                         SEQUENCE LISTING

<110>  TOTAL RAFFINAGE CHIMIE
       QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY 
       (QIBEBT)
 
<120>  IMPROVED CYTOCHROME P450 FATTY ACID DECARBOXYLASES

<130>  TOTAL-278-PCT

<150>	EP18290089.4
<151>	25-07-2018

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  1278
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized (for expression in E. coli) nucleotide sequence 
       encoding P13G11

<400>  1
atggcaaaaa agctgcctaa agtgaaaggt ctggacaaca ccgtggacat catcaagggt       60

ggctatacct acgtgcctgg caaactggag gagttcgaca gcaaagcatt cgaagtgcgc      120

gccctgggtg gcaagaagat cgcagtgatg agcggcaagg aagccgccga gattttttat      180

gataacgaaa aaatggagcg tcagggtacc ctgccgaagc gcatcgtgaa cacactgttc      240

ggtaaaggcg ccattcatac caccgccggc aagaaacatg tggatcgcaa ggcactgttc      300

atgagcctga tgaccgaggg caatctgaat tacgtgcgcg aactgacgcg tacgctgtgg      360

catgccaata cgcagcgcat ggaaagcatg gacgaggtga acatctaccg cgagtcgatt      420

gtgctgctga ccaaagttgg cacccgctgg gcgggcgttc aggcgccgcc ggaggatatt      480

gaacgcattg cgaccgacat ggacatcatg atcgatagct tccgcgcgtt aggcggcgcg      540

ttcaaaggct acaaagcgtc gaaggaggcg cgtcgccgtg tggaagattg gctggaggag      600

cagatcatcg agacccgcaa aggcaacatt cacccgccgg aaggtaccgc gctgtacgaa      660

ttcgcccatt gggaagacct gaacgataac ccgatggaca gccatctgtg cgccgttgat      720

ctgatgaacg ttgttcgccc gctggcagca attaaccgct tcattagcta cggcgttaaa      780

gtgctgatcg aattcgacca ggaaaaagaa aagctgcgcc tggagaacaa cgaggactac      840

gcctacaagt tcgcacagga agtgcgccgt atctttccgt tcgtgcctta cttaccgggt      900

cgcgccgccg tggatctgga gtatgatggc tataagatcc cggccggtat gatgaccgcc      960

ctggatgttt acggtaccac acacgatgag gatctgtggg agaatccgga tcagttcaac     1020

ccgaatcgtt ttgataactg ggacggcagt ccgtttgatc tgattccgca gggcggtggc     1080

gatttctaca ccaatcatcg ttgcgccggc gagtggatca ccgtgattat tatggaagaa     1140

acaatgaaat actttgccaa caaaattgaa ttcgatgtgc cgagtcagga cctgagcgtt     1200

aaactggaca aactgcctgg caacgtgacc agcggtacca tcattagcaa cgtgcgtccg     1260

cgtgttgccc gcaaataa                                                   1278


<210>  2
<211>  425
<212>  PRT
<213>  Artificial

<220>
<223>  P13G11

<400>  2

Met Ala Lys Lys Leu Pro Lys Val Lys Gly Leu Asp Asn Thr Val Asp 
1               5                   10                  15      


Ile Ile Lys Gly Gly Tyr Thr Tyr Val Pro Gly Lys Leu Glu Glu Phe 
            20                  25                  30          


Asp Ser Lys Ala Phe Glu Val Arg Ala Leu Gly Gly Lys Lys Ile Ala 
        35                  40                  45              


Val Met Ser Gly Lys Glu Ala Ala Glu Ile Phe Tyr Asp Asn Glu Lys 
    50                  55                  60                  


Met Glu Arg Gln Gly Thr Leu Pro Lys Arg Ile Val Asn Thr Leu Phe 
65                  70                  75                  80  


Gly Lys Gly Ala Ile His Thr Thr Ala Gly Lys Lys His Val Asp Arg 
                85                  90                  95      


Lys Ala Leu Phe Met Ser Leu Met Thr Glu Gly Asn Leu Asn Tyr Val 
            100                 105                 110         


Arg Glu Leu Thr Arg Thr Leu Trp His Ala Asn Thr Gln Arg Met Glu 
        115                 120                 125             


Ser Met Asp Glu Val Asn Ile Tyr Arg Glu Ser Ile Val Leu Leu Thr 
    130                 135                 140                 


Lys Val Gly Thr Arg Trp Ala Gly Val Gln Ala Pro Pro Glu Asp Ile 
145                 150                 155                 160 


Glu Arg Ile Ala Thr Asp Met Asp Ile Met Ile Asp Ser Phe Arg Ala 
                165                 170                 175     


Leu Gly Gly Ala Phe Lys Gly Tyr Lys Ala Ser Lys Glu Ala Arg Arg 
            180                 185                 190         


Arg Val Glu Asp Trp Leu Glu Glu Gln Ile Ile Glu Thr Arg Lys Gly 
        195                 200                 205             


Asn Ile His Pro Pro Glu Gly Thr Ala Leu Tyr Glu Phe Ala His Trp 
    210                 215                 220                 


Glu Asp Leu Asn Asp Asn Pro Met Asp Ser His Leu Cys Ala Val Asp 
225                 230                 235                 240 


Leu Met Asn Val Val Arg Pro Leu Ala Ala Ile Asn Arg Phe Ile Ser 
                245                 250                 255     


Tyr Gly Val Lys Val Leu Ile Glu Phe Asp Gln Glu Lys Glu Lys Leu 
            260                 265                 270         


Arg Leu Glu Asn Asn Glu Asp Tyr Ala Tyr Lys Phe Ala Gln Glu Val 
        275                 280                 285             


Arg Arg Ile Phe Pro Phe Val Pro Tyr Leu Pro Gly Arg Ala Ala Val 
    290                 295                 300                 


Asp Leu Glu Tyr Asp Gly Tyr Lys Ile Pro Ala Gly Met Met Thr Ala 
305                 310                 315                 320 


Leu Asp Val Tyr Gly Thr Thr His Asp Glu Asp Leu Trp Glu Asn Pro 
                325                 330                 335     


Asp Gln Phe Asn Pro Asn Arg Phe Asp Asn Trp Asp Gly Ser Pro Phe 
            340                 345                 350         


Asp Leu Ile Pro Gln Gly Gly Gly Asp Phe Tyr Thr Asn His Arg Cys 
        355                 360                 365             


Ala Gly Glu Trp Ile Thr Val Ile Ile Met Glu Glu Thr Met Lys Tyr 
    370                 375                 380                 


Phe Ala Asn Lys Ile Glu Phe Asp Val Pro Ser Gln Asp Leu Ser Val 
385                 390                 395                 400 


Lys Leu Asp Lys Leu Pro Gly Asn Val Thr Ser Gly Thr Ile Ile Ser 
                405                 410                 415     


Asn Val Arg Pro Arg Val Ala Arg Lys 
            420                 425 


<210>  3
<211>  1278
<212>  DNA
<213>  Artificial

<220>
<223>  Codon-optimized (for expression in E. coli) nucleotide sequence 
       encoding P3D3

<400>  3
atggcaaaaa agctgcctaa agtgaaaggt ctggacaaca ccgtggacat catcaagggt       60

ggctatacct acgtgcctgg caaactggag gagttcgaca gcaaagcatt cgaagtgcgc      120

gccctgggtg gcaagaagat cgcagtgatg agcggcaagg aagccgccga gattttttat      180

gataacgaaa aaatggagcg tcagggtacc ctgccgaagc gcatcgtgaa cacactgttc      240

ggtaaaggcg ccattcatac caccgccggc aagaaacatg tggatcgcaa ggcactgttc      300

atgagcctga tgaccgaggg caatctgaat tacgtgcgcg aactgacgcg tacgctgtgg      360

catgccaata cgcagcgcat ggaaagcatg gacgaggtga acatctaccg cgagtcgatt      420

gtgctgctga ccaaagttgg cacccgctgg gcgggcgttc aggcgccgcc ggaggatatt      480

gaacgcattg cgaccgacat ggacatcatg atcgatagct tccgcgcgtt aggcggcgcg      540

ttcaaaggct acaaagcgtc gaaggaggcg cgtcgccgtg tggaagattg gctggaggag      600

cagatcatcg agacccgcaa aggcaacatt cacccgccgg aaggtaccgc gctgtacgaa      660

ttcgcccatt gggaagacta tctgggcaac ccgatggaca gccatctgtg cgccgttgat      720

ctgatgaacg ttgttcgccc gctggcagca attaaccgct tcattagcta cggcgttaaa      780

gtgctgatcg aattcgacca ggaaaaagaa aagctgcgcc tggagaacaa cgaggactac      840

gcctacaagt tcgcacagga agtgcgccgt atctttccgt tcgtgcctta cttaccgggt      900

cgcgccgccg tggatctgga gtatgatggc tataagatcc cggccggtat gatgaccgcc      960

ctggatgttt acggtaccac acacgatgag gatctgtggg agaatccgga tcagttcaac     1020

ccgaatcgtt ttgataactg ggacggcagt ccgtttgatc tgattccgca gggcggtggc     1080

gatttctaca ccaatcatcg ttgcgccggc gagtggatca ccgtgattat tatggaagaa     1140

acaatgaaat actttgccaa caaaattgaa ttcgatgtgc cgagtcagga cctgagcgtt     1200

aaactggaca aactgcctgg caacgtgacc agcggtacca tcattagcaa cgtgcgtccg     1260

cgtgttgccc gcaaataa                                                   1278


<210>  4
<211>  425
<212>  PRT
<213>  Artificial

<220>
<223>  P3D3

<400>  4

Met Ala Lys Lys Leu Pro Lys Val Lys Gly Leu Asp Asn Thr Val Asp 
1               5                   10                  15      


Ile Ile Lys Gly Gly Tyr Thr Tyr Val Pro Gly Lys Leu Glu Glu Phe 
            20                  25                  30          


Asp Ser Lys Ala Phe Glu Val Arg Ala Leu Gly Gly Lys Lys Ile Ala 
        35                  40                  45              


Val Met Ser Gly Lys Glu Ala Ala Glu Ile Phe Tyr Asp Asn Glu Lys 
    50                  55                  60                  


Met Glu Arg Gln Gly Thr Leu Pro Lys Arg Ile Val Asn Thr Leu Phe 
65                  70                  75                  80  


Gly Lys Gly Ala Ile His Thr Thr Ala Gly Lys Lys His Val Asp Arg 
                85                  90                  95      


Lys Ala Leu Phe Met Ser Leu Met Thr Glu Gly Asn Leu Asn Tyr Val 
            100                 105                 110         


Arg Glu Leu Thr Arg Thr Leu Trp His Ala Asn Thr Gln Arg Met Glu 
        115                 120                 125             


Ser Met Asp Glu Val Asn Ile Tyr Arg Glu Ser Ile Val Leu Leu Thr 
    130                 135                 140                 


Lys Val Gly Thr Arg Trp Ala Gly Val Gln Ala Pro Pro Glu Asp Ile 
145                 150                 155                 160 


Glu Arg Ile Ala Thr Asp Met Asp Ile Met Ile Asp Ser Phe Arg Ala 
                165                 170                 175     


Leu Gly Gly Ala Phe Lys Gly Tyr Lys Ala Ser Lys Glu Ala Arg Arg 
            180                 185                 190         


Arg Val Glu Asp Trp Leu Glu Glu Gln Ile Ile Glu Thr Arg Lys Gly 
        195                 200                 205             


Asn Ile His Pro Pro Glu Gly Thr Ala Leu Tyr Glu Phe Ala His Trp 
    210                 215                 220                 


Glu Asp Tyr Leu Gly Asn Pro Met Asp Ser His Leu Cys Ala Val Asp 
225                 230                 235                 240 


Leu Met Asn Val Val Arg Pro Leu Ala Ala Ile Asn Arg Phe Ile Ser 
                245                 250                 255     


Tyr Gly Val Lys Val Leu Ile Glu Phe Asp Gln Glu Lys Glu Lys Leu 
            260                 265                 270         


Arg Leu Glu Asn Asn Glu Asp Tyr Ala Tyr Lys Phe Ala Gln Glu Val 
        275                 280                 285             


Arg Arg Ile Phe Pro Phe Val Pro Tyr Leu Pro Gly Arg Ala Ala Val 
    290                 295                 300                 


Asp Leu Glu Tyr Asp Gly Tyr Lys Ile Pro Ala Gly Met Met Thr Ala 
305                 310                 315                 320 


Leu Asp Val Tyr Gly Thr Thr His Asp Glu Asp Leu Trp Glu Asn Pro 
                325                 330                 335     


Asp Gln Phe Asn Pro Asn Arg Phe Asp Asn Trp Asp Gly Ser Pro Phe 
            340                 345                 350         


Asp Leu Ile Pro Gln Gly Gly Gly Asp Phe Tyr Thr Asn His Arg Cys 
        355                 360                 365             


Ala Gly Glu Trp Ile Thr Val Ile Ile Met Glu Glu Thr Met Lys Tyr 
    370                 375                 380                 


Phe Ala Asn Lys Ile Glu Phe Asp Val Pro Ser Gln Asp Leu Ser Val 
385                 390                 395                 400 


Lys Leu Asp Lys Leu Pro Gly Asn Val Thr Ser Gly Thr Ile Ile Ser 
                405                 410                 415     


Asn Val Arg Pro Arg Val Ala Arg Lys 
            420                 425 


<210>  5
<211>  1275
<212>  DNA
<213>  Artificial

<220>
<223>  codon-optimized nucleotide sequence encoding Sm46-del29

<400>  5
gcaaaaaagc tgcctaaagt gaaaggtctg gacaacaccg tggacatcat caagggtggc       60

tatacctacg tgcctggcaa actggaggag ttcgacagca aagcattcga agtgcgcgcc      120

ctgggtggca agaagatcgc agtgatgagc ggcaaggaag ccgccgagat tttttatgat      180

aacgaaaaaa tggagcgtca gggtaccctg ccgaagcgca tcgtgaacac actgttcggt      240

aaaggcgcca ttcataccac cgccggcaag aaacatgtgg atcgcaaggc actgttcatg      300

agtctgatga ccgatgaaaa tttaaattat ctgcgcgaac tgacacgcaa ctattggttt      360

atgaatacag aacgcatgca gagcatggat aaagtgaatg tgtacaatga aagcatttat      420

atgctgacca aaattggctt ccgctgggcc ggtatcattc agacccctga agaggccgag      480

cagaatgcca aagacatgga caccatgatc aacagctttg tgagcctggg cagcgcctac      540

aagggttaca aaaaagccaa gaaagcccgc aagcgcgtgg aagattttct ggagaaacaa      600

attatcgacg ttcgtaaagg caaactgcat ccggaggaag gtaccgccct gtacgaattc      660

gcccattggg aagacctgaa cgataacccg atggacagcc atctgtgcgc cgttgatctg      720

atgaacgttg ttcgcccgct ggcagcaatt aaccgcttca ttagctacgg cgttaaagtg      780

ctgatcgaat tcgaccagga aaaagaaaag ctgcgcctgg agaacaacga ggactacgcc      840

tacaagttcg cacaggaagt gcgccgtatc tttccgttcg tgccttactt accgggtcgc      900

gccgccgtgg atctggagta tgatggctat aagatcccgg ccggtatgat gaccgccctg      960

gatgtttacg gtaccacaca cgatgaggat ctgtgggaga atccggatca gttcaacccg     1020

aatcgttttg ataactggga cggcagtccg tttgatctga ttccgcaggg cggtggcgat     1080

ttctacacca atcatcgttg cgccggcgag tggatcaccg tgattattat ggaagaaaca     1140

atgaaatact ttgccaacaa aattgaattc gatgtgccga gtcaggacct gagcgttaaa     1200

ctggacaaac tgcctggcaa cgtgaccagc ggtaccatca ttagcaacgt gcgtccgcgt     1260

gttgcccgca aataa                                                      1275


<210>  6
<211>  424
<212>  PRT
<213>  Artificial

<220>
<223>  Sm46-del29

<400>  6

Ala Lys Lys Leu Pro Lys Val Lys Gly Leu Asp Asn Thr Val Asp Ile 
1               5                   10                  15      


Ile Lys Gly Gly Tyr Thr Tyr Val Pro Gly Lys Leu Glu Glu Phe Asp 
            20                  25                  30          


Ser Lys Ala Phe Glu Val Arg Ala Leu Gly Gly Lys Lys Ile Ala Val 
        35                  40                  45              


Met Ser Gly Lys Glu Ala Ala Glu Ile Phe Tyr Asp Asn Glu Lys Met 
    50                  55                  60                  


Glu Arg Gln Gly Thr Leu Pro Lys Arg Ile Val Asn Thr Leu Phe Gly 
65                  70                  75                  80  


Lys Gly Ala Ile His Thr Thr Ala Gly Lys Lys His Val Asp Arg Lys 
                85                  90                  95      


Ala Leu Phe Met Ser Leu Met Thr Asp Glu Asn Leu Asn Tyr Leu Arg 
            100                 105                 110         


Glu Leu Thr Arg Asn Tyr Trp Phe Met Asn Thr Glu Arg Met Gln Ser 
        115                 120                 125             


Met Asp Lys Val Asn Val Tyr Asn Glu Ser Ile Tyr Met Leu Thr Lys 
    130                 135                 140                 


Ile Gly Phe Arg Trp Ala Gly Ile Ile Gln Thr Pro Glu Glu Ala Glu 
145                 150                 155                 160 


Gln Asn Ala Lys Asp Met Asp Thr Met Ile Asn Ser Phe Val Ser Leu 
                165                 170                 175     


Gly Ser Ala Tyr Lys Gly Tyr Lys Lys Ala Lys Lys Ala Arg Lys Arg 
            180                 185                 190         


Val Glu Asp Phe Leu Glu Lys Gln Ile Ile Asp Val Arg Lys Gly Lys 
        195                 200                 205             


Leu His Pro Glu Glu Gly Thr Ala Leu Tyr Glu Phe Ala His Trp Glu 
    210                 215                 220                 


Asp Leu Asn Asp Asn Pro Met Asp Ser His Leu Cys Ala Val Asp Leu 
225                 230                 235                 240 


Met Asn Val Val Arg Pro Leu Ala Ala Ile Asn Arg Phe Ile Ser Tyr 
                245                 250                 255     


Gly Val Lys Val Leu Ile Glu Phe Asp Gln Glu Lys Glu Lys Leu Arg 
            260                 265                 270         


Leu Glu Asn Asn Glu Asp Tyr Ala Tyr Lys Phe Ala Gln Glu Val Arg 
        275                 280                 285             


Arg Ile Phe Pro Phe Val Pro Tyr Leu Pro Gly Arg Ala Ala Val Asp 
    290                 295                 300                 


Leu Glu Tyr Asp Gly Tyr Lys Ile Pro Ala Gly Met Met Thr Ala Leu 
305                 310                 315                 320 


Asp Val Tyr Gly Thr Thr His Asp Glu Asp Leu Trp Glu Asn Pro Asp 
                325                 330                 335     


Gln Phe Asn Pro Asn Arg Phe Asp Asn Trp Asp Gly Ser Pro Phe Asp 
            340                 345                 350         


Leu Ile Pro Gln Gly Gly Gly Asp Phe Tyr Thr Asn His Arg Cys Ala 
        355                 360                 365             


Gly Glu Trp Ile Thr Val Ile Ile Met Glu Glu Thr Met Lys Tyr Phe 
    370                 375                 380                 


Ala Asn Lys Ile Glu Phe Asp Val Pro Ser Gln Asp Leu Ser Val Lys 
385                 390                 395                 400 


Leu Asp Lys Leu Pro Gly Asn Val Thr Ser Gly Thr Ile Ile Ser Asn 
                405                 410                 415     


Val Arg Pro Arg Val Ala Arg Lys 
            420                 


<210>  7
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Enzyme fragment 1

<400>  7

Thr Leu Trp His Ala Asn Thr Gln Arg Met Glu Ser Met Asp Glu Val 
1               5                   10                  15      


Asn Ile Tyr Arg Glu Ser Ile Val Leu 
            20                  25  


<210>  8
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Enzyme fragment 2

<400>  8

Thr Leu Trp His Ala Asn Thr Gln Arg Met Glu Ser Met Asp Glu Val 
1               5                   10                  15      


Asn Ile Tyr Arg Glu Ser Ile Val Leu Leu Thr Lys Val Gly Thr Arg 
            20                  25                  30          


Trp Ala Gly Val Gln Ala Pro Pro Glu Asp Ile Glu Arg Ile Ala Thr 
        35                  40                  45              


Asp Met Asp Ile Met Ile Asp Ser Phe Arg Ala Leu Gly Gly Ala Phe 
    50                  55                  60                  


Lys Gly Tyr Lys Ala Ser Lys Glu Ala Arg Arg Arg Val Glu Asp Trp 
65                  70                  75                  80  


Leu Glu Glu Gln Ile Ile Glu Thr Arg Lys Gly Asn Ile His Pro Pro 
                85                  90                  95      


<210>  9
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Enzyme fragment 3

<400>  9

Thr Leu Trp His Ala Asn Thr Gln Arg Met Glu Ser Met Asp Glu Val 
1               5                   10                  15      


Asn Ile Tyr Arg Glu Ser Ile Val Leu Leu Thr Lys Val Gly Thr Arg 
            20                  25                  30          


Trp Ala Gly Val Gln Ala Pro Pro Glu Asp Ile Glu Arg Ile Ala Thr 
        35                  40                  45              


Asp Met Asp Ile Met Ile Asp Ser Phe Arg Ala Leu Gly Gly Ala Phe 
    50                  55                  60                  


Lys Gly Tyr Lys Ala Ser Lys Glu Ala Arg Arg Arg Val Glu Asp Trp 
65                  70                  75                  80  


Leu Glu Glu Gln Ile Ile Glu Thr Arg Lys Gly Asn Ile His Pro Pro 
                85                  90                  95      


Glu Gly Thr Ala Leu Tyr Glu Phe Ala His Trp Glu Asp Tyr Leu Gly 
            100                 105                 110         


<210>  10
<211>  425
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of P26H9

<400>  10

Met Ala Lys Lys Leu Pro Lys Val Lys Gly Leu Asp Asn Thr Val Asp 
1               5                   10                  15      


Ile Ile Lys Gly Gly Tyr Thr Tyr Val Pro Gly Lys Leu Glu Glu Phe 
            20                  25                  30          


Asp Ser Lys Ala Phe Glu Val Arg Ala Leu Gly Gly Lys Lys Ile Ala 
        35                  40                  45              


Val Met Ser Gly Lys Glu Ala Ala Glu Ile Phe Tyr Asp Asn Glu Lys 
    50                  55                  60                  


Met Glu Arg Gln Gly Thr Leu Pro Lys Arg Ile Val Asn Thr Leu Phe 
65                  70                  75                  80  


Gly Lys Gly Ala Ile His Thr Thr Ala Gly Lys Lys His Val Asp Arg 
                85                  90                  95      


Lys Ala Leu Phe Met Ser Leu Met Thr Asp Glu Asn Leu Asn Tyr Leu 
            100                 105                 110         


Arg Glu Leu Thr Arg Asn Tyr Trp Phe Met Asn Thr Glu Arg Met Gln 
        115                 120                 125             


Ser Met Asp Lys Val Asn Val His Asn Glu Ser Ile Tyr Met Leu Thr 
    130                 135                 140                 


Lys Ile Gly Phe Arg Trp Ala Gly Ile Ile Gln Thr Pro Glu Glu Ala 
145                 150                 155                 160 


Glu Gln Asn Ala Lys Asp Met Asp Thr Met Ile Asn Ser Phe Val Ser 
                165                 170                 175     


Leu Gly Ser Ala Tyr Lys Gly Tyr Lys Lys Ala Lys Lys Ala Arg Lys 
            180                 185                 190         


Arg Val Glu Asp Phe Leu Glu Lys Gln Ile Ile Asp Val Arg Lys Gly 
        195                 200                 205             


Lys Leu His Pro Glu Glu Gly Thr Ala Leu Tyr Glu Phe Ala His Trp 
    210                 215                 220                 


Glu Asp Leu Asn Asp Asn Pro Met Asp Ser His Leu Cys Ala Val Asp 
225                 230                 235                 240 


Leu Met Asn Val Val Arg Pro Leu Ala Ala Ile Asn Arg Phe Ile Ser 
                245                 250                 255     


Tyr Gly Val Lys Val Leu Ile Glu Phe Asp Gln Glu Lys Glu Lys Leu 
            260                 265                 270         


Arg Leu Glu Asn Asn Glu Asp Tyr Ala Tyr Lys Phe Ala Gln Glu Val 
        275                 280                 285             


Arg Arg Ile Phe Pro Phe Val Pro Tyr Leu Pro Gly Arg Ala Ala Val 
    290                 295                 300                 


Asp Leu Glu Tyr Asp Gly Tyr Lys Ile Pro Ala Gly Met Met Thr Ala 
305                 310                 315                 320 


Leu Asp Val Tyr Gly Thr Thr His Asp Glu Asp Leu Trp Glu Asn Pro 
                325                 330                 335     


Asp Gln Phe Asn Pro Asn Arg Phe Asp Asn Trp Asp Gly Ser Pro Phe 
            340                 345                 350         


Asp Leu Ile Pro Gln Gly Gly Gly Asp Phe Tyr Thr Asn His Arg Cys 
        355                 360                 365             


Ala Gly Glu Trp Ile Thr Val Ile Ile Met Glu Glu Thr Met Lys Tyr 
    370                 375                 380                 


Phe Ala Asn Lys Ile Glu Phe Asp Val Pro Ser Gln Asp Leu Ser Val 
385                 390                 395                 400 


Lys Leu Asp Lys Leu Pro Gly Asn Val Thr Ser Gly Thr Ile Ile Ser 
                405                 410                 415     


Asn Val Arg Pro Arg Val Ala Arg Lys 
            420                 425 


<210>  11
<211>  425
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of P40E6

<400>  11

Met Ala Lys Lys Leu Pro Lys Val Lys Gly Leu Asp Asn Thr Val Asp 
1               5                   10                  15      


Ile Ile Lys Gly Gly Tyr Thr Tyr Val Pro Gly Lys Leu Lys Glu Phe 
            20                  25                  30          


Asp Ser Lys Ala Phe Glu Val Arg Ala Leu Gly Gly Lys Lys Ile Ala 
        35                  40                  45              


Val Met Ser Gly Lys Glu Ala Ala Glu Ile Phe Tyr Asp Asn Glu Lys 
    50                  55                  60                  


Met Glu Arg Gln Gly Thr Leu Pro Lys Arg Ile Val Asn Thr Leu Phe 
65                  70                  75                  80  


Gly Lys Gly Ala Ile His Thr Thr Ala Gly Lys Lys His Val Asp Arg 
                85                  90                  95      


Lys Ala Leu Phe Met Ser Leu Met Thr Asp Glu Asn Leu Asn Tyr Leu 
            100                 105                 110         


Arg Glu Leu Thr Arg Asn Tyr Trp Phe Met Asn Thr Glu Arg Met Gln 
        115                 120                 125             


Ser Met Asp Lys Val Asn Val Tyr Asn Glu Ser Ile Tyr Met Leu Thr 
    130                 135                 140                 


Lys Ile Gly Phe Arg Trp Ala Gly Ile Ile Gln Thr Pro Glu Glu Ala 
145                 150                 155                 160 


Glu Gln Asn Ala Lys Asp Met Asp Thr Met Ile Asn Ser Phe Val Ser 
                165                 170                 175     


Leu Gly Ser Ala Tyr Lys Gly Tyr Lys Lys Ala Lys Lys Ala Arg Lys 
            180                 185                 190         


Arg Val Glu Asp Phe Leu Glu Lys Gln Ile Ile Asp Val Arg Lys Gly 
        195                 200                 205             


Lys Leu His Pro Glu Glu Gly Thr Ala Leu Tyr Glu Phe Ala His Trp 
    210                 215                 220                 


Glu Asp Leu Asn Asp Asn Pro Met Asp Ser His Leu Cys Ala Val Asp 
225                 230                 235                 240 


Leu Met Asn Val Val Arg Pro Leu Ala Ala Ile Asn Arg Phe Ile Ser 
                245                 250                 255     


Tyr Gly Val Lys Val Leu Ile Glu Phe Asp Gln Glu Lys Glu Lys Leu 
            260                 265                 270         


Arg Leu Glu Asn Asn Glu Asp Tyr Ala Tyr Lys Phe Ala Gln Glu Val 
        275                 280                 285             


Arg Arg Ile Phe Pro Phe Val Pro Tyr Leu Pro Gly Arg Ala Ala Val 
    290                 295                 300                 


Asp Leu Glu Tyr Asp Gly Tyr Lys Ile Pro Ala Gly Met Met Thr Ala 
305                 310                 315                 320 


Leu Asp Val Tyr Gly Thr Thr His Asp Glu Asp Leu Trp Glu Asn Pro 
                325                 330                 335     


Asp Gln Phe Asn Pro Asn Arg Phe Asp Asn Trp Asp Gly Ser Pro Phe 
            340                 345                 350         


Asp Leu Ile Pro Gln Gly Gly Gly Asp Phe Tyr Thr Asn His Arg Cys 
        355                 360                 365             


Ala Gly Glu Trp Ile Thr Val Ile Ile Met Glu Glu Thr Met Lys Tyr 
    370                 375                 380                 


Phe Ala Asn Lys Ile Glu Phe Asp Val Pro Ser Gln Asp Leu Ser Val 
385                 390                 395                 400 


Lys Leu Asp Lys Leu Pro Gly Asn Val Thr Ser Gly Thr Ile Ile Ser 
                405                 410                 415     


Asn Val Arg Pro Arg Val Ala Arg Lys 
            420                 425 


<210>  12
<211>  425
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of P42E11

<400>  12

Met Ala Lys Lys Leu Pro Lys Val Lys Gly Leu Asp Asn Thr Val Asp 
1               5                   10                  15      


Ile Ile Lys Gly Gly Tyr Thr Tyr Val Pro Gly Lys Leu Glu Glu Phe 
            20                  25                  30          


Asp Ser Lys Ala Phe Glu Val Arg Ala Leu Gly Gly Lys Lys Ile Ala 
        35                  40                  45              


Val Met Ser Gly Lys Glu Ala Ala Glu Ile Phe Tyr Asp Asn Glu Lys 
    50                  55                  60                  


Met Glu Arg Gln Gly Thr Leu Pro Lys Arg Ile Val Asn Thr Leu Phe 
65                  70                  75                  80  


Gly Lys Gly Ala Ile His Thr Thr Ala Gly Lys Lys His Val Asp Arg 
                85                  90                  95      


Lys Ala Leu Phe Met Ser Leu Met Thr Asp Glu Asn Leu Asn Tyr Leu 
            100                 105                 110         


Arg Glu Leu Thr Arg Asn Tyr Trp Phe Met Asn Thr Glu Arg Met Gln 
        115                 120                 125             


Ser Met Asp Lys Val Asn Val Tyr Asn Glu Ser Ile Tyr Met Leu Thr 
    130                 135                 140                 


Lys Ile Gly Phe Arg Trp Ala Gly Ile Ile Gln Thr Pro Glu Glu Ala 
145                 150                 155                 160 


Glu Gln Asn Ala Lys Asp Met Asp Thr Met Ile Asn Ser Phe Val Ser 
                165                 170                 175     


Leu Gly Ser Ala Tyr Lys Gly Tyr Lys Lys Ala Lys Lys Ala Arg Lys 
            180                 185                 190         


Arg Val Glu Asp Phe Leu Glu Lys Gln Ile Ile Asp Val Arg Lys Gly 
        195                 200                 205             


Lys Leu His Pro Glu Glu Gly Thr Ala Leu Tyr Glu Phe Ala His Trp 
    210                 215                 220                 


Glu Asp Leu Asn Asp Asn Pro Met Asp Ser His Leu Cys Ala Val Asp 
225                 230                 235                 240 


Leu Ile Asn Val Val Arg Pro Leu Ala Ala Ile Asn Arg Phe Ile Ser 
                245                 250                 255     


Tyr Gly Val Lys Val Leu Ile Glu Phe Asp Gln Glu Lys Glu Lys Leu 
            260                 265                 270         


Arg Leu Glu Asn Asn Glu Asp Tyr Ala Tyr Lys Phe Ala Gln Glu Val 
        275                 280                 285             


Arg Arg Ile Phe Pro Phe Val Pro Tyr Leu Pro Gly Arg Ala Ala Val 
    290                 295                 300                 


Asp Leu Glu Tyr Asp Gly Tyr Lys Ile Pro Ala Gly Met Met Thr Ala 
305                 310                 315                 320 


Leu Asp Val Tyr Gly Thr Thr His Asp Glu Asp Leu Trp Glu Asn Pro 
                325                 330                 335     


Asp Gln Phe Asn Pro Asn Arg Phe Asp Asn Trp Asp Gly Ser Pro Phe 
            340                 345                 350         


Asp Leu Ile Pro Gln Gly Gly Gly Asp Phe Tyr Thr Asn His Arg Cys 
        355                 360                 365             


Ala Gly Glu Trp Ile Thr Val Ile Ile Met Glu Glu Thr Met Lys Tyr 
    370                 375                 380                 


Phe Ala Asn Lys Ile Glu Phe Asp Val Pro Ser Gln Asp Leu Ser Val 
385                 390                 395                 400 


Lys Pro Asp Lys Leu Pro Gly Asn Val Thr Ser Gly Thr Ile Ile Ser 
                405                 410                 415     


Asn Val Arg Pro Arg Val Ala Arg Lys 
            420                 425 


<210>  13
<211>  425
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of P21G12

<400>  13

Met Ala Lys Lys Leu Pro Lys Val Lys Gly Leu Asp Asn Thr Val Asp 
1               5                   10                  15      


Ile Ile Lys Gly Gly Tyr Thr Tyr Val Pro Gly Lys Leu Glu Glu Phe 
            20                  25                  30          


Asp Ser Lys Ala Phe Glu Val Arg Ala Leu Gly Gly Lys Lys Ile Ala 
        35                  40                  45              


Val Met Ser Gly Lys Glu Ala Ala Glu Ile Phe Tyr Asp Asn Glu Lys 
    50                  55                  60                  


Met Glu Arg Gln Gly Thr Leu Pro Lys Arg Ile Val Asn Thr Leu Phe 
65                  70                  75                  80  


Gly Lys Gly Ala Ile His Thr Thr Ala Gly Lys Lys His Val Asp Arg 
                85                  90                  95      


Lys Ala Leu Phe Met Ser Leu Met Thr Asp Glu Asn Leu Asn Tyr Leu 
            100                 105                 110         


Arg Glu Leu Thr Arg Asn Tyr Trp Phe Met Asn Thr Glu Arg Met Gln 
        115                 120                 125             


Ser Met Asp Lys Val Asn Val Tyr Asn Glu Ser Ile Tyr Met Leu Thr 
    130                 135                 140                 


Lys Ile Gly Phe Arg Trp Ala Gly Ile Ile Gln Thr Pro Glu Glu Ala 
145                 150                 155                 160 


Glu Gln Asn Ala Lys Asp Met Asp Thr Met Ile Asn Ser Phe Val Ser 
                165                 170                 175     


Leu Gly Ser Ala Tyr Lys Gly Tyr Lys Lys Ala Lys Lys Ala Arg Lys 
            180                 185                 190         


Arg Val Glu Asp Phe Leu Glu Lys Gln Ile Ile Asp Val Arg Lys Gly 
        195                 200                 205             


Lys Leu His Pro Glu Glu Gly Thr Ala Leu Tyr Glu Phe Ala His Trp 
    210                 215                 220                 


Glu Asp Tyr Leu Gly Asn Pro Met Asp Ser His Leu Cys Ala Val Asp 
225                 230                 235                 240 


Leu Met Asn Val Val Arg Pro Leu Ala Ala Ile Asn Arg Phe Ile Ser 
                245                 250                 255     


Tyr Gly Val Lys Val Leu Ile Glu Phe Asp Gln Glu Lys Glu Lys Leu 
            260                 265                 270         


Arg Leu Glu Asn Asn Glu Asp Tyr Ala Tyr Lys Phe Ala Gln Glu Val 
        275                 280                 285             


Arg Arg Ile Phe Pro Phe Val Pro Tyr Leu Pro Gly Arg Ala Ala Val 
    290                 295                 300                 


Asp Leu Glu Tyr Asp Gly Tyr Lys Ile Pro Ala Gly Met Met Thr Ala 
305                 310                 315                 320 


Leu Asp Val Tyr Gly Thr Thr His Asp Glu Asp Leu Trp Glu Asn Pro 
                325                 330                 335     


Asp Gln Phe Asn Pro Asn Arg Phe Asp Asn Trp Asp Gly Ser Pro Phe 
            340                 345                 350         


Asp Leu Ile Pro Gln Gly Gly Gly Asp Phe Tyr Thr Asn His Arg Cys 
        355                 360                 365             


Ala Gly Glu Trp Ile Thr Val Ile Ile Met Glu Glu Thr Met Lys Tyr 
    370                 375                 380                 


Phe Ala Asn Lys Ile Glu Phe Asp Val Pro Ser Gln Asp Leu Ser Val 
385                 390                 395                 400 


Lys Leu Asp Lys Leu Pro Gly Asn Val Thr Ser Gly Thr Ile Ile Ser 
                405                 410                 415     


Asn Val Arg Pro Arg Val Ala Arg Lys 
            420                 425 


<210>  14
<211>  425
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of P41A3

<400>  14

Met Ala Lys Lys Leu Pro Lys Val Lys Gly Leu Asp Asn Thr Val Asp 
1               5                   10                  15      


Ile Ile Lys Gly Gly Tyr Thr Tyr Val Pro Gly Lys Leu Glu Glu Phe 
            20                  25                  30          


Asp Ser Lys Ala Phe Glu Val Arg Ala Leu Gly Gly Lys Lys Ile Ala 
        35                  40                  45              


Val Met Ser Gly Lys Glu Ala Ala Glu Ile Phe Tyr Asp Asn Glu Lys 
    50                  55                  60                  


Met Glu Arg Gln Gly Thr Leu Pro Lys Arg Ile Val Asn Thr Leu Phe 
65                  70                  75                  80  


Gly Lys Gly Ala Ile His Thr Thr Ala Gly Lys Lys His Val Asp Arg 
                85                  90                  95      


Lys Ala Leu Phe Met Ser Leu Met Thr Asp Glu Asn Leu Asn Tyr Leu 
            100                 105                 110         


Arg Glu Leu Thr Arg Asn Tyr Trp Phe Met Asn Thr Glu Arg Met Gln 
        115                 120                 125             


Ser Met Asp Lys Val Asn Val Tyr Asn Glu Ser Ile Tyr Met Leu Thr 
    130                 135                 140                 


Lys Ile Gly Phe Arg Trp Ala Gly Ile Ile Gln Thr Pro Glu Glu Ala 
145                 150                 155                 160 


Glu Gln Asn Ala Lys Asp Met Asp Thr Met Ile Asn Ser Phe Val Ser 
                165                 170                 175     


Leu Gly Ser Ala Tyr Lys Gly Tyr Lys Lys Ala Lys Lys Ala Arg Lys 
            180                 185                 190         


Arg Val Glu Asp Phe Leu Glu Lys Gln Ile Ile Asp Val Arg Lys Gly 
        195                 200                 205             


Lys Leu His Pro Glu Glu Gly Thr Ala Leu Tyr Glu Phe Ala His Trp 
    210                 215                 220                 


Glu Asp Leu Asn Asp Asn Pro Met Asp Ser His Leu Cys Ala Val Asp 
225                 230                 235                 240 


Leu Met Asn Val Val Arg Pro Leu Ala Ala Ile Asn Arg Phe Ile Ser 
                245                 250                 255     


Tyr Gly Val Lys Val Leu Ile Glu Phe Asp Gln Glu Lys Glu Lys Leu 
            260                 265                 270         


Arg Leu Glu Asn Asn Glu Asp Tyr Ala Tyr Lys Phe Ala Gln Glu Val 
        275                 280                 285             


Arg Arg Ile Phe Pro Phe Val Pro Tyr Leu Pro Gly Arg Ala Ala Val 
    290                 295                 300                 


Asp Leu Glu Tyr Asp Gly Tyr Lys Ile Pro Ala Gly Met Met Thr Ala 
305                 310                 315                 320 


Leu Asp Val Tyr Gly Thr Thr His Asp Glu Ser Leu Trp Asp Asp Pro 
                325                 330                 335     


Asn Glu Phe Arg Pro Glu Arg Phe Glu Thr Trp Asp Gly Ser Pro Phe 
            340                 345                 350         


Asp Leu Ile Pro Gln Gly Gly Gly Asp Phe Tyr Thr Asn His Arg Cys 
        355                 360                 365             


Ala Gly Glu Trp Ile Thr Val Ile Ile Met Glu Glu Thr Met Lys Tyr 
    370                 375                 380                 


Phe Ala Glu Lys Ile Lys Tyr Asp Val Pro Glu Gln Asp Leu Glu Val 
385                 390                 395                 400 


Asp Leu Asn Ser Ile Pro Gly Tyr Val Lys Ser Gly Phe Val Ile Lys 
                405                 410                 415     


Asn Val Arg Glu Val Val Asp Arg Thr 
            420                 425 


