glu Ser Arg Thr Gln Gln Pro Ser Leu Thr Pro 
        275                 280                 285             


Leu Ser Thr Ile Lys Ala Phe Ala Thr Gln Ser Gly Ser Gln Asp Leu 
    290                 295                 300                 


Lys Ala Leu Asn Thr Ser Tyr Gln Ser Gln Leu Ile Lys Pro Ser Arg 
305                 310                 315                 320 


Met Arg Lys Tyr Pro Asn Arg Pro Ser Lys Thr Pro Pro His Glu Arg 
                325                 330                 335     


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            340                 345                 350         


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        355                 360                 365             


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    370                 375                 380                 


Thr His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile 
385                 390                 395                 400 


Cys Gly Arg Lys Phe Ala Arg Ser Asp Glu Arg Lys Arg His Thr Lys 
                405                 410                 415     


Ile His Leu Arg Gln Lys Asp Lys Lys Ala Asp Lys Ser Val Val Ala 
            420                 425                 430         


Ser Ser Ala Thr Ser Ser Leu Ser Ser Tyr Pro Ser Pro Val Ala Thr 
        435                 440                 445             


Ser Tyr Pro Ser Pro Val Thr Thr Ser Tyr Pro Ser Pro Ala Thr Thr 
    450                 455                 460                 


Ser Tyr Pro Ser Pro Val Pro Thr Ser Phe Ser Ser Pro Gly Ser Ser 
465                 470                 475                 480 


Thr Tyr Pro Ser Pro Val His Ser Gly Phe Pro Ser Pro Ser Val Ala 
                485                 490                 495     


Thr Thr Tyr Ser Ser Val Pro Pro Ala Phe Pro Ala Gln Val Ser Ser 
            500                 505                 510         


Phe Pro Ser Ser Ala Val Thr Asn Ser Phe Ser Ala Ser Thr Gly Leu 
        515                 520                 525             


Ser Asp Met Thr Ala Thr Phe Ser Pro Arg Thr Ile Glu Ile Cys 
    530                 535                 540             


<210>  3
<211>  1652
<212>  DNA
<213>  Homo sapiens

<400>  3
cttgccgtca gccttttctt tgacctcttc tttctgttca tgtgtatttg ctgtctctta       60

gcccagactt cccgtgtcct ttccaccggg cctttgagag gtcacagggt cttgatgctg      120

tggtcttcat ctgcaggtgt ctgacttcca gcaactgctg gcctgtgcca gggtgcaagc      180

tgagcactgg agtggagttt tcctgtggag aggagccatg cctagagtgg gatgggccat      240

tgttcatctt ctggcccctg ttgtctgcat gtaacttaat accacaacca ggcatagggg      300

aaagattgga ggaaagatga gtgagagcat caacttctct cacaacctag gccagtgtgt      360

ggtgatgcca ggcatgccct tccccagcat caggtctcca gagctgcaga agacgacggc      420

cgacttggat cacactcttg tgagtgtccc cagtgttgca gaggcagggc catcaggcac      480

caaagggatt ctgccagcat agtgctcctg gaccagtgat acacccggca ccctgtcctg      540

gacacgctgt tggcctggat ctgagccctg gtggaggtca aagccacctt tggttctgcc      600

attgctgctg tgtggaagtt cactcctgcc ttttcctttc cctagagcct ccaccacccc      660

gagatcacat ttctcactgc cttttgtctg cccagtttca ccagaagtag gcctcttcct      720

gacaggcagc tgcaccactg cctggcgctg tgcccttcct ttgctctgcc cgctggagac      780

ggtgtttgtc atgggcctgg tctgcaggga tcctgctaca aaggtgaaac ccaggagagt      840

gtggagtcca gagtgttgcc aggacccagg cacaggcatt agtgcccgtt ggagaaaaca      900

ggggaatccc gaagaaatgg tgggtcctgg ccatccgtga gatcttccca gggcagctcc      960

cctctgtgga atccaatctg tcttccatcc tgcgtggccg agggccaggc ttctcactgg     1020

gcctctgcag gaggctgcca tttgtcctgc ccaccttctt agaagcgaga cggagcagac     1080

ccatctgcta ctgccctttc tataataact aaagttagct gccctggact attcaccccc     1140

tagtctcaat ttaagaagat ccccatggcc acagggcccc tgcctggggg cttgtcacct     1200

cccccacctt cttcctgagt cattcctgca gccttgctcc ctaacctgcc ccacagcctt     1260

gcctggattt ctatctccct ggcttggtgc cagttcctcc aagtcgatgg cacctccctc     1320

cctctcaacc acttgagcaa actccaagac atcttctacc ccaacaccag caattgtgcc     1380

aagggccatt aggctctcag catgactatt tttagagacc ccgtgtctgt cactgaaacc     1440

ttttttgtgg gagactattc ctcccatctg caacagctgc ccctgctgac tgcccttctc     1500

tcctccctct catcccagag aaacaggtca gctgggagct tctgccccca ctgcctaggg     1560

accaacaggg gcaggaggca gtcactgacc ccgagacgtt tgcatcctgc acagctagag     1620

atcctttatt aaaagcacac tgttggtttc tg                                   1652


<210>  4
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Ile Phe Arg Asp Pro Val Ser Val Thr Glu Thr Phe Phe Val 
1               5                   10                  15      


Gly Asp Tyr Ser Ser His Leu Gln Gln Leu Pro Leu Leu Thr Ala Leu 
            20                  25                  30          


Leu Ser Ser Leu Ser Ser Gln Arg Asn Arg Ser Ala Gly Ser Phe Cys 
        35                  40                  45              


Pro His Cys Leu Gly Thr Asn Arg Gly Arg Arg Gln Ser Leu Thr Pro 
    50                  55                  60                  


Arg Arg Leu His Pro Ala Gln Leu Glu Ile Leu Tyr 
65                  70                  75      


<210>  5
<211>  115
<212>  DNA
<213>  Homo sapiens

<400>  5
tctgtttatc accagatcct agaaccctat caatattgtc tctgctgtgt aaatagttct       60

gagtagtgca atattgctta tagggttttg gtgtttggaa agaacaatgg gcagg           115


<210>  6
<211>  2285
<212>  DNA
<213>  Homo sapiens

<400>  6
cccgctcgtc tggcccgccc ccctcgccct cgcaggcggt ccgcgccact gcctctcagt       60

ccctgtcctg cgcccgcgcg ccccgggagc ctacccagca cgcgctccgc gcccactggt      120

tccctccagc cgccgccgtc cagccgagtc cccactccgg agtcgccgct gccgcgggga      180

catggtcctc tgcgttcagg ggtgagcacc cccttgtaag ctcagggcta ctgttgggtg      240

tcagggaaca aagttttaga ctgctgcgct ccaaagcggg cacacacatg tacctagaac      300

acaccagcca ctgtccccac catgatgatg acacagccat ggacacaccc ctgcccagac      360

ctcgtccttt gctggctgtg gagcggactg ggcagcggcc cctgtgggcc ccgtccctgg      420

aactgcccaa gccagtcatg cagcccttgc ctgctggggc cttcctcgag gaggtggcag      480

agggtacccc agcccagaca gagagtgagc caaaggtgct ggacccagag gaggatctgc      540

tgtgcatagc caagaccttc tcctaccttc gggaatctgg ctggtattgg ggttccatta      600

cggccagcga ggcccgacaa cacctgcaga agatgccaga aggcacgttc ttagtacgtg      660

acagcacgca ccccagctac ctgttcacgc tgtcagtgaa aaccactcgt ggccccacca      720

atgtacgcat tgagtatgcc gactccagct tccgtctgga ctccaactgc ttgtccaggc      780

cacgcatcct ggcctttccg gatgtggtca gccttgtgca gcactatgtg gcctcctgca      840

ctgctgatac ccgaagcgac agccccgatc ctgctcccac cccggccctg cctatgccta      900

aggaggatgc gcctagtgac ccagcactgc ctgctcctcc accagccact gctgtacacc      960

taaaactggt gcagcccttt gtacgcagaa gcagtgcccg cagcctgcaa cacctgtgcc     1020

gccttgtcat caaccgtctg gtggccgacg tggactgcct gccactgccc cggcgcatgg     1080

ccgactacct ccgacagtac cccttccagc tctgactgta cggggcaatc tgcccaccct     1140

cacccagtcg caccctggag gggacatcag ccccagctgg acttgggccc ccactgtccc     1200

tcctccaggc atcctggtgc ctgcatacct ctggcagctg gcccaggaag agccagcaag     1260

agcaaggcat gggagagggg aggtgtcaca caacttggag gtaaatgccc ccaggccgca     1320

tgtggcttca ttatactgag ccatgtgtca gaggatgggg agacaggcag gaccttgtct     1380

cacctgtggg ctgggcccag acctccactc gcttgcctgc cctggccacc tgaactgtat     1440

gggcactctc agccctggtt tttcaatccc cagggtcggg taggacccct actggcagcc     1500

agcctctgtt tctgggagga tgacatgcag aggaactgag atcgacagtg actagtgacc     1560

ccttgttgag gggtaagcca ggctagggga ctgcacaatt atacactatt tatttattta     1620

ttctccttgg ggttggtgtc aggggcgagc caaccccacc tctatgccct gagccctggt     1680

agtccagaga ccccaactct gccctggctt ctctggttct tccctgtgga aagcccatcc     1740

tgagacatct tgctggaacc aaggcaatcc tggatgtcct ggtactgacc cacccgtctg     1800

tgaatgtgtc cactctcttc tgcccccagc catatttggg gaggatggac aactacaata     1860

ggtaagaaaa tgcagccgga gcctcagtcc ccagcagagc ctgtgtctca ccccctcaca     1920

ggacagagct gtatctgcat agagctggtc tcactgtggc gcaggccccg gggggagtgc     1980

ctgtgctgtc aggaagaggg ggtgctggtt tgagggccgc cactgcagtt ctgctaggtc     2040

tgcttcctgc ccaggaaggt gcctgcacat gagaggagag aaatacacgt ctgataagac     2100

ttcatgaaat aataattata gcaaagaaca gtttggtggt cttttctctt ccactgattt     2160

ttctgtaatg acattatacc tttattacct ctttatttta ttacctctat aataaaatga     2220

tacctttcat gtacagagcc ctcaatgggg ccgattttca gttgtgtaaa aaaaaaaaaa     2280

aaaaa                                                                 2285


<210>  7
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Leu Cys Val Gln Gly Pro Arg Pro Leu Leu Ala Val Glu Arg 
1               5                   10                  15      


Thr Gly Gln Arg Pro Leu Trp Ala Pro Ser Leu Glu Leu Pro Lys Pro 
            20                  25                  30          


Val Met Gln Pro Leu Pro Ala Gly Ala Phe Leu Glu Glu Val Ala Glu 
        35                  40                  45              


Gly Thr Pro Ala Gln Thr Glu Ser Glu Pro Lys Val Leu Asp Pro Glu 
    50                  55                  60                  


Glu Asp Leu Leu Cys Ile Ala Lys Thr Phe Ser Tyr Leu Arg Glu Ser 
65                  70                  75                  80  


Gly Trp Tyr Trp Gly Ser Ile Thr Ala Ser Glu Ala Arg Gln His Leu 
                85                  90                  95      


Gln Lys Met Pro Glu Gly Thr Phe Leu Val Arg Asp Ser Thr His Pro 
            100                 105                 110         


Ser Tyr Leu Phe Thr Leu Ser Val Lys Thr Thr Arg Gly Pro Thr Asn 
        115                 120                 125             


Val Arg Ile Glu Tyr Ala Asp Ser Ser Phe Arg Leu Asp Ser Asn Cys 
    130                 135                 140                 


Leu Ser Arg Pro Arg Ile Leu Ala Phe Pro Asp Val Val Ser Leu Val 
145                 150                 155                 160 


Gln His Tyr Val Ala Ser Cys Thr Ala Asp Thr Arg Ser Asp Ser Pro 
                165                 170                 175     


Asp Pro Ala Pro Thr Pro Ala Leu Pro Met Pro Lys Glu Asp Ala Pro 
            180                 185                 190         


Ser Asp Pro Ala Leu Pro Ala Pro Pro Pro Ala Thr Ala Val His Leu 
        195                 200                 205             


Lys Leu Val Gln Pro Phe Val Arg Arg Ser Ser Ala Arg Ser Leu Gln 
    210                 215                 220                 


His Leu Cys Arg Leu Val Ile Asn Arg Leu Val Ala Asp Val Asp Cys 
225                 230                 235                 240 


Leu Pro Leu Pro Arg Arg Met Ala Asp Tyr Leu Arg Gln Tyr Pro Phe 
                245                 250                 255     


Gln Leu 
        


<210>  8
<211>  1652
<212>  DNA
<213>  Homo sapiens

<400>  8
cttgccgtca gccttttctt tgacctcttc tttctcttca tgtgtatttg ctgtctctta       60

gcccagactt cccgtgtcct ttccaccggg cctttgagag gtcacagggt cttgatgctg      120

tggtcttgat ctgcaggtgt ctgacttcca gcaactgctg gcctgtgcca gggtgcaagc      180

tgagcactgg agtggagttt tcctgtggag aggagccatg cctagagtgg gatgggccat      240

tgttcatctt ctggcccctg ttgtctgcat gtaacttaat accacaacca ggcatacggg      300

aaagattgga ggaaagatga gtgagagcat caacttctct gacaacctag gccagtgtgt      360

ggtgatgcca ggcatgccct tccccagcat caggtctcca gagctgcaga agacgacggc      420

cgacttggat cacactcttg tgagtgtccc cagtgttgca gaggcagggc catcaggcac      480

caaagggatt ctgccagcat agtgctcctg gaccagtgat acacccggca ccctgtcctg      540

gacaggctgt tggcctgaat ctgagccctc gtggaggtca aagcaacctt tggttctgcc      600

attgctgctg tgtggaagtt cactcctgcc ttttcctttc cctagagcct ccaccacccc      660

gagatcacat ttctcactgc cttttgtctg cccagtttca ccagaagtag gcctcttcct      720

gacaggcagc tgcaccactg cctggcgctg cgcccttcct ttgctctgcc cgctggagac      780

ggtgtttgtc atgggcctgg tctgcaggga tcctgctaca aaggtgaaac ccaggagagt      840

gtggaatcca gagtgttgcc aggacccagg cacaggcatt agtgcccgtt ggagaaaaca      900

ggggaatccc gaagaaatgg tgggtcctgg ccatccgtga gatcttccca gggcagctcc      960

cctctgtgga atccaatctg tcttccatcc tgcgtggccg agggccaggc ttctcactgg     1020

gcctctgcag gaggctgcca tttgtcctgc ccaccttctt agaagcgaga cggagcagac     1080

ccatctgcta ctgccctttc tataataact aaagttagct gccctggact attcaccccc     1140

tagtctccat ttaaaaagat ccccatggcc acagggcccc tgcctggggg cttgtcacct     1200

cccccacctt cttcctgagt cactcctgca gccttgctcc ctaacctgcc ccacagcctt     1260

gcctggattt ctatctccct ggcttggtgc cagttcctcc aagtcgatgg cacctccctc     1320

cctctcaacc acgtgagcaa actccaagac atcttctacc ccaacaccag caattgtgcc     1380

aagggccatt aggctctcag catgactatt tttagagacc ccgtgtctgt cactgaaacc     1440

ttttttgtgg gagactattc ctcccatctg caacagctgc ccctgctgac tgcccttctc     1500

tcctccctct catcccagag aaacaggtca gctgggagct tctgccccca ctgcctaggg     1560

accaacaggg gcaggaggca gtcactgacc ccgagacgtt tgcatcctgc acagctagag     1620

gtcctttatt aaaagcacac tgttggtttc tg                                   1652


<210>  9
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Ile Phe Arg Asp Pro Val Ser Val Thr Glu Thr Phe Phe Val 
1               5                   10                  15      


Gly Asp Tyr Ser Ser His Leu Gln Gln Leu Pro Leu Leu Thr Ala Leu 
            20                  25                  30          


Leu Ser Ser Leu Ser Ser Gln Arg Asn Arg Ser Ala Gly Ser Phe Cys 
        35                  40                  45              


Pro His Cys Leu Gly Thr Asn Arg Gly Arg Arg Gln Ser Leu Thr Pro 
    50                  55                  60                  


Arg Arg Leu His Pro Ala Gln Leu Glu Val Leu Tyr 
65                  70                  75      


<210>  10
<211>  3975
<212>  DNA
<213>  Homo sapiens

<400>  10
aagggacatg aagagaataa agaaagaaag aagaaaagaa aagaaaaaag aaaagaaaag       60

ggagggctct gcgggtggcg gcggcgcggg gagccggttg caggccgaga tgctgcagat      120

ggacctgatc gacgcgacgg gggacactcc cggggccgag gacgacgagg aggacgacga      180

cgaggagcgc gcggcccggc ggccgggagc ggggccgccc aaggccgagt ccggccagga      240

gccggcgtcc cgcggccagg gccagagcca aggccagagc cagggcccgg gcagcgggga      300

cacgtaccgg cccaagcggc ccaccacgct caacctcttt ccgcaggtgc agttgtctca      360

ggacacactg aataataatt ctctgggcaa aaagtacagt tggcaggatc gggtgtctcg      420

atcatcctca cccctgaaga caggggagca gacaccaccg catgaaccca tttgcctgag      480

cgatgagctg cccccccaga gcagccccgc ccccaccaca gatcgaggca cctccaccaa      540

cagcccacgc tgctggtaga tgagcacgcg cagctggagc tggtgagcct gcggccgtgc      600

ttcggagact acagtgacga gagtgactcg gccatcgtct acgacaactg tgtctccgtc      660

tcctcgccct atgagtcagc catcggagag gaatatgagg aggcctcccg gccccagcct      720

cctgcctgcc tctccaagga ctccacgcct gacgaacccg acgtccattt ctccaagaag      780

ttcctgaaca tcttcatgag tggccgctcc cgctcctcca gtgccgagtc cttcgggctg      840

ttctcctgca tcatcaaccg ggaggagcag gagcagaccc accggaccat attcaggttt      900

gtgcctcgac acgaagacga acctgagctg gaagtggatg accctctgct agtggagctc      960

caggctgaag actactggta cgaggcctac aacatgcgca ctggtgcccg gggcttcttt     1020

actgcctatt acgccatcga agtcaccaag gagcccgagc acatggcagc cctggctaaa     1080

aacagtgact gggtggacca gttccgggtg aagttcctgg gctcagtcca ggttccctat     1140

cacaagggcg atgtcgtcct ctctgccgct atgcaaaaga ttgccaccac ccgccggcta     1200

accgtgcact ttaacccgcc ctccagctgt gtcctggaga tcagcgtgcg gggtgtgaag     1260

ataggtgtca aggccgatga ctcccaggag gccaagggga ataaatgtag ccactttttc     1320

cagttaaaaa acatctcttt ccgcggatat catccaaaga acaacaagta ctttgggttc     1380

atcaccaagc acctcgccga ccaccggttt gcctgccacg tctttgtgtc tgaagactcc     1440

accaaagccc tggcagagtc cgtggggaga gcattccagc agtttcacaa gcagtttgtg     1500

gagtacacct gccccacaga agatatctac ctggagtagc cgcgcagccc cgccctctgc     1560

gtcccccggc cctcaggcca gtgccaggac agctggctgc tgacaggatg tggcactgct     1620

tgaggagggg cacctgccac cgccagggga tgaggaagtg ggggccgctg gctcagggta     1680

ggggagggtg gggcaatggg gacaggcaaa tgcagtttat tgtaatatat gggattagat     1740

tcatctatgg agggcagagt gggctgcctg gggattggga gggacagggc ttggggagca     1800

ggtctctggc agagaaggat gtccgttcca ggagcacacg gccctgcccc atcctgggcc     1860

atacctcccc tgccagggct cgggtgctct ggctcctgcc ttgatgaagc ccatgtcctg     1920

ccttgatgaa gcctgtgcta cctgcaagtg cccgccctgc ccctgtccca acacccaccg     1980

aagagccctg agctcaggct gagcccagcc acctcccaag gactttccag tgaggaaatg     2040

gcaacacgtg gaagtgaagt ccctgttctc agctctgtca tctgcggggc ttctgggtgg     2100

ctcctgccac cgacctcact ggcatgctag cctgtggcag gcctaggacc tcagcgggga     2160

ggaggagctg ccgcaaggcc ctatctcagc aggagaggga ggcttcctga ctgacacagg     2220

ctagccccat cttggtcctg tcaccctggc cccaactatt aaagtgccat ttcctgtcaa     2280

aaaaaaaaaa aaaaaaagaa aagggaggga gggagggagg gaggcaggaa ggaaggaaga     2340

gagggaggga gggaagggag gaagaaaggg aaagaaggga gggagggaaa tagaaagaaa     2400

gaaggaaaga aaaagaaaga aagagaaata aaataaaaat taaaaaacca taaggttaaa     2460

gtaaaccctt tttcttcata cagattaaaa cacatgactt caaattacag ctttgcttct     2520

taatagcttg gtgatgtagg atgttatgta acctctctgt gcctcagttt cctcatttat     2580

aaaatagggc aataataata tctagcccat aaggcattgt gaggattaaa tgtgaaatgc     2640

tgatcacaaa tacctagcag cccaatagat actcactgta ataattatta tttttataat     2700

ttctgcaaaa gtatggtgat gattcttggg ttaacctaaa ggcagatttt cttttatttc     2760

ttcctgtttc ttttcttttc cttgttcact ttaaagaatt aaaaagaaaa ttgattccag     2820

cattttggaa taaaaatttg catcaaaaag aatttattca ttttattgac atacaaataa     2880

aatgtcattt gtttattcaa taaacattta ttaaatgtct ggtaaatttc agacatcatg     2940

ccaggcacag ggatgacaat gacaataaga tgtggtctct gccctcaggg agctgatagt     3000

ccaggagact gacaagtaga caggtgatta catgcaatgt aacaaaggct atgatgtcat     3060

acaagaagac aagtgggagt atgtgatggg agtatggttt tgaccagttc ctcctcttag     3120

atttatccct ttttctttgg ctataaagca aaagaattgg tcctgttttt ttttcttaac     3180

tttgcaaatt aaaccataaa ttttaataac tttataaaga taaaaggcaa gcggtcagat     3240

tcagtggctc acacctataa tcccaacact ttgggaggcc gaggcaggtg gataacctga     3300

ggtcaggagt tcgagaccag cctggccaac atcgtgaaac cctgtctcta ctaaaaatac     3360

aaaaattagc tagttgtggt ggcaggcacc tgtaatccca gctactcagg aggctgaggc     3420

aggagaatcg cttgaacctg ggaggcggag tttgcagtga gatgagatgg agccattgct     3480

ctccagcctg ggctacagag caagactctg tctcaaaaca aaacaaaaca aaacaaaaag     3540

atgagcaact tgaattatgg aggacactag aaatagtgtt tcctacagaa tcagggcttc     3600

ctaccaacat agtcacttct agggttttcg acctgaaaag ttctgtggca tattgtttct     3660

ttgctatcca cttttttttc cctgtttttc cccctctttc tctcctctac tttatctcct     3720

agagatctag gtagttccca aaggaataat gctttacgga gtctaatgtt gatttattag     3780

gtaaaaacag aaaatgactt ttttttttac ccacaagttc cataccaaaa aatgaatgta     3840

aacttcttat gcagtttcac acattgaaaa tgcaggttat tttaattcca ttgcattttt     3900

cagaattctc aatcgcaatc ctctgacaac tgttgaagat ccgtatctct ttaaattact     3960

ggcattaaaa tatct                                                      3975


<210>  11
<211>  1762
<212>  DNA
<213>  Homo sapiens

<400>  11
cacgctgctg gtagatgagc acgcgcagct ggagccggtg agcctgcggc cgtgcttcgg       60

agactacagt gacgagagtg actcggccat cgtctatgac aactgtgcct ccgtctcctc      120

gccctatgag tcagccatcg gagaggaata tgaggaggcc tcccggcccc agcctcctgc      180

ctgcctctcc aaggactcca cgcctgacga acccgacgtc catttctcca agaagttcct      240

gaacatcttc atgagtggcc gctcccgctc ctccagtgcc gagtccttcg ggctgttctc      300

ctgcatcatc aaccgggagg agcaggagca gacccaccgg accatattca ggtttgtgcc      360

tcgacacgaa gacgaacctg agctggaagt ggatgaccct ctgctagtgg agctccaggc      420

tgaagactac tggtacgagg cctacaacat gcgcactggt gcccggggct tctttactgc      480

ctattacgcc atcgaagtca ccaaggagcc cgagcacatg gcagccctgg ctaaaaacag      540

tgactgggtg gaccagttcc gggtgaagtt cctgggctca gtccaggttc cctatcacaa      600

gggcgatgtc gtcctctctg ccgctatgca aaagattgcc accacccgcc ggctaaccgt      660

gcactttaac ccgccctcca gctgtgtcct ggagatcagc gtgcggggtg tgaagatagg      720

tgtcaaggcc gatgactccc aggaggccaa ggggaataaa tgtagccact ttttccagtt      780

aaaaaacatc tctttccgcg gatatcatcc aaagaacaac aagtactttg ggttcatcac      840

caagcacctc gccgaccacc ggtttgcctg ccacgtcttt gtgtctgaag actccaccaa      900

agccctggca gagtccgtgg ggagagcatt ccagcagttt cacaagcagt ttgtggagta      960

cacctgcccc acagaagata tctacctgga gtagccgcgc agccccgccc tctgcgtccc     1020

ccggccctca ggccagtgcc aggacagctg gctgctgaca ggatgtggca ctgcttgagg     1080

aggggcacct gccaccgcca ggggatgagg aagtgggggc cgctggctca gggtagggga     1140

gggtggggca atggggagag gcaaatgcag tttattgtaa tatatgggat tagattcatc     1200

tatggagggc agagtgggct gcctggggat tgggagggac agggcttggg gagcaggtct     1260

ctggcagaga aggatgtccg ttccaggagc acacggccct gccccatcct gggccatacc     1320

tcccctgcca gggctcgggt gctctggctc ctgccttgat gaagcccatg tcctgccttg     1380

atgaagcctg tgccacctgc aagtgcccgc cctgccccgt cccaacaccc accgaagaac     1440

cctgagctca ggctgagccc agccacctcc caaggacttt ccagtgagga aatggcaaca     1500

catggaagtg aagtccctgt tctcagctct gtcatctgcg gggcttctgg gtggctcctg     1560

ccaccgacct cactggcatg ctagcctgtg gcaggcctag gacctcagcg gggaggagga     1620

gctgccgcaa ggccctatcc cagcaggaga gggaggcttc ctgactgaca caggctagcc     1680

ccatcttggt cctgtcaccc tggccccaac tattaaagtg ccatttcctg tcaaaaaaaa     1740

aaaaaaaaaa aagaaaagaa aa                                              1762


<210>  12
<211>  3995
<212>  DNA
<213>  Homo sapiens

<400>  12
ggcggttgca cgcctgcgcg agggcgggcg gcgggggcgc gcgcgcggcg ggggcgggct       60

ttgccgagcg cagagctgca gccgccgagc cggacgtgtc cgcgaagatg gcgggccgga      120

gcatgcaagc ggcaagatgt cctacagatg aattatcttt aaccaattgt gcagttgtga      180

atgaaaagga tttccagtct ggccagcatg tgattgtgag gacctctccc aatcacaggt      240

acacatttac actgaagaca catccatcgg tggttccagg gagcattgca ttcagtttac      300

ctcagagaaa atgggctggg ctttctattg ggcaagaaat agaagtctcc ttatatacat      360

ttgacaaagc caaacagtgt attggcacaa tgaccatcga gattgatttc ctgcagaaaa      420

aaagcattga ctccaaccct tatgacaccg acaagatggc agcagaattt attcagcaat      480

tcaacaacca ggccttctca gtgggacaac agcttgtctt tagcttcaat gaaaagcttt      540

ttggcttact ggtgaaggac attgaagcca tggatcctag catcctgaag ggagagcctg      600

cgacagggaa aaggcagaag attgaagtag gactggttgt tggaaacagt caagttgcat      660

ttgaaaaagc agaaaattcg tcacttaatc ttattggcaa agctaaaacc aaggaaaatc      720

gccaatcaat tatcaatcct gactggaact ttgaaaaaat gggaatagga ggtctagaca      780

aggaattttc agatattttc cgacgagcat ttgcttcccg agtatttcct ccagagattg      840

tggagcagat gggttgtaaa catgttaaag gcatcctgtt atatggaccc ccaggttgtg      900

gtaagactct cttggctcga cagattggca agatgttgaa tgcaagagag cccaaagtgg      960

tcaatgggcc agaaatcctt aacaaatatg tgggagaatc agaggctaac attcgcaaac     1020

tttttgctga tgctgaagag gagcaaagga ggcttggtgc taacagtggt ttgcacatca     1080

tcatctttga tgaaattgat gccatctgca agcagagagg gagcatggct ggtagcacgg     1140

gagttcatga cactgttgtc aaccagttgc tgtccaaaat tgatggcgtg gagcagctaa     1200

acaacatcct agtcattgga atgaccaata gaccagatct gatagatgag gctcttctta     1260

gacctggaag actggaagtt aaaatggaga taggcttgcc agatgagaaa ggccgactac     1320

agattcttca catccacaca gcaagaatga gagggcatca gttactctct gctgatgtag     1380

acattaaaga actggccgtg gagaccaaga atttcagtgg tgctgaattg gagggtctgg     1440

tgcgagcagc ccagtccact gctatgaata gacacataaa ggccagtact aaagtggaag     1500

tggacatgga gaaagcagaa agcctgcaag tgacgagagg agacttcctt gcttctttgg     1560

agaatgatat caaaccagcc tttggcacaa accaagaaga ttatgcaagt tacattatga     1620

acggtatcat caaatggggt gacccagtta ctcgagttct agatgatggg gagctgctgg     1680

tgcagcagac taagaacagt gaccgcacac cattggtcag cgtgcttctg gaaggccctc     1740

ctcacagtgg gaagactgct ttagctgcaa aaattgcaga ggaatccaac ttcccgttca     1800

tcaagatctg ttctcctgat aaaatgattg gcttttctga aacagccaaa tgtcaggcca     1860

tgaagaagat ctttgatgat gcgtacaaat cccagctcag ttgtgtggtt gtggatgaca     1920

ttgagagatt gcttgattac gtccctattg gccctcgatt ttcaaatctt gtattacagg     1980

ctcttctcgt tttactgaaa aaggcacctc ctcagggccg caagcttctt atcattggga     2040

ccactagccg caaagatgtc cttcaggaga tggaaatgct taacgctttc agcaccacca     2100

tccacgtgcc caacattgcc acaggagagc agctgttgga agctttggag cttttgggca     2160

acttcaagga taaggaacgc accacaattg cacagcaagt caaagggaag aaggtctgga     2220

taggaatcaa gaagttacta atgctgatcg agatgtccct acagatggat cctgaatacc     2280

gtgtgagaaa attcttggcc ctcttaagag aagaaggagc tagccccctt gattttgatt     2340

gaaaatgaac tatttgaaac acacagtgac caagggaagt gaccaaggtg aagatggcct     2400

aggatcttca ctgtcttact caagatactg gactaagtgg aacgttctct accttcaaca     2460

tgtgctcgct ctgcatgatt agtgcaataa aactcccttc cttatgcata ctgagatagc     2520

ttagtgtctc gtggaaggtg tcaatttggt ttagaatgct gcgcttacct tcccatgcag     2580

gctaaagtga ttccttcttg ctcagtccct ctgggtggga accatccagt acttgtggac     2640

actacacgtt tcaacctctc tactagcacc atcacccttg aaaactctca gtcagtgtca     2700

tgaatgttgc atgacaacag ttggccgatt agaaggcaga ctttctacat gcaaatctgg     2760

cttagtaaat cgaggtgtgg gccagagatc ctctgacagc tgtcctgagc taacactaaa     2820

agtcactggg tatttggtta aaggtctccc acaagactgg tattctcttt gcctgaagaa     2880

acaaggcatt gaatctctaa aatgctgttc tcaatcattg tcagagatgt tttcaagttg     2940

cagtcagaag atctttctta atagaaagtc agatgactac cgtgttggtt gtgacttccc     3000

cttaagtata actaatttgc tctgtggtaa gagatatgct cattattacc acttagaaga     3060

tgttgttaaa aacatgtgaa agataggtat ggaaaaagca tacaccccca aacagaaagg     3120

agttattaaa gtaatttaca aacctctcag cactaattag tgtccaactc caagtgggtc     3180

aattccttag tataatatta aggcttacta gtatcactgc tttttcctta gcttaatgac     3240

ttacttagaa tttatccttt attttaaatg atctgtacta tctagtgtct aaaacactat     3300

tctccagaaa aatcaatcat tttctagccc tctccctcag tcctttattg tccattccaa     3360

tacattgaac acatttcctt taccctccac acacttcttc caaaaggaag cacccgttga     3420

gtccttttga gggtgatttg tcttacaact gactgactta gcaggaattt aattaggtca     3480

tatttggtga tgagacttat ggagtgtgcc tctctctccc aactgctgct taaaatgcaa     3540

ggacaagcaa ttagaagcca tcctaaggtg cttacctcac acgccaccca tgaggcttgt     3600

ggccacagtg gcacttgggt gtggctcctc tgttatttgt cctcatgtga gaaagcagat     3660

catctccaaa tcttgccatt tgtatacttt tggtggagac ttggatgtca tatcttcttt     3720

gttttgggtt ttcttcccta gcttattttg tggcttttaa agaagtggat tgtattgtga     3780

gatcctgtga ttcctggtgg ccagtatcct ggattcctct aagatcttgc ctctttcctc     3840

ctcatgaaag cagcacacat tgtgttaact tatgtctctt gttaaatgag cttaatgtct     3900

ttgtgttttg tccaaaactg tattgaaaaa atattgttta atgcaaatga aggaatgcaa     3960

taaagagtaa atatacttga aaaaaaaaaa aaaaa                                3995


<210>  13
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Leu Ser Ala Asp Val Asp Ile Lys Glu Leu Ala Val Glu Thr Lys 
1               5                   10                  15      


Asn Phe Ser Gly Ala Glu Leu Glu Gly Leu Val Arg Ala Ala Gln Ser 
            20                  25                  30          


Thr Ala Met Asn Arg His Ile Lys Ala Ser Thr Lys Val Glu Val Asp 
        35                  40                  45              


Met Glu Lys Ala Glu Ser Leu Gln Val Thr Arg Gly Asp Phe Leu Ala 
    50                  55                  60                  


Ser Leu Glu Asn Asp Ile Lys Pro Ala Phe Gly Thr Asn Gln Glu Asp 
65                  70                  75                  80  


Tyr Ala Ser Tyr Ile Met Asn Gly Ile Ile Lys Trp Gly Asp Pro Val 
                85                  90                  95      


Thr Arg Val Leu Asp Asp Gly Glu Leu Leu Val Gln Gln Thr Lys Asn 
            100                 105                 110         


Ser Asp Arg Thr Pro Leu Val Ser Val Leu Leu Glu Gly Pro Pro His 
        115                 120                 125             


Ser Gly Lys Thr Ala Leu Ala Ala Lys Ile Ala Glu Glu Ser Asn Phe 
    130                 135                 140                 


Pro Phe Ile Lys Ile Cys Ser Pro Asp Lys Met Ile Gly Phe Ser Glu 
145                 150                 155                 160 


Thr Ala Lys Cys Gln Ala Met Lys Lys Ile Phe Asp Asp Ala Tyr Lys 
                165                 170                 175     


Ser Gln Leu Ser Cys Val Val Val Asp Asp Ile Glu Arg Leu Leu Asp 
            180                 185                 190         


Tyr Val Pro Ile Gly Pro Arg Phe Ser Asn Leu Val Leu Gln Ala Leu 
        195                 200                 205             


Leu Val Leu Leu Lys Lys Ala Pro Pro Gln Gly Arg Lys Leu Leu Ile 
    210                 215                 220                 


Ile Gly Thr Thr Ser Arg Lys Asp Val Leu Gln Glu Met Glu Met Leu 
225                 230                 235                 240 


Asn Ala Phe Ser Thr Thr Ile His Val Pro Asn Ile Ala Thr Gly Glu 
                245                 250                 255     


Gln Leu Leu Glu Ala Leu Glu Leu Leu Gly Asn Phe Lys Asp Lys Glu 
            260                 265                 270         


Arg Thr Thr Ile Ala Gln Gln Val Lys Gly Lys Lys Val Trp Ile Gly 
        275                 280                 285             


Ile Lys Lys Leu Leu Met Leu Ile Glu Met Ser Leu Gln Met Asp Pro 
    290                 295                 300                 


Glu Tyr Arg Val Arg Lys Phe Leu Ala Leu Leu Arg Glu Glu Gly Ala 
305                 310                 315                 320 


Ser Pro Leu Asp Phe Asp 
                325     


<210>  14
<211>  1590
<212>  DNA
<213>  Homo sapiens

<400>  14
ccggtgtcgg gaagcaccag tgccctgagg aagggccatt tccaaaagcc ctgtgctgac       60

acagggttgc tggttcctct tcaagagccc actctctggg gtggggccat atctccagca      120

gaggtgggct ggaaaggacc cccccaatcc cgcccgccgt gagcttagct ggagccatgg      180

cctctgcacc catctcgatg cttgcgatgc tcttcacatt gagtgggctg agagctcagt      240

cagtggctca gccggaagat caggtcaacg ttgctgaagg gaatcctctg actgtgaaat      300

gcacctattc agtctctgga aacccttatc ttttttggta tgttcaatac cccaaccgag      360

gcctccagtt ccttctgaaa tacatcacag gggataacct ggttaaaggc agctatggct      420

ttgaagctga atttaacaag agccaaacct ccttccacct gaagaaacca tctgcccttg      480

tgagcgactc cgctttgtac ttctgtgctg tgagagacgc caaagctgca ggcaacaagc      540

taacttttgg aggaggaacc agggtgctag ttaaaccaaa tatccagaac cctgaccctg      600

ccgtgtacca gctgagagac tctaaatcca gtgacaagtc tgtctgccta ttcaccgatt      660

ttgattctca aacaaatgtg tcacaaagta aggattctga tgtgtatatc acagacaaaa      720

ctgtgctaga catgaggtct atggacttca agagcaacag tgctgtggcc tggagcaaca      780

aatctgactt tgcatgtgca aacgccttca acaacagcat tattccagaa gacaccttct      840

tccccagccc agaaagttcc tgtgatgtca agctggtcga gaaaagcttt gaaacagata      900

cgaacctaaa ctttcaaaac ctgtcagtga ttgggttccg aatcctcctc ctgaaagtgg      960

ccgggtttaa tctgctcatg acgctgcggc tgtggtccag ctgagatctg caagattgta     1020

agacagcctg tgctccctcg ctccttcctc tgcattgccc ctcttctccc tctccaaaca     1080

gagggaactc tcctaccccc aaggaggtga aagctgctac cacctctgtg cccccccggc     1140

aatgccacca actggatcct acccgaattt atgattaaga ttgctgaaga gctgccaaac     1200

actgctgcca ccccctctgt tcccttattg ctgcttgtca ctgcctgaca ttcacggcag     1260

aggcaaggct gctgcagcct cccctggctg tgcacattcc ctcctgctcc ccagagactg     1320

cctccgccat cccacagatg atggatcttc agtgggttct cttgggctct aggtcctgca     1380

gaatgttgtg aggggtttat ttttttttaa tagtgttcat aaagaaatac atagtattct     1440

tcttctcaag acgtgggggg aaattatctc attatcgagg ccctgctatg ctgtgtatct     1500

gggcgtgttg tatgtcctgc tgccgatgcc ttcattaaaa tgatttggaa gagcaaaaaa     1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      1590


<210>  15
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  15

Ile Lys Ala Ala Gly Asn Lys Leu Thr Phe Gly Gly Gly Thr Arg Val 
1               5                   10                  15      


Leu Val Lys Pro 
            20  


<210>  16
<211>  1001
<212>  DNA
<213>  Homo sapiens

<400>  16
aggcacttct atgccatttt agctattaga ttgaatcacc tctgggctcc ctttcaaatc       60

taaatgctaa gatcccatga ctcaagcctg gaggattaat aggtgagctc agacttgttt      120

cttctatttt tactattttg atagccaaag aaataattca tcaaattatt cataagctaa      180

agcctacttg ggatttttac acctagaaga tggtggggta tgatttccca gtgcagtaaa      240

tgagaaaaca ataggagaca tcaaggagga aaaaaagaag gaagagataa agggaatgtc      300

ttaagggagg ctcagaggtt gaatgaagga aatgaggtga ttttgcagag gacagatgtg      360

gctatcaaag attttacaat ttcacctttg gaaagggatc caaacataat gtcactccaa      420

gtaagtgagc agccttttgt actcgaaaat agggccaggg gagcaaagtt tcttccaatt      480

taaacacact caaaaggatg tgtaattgct ttctgatggg agggaactct gaaggtagaa      540

agactattgt taccacagat cacttgtccc tggagatata gcatctgagg actgactgtc      600

tagcttagac tgctgtctgc acaagaagaa gacttacaga tgcttaagga ggatggaggc      660

aaattttcaa ccctgtactc caaagctgag gggagagggg atgggaaaca ttagggctgg      720

gttcatgtaa aggggaccag cattgtgccg acagaggctc aaccctgggg aggctatact      780

ttggaagagg aactcagttg actgtctggc ctggtgagtg agtcgctttc tattccagga      840

aaatattact gtggagaaat taaaagggga gatgaattaa ctcctttagt cttgaaacta      900

aagagatatg tgtacttccc ctcctggagg accccagtcc ctaggtagat taggacgagg      960

aagcagaggg agacaaaggc gatggaaagt cccttttagg a                         1001


<210>  17
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  17

Tyr Gln Arg Phe Tyr Asn Phe Thr Phe Gly Lys Gly Ser Lys His Asn 
1               5                   10                  15      


Val Thr Pro 
            


<210>  18
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  18
tcagtttctt cttcctgcag ctggttgagt tctttccaga caaagacaag tgacaagaat       60

tagaggttta aaaagcaacc agattcatct cagcagcttt tgtagtttta aataagcaag      120

gagtttctcc agcgaaactt cctcacacct cttggtcttg gtctcttcag acactttcct      180

tcctgttctc tggagatctt gcagaaaaga gcctgcagtg tttcccttgc tcagccatgc      240

tcctggagct tatcccactg ctggggatac attttgtcct gagaactgcc agagcccagt      300

cagtgaccca gcctgacatc cacatcactg tctctgaagg agcctcactg gagttgagat      360

gtaactattc ctatggggca acaccttatc tcttctggta tgtccagtcc cccggccaag      420

gcctccagct gctcctgaag tacttttcag gagacactct ggttcaaggc attaaaggct      480

ttgaggctga atttaagagg agtcaatctt ccttcaacct gaggaaaccc tctgtgcatt      540

ggagtgatgc tgctgagtac ttctgtgctg                                       570


<210>  19
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Leu Leu Glu Leu Ile Pro Leu Leu Gly Ile His Phe Val Leu Arg 
1               5                   10                  15      


Thr Ala Arg Ala Gln Ser Val Thr Gln Pro Asp Ile His Ile Thr Val 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Glu Leu Arg Cys Asn Tyr Ser Tyr Gly Ala 
        35                  40                  45              


Thr Pro Tyr Leu Phe Trp Tyr Val Gln Ser Pro Gly Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Phe Ser Gly Asp Thr Leu Val Gln Gly Ile Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Lys Arg Ser Gln Ser Ser Phe Asn Leu Arg 
                85                  90                  95      


Lys Pro Ser Val His Trp Ser Asp Ala Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Gly 
    


<210>  20
<211>  1834
<212>  DNA
<213>  Homo sapiens

<400>  20
actttgacag tcttctcatg ctgcctctgc caccttctct gccagaagat accatttcaa       60

ctttaacaca gcatgatcga aacatacaac caaacttctc cccgatctgc ggccactgga      120

ctgcccatca gcatgaaaat ttttatgtat ttacttactg tttttcttat cacccagatg      180

attgggtcag cactttttgc tgtgtatctt catagaaggt tggacaagat agaagatgaa      240

aggaatcttc atgaagattt tgtattcatg aaaacgatac agagatgcaa cacaggagaa      300

agatccttat ccttactgaa ctgtgaggag attaaaagcc agtttgaagg ctttgtgaag      360

gatataatgt taaacaaaga ggagacgaag aaagaaaaca gctttgaaat gcaaaaaggt      420

gatcagaatc ctcaaattgc ggcacatgtc ataagtgagg ccagcagtaa aacaacatct      480

gtgttacagt gggctgaaaa aggatactac accatgagca acaacttggt aaccctggaa      540

aatgggaaac agctgaccgt taaaagacaa ggactctatt atatctatgc ccaagtcacc      600

ttctgttcca atcgggaagc ttcgagtcaa gctccattta tagccagcct ctgcctaaag      660

tcccccggta gattcgagag aatcttactc agagctgcaa atacccacag ttccgccaaa      720

ccttgcgggc aacaatccat tcacttggga ggagtatttg aattgcaacc aggtgcttcg      780

gtgtttgtca atgtgactga tccaagccaa gtgagccatg gcactggctt cacgtccttt      840

ggcttactca aactctgaac agtgtcacct tgcaggctgt ggtggagctg acgctgggag      900

tcttcataat acagcacagc ggttaagccc accccctgtt aactgcctat ttataaccct      960

aggatcctcc ttatggagaa ctatttatta tacactccaa ggcatgtaga actgtaataa     1020

gtgaattaca ggtcacatga aaccaaaacg ggccctgctc cataagagct tatatatctg     1080

aagcagcaac cccactgatg cagacatcca gagagtccta tgaaaagaca aggccattat     1140

gcacaggttg aattctgagt aaacagcaga taacttgcca agttcagttt tgtttctttg     1200

cgtgcagtgt ctttccatgg ataatgcatt tgatttatca gtgaagatgc agaagggaaa     1260

tggggagcct cagctcacat tcagttatgg ttgactctgg gttcctatgg ccttgttgga     1320

gggggccagg ctctagaacg tctaacacag tggagaaccg aaaccccccc cccccccccg     1380

ccaccctctc ggacagttat tcattctctt tcaatctctc tctctccatc tctctctttc     1440

agtctctctc tctcaacctc tttcttccaa tctctctttc tcaatctctc tgtttccctt     1500

tgtcagtctc ttccctcccc cagtctctct tctcaatccc cctttctaac acacacacac     1560

acacacacac acacacacac acacacacac acacacacac agagtcaggc cgttgctagt     1620

cagttctctt ctttccaccc tgtccctatc tctaccacta tagatgaggg tgaggagtag     1680

ggagtgcagc cctgagcctg cccactcctc attacgaaat gactgtattt aaaggaaatc     1740

tattgtatct acctgcagtc tccattgttt ccagagtgaa cttgtaatta tcttgttatt     1800

tattttttga ataataaaga cctcttaaca ttaa                                 1834


<210>  21
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  21

Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val 
1               5                   10                  15      


Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Val Leu Tyr 
            20                  25                  30          


Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser 
        35                  40                  45              


Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe 
    50                  55                  60                  


Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro 
65                  70                  75                  80  


Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro 
                85                  90                  95      


Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His 
            100                 105                 110         


Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu 
        115                 120                 


<210>  22
<211>  3684
<212>  DNA
<213>  Homo sapiens

<400>  22
aggatgttgc ctgcggctgg cggcccagtg gattctggga attgtagtcc cagccatcca       60

gggcattgcc gttcagggcc acgggaaaac ctgactgcgc tcccagaagc ctccggtgta      120

cctcgctggg aacgcacttc ctgggacgct gagagggaga cgctccaaga ggctcctcag      180

tgtgggcgag taaaatgccc tgcgtgtgag aagcaggctc agattattgc tactctgtat      240

tcagatcttc atgtgtctct tctaagctga ataaagctgt tttggaactg tcaggtacct      300

caaagcatga agaaaacgag gcacagggaa gttctgaatc tggcccaagt ctgactgaca      360

gtactccaca agcttgcctg ccatgggctg tcgggatgtc cacgcagcca cagtcctttc      420

cttcctgtgt ggaatcgcct cagtagcagg cctctttgca gggactctgc ttcccaactg      480

gagaaaatta cgattgatca cattcaacag aaacgagaag aacctgactg tttacacagg      540

cctgtgggtg aaatgtgccc ggtatgacgg gagcagtgac tgcctgatgt acgacactac      600

ttggtactca tcagttgacc agctggacct gcgtgtcctc cagtttgccc tacccctcag      660

catgctgatc gccatgggtg ccctgctgct ctgcctgatt ggaatgtgca acactgcctt      720

caggtcctcg gtgcccaaca tcaaactggc caagtgtctg gtcaatagtg caggttgcca      780

cctggtggct gggctgctat ttttcctggc aggtactgtg agcctctccc catctatctg      840

ggtcatcttt tataacatcc atctgaacaa gaagtttgag ccagtctttt catttgacta      900

tgcagtgtat gtcactattg ctagtgctgg gggcctgttt atgacttccc ttatactatt      960

tatttggtat tgtacatgca aatctttgcc ttctcctttc tggcaaccat tgtactccca     1020

tccacccagt atgcatactt actcacagcc ctattcagca cgctctcgcc tctctgccat     1080

tgaaattgac attccagtag tttcacacac cacttaatgg ggaaatagtt aattgttaaa     1140

gaaaacttct tgtagcctca cattcccctt gtgcaaagag ctcttttgga cctacataca     1200

ttttcctttg tttttgacca atcaatgaag ccaaatttat atgtcctagt agaatgaagt     1260

gctgctagtt tttatgagaa gtatattata ttaaatgtga attttttaaa ttttgcttct     1320

tatactggaa ggaattttag ccttcatatt gatatctaat taattattta agtggaagag     1380

gcctgcatca caattgaggt aatgtagagc aacatgttaa agaatgatgg ttagcagaag     1440

ctgttgtata caatcttcat gaaaatttca gtgtgtattt ttctttttct ataatacctt     1500

taactgcaaa gaaaaggcag tttcaaatat aagaaattta tttcaggtaa gggtaatatt     1560

ttaatagtag tcaataatct agcttaaggc tgtaactctt ctatcggggc taattgtatg     1620

aataggtgtc agtatgttga agattacttt cttttgtgac tttcttctac ctcatgccac     1680

tgtttaaaag taaaacgtat tttaatgatg ttagaataag actaccattc taaatatcac     1740

ctacttatga ataacatgta ataattttta acattaatga ttccataaat tgtattattg     1800

ggattagaat gtgctttatg acaggttagt gtttcctctg aggcagaaaa ctcttttttg     1860

gagatatctt ccatcaagca gtactcgtgc ccatatacaa tctcttagtg gctaggagaa     1920

ataaataaaa gggccataat ggtttgttct ctttcagaca taatttagta ggggacaaga     1980

agtctgttct tcagtgagta cactagagat ttactctggt gactgccttt tgagttatgg     2040

gtgaagtaag gtatggcttt accataacct tgattcattc acccttgatt catttctcgc     2100

ccccgtcact gattatttcc ttgagcatat atctctgcct aacactttag taggtgctat     2160

agaggataca tgaaaagtat gagatctggt tccatccagt aagacatttt aatagagaag     2220

atcaaaatgt tacctggcag ttggggaata atctgacttc gttggcagtt ggccttaact     2280

tcttaatcat tgatccagga atatttcaac cagagacaca actttctggc agacagacaa     2340

attgtacaac accaacaata tcctggacct tgaaattctg tttacttcag tccattgtat     2400

cctttaaggc acctgtgcta gcctagattt tgtaataaca ctgatttatg agaatggaca     2460

aaagtggtag ggaaattgtt ccctctccac ttctgaaagt atgatgatgt attaaggatg     2520

gaggagttat taaaaatgtc tcttctgatg aggtaacaat tagatgaaac catgttaaag     2580

ctgagatgaa cacttagaaa ttcagggata ttgggtcttt agccttatga atttgagctg     2640

cttatttaat tggtgtaatt tactacatat tagtactata ttcgtaagga ttttttatta     2700

accattacag attttacaaa cagctagtta tatggtaaac agattattat gcctttttgc     2760

aattctgaat atgattctag tatttgtgta gatgtatttg gtactttttc ccctaattcc     2820

aacactagtt tatatatata gcgaataaat ctagttgtat aaatttttaa atgccgtcag     2880

tagaaagcac acaaggttat gattttttta attactggct tctgatttct ttcacttctg     2940

atccttttcc tttttctcag atgtagctga gtcttgatca ttttaagaca acgatgggta     3000

gaattttgag attaatgtta attttccctt tttgttaatt tcagtcccct ctcactatgc     3060

ttttgtccag aaggatcaag aattctacca tcccttgggt ctttgtgtat aaacaatgtt     3120

aaataaaggt agactcagtc tttaagatat tagacagttt ttttagtcca tgggattgta     3180

aatataaaca ttaactttcc tataagaata ttttggcttt gtaatctata gcctcaaatt     3240

ggtatttatt atggattcac tagacaaaca gctgtttcct tattgtcttt tttctttagt     3300

gtttctgatt tgctatcagt agctgttttt aaagccgtcc aaggaaaata attatttaca     3360

gtttttgaag tcacttttga gccctcatca agctctcatt gtgatgggag ggataccttt     3420

ttgttgttaa aagcctatta ttgttaaagg ccttttatgg aaaccaactt ggaaaacaac     3480

cttaaatgtg gatgtatcag atttggttta tccagccatg ggagagaaaa caaacctaag     3540

tttactttac ttgtacatat acactacaat ggatagtata tttgctgtaa actacaatgt     3600

aaaacctcaa taaaagtgcg ctgtacttct taatgtttat taaaagatgt atttttacaa     3660

aaaaaaaaaa aaaaaaaaaa aaaa                                            3684


<210>  23
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gly Cys Arg Asp Val His Ala Ala Thr Val Leu Ser Phe Leu Cys 
1               5                   10                  15      


Gly Ile Ala Ser Val Ala Gly Leu Phe Ala Gly Thr Leu Leu Pro Asn 
            20                  25                  30          


Trp Arg Lys Leu Arg Leu Ile Thr Phe Asn Arg Asn Glu Lys Asn Leu 
        35                  40                  45              


Thr Val Tyr Thr Gly Leu Trp Val Lys Cys Ala Arg Tyr Asp Gly Ser 
    50                  55                  60                  


Ser Asp Cys Leu Met Tyr Asp Thr Thr Trp Tyr Ser Ser Val Asp Gln 
65                  70                  75                  80  


Leu Asp Leu Arg Val Leu Gln Phe Ala Leu Pro Leu Ser Met Leu Ile 
                85                  90                  95      


Ala Met Gly Ala Leu Leu Leu Cys Leu Ile Gly Met Cys Asn Thr Ala 
            100                 105                 110         


Phe Arg Ser Ser Val Pro Asn Ile Lys Leu Ala Lys Cys Leu Val Asn 
        115                 120                 125             


Ser Ala Gly Cys His Leu Val Ala Gly Leu Leu Phe Phe Leu Ala Gly 
    130                 135                 140                 


Thr Val Ser Leu Ser Pro Ser Ile Trp Val Ile Phe Tyr Asn Ile His 
145                 150                 155                 160 


Leu Asn Lys Lys Phe Glu Pro Val Phe Ser Phe Asp Tyr Ala Val Tyr 
                165                 170                 175     


Val Thr Ile Ala Ser Ala Gly Gly Leu Phe Met Thr Ser Leu Ile Leu 
            180                 185                 190         


Phe Ile Trp Tyr Cys Thr Cys Lys Ser Leu Pro Ser Pro Phe Trp Gln 
        195                 200                 205             


Pro Leu Tyr Ser His Pro Pro Ser Met His Thr Tyr Ser Gln Pro Tyr 
    210                 215                 220                 


Ser Ala Arg Ser Arg Leu Ser Ala Ile Glu Ile Asp Ile Pro Val Val 
225                 230                 235                 240 


Ser His Thr Thr 
                


<210>  24
<211>  5229
<212>  DNA
<213>  Homo sapiens

<400>  24
agaaagctgc ggcgcgagtc cgcggggccg acctcggaga cgcagctggg gccgggcgcg       60

gcttggcggg agggtctgca gcgccgaggg aggctgctgg tgcgtgagga agagagctag      120

agactggaca ggggaggcag agcagcgtca gagccgcgca ggggacggga gtgagagcag      180

gagcgacgca gagcggccgt cgccgtgccc gggtctcagg gcgcctggct gaagtgagca      240

tggcttcagt ggcctgggcc gtcctcaagg tgctgctgct tctccccact cagacttgga      300

gccccgtggg agcaggaaat ccacctgact gtgatgcccc actggcctct gccttgccta      360

ggtcatcctt cagcagctcc tcagagctgt ccagcagcca cggcccgggg ttttcaaggc      420

ttaatcgaag agatggagct ggtggctgga ctccacttgt gtcaaataaa taccaatggc      480

tgcaaattga ccttggagag agaatggagg tcactgctgt cgccacccaa ggaggatatg      540

ggagctctga ctgggtgacc agctacctcc tgatgttcag tgatggtggg agaaactgga      600

agcagtatcg ccgagaagaa agcatctggg gttttccagg aaacacaaac gcagacagtg      660

tggtgcacta cagactccag cctccctttg aagccaggtt cctgcgcttt ctccctttag      720

cctggaaccc taggggcagg attgggatgc ggatcgaagt gtacggatgt gcatataaat      780

ctgaggtggt ttattttgat ggacaaagtg ctctgctgta tagacttgat aaaaaacctt      840

taaaaccaat aagagacgtt atttctttga aatttaaagc catgcagagc aatggaattc      900

tacttcacag agaaggacaa catggaaatc acattactct ggaattaatt aaaggaaagc      960

ttgtcttttt tcttaattca ggcaatgcta agctgccttc cactattgct cctgtgaccc     1020

tcaccctggg cagcctgctg gacgaccagc actggcattc cgtcctcatc gagctcctcg     1080

acacgcaggt caacttcacc gtggacaaac acactcatca tttccaagca aagggagatt     1140

ccagttactt ggatcttaat tttgagatca gctttggggg aattccgaca cccggaagat     1200

cgcgggcatt cagacgtaaa agctttcatg ggtgtttaga aaatctttat tataatggag     1260

tggatgttac cgaattagcc aagaaacaca aaccacagat cctcatgatg ggaaatgtgt     1320

ccttctcatg tccacagcca cagactgtcc ctgtgacttt tctgagctcc aggagttatc     1380

tggctctgcc aggcaactct ggggaggaca aagtgtctgt cacttttcaa tttcgaacgt     1440

ggaacagagc aggacatttg cttttcggcg aacttcgacg tggttcaggg agtttcgtcc     1500

tctttcttaa ggatggcaag ctcaaactga gtctcttcca gccgggacag tcaccaagga     1560

atgtcacagc aggtgctgga ttaaacgatg ggcagtggca ctctgtgtcc ttctctgcca     1620

agtggagcca tatgaatgtg gtggtggacg atgacacagc tgttcagccc ctggtggctg     1680

tgctcattga ttcaggtgac acctattatt ttggaggctg cctggacaac agctctggct     1740

ctggatgtaa aagccccctg ggagggtttc agggctgcct aaggctcatc accattggtg     1800

acaaagcggt ggatcccatc ttagtacagc agggggcgct ggggagtttc agggacctcc     1860

agatagactc ctgcggcatc acagacaggt gcttgcccag ctactgtgag catgggggcg     1920

agtgttccca gtcgtgggac accttctcct gtgactgtct aggcacaggc tatacgggcg     1980

agacctgcca ttcctctctc tacgagcagt cttgtgaagc ccacaagcac cgagggaacc     2040

cgtctgggct ttactatatt gatgcagatg gaagtggccc cctgggacca tttcttgtgt     2100

actgcaatat gacagcagac gccgcgtgga cggtggtgca gcacggtggc cccgacgcgg     2160

tgaccctccg aggtgccccc agcgggcacc cgcgctcggc tgtgtccttc gcgtacgcag     2220

cgggcgcggg gcagctgcgg tccgcggtga acctggcgga gcgctgcgag cagcggctgg     2280

ctctgcgctg cgggacggcg cggcgcccgg actcacgaga tggaacccca ctgagctggt     2340

gggttggaag aaccaatgaa acacacactt cctggggagg ttctctgcct gatgctcaaa     2400

agtgtacttg tggattagag gggaactgca ttgattctca gtattactgc aactgtgatg     2460

ctggccggaa tgaatggact agtgacacaa tagtcctttc ccaaaaggag cacctgccag     2520

tcactcagat tgtgatgaca gacgcaggcc gaccacattc cgaagcagct tatacactgg     2580

ggccactgct ctgccgcgga gatcagtcat tctggaattc agcttccttc aacactgaga     2640

cttcatacct tcatttccct gctttccacg gagaactcac tgctgacgtg tgcttctttt     2700

ttaagaccac agtttcctcc ggggtgttta tggagaacct ggggatcaca gatttcatca     2760

ggattgagct gcgtgctccc acagaagtga ccttttcctt cgatgtgggg aatggacctt     2820

gtgaggtcac ggtgcagtca cccactccct ttaatgacaa tcagtggcac cacgtgaggg     2880

cagagagaaa tgttaaagga gcgtctcttc aagttgatca gcttcctcag aagatgcagc     2940

ctgcccctgc tgatgggcac gttcgtttac agctcaacag ccagctcttc attggtggaa     3000

cggccaccag acagagaggc tttctaggat gcattcggtc tctgcagttg aacggggtgg     3060

ccctggatct ggaagaaaga gccacagtga cgccaggagt ggagccaggg tgtgcaggac     3120

actgcagcac ctatggacac ttgtgtcgca atggagggag atgcagagag aaacgcaggg     3180

gggtcacctg tgactgtgcc ttctcagcct atgatgggcc gttctgctcc aatgagattt     3240

ccgcatattt tgcaactggc tcctcaatga cataccattt tcaagaacat tacactttaa     3300

gtgaaaactc cagctctctc gtttcttcat tacacagaga tgtaacattg accagagaaa     3360

tgatcacact gagcttccga accacacgaa ctccgagctt attgctgtat gtgagctctt     3420

tctatgagga atacctttca gttatcctcg ccaacaatgg aagtttgcag attaggtaca     3480

agctagatag acatcaaaat cctgatgcat ttacctttga ttttaaaaac atggctgatg     3540

ggcaacttca ccaagtgaag attaacagag aagaagctgt ggtcatggta gaggttaacc     3600

agagcacaaa gaaacaagtc atcttgtcct cagggacaga attcaacgcc gtcaaatctc     3660

tcatattggg aaaggtttta gaggctgccg gcgcggaccc ggacacaagg cgggcggcga     3720

ctagtggctt cactggctgc ctctcggcgg tgcgcttcgg ccgcgctgct cccctgaagg     3780

cggcgctgcg ccccagcggc ccctcccggg tcaccgtccg cggccacgtg gcccctatgg     3840

cccgctgcgc agcgggggcg gcgtccggct ccccggcgcg ggaactggct ccccgactcg     3900

cggggggcgc aggtcgttct ggaccagcgg atgagggaga gcccttggtt aatgcagaca     3960

gaagagactc tgctgtcatc ggaggtgtga tagcagtggt gatatttatt ttgctttgca     4020

tcactgccat agccatacgc atctatcaac agagaaagtt acgcaaagaa aatgagtcaa     4080

aagtctcaaa aaaagaagag tgctaggaca gctctaaaca gtgagctcga tgtgcaaaac     4140

gcagtccatg aaaaccagaa agagcgagtc ttctgattgg cagctgtggc tgtctctatc     4200

atcgtgactg tggacttccc tgctgttgcc atcagggtgc acacaagcag gtgcagtgct     4260

gtcacctggc tgaagacctg cagcctcgga gcctctggga ggtccctttc tccctcggtg     4320

aaacacagtc ctccacatca atttccaaac aatgaattag gtatggccat tcatcactgt     4380

tcagtagttt ccccgtccaa aggctctctt ccaaaactgc agtttgatct gtgttaataa     4440

ttgtggggtt ttagatgaga aaatggctat aaagctgtgg ccctacttta ttttttaaaa     4500

atgacagaac ttttgttcag atgtaaaaga caaaattgca ctttaatgtt ttttgttact     4560

tgaaaacata tctgggatcc ctttttttgg tcctctgctg atatttataa aacaagaaat     4620

gcttcttgga ctaccttcac tggcatttcc atagtcctgg aatccagagc caagtggcct     4680

atctaaaatt cacagccctt ttattctcct gtgtgatggt taatacaaca cagttgaagc     4740

ctggaaacac taccattatt tttggtgtat tgctttttct aattgactgt ttttaatgat     4800

tttgatacat tttaatgttg aaattaatat tgaatgttag ctatgaaatt ttagtattga     4860

attttataat ggaacagaac attggtaggt aacaagatgc aagaggatgt caatacaaga     4920

ttgtctgcct gtttttcttt gtaatttgta attacagttt ttgtaacttg tgattatgtt     4980

tttaactaaa tttaccacca gatacaaaca atacttctta cacagagtta tcctttattt     5040

atatcattaa gacgtgaatg aaacatcatc ctaacttact tccccaagat attgagaggt     5100

catatctgtt tttctttatc attcatttct ttttctaaaa gttgttactg atatgctttt     5160

gatttcctat gactctatta tgttgtacag aacatctttt caatttatta aaaaaatagc     5220

ttaactgaa                                                             5229


<210>  25
<211>  1288
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp 
            20                  25                  30          


Ala Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser 
        115                 120                 125             


Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu 
145                 150                 155                 160 


Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly 
                165                 170                 175     


Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu 
            180                 185                 190         


Leu Tyr Arg Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys 
225                 230                 235                 240 


Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile 
                245                 250                 255     


Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Tyr Leu 
    290                 295                 300                 


Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Pro Thr Pro Gly Arg 
305                 310                 315                 320 


Ser Arg Ala Phe Arg Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro 
            340                 345                 350         


Gln Ile Leu Met Met Gly Asn Val Ser Phe Ser Cys Pro Gln Pro Gln 
        355                 360                 365             


Thr Val Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Gly Asn Ser Gly Glu Asp Lys Val Ser Val Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Arg Ala Gly His Leu Leu Phe Gly Glu Leu Arg Arg Gly Ser 
                405                 410                 415     


Gly Ser Phe Val Leu Phe Leu Lys Asp Gly Lys Leu Lys Leu Ser Leu 
            420                 425                 430         


Phe Gln Pro Gly Gln Ser Pro Arg Asn Val Thr Ala Gly Ala Gly Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Phe Ser Ala Lys Trp Ser His 
    450                 455                 460                 


Met Asn Val Val Val Asp Asp Asp Thr Ala Val Gln Pro Leu Val Ala 
465                 470                 475                 480 


Val Leu Ile Asp Ser Gly Asp Thr Tyr Tyr Phe Gly Gly Cys Leu Asp 
                485                 490                 495     


Asn Ser Ser Gly Ser Gly Cys Lys Ser Pro Leu Gly Gly Phe Gln Gly 
            500                 505                 510         


Cys Leu Arg Leu Ile Thr Ile Gly Asp Lys Ala Val Asp Pro Ile Leu 
        515                 520                 525             


Val Gln Gln Gly Ala Leu Gly Ser Phe Arg Asp Leu Gln Ile Asp Ser 
    530                 535                 540                 


Cys Gly Ile Thr Asp Arg Cys Leu Pro Ser Tyr Cys Glu His Gly Gly 
545                 550                 555                 560 


Glu Cys Ser Gln Ser Trp Asp Thr Phe Ser Cys Asp Cys Leu Gly Thr 
                565                 570                 575     


Gly Tyr Thr Gly Glu Thr Cys His Ser Ser Leu Tyr Glu Gln Ser Cys 
            580                 585                 590         


Glu Ala His Lys His Arg Gly Asn Pro Ser Gly Leu Tyr Tyr Ile Asp 
        595                 600                 605             


Ala Asp Gly Ser Gly Pro Leu Gly Pro Phe Leu Val Tyr Cys Asn Met 
    610                 615                 620                 


Thr Ala Asp Ala Ala Trp Thr Val Val Gln His Gly Gly Pro Asp Ala 
625                 630                 635                 640 


Val Thr Leu Arg Gly Ala Pro Ser Gly His Pro Arg Ser Ala Val Ser 
                645                 650                 655     


Phe Ala Tyr Ala Ala Gly Ala Gly Gln Leu Arg Ser Ala Val Asn Leu 
            660                 665                 670         


Ala Glu Arg Cys Glu Gln Arg Leu Ala Leu Arg Cys Gly Thr Ala Arg 
        675                 680                 685             


Arg Pro Asp Ser Arg Asp Gly Thr Pro Leu Ser Trp Trp Val Gly Arg 
    690                 695                 700                 


Thr Asn Glu Thr His Thr Ser Trp Gly Gly Ser Leu Pro Asp Ala Gln 
705                 710                 715                 720 


Lys Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln Tyr Tyr 
                725                 730                 735     


Cys Asn Cys Asp Ala Gly Arg Asn Glu Trp Thr Ser Asp Thr Ile Val 
            740                 745                 750         


Leu Ser Gln Lys Glu His Leu Pro Val Thr Gln Ile Val Met Thr Asp 
        755                 760                 765             


Ala Gly Arg Pro His Ser Glu Ala Ala Tyr Thr Leu Gly Pro Leu Leu 
    770                 775                 780                 


Cys Arg Gly Asp Gln Ser Phe Trp Asn Ser Ala Ser Phe Asn Thr Glu 
785                 790                 795                 800 


Thr Ser Tyr Leu His Phe Pro Ala Phe His Gly Glu Leu Thr Ala Asp 
                805                 810                 815     


Val Cys Phe Phe Phe Lys Thr Thr Val Ser Ser Gly Val Phe Met Glu 
            820                 825                 830         


Asn Leu Gly Ile Thr Asp Phe Ile Arg Ile Glu Leu Arg Ala Pro Thr 
        835                 840                 845             


Glu Val Thr Phe Ser Phe Asp Val Gly Asn Gly Pro Cys Glu Val Thr 
    850                 855                 860                 


Val Gln Ser Pro Thr Pro Phe Asn Asp Asn Gln Trp His His Val Arg 
865                 870                 875                 880 


Ala Glu Arg Asn Val Lys Gly Ala Ser Leu Gln Val Asp Gln Leu Pro 
                885                 890                 895     


Gln Lys Met Gln Pro Ala Pro Ala Asp Gly His Val Arg Leu Gln Leu 
            900                 905                 910         


Asn Ser Gln Leu Phe Ile Gly Gly Thr Ala Thr Arg Gln Arg Gly Phe 
        915                 920                 925             


Leu Gly Cys Ile Arg Ser Leu Gln Leu Asn Gly Val Ala Leu Asp Leu 
    930                 935                 940                 


Glu Glu Arg Ala Thr Val Thr Pro Gly Val Glu Pro Gly Cys Ala Gly 
945                 950                 955                 960 


His Cys Ser Thr Tyr Gly His Leu Cys Arg Asn Gly Gly Arg Cys Arg 
                965                 970                 975     


Glu Lys Arg Arg Gly Val Thr Cys Asp Cys Ala Phe Ser Ala Tyr Asp 
            980                 985                 990         


Gly Pro Phe Cys Ser Asn Glu Ile  Ser Ala Tyr Phe Ala  Thr Gly Ser 
        995                 1000                 1005             


Ser Met  Thr Tyr His Phe Gln  Glu His Tyr Thr Leu  Ser Glu Asn 
    1010                 1015                 1020             


Ser Ser  Ser Leu Val Ser Ser  Leu His Arg Asp Val  Thr Leu Thr 
    1025                 1030                 1035             


Arg Glu  Met Ile Thr Leu Ser  Phe Arg Thr Thr Arg  Thr Pro Ser 
    1040                 1045                 1050             


Leu Leu  Leu Tyr Val Ser Ser  Phe Tyr Glu Glu Tyr  Leu Ser Val 
    1055                 1060                 1065             


Ile Leu  Ala Asn Asn Gly Ser  Leu Gln Ile Arg Tyr  Lys Leu Asp 
    1070                 1075                 1080             


Arg His  Gln Asn Pro Asp Ala  Phe Thr Phe Asp Phe  Lys Asn Met 
    1085                 1090                 1095             


Ala Asp  Gly Gln Leu His Gln  Val Lys Ile Asn Arg  Glu Glu Ala 
    1100                 1105                 1110             


Val Val  Met Val Glu Val Asn  Gln Ser Thr Lys Lys  Gln Val Ile 
    1115                 1120                 1125             


Leu Ser  Ser Gly Thr Glu Phe  Asn Ala Val Lys Ser  Leu Ile Leu 
    1130                 1135                 1140             


Gly Lys  Val Leu Glu Ala Ala  Gly Ala Asp Pro Asp  Thr Arg Arg 
    1145                 1150                 1155             


Ala Ala  Thr Ser Gly Phe Thr  Gly Cys Leu Ser Ala  Val Arg Phe 
    1160                 1165                 1170             


Gly Arg  Ala Ala Pro Leu Lys  Ala Ala Leu Arg Pro  Ser Gly Pro 
    1175                 1180                 1185             


Ser Arg  Val Thr Val Arg Gly  His Val Ala Pro Met  Ala Arg Cys 
    1190                 1195                 1200             


Ala Ala  Gly Ala Ala Ser Gly  Ser Pro Ala Arg Glu  Leu Ala Pro 
    1205                 1210                 1215             


Arg Leu  Ala Gly Gly Ala Gly  Arg Ser Gly Pro Ala  Asp Glu Gly 
    1220                 1225                 1230             


Glu Pro  Leu Val Asn Ala Asp  Arg Arg Asp Ser Ala  Val Ile Gly 
    1235                 1240                 1245             


Gly Val  Ile Ala Val Val Ile  Phe Ile Leu Leu Cys  Ile Thr Ala 
    1250                 1255                 1260             


Ile Ala  Ile Arg Ile Tyr Gln  Gln Arg Lys Leu Arg  Lys Glu Asn 
    1265                 1270                 1275             


Glu Ser  Lys Val Ser Lys Lys  Glu Glu Cys 
    1280                 1285             


<210>  26
<211>  6379
<212>  DNA
<213>  Homo sapiens

<400>  26
agagggacgg aggaagctgc cggtataacg ggaggagagc gccaggcgga gctggggcgt       60

ccctcccgct cgcttcttga ctcgcgttgg tgccggccgc ctcccgcgcc tagtgtccgg      120

gacgcgcctg aacctgccgc ctccgtgcct ggggcggcgc cgcgcggccc ccaggctccc      180

gcggggccga cctcggagac gcagctgggg ccgggcgcgg cttggcggga gggtctgcag      240

cgccgaggga ggctgccagt gcgtgaggaa gagagctaga gactggacag gggagacaga      300

gcagcgtcgg agccgcgcag gggacgggag tgagagcggg agtgagagca ggaacgacgc      360

agagcggccg tcgccgtgcc cgggtctcag ggcgcctggc tgaagtgagc atggcttcag      420

tggcctgggc cgtcctcaag gtgctgctgc ttctccccac tcagacttgg agccccgtag      480

gagcaggaaa tccacctgac tgtgattccc cactggcctc tgccttgcct aggtcatcct      540

tcagcagctc ctcagagctg tccagcagcc acggcccggg gttttcaagg cttaatcgaa      600

gagatggagc tggtggctgg accccacttg tgtcaaataa ataccaatgg ctgcaaattg      660

accttggaga gagaatggag gtcactgctg tcgccaccca aggaggatat gggagctctg      720

actgggtgac cagctacctc ctgatgttca gtgatggtgg gagaaactgg aagcagtatc      780

gccgagaaga aagcatctgg ggttttccag gaaacacaaa cgcagacagt gtggtgcact      840

acagactcca gcctcccttt gaagccaggt tcctgcgctt tctcccttta gcctggaacc      900

ccaggggcag gattgggatg cggatcgaag tgtacggatg tgcatataaa tctgaggtgg      960

tttattttga tggacaaagt gctctgctgt atacacttga taaaaaacct ttaaaaccaa     1020

taagagatgt tatttctttg aaatttaaag ccatgcagag caatggaatt ctacttcaca     1080

gagaaggaca acatggaaat cacattactc tggaattaat taaaggaaag cttgtctttt     1140

ttcttaattc aggcaatgct aagctgcctt ctactattgc tcctgtgacc ctcaccctgg     1200

gcagcctgct ggatgaccag cactggcatt ccgtcctcat cgagctcctc gacacgcagg     1260

tcaacttcac cgtggacaaa cacactcatc atttccaagc aaagggagat tccagtaact     1320

tggatcttaa ttttgagatc agctttgggg gaattctgtc acccggaaga tcacgggcat     1380

tcacacgtaa aagctttcat gggtgtttag aaaatcttta ttataatgga gtggatgtta     1440

ccgaattagc caagaaacac aaaccacaga tcctcatgat gggaaatgtg tccttctcat     1500

gtccacagcc acagactgtc cctgtgactt ttctgagctc caggagttat ctggctctgc     1560

caggcaactc tggggaggac aaagtgtctg tcacttttca atttcgaacg tggaacagag     1620

caggacattt gcttttcggc gaacttcaac gtggttcagg gagtttcgtc ctctttctta     1680

aggatggcaa gctcaaactg agtctcttcc aggcgggaca gtcaccaagg aatgtcacag     1740

caggtgctgg attaaacgat gggcagtggc actctgtatc cttctctgcc aagtggagcc     1800

atatgaatgt ggtggtggat gatgacacag ctgttcagcc cctggtggct gtgctcattg     1860

attcaggtga cacctattat tttggaggct gcctgggcaa cagctctggc tctggatgta     1920

aaagccccct gggagggttt cagggctgcc taaggctcat caccattggt gacaaagcgg     1980

tggatcccat cttagtacag cagggggcgc tggggagttt cagggacctc cagatagact     2040

cctgcggcat cacagacagg tgcttgccca gctactgtga gcatgggggc gagtgttccc     2100

agtcgtggga caccttctcc tgtgactgtc taggcacagg ctatacgggc gagacctgcc     2160

attcctctct ctacgagcag tcttgtgaag cccacaagca ccgagggaac ccatccgggc     2220

tttactatat tgatgcagat ggaagtggcc ccctgggacc atttcttgtg tactgcaata     2280

tgacagcaga ctccgcgtgg acggtggtgc ggcacggtgg ccccgacgcg gtgaccctcc     2340

gaggtgcccc cagcgggcac ccgctctcgg ctgtgtcctt cgcgtacgca gcgggcgcgg     2400

ggcagctgcg ggccgcggtg aacctggcgg agcgctgcga gcagcggctg gctctgcgct     2460

gcgggacagc gcggcgcccg gactcacgag atggaacccc actgagctgg tgggttggaa     2520

gaaccaatga aacacacact tcctggggag gttctctgcc tgatgctcaa aagtgtactt     2580

gtggattaga ggggaactgc attgattctc agtattactg caactgtgat gctggccaga     2640

atgaatggac tagtgacaca atagtccttt cccaaaagga gcacctccca gtcactcaga     2700

ttgtgatgac agacacaggc caaccacatt ccgaagcaga ttatacactg gggccactgc     2760

tctgccgcgg agataagtca ttttggaatt cagcttcctt caacactgag acttcatacc     2820

ttcatttccc tgctttccac ggagaactca ctgctgacgt gtgcttcttt tttaagacca     2880

cagtttcctc tggggtgttt atggagaacc tggggatcac agacttcatc aggattgagc     2940

tgcgggctcc cacagaagtg acattttcct tcgatgtggg gaatggacct tgtgaggtca     3000

cggtgcagtc acccactccc tttaatgaca atcagtggca ccacgtgagg gcagagagaa     3060

atgttaaagg agcgtctctt caagttgatc agcttcctca gaagatgcag cctgcccctg     3120

ctgatgggca cgttcgttta cagctcaaca gccagctctt cattggtgga acggccacca     3180

gacagagagg ctttctagga tgcattcggt ctctgcagtt gaacggggtg gccctggatc     3240

tggaagaaag agccacagtg acgccaggag tggagccagg gtgtgcagga cactgcagca     3300

cctatggaca cttgtgtcgc aatggaggga gatgcagaga gaaacgcagg ggggtcacct     3360

gtgactgtgc cttctcagcc tatgatggac cgttctgctc caatgagatt tccgcatatt     3420

tcgcaactgg ctcctcaatg acataccatt ttcaagaaca ttacacttta agtgaaaact     3480

ccagctctct cgtttcttca ttacacagag atgtaacatt gaccagagaa atgatcacac     3540

tgagcttccg aaccacacga actccgagct tattgctgta tgtgagctct ttctatgagg     3600

aatacctttc agttatcctc gccaacaatg gaagtttgca gattaggtac aagctagata     3660

gacatcaaaa tcctgatgca tttacctttg attttaaaaa catggctgat gggcaacttc     3720

accaagtgaa gattaacaga gaagaagccg tggtcatggt agaggttaac cagagcgcaa     3780

agaaacaagt catcttgtcc tcagggacag aattcaacgc cgtcaaatct ctcatattgg     3840

gaaaggtttt agaggctgcc ggcgcggacc cggacacaag gcgggcggcg actagtggct     3900

tcactggctg cctctcggcg gtgcgcttcg gctgcgctgc tcccctgaag gcggcgctgc     3960

gccccagcgg cccctcccgg gtcaccgtcc gcggccacgt ggcccctatg gcccgctgcg     4020

cggcgggggc ggcgtccggc tccccggcgc gggaactggc tccccgactc gcggggggcg     4080

caggtcgttc tggaccagtg gatgagggag agcccttggt taatgcagac agaagagact     4140

ctgctgtcat cggaggtgtg atagcagtgg agatatttat tttgctttgc atcactgcca     4200

tagccatacg catctatcaa cagagaaagt tacgcaaaga aaatgagtca aaagtctcaa     4260

aaaaagaaga gtgctaggac agctctaaac agtgagctcg atgtgcaaaa cgcagtccat     4320

gaaaaccaga aagagtgagt cttctgattg gcagctgtgg ctgtctctat catcgtgact     4380

gtggacttcc ctgctgttgc catcagggtg cacacagcag gtgcagtgct gtcacctggc     4440

tgaagatctg cagcctcaga gcctctggga ggtccctttc tccctcggtg aaacacagtc     4500

ctccacatca atttccaaac aatgaattag gtatggccat tcatcactgt tcagtagttt     4560

ccccgtccaa aggctctctt ccaaaactgc agtttgatct gtgttaataa ttgtggggtt     4620

ttagatgaga aaatgactat aaagctgtgg ccctacttta ttttttaaaa atgacagaac     4680

ttttgttcag atgtaaaaga caaaattgca ctttaatgtt ttttgttact tgaaaacata     4740

tctgggatcc ctttttttgg tcctctgctg atattataaa acaagaaatg cttcttggac     4800

taccttcact ggcatttcca tagtcctgga atccagagcc aagtggccta tctaaaattc     4860

acagcccttt tattctcctg tgtgatggtt aatacaacac agttgaagcc tggaaacact     4920

accattattt ttggtgtatt gctttttcta attgactgtt tttaatgatt ttgatacatt     4980

ttaatgttga aattaatatt gaatgttagc tatgaaattt tagtattgaa ttttataatg     5040

gaacagaaca ttggtaggta acaagatgca agaggatgtc aatacaagat tgtctgcctg     5100

tttttctttg taatttgtaa ttacagtttt tgtaacttgt gattatgttt ttaactaaat     5160

ttaccaccag atacaaacac tacttcttac acagagttat cctttattta tatcattaag     5220

acgtgaatga aacatcatcc taacttactt ccccaagata ttgagaggtc atatctgttt     5280

ttcatcattc atttcttttt ctaaaagttg ttactgatat gcttttgatt tcctatgact     5340

ctattatgtt gtacagaaca tcttttcaat ttattaaaaa aaatagctta actgaagatc     5400

actaattcct tttctaaatt ttgaactgct ctaggcataa atatcattgt gtattatcct     5460

ttcatctaat cacttttgga atgtaaactg aaggctgttc actccaagtt aagttaacat     5520

ttacatgatg tttattaaat ctgccagtct gatcaaaggt ttatgaccat ggggccaaat     5580

tcccatagat tacccaaaat tgaatatgtg cagttaactg gaacatgtct cattaaggtt     5640

tacatacaca ctaagacagc aaaggattgg aattaacttt atggagacag ttccagggac     5700

taatattgaa gcagtggtta tttgataatg catggaacca ccatttggat tcaataaacc     5760

aattacataa aagcaatgat gctacgctct tcatattcca gataccaact gcctaccaag     5820

gactaatgag atggtatatt tcttccacat cagggcaagc tgaaaatata ttgattcagc     5880

gttactgtta tgtaaatgaa tttccatctt ctcatatgtg ttatttttga aagaatgaat     5940

acactctctg tcttaaatcc gctcttaaca aatgatctct tctcagaata ctacatctgt     6000

attgagagta cagacagccc attggtcact gcaccttttg caagacagcg aaacggatgc     6060

atcaaattgc attgatacat catcaccatc aatcttttgc actgattttt agacttaatc     6120

ttcttatttg aaaataaact catttttaaa taaaataaaa aatattttag ggaaagctct     6180

ataaaattaa aattacagaa ttatatgctt tttaaaattt atgcaaaaat gtgcagacaa     6240

atgtattctg tattggttta tgtatcactt tgcccttgta tattttgaga ttattaagat     6300

ttgttgactt ttttggtttg atatttatca tctgttaaat ttttcctttt aaattattaa     6360

atgcaaagtg caagaaaaa                                                  6379


<210>  27
<211>  1288
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp 
            20                  25                  30          


Ser Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser 
        115                 120                 125             


Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu 
145                 150                 155                 160 


Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly 
                165                 170                 175     


Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu 
            180                 185                 190         


Leu Tyr Thr Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys 
225                 230                 235                 240 


Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile 
                245                 250                 255     


Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Asn Leu 
    290                 295                 300                 


Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Leu Ser Pro Gly Arg 
305                 310                 315                 320 


Ser Arg Ala Phe Thr Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro 
            340                 345                 350         


Gln Ile Leu Met Met Gly Asn Val Ser Phe Ser Cys Pro Gln Pro Gln 
        355                 360                 365             


Thr Val Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Gly Asn Ser Gly Glu Asp Lys Val Ser Val Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Arg Ala Gly His Leu Leu Phe Gly Glu Leu Gln Arg Gly Ser 
                405                 410                 415     


Gly Ser Phe Val Leu Phe Leu Lys Asp Gly Lys Leu Lys Leu Ser Leu 
            420                 425                 430         


Phe Gln Ala Gly Gln Ser Pro Arg Asn Val Thr Ala Gly Ala Gly Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Phe Ser Ala Lys Trp Ser His 
    450                 455                 460                 


Met Asn Val Val Val Asp Asp Asp Thr Ala Val Gln Pro Leu Val Ala 
465                 470                 475                 480 


Val Leu Ile Asp Ser Gly Asp Thr Tyr Tyr Phe Gly Gly Cys Leu Gly 
                485                 490                 495     


Asn Ser Ser Gly Ser Gly Cys Lys Ser Pro Leu Gly Gly Phe Gln Gly 
            500                 505                 510         


Cys Leu Arg Leu Ile Thr Ile Gly Asp Lys Ala Val Asp Pro Ile Leu 
        515                 520                 525             


Val Gln Gln Gly Ala Leu Gly Ser Phe Arg Asp Leu Gln Ile Asp Ser 
    530                 535                 540                 


Cys Gly Ile Thr Asp Arg Cys Leu Pro Ser Tyr Cys Glu His Gly Gly 
545                 550                 555                 560 


Glu Cys Ser Gln Ser Trp Asp Thr Phe Ser Cys Asp Cys Leu Gly Thr 
                565                 570                 575     


Gly Tyr Thr Gly Glu Thr Cys His Ser Ser Leu Tyr Glu Gln Ser Cys 
            580                 585                 590         


Glu Ala His Lys His Arg Gly Asn Pro Ser Gly Leu Tyr Tyr Ile Asp 
        595                 600                 605             


Ala Asp Gly Ser Gly Pro Leu Gly Pro Phe Leu Val Tyr Cys Asn Met 
    610                 615                 620                 


Thr Ala Asp Ser Ala Trp Thr Val Val Arg His Gly Gly Pro Asp Ala 
625                 630                 635                 640 


Val Thr Leu Arg Gly Ala Pro Ser Gly His Pro Leu Ser Ala Val Ser 
                645                 650                 655     


Phe Ala Tyr Ala Ala Gly Ala Gly Gln Leu Arg Ala Ala Val Asn Leu 
            660                 665                 670         


Ala Glu Arg Cys Glu Gln Arg Leu Ala Leu Arg Cys Gly Thr Ala Arg 
        675                 680                 685             


Arg Pro Asp Ser Arg Asp Gly Thr Pro Leu Ser Trp Trp Val Gly Arg 
    690                 695                 700                 


Thr Asn Glu Thr His Thr Ser Trp Gly Gly Ser Leu Pro Asp Ala Gln 
705                 710                 715                 720 


Lys Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln Tyr Tyr 
                725                 730                 735     


Cys Asn Cys Asp Ala Gly Gln Asn Glu Trp Thr Ser Asp Thr Ile Val 
            740                 745                 750         


Leu Ser Gln Lys Glu His Leu Pro Val Thr Gln Ile Val Met Thr Asp 
        755                 760                 765             


Thr Gly Gln Pro His Ser Glu Ala Asp Tyr Thr Leu Gly Pro Leu Leu 
    770                 775                 780                 


Cys Arg Gly Asp Lys Ser Phe Trp Asn Ser Ala Ser Phe Asn Thr Glu 
785                 790                 795                 800 


Thr Ser Tyr Leu His Phe Pro Ala Phe His Gly Glu Leu Thr Ala Asp 
                805                 810                 815     


Val Cys Phe Phe Phe Lys Thr Thr Val Ser Ser Gly Val Phe Met Glu 
            820                 825                 830         


Asn Leu Gly Ile Thr Asp Phe Ile Arg Ile Glu Leu Arg Ala Pro Thr 
        835                 840                 845             


Glu Val Thr Phe Ser Phe Asp Val Gly Asn Gly Pro Cys Glu Val Thr 
    850                 855                 860                 


Val Gln Ser Pro Thr Pro Phe Asn Asp Asn Gln Trp His His Val Arg 
865                 870                 875                 880 


Ala Glu Arg Asn Val Lys Gly Ala Ser Leu Gln Val Asp Gln Leu Pro 
                885                 890                 895     


Gln Lys Met Gln Pro Ala Pro Ala Asp Gly His Val Arg Leu Gln Leu 
            900                 905                 910         


Asn Ser Gln Leu Phe Ile Gly Gly Thr Ala Thr Arg Gln Arg Gly Phe 
        915                 920                 925             


Leu Gly Cys Ile Arg Ser Leu Gln Leu Asn Gly Val Ala Leu Asp Leu 
    930                 935                 940                 


Glu Glu Arg Ala Thr Val Thr Pro Gly Val Glu Pro Gly Cys Ala Gly 
945                 950                 955                 960 


His Cys Ser Thr Tyr Gly His Leu Cys Arg Asn Gly Gly Arg Cys Arg 
                965                 970                 975     


Glu Lys Arg Arg Gly Val Thr Cys Asp Cys Ala Phe Ser Ala Tyr Asp 
            980                 985                 990         


Gly Pro Phe Cys Ser Asn Glu Ile  Ser Ala Tyr Phe Ala  Thr Gly Ser 
        995                 1000                 1005             


Ser Met  Thr Tyr His Phe Gln  Glu His Tyr Thr Leu  Ser Glu Asn 
    1010                 1015                 1020             


Ser Ser  Ser Leu Val Ser Ser  Leu His Arg Asp Val  Thr Leu Thr 
    1025                 1030                 1035             


Arg Glu  Met Ile Thr Leu Ser  Phe Arg Thr Thr Arg  Thr Pro Ser 
    1040                 1045                 1050             


Leu Leu  Leu Tyr Val Ser Ser  Phe Tyr Glu Glu Tyr  Leu Ser Val 
    1055                 1060                 1065             


Ile Leu  Ala Asn Asn Gly Ser  Leu Gln Ile Arg Tyr  Lys Leu Asp 
    1070                 1075                 1080             


Arg His  Gln Asn Pro Asp Ala  Phe Thr Phe Asp Phe  Lys Asn Met 
    1085                 1090                 1095             


Ala Asp  Gly Gln Leu His Gln  Val Lys Ile Asn Arg  Glu Glu Ala 
    1100                 1105                 1110             


Val Val  Met Val Glu Val Asn  Gln Ser Ala Lys Lys  Gln Val Ile 
    1115                 1120                 1125             


Leu Ser  Ser Gly Thr Glu Phe  Asn Ala Val Lys Ser  Leu Ile Leu 
    1130                 1135                 1140             


Gly Lys  Val Leu Glu Ala Ala  Gly Ala Asp Pro Asp  Thr Arg Arg 
    1145                 1150                 1155             


Ala Ala  Thr Ser Gly Phe Thr  Gly Cys Leu Ser Ala  Val Arg Phe 
    1160                 1165                 1170             


Gly Cys  Ala Ala Pro Leu Lys  Ala Ala Leu Arg Pro  Ser Gly Pro 
    1175                 1180                 1185             


Ser Arg  Val Thr Val Arg Gly  His Val Ala Pro Met  Ala Arg Cys 
    1190                 1195                 1200             


Ala Ala  Gly Ala Ala Ser Gly  Ser Pro Ala Arg Glu  Leu Ala Pro 
    1205                 1210                 1215             


Arg Leu  Ala Gly Gly Ala Gly  Arg Ser Gly Pro Val  Asp Glu Gly 
    1220                 1225                 1230             


Glu Pro  Leu Val Asn Ala Asp  Arg Arg Asp Ser Ala  Val Ile Gly 
    1235                 1240                 1245             


Gly Val  Ile Ala Val Glu Ile  Phe Ile Leu Leu Cys  Ile Thr Ala 
    1250                 1255                 1260             


Ile Ala  Ile Arg Ile Tyr Gln  Gln Arg Lys Leu Arg  Lys Glu Asn 
    1265                 1270                 1275             


Glu Ser  Lys Val Ser Lys Lys  Glu Glu Cys 
    1280                 1285             


<210>  28
<211>  3319
<212>  DNA
<213>  Homo sapiens

<400>  28
ggaatggagg ccaacgtcaa agccagcctg ttccccagag tgcctggcta gcctggagca       60

agggcccgca gccctgcctg tgtgcagagt ggcgtgcctg tttggatgtg ctggaggagg      120

aggaggagga agcagagcca ccataccagg gccgtgcggg ctgtgcgggc tgtagggcgt      180

acacacacac acatacacac acacacacac acacacacag gcacacagat gcaagctgtg      240

tgaatcaccc agcctgtgag tcagcgccag gattcctgtc ggggaatgag tgagaccagg      300

ctgaggctgt ctgtccccag accccagagc acgtccggca ccaccatgac tgggctgttg      360

aagaggaaat ttgaccagct ggatgaggac aactcctcgg tctcctcctc ctcctcttcc      420

tctgggtgcc agtctcgctc ctgctcccca agctcttctg tctcccgtgc ctgggactca      480

gaggaggaag gcccctggga tcagatgccc ctgcctgacc gtgacttctg cggccccaga      540

agtttcaccc ccctgtctat cctgaagcgg gctcgccggg agcgcccagg ccgtgtagcc      600

tttgatggga tcaccgtctt ctacttcccc cgctgccagg gcttcaccag tgtgcccagc      660

cgtggtggct gtactctggg tatggccctt cgccacagtg cttgccgtcg cttctctttg      720

gctgagtttg cgcaggagca agcccgtgca cggcacgaga agctccgcca gcgcttgaaa      780

gaggagaagt tggagatgct gcagtggaag ctttcggcag ctggggtacc ccaggcagag      840

gcagggctgc cacctgtggt ggatgccatt gatgacgcct ctgtggagga ggacttggca      900

gtcgctgtgg caggtggccg gttggaagaa gtgagcttcc tacagcccta cccagcccgg      960

cgacgtcgag ctctgctgag ggcttcaggt gtgcgaagga tcgatcggga ggagaagcgg     1020

gagctgcagg cactgcgcca atcccgggag gattgtggct gtcactgcga taggatctgc     1080

gaccctgaga cctgcagctg cagcctggca ggcatcaagt gccagatgga ccacacagca     1140

ttcccctgtg gctgctgcag ggagggctgt gagaacccca tgggccgtgt ggaatttaat     1200

caggcaagag ttcagaccca tttcatccac acactcaccc gcctgcagtt ggaacaggag     1260

gctgagagct ttagggagct ggaggcccct gcccagggca gcccacccag ccctggtgag     1320

gaggccctgg tccctacttt cccactggcc aagcccccca tgaacaatga gctgggagac     1380

aacagctgca gcagcgacat gactgattct tctacagcat cttcatcagc atcgggcact     1440

agtgaggctc ctgactgccc cacccaccca ggcctgcctg gccctggctt ccagcctggc     1500

gttgatgatg acagcctggc acgcatcttg agtttcagtg actctgactt cggtggggag     1560

gaggaggaag aggaggaagg gagcgtgggg aacctggaca acctcagctg cttccatcca     1620

gctgacatct ttggtactag tgaccctggt ggcctggcca gctggaccca cagctattct     1680

ggctgtagct tcacatcagg cgtcctggat gagaatgcca acctggatgc cagctgcttc     1740

ctaaatggtg gccttgaagg gtcaagggaa ggcagccttc ctggcacctc agtgccaccc     1800

agcatggacg ctggccggag tagctcagtg gatctcagct tgtcttcttg tgactccttt     1860

gagttactcc aggctctgcc agattatagt ctggggcctc actacacatc acagaaggtg     1920

tctgacagcc tggacaacat cgaggcacct cacttccccc tgcctggcct gtctccacct     1980

ggggatgcca gcagttgctt cctggagtcc ctcatgggct tctccgagcc agccgccgaa     2040

gccctagatc cctttattga cagccagttt gaggacactg tcccagcatc tctaatggag     2100

cctgtgccgg tgtgaggacc aggatgtctt ttcccagccc caagagacct gttgctgctt     2160

tcttgtaatt atggggctcc ccagagtctg cgtaacagtc tcccactggc tggctcaccc     2220

acaggtgcca tgtgcacact cctggttttc aaacaattct ctggatttat ttatttgttt     2280

taacttttct gtgctgaaga gaggactggg gggagggggc ttcccctttc agctgcccgg     2340

ccccccacac ccacagcttg ctcttctatc tccacaacgt gagcctggaa gaggagaaaa     2400

tgtggctcct ctggagcttg gcagaccact tttcggtctt tgcgtgatgt tccttagccc     2460

aaagacggtg agacagggct gaaatcaggt ggcttctgcc accctgagcc ctagacccat     2520

gggtggctaa atccactgga ctgtgaagac tataatttat ttccataatt tatttggaga     2580

ttgaggaggc tttggttgca cttctttggc tggtgggtaa tgccaggggt ggggtgggca     2640

caggccctca agagcccctt ttgccttgta gtcctacacc ttgccctgcc tgggctttgg     2700

tgcagactag gtgtggattt gagctctgtg atctatgtct gctgcctggc tcctagatgg     2760

ctctgtgggc aggtgctggc caaggacatc atctaggcag ggggagagcc tgggctgaac     2820

agctgtgacc aaaactccct tctgccccac cctgccccct ccacttcctg ccctctgttc     2880

catcttcccc cttcccaaag gccacagcct ttattccagg cccagggatg taggaggggg     2940

aaggaggaaa caggaagccc agagagggca aagggcctac ctcggggcgc gaaccatgcc     3000

ccagactatt atctcagggc tttctgggca ctgcacttca gcgtggccca cctgcccatg     3060

ccctgaggcc agttggcgag gggtggctcc tgagggtttt tatacccttt gtttgctaat     3120

gtttaatttt gcatcataat ttctacattg tccctgagtg tcagaactat aatttattcc     3180

atttctctct gtgtctgtgc caagaaacgc aggctctggg cctgcccctt gcccaggagg     3240

ccttgccagc ctgtgtgctt gtgggaacac cttgtacctg agcttacagg taccaataaa     3300

gaggctttat ttttagcaa                                                  3319


<210>  29
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Thr Gly Leu Leu Lys Arg Lys Phe Asp Gln Leu Asp Glu Asp Asn 
1               5                   10                  15      


Ser Ser Val Ser Ser Ser Ser Ser Ser Ser Gly Cys Gln Ser Arg Ser 
            20                  25                  30          


Cys Ser Pro Ser Ser Ser Val Ser Arg Ala Trp Asp Ser Glu Glu Glu 
        35                  40                  45              


Gly Pro Trp Asp Gln Met Pro Leu Pro Asp Arg Asp Phe Cys Gly Pro 
    50                  55                  60                  


Arg Ser Phe Thr Pro Leu Ser Ile Leu Lys Arg Ala Arg Arg Glu Arg 
65                  70                  75                  80  


Pro Gly Arg Val Ala Phe Asp Gly Ile Thr Val Phe Tyr Phe Pro Arg 
                85                  90                  95      


Cys Gln Gly Phe Thr Ser Val Pro Ser Arg Gly Gly Cys Thr Leu Gly 
            100                 105                 110         


Met Ala Leu Arg His Ser Ala Cys Arg Arg Phe Ser Leu Ala Glu Phe 
        115                 120                 125             


Ala Gln Glu Gln Ala Arg Ala Arg His Glu Lys Leu Arg Gln Arg Leu 
    130                 135                 140                 


Lys Glu Glu Lys Leu Glu Met Leu Gln Trp Lys Leu Ser Ala Ala Gly 
145                 150                 155                 160 


Val Pro Gln Ala Glu Ala Gly Leu Pro Pro Val Val Asp Ala Ile Asp 
                165                 170                 175     


Asp Ala Ser Val Glu Glu Asp Leu Ala Val Ala Val Ala Gly Gly Arg 
            180                 185                 190         


Leu Glu Glu Val Ser Phe Leu Gln Pro Tyr Pro Ala Arg Arg Arg Arg 
        195                 200                 205             


Ala Leu Leu Arg Ala Ser Gly Val Arg Arg Ile Asp Arg Glu Glu Lys 
    210                 215                 220                 


Arg Glu Leu Gln Ala Leu Arg Gln Ser Arg Glu Asp Cys Gly Cys His 
225                 230                 235                 240 


Cys Asp Arg Ile Cys Asp Pro Glu Thr Cys Ser Cys Ser Leu Ala Gly 
                245                 250                 255     


Ile Lys Cys Gln Met Asp His Thr Ala Phe Pro Cys Gly Cys Cys Arg 
            260                 265                 270         


Glu Gly Cys Glu Asn Pro Met Gly Arg Val Glu Phe Asn Gln Ala Arg 
        275                 280                 285             


Val Gln Thr His Phe Ile His Thr Leu Thr Arg Leu Gln Leu Glu Gln 
    290                 295                 300                 


Glu Ala Glu Ser Phe Arg Glu Leu Glu Ala Pro Ala Gln Gly Ser Pro 
305                 310                 315                 320 


Pro Ser Pro Gly Glu Glu Ala Leu Val Pro Thr Phe Pro Leu Ala Lys 
                325                 330                 335     


Pro Pro Met Asn Asn Glu Leu Gly Asp Asn Ser Cys Ser Ser Asp Met 
            340                 345                 350         


Thr Asp Ser Ser Thr Ala Ser Ser Ser Ala Ser Gly Thr Ser Glu Ala 
        355                 360                 365             


Pro Asp Cys Pro Thr His Pro Gly Leu Pro Gly Pro Gly Phe Gln Pro 
    370                 375                 380                 


Gly Val Asp Asp Asp Ser Leu Ala Arg Ile Leu Ser Phe Ser Asp Ser 
385                 390                 395                 400 


Asp Phe Gly Gly Glu Glu Glu Glu Glu Glu Glu Gly Ser Val Gly Asn 
                405                 410                 415     


Leu Asp Asn Leu Ser Cys Phe His Pro Ala Asp Ile Phe Gly Thr Ser 
            420                 425                 430         


Asp Pro Gly Gly Leu Ala Ser Trp Thr His Ser Tyr Ser Gly Cys Ser 
        435                 440                 445             


Phe Thr Ser Gly Val Leu Asp Glu Asn Ala Asn Leu Asp Ala Ser Cys 
    450                 455                 460                 


Phe Leu Asn Gly Gly Leu Glu Gly Ser Arg Glu Gly Ser Leu Pro Gly 
465                 470                 475                 480 


Thr Ser Val Pro Pro Ser Met Asp Ala Gly Arg Ser Ser Ser Val Asp 
                485                 490                 495     


Leu Ser Leu Ser Ser Cys Asp Ser Phe Glu Leu Leu Gln Ala Leu Pro 
            500                 505                 510         


Asp Tyr Ser Leu Gly Pro His Tyr Thr Ser Gln Lys Val Ser Asp Ser 
        515                 520                 525             


Leu Asp Asn Ile Glu Ala Pro His Phe Pro Leu Pro Gly Leu Ser Pro 
    530                 535                 540                 


Pro Gly Asp Ala Ser Ser Cys Phe Leu Glu Ser Leu Met Gly Phe Ser 
545                 550                 555                 560 


Glu Pro Ala Ala Glu Ala Leu Asp Pro Phe Ile Asp Ser Gln Phe Glu 
                565                 570                 575     


Asp Thr Val Pro Ala Ser Leu Met Glu Pro Val Pro Val 
            580                 585                 


<210>  30
<211>  569
<212>  DNA
<213>  Homo sapiens

<400>  30
ttctttacca aatcaatctc ttgcttttta acattttatt tacttttcct tgaagactaa       60

ttaagaattc aggcaggtga tgaatggttt tcaataccag aagcacagga aggggaaaga      120

gttccaggaa cgtctgcttc ttgagatccc cacatctgtg aactggagag agaaaggcta      180

catgagtcct gtgaaggatc aggttaaaac ctgtaggtac aatcccaagt attctgttgc      240

taatgacact ggctttgtgg acataccttc atgggagaag gacctggcga aggcagtggc      300

aactgtgggg cccatctctg ttgctgttga tgcaagccat gtctccttcc agttctataa      360

aaaaagctgg ggtaaaaact ggggcatgga tggctacata aagatggcca aagaccggag      420

gaacaactgt ggaatcacca cagcagccag ctacccaact gtgtgagctg atggatggtg      480

atgaggaagg actcgactga ggatggcaca tccagaggag gaactgatct tcaatctacc      540

agcccctgct gtgtgaaatg cacacttca                                        569


<210>  31
<211>  1718
<212>  DNA
<213>  Homo sapiens

<400>  31
gagggtgcat aagttctcta gtagggtgat gatataaaaa gccaccggag cactccataa       60

ggcacaaact ttcagagaca gcagagcaca caagcttcta ggacaagagc caggaagaaa      120

ccaccggaag gaaccatctc actgtgtgta aacatgactt ccaagctggc cgtggctctc      180

ttggcagcct tcctgatttc tgcagctctg tgtgaaggtg cagttttgcc aaggagtgct      240

aaagaactta gatgtcagtg cataaagaca tactccaaac ctttccaccc caaatttatc      300

aaagaactga gagtgattga gagtggacca cactgcgcca acacagaaat tattgtaaag      360

ctttctgatg gaagagagct ctgtctggac cccaaggaaa actgggtgca gagggttgtg      420

gagaagtttt tgaagagggc tgagaattca taaaaaaatt cattctctgt ggtatccaag      480

aatcagtgaa gatgccagtg aaacttcaag caaatctact tcaacacttc atgtattgtg      540

tgggtctgtt gtagggttgc cagatgcaat acaagattcc tggttaaatt tgaatttcag      600

taaacaatga atagtttttc attgtaccat gaaatatcca gaacatactt atatgtaaag      660

tattatttat ttgaatctac aaaaaacaac aaataatttt taaatataag gattttccta      720

gatattgcac gggagaatat acaaatagca aaattgaggc caagggccaa gagaatatcc      780

gaactttaat ttcaggaatt gaatgggttt gctagaatgt gatatttgaa gcatcacata      840

aaaatgatgg gacaataaat tttgccataa agtcaaattt agctggaaat cctggatttt      900

tttctgttaa atctggcaac cctagtctgc tagccaggat ccacaagtcc ttgttccact      960

gtgccttggt ttctccttta tttctaagtg gaaaaagtat tagccaccat cttacctcac     1020

agtgatgttg tgaggacatg tggaagcact ttaagttttt tcatcataac ataaattatt     1080

ttcaagtgta acttattaac ctatttatta tttatgtatt tatttaagca tcaaatattt     1140

gtgcaagaat ttggaaaaat agaagatgaa tcattgattg aatagttata aagatgttat     1200

agtaaattta ttttatttta gatattaaat gatgttttat tagataaatt tcaatcaggg     1260

tttttagatt aaacaaacaa acaattgggt acccagttaa attttcattt cagataaaca     1320

acaaataatt ttttagtata agtacattat tgtttatctg aaattttaat tgaactaaca     1380

atcctagttt gatactccca gtcttgtcat tgccagctgt gttggtagtg ctgtgttgaa     1440

ttacggaata atgagttaga actattaaaa cagccaaaac tccacagtca atattagtaa     1500

tttcttgctg gttgaaactt gtttattatg tacaaataga ttcttataat attatttaaa     1560

tgactgcatt tttaaataca aggctttata tttttaactt taagatgttt ttatgtgctc     1620

tccaaatttt ttttactgtt tctgattgta tggaaatata aaagtaaata tgaaacattt     1680

aaaatataat ttgttgtcaa agtaaaaaaa aaaaaaaa                             1718


<210>  32
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210>  33
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  33
tggctctgac cgcgctggcc tgggccggag agcccaggag gcgtgtctca gagaaaagat       60

ataagcggcc cccggacgct aaagcggtgc cagcggcgga gtctccaact gggagagctg      120

cagctgccga gaggaggaga acgctgaggt cggtcggacc aacggacgcg ctgaccgctg      180

ccaactgcag ctcgcgctgc ctcctgctcg cgccgtgcca ctaaggtcat tcccgcctcc      240

gagagcccag agccgagatg gaaacggtcc aggagctgat ccccctggcc aaggagatga      300

tggcccagaa gcgcaagggg aagatggtga agctgtacgt gctgggcagc gtgctggccc      360

tcttcggcgt ggtgctcggc ctgatggaga ctgtgtgcag ccccttcacg gccgccagac      420

gtctgcggga ccaggaggca gccgtggcgg agctgcaggc cgccctggag cgacaggctc      480

tccagaagca agccctgcag gagaaaggca agcagcagga cacggtcctc ggcggccggg      540

ccctgtccaa ccggcagcac gcctcctagg aactgtggga gaccagcgga gtgggaggga      600

gacgcagtag acagagacag accgagagag gaatggagag acagaggggg cgcgcgcaca      660

ggagcctgac tccgctggga gagtgcagga gcacgtgctg ttttttattt ggacttaact      720

tcagagaaac cgctgacatc tagaactgac ctaccacaag catccaccaa aggagtttgg      780

gattgagttt tgctgctgtg cagcactgca ttgtcatgac atttccaaca ctgtgtgaat      840

tatctaaatg cgtctaccat tttgcactag ggaggaagga taaatgcttt ttatgttatt      900

attattaatt attacaatga ccaccatttt gcattttgaa ataaaaaaac tttttatacc      960

ataaaaaaaa aaaaaaaa                                                    978


<210>  34
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Glu Thr Val Gln Glu Leu Ile Pro Leu Ala Lys Glu Met Met Ala 
1               5                   10                  15      


Gln Lys Arg Lys Gly Lys Met Val Lys Leu Tyr Val Leu Gly Ser Val 
            20                  25                  30          


Leu Ala Leu Phe Gly Val Val Leu Gly Leu Met Glu Thr Val Cys Ser 
        35                  40                  45              


Pro Phe Thr Ala Ala Arg Arg Leu Arg Asp Gln Glu Ala Ala Val Ala 
    50                  55                  60                  


Glu Leu Gln Ala Ala Leu Glu Arg Gln Ala Leu Gln Lys Gln Ala Leu 
65                  70                  75                  80  


Gln Glu Lys Gly Lys Gln Gln Asp Thr Val Leu Gly Gly Arg Ala Leu 
                85                  90                  95      


Ser Asn Arg Gln His Ala Ser 
            100             


<210>  35
<211>  3436
<212>  DNA
<213>  Homo sapiens

<400>  35
tcaatgcact gttcaaggat gtttgagaga ttttctgtct tgcctgaata caaaacactg       60

tagggaacct ctttgtgctt gactttgcac acacacggga tcttcagggt gggtacattt      120

aaaactgaca agtattgcca aattgccccc caacgtagtt tttacacccc acctactact      180

ctcagtgaaa aatcaggccc tttttatttt aagggctaaa ttgctaatcc ctgtgtgaaa      240

atgggtgtta acaaaataaa aaataaggaa aatatgcagg cttacccaat tttgttatct      300

atacatttta cagtctctaa tacttagcat agctcctttg ggtgtctgcc caccaccctt      360

ctttctgaac gtggggttcc ctgggctttc cttgtttgac ttcagacctg gatctaatag      420

ggatctggag gtagaatcaa gacgaatgtt ccctttggcc ttaggtgagt cctttgcatc      480

tctgaggccc tgttgatgac atccagttct ctagacctct gcccaaacca gagcaatccc      540

tcctcaaata tgctaagcag aaatgcagac aatataagac acactatatt tatattttag      600

gagtttacat taccttccct tctgtttgga aaccaacatc tctcaaaatt aggtatagtt      660

aacacagaat accccaaaat accaccattc ttcataattc catttcctta tttctggatt      720

ctttcaaggg taaaaacctt gtttcattca tctttggggc agcatttgcc tagtatgtgg      780

taggcgccca gtagattttg gataaactga cctgattttc tgttaatatt ccaactggat      840

tatttctttc tcctcttaca gaatgaagat attcaaatgt tattttaaac ataccctaca      900

gcagaaagtt ttcatcctgt ttttaaccct atggctgctc tctttgttaa agcttctaaa      960

tgtgagacga ctctttccgc aaaaagacat ttacttggtt gagtactccc taagtacctc     1020

gccttttgta agaaacagat acactcatgt taaggatgaa gtcaggtatg aagttaactg     1080

ttcgggtatc tatgaacagg agcctttgga aattggaaag agtctggaaa taagaagaag     1140

ggacatcatt gacttggagg atgatgatgt tgtggcaatg accagtgatt gtgacattta     1200

tcagactcta agaggttatg ctcaaaagct tgtctcaaag gaggagaaaa gcttcccaat     1260

agcctattct ttggttgtcc acaaagatgc aattatggtt gaaaggctta tccatgctat     1320

atacaaccag cacaatattt actgcatcca ttatgatcgt aaggcacctg ataccttcaa     1380

agttgccatg aacaatttag ctaagtgctt ctccaatatt ttcattgctt ccaaattaga     1440

ggctgtggaa tatgcccaca tttccagact ccaggctgat ttaaattgct tgtcggacct     1500

tctgaagtct tcaatccagt ggaaatatgt tatcaacttg tgtgggcaag attttcccct     1560

gaagtcaaat tttgaattgg tgtcagagtt gaaaaaactc aatggagcaa atatgttgga     1620

gacggtgaaa cccccaaaca gtaaattgga aagattcact taccatcatg aacttagacg     1680

ggtgccttat gaatatgtga agctaccaat aaggacaaac atctccaagg aagcaccccc     1740

ccataacatt cagatatttg ttggcagtgc ttattttgtt ttaagtcaag catttgttaa     1800

atatattttc aacaactcca tcgttcaaga cttttttgcc tggtctaaag acacatactc     1860

tcctgatgag cacttttggg ctaccttgat tcgggttcca ggaatacctg gggagatttc     1920

cagatcagcc caggatgtgt ctgatctgca gagtaagact cgccttgtca agtggaatta     1980

ctatgaaggc tttttctatc ccagttgtac tggatctcac cttcgaagcg tgtgtattta     2040

tggagctgca gaattaaggt ggcttatcaa agatggacat tggtttgcta ataaatttga     2100

ttctaaggtg gaccctatct tgattaaatg cttggcagaa aagcttgaag aacagcagag     2160

agactggatc actttgccct cagaaaagtt atttatggat agaaatctca ctaccacatc     2220

atgatagtaa aatcaggatg gaaataagag ggtgcctgat aaatggagtc agtgtggaat     2280

tgaataccat actatgccca atactgttta aactcagtcc tcccatattt taaaaggtgt     2340

ccaaaattcc atacacaagg gaaagtgatc tagcctttga tgttattagc ctgcagttgg     2400

ctaggttttt ttaatatttg tttttgcttg taatctcact gagccaaatc agagatctta     2460

aacattcagt cagtcatcaa acattattga gcacctaact atatgacagg cactttttta     2520

gagactgcgg cttatcctca tcatagcaac ctcggtatct ttaagttctc cacataacag     2580

tcaggattct actgaagaag cttttgaagt ttgtggtaat cgtctgatca tataaaccac     2640

ccatttcaga gtagtgttta agtactgtga ccaacactcc acttgtctct taactcagct     2700

ttcaagacat ttcttaacca tcagagcaga ggaggaaaga ctcactacct cagaaaaatc     2760

tcaaagaata gtccaatttc ctgcttgcca aagcataatc tgccttttgg tgcattactt     2820

ggtcaattca gggttgagga gactgttggg gggcatttat aatgtatgaa agttaaggaa     2880

gggggtgagg atgtgggttg ggacaggtag tacctaaaga ggagcgaagg gatttataca     2940

acatttttat catgttacaa aacagtatca tgaatggcct cctttttagt tcaactgttt     3000

ctttaaaatg catttactga ttaaaaataa gaactgacca atagctccaa gtgtcacaca     3060

ccagaacatt aagcctaagt cctcaattca taagttatca ttctagataa gtttctttac     3120

aatggaatac tttctgtgga atcattataa ttctgttgta tggaactatc aagctaagag     3180

tcactaaact ttcttcaaaa ggttgtgtga aatatgacag ctttctaaat taatttgtat     3240

agtcatttaa aattttttct tctctggcaa ctgtccaact ggaatccaga tttaaagtga     3300

taaaagctct aagtttcttg cagtcttttt ctcagcttag ttccagagag aaaaaagcta     3360

attttcctaa ggacacagca agaatattca ttaaggatat tttctaaaac ccacacttga     3420

gaaaaccacc caatga                                                     3436


<210>  36
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Lys Ile Phe Lys Cys Tyr Phe Lys His Thr Leu Gln Gln Lys Val 
1               5                   10                  15      


Phe Ile Leu Phe Leu Thr Leu Trp Leu Leu Ser Leu Leu Lys Leu Leu 
            20                  25                  30          


Asn Val Arg Arg Leu Phe Pro Gln Lys Asp Ile Tyr Leu Val Glu Tyr 
        35                  40                  45              


Ser Leu Ser Thr Ser Pro Phe Val Arg Asn Arg Tyr Thr His Val Lys 
    50                  55                  60                  


Asp Glu Val Arg Tyr Glu Val Asn Cys Ser Gly Ile Tyr Glu Gln Glu 
65                  70                  75                  80  


Pro Leu Glu Ile Gly Lys Ser Leu Glu Ile Arg Arg Arg Asp Ile Ile 
                85                  90                  95      


Asp Leu Glu Asp Asp Asp Val Val Ala Met Thr Ser Asp Cys Asp Ile 
            100                 105                 110         


Tyr Gln Thr Leu Arg Gly Tyr Ala Gln Lys Leu Val Ser Lys Glu Glu 
        115                 120                 125             


Lys Ser Phe Pro Ile Ala Tyr Ser Leu Val Val His Lys Asp Ala Ile 
    130                 135                 140                 


Met Val Glu Arg Leu Ile His Ala Ile Tyr Asn Gln His Asn Ile Tyr 
145                 150                 155                 160 


Cys Ile His Tyr Asp Arg Lys Ala Pro Asp Thr Phe Lys Val Ala Met 
                165                 170                 175     


Asn Asn Leu Ala Lys Cys Phe Ser Asn Ile Phe Ile Ala Ser Lys Leu 
            180                 185                 190         


Glu Ala Val Glu Tyr Ala His Ile Ser Arg Leu Gln Ala Asp Leu Asn 
        195                 200                 205             


Cys Leu Ser Asp Leu Leu Lys Ser Ser Ile Gln Trp Lys Tyr Val Ile 
    210                 215                 220                 


Asn Leu Cys Gly Gln Asp Phe Pro Leu Lys Ser Asn Phe Glu Leu Val 
225                 230                 235                 240 


Ser Glu Leu Lys Lys Leu Asn Gly Ala Asn Met Leu Glu Thr Val Lys 
                245                 250                 255     


Pro Pro Asn Ser Lys Leu Glu Arg Phe Thr Tyr His His Glu Leu Arg 
            260                 265                 270         


Arg Val Pro Tyr Glu Tyr Val Lys Leu Pro Ile Arg Thr Asn Ile Ser 
        275                 280                 285             


Lys Glu Ala Pro Pro His Asn Ile Gln Ile Phe Val Gly Ser Ala Tyr 
    290                 295                 300                 


Phe Val Leu Ser Gln Ala Phe Val Lys Tyr Ile Phe Asn Asn Ser Ile 
305                 310                 315                 320 


Val Gln Asp Phe Phe Ala Trp Ser Lys Asp Thr Tyr Ser Pro Asp Glu 
                325                 330                 335     


His Phe Trp Ala Thr Leu Ile Arg Val Pro Gly Ile Pro Gly Glu Ile 
            340                 345                 350         


Ser Arg Ser Ala Gln Asp Val Ser Asp Leu Gln Ser Lys Thr Arg Leu 
        355                 360                 365             


Val Lys Trp Asn Tyr Tyr Glu Gly Phe Phe Tyr Pro Ser Cys Thr Gly 
    370                 375                 380                 


Ser His Leu Arg Ser Val Cys Ile Tyr Gly Ala Ala Glu Leu Arg Trp 
385                 390                 395                 400 


Leu Ile Lys Asp Gly His Trp Phe Ala Asn Lys Phe Asp Ser Lys Val 
                405                 410                 415     


Asp Pro Ile Leu Ile Lys Cys Leu Ala Glu Lys Leu Glu Glu Gln Gln 
            420                 425                 430         


Arg Asp Trp Ile Thr Leu Pro Ser Glu Lys Leu Phe Met Asp Arg Asn 
        435                 440                 445             


Leu Thr Thr Thr Ser 
    450             


<210>  37
<211>  2178
<212>  DNA
<213>  Homo sapiens

<400>  37
ccgcagcccg cccgagccgc gtcagggcag aggcggggtg gggcgcggtt aaaaggcgca       60

gcaggtggga gccggggcct tcacccgaaa cccgacgaga gcccgacagc cggcggcgcc      120

cgagcccgac ctgcctgccc agccggagcg aagggcgccg ccccgcgcag agcccgcgcc      180

agggccgccg gccgcagagc agttaaaacg tgcaggcacc agaaggcact tcctgtcggt      240

gaagaagacc tgtctccggt gtcacgggca tcctgtgttt tgcaaacggg gctgacctcc      300

cttcctgggg agcaggaagg gtcagggaag gaaaagaagt acagaagatc tggctaaaca      360

atttctgtat ggcgaaagaa aaattctaac ttgtacgccc tcttcatgca tctttaattc      420

aatttgaata ttccaggcga catcctcact gaccgagcaa agattgacat tcgtatcatc      480

actgtgcacc attggcttct aggcactcca gtggggtagg agaaggaggt ctgaaaccct      540

cgcagaggga tcttgccctc attctttggg tctgaaacac tggcagtcgt tggaaacagg      600

actcagggat aaaccagcgc aatggattgg gggacgctgc acactttcat cgggggtgtc      660

aacaaacact ccaccagcat cgggaaggtg tggatcacag tcatctttat tttccgagtc      720

atgatcctcg tggtggctgc ccaggaagtg tggggtgacg agcaagagga cttcgtctgc      780

aacacactgc aaccgggatg caaaaatgtg tgctatgacc actttttccc ggtgtcccac      840

atccggctgt gggccctcca gctgatcttc gtctccaccc cagcgctgct ggtggccatg      900

catgtggcct actacaggca cgaaaccact cgcaagttca ggcgaggaga gaagaggaat      960

gatttcaaag acatagagga cattaaaaag cagaaggttc ggatagaggg gtcgctgtgg     1020

tggacgtaca ccagcagcat ctttttccga atcatctttg aagcagcctt tatgtatgtg     1080

ttttacttcc tttacaatgg gtaccacctg ccctgggtgt tgaaatgtgg gattgacccc     1140

tgccccaacc ttgttgactg ctttatttct aggccaacag agaagaccgt gtttaccatt     1200

tttatgattt ctgcgtctgt gatttgcatg ctgcttaacg tggcagagtt gtgctacctg     1260

ctgctgaaag tgtgttttag gagatcaaag agagcacaga cgcaaaaaaa tcaccccaat     1320

catgccctaa aggagagtaa gcagaatgaa atgaatgagc tgatttcaga tagtggtcaa     1380

aatgcaatca caggtttccc aagctaaaca tttcaaggta aaatgtagct gcgtcataag     1440

gagacttctg tcttctccag aaggcaatac caacctgaaa gttccttctg tagcctgaag     1500

agtttgtaaa tgactttcat aataaataga cacttgagtt aactttttgt aggatacttg     1560

ctccattcat acacaacgta atcaaatatg tggtccatct ctgaaaacaa gagactgctt     1620

gacaaaggag cattgcagtc actttgacag gttcctttta agtggactct ctgacaaagt     1680

gggtactttc tgaaaattta tataactgtt gttgataagg aacatttatc caggaattga     1740

tacgtttatt aggaaaagat atttttatag gcttggatgt ttttagttct gactttgaat     1800

ttatataaag tatttttata atgactggtc ttccttacct ggaaaaacat gcgatgttag     1860

ttttagaatt acaccacaag tatctaaatt tggaacttac aaagggtcta tcttgtaaat     1920

attgttttgc attgtctgtt ggcaaatttg tgaactgtca tgatacgctt aaggtggaaa     1980

gtgttcattg cacaatatat ttttactgct ttctgaatgt agacggaaca gtgtggaagc     2040

agaaggcttt tttaactcat ccgtttgcca atcattgcaa acaactgaaa tgtggatgtg     2100

attgcctcaa taaagctcgt ccccattgct taagccttca aaaaaaaaaa aaaaaaaaaa     2160

aaaaaaaaaa aaaaaaaa                                                   2178


<210>  38
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asp Trp Gly Thr Leu His Thr Phe Ile Gly Gly Val Asn Lys His 
1               5                   10                  15      


Ser Thr Ser Ile Gly Lys Val Trp Ile Thr Val Ile Phe Ile Phe Arg 
            20                  25                  30          


Val Met Ile Leu Val Val Ala Ala Gln Glu Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Glu Asp Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Lys Asn Val Cys 
    50                  55                  60                  


Tyr Asp His Phe Phe Pro Val Ser His Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


Tyr Tyr Arg His Glu Thr Thr Arg Lys Phe Arg Arg Gly Glu Lys Arg 
            100                 105                 110         


Asn Asp Phe Lys Asp Ile Glu Asp Ile Lys Lys Gln Lys Val Arg Ile 
        115                 120                 125             


Glu Gly Ser Leu Trp Trp Thr Tyr Thr Ser Ser Ile Phe Phe Arg Ile 
    130                 135                 140                 


Ile Phe Glu Ala Ala Phe Met Tyr Val Phe Tyr Phe Leu Tyr Asn Gly 
145                 150                 155                 160 


Tyr His Leu Pro Trp Val Leu Lys Cys Gly Ile Asp Pro Cys Pro Asn 
                165                 170                 175     


Leu Val Asp Cys Phe Ile Ser Arg Pro Thr Glu Lys Thr Val Phe Thr 
            180                 185                 190         


Ile Phe Met Ile Ser Ala Ser Val Ile Cys Met Leu Leu Asn Val Ala 
        195                 200                 205             


Glu Leu Cys Tyr Leu Leu Leu Lys Val Cys Phe Arg Arg Ser Lys Arg 
    210                 215                 220                 


Ala Gln Thr Gln Lys Asn His Pro Asn His Ala Leu Lys Glu Ser Lys 
225                 230                 235                 240 


Gln Asn Glu Met Asn Glu Leu Ile Ser Asp Ser Gly Gln Asn Ala Ile 
                245                 250                 255     


Thr Gly Phe Pro Ser 
            260     


<210>  39
<211>  444
<212>  DNA
<213>  Homo sapiens

<400>  39
atggacacac tttgctacac actcctgctg ctgaccaccc cttcctgtga gtgctgtggt       60

cagggacttc ctcagaagtg aaacatcagt tgtctccttt gtgggcttca tcttcttatg      120

tcttctccac aggggtcttg tcccaggtca ccttgaagga gtctggtcct gtgctggtga      180

aacccacaga gaccctcacg ctgacctgca ccgtctctgg gttctcactc agcaatgcta      240

gaatgggtgt gagctggatc cgtcagcccc cagggaaggc cctggagtgg cttgcacaca      300

ttttttcgaa tgacgaaaaa tcctacagca catctctgaa gagcaggctc accatctcca      360

aggacacctc caaaagccag gtggtcctta ccatgaccaa catggaccct gtggacacag      420

ccacatatta ctgtgcacgg atac                                             444


<210>  40
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Asp Thr Leu Cys Tyr Thr Leu Leu Leu Leu Thr Thr Pro Ser Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys 
            20                  25                  30          


Pro Thr Glu Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Asn Ala Arg Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala His Ile Phe Ser Asn Asp Glu Lys Ser Tyr 
65                  70                  75                  80  


Ser Thr Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Ser Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile 
        115                 


<210>  41
<211>  1201
<212>  DNA
<213>  Homo sapiens

<400>  41
agttagccca gggaggaagg ggacagaatg acagcatggt tatatcaatg gtccaattct       60

tggttccaac ccttgattgt ccttcgagag caccacccat tccttacaac acatctctcc      120

gcttcatttt gggagttttg aagttattaa agttattgat ttcttttcct tacaaccaaa      180

ataatctaaa ttaagattgt ggccaagttt ggattaaaac ctgcctcccg gctccaagac      240

ccatgttttt ctatcatgct gactggcagc aaagacgtct tcccatggat ttttcagaac      300

tctgttcttt aaatgtgacc ttagatgcac cagactcatg ccatccaaag gttggaggta      360

ctgcccagtt ttagcaatga aagtcccacg tcacgggaaa cctctgagtc ctggacaaat      420

caagatgaca ttttctatgc atatgcaagc atgtcaccag gagcagagca cagagggaca      480

acacagcttt tgcgcttcca gctggctccc atcaagaagt tagaagggag cctgcaaaca      540

catttcctgc tatcatctct ccaccccaga atgactttcc ctggtagagc tgggggaggg      600

gaggcgggca gcaggccccc caggaggccc tgggcaggaa tattaatact ccaacttccc      660

agcacaagag gagggaggag gagcggccac ggcgcagtcc ggtcctgggg gccctggaag      720

gtggttgctg agcagcccgt gggaggcacg gatccgccag ctcacggcgg caggggccgc      780

ccaagtccta atgaaaacac ctagctcctg gcagggcgca gccgacacat cgccctgcct      840

tctcggccac ctgggagagg atgggcgccg cacgcggata cccaacctgc cgggttgtgc      900

tcgcagtgac atcgcttttc tcccggcaag tgcatccatc tcgctgggtc tggatagata      960

acacaatctc tctgcccaca ccccatttgc tgggagacag cctgggcttc tccatttttt     1020

atgggctcac ttagcttgga ggaaatccag aggtcaaagc cggcgcagac gctccagtca     1080

ccttgcccgt ccgggcgcgc agccattccg aaacgggctc acccacgggg ccctaaatta     1140

cggcgattac actgcaattc gcagcgcgat attactttga tacactacct gctgcagctt     1200

g                                                                     1201


<210>  42
<211>  4526
<212>  DNA
<213>  Homo sapiens

<400>  42
ggaagacaac ctaggcaata ccattctgaa caattgctct ttcaagaggc ttagttgtga       60

gtggtgcagc aagatgagtg gaagcaagct tcttttcttt ttccttttct tccttccttt      120

cttaatgggg aagatttaaa tgtgttcata gtcctggggg aaggtgcctg gggagagaga      180

ggttgaagga gaagaaaagc gagagcagtg tttctgcaga aatagaatgg gactgagaac      240

cagacactga tgggggcttg catttggaaa caaggaaaat aagcaagggt ggagttgtag      300

taccattttg tattatatgt ctcataaccc tagtatctga actctctgtg atcagacttt      360

gctgcctgtg gacttttcta cgtattgatt ttagtgtctt gttccttgtg tattatgtga      420

tttttttaaa gctgtaaact gcttactttc cttggaaatt tgtgggaatt ctttgagtcc      480

ttagttgaga ttttattcct ccagagagga ttttctttgc cttctgcaaa tcatctcaag      540

gcagtaccat agtgttaatt cagacaacaa atccatttga aggctggctt gtggtgacaa      600

ggtctcaggg gagattttcc ccactccaac accaagtcca aaacgtatac atttctttgt      660

cgtcttttgc atgatgggtt tatttcttgt ctactcttcc cttgagggtg tatcctttgg      720

gaggaggtac caggtttggg tgaggtctcc taatacactg tctatattaa tggcatttta      780

ggctttactt cacaaacccc aagcggttgc agctgtcgaa accgaaaccc agggcaaaag      840

gtggctttgg tgcctgctta cttcgagttc ttgctttcac ttcattttgg cctttgtaga      900

ttctcttcct tttgtgctag ctcaacgatg tggttttatt tttacattct tacatatttt      960

atccagggtc ttagtttcag tcgagaaggt agttcaggat atcaaatctg ccctactgct     1020

agaaaaggaa gcccggtgtg cctgctatcg taactttggt tttgataagc aaacacgagc     1080

agtttttgac tgctgggttt acagcatagg aaccctgttg ctatgcagct gttgttggaa     1140

aatagtctgt gggctcagag tttctaaacc aaccgtctat tggatgccca gagaaggaag     1200

gaaagcgagg gccctggctt gctgattaca aaccatctcc atggtcacag gttgctgggt     1260

gctcctttta cgatgttttc ccagcagcat gcaggcagca gtagcttcct ttgatcattt     1320

ttcagtttct gttatttgct agtgagagaa agtttatacc tgcttgtggg gacatgagtg     1380

aagaaagaga ggggactttg aaacaagaga agagagcaaa ctcaaaaggt ttttcatggc     1440

agcatgtgac aagatgatgc tgaaaaattt atatggaaat tcaaaggatc aagaatagct     1500

gaaacatcac tgaagaagaa caaagtgggc tgaactcgct ctactagata tcaagattta     1560

taagcaacta cagtatttag gacagtgtag tatcggcact gggagagaaa aaaaaaaaaa     1620

aaaactaaaa ggaaaaagag cccagagact gacttttgtg tatgtggaca gtttgtttat     1680

gatgaaagta ccactgctat gcactgtggg aaaatgtcct caaagaatga cactagggca     1740

actgggtatc cccatgtaaa aacaattaac cctaatctca catcacacac aaaaatcaac     1800

tccatttggg gtatatactt aaatggaagg taaaactatt aatataaagt ttatagagaa     1860

tattgtttat tgcttttttg gccccgattc ttctctcctc cctgtgccca tgccctttcc     1920

caggtgactt tgcagttcct ctcataaaag gggcagatta tgtttttcct ccctggactc     1980

tatgtttggc ttaagtcctt tggtggaagt gacagtgtgc cattctgggc ctaggcctca     2040

agggaccttg aacatctctg cttgccctct tccacttatg ccatccccat gagaaggata     2100

tgcctgatcc agcccactga ccttgacagg gagatgagag acacatgggt agagttctct     2160

ggtgaagctg ccccagccaa acccagcctg gagccaagcc cagccaagat aaagtgagcc     2220

catcctggac cagctgaccc aggcacctga atgagaacaa aataattttt gttttccatc     2280

attgagcttt gggtacattt gttaggcagc aataaactaa catcagaagg taatatagga     2340

aaatatctat atgacttcca gataggcaaa tgtgttttaa gctagtcaca aaagtacctg     2400

ctcaccataa agaaaaagag tttttatgtt aaaattaaga atcctcattt atcagaaaat     2460

actgttaaga gagtaaagag gcttgccata aaatggaaga tgatatttgc aaccattcaa     2520

caaaaaacca gtatcgagaa tattttaaaa attcctacac agaattaaga aaagacagat     2580

tattttacat tttatataaa agtccatcca ccttttatat gtacctgttg cacataaaaa     2640

tgagcaaaaa gacttgaaag agtattttgc aaaagagtaa atccacctgg acaataaaca     2700

tacgataatg ttctgaatcc cagaaaccag ggaaatgtag attaaagtca acaacaaagt     2760

ggtagcttag accccaagat taaaacagtg tcagtgagaa aataccagtt acagagatag     2820

tcaggaacct ttaagaaaca agatgctgga tgttacattg aaaaatatgt gctgagctgt     2880

gctgctctgt aactacctgc cctgttgtga atctgaccca caatgcctgt gagagtggtg     2940

ttttctctgg aggattcaaa ggaaaggaca gttgccttct tccttgtgtt gctacagggc     3000

agagagaata ctgcaggagg tgaggggcag aacagagttt ataacctcaa ctgcagtgtg     3060

aaaatgctgg ttacctccac catgtcttac ggtgtagcag ccatatgttt tgagttgggt     3120

agatcccaac caccttcagg gataagccct gattgcccta agccattcat cataatccca     3180

tttccctggc cttggatggc tatataacct acattgattc aatcagactg aggttctgga     3240

ctcttgctca gtattaaaca catgtatgac ctagaagtgc tgcagccatt ttgctactac     3300

gaggaaccca gtctgaagac aaattgtgta caagggaagg ggcagagcca agagaattat     3360

ggaatgaaat ccagtttgat tagatcatgc ctgaaatttt ctaattacta cacctttcag     3420

ttatatgaac caatgaattt cctttatttt tcaagccagt ttgagttggc tttctgctag     3480

ttgcaataga agcatctgta gaaattagag caacaggtga tgaggaaaga tgtactgaaa     3540

tttccgcagg atctggtgat gaggagaagc acaagttata ccaccaaata tggaatggag     3600

gcttaatagg tttaaaaata atattaaggg ggaagtttga ctgaggaact ctggcaaatg     3660

ccacttgact gacacatatg atatctagta gcttagtgaa gtttagggat ggttccttga     3720

gagaatcaac tagaaagcct tttaaaactc ctttgaagag aatataagct cttgaaaaga     3780

tcccaaagat caatcatttc atcaaacagc tggggaaact gaggcccaaa gaggttatgt     3840

tttagttagt acttaagatg gggccaggtc ctgggtgtcc agatttctca tgagggttct     3900

atcaactcat gaaagctcat catcttagat gtgtataatg aaaaactttc attttcatct     3960

actcacattg aatctcattg actctatttt ttcttcctca cccagctcta aagatctttt     4020

aggaatttag cagaaaatag gtaactgtca gtcaaattta ccatcacttg ctgatgtggg     4080

gaattcctgg ggtgccccat gtccagatca gttatgtaag ccctgagtga gattcatctg     4140

tcacaggctc attgcctcct tagctcctgg tggtttgaag cttcccttgg atttggcatc     4200

ttgtcctggg ttcttgctcc tactctcctt ggggttcagt tctctctcct ggattttgag     4260

cacagtggca ccaactccct tattcctggt gcaggtggag ccggctctgg ctgtggtcgt     4320

ggattctgcc atgatctctc caggtcctac ctgagaattt gatagtcctt gacttttctc     4380

tttttacccc caacatggct ttgtcaagcc ctgggattct atctgatgtc taccaccttt     4440

cttgtcttta aaccactctt tcaatcccca cctcattatc ttttgcctgg accattacaa     4500

tagttactaa aggccctaaa ccaaaa                                          4526


<210>  43
<211>  103
<212>  DNA
<213>  Homo sapiens

<400>  43
gagtcagaat tctcatcagg ctgtgatgct cagttgtgtg tagattgaaa gccctaattt       60

tacacacaac tgaggatcat agcctgatgg ttcctttttg ttt                        103


<210>  44
<211>  80
<212>  DNA
<213>  Homo sapiens

<400>  44
ggtacttgaa gagtggttat ccctgctgtg ttcgcttaat ttatgacgaa tcatacaggg       60

acatccagtt tttcagtatc                                                   80


<210>  45
<211>  94
<212>  DNA
<213>  Homo sapiens

<400>  45
actgatatat ttgtcttatt tgagagctga ggagtatttt tatgcaatct gaatgatctc       60

agctgtctga aaatgtcttc aattttaaag gctt                                   94


<210>  46
<211>  1036
<212>  DNA
<213>  Homo sapiens

<400>  46
cccaaaccca ttccacctta ctaccaaaca accttaacca aaccatttac tcaaataaag       60

tataggcgat agaaattgta aaccggcgca atagatatag taccgcaagg gaaagatgaa      120

aaattataac caagcataat atagcaagga ctaacccctg taccttctgc ataatgaatt      180

aactagaaat aactttgcaa agagaaccaa agctaagacc cccgaaacca gacgagctac      240

ctaagaacag ctaaaagagc atacccgtct atgtagcaaa atagtgggaa gattcatagg      300

tagaggcgac aaacctaccg agtctggtga tagctggttg tccaagatag aatcttagtt      360

caactttaaa tttacccaca gaaccctcca aatccccctg taaatttaac tgttagtcca      420

aagaggaaca gctctttgga cactaggaaa aaaccttgta aagagagtaa aaaatttaat      480

acccatagta ggcctaaaag cagccaccaa ttaagaaagc gttcaagctc aacacctatc      540

atccgaaaaa tcccaaacat atgactgaac tccttgcacc caattggacc aatctattac      600

cttatagaag aactaacgtt ggtataagta acatgaaagc attctcctcc acataagcct      660

acatcagacc aaaatattaa actgacaatt aacagcctaa tatctacaac caaccaacaa      720

gccattatta cccccactgt taacccaaca caggcatgcc cacaaggaaa ggttaaaaaa      780

agtaaaagga actcggcaaa ccttacccca cctgtttacc aaaaacatca cctctagcat      840

tatcagtatt agaggcaccc ctgcccggtg acatatgttt aacggccgcg gtaccctaac      900

cgtgcaaagg tagcataatc acttgttcct taaataggga cttgtatgaa tggctccacg      960

agggttcagc tgtctcttac tttcaaccag tgaaattgac ctgcccgtga agagactttt     1020

aagttcagtt ttttaa                                                     1036


<210>  47
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Pro Arg Gly Phe Ser Cys Leu Leu Leu Ser Thr Ser Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Leu Leu Ser Ser Val Phe 
            20                  25              


<210>  48
<211>  1019
<212>  DNA
<213>  Homo sapiens

<400>  48
ggttgagccg ggtagggaaa gcagcctaaa gcccgggaca ggcacacagg cccaggtgtg       60

taggccacag cagccgcagt cctgaaaggc tgcaacaccc agacctccag gagagaccag      120

gcccaggatg cctcgcctgt tcttgttcca cctgctagaa ttctgtttac tactgaacca      180

attttccaga gcagtcgcgg ccaaatggaa ggacgatgtt attaaattat gcggccgcga      240

attagttcgc gcgcagattg ccatttgcgg catgagcacc tggagcaaaa ggtctctgag      300

ccaggaagat gctcctcaga cacctagacc agtggcagaa attgtaccat ccttcatcaa      360

caaagataca gaaactataa ttatcatgtt ggaattcatt gctaatttgc caccggagct      420

gaaggcagcc ctatctgaga ggcaaccatc attaccagag ctacagcagt atgtacctgc      480

attaaaggat tccaatctta gctttgaaga atttaagaaa cttattcgca ataggcaaag      540

tgaagccgca gacagcaatc cttcagaatt aaaatactta ggcttggata ctcattctca      600

aaaaaagaga cgaccctacg tggcactgtt tgagaaatgt tgcctaattg gttgtaccaa      660

aaggtctctt gctaaatatt gctgagatga agctaattgt gcacatcttg tctaattttc      720

acacatagtc ttgatgacat ttcactgatg cttctgtcag gtcccactaa ttattagaat      780

ataagaaatc tttattaatg tttagatttt tcatttggtg tgtaagaaaa tattctttgt      840

atgattgtag tttctgtaaa tgacactttc tatgctgaag tctttttgtc tttttattaa      900

cagtataatt gtgttgattc tttttaatgc tgttaactta aaattacaat aaaacctttg      960

ccactttaac catacataat aacaatacag tacctaacaa cagtaaaaaa aaaaaaaaa      1019


<210>  49
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Pro Arg Leu Phe Leu Phe His Leu Leu Glu Phe Cys Leu Leu Leu 
1               5                   10                  15      


Asn Gln Phe Ser Arg Ala Val Ala Ala Lys Trp Lys Asp Asp Val Ile 
            20                  25                  30          


Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile Cys Gly 
        35                  40                  45              


Met Ser Thr Trp Ser Lys Arg Ser Leu Ser Gln Glu Asp Ala Pro Gln 
    50                  55                  60                  


Thr Pro Arg Pro Val Ala Glu Ile Val Pro Ser Phe Ile Asn Lys Asp 
65                  70                  75                  80  


Thr Glu Thr Ile Ile Ile Met Leu Glu Phe Ile Ala Asn Leu Pro Pro 
                85                  90                  95      


Glu Leu Lys Ala Ala Leu Ser Glu Arg Gln Pro Ser Leu Pro Glu Leu 
            100                 105                 110         


Gln Gln Tyr Val Pro Ala Leu Lys Asp Ser Asn Leu Ser Phe Glu Glu 
        115                 120                 125             


Phe Lys Lys Leu Ile Arg Asn Arg Gln Ser Glu Ala Ala Asp Ser Asn 
    130                 135                 140                 


Pro Ser Glu Leu Lys Tyr Leu Gly Leu Asp Thr His Ser Gln Lys Lys 
145                 150                 155                 160 


Arg Arg Pro Tyr Val Ala Leu Phe Glu Lys Cys Cys Leu Ile Gly Cys 
                165                 170                 175     


Thr Lys Arg Ser Leu Ala Lys Tyr Cys 
            180                 185 


<210>  50
<211>  4796
<212>  DNA
<213>  Homo sapiens

<400>  50
ctgcgcagtc tgaggcgtcc ctcgcgtcgg gtggaagagc ggctgcgcaa caagtgaacc       60

tatggattaa ggtgtagccg ggcggcccgg aggttgagag tgcaagatta ttctgcgcct      120

gcgcggcccg ggtaactttg ctggctgctc ctaggctccc ggctcgccgc catcttgtat      180

tggggtttca ttgttcccgc tgggccgggc ggtttagtgt aattgccgcc ggaggaggag      240

gcggagtaac ctctggtcag ccgagaaacc ccactatcct gtagccataa ccgcttaaac      300

gatttgggag gtagtgaagg gcagggagct ggacctggag gcgccgccgc gacagcagca      360

gccatggagg acgagatgcc caagactcta tacgtcggta acctttccag agatgtgaca      420

gaagctctaa ttctgcaact ctttagccag attggacctt gtaaaaactg caaaatgatt      480

atggatacag ctggaaatga tccctattgt tttgtggagt ttcatgagca tcgtcatgca      540

gctgcagcat tagctgctat gaatggacgg aagataatgg gtaaggaagt caaagtgaat      600

tgggcaacaa cccctagcag tcaaaagaaa gatacaagca gtagtaccgt tgtcagcaca      660

cagcgttcac aagatcattt ccatgtcttt gttggtgatc tcagcccaga aattacaact      720

gaagatataa aagctgcttt tgcaccattt ggaagaatat cagatgcccg agtggtaaaa      780

gacatggcaa caggaaagtc taagggatat ggctttgtct cctttttcaa caaatgggat      840

gctgaaaacg ccattcaaca gatgggtggc cagtggcttg gtggaagaca aatcagaact      900

aactgggcaa cccgaaagcc tcccgctcca aagagtacat atgagtcaaa taccaaacag      960

ctatcatatg atgaggttgt aaatcagtct agtccaagca actgtactgt atactgtgga     1020

ggtgttactt ctgggctaac agaacaacta atgcgtcaga ctttttcacc atttggacaa     1080

ataatggaaa ttcgagtctt tccagataaa ggatattcat ttgttcggtt caattcccat     1140

gaaagtgcag cacatgcaat tgtttctgtt aatggtacta ccattgaagg tcatgttgtg     1200

aaatgctatt ggggcaaaga aactcttgat atgataaatc ccgtgcaaca gaatcaaatt     1260

ggatatcccc aaccttatgg ccagtggggc cagtggtatg gaaatgcaca acaaattggc     1320

cagtatatgc ctaatggttg gcaagttcct gcatatggaa tgtatggcca ggcatggaac     1380

cagcaaggat ttaatcagac acagtcttct gcaccatgga tgggaccaaa ttatggagtg     1440

caaccgcctc aagggcaaaa tggcagcatg ttgcccaatc agccttctgg gtatcgagtg     1500

gcagggtatg aaacccagtg aataaggact ccagaatcta aagccagtgg cttgaggcta     1560

cagggagtgt agtaaagccg ttgtttactt aaagatttat caaatcagtc agtgcaaatg     1620

tcagatacaa tgtatttatt taaaagattc atttttaatc atgaaattac ttatcatcca     1680

cattgtttta aaaagaaaca agatgctgga tgtctgccaa tttttgcctt cattaccttt     1740

tttgataaag tttctcagat ccttgtttca aacacaaatg cagggattgc tgccactttt     1800

taactattaa gaggcagaaa attgcacaat attgaacttt tttccactga agtagtgtgc     1860

agttctagtt tgcattcctg atatgattta aaacatgtaa tataaagatg ttaaaaaaaa     1920

aaaccaaaac tgtgcagagt ctagaagttg tttgtcatct tcagcttgtg cacaattctg     1980

ttttaggtta aaaaaaggca ttgtttgagc tgtcccatct ccactgttat ccctttgggg     2040

ttttttaata taaattatta gtttacatca tttttgtatc tacatctttt ttcacaaatt     2100

tgtcttgcct tattaaagtt ctgtaaaata tacttaaatg gaaaaaatga tgttcattta     2160

gattgaaaac ttttctcaga tggattgata attgcattca tcttgtgttt tatatgagaa     2220

ggtgcctcaa gaatttcctg ttggatttgt ttaaaaggat ttttatcttt cgtgataaac     2280

tttgctgtgt accaggaact ataaaaacaa aaacttgtta ctaaagaaaa tatctgaaat     2340

gtgataagtt cttatgccat gttaatttca tgtgtcaact tcaacattta catgtattat     2400

ttcattatgt aaaatgtttt agcaatttaa tattttgcac agttagcaaa ctttgtatgt     2460

catttccttc aaggcatcat gcagagttga catgagattt ataaggtttt aagttgtttg     2520

catgtgaaaa tcaaatacat actttggtag tctttgaata caaagtcatc tgctcttgtt     2580

tttcaagaat tttgagacac aaagttgtat gtaaaggaat atattaattt gccgttttct     2640

aggtagattt gctcaaaaag agtgaatcaa cttaatatgt acaaatgata gctgtgaaac     2700

tgtagaatat ctttgtgtca ggcttggagt tcattgtgac ctccaaattt tgcctgaagg     2760

accagctggg caaagcatct tttaaatgtt cagaggccaa aagataaaca aaaaaaaaac     2820

cttaaaatcc tacctcttta aacagccttc agataagaga atcctcagtg caatcattat     2880

tttgattcgt ttggtacctg ttttcctgga gttcccgatt ttattatttt ggggtggctc     2940

caagcattaa gaggtttaat ctttgatggc attgttctag ttttgaaatt tctagtatat     3000

ttcagagtct cttagaagac ttgtgtggga agtttcactt tgttttcagt gaagatcaca     3060

aacctccttc ttcctttact caagaggaaa ggtcccagta tacatatttg aatggttgat     3120

ggttttcaag accttcaggg agctccctgc attttaccta gaaacagaaa aggcccgcaa     3180

aatcttaagt ttcctggcct gcatttcccg ggtaggggca aatgactcca agctggtctc     3240

taagccaata cccttataaa ccagagccca ggaaagacag ctcgagtgta taattctctg     3300

gagctcaatt ctatgcagtt gtgctgatat ttcattaagt cactgtgtat ttttaagtgt     3360

tgatacatta aaagtcgctt tatggaagat gagtaaattt tttaaatact tggaaatttt     3420

atttccttgt taacttctac agatcagggc atgcaaccaa aagcagctta aatgaaatat     3480

tttaaaataa aatatcagga agctattttt agatttcttc tggcttatgt ttctacttta     3540

ggaccctcat tgttctctta ttaaaaaaaa ttatttcctg tgcatctcat ggactgcagg     3600

gtaaattatt tgggcataaa taatttaaat agttttcttt cattttgact atctccagta     3660

ataacagttt ttattatcca gcatattggc ttattgcaca aatcttaaaa tgtacattga     3720

ctactttctg agaagaaagt ggtatcagta ctcatgatga aaaggttact actgaacaaa     3780

ttcacatttc aggaacacct ctatctttgg tttaaatctt actcttagtt tttccgtcta     3840

aaaatcatac tggtattagt atcaggtaag gaaattaaag tttttaaaat ggtttcattc     3900

tctgcaatat gcaaaattta gattttactt tctggtactg taaagaacct gaagtgattt     3960

acacttaatg ggtgattaat ccagtattct ttaccctgaa tgtttggata ttaaagttcc     4020

tttatgtttt ctataacctg tgggatcttc ttgcagtgat tattgtgtgt gagatttttt     4080

ttctttttgg tctatccata ttgttatatt cactcaggta tttttttttt aatcttattc     4140

cagaatcagt ggtttatatt gggttactgt ttaacaccaa atggaattgg cattctgcag     4200

atttaattaa ttatgaaacc agggtctcat tttccttgct gatacttgtt gaaaatgaga     4260

ttcacattct agtctttatt ttcctcctgt tttgtccctg tgcttgtaca tcttcctttt     4320

atttgtgtgt tatagttcta ttccatttga gaaggcagtt ggtaagaact agattgcatg     4380

tacaaagaca ggtttactaa gtgctgtaca gtggtcctga ggttacagtt gaattagaaa     4440

aacgaaatgt acttacagga aataagaaag caaacctttc aaatgagagt gatgatttct     4500

ttaaaaaaaa tcagtttttt tctctcaaat aatgttcttt atttcacgaa atcgtcaatc     4560

ttaagcatga gcagggataa acaactccta gaaggaactc aattcattct tcctggattt     4620

tctctgttgt taaatcacaa aaatgatagt ccccaatcgt ttctttatag gaggttatta     4680

catttcatta cagtcactgc attttgactg ttgtgtttag aatttgaatg tacatccaaa     4740

atgatgagtt tcaatttaag agccttaata aaatgtgtga gtgtgtctca attgaa         4796


<210>  51
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Glu Asp Glu Met Pro Lys Thr Leu Tyr Val Gly Asn Leu Ser Arg 
1               5                   10                  15      


Asp Val Thr Glu Ala Leu Ile Leu Gln Leu Phe Ser Gln Ile Gly Pro 
            20                  25                  30          


Cys Lys Asn Cys Lys Met Ile Met Asp Thr Ala Gly Asn Asp Pro Tyr 
        35                  40                  45              


Cys Phe Val Glu Phe His Glu His Arg His Ala Ala Ala Ala Leu Ala 
    50                  55                  60                  


Ala Met Asn Gly Arg Lys Ile Met Gly Lys Glu Val Lys Val Asn Trp 
65                  70                  75                  80  


Ala Thr Thr Pro Ser Ser Gln Lys Lys Asp Thr Ser Ser Ser Thr Val 
                85                  90                  95      


Val Ser Thr Gln Arg Ser Gln Asp His Phe His Val Phe Val Gly Asp 
            100                 105                 110         


Leu Ser Pro Glu Ile Thr Thr Glu Asp Ile Lys Ala Ala Phe Ala Pro 
        115                 120                 125             


Phe Gly Arg Ile Ser Asp Ala Arg Val Val Lys Asp Met Ala Thr Gly 
    130                 135                 140                 


Lys Ser Lys Gly Tyr Gly Phe Val Ser Phe Phe Asn Lys Trp Asp Ala 
145                 150                 155                 160 


Glu Asn Ala Ile Gln Gln Met Gly Gly Gln Trp Leu Gly Gly Arg Gln 
                165                 170                 175     


Ile Arg Thr Asn Trp Ala Thr Arg Lys Pro Pro Ala Pro Lys Ser Thr 
            180                 185                 190         


Tyr Glu Ser Asn Thr Lys Gln Leu Ser Tyr Asp Glu Val Val Asn Gln 
        195                 200                 205             


Ser Ser Pro Ser Asn Cys Thr Val Tyr Cys Gly Gly Val Thr Ser Gly 
    210                 215                 220                 


Leu Thr Glu Gln Leu Met Arg Gln Thr Phe Ser Pro Phe Gly Gln Ile 
225                 230                 235                 240 


Met Glu Ile Arg Val Phe Pro Asp Lys Gly Tyr Ser Phe Val Arg Phe 
                245                 250                 255     


Asn Ser His Glu Ser Ala Ala His Ala Ile Val Ser Val Asn Gly Thr 
            260                 265                 270         


Thr Ile Glu Gly His Val Val Lys Cys Tyr Trp Gly Lys Glu Thr Leu 
        275                 280                 285             


Asp Met Ile Asn Pro Val Gln Gln Gln Asn Gln Ile Gly Tyr Pro Gln 
    290                 295                 300                 


Pro Tyr Gly Gln Trp Gly Gln Trp Tyr Gly Asn Ala Gln Gln Ile Gly 
305                 310                 315                 320 


Gln Tyr Met Pro Asn Gly Trp Gln Val Pro Ala Tyr Gly Met Tyr Gly 
                325                 330                 335     


Gln Ala Trp Asn Gln Gln Gly Phe Asn Gln Thr Gln Ser Ser Ala Pro 
            340                 345                 350         


Trp Met Gly Pro Asn Tyr Gly Val Gln Pro Pro Gln Gly Gln Asn Gly 
        355                 360                 365             


Ser Met Leu Pro Asn Gln Pro Ser Gly Tyr Arg Val Ala Gly Tyr Glu 
    370                 375                 380                 


Thr Gln 
385     


<210>  52
<211>  1001
<212>  DNA
<213>  Homo sapiens

<400>  52
aatgggggtc agagctgcta tcctttggct agtaaaacaa gattacttgg tgaaattatg       60

taaatctcct cgaaagaaat aagtttcaga gttgtctaga gaatatcact tggactgttc      120

tcaggctttc cactacatct attgtaccac tatggtgccc tgaaaagagg ctttctcagg      180

cttaattcca tggcttagtc tttattccag tatcaaaaag ggggaatccc agccagagct      240

cccatgaggg aggatagctg catgctaacc acattaatct attatcaagg taactcggtc      300

atttttgtca ggcagcacag tgctgtgatt tatagcacat tcatctttgg gagtgggaca      360

agattatcag taaaacctgg taagtaggca atatgtcact aaagtaggag gcttaatgtg      420

gctactgaga cccactaaac ttactgcagt atttggaagg cccaagtgtc aagaaattaa      480

tggtttatgc agacttaagt ggattccaat gaaggaagaa atgttaaagt aatggcacag      540

aggatagaag agctagctgt gaaaaaaaat agccatgtgg atgaaccaaa cgcaacagac      600

tgaaagagcc tagagagttg atcctaaaga aaaaggcaga aagtctggct gagcacttcc      660

agttctgctg acctggcttg attagtgaat ctgggccaca gtatctttat ctataaaatg      720

aaaacattta atatcacctc agattttttg ttttaatttt gtgggtacat aataggtgta      780

tatatttatt ttaaagataa gctaatatat gtgaaagtat tttgtaaatt cttaaatgct      840

atccacatgt aaaatattat ttgtttatag aacaaaaaaa aactatgtca gatttagaat      900

tcttttaaca tgagaatttg taggttctta gtgaaatagc catttacatg tgatctgtag      960

ccctaggcat tggtaaaaag cactttctct tctactgaaa t                         1001


<210>  53
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  53

Ile Tyr Ser Thr Phe Ile Phe Gly Ser Gly Thr Arg Leu Ser Val Lys 
1               5                   10                  15      


Pro 
    


<210>  54
<211>  1001
<212>  DNA
<213>  Homo sapiens

<400>  54
ggtttcaccg ttttagccgg gatggtctcg atctcctgac ctcgtgatcc gcccgcctcg       60

gcctcccaaa gtgctgggat tacaggcgtg agccaccgcg cccggcctca tgatttttaa      120

tagttagatt ttatgcaaaa tttcatttga gggtaaactt aaaggtgaac aagtttaatg      180

gactttggcc atggcagaga aatggttagg tttggatata aggtggacct ctctaattat      240

aagaaaaaaa aggaacatga gaattggtga acaagacctt ccctggagat cttcagaaac      300

ctgaggtcac tcaggagaga aatgtgtgaa gttgagagct tacagtaaat ggtctctgaa      360

gtttcccacc attccaaaga gtgcgtgagc ttaaaatttt tcgtgagttt agctaaatat      420

gtgcttagtg ttagattagg tttcaaccaa gcaaaagaac cctgggagaa gtactctgct      480

tggaaatgaa gcatcctttg gtttttgtgg tacaatagat cactgtgggt tttcagatgg      540

ccagaagctg ctctttgcaa gggggaccat gttaaaggtg gatcttagta agtattatta      600

ctaatgaatt cttaattgat tagtttttga gacaagtaat aagctttttt ggaaatctaa      660

gtggactgcc aaatgttctc gatttatcca tattgcatgg ggagcagagc attcttcatg      720

ccttctccat cctcacttct gccaggtagc agtttgcatt gttaacaggg aagcagaatg      780

gaagcttaac agagaagcag tatggaagac gtctccttag cccagtggtc agttgcatca      840

gagaagtctg ctctgaaatg cgaacacttt ctcttgcagc tggcagcccc ctgcaacctc      900

agtgccctcc atggccaggg ccaaagcttc caggtgccca gataacatcc caaagtcact      960

ctgagagaag agagaaaatc ggtcttactt taccttttct a                         1001


<210>  55
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  55

Phe Ser Asp Gly Gln Lys Leu Leu Phe Ala Arg Gly Thr Met Leu Lys 
1               5                   10                  15      


Val Asp Leu 
            


<210>  56
<211>  1001
<212>  DNA
<213>  Homo sapiens

<400>  56
tgccaaccag agaagctggg ccctttgtag cacaagcctc aggagcagag aatggaggga       60

cattctcaac tgagaggaga gggactagga ggctagatgg gaaatgaggt gactctacag      120

aaaatcgaat atgggatggt ataaaaggat gagaaagatg gcagggggtc cacgatcgct      180

cttgtattta gacctggggg atgcactgat agataccacc tggagagaga aagaggattt      240

ctgtttccct ctgaagaaaa atgtggcaga aaaatcaaaa cagatcgcac atgtcaagcc      300

tctcctaatt acagcctttc attctggttt ctctcagctg ttccagcagg aaatggtagg      360

aaagggtcat tggtgccttt gatgttgtgg aagcattgca ggaaggagat ttgcaagaaa      420

cggggcaggg gcttgcagta gagtctggag agtttagaat gatggttttt gcaatgactt      480

agaacactgt gtatctaact ttggaaatga gaaattaacc tttgggactg gaacaagact      540

caccatcata cccagtaagt tcttcatcct tggtcaggaa atcagcctgc ataagattct      600

ggggatcata gtagagatgc aggcttagag aattttcatc tgtccttgtt cataactggt      660

agagacaggt ggcagccaaa tatctgagtt ttccggggga actccagtcc tgactattta      720

attcaaaact agaaaatatg attcacaatt ctgtttttgc tgctgccgtc aagtgctaat      780

gtggcatgtg aagagaattc aggcagaatg actgcatctt cactttcatc ttgtgtgata      840

attttagctt tgagtactgc aagtgtttgg gagaaatggt agaaacatag aatatcaaag      900

agacaagcaa accaagagac ccagagaggc aggcagacgg aacgtcaggc agtataattt      960

tacaaaacta attcagtgtt gtgtctctct ctgcaaatgg c                         1001


<210>  57
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  57

Ser Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr Arg Leu 
1               5                   10                  15      


Thr Ile Ile Pro 
            20  


<210>  58
<211>  443
<212>  DNA
<213>  Homo sapiens

<400>  58
atgaagccca ccctcatctc agtgcttgtg ataatattta tactcagtaa gtaaagcctc       60

tttttgttct atttttctat ggtattctga tttagaataa ctttaatgaa tattatcccc      120

agtctgtaag acttttcctg atccagaatt ggtgttatag gaggaacaag agcccagaga      180

gtgactcagc ccgagaagct cctctctgtc tttaaagggg ccccagtgga gctgaagtgc      240

aactattcct attctgggag tcctgaactc ttctggtatg tccagtactc cagacaacgc      300

ctccagttac tcttgagaca catctctaga gagagcatca aaggcttcac tgctgacctt      360

aacaaaggcg agacatcttt ccacctgaag aaaccatttg ctcaagagga agactcagcc      420

atgtattact gtgctctaag tgg                                              443


<210>  59
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Lys Pro Thr Leu Ile Ser Val Leu Val Ile Ile Phe Ile Leu Arg 
1               5                   10                  15      


Gly Thr Arg Ala Gln Arg Val Thr Gln Pro Glu Lys Leu Leu Ser Val 
            20                  25                  30          


Phe Lys Gly Ala Pro Val Glu Leu Lys Cys Asn Tyr Ser Tyr Ser Gly 
        35                  40                  45              


Ser Pro Glu Leu Phe Trp Tyr Val Gln Tyr Ser Arg Gln Arg Leu Gln 
    50                  55                  60                  


Leu Leu Leu Arg His Ile Ser Arg Glu Ser Ile Lys Gly Phe Thr Ala 
65                  70                  75                  80  


Asp Leu Asn Lys Gly Glu Thr Ser Phe His Leu Lys Lys Pro Phe Ala 
                85                  90                  95      


Gln Glu Glu Asp Ser Ala Met Tyr Tyr Cys Ala Leu Ser 
            100                 105                 


<210>  60
<211>  460
<212>  DNA
<213>  Homo sapiens

<400>  60
atgggctgca ggctcctctg ctgtgtggtc ttctgcctcc tccaagcagg tgagtcccgg       60

gcccaggtga catgatccta ttggagtccc taagcctttt caccatgaca acaacagcag      120

gccgtctcct aggatttgcc tgaattctgc ttctttcctt tgcaggtccc ttggacacag      180

ctgtttccca gactccaaaa tacctggtca cacagatggg aaacgacaag tccattaaat      240

gtgaacaaaa tctgggccat gatactatgt attggtataa acaggactct aagaaatttc      300

tgaagataat gtttagctac aataataagg agctcattat aaatgaaaca gttccaaatc      360

gcttctcacc taaatctcca gacaaagctc acttaaatct tcacatcaat tccctggagc      420

ttggtgactc tgctgtgtat ttctgtgcca gcagccaaga                            460


<210>  61
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala 
1               5                   10                  15      


Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr 
            20                  25                  30          


Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro 
65                  70                  75                  80  


Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His 
                85                  90                  95      


Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gln 
        


<210>  62
<211>  600
<212>  DNA
<213>  Homo sapiens

<400>  62
atgagctctg aaaattgttt cgtagcagag aacagctctt tgcatccgga gagtggacaa       60

gaaaatgatg ccaccagtcc ccatttctca acacgtcatg aagggtcctt ccaagttcct      120

gtcctgtgtg ctgtaatgaa tgtggtcttc atcaccattt taatcatagc tctcattgcc      180

ttatcagtgg gccaatacaa ttgtccaggc caatacacat tctcaatgcc atcagacagc      240

catgtttctt catgctctga ggactgggtt ggctaccaga ggaaatgcta ctttatttct      300

actgtgaaga ggagctggac ttcagcccaa aatgcttgtt ctgaacatgg tgctactctt      360

gctgtcattg attctgaaaa ggacatgaac tttctaaaac gatacgcagg tagagaggaa      420

cactgggttg gactgaaaaa ggaacctggt cacccatgga agtggtcaaa tggcaaagaa      480

tttaacaact ggttcaacgt tacagggtct gacaagtgtg tttttctgaa aaacacagag      540

gtcagcagca tggaatgtga gaagaattta tactggatat gtaacaaacc ttacaaataa      600


<210>  63
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ser Ser Glu Asn Cys Phe Val Ala Glu Asn Ser Ser Leu His Pro 
1               5                   10                  15      


Glu Ser Gly Gln Glu Asn Asp Ala Thr Ser Pro His Phe Ser Thr Arg 
            20                  25                  30          


His Glu Gly Ser Phe Gln Val Pro Val Leu Cys Ala Val Met Asn Val 
        35                  40                  45              


Val Phe Ile Thr Ile Leu Ile Ile Ala Leu Ile Ala Leu Ser Val Gly 
    50                  55                  60                  


Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Ser Asp Ser 
65                  70                  75                  80  


His Val Ser Ser Cys Ser Glu Asp Trp Val Gly Tyr Gln Arg Lys Cys 
                85                  90                  95      


Tyr Phe Ile Ser Thr Val Lys Arg Ser Trp Thr Ser Ala Gln Asn Ala 
            100                 105                 110         


Cys Ser Glu His Gly Ala Thr Leu Ala Val Ile Asp Ser Glu Lys Asp 
        115                 120                 125             


Met Asn Phe Leu Lys Arg Tyr Ala Gly Arg Glu Glu His Trp Val Gly 
    130                 135                 140                 


Leu Lys Lys Glu Pro Gly His Pro Trp Lys Trp Ser Asn Gly Lys Glu 
145                 150                 155                 160 


Phe Asn Asn Trp Phe Asn Val Thr Gly Ser Asp Lys Cys Val Phe Leu 
                165                 170                 175     


Lys Asn Thr Glu Val Ser Ser Met Glu Cys Glu Lys Asn Leu Tyr Trp 
            180                 185                 190         


Ile Cys Asn Lys Pro Tyr Lys 
        195                 


<210>  64
<211>  1212
<212>  DNA
<213>  Homo sapiens

<400>  64
atgacagcca tcatcaaaga gatcgttagc agaaacaaaa ggagatatca agaggatgga       60

ttcgacttag acttgaccta tatttatcca aacattattg ctatgggatt tcctgcagaa      120

agacttgaag gcgtatacag gaacaatatt gatgatgtag taaggttttt ggattcaaag      180

cataaaaacc attacaagat atacaatctt tgtgctgaaa gacattatga caccgccaaa      240

tttaattgca gagttgcaca atatcctttt gaagaccata acccaccaca gctagaactt      300

atcaaaccct tttgtgaaga tcttgaccaa tggctaagtg aagatgacaa tcatgttgca      360

gcaattcact gtaaagctgg aaagggacga actggtgtaa tgatatgtgc atatttatta      420

catcggggca aatttttaaa ggcacaagag gccctagatt tctatgggga agtaaggacc      480

agagacaaaa agggagtaac tattcccagt cagaggcgct atgtgtatta ttatagctac      540

ctgttaaaga atcatctgga ttatagacca gtggcactgt tgtttcacaa gatgatgttt      600

gaaactattc caatgttcag tggcggaact tgcaatcctc agtttgtggt ctgccagcta      660

aaggtgaaga tatattcctc caattcagga cccacacgac gggaagacaa gttcatgtac      720

tttgagttcc ctcagccgtt acctgtgtgt ggtgatatca aagtagagtt cttccacaaa      780

cagaacaaga tgctaaaaaa ggacaaaatg tttcactttt gggtaaatac attcttcata      840

ccaggaccag aggaaacctc agaaaaagta gaaaatggaa gtctatgtga tcaagaaatc      900

gatagcattt gcagtataga gcgtgcagat aatgacaagg aatatctagt acttacttta      960

acaaaaaatg atcttgacaa agcaaataaa gacaaagcca accgatactt ttctccaaat     1020

tttaaggtga agctgtactt cacaaaaaca gtagaggagc cgtcaaatcc agaggctagc     1080

agttcaactt ctgtaacacc agatgttagt gacaatgaac ctgatcatta tagatattct     1140

gacaccactg actctgatcc agagaatgaa ccttttgatg aagatcagca tacacaaatt     1200

acaaaagtct ga                                                         1212


<210>  65
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


<210>  66
<211>  996
<212>  DNA
<213>  Homo sapiens

<400>  66
atgactgcaa agatggaaac gaccttctat gacgatgccc tcaacgcctc gttcctcccg       60

tccgagagcg gaccttatgg ctacagtaac cccaagatcc tgaaacagag catgaccctg      120

aacctggccg acccagtggg gagcctgaag ccgcacctcc gcgccaagaa ctcggacctc      180

ctcacctcgc ccgacgtggg gctgctcaag ctggcgtcgc ccgagctgga gcgcctgata      240

atccagtcca gcaacgggca catcaccacc acgccgaccc ccacccagtt cctgtgcccc      300

aagaacgtga cagatgagca ggagggcttc gccgagggct tcgtgcgcgc cctggccgaa      360

ctgcacagcc agaacacgct gcccagcgtc acgtcggcgg cgcagccggt caacggggca      420

ggcatggtgg ctcccgcggt agcctcggtg gcagggggca gcggcagcgg cggcttcagc      480

gccagcctgc acagcgagcc gccggtctac gcaaacctca gcaacttcaa cccaggcgcg      540

ctgagcagcg gcggcggggc gccctcctac ggcgcggccg gcctggcctt tcccgcgcaa      600

ccccagcagc agcagcagcc gccgcaccac ctgccccagc agatgcccgt gcagcacccg      660

cggctgcagg ccctgaagga ggagcctcag acagtgcccg agatgcccgg cgagacaccg      720

cccctgtccc ccatcgacat ggagtcccag gagcggatca aggcggagag gaagcgcatg      780

aggaaccgca tcgctgcctc caagtgccga aaaaggaagc tggagagaat cgcccggctg      840

gaggaaaaag tgaaaacctt gaaagctcag aactcggagc tggcgtccac ggccaacatg      900

ctcagggaac aggtggcaca gcttaaacag aaagtcatga accacgttaa cagtgggtgc      960

caactcatgc taacgcagca gttgcaaaca ttttga                                996


<210>  67
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
1               5                   10                  15      


Ser Phe Leu Pro Ser Glu Ser Gly Pro Tyr Gly Tyr Ser Asn Pro Lys 
            20                  25                  30          


Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser 
        35                  40                  45              


Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
    50                  55                  60                  


Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
65                  70                  75                  80  


Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                85                  90                  95      


Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
            100                 105                 110         


Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
        115                 120                 125             


Ser Val Thr Ser Ala Ala Gln Pro Val Asn Gly Ala Gly Met Val Ala 
    130                 135                 140                 


Pro Ala Val Ala Ser Val Ala Gly Gly Ser Gly Ser Gly Gly Phe Ser 
145                 150                 155                 160 


Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                165                 170                 175     


Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
            180                 185                 190         


Ala Gly Leu Ala Phe Pro Ala Gln Pro Gln Gln Gln Gln Gln Pro Pro 
        195                 200                 205             


His His Leu Pro Gln Gln Met Pro Val Gln His Pro Arg Leu Gln Ala 
    210                 215                 220                 


Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly Glu Thr Pro 
225                 230                 235                 240 


Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile Lys Ala Glu 
                245                 250                 255     


Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg 
            260                 265                 270         


Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys 
        275                 280                 285             


Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln 
    290                 295                 300                 


Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn Ser Gly Cys 
305                 310                 315                 320 


Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe 
                325                 330     


