                         SEQUENCE LISTING

<110>  BIOGAIA AB
 
<120>  THERAPEUTIC METHODS USING BACTERIAL STRAINS WHICH ARE CAPABLE OF INCREASING ADENOSINE LEVELS

<130>  69.141539/02

<150>  GB 1905591.2
<151>  2019-04-18

<150>  GB 1905470.9
<151>  2019-04-17

<150>  GB 1812079.0
<151>  2018-07-24

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Motif


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  any amino acid

<400>  1

Leu Pro Xaa Thr Gly 
1               5   


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer LrNuc1f

<400>  2
ggaactttgg gaaaccatga                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer LrNuc1r

<400>  3
cgggcaactt taccatcact                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer LrNuc2f

<400>  4
tactcgtgaa aatgccgttg                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer LrNuc2r

<400>  5
gtgcccctgt catttcaact                                                   20


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer LrNuc3f

<400>  6
agctttacca aattgaccct ga                                                22


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer LrNuc3r

<400>  7
ttgatattag gcgcatcctt tt                                                22


<210>  8
<211>  2259
<212>  DNA
<213>  Lactobacillus reuteri SD112

<400>  8
atgaagaata atagttcaaa atattgttta ttgttaggga cagcgctgtt aggactatat       60

ttccaagcta atagtgttca tgcggatgcg actggtatca cagctaatgg agaaactacc      120

catagcaatg ttactccaat ggttcagact aataaggatg aggcaagtac accgcaaaca      180

actactgatt ggtctgaccc ggccaaatat caaagtgaca ttccagttca gattttagga      240

atcaatgact tgcatggtgg gttagaaacg actggatcag ctacgattgg agataagact      300

tattcgaatg ccggaacagt tgcacgccta gctggtaacc ttgatgcggc ggaggaaagt      360

tttaagaacg ctaatccgac gggaagctca attcgggtag aagccggaga tatggttggg      420

gcttctccag caaattctgc tcttctccaa gacgaatcaa ccatgcatgc tttagacgca      480

atgcattttg aaataggaac tttgggaaac catgagttcg atgaaggttt agctgagtat      540

atgcggattg ttaatggtgg tgaacctact aaacaatata atgaagctga gatggcctat      600

cctcatgtga aaacagggat taatatcatt actgccaatg ttgtaaataa atctgatggt      660

caaatcccat ttggaatgca accatacttg attaaagaaa ttcatactag tgatggtaaa      720

gttgcccgga tcggatttat tgggattgaa actacttccc taccaatttt aaccttatac      780

gataattaca aagattatga tgttttagac gaggctgaaa caattgcaaa atatgatcaa      840

attttacgca aaaaaggtgt taacgcaatt gtagttcttg cccatacagg ggtttcaact      900

gataaagatg gcagcactaa aggtaatgct gttgatatca ttaagaagct ttaccaaatt      960

gaccctgata attctgtcga cctttatatt gctggtcact cccaccaata tgctaatgct     1020

actgttggaa gtgtaaaatt agtgcaagcc atttacacgg gtaaagctta cgatgatatt     1080

atcggttaca tcgatccaac aactaatgat tttgcgccca atagtctcgt ttcacatgtc     1140

tttccggtac tatctgaaaa ggatgcgcct aatatcaaaa cggatgcaaa tgttacagca     1200

attgttgaag atgcgaacaa ccgagtagca ccgattatta acaagaaaat aggggaagct     1260

gctacaacag gcgatattct tggacgactt cataatactc ctactcgtga aaatgccgtt     1320

ggtgaattag ttgtcgatgg tcaattatat gccgctcata aagtaggctt accagctgat     1380

tttgcgatga ctaatacagg gggcgttcgt gcagatctgc atgttaatcc tgatcgttcc     1440

attacatggg ggagtgccca agcagttcaa ccatttggta atattttgcg ggtagttgaa     1500

atgacagggg cacaaatcgt tgaagccttg aatcaacaat acgacgaaga tcaagcttac     1560

tacttacaga tttccgggct acattatact tatactgacc aaaacgatcc taaccaacca     1620

tataaggtcg ttcaagttta tgaccaacat aatcaaccgc ttgatatgaa taagacttac     1680

aatgttgtta ttaatgactt tttagcaggt ggcggagatg gcttttctgc atttaagggt     1740

actaaagttg tcgggattgt tggtcaagat acagacgcgt ttattgacta tattactgat     1800

atgactaatg atggtaaacc aattactgcg ccaacaatga accgtaagat ttacttgact     1860

gctgaacaag tagcgaaggc tgactcagat tcacagttac aaacaggaac taatcagaac     1920

actcaaaacg atgctaattc ccagactgaa ggaaatcagc ttcaagaagt tccgagccaa     1980

ccggtatctc caacagtaac cttgccaaca acagctggtc aacccgccga aactgttaca     2040

ctacatgctc aatctaagca acaaaccgta gctgctaata atcaattaat taatttgacg     2100

cctacatcaa ttaatggcca aaaacaaaaa gcagctgacc agcaagcagc tttaccacaa     2160

actagtaacg atgaagatct tgcattactt cttctcggaa gttcattaat ggcagcaacc     2220

ggattgacaa ttattgatcg caagcgtaaa catgcttaa                            2259


<210>  9
<211>  752
<212>  PRT
<213>  Lactobacillus reuteri SD112

<400>  9

Met Lys Asn Asn Ser Ser Lys Tyr Cys Leu Leu Leu Gly Thr Ala Leu 
1               5                   10                  15      


Leu Gly Leu Tyr Phe Gln Ala Asn Ser Val His Ala Asp Ala Thr Gly 
            20                  25                  30          


Ile Thr Ala Asn Gly Glu Thr Thr His Ser Asn Val Thr Pro Met Val 
        35                  40                  45              


Gln Thr Asn Lys Asp Glu Ala Ser Thr Pro Gln Thr Thr Thr Asp Trp 
    50                  55                  60                  


Ser Asp Pro Ala Lys Tyr Gln Ser Asp Ile Pro Val Gln Ile Leu Gly 
65                  70                  75                  80  


Ile Asn Asp Leu His Gly Gly Leu Glu Thr Thr Gly Ser Ala Thr Ile 
                85                  90                  95      


Gly Asp Lys Thr Tyr Ser Asn Ala Gly Thr Val Ala Arg Leu Ala Gly 
            100                 105                 110         


Asn Leu Asp Ala Ala Glu Glu Ser Phe Lys Asn Ala Asn Pro Thr Gly 
        115                 120                 125             


Ser Ser Ile Arg Val Glu Ala Gly Asp Met Val Gly Ala Ser Pro Ala 
    130                 135                 140                 


Asn Ser Ala Leu Leu Gln Asp Glu Ser Thr Met His Ala Leu Asp Ala 
145                 150                 155                 160 


Met His Phe Glu Ile Gly Thr Leu Gly Asn His Glu Phe Asp Glu Gly 
                165                 170                 175     


Leu Ala Glu Tyr Met Arg Ile Val Asn Gly Gly Glu Pro Thr Lys Gln 
            180                 185                 190         


Tyr Asn Glu Ala Glu Met Ala Tyr Pro His Val Lys Thr Gly Ile Asn 
        195                 200                 205             


Ile Ile Thr Ala Asn Val Val Asn Lys Ser Asp Gly Gln Ile Pro Phe 
    210                 215                 220                 


Gly Met Gln Pro Tyr Leu Ile Lys Glu Ile His Thr Ser Asp Gly Lys 
225                 230                 235                 240 


Val Ala Arg Ile Gly Phe Ile Gly Ile Glu Thr Thr Ser Leu Pro Ile 
                245                 250                 255     


Leu Thr Leu Tyr Asp Asn Tyr Lys Asp Tyr Asp Val Leu Asp Glu Ala 
            260                 265                 270         


Glu Thr Ile Ala Lys Tyr Asp Gln Ile Leu Arg Lys Lys Gly Val Asn 
        275                 280                 285             


Ala Ile Val Val Leu Ala His Thr Gly Val Ser Thr Asp Lys Asp Gly 
    290                 295                 300                 


Ser Thr Lys Gly Asn Ala Val Asp Ile Ile Lys Lys Leu Tyr Gln Ile 
305                 310                 315                 320 


Asp Pro Asp Asn Ser Val Asp Leu Tyr Ile Ala Gly His Ser His Gln 
                325                 330                 335     


Tyr Ala Asn Ala Thr Val Gly Ser Val Lys Leu Val Gln Ala Ile Tyr 
            340                 345                 350         


Thr Gly Lys Ala Tyr Asp Asp Ile Ile Gly Tyr Ile Asp Pro Thr Thr 
        355                 360                 365             


Asn Asp Phe Ala Pro Asn Ser Leu Val Ser His Val Phe Pro Val Leu 
    370                 375                 380                 


Ser Glu Lys Asp Ala Pro Asn Ile Lys Thr Asp Ala Asn Val Thr Ala 
385                 390                 395                 400 


Ile Val Glu Asp Ala Asn Asn Arg Val Ala Pro Ile Ile Asn Lys Lys 
                405                 410                 415     


Ile Gly Glu Ala Ala Thr Thr Gly Asp Ile Leu Gly Arg Leu His Asn 
            420                 425                 430         


Thr Pro Thr Arg Glu Asn Ala Val Gly Glu Leu Val Val Asp Gly Gln 
        435                 440                 445             


Leu Tyr Ala Ala His Lys Val Gly Leu Pro Ala Asp Phe Ala Met Thr 
    450                 455                 460                 


Asn Thr Gly Gly Val Arg Ala Asp Leu His Val Asn Pro Asp Arg Ser 
465                 470                 475                 480 


Ile Thr Trp Gly Ser Ala Gln Ala Val Gln Pro Phe Gly Asn Ile Leu 
                485                 490                 495     


Arg Val Val Glu Met Thr Gly Ala Gln Ile Val Glu Ala Leu Asn Gln 
            500                 505                 510         


Gln Tyr Asp Glu Asp Gln Ala Tyr Tyr Leu Gln Ile Ser Gly Leu His 
        515                 520                 525             


Tyr Thr Tyr Thr Asp Gln Asn Asp Pro Asn Gln Pro Tyr Lys Val Val 
    530                 535                 540                 


Gln Val Tyr Asp Gln His Asn Gln Pro Leu Asp Met Asn Lys Thr Tyr 
545                 550                 555                 560 


Asn Val Val Ile Asn Asp Phe Leu Ala Gly Gly Gly Asp Gly Phe Ser 
                565                 570                 575     


Ala Phe Lys Gly Thr Lys Val Val Gly Ile Val Gly Gln Asp Thr Asp 
            580                 585                 590         


Ala Phe Ile Asp Tyr Ile Thr Asp Met Thr Asn Asp Gly Lys Pro Ile 
        595                 600                 605             


Thr Ala Pro Thr Met Asn Arg Lys Ile Tyr Leu Thr Ala Glu Gln Val 
    610                 615                 620                 


Ala Lys Ala Asp Ser Asp Ser Gln Leu Gln Thr Gly Thr Asn Gln Asn 
625                 630                 635                 640 


Thr Gln Asn Asp Ala Asn Ser Gln Thr Glu Gly Asn Gln Leu Gln Glu 
                645                 650                 655     


Val Pro Ser Gln Pro Val Ser Pro Thr Val Thr Leu Pro Thr Thr Ala 
            660                 665                 670         


Gly Gln Pro Ala Glu Thr Val Thr Leu His Ala Gln Ser Lys Gln Gln 
        675                 680                 685             


Thr Val Ala Ala Asn Asn Gln Leu Ile Asn Leu Thr Pro Thr Ser Ile 
    690                 695                 700                 


Asn Gly Gln Lys Gln Lys Ala Ala Asp Gln Gln Ala Ala Leu Pro Gln 
705                 710                 715                 720 


Thr Ser Asn Asp Glu Asp Leu Ala Leu Leu Leu Leu Gly Ser Ser Leu 
                725                 730                 735     


Met Ala Ala Thr Gly Leu Thr Ile Ile Asp Arg Lys Arg Lys His Ala 
            740                 745                 750         


