
                                SEQUENCE LISTING

<110> Fred Hutchinson Cancer Research Center
      Srivastava, Shivani
      Salter, Alexander
      Riddell, Stanley R.

<120> COMPOSITIONS AND METHODS FOR CONTROLLED 
      EXPRESSION OF ANTIGEN-SPECIFIC RECEPTORS

<130> 360056.467WO

<140> PCT
<141> 2019-07-19

<150> US 62/797,161
<151> 2019-01-25

<150> US 62/701,355
<151> 2018-07-20

<160> 113

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 940
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - HUMAN ROR1

<400> 1
Arg Ala Arg Gly Cys Ser Ala Arg Arg Arg Gly Thr Arg Pro Pro Leu
 1               5                  10                  15
Leu Ala Leu Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala
            20                  25                  30
Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser
        35                  40                  45
Trp Asn Ile Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp
    50                  55                  60
Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu
65                  70                  75                  80
His Cys Lys Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys
                85                  90                  95
Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser
            100                 105                 110
Thr Ile Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp
        115                 120                 125
Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser
    130                 135                 140
Ser Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser
145                 150                 155                 160
Pro Gly Tyr Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr
                165                 170                 175
Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met
            180                 185                 190
Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala
        195                 200                 205
Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln
    210                 215                 220
Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu
225                 230                 235                 240
Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu
                245                 250                 255
Ile Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser
            260                 265                 270
Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu
        275                 280                 285
Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile
    290                 295                 300
Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr
305                 310                 315                 320
Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln
                325                 330                 335
Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala
            340                 345                 350
Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro
        355                 360                 365
Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe
    370                 375                 380
Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys
385                 390                 395                 400
Glu Lys Asn Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala
                405                 410                 415
Ile Pro Leu Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg
            420                 425                 430
Asn Asn Gln Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His
        435                 440                 445
Val Arg Gly Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro
    450                 455                 460
Lys Ser Lys Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu
465                 470                 475                 480
Glu Leu Gly Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr
                485                 490                 495
Leu Pro Gly Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys
            500                 505                 510
Asp Tyr Asn Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser
        515                 520                 525
Leu Met Ala Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala
    530                 535                 540
Val Thr Gln Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln
545                 550                 555                 560
Gly Asp Leu His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val
                565                 570                 575
Gly Cys Ser Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His
            580                 585                 590
Gly Asp Phe Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr
        595                 600                 605
Leu Ser Ser His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile
    610                 615                 620
Leu Ile Gly Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser
625                 630                 635                 640
Arg Glu Ile Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu
                645                 650                 655
Leu Pro Ile Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe
            660                 665                 670
Ser Ser Asp Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile
        675                 680                 685
Phe Ser Phe Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val
    690                 695                 700
Ile Glu Met Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys
705                 710                 715                 720
Pro Pro Arg Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro
                725                 730                 735
Ser Arg Arg Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp
            740                 745                 750
Glu Gly Leu Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn
        755                 760                 765
Ala Thr Thr Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu
    770                 775                 780
Ser Asn Pro Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr
785                 790                 795                 800
Pro Gln Gly Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn
                805                 810                 815
Gln Arg Phe Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala
            820                 825                 830
Ala Phe Pro Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile
        835                 840                 845
Gln His Cys Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly
    850                 855                 860
Ser Thr Ser Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn
865                 870                 875                 880
Gln Glu Ala Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His
                885                 890                 895
Pro Gly Gly Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro
            900                 905                 910
Tyr Lys Ile Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile
        915                 920                 925
His Gly His Thr Glu Ser Met Ile Ser Ala Glu Leu
    930                 935                 940

<210> 2
<211> 533
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HUMAN B7-H3 (CD276) PRECURSOR

<400> 2
Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala
 1               5                  10                  15
Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln
            20                  25                  30
Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu
        35                  40                  45
Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn
    50                  55                  60
Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala
65                  70                  75                  80
Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe
                85                  90                  95
Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val
            100                 105                 110
Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp
        115                 120                 125
Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys
    130                 135                 140
Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr
145                 150                 155                 160
Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val
                165                 170                 175
Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr
            180                 185                 190
Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu
        195                 200                 205
Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn
    210                 215                 220
Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln
225                 230                 235                 240
Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val
                245                 250                 255
Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro
            260                 265                 270
Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr
        275                 280                 285
Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly
    290                 295                 300
Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln
305                 310                 315                 320
Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly
                325                 330                 335
Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val
            340                 345                 350
Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu
        355                 360                 365
Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser
    370                 375                 380
Ser Tyr Arg Gly Tyr Pro Ala Glu Val Phe Trp Gln Asp Gly Gln Gly
385                 390                 395                 400
Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln
                405                 410                 415
Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala Asn
            420                 425                 430
Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala
        435                 440                 445
His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro Glu
    450                 455                 460
Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu Leu
465                 470                 475                 480
Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys Glu
                485                 490                 495
Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly Ser
            500                 505                 510
Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp Asp
        515                 520                 525
Gly Gln Glu Ile Ala
    530

<210> 3
<211> 314
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HUMAN EPCAM PRECURSOR

<400> 3
Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala
 1               5                  10                  15
Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr
            20                  25                  30
Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys
        35                  40                  45
Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala
    50                  55                  60
Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg
65                  70                  75                  80
Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp
                85                  90                  95
Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly
            100                 105                 110
Thr Ser Met Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp
        115                 120                 125
Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile
    130                 135                 140
Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys
145                 150                 155                 160
Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu
                165                 170                 175
Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr
            180                 185                 190
Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp
        195                 200                 205
Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser
    210                 215                 220
Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu
225                 230                 235                 240
Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala
                245                 250                 255
Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile
            260                 265                 270
Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile
        275                 280                 285
Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu
    290                 295                 300
Met Gly Glu Met His Arg Glu Leu Asn Ala
305                 310

<210> 4
<211> 385
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence NOTCH CORE DOMAIN-CONTAINING
      POLYPEPTIDE (MURINE NOTCH1

<400> 4
Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro Pro
 1               5                  10                  15
Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp Ala
            20                  25                  30
Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly Trp
        35                  40                  45
Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys
    50                  55                  60
Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp
65                  70                  75                  80
Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln
                85                  90                  95
Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp
            100                 105                 110
His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys
        115                 120                 125
Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala
    130                 135                 140
Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu Arg
145                 150                 155                 160
Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His Thr
                165                 170                 175
Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe Pro
            180                 185                 190
Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ser
        195                 200                 205
Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly Gly
    210                 215                 220
Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile Val
225                 230                 235                 240
Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln Cys
                245                 250                 255
Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser
            260                 265                 270
Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu
        275                 280                 285
Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val Ala
    290                 295                 300
Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu
305                 310                 315                 320
Ser Arg Lys Arg Arg Arg Met Lys Leu Leu Ser Ser Ile Glu Gln Ala
                325                 330                 335
Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro
            340                 345                 350
Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro
        355                 360                 365
Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu
    370                 375                 380
Ser
385

<210> 5
<211> 2555
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HUMAN NOTCH1, PRECURSOR

<400> 5
Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala
 1               5                  10                  15
Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu
            20                  25                  30
Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys
        35                  40                  45
Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu
    50                  55                  60
Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg
65                  70                  75                  80
Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro
                85                  90                  95
Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg
            100                 105                 110
Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg
        115                 120                 125
Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys
    130                 135                 140
Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala
145                 150                 155                 160
Ser Tyr Ile Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg
                165                 170                 175
Gln Asp Val Asn Glu Cys Gly Gln Lys Pro Gly Leu Cys Arg His Gly
            180                 185                 190
Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala
        195                 200                 205
Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro
    210                 215                 220
Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr
225                 230                 235                 240
His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu
                245                 250                 255
Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys
            260                 265                 270
Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr
        275                 280                 285
Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn
    290                 295                 300
Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn
305                 310                 315                 320
Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile
                325                 330                 335
Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp
            340                 345                 350
Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu
        355                 360                 365
Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly
    370                 375                 380
Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys
385                 390                 395                 400
Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys
                405                 410                 415
Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr
            420                 425                 430
Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg
        435                 440                 445
Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp
    450                 455                 460
Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro
465                 470                 475                 480
Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser
                485                 490                 495
Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe
            500                 505                 510
Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp
        515                 520                 525
Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu
    530                 535                 540
Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly
545                 550                 555                 560
Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His
                565                 570                 575
Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg
            580                 585                 590
Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser
        595                 600                 605
Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala
    610                 615                 620
Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile
625                 630                 635                 640
Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu
                645                 650                 655
Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly
            660                 665                 670
Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His
        675                 680                 685
Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys
    690                 695                 700
Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys
705                 710                 715                 720
Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly
                725                 730                 735
Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile
            740                 745                 750
Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys
        755                 760                 765
Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser
    770                 775                 780
Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys
785                 790                 795                 800
Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn
                805                 810                 815
Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro
            820                 825                 830
Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu
        835                 840                 845
Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln
    850                 855                 860
Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His
865                 870                 875                 880
Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln
                885                 890                 895
Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg
            900                 905                 910
Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr
        915                 920                 925
Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu
    930                 935                 940
Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys
945                 950                 955                 960
Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser
                965                 970                 975
Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys
            980                 985                 990
Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser Phe Thr Cys Leu
        995                 1000                1005
Cys Pro Pro Gly Phe Thr Gly Ser Tyr Cys Gln His Asp Val Asn Glu
    1010                1015                1020
Cys Asp Ser Gln Pro Cys Leu His Gly Gly Thr Cys Gln Asp Gly Cys
1025                1030                1035                1040
Gly Ser Tyr Arg Cys Thr Cys Pro Gln Gly Tyr Thr Gly Pro Asn Cys
                1045                1050                1055
Gln Asn Leu Val His Trp Cys Asp Ser Ser Pro Cys Lys Asn Gly Gly
            1060                1065                1070
Lys Cys Trp Gln Thr His Thr Gln Tyr Arg Cys Glu Cys Pro Ser Gly
        1075                1080                1085
Trp Thr Gly Leu Tyr Cys Asp Val Pro Ser Val Ser Cys Glu Val Ala
    1090                1095                1100
Ala Gln Arg Gln Gly Val Asp Val Ala Arg Leu Cys Gln His Gly Gly
1105                1110                1115                1120
Leu Cys Val Asp Ala Gly Asn Thr His His Cys Arg Cys Gln Ala Gly
                1125                1130                1135
Tyr Thr Gly Ser Tyr Cys Glu Asp Leu Val Asp Glu Cys Ser Pro Ser
            1140                1145                1150
Pro Cys Gln Asn Gly Ala Thr Cys Thr Asp Tyr Leu Gly Gly Tyr Ser
        1155                1160                1165
Cys Lys Cys Val Ala Gly Tyr His Gly Val Asn Cys Ser Glu Glu Ile
    1170                1175                1180
Asp Glu Cys Leu Ser His Pro Cys Gln Asn Gly Gly Thr Cys Leu Asp
1185                1190                1195                1200
Leu Pro Asn Thr Tyr Lys Cys Ser Cys Pro Arg Gly Thr Gln Gly Val
                1205                1210                1215
His Cys Glu Ile Asn Val Asp Asp Cys Asn Pro Pro Val Asp Pro Val
            1220                1225                1230
Ser Arg Ser Pro Lys Cys Phe Asn Asn Gly Thr Cys Val Asp Gln Val
        1235                1240                1245
Gly Gly Tyr Ser Cys Thr Cys Pro Pro Gly Phe Val Gly Glu Arg Cys
    1250                1255                1260
Glu Gly Asp Val Asn Glu Cys Leu Ser Asn Pro Cys Asp Ala Arg Gly
1265                1270                1275                1280
Thr Gln Asn Cys Val Gln Arg Val Asn Asp Phe His Cys Glu Cys Arg
                1285                1290                1295
Ala Gly His Thr Gly Arg Arg Cys Glu Ser Val Ile Asn Gly Cys Lys
            1300                1305                1310
Gly Lys Pro Cys Lys Asn Gly Gly Thr Cys Ala Val Ala Ser Asn Thr
        1315                1320                1325
Ala Arg Gly Phe Ile Cys Lys Cys Pro Ala Gly Phe Glu Gly Ala Thr
    1330                1335                1340
Cys Glu Asn Asp Ala Arg Thr Cys Gly Ser Leu Arg Cys Leu Asn Gly
1345                1350                1355                1360
Gly Thr Cys Ile Ser Gly Pro Arg Ser Pro Thr Cys Leu Cys Leu Gly
                1365                1370                1375
Pro Phe Thr Gly Pro Glu Cys Gln Phe Pro Ala Ser Ser Pro Cys Leu
            1380                1385                1390
Gly Gly Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro Thr Ser Glu
        1395                1400                1405
Ser Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn Gly Leu Leu
    1410                1415                1420
Cys His Ile Leu Asp Tyr Ser Phe Gly Gly Gly Ala Gly Arg Asp Ile
1425                1430                1435                1440
Pro Pro Pro Leu Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Glu
                1445                1450                1455
Asp Ala Gly Asn Lys Val Cys Ser Leu Gln Cys Asn Asn His Ala Cys
            1460                1465                1470
Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys
        1475                1480                1485
Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His
    1490                1495                1500
Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp
1505                1510                1515                1520
Cys Gln Arg Ala Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys
                1525                1530                1535
Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala
            1540                1545                1550
Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg
        1555                1560                1565
Leu Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln
    1570                1575                1580
Leu Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu
1585                1590                1595                1600
His Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile
                1605                1610                1615
Phe Pro Tyr Tyr Gly Arg Glu Glu Glu Leu Arg Lys His Pro Ile Lys
            1620                1625                1630
Arg Ala Ala Glu Gly Trp Ala Ala Pro Asp Ala Leu Leu Gly Gln Val
        1635                1640                1645
Lys Ala Ser Leu Leu Pro Gly Gly Ser Glu Gly Gly Arg Arg Arg Arg
    1650                1655                1660
Glu Leu Asp Pro Met Asp Val Arg Gly Ser Ile Val Tyr Leu Glu Ile
1665                1670                1675                1680
Asp Asn Arg Gln Cys Val Gln Ala Ser Ser Gln Cys Phe Gln Ser Ala
                1685                1690                1695
Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu
            1700                1705                1710
Asn Ile Pro Tyr Lys Ile Glu Ala Val Gln Ser Glu Thr Val Glu Pro
        1715                1720                1725
Pro Pro Pro Ala Gln Leu His Phe Met Tyr Val Ala Ala Ala Ala Phe
    1730                1735                1740
Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg
1745                1750                1755                1760
Arg Arg Gln His Gly Gln Leu Trp Phe Pro Glu Gly Phe Lys Val Ser
                1765                1770                1775
Glu Ala Ser Lys Lys Lys Arg Arg Glu Pro Leu Gly Glu Asp Ser Val
            1780                1785                1790
Gly Leu Lys Pro Leu Lys Asn Ala Ser Asp Gly Ala Leu Met Asp Asp
        1795                1800                1805
Asn Gln Asn Glu Trp Gly Asp Glu Asp Leu Glu Thr Lys Lys Phe Arg
    1810                1815                1820
Phe Glu Glu Pro Val Val Leu Pro Asp Leu Asp Asp Gln Thr Asp His
1825                1830                1835                1840
Arg Gln Trp Thr Gln Gln His Leu Asp Ala Ala Asp Leu Arg Met Ser
                1845                1850                1855
Ala Met Ala Pro Thr Pro Pro Gln Gly Glu Val Asp Ala Asp Cys Met
            1860                1865                1870
Asp Val Asn Val Arg Gly Pro Asp Gly Phe Thr Pro Leu Met Ile Ala
        1875                1880                1885
Ser Cys Ser Gly Gly Gly Leu Glu Thr Gly Asn Ser Glu Glu Glu Glu
    1890                1895                1900
Asp Ala Pro Ala Val Ile Ser Asp Phe Ile Tyr Gln Gly Ala Ser Leu
1905                1910                1915                1920
His Asn Gln Thr Asp Arg Thr Gly Glu Thr Ala Leu His Leu Ala Ala
                1925                1930                1935
Arg Tyr Ser Arg Ser Asp Ala Ala Lys Arg Leu Leu Glu Ala Ser Ala
            1940                1945                1950
Asp Ala Asn Ile Gln Asp Asn Met Gly Arg Thr Pro Leu His Ala Ala
        1955                1960                1965
Val Ser Ala Asp Ala Gln Gly Val Phe Gln Ile Leu Ile Arg Asn Arg
    1970                1975                1980
Ala Thr Asp Leu Asp Ala Arg Met His Asp Gly Thr Thr Pro Leu Ile
1985                1990                1995                2000
Leu Ala Ala Arg Leu Ala Val Glu Gly Met Leu Glu Asp Leu Ile Asn
                2005                2010                2015
Ser His Ala Asp Val Asn Ala Val Asp Asp Leu Gly Lys Ser Ala Leu
            2020                2025                2030
His Trp Ala Ala Ala Val Asn Asn Val Asp Ala Ala Val Val Leu Leu
        2035                2040                2045
Lys Asn Gly Ala Asn Lys Asp Met Gln Asn Asn Arg Glu Glu Thr Pro
    2050                2055                2060
Leu Phe Leu Ala Ala Arg Glu Gly Ser Tyr Glu Thr Ala Lys Val Leu
2065                2070                2075                2080
Leu Asp His Phe Ala Asn Arg Asp Ile Thr Asp His Met Asp Arg Leu
                2085                2090                2095
Pro Arg Asp Ile Ala Gln Glu Arg Met His His Asp Ile Val Arg Leu
            2100                2105                2110
Leu Asp Glu Tyr Asn Leu Val Arg Ser Pro Gln Leu His Gly Ala Pro
        2115                2120                2125
Leu Gly Gly Thr Pro Thr Leu Ser Pro Pro Leu Cys Ser Pro Asn Gly
    2130                2135                2140
Tyr Leu Gly Ser Leu Lys Pro Gly Val Gln Gly Lys Lys Val Arg Lys
2145                2150                2155                2160
Pro Ser Ser Lys Gly Leu Ala Cys Gly Ser Lys Glu Ala Lys Asp Leu
                2165                2170                2175
Lys Ala Arg Arg Lys Lys Ser Gln Asp Gly Lys Gly Cys Leu Leu Asp
            2180                2185                2190
Ser Ser Gly Met Leu Ser Pro Val Asp Ser Leu Glu Ser Pro His Gly
        2195                2200                2205
Tyr Leu Ser Asp Val Ala Ser Pro Pro Leu Leu Pro Ser Pro Phe Gln
    2210                2215                2220
Gln Ser Pro Ser Val Pro Leu Asn His Leu Pro Gly Met Pro Asp Thr
2225                2230                2235                2240
His Leu Gly Ile Gly His Leu Asn Val Ala Ala Lys Pro Glu Met Ala
                2245                2250                2255
Ala Leu Gly Gly Gly Gly Arg Leu Ala Phe Glu Thr Gly Pro Pro Arg
            2260                2265                2270
Leu Ser His Leu Pro Val Ala Ser Gly Thr Ser Thr Val Leu Gly Ser
        2275                2280                2285
Ser Ser Gly Gly Ala Leu Asn Phe Thr Val Gly Gly Ser Thr Ser Leu
    2290                2295                2300
Asn Gly Gln Cys Glu Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro
2305                2310                2315                2320
Asn Gln Tyr Asn Pro Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser
                2325                2330                2335
Thr Gln Ala Pro Ser Leu Gln His Gly Met Val Gly Pro Leu His Ser
            2340                2345                2350
Ser Leu Ala Ala Ser Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu
        2355                2360                2365
Pro Ser Thr Arg Leu Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln
    2370                2375                2380
Val Gln Pro Gln Asn Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala
2385                2390                2395                2400
Asn Ile Gln Gln Gln Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro Gln
                2405                2410                2415
Pro His Leu Gly Val Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser
            2420                2425                2430
Phe Leu Ser Gly Glu Pro Ser Gln Ala Asp Val Gln Pro Leu Gly Pro
        2435                2440                2445
Ser Ser Leu Ala Val His Thr Ile Leu Pro Gln Glu Ser Pro Ala Leu
    2450                2455                2460
Pro Thr Ser Leu Pro Ser Ser Leu Val Pro Pro Val Thr Ala Ala Gln
2465                2470                2475                2480
Phe Leu Thr Pro Pro Ser Gln His Ser Tyr Ser Ser Pro Val Asp Asn
                2485                2490                2495
Thr Pro Ser His Gln Leu Gln Val Pro Glu His Pro Phe Leu Thr Pro
            2500                2505                2510
Ser Pro Glu Ser Pro Asp Gln Trp Ser Ser Ser Ser Pro His Ser Asn
        2515                2520                2525
Val Ser Asp Trp Ser Glu Gly Val Ser Ser Pro Pro Thr Ser Met Gln
    2530                2535                2540
Ser Gln Ile Ala Arg Ile Pro Glu Ala Phe Lys
2545                2550                2555

<210> 6
<211> 152
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence GAL4-VP64 POLYPEPTIDE

<400> 6
Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu
 1               5                  10                  15
Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala
            20                  25                  30
Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val
        35                  40                  45
Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg
    50                  55                  60
Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys
65                  70                  75                  80
Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly
                85                  90                  95
Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly
            100                 105                 110
Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala
        115                 120                 125
Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp
    130                 135                 140
Phe Asp Leu Asp Met Leu Gly Ser
145                 150

<210> 7
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ANTI-B7-H3 SCFV (VH-LINKER-VL)

<400> 7
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
 1               5                  10                  15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30
Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45
Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe
    50                  55                  60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Arg Gly Ile Pro Arg Leu Trp Tyr Phe Asp Val Trp Gly Ala
            100                 105                 110
Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys
        115                 120                 125
Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Gln Met Thr Gln
    130                 135                 140
Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser
145                 150                 155                 160
Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln
                165                 170                 175
Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu
            180                 185                 190
His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
        195                 200                 205
Tyr Ser Leu Thr Ile Asp Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr
    210                 215                 220
Phe Cys Gln Gln Gly Asn Thr Leu Pro Pro Thr Phe Gly Gly Gly Thr
225                 230                 235                 240
Lys Leu Glu Ile Lys
                245

<210> 8
<211> 243
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ANTI-EPCAM SCFV

<400> 8
Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe
            20                  25                  30
Pro Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Thr Ile Ser Thr Ser Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95
Thr Arg Thr Leu Tyr Ile Leu Arg Val Phe Tyr Phe Asp Tyr Trp Gly
            100                 105                 110
Gln Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro
    130                 135                 140
Ala Ser Leu Ser Ala Ser Leu Gly Glu Thr Val Ser Ile Glu Cys Leu
145                 150                 155                 160
Ala Ser Glu Gly Ile Ser Asn Asp Leu Ala Trp Tyr Gln Gln Lys Ser
                165                 170                 175
Gly Lys Ser Pro Gln Leu Leu Ile Tyr Ala Thr Ser Arg Leu Gln Asp
            180                 185                 190
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Tyr Ser
        195                 200                 205
Leu Lys Ile Ser Gly Met Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys
    210                 215                 220
Gln Gln Ser Tyr Lys Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
225                 230                 235                 240
Glu Leu Lys


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence MYC TAG

<400> 9
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu
 1               5                  10

<210> 10
<211> 792
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ANTI-B7-H3 TRIGGER POLYPEPTIDE

<400> 10
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln Val Gln Leu Gln Gln
 1               5                  10                  15
Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Leu Ser Cys
            20                  25                  30
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met Gln Trp Val Lys
        35                  40                  45
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Thr Ile Tyr Pro Gly
    50                  55                  60
Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe Lys Gly Lys Ala Thr Leu
65                  70                  75                  80
Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu
                85                  90                  95
Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ile Pro
            100                 105                 110
Arg Leu Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val
        115                 120                 125
Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly
    130                 135                 140
Ser Thr Lys Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser
145                 150                 155                 160
Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp
                165                 170                 175
Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val
            180                 185                 190
Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser
        195                 200                 205
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Asp
    210                 215                 220
Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn
225                 230                 235                 240
Thr Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ile
                245                 250                 255
Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro Pro Pro
            260                 265                 270
Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp Ala Gly
        275                 280                 285
Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp
    290                 295                 300
Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys Thr
305                 310                 315                 320
Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp Ser
                325                 330                 335
Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln Leu
            340                 345                 350
Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp His
        355                 360                 365
Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys Glu
    370                 375                 380
Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala Ala
385                 390                 395                 400
Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu Arg Asn
                405                 410                 415
Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His Thr Asn
            420                 425                 430
Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe Pro Tyr
        435                 440                 445
Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ser Thr
    450                 455                 460
Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly Gly Arg
465                 470                 475                 480
Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile Val Tyr
                485                 490                 495
Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln Cys Phe
            500                 505                 510
Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu
        515                 520                 525
Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu Pro
    530                 535                 540
Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val Ala Ala
545                 550                 555                 560
Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser
                565                 570                 575
Arg Lys Arg Arg Arg Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys
            580                 585                 590
Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys
        595                 600                 605
Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys
    610                 615                 620
Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser
625                 630                 635                 640
Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu
                645                 650                 655
Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala
            660                 665                 670
Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val
        675                 680                 685
Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg
    690                 695                 700
Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys
705                 710                 715                 720
Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly
                725                 730                 735
Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly
            740                 745                 750
Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala
        755                 760                 765
Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp
    770                 775                 780
Phe Asp Leu Asp Met Leu Gly Ser
785                 790

<210> 11
<211> 817
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ANTI-EpCAM TRIGGER POLYPEPTIDE
      with signal peptide (murine)

<400> 11
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu
 1               5                  10                  15
Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Glu Gln Lys Leu Ile
            20                  25                  30
Ser Glu Glu Asp Leu Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Leu
        35                  40                  45
Val Gln Pro Gly Arg Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe
    50                  55                  60
Thr Phe Ser Asn Phe Pro Met Ala Trp Val Arg Gln Ala Pro Thr Lys
65                  70                  75                  80
Gly Leu Glu Trp Val Ala Thr Ile Ser Thr Ser Gly Gly Ser Thr Tyr
                85                  90                  95
Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
            100                 105                 110
Lys Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr
        115                 120                 125
Ala Thr Tyr Tyr Cys Thr Arg Thr Leu Tyr Ile Leu Arg Val Phe Tyr
    130                 135                 140
Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser Gly Gly
145                 150                 155                 160
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln
                165                 170                 175
Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly Glu Thr Val
            180                 185                 190
Ser Ile Glu Cys Leu Ala Ser Glu Gly Ile Ser Asn Asp Leu Ala Trp
        195                 200                 205
Tyr Gln Gln Lys Ser Gly Lys Ser Pro Gln Leu Leu Ile Tyr Ala Thr
    210                 215                 220
Ser Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser
225                 230                 235                 240
Gly Thr Arg Tyr Ser Leu Lys Ile Ser Gly Met Gln Pro Glu Asp Glu
                245                 250                 255
Ala Asp Tyr Phe Cys Gln Gln Ser Tyr Lys Tyr Pro Trp Thr Phe Gly
            260                 265                 270
Gly Gly Thr Lys Leu Glu Leu Lys Ile Leu Asp Tyr Ser Phe Thr Gly
        275                 280                 285
Gly Ala Gly Arg Asp Ile Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu
    290                 295                 300
Leu Pro Glu Cys Gln Val Asp Ala Gly Asn Lys Val Cys Asn Leu Gln
305                 310                 315                 320
Cys Asn Asn His Ala Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn
                325                 330                 335
Phe Asn Asp Pro Trp Lys Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys
            340                 345                 350
Tyr Phe Ser Asp Gly His Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys
        355                 360                 365
Leu Phe Asp Gly Phe Asp Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro
    370                 375                 380
Leu Tyr Asp Gln Tyr Cys Lys Asp His Phe Ser Asp Gly His Cys Asp
385                 390                 395                 400
Gln Gly Cys Asn Ser Ala Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala
                405                 410                 415
Glu His Val Pro Glu Arg Leu Ala Ala Gly Thr Leu Val Leu Val Val
            420                 425                 430
Leu Leu Pro Pro Asp Gln Leu Arg Asn Asn Ser Phe His Phe Leu Arg
        435                 440                 445
Glu Leu Ser His Val Leu His Thr Asn Val Val Phe Lys Arg Asp Ala
    450                 455                 460
Gln Gly Gln Gln Met Ile Phe Pro Tyr Tyr Gly His Glu Glu Glu Leu
465                 470                 475                 480
Arg Lys His Pro Ile Lys Arg Ser Thr Val Gly Trp Ala Thr Ser Ser
                485                 490                 495
Leu Leu Pro Gly Thr Ser Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro
            500                 505                 510
Met Asp Ile Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln
        515                 520                 525
Cys Val Gln Ser Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala
    530                 535                 540
Ala Phe Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr
545                 550                 555                 560
Lys Ile Glu Ala Val Lys Ser Glu Pro Val Glu Pro Pro Leu Pro Ser
                565                 570                 575
Gln Leu His Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe
            580                 585                 590
Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Met Lys
        595                 600                 605
Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys
    610                 615                 620
Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn
625                 630                 635                 640
Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr
                645                 650                 655
Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln
            660                 665                 670
Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys
        675                 680                 685
Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val
    690                 695                 700
Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val
705                 710                 715                 720
Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr
                725                 730                 735
Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val
            740                 745                 750
Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu
        755                 760                 765
Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe
    770                 775                 780
Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp
785                 790                 795                 800
Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly
                805                 810                 815
Ser


<210> 12
<211> 780
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence anti-EPCAM trigger polypeptide

<400> 12
Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe
            20                  25                  30
Pro Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Thr Ile Ser Thr Ser Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95
Thr Arg Thr Leu Tyr Ile Leu Arg Val Phe Tyr Phe Asp Tyr Trp Gly
            100                 105                 110
Gln Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro
    130                 135                 140
Ala Ser Leu Ser Ala Ser Leu Gly Glu Thr Val Ser Ile Glu Cys Leu
145                 150                 155                 160
Ala Ser Glu Gly Ile Ser Asn Asp Leu Ala Trp Tyr Gln Gln Lys Ser
                165                 170                 175
Gly Lys Ser Pro Gln Leu Leu Ile Tyr Ala Thr Ser Arg Leu Gln Asp
            180                 185                 190
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Tyr Ser
        195                 200                 205
Leu Lys Ile Ser Gly Met Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys
    210                 215                 220
Gln Gln Ser Tyr Lys Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
225                 230                 235                 240
Glu Leu Lys Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp
                245                 250                 255
Ile Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln
            260                 265                 270
Val Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala
        275                 280                 285
Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp
    290                 295                 300
Lys Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly
305                 310                 315                 320
His Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe
                325                 330                 335
Asp Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr
            340                 345                 350
Cys Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser
        355                 360                 365
Ala Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu
    370                 375                 380
Arg Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp
385                 390                 395                 400
Gln Leu Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val
                405                 410                 415
Leu His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met
            420                 425                 430
Ile Phe Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile
        435                 440                 445
Lys Arg Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr
    450                 455                 460
Ser Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly
465                 470                 475                 480
Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser
                485                 490                 495
Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala
            500                 505                 510
Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val
        515                 520                 525
Lys Ser Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met
    530                 535                 540
Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly
545                 550                 555                 560
Val Leu Leu Ser Arg Lys Arg Arg Arg Met Lys Leu Leu Ser Ser Ile
                565                 570                 575
Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys
            580                 585                 590
Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg
        595                 600                 605
Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr
    610                 615                 620
Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile
625                 630                 635                 640
Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln
                645                 650                 655
Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn
            660                 665                 670
Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro
        675                 680                 685
Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu
    690                 695                 700
Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly
705                 710                 715                 720
Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu
                725                 730                 735
Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu
            740                 745                 750
Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp
        755                 760                 765
Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser
    770                 775                 780

<210> 13
<211> 780
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence anti-CD19 trigger polypeptide

<400> 13
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15
His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp
            20                  25                  30
Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp
        35                  40                  45
Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu
    50                  55                  60
Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr
65                  70                  75                  80
His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
                85                  90                  95
Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu
            100                 105                 110
Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr
        115                 120                 125
Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly
    130                 135                 140
Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser
145                 150                 155                 160
Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr
                165                 170                 175
Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln
            180                 185                 190
Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu
        195                 200                 205
Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys
    210                 215                 220
Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr
225                 230                 235                 240
Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly
                245                 250                 255
Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser
            260                 265                 270
Ser Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro
        275                 280                 285
Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp
    290                 295                 300
Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly
305                 310                 315                 320
Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn
                325                 330                 335
Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys
            340                 345                 350
Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys
        355                 360                 365
Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys
    370                 375                 380
Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu
385                 390                 395                 400
Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu
                405                 410                 415
Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu
            420                 425                 430
Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His
        435                 440                 445
Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe
    450                 455                 460
Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg
465                 470                 475                 480
Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly
                485                 490                 495
Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile
            500                 505                 510
Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln
        515                 520                 525
Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala
    530                 535                 540
Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser
545                 550                 555                 560
Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val
                565                 570                 575
Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu
            580                 585                 590
Leu Ser Arg Lys Arg Arg Arg Met Lys Leu Leu Ser Ser Ile Glu Gln
        595                 600                 605
Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys
    610                 615                 620
Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser
625                 630                 635                 640
Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val
                645                 650                 655
Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro
            660                 665                 670
Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile
        675                 680                 685
Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp
    690                 695                 700
Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr
705                 710                 715                 720
Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser
                725                 730                 735
Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser
            740                 745                 750
Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met
        755                 760                 765
Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp
    770                 775                 780

<210> 14
<211> 1989
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ANTI-B7-H3 TRIGGER POLYPEPTIDE
      (nucleotide: VH-linker-VL-NotchR)

<400> 14
ggatctacaa gcggctctgg caagcctgga tctggcgagg gttctaccaa gggcgatatc      60
cagatgaccc agaccaccag cagcctgtct gcctctctgg gcgatagagt gaccatcagc     120
tgcagagcca gccaggacat cagcaactac ctgaactggt atcagcaaaa gcccgacggc     180
accgtgaagc tgctgatcta ctacaccagc agactgcaca gcggcgtgcc cagcagattt     240
tctggaagcg gcagcggcac cgactacagc ctgaccatcg acaacctgga acaagaggat     300
atcgctacct acttctgcca gcaaggcaac accctgcctc caacatttgg cggaggcacc     360
aagctggaaa tcaaaatcct ggactacagc ttcacaggtg gcgctgggcg cgacattccc     420
ccaccgcaga ttgaggaggc ctgtgagctg cctgagtgcc aggtggatgc aggcaataag     480
gtctgcaacc tgcagtgtaa taatcacgca tgtggctggg atggtggcga ctgctccctc     540
aacttcaatg acccctggaa gaactgcacg cagtctctac agtgctggaa gtattttagc     600
gacggccact gtgacagcca gtgcaactcg gccggctgcc tctttgatgg cttcgactgc     660
cagctcaccg agggacagtg caaccccctg tatgaccagt actgcaagga ccacttcagt     720
gatggccact gcgaccaggg ctgtaacagt gccgaatgtg agtgggatgg cctagactgt     780
gctgagcatg tacccgagcg gctggcagcc ggcaccctgg tgctggtggt gctgcttcca     840
cccgaccagc tacggaacaa ctccttccac tttctgcggg agctcagcca cgtgctgcac     900
accaacgtgg tcttcaagcg tgatgcgcaa ggccagcaga tgatcttccc gtactatggc     960
cacgaggaag agctgcgcaa gcacccaatc aagcgctcta cagtgggttg ggccacctct    1020
tcactgcttc ctggtaccag tggtgggcgc cagcgcaggg agctggaccc catggacatc    1080
cgtggctcca ttgtctacct ggagatcgac aaccggcaat gtgtgcagtc atcctcgcag    1140
tgcttccaga gtgccaccga tgtggctgcc ttcctaggtg ctcttgcgtc acttggcagc    1200
ctcaatattc cttacaagat tgaggccgtg aagagtgagc cggtggagcc tccgctgccc    1260
tcgcagctgc acctcatgta cgtggcagcg gccgccttcg tgctcctgtt ctttgtgggc    1320
tgtggggtgc tgctgtcccg caagcgccgg cggatgaagc tgctgagcag catcgagcag    1380
gcctgtgaca tctgccggct gaagaaactg aagtgcagca aagaaaagcc caagtgcgcc    1440
aagtgcctga agaacaactg ggagtgccgg tacagcccca agaccaagag aagccccctg    1500
accagagccc acctgaccga ggtggaaagc cggctggaaa gactggaaca gctgtttctg    1560
ctgatcttcc cacgcgagga cctggacatg atcctgaaga tggacagcct gcaggacatc    1620
aaggccctgc tgaccggcct gttcgtgcag gacaacgtga acaaggacgc cgtgaccgac    1680
agactggcca gcgtggaaac cgacatgccc ctgaccctgc ggcagcacag aatcagcgcc    1740
accagcagca gcgaggaaag cagcaacaag ggccagcggc agctgacagt gtctgctgct    1800
gcaggcggaa gcggaggctc tggcggatct gatgccctgg acgacttcga cctggatatg    1860
ctgggcagcg acgccctgga tgattttgat ctggacatgc tgggatctga cgctctggac    1920
gatttcgatc tcgacatgtt gggatcagat gcactggatg actttgacct ggacatgctc    1980
ggatcatga                                                            1989

<210> 15
<211> 1980
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-EpCAM TRIGGER
      POLYPEPTIDE (nucleotide: VH-linker-VL-NotchR)

<400> 15
ggaggcggag gttctggcgg cggaggatca ggtggtggcg gatctgatat ccagatgaca      60
cagagccctg ccagcctgtc tgcttctctg ggagagacag tgtccatcga gtgtctggcc     120
agcgagggca tctctaacga cctggcctgg tatcagcaga agtccggcaa gtctccccag     180
ctgctgatct acgccacaag cagactgcag gacggcgtgc catctagatt cagcggctct     240
ggcagcggca ccagatacag cctgaagatc tctggcatgc agcccgagga cgaggccgac     300
tacttttgcc agcagagcta caagtacccc tggacctttg gcggaggcac caagctggaa     360
ctgaaaatcc tggactacag cttcacaggt ggcgctgggc gcgacattcc cccaccgcag     420
attgaggagg cctgtgagct gcctgagtgc caggtggatg caggcaataa ggtctgcaac     480
ctgcagtgta ataatcacgc atgtggctgg gatggtggcg actgctccct caacttcaat     540
gacccctgga agaactgcac gcagtctcta cagtgctgga agtattttag cgacggccac     600
tgtgacagcc agtgcaactc ggccggctgc ctctttgatg gcttcgactg ccagctcacc     660
gagggacagt gcaaccccct gtatgaccag tactgcaagg accacttcag tgatggccac     720
tgcgaccagg gctgtaacag tgccgaatgt gagtgggatg gcctagactg tgctgagcat     780
gtacccgagc ggctggcagc cggcaccctg gtgctggtgg tgctgcttcc acccgaccag     840
ctacggaaca actccttcca ctttctgcgg gagctcagcc acgtgctgca caccaacgtg     900
gtcttcaagc gtgatgcgca aggccagcag atgatcttcc cgtactatgg ccacgaggaa     960
gagctgcgca agcacccaat caagcgctct acagtgggtt gggccacctc ttcactgctt    1020
cctggtacca gtggtgggcg ccagcgcagg gagctggacc ccatggacat ccgtggctcc    1080
attgtctacc tggagatcga caaccggcaa tgtgtgcagt catcctcgca gtgcttccag    1140
agtgccaccg atgtggctgc cttcctaggt gctcttgcgt cacttggcag cctcaatatt    1200
ccttacaaga ttgaggccgt gaagagtgag ccggtggagc ctccgctgcc ctcgcagctg    1260
cacctcatgt acgtggcagc ggccgccttc gtgctcctgt tctttgtggg ctgtggggtg    1320
ctgctgtccc gcaagcgccg gcggatgaag ctgctgagca gcatcgagca ggcctgtgac    1380
atctgccggc tgaagaaact gaagtgcagc aaagaaaagc ccaagtgcgc caagtgcctg    1440
aagaacaact gggagtgccg gtacagcccc aagaccaaga gaagccccct gaccagagcc    1500
cacctgaccg aggtggaaag ccggctggaa agactggaac agctgtttct gctgatcttc    1560
ccacgcgagg acctggacat gatcctgaag atggacagcc tgcaggacat caaggccctg    1620
ctgaccggcc tgttcgtgca ggacaacgtg aacaaggacg ccgtgaccga cagactggcc    1680
agcgtggaaa ccgacatgcc cctgaccctg cggcagcaca gaatcagcgc caccagcagc    1740
agcgaggaaa gcagcaacaa gggccagcgg cagctgacag tgtctgctgc tgcaggcgga    1800
agcggaggct ctggcggatc tgatgccctg gacgacttcg acctggatat gctgggcagc    1860
gacgccctgg atgattttga tctggacatg ctgggatctg acgctctgga cgatttcgat    1920
ctcgacatgt tgggatcaga tgcactggat gactttgacc tggacatgct cggatcatga    1980

<210> 16
<211> 2854
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-EpCAM TRIGGER
      POLYPEPTIDE (nucleotide: PGK promoter-CD8a
      signal-Myc tag-VH-linker-VL-NotchR)

<400> 16
ccggtaggcg ccaaccggct ccgttctttg gtggcccctt cgcgccacct tctactcctc      60
ccctagtcag gaagttcccc cccgccccgc agctcgcgtc gtgcaggacg tgacaaatgg     120
aagtagcacg tctcactagt ctcgtgcaga tggacagcac cgctgagcaa tggaagcggg     180
taggcctttg gggcagcggc caatagcagc tttgctcctt cgctttctgg gctcagaggc     240
tgggaagggg tgggtccggg ggcgggctca ggggcggggc gggcgcccga aggtcctccg     300
gaggcccggc attctgcacg cttcaaaagc gcacgtctgc cgcgctgttc tcctcttcct     360
catctccggg cctttcgaat tctcacgcgt caagtggagc aaggcaggtg gacagtggat     420
catggcgctc cctgtcaccg cactgcttct tccgctggca ctgctgctgc acgctgcacg     480
gcctgagcaa aaacttatct ctgaagagga cctcgatata cagatgacgc agacaacgtc     540
aagtctttcc gccagcttgg gagaccgagt gactatatct tgtagagcaa gccaggatat     600
ttctaagtat cttaactggt accaacaaaa gcccgatgga acggttaagc tgcttatata     660
ccataccagt agactccact ccggcgtacc atcacggttt tctggcagtg gctccgggac     720
cgactattct ttgacgatct ctaatctcga acaagaggat attgcaacat acttttgtca     780
gcaaggcaat accttgccat atacgtttgg gggcgggaca aaacttgaga taaccggcgg     840
cggtggttca ggcggtggcg gttccggtgg tgggggatca gaggttaagc ttcaggaatc     900
cggaccaggt ttggttgccc ccagccaatc tctcagcgtt acatgcacgg tttcaggcgt     960
cagtctcccc gattacggtg taagttggat tcggcaacct ccgcgaaagg gtctggaatg    1020
gctgggggtt atttggggga gtgagacaac ttattacaac tctgcactta agagtcggct    1080
taccatcatc aaggataatt caaaatcaca agtattcctg aagatgaact cattgcaaac    1140
agatgataca gctatatact attgtgccaa gcattactat tatggtggtt cttatgcaat    1200
ggattactgg gggcaaggca cgtcagtgac agtgagttca atcctggact acagcttcac    1260
aggtggcgct gggcgcgaca ttcccccacc gcagattgag gaggcctgtg agctgcctga    1320
gtgccaggtg gatgcaggca ataaggtctg caacctgcag tgtaataatc acgcatgtgg    1380
ctgggatggt ggcgactgct ccctcaactt caatgacccc tggaagaact gcacgcagtc    1440
tctacagtgc tggaagtatt ttagcgacgg ccactgtgac agccagtgca actcggccgg    1500
ctgcctcttt gatggcttcg actgccagct caccgaggga cagtgcaacc ccctgtatga    1560
ccagtactgc aaggaccact tcagtgatgg ccactgcgac cagggctgta acagtgccga    1620
atgtgagtgg gatggcctag actgtgctga gcatgtaccc gagcggctgg cagccggcac    1680
cctggtgctg gtggtgctgc ttccacccga ccagctacgg aacaactcct tccactttct    1740
gcgggagctc agccacgtgc tgcacaccaa cgtggtcttc aagcgtgatg cgcaaggcca    1800
gcagatgatc ttcccgtact atggccacga ggaagagctg cgcaagcacc caatcaagcg    1860
ctctacagtg ggttgggcca cctcttcact gcttcctggt accagtggtg ggcgccagcg    1920
cagggagctg gaccccatgg acatccgtgg ctccattgtc tacctggaga tcgacaaccg    1980
gcaatgtgtg cagtcatcct cgcagtgctt ccagagtgcc accgatgtgg ctgccttcct    2040
aggtgctctt gcgtcacttg gcagcctcaa tattccttac aagattgagg ccgtgaagag    2100
tgagccggtg gagcctccgc tgccctcgca gctgcacctc atgtacgtgg cagcggccgc    2160
cttcgtgctc ctgttctttg tgggctgtgg ggtgctgctg tcccgcaagc gccggcggat    2220
gaagctgctg agcagcatcg agcaggcctg tgacatctgc cggctgaaga aactgaagtg    2280
cagcaaagaa aagcccaagt gcgccaagtg cctgaagaac aactgggagt gccggtacag    2340
ccccaagacc aagagaagcc ccctgaccag agcccacctg accgaggtgg aaagccggct    2400
ggaaagactg gaacagctgt ttctgctgat cttcccacgc gaggacctgg acatgatcct    2460
gaagatggac agcctgcagg acatcaaggc cctgctgacc ggcctgttcg tgcaggacaa    2520
cgtgaacaag gacgccgtga ccgacagact ggccagcgtg gaaaccgaca tgcccctgac    2580
cctgcggcag cacagaatca gcgccaccag cagcagcgag gaaagcagca acaagggcca    2640
gcggcagctg acagtgtctg ctgctgcagg cggaagcgga ggctctggcg gatctgatgc    2700
cctggacgac ttcgacctgg atatgctggg cagcgacgcc ctggatgatt ttgatctgga    2760
catgctggga tctgacgctc tggacgattt cgatctcgac atgttgggat cagatgcact    2820
ggatgacttt gacctggaca tgctcggatc atga                                2854

<210> 17
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R11 ANTIBODY CDRH1

<400> 17
Asp Tyr Pro Ile Ser
 1               5

<210> 18
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R11 ANTIBODY CDRH2

<400> 18
Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly
 1               5                  10                  15

<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R11 ANTIBODY CDRH3

<400> 19
Gly Tyr Ser Thr Tyr Tyr Gly Asp Phe Asn Ile
 1               5                  10

<210> 20
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R11 ANTIBODY CDRL1

<400> 20
Gln Ala Ser Gln Ser Ile Asp Ser Asn Leu Ala
 1               5                  10

<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R11 ANTIBODY CDRL2

<400> 21
Arg Ala Ser Asn Leu Ala Ser
 1               5

<210> 22
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R11 ANTIBODY CDRL3

<400> 22
Leu Gly Gly Val Gly Asn Val Ser Tyr Arg Thr Ser
 1               5                  10

<210> 23
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R11 ANTIBODY VH

<400> 23
Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala Gly Asn
 1               5                  10                  15
Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr Pro
            20                  25                  30
Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45
Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly
    50                  55                  60
Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr
65                  70                  75                  80
Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr
                85                  90                  95
Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu Val
            100                 105                 110
Thr Ile Ser Ser
        115

<210> 24
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R11 ANTIBODY VL

<400> 24
Glu Leu Val Met Thr Gln Thr Pro Ser Ser Thr Ser Gly Ala Val Gly
 1               5                  10                  15
Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn
            20                  25                  30
Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Thr Leu Leu Ile
        35                  40                  45
Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Arg Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Arg
65                  70                  75                  80
Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Asn Val Ser
                85                  90                  95
Tyr Arg Thr Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys
            100                 105                 110

<210> 25
<211> 241
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R11 SCFV

<400> 25
Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala Gly Asn
 1               5                  10                  15
Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr Pro
            20                  25                  30
Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45
Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly
    50                  55                  60
Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr
65                  70                  75                  80
Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr
                85                  90                  95
Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu Val
            100                 105                 110
Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125
Gly Gly Ser Glu Leu Val Met Thr Gln Thr Pro Ser Ser Thr Ser Gly
    130                 135                 140
Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile
145                 150                 155                 160
Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Thr
                165                 170                 175
Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg
            180                 185                 190
Phe Ser Gly Ser Arg Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly
        195                 200                 205
Val Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly
    210                 215                 220
Asn Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr Glu Val Val Val
225                 230                 235                 240
Lys


<210> 26
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Y31 ANTIBODY CDRH1

<400> 26
Ser His Trp Met Ser
 1               5

<210> 27
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Y31 ANTIBODY CDRH2

<400> 27
Ile Ile Ala Ala Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly
 1               5                  10                  15

<210> 28
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Y31 ANTIBODY CDRH3

<400> 28
Asp Tyr Gly Asp Tyr Arg Leu Val Thr Phe Asn Ile
 1               5                  10

<210> 29
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Y31 ANTIBODY CDRL1

<400> 29
Gln Ala Ser Gln Ser Ile Gly Ser Tyr Leu Ala
 1               5                  10

<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Y31 ANTIBODY CDRL2

<400> 30
Tyr Ala Ser Asn Leu Ala Ser
 1               5

<210> 31
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Y31 ANTIBODY CDRL3

<400> 31
Leu Gly Ser Leu Asn Ser Asp Asn Val
 1               5

<210> 32
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 2A2 ANTIBODY CDRH1

<400> 32
Asp Tyr Glu Met His
 1               5

<210> 33
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 2A2 ANTIBODY CDRH2

<400> 33
Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15
Gly


<210> 34
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 2A2 ANTIBODY CDRH3

<400> 34
Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr
 1               5

<210> 35
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 2A2 ANTIBODY CDRL1

<400> 35
Lys Ala Ser Gln Asn Val Asp Ala Ala Val Ala
 1               5                  10

<210> 36
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 2A2 ANTIBODY CDRL2

<400> 36
Ser Ala Ser Asn Arg Tyr Thr
 1               5

<210> 37
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 2A2 ANTIBODY CDRL3

<400> 37
Gln Gln Tyr Asp Ile Tyr Pro Tyr Thr
 1               5

<210> 38
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 2A2 ANTIBODY VH

<400> 38
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr
            20                  25                  30
Glu Met His Trp Val Ile Gln Thr Pro Val His Gly Leu Glu Trp Ile
        35                  40                  45
Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
    50                  55                  60
Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95
Thr Gly Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ala
        115

<210> 39
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 2A2 ANTIBODY VL

<400> 39
Asp Ile Val Met Thr Gln Ser Gln Lys Ile Met Ser Thr Thr Val Gly
 1               5                  10                  15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Ala Ala
            20                  25                  30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45
Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser
65                  70                  75                  80
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asp Ile Tyr Pro Tyr
                85                  90                  95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105

<210> 40
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 2A2 SCFV

<400> 40
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr
            20                  25                  30
Glu Met His Trp Val Ile Gln Thr Pro Val His Gly Leu Glu Trp Ile
        35                  40                  45
Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
    50                  55                  60
Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95
Thr Gly Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly
        115                 120                 125
Gly Ser Asp Ile Val Met Thr Gln Ser Gln Lys Ile Met Ser Thr Thr
    130                 135                 140
Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Asp
145                 150                 155                 160
Ala Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu
                165                 170                 175
Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe
            180                 185                 190
Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met
        195                 200                 205
Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asp Ile Tyr
    210                 215                 220
Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
225                 230                 235

<210> 41
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R12 ANTIBODY CDRH1

<400> 41
Ala Tyr Tyr Met Ser
 1               5

<210> 42
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R12 ANTIBODY CDRH2

<400> 42
Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val Asn
 1               5                  10                  15
Gly


<210> 43
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R12 ANTIBODY CDRH3

<400> 43
Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile
 1               5                  10

<210> 44
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R12 ANTIBODY CDRL1

<400> 44
Thr Leu Ser Ser Ala His Lys Thr Asp Thr Ile Asp
 1               5                  10

<210> 45
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R12 ANTIBODY CDRL2

<400> 45
Gly Ser Tyr Thr Lys Arg Pro
 1               5

<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R12 ANTIBODY CDRL3

<400> 46
Gly Ala Asp Tyr Ile Gly Gly Tyr Val
 1               5

<210> 47
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R12 ANTIBODY VH

<400> 47
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly
 1               5                  10                  15
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr
            20                  25                  30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val
    50                  55                  60
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys
                85                  90                  95
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly
            100                 105                 110
Pro Gly Thr Leu Val Thr Ile Ser Ser
        115                 120

<210> 48
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R12 ANTIBODY VL

<400> 48
Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ser
 1               5                  10                  15
Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala His Lys Thr Asp Thr
            20                  25                  30
Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala Pro Arg Tyr Leu Met
        35                  40                  45
Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp
    50                  55                  60
Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro
65                  70                  75                  80
Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Tyr
                85                  90                  95
Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly
            100                 105                 110

<210> 49
<211> 248
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - R12 SCFV

<400> 49
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly
 1               5                  10                  15
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr
            20                  25                  30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val
    50                  55                  60
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys
                85                  90                  95
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly
            100                 105                 110
Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125
Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Ser Pro
    130                 135                 140
Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu
145                 150                 155                 160
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln
                165                 170                 175
Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr
            180                 185                 190
Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly
        195                 200                 205
Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala
    210                 215                 220
Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly
225                 230                 235                 240
Gly Thr Gln Leu Thr Val Thr Gly
                245

<210> 50
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-ROR1 SCFV CDRH1

<400> 50
Asp Thr Ile Asp Trp Tyr
 1               5

<210> 51
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-ROR1 SCFV CDRH2

<400> 51
Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp Arg
 1               5                  10                  15

<210> 52
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-ROR1 SCFV CDRH3

<400> 52
Tyr Ile Gly Gly Tyr Val Phe Gly
 1               5

<210> 53
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-ROR1 SCFV CDRL1

<400> 53
Ala Ser Gly Phe Asp Phe Ser Ala Tyr Tyr Met
 1               5                  10

<210> 54
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-ROR1 SCFV CDRL2

<400> 54
Thr Ile Tyr Pro Ser Ser Gly
 1               5

<210> 55
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-ROR1 SCFV CDRL3

<400> 55
Ala Asp Arg Ala Thr Tyr Phe Cys Ala
 1               5

<210> 56
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-ROR1 SCFV CDRH1

<400> 56
Ser Asn Leu Ala Trp
 1               5

<210> 57
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-ROR1 SCFV CDRH2

<400> 57
Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
 1               5                  10                  15

<210> 58
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-ROR1 SCFV CDRH3

<400> 58
Asn Val Ser Tyr Arg Thr Ser Phe
 1               5

<210> 59
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-ROR1 SCFV CDRL1

<400> 59
Ser Gly Ser Asp Ile Asn Asp Tyr Pro Ile Ser
 1               5                  10

<210> 60
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-ROR1 SCFV CDRL2

<400> 60
Ile Asn Ser Gly Gly Ser Thr
 1               5

<210> 61
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-ROR1 SCFV CDRL3

<400> 61
Tyr Phe Cys Ala Arg Gly Tyr Ser
 1               5

<210> 62
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - AMINO ACID SPACER

<400> 62
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
 1               5                  10

<210> 63
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - AMINO ACID SPACER

<400> 63
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro
 1               5                  10

<210> 64
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - AMINO ACID SPACER

<400> 64
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15

<210> 65
<211> 339
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - IGG4 FC WITH SPACER

<400> 65
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Ser Thr Lys
 1               5                  10                  15
Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu
            20                  25                  30
Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
        35                  40                  45
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
    50                  55                  60
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
65                  70                  75                  80
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn
                85                  90                  95
Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser
            100                 105                 110
Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly
        115                 120                 125
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    130                 135                 140
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln
145                 150                 155                 160
Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                165                 170                 175
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr
            180                 185                 190
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        195                 200                 205
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile
    210                 215                 220
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
225                 230                 235                 240
Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser
                245                 250                 255
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            260                 265                 270
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        275                 280                 285
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val
    290                 295                 300
Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met
305                 310                 315                 320
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                325                 330                 335
Leu Gly Lys


<210> 66
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - HUCD28 TRANSMEMBRANE DOMAIN

<400> 66
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
 1               5                  10                  15
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25

<210> 67
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - HU4-1BB EFFECTOR DOMAIN

<400> 67
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
 1               5                  10                  15
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
            20                  25                  30
Pro Glu Glu Glu Glu Gly Gly Cys Glu
        35                  40

<210> 68
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - HUCD3Z EFFECTOR DOMAIN

<400> 68
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln
 1               5                  10                  15
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
            20                  25                  30
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
        35                  40                  45
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln
    50                  55                  60
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu
65                  70                  75                  80
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
                85                  90                  95
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro
            100                 105                 110
Arg


<210> 69
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - HUEGFRT EXPRESSION MARKER

<400> 69
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu
 1               5                  10                  15
Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile
            20                  25                  30
Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe
        35                  40                  45
Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr
    50                  55                  60
Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn
65                  70                  75                  80
Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg
                85                  90                  95
Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile
            100                 105                 110
Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val
        115                 120                 125
Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp
    130                 135                 140
Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn
145                 150                 155                 160
Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu
                165                 170                 175
Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser
            180                 185                 190
Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu
        195                 200                 205
Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln
    210                 215                 220
Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly
225                 230                 235                 240
Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro
                245                 250                 255
His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr
            260                 265                 270
Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His
        275                 280                 285
Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro
    290                 295                 300
Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala
305                 310                 315                 320
Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met
                325                 330                 335

<210> 70
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - THOSEA ASIGNA VIRUS 2A (T2A)
      SELF-CLEAVING ELEMENT

<400> 70
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro
 1               5                  10                  15
Gly Pro


<210> 71
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - T2A, MODIFIED

<400> 71
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu
 1               5                  10                  15
Glu Asn Pro Gly Pro
            20

<210> 72
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - PORCINE TESCHOVIRUS-1 2A
      (P2A) SELF-CLEAVING ELEMENT

<400> 72
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn
 1               5                  10                  15
Pro Gly Pro


<210> 73
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - P2A, MODIFIED

<400> 73
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
 1               5                  10                  15
Glu Glu Asn Pro Gly Pro
            20

<210> 74
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - EQUINE RHINITIS A VIRUS 2A
      (E2A) SELF-CLEAVING ELEMENT

<400> 74
Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Ser Asp Val Glu
 1               5                  10                  15
Ser Asn Pro Gly Pro
            20

<210> 75
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - E2A, MODIFIED

<400> 75
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Ser
 1               5                  10                  15
Asp Val Glu Ser Asn Pro Gly Pro
            20

<210> 76
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - FOOT-AND-MOUTH DISEASE VIRUS
      2A (F2A) SELF-CLEAVING ELEMENT

<400> 76
Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val
 1               5                  10                  15
Glu Ser Asn Pro Gly Pro
            20

<210> 77
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - T2A, MODIFIED

<400> 77
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala
 1               5                  10                  15
Gly Asp Val Glu Ser Asn Pro Gly Pro
            20                  25

<210> 78
<211> 1054
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - HUMAN R11 ANTI-ROR1 CAR
      EXPRESSION PRODUCT) [SIGNAL-R11VH-LINKER-
      R11VL-IGG4HINGE-CH2-CH3-huCD28TM- hu4-1BB EFFECTOR
      - huCD3z EFFECTOR-T2A-SIGNAL-TEGFR]

<400> 78
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15
Ala Phe Leu Leu Ile Pro Gln Ser Val Lys Glu Ser Glu Gly Asp Leu
            20                  25                  30
Val Thr Pro Ala Gly Asn Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser
        35                  40                  45
Asp Ile Asn Asp Tyr Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Lys
    50                  55                  60
Gly Leu Glu Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr
65                  70                  75                  80
Ala Ser Trp Val Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr
                85                  90                  95
Val Asp Leu Lys Met Thr Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr
            100                 105                 110
Phe Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp
        115                 120                 125
Gly Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly
    130                 135                 140
Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Thr
145                 150                 155                 160
Pro Ser Ser Thr Ser Gly Ala Val Gly Gly Thr Val Thr Ile Asn Cys
                165                 170                 175
Gln Ala Ser Gln Ser Ile Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys
            180                 185                 190
Pro Gly Gln Pro Pro Thr Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala
        195                 200                 205
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Glu Tyr
    210                 215                 220
Thr Leu Thr Ile Ser Gly Val Gln Arg Glu Asp Ala Ala Thr Tyr Tyr
225                 230                 235                 240
Cys Leu Gly Gly Val Gly Asn Val Ser Tyr Arg Thr Ser Phe Gly Gly
                245                 250                 255
Gly Thr Glu Val Val Val Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro
            260                 265                 270
Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro
        275                 280                 285
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
    290                 295                 300
Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
305                 310                 315                 320
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                325                 330                 335
Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
            340                 345                 350
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
        355                 360                 365
Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
    370                 375                 380
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
385                 390                 395                 400
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                405                 410                 415
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
            420                 425                 430
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
        435                 440                 445
Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
    450                 455                 460
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
465                 470                 475                 480
Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu
                485                 490                 495
Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
            500                 505                 510
Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr
        515                 520                 525
Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu
    530                 535                 540
Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu
545                 550                 555                 560
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln
                565                 570                 575
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
            580                 585                 590
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
        595                 600                 605
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln
    610                 615                 620
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu
625                 630                 635                 640
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
                645                 650                 655
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro
            660                 665                 670
Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly
        675                 680                 685
Asp Val Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser
    690                 695                 700
Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg
705                 710                 715                 720
Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser
                725                 730                 735
Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser
            740                 745                 750
Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr
        755                 760                 765
His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val
    770                 775                 780
Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg
785                 790                 795                 800
Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr
                805                 810                 815
Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr
            820                 825                 830
Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile
        835                 840                 845
Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys
    850                 855                 860
Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg
865                 870                 875                 880
Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys
                885                 890                 895
Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys
            900                 905                 910
Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu
        915                 920                 925
Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys
    930                 935                 940
His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg
945                 950                 955                 960
Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His
                965                 970                 975
Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu
            980                 985                 990
Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro
        995                 1000                1005
Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr
    1010                1015                1020
Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu
1025                1030                1035                1040
Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met
                1045                1050

<210> 79
<211> 652
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - HUMAN R11 ANTI-ROR1 CAR)
      [R11VH-LINKER-R11VL-IGG4HINGE-CH2-CH3- huCD28TM-
      hu4-1BB EFFECTOR- huCD3z EFFECTOR

<400> 79
Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala Gly Asn
 1               5                  10                  15
Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr Pro
            20                  25                  30
Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45
Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly
    50                  55                  60
Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr
65                  70                  75                  80
Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr
                85                  90                  95
Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu Val
            100                 105                 110
Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125
Gly Gly Ser Glu Leu Val Met Thr Gln Thr Pro Ser Ser Thr Ser Gly
    130                 135                 140
Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile
145                 150                 155                 160
Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Thr
                165                 170                 175
Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg
            180                 185                 190
Phe Ser Gly Ser Arg Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly
        195                 200                 205
Val Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly
    210                 215                 220
Asn Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr Glu Val Val Val
225                 230                 235                 240
Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro
                245                 250                 255
Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            260                 265                 270
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        275                 280                 285
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
    290                 295                 300
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser
305                 310                 315                 320
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
                325                 330                 335
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
            340                 345                 350
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
        355                 360                 365
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
    370                 375                 380
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
385                 390                 395                 400
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                405                 410                 415
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
            420                 425                 430
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
        435                 440                 445
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    450                 455                 460
Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val Val Gly Gly Val
465                 470                 475                 480
Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
                485                 490                 495
Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe
            500                 505                 510
Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg
        515                 520                 525
Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser
    530                 535                 540
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr
545                 550                 555                 560
Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys
                565                 570                 575
Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn
            580                 585                 590
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu
        595                 600                 605
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly
    610                 615                 620
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr
625                 630                 635                 640
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu
                645                 650

<210> 80
<211> 3165
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - HUMAN R11 ANTI-ROR1 CAR
      coding sequence)
      [SIGNAL-R11VH-LINKER-R11VL-IGG4HINGE-CH2-CH3-HuCD2
      8TM-hu4-1BB EFFECTOR-huCD3z EFFECTOR-T2A-PGK-TEGFR

<400> 80
atgctgctgc tggtgacaag cctgctgctg tgcgagctgc cccaccccgc ctttctgctg      60
atcccccaga gcgtgaaaga gtccgagggc gacctggtca caccagccgg caacctgacc     120
ctgacctgta ccgccagcgg cagcgacatc aacgactacc ccatctcttg ggtccgccag     180
gctcctggca agggactgga atggatcggc ttcatcaaca gcggcggcag cacttggtac     240
gccagctggg tcaaaggccg gttcaccatc agccggacca gcaccaccgt ggacctgaag     300
atgacaagcc tgaccaccga cgacaccgcc acctactttt gcgccagagg ctacagcacc     360
tactacggcg acttcaacat ctggggccct ggcaccctgg tcacaatctc tagcggcgga     420
ggcggcagcg gaggtggagg aagtggcggc ggaggatccg agctggtcat gacccagacc     480
cccagcagca catctggcgc cgtgggcggc accgtgacca tcaattgcca ggccagccag     540
agcatcgaca gcaacctggc ctggttccag cagaagcccg gccagccccc caccctgctg     600
atctacagag cctccaacct ggccagcggc gtgccaagca gattcagcgg cagcagatct     660
ggcaccgagt acaccctgac catctccggc gtgcagagag aggacgccgc tacctattac     720
tgcctgggcg gcgtgggcaa cgtgtcctac agaaccagct tcggcggagg tactgaggtg     780
gtcgtcaaag aatctaagta cggaccgcct tgcccaccgt gcccagcacc acctgtggca     840
ggaccgtcag tcttcctctt cccaccaaaa cccaaggaca ccctgatgat cagccggacc     900
cccgaggtga cctgcgtggt ggtggacgtg agccaggaag atcccgaggt ccagttcaat     960
tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcccagaga ggaacagttc    1020
caaagcacct accgggtggt gtctgtgctg accgtgctgc accaggactg gctgaacggc    1080
aaagaataca agtgcaaggt gtccaacaag ggcctgccca gcagcatcga aaagaccatc    1140
agcaaggcca agggccagcc tcgcgagccc caggtgtaca ccctgcctcc ctcccaggaa    1200
gagatgacca agaaccaggt gtccctgacc tgcctggtga agggcttcta ccccagcgac    1260
atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac cacccctccc    1320
gtgctggaca gcgacggcag cttcttcctg tacagccggc tgaccgtgga caagagccgg    1380
tggcaggaag gcaacgtctt tagctgcagc gtgatgcacg aggccctgca caaccactac    1440
acccagaaga gcctgagcct gtccctgggc aagatgttct gggtgctggt ggtggtgggc    1500
ggggtgctgg cctgctacag cctgctggtg acagtggcct tcatcatctt ttgggtgaaa    1560
cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact    1620
actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa    1680
ctgcgggtga agttcagcag aagcgccgac gcccctgcct accagcaggg ccagaatcag    1740
ctgtacaacg agctgaacct gggcagaagg gaagagtacg acgtcctgga taagcggaga    1800
ggccgggacc ctgagatggg cggcaagcct cggcggaaga acccccagga aggcctgtat    1860
aacgaactgc agaaagacaa gatggccgag gcctacagcg agatcggcat gaagggcgag    1920
cggaggcggg gcaagggcca cgacggcctg tatcagggcc tgtccaccgc caccaaggat    1980
acctacgacg ccctgcacat gcaggccctg cccccaaggc tcgagggcgg cggagagggc    2040
agaggaagtc ttctaacatg cggtgacgtg gaggagaatc ccggccctag gatgcttctc    2100
ctggtgacaa gccttctgct ctgtgagtta ccacacccag cattcctcct gatcccacgc    2160
aaagtgtgta acggaatagg tattggtgaa tttaaagact cactctccat aaatgctacg    2220
aatattaaac acttcaaaaa ctgcacctcc atcagtggcg atctccacat cctgccggtg    2280
gcatttaggg gtgactcctt cacacatact cctcctctgg atccacagga actggatatt    2340
ctgaaaaccg taaaggaaat cacagggttt ttgctgattc aggcttggcc tgaaaacagg    2400
acggacctcc atgcctttga gaacctagaa atcatacgcg gcaggaccaa gcaacatggt    2460
cagttttctc ttgcagtcgt cagcctgaac ataacatcct tgggattacg ctccctcaag    2520
gagataagtg atggagatgt gataatttca ggaaacaaaa atttgtgcta tgcaaataca    2580
ataaactgga aaaaactgtt tgggacctcc ggtcagaaaa ccaaaattat aagcaacaga    2640
ggtgaaaaca gctgcaaggc cacaggccag gtctgccatg ccttgtgctc ccccgagggc    2700
tgctggggcc cggagcccag ggactgcgtc tcttgccgga atgtcagccg aggcagggaa    2760
tgcgtggaca agtgcaacct tctggagggt gagccaaggg agtttgtgga gaactctgag    2820
tgcatacagt gccacccaga gtgcctgcct caggccatga acatcacctg cacaggacgg    2880
ggaccagaca actgtatcca gtgtgcccac tacattgacg gcccccactg cgtcaagacc    2940
tgcccggcag gagtcatggg agaaaacaac accctggtct ggaagtacgc agacgccggc    3000
catgtgtgcc acctgtgcca tccaaactgc acctacggat gcactgggcc aggtcttgaa    3060
ggctgtccaa cgaatgggcc taagatcccg tccatcgcca ctgggatggt gggggccctc    3120
ctcttgctgc tggtggtggc cctggggatc ggcctcttca tgtga                    3165

<210> 81
<211> 1024
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - MURINE R11 ANTI-ROR1 CAR
      EXPRESSION PRODUCT)[SIGNAL-R11VH-LINKER-R11VL
      -IGG4HINGE-CH2-CH3-mCD28 TM-m4-1BB EFFECTOR-mCD3z
      EFFECTOR-P2A-SIGNAL-TCD19]

<400> 81
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu
 1               5                  10                  15
Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Gln Ser Val Lys Glu
            20                  25                  30
Ser Glu Gly Asp Leu Val Thr Pro Ala Gly Asn Leu Thr Leu Thr Cys
        35                  40                  45
Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr Pro Ile Ser Trp Val Arg
    50                  55                  60
Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Phe Ile Asn Ser Gly
65                  70                  75                  80
Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly Arg Phe Thr Ile Ser
                85                  90                  95
Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr Ser Leu Thr Thr Asp
            100                 105                 110
Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Gly
        115                 120                 125
Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser Ser Gly
    130                 135                 140
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu
145                 150                 155                 160
Val Met Thr Gln Thr Pro Ser Ser Thr Ser Gly Ala Val Gly Gly Thr
                165                 170                 175
Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn Leu Ala
            180                 185                 190
Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Thr Leu Leu Ile Tyr Arg
        195                 200                 205
Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg
    210                 215                 220
Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Arg Glu Asp
225                 230                 235                 240
Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Asn Val Ser Tyr Arg
                245                 250                 255
Thr Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys Glu Ser Lys Tyr
            260                 265                 270
Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser
        275                 280                 285
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    290                 295                 300
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro
305                 310                 315                 320
Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                325                 330                 335
Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val
            340                 345                 350
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        355                 360                 365
Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr
    370                 375                 380
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
385                 390                 395                 400
Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
                405                 410                 415
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            420                 425                 430
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        435                 440                 445
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser
    450                 455                 460
Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
465                 470                 475                 480
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
                485                 490                 495
Phe Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu
            500                 505                 510
Leu Val Thr Val Ala Leu Cys Val Ile Trp Thr Leu Lys Trp Ile Arg
        515                 520                 525
Lys Lys Phe Pro His Ile Phe Lys Gln Pro Phe Lys Lys Thr Thr Gly
    530                 535                 540
Ala Ala Gln Glu Glu Asp Ala Cys Ser Cys Arg Cys Pro Gln Glu Glu
545                 550                 555                 560
Glu Gly Gly Gly Gly Gly Tyr Glu Leu Arg Ala Lys Phe Ser Arg Ser
                565                 570                 575
Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu
            580                 585                 590
Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg
        595                 600                 605
Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro
    610                 615                 620
Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala
625                 630                 635                 640
Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His
                645                 650                 655
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp
            660                 665                 670
Ala Leu His Met Gln Thr Leu Ala Pro Arg Gly Ser Gly Ala Thr Asn
        675                 680                 685
Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro
    690                 695                 700
Met Pro Ser Pro Leu Pro Val Ser Phe Leu Leu Phe Leu Thr Leu Val
705                 710                 715                 720
Gly Gly Arg Pro Gln Lys Ser Leu Leu Val Glu Val Glu Glu Gly Gly
                725                 730                 735
Asn Val Val Leu Pro Cys Leu Pro Asp Ser Ser Pro Val Ser Ser Glu
            740                 745                 750
Lys Leu Ala Trp Tyr Arg Gly Asn Gln Ser Thr Pro Phe Leu Glu Leu
        755                 760                 765
Ser Pro Gly Ser Pro Gly Leu Gly Leu His Val Gly Ser Leu Gly Ile
    770                 775                 780
Leu Leu Val Ile Val Asn Val Ser Asp His Met Gly Gly Phe Tyr Leu
785                 790                 795                 800
Cys Gln Lys Arg Pro Pro Phe Lys Asp Ile Trp Gln Pro Ala Trp Thr
                805                 810                 815
Val Asn Val Glu Asp Ser Gly Glu Met Phe Arg Trp Asn Ala Ser Asp
            820                 825                 830
Val Arg Asp Leu Asp Cys Asp Leu Arg Asn Arg Ser Ser Gly Ser His
        835                 840                 845
Arg Ser Thr Ser Gly Ser Gln Leu Tyr Val Trp Ala Lys Asp His Pro
    850                 855                 860
Lys Val Trp Gly Thr Lys Pro Val Cys Ala Pro Arg Gly Ser Ser Leu
865                 870                 875                 880
Asn Gln Ser Leu Ile Asn Gln Asp Leu Thr Val Ala Pro Gly Ser Thr
                885                 890                 895
Leu Trp Leu Ser Cys Gly Val Pro Pro Val Pro Val Ala Lys Gly Ser
            900                 905                 910
Ile Ser Trp Thr His Val His Pro Arg Arg Pro Asn Val Ser Leu Leu
        915                 920                 925
Ser Leu Ser Leu Gly Gly Glu His Pro Val Arg Glu Met Trp Val Trp
    930                 935                 940
Gly Ser Leu Leu Leu Leu Pro Gln Ala Thr Ala Leu Asp Glu Gly Thr
945                 950                 955                 960
Tyr Tyr Cys Leu Arg Gly Asn Leu Thr Ile Glu Arg His Val Lys Val
                965                 970                 975
Ile Ala Arg Ser Val Trp Leu Trp Leu Leu Arg Thr Gly Gly Trp Ile
            980                 985                 990
Val Pro Val Val Thr Leu Val Tyr Val Ile Phe Cys Met Val Ser Leu
        995                 1000                1005
Val Ala Phe Leu Tyr Cys Gln Arg Ala Phe Ile Leu Arg Arg Lys Arg
    1010                1015                1020

<210> 82
<211> 3075
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - MURINE R11 ANTI-ROR1 CAR
      coding sequence)
      [SIGNAL-R11VH-LINKER-R11VL-IGG4HINGE-CH2-CH3-MCD28
      TM-M4-1BB EFFECTOR-mCD3z EFFECTOR-P2A-PGK-TCD19]

<400> 82
atggctagtc ctctgaccag attcctgagc ctgaacctgc tgctgctggg cgagagcatc      60
atcctgggat ctggcgaggc ccagagcgtg aaagagtctg agggcgacct cgtgacccct     120
gccggaaacc tgaccctgac ctgtacagcc agcggcagcg acatcaacga ctaccccatc     180
agctgggtgc gacaggctcc tggcaagggc ctggaatgga tcggcttcat caacagcggc     240
ggcagcactt ggtacgcctc ttgggtcaag ggcagattca ccatcagcag aaccagcacc     300
accgtggacc tgaagatgac cagcctgacc accgacgaca ccgccaccta cttttgcgcc     360
agaggctaca gcacctacta cggcgacttc aacatctggg gccctggcac cctcgtgaca     420
atctcttctg gcggcggagg aagcggaggc ggaggatctg ggggaggcgg atctgagctc     480
gtgatgaccc agacccctag cagcacatct ggcgctgtgg gcggcaccgt gaccatcaac     540
tgtcaggcca gccagagcat cgacagcaac ctggcctggt tccagcagaa gcctggccag     600
cctcctaccc tgctgatcta cagagccagc aatctggcca gcggcgtgcc cagcagattc     660
agcggctcta gaagcggcac cgagtacacc ctgaccatct ccggcgtgca gagagaggac     720
gccgctacct actactgtct gggcggcgtg ggcaacgtgt cctacaggac atctttcggc     780
ggaggcaccg aggtggtcgt gaaagaatct aagtacggac cgccctgccc cccctgtcct     840
gctccaccgg tggctggccc tagcgtgttc ctgttccccc caaagcccaa ggacaccctg     900
atgatctcca ggacccccga agtgacctgc gtggtggtgg atgtgtccca ggaagatccc     960
gaggtgcagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagccc    1020
agagaggaac agttccagag cacctacaga gtggtgtccg tgctgaccgt gctgcaccag    1080
gattggctga acggcaaaga gtacaagtgc aaggtgtcca acaagggact gcccagctcc    1140
atcgaaaaga caatcagcaa ggccaaggga cagcctcgcg agccccaggt gtacacactg    1200
cctccaagcc aggaagagat gaccaagaac caggtgtccc tgacatgcct cgtgaagggc    1260
ttctacccct ccgatatcgc cgtggaatgg gagagcaacg gccagcccga gaacaactac    1320
aagaccaccc ctcccgtgct ggactccgac ggctcattct tcctgtactc cagactgacc    1380
gtggacaaga gcagatggca ggaaggcaat gtgttcagct gcagcgtgat gcacgaggcc    1440
ctgcacaacc actacaccca gaagtccctg tctctgagcc tgggcaagtt ctgggctctg    1500
gtggtggtgg ctggcgtgct gttctgttac ggcctgctcg tgaccgtggc actgtgtgtg    1560
atctggaccc tgaagtggat cagaaagaag ttcccccaca tcttcaagca gcccttcaag    1620
aaaaccaccg gcgctgctca ggaagaggac gcttgcagct gtagatgccc ccaggaagaa    1680
gagggcggag ggggcggata cgagctgaga gccaagttct ccagaagcgc cgagacagcc    1740
gccaacctgc aggaccccaa ccagctctac aatgagctca atctagggcg aagagaggaa    1800
tatgacgtct tggagaagaa gcgggctcgg gatccagaga tgggaggcaa acagcagagg    1860
aggaggaacc cccaggaagg cgtatacaat gcactgcaga aagacaagat ggcagaagcc    1920
tacagtgaga tcggcacaaa aggcgagagg cggagaggca aggggcacga tggcctttac    1980
cagggtctca gcactgccac caaggacacc tatgatgccc tgcatatgca gaccctggcc    2040
cctcgcggca gcggcgccac caacttcagc ctgctgaagc aggccggcga cgtggaggaa    2100
aaccctggcc ccatgccatc tcctctccct gtctccttcc tcctctttct taccttagta    2160
ggaggcaggc cccagaagtc cttactggtg gaggtagaag agggaggcaa tgttgtgctg    2220
ccatgcctcc cggactcctc acctgtctct tctgagaagc tggcttggta tcgaggtaac    2280
cagtcaacac ccttcctgga gctgagcccc gggtcccctg gcctgggatt gcacgtgggg    2340
tccctgggca tcttgctagt gattgtcaat gtctcagacc atatgggggg cttctacctg    2400
tgccagaaga ggcccccttt caaggacatc tggcagcctg cctggacagt gaacgtggag    2460
gatagtgggg agatgttccg gtggaatgct tcagacgtca gggacctgga ctgtgaccta    2520
aggaacaggt cctctgggag ccacaggtcc acttctggtt cccagctgta tgtgtgggct    2580
aaagaccatc ctaaggtctg gggaacaaag cctgtatgtg cccctcgggg gagcagtttg    2640
aatcagagtc taatcaacca agatctcact gtggcacccg gctccacact ttggctgtcc    2700
tgtggggtac cccctgtccc agtggccaaa ggctccatct cctggaccca tgtgcatcct    2760
aggagaccta atgtttcact actgagccta agccttgggg gagagcaccc ggtcagagag    2820
atgtgggttt gggggtctct tctgcttctg ccccaagcca cagctttaga tgaaggcacc    2880
tattattgtc tccgaggaaa cctgaccatc gagaggcacg tgaaggtcat tgcaaggtca    2940
gtgtggctct ggctgttgag aactggtgga tggatagtcc cagtggtgac tttagtatat    3000
gtcatcttct gtatggtttc tctggtggct tttctctatt gtcaaagagc ctttatcctg    3060
agaaggaaaa ggtga                                                     3075

<210> 83
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence -TRAC_SGRNA_PLENTI_F1

<400> 83
caccggagaa tcaaaatcgg tgaat                                            25

<210> 84
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - TRAC_SGRNA_PLENTI_R1

<400> 84
aaacattcac cgattttgat tctcc                                            25

<210> 85
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - PD1_SGRNA_F1

<400> 85
caccgcagtt gtgtgacacg gaag                                             24

<210> 86
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - PD1_SGRNA_R1

<400> 86
aaaccttccg tgtcacacaa ctgc                                             24

<210> 87
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CTLA4_SGRNA_F1

<400> 87
caccggcaaa ggtgagtgag acttt                                            25

<210> 88
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CTLA4_SGRNA_R1

<400> 88
aaacaaagtc tcactcacct ttgcc                                            25

<210> 89
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - LAG3_SGRNA_F1

<400> 89
caccggtttc tgcagccgct ttggg                                            25

<210> 90
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - LAG3_SGRNA_R2

<400> 90
aaaccccaaa gcggctgcag aaacc                                            25

<210> 91
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - S2 PROTEOLYTIC CLEAVAGE
      SITE-CONTAINING SEQUENCE

<400> 91
Lys Ile Glu Ala Val Ser Lys Glu
 1               5

<210> 92
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - S2 PROTEOLYTIC CLEAVAGE
      SITE-CONTAINING SEQUENCE

<400> 92
Lys Ile Glu Ala Val Gln Ser Glu
 1               5

<210> 93
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - GAMMA-SECRETASE CLEAVAGE
      SITE-CONTAINING SEQUENCE

<400> 93
Val Gly Cys Gly Val Leu Leu Ser
 1               5

<210> 94
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - GAMMA-SECRETASE CLEAVAGE
      SITE-CONTAINING SEQUENCE

<400> 94
Gly Cys Gly Val Leu Leu Ser
 1               5

<210> 95
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - furin-like protease cleavage
      site

<220>
<221> VARIANT        
<222> 2
<223> Xaa = any amino acid

<220>
<221> VARIANT        
<222> 3
<223> Xaa = Arg or Lys

<400> 95
Arg Xaa Xaa Arg
 1

<210> 96
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - FURIN-LIKE PROTEASE CLEAVAGE
      SITE-CONTAINING SEQUENCE

<400> 96
Gly Arg Arg Arg Arg Glu Leu Asp Pro Met
 1               5                  10

<210> 97
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - FURIN-LIKE PROTEASE CLEAVAGE
      SITE

<400> 97
Arg Gln Arg Arg Glu Leu Asp Pro Met
 1               5

<210> 98
<211> 1614
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ANTI-CD19 TRIGGER POLYPEPTIDE

<400> 98
atcctggact acagcttcac aggtggcgct gggcgcgaca ttcccccacc gcagattgag      60
gaggcctgtg agctgcctga gtgccaggtg gatgcaggca ataaggtctg caacctgcag     120
tgtaataatc acgcatgtgg ctgggatggt ggcgactgct ccctcaactt caatgacccc     180
tggaagaact gcacgcagtc tctacagtgc tggaagtatt ttagcgacgg ccactgtgac     240
agccagtgca actcggccgg ctgcctcttt gatggcttcg actgccagct caccgaggga     300
cagtgcaacc ccctgtatga ccagtactgc aaggaccact tcagtgatgg ccactgcgac     360
cagggctgta acagtgccga atgtgagtgg gatggcctag actgtgctga gcatgtaccc     420
gagcggctgg cagccggcac cctggtgctg gtggtgctgc ttccacccga ccagctacgg     480
aacaactcct tccactttct gcgggagctc agccacgtgc tgcacaccaa cgtggtcttc     540
aagcgtgatg cgcaaggcca gcagatgatc ttcccgtact atggccacga ggaagagctg     600
cgcaagcacc caatcaagcg ctctacagtg ggttgggcca cctcttcact gcttcctggt     660
accagtggtg ggcgccagcg cagggagctg gaccccatgg acatccgtgg ctccattgtc     720
tacctggaga tcgacaaccg gcaatgtgtg cagtcatcct cgcagtgctt ccagagtgcc     780
accgatgtgg ctgccttcct aggtgctctt gcgtcacttg gcagcctcaa tattccttac     840
aagattgagg ccgtgaagag tgagccggtg gagcctccgc tgccctcgca gctgcacctc     900
atgtacgtgg cagcggccgc cttcgtgctc ctgttctttg tgggctgtgg ggtgctgctg     960
tcccgcaagc gccggcggat gaagctgctg agcagcatcg agcaggcctg tgacatctgc    1020
cggctgaaga aactgaagtg cagcaaagaa aagcccaagt gcgccaagtg cctgaagaac    1080
aactgggagt gccggtacag ccccaagacc aagagaagcc ccctgaccag agcccacctg    1140
accgaggtgg aaagccggct ggaaagactg gaacagctgt ttctgctgat cttcccacgc    1200
gaggacctgg acatgatcct gaagatggac agcctgcagg acatcaaggc cctgctgacc    1260
ggcctgttcg tgcaggacaa cgtgaacaag gacgccgtga ccgacagact ggccagcgtg    1320
gaaaccgaca tgcccctgac cctgcggcag cacagaatca gcgccaccag cagcagcgag    1380
gaaagcagca acaagggcca gcggcagctg acagtgtctg ctgctgcagg cggaagcgga    1440
ggctctggcg gatctgatgc cctggacgac ttcgacctgg atatgctggg cagcgacgcc    1500
ctggatgatt ttgatctgga catgctggga tctgacgctc tggacgattt cgatctcgac    1560
atgttgggat cagatgcact ggatgacttt gacctggaca tgctcggatc atga          1614

<210> 99
<211> 2454
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - EPCAM GAL4VP64 TRIGGER
      POLYPEPTIDE

<400> 99
atggctagtc ctctgaccag attcctgagc ctgaacctgc tgctgctggg cgagtctatc      60
atcctcggat ctggcgaggc tgagcagaag ctgatctccg aagaggacct ggaagtgcag     120
ctggctgaaa gtggcggagg actggttcag cctggcagat ccatgaagct gagctgtgcc     180
gccagcggct tcaccttcag caacttccct atggcctggg tccgacaggc ccctacaaaa     240
ggactggaat gggtcgccac catcagcaca tctggcggca gcacctacta cagagacagc     300
gtgaagggca gattcaccat ctccagagac aacgccaaga gcaccctgta cctgcagatg     360
aacagcctga gaagcgagga caccgctacc tactactgca ccagaacact gtatatcctg     420
cgggtgttct acttcgacta ctggggccag ggcgtgatgg tcacagtttc tagcggaggc     480
ggaggttctg gcggcggagg atcaggtggt ggcggatctg atatccagat gacacagagc     540
cctgccagcc tgtctgcttc tctgggagag acagtgtcca tcgagtgtct ggccagcgag     600
ggcatctcta acgacctggc ctggtatcag cagaagtccg gcaagtctcc ccagctgctg     660
atctacgcca caagcagact gcaggacggc gtgccatcta gattcagcgg ctctggcagc     720
ggcaccagat acagcctgaa gatctctggc atgcagcccg aggacgaggc cgactacttt     780
tgccagcaga gctacaagta cccctggacc tttggcggag gcaccaagct ggaactgaaa     840
atcctggact acagcttcac aggtggcgct gggcgcgaca ttcccccacc gcagattgag     900
gaggcctgtg agctgcctga gtgccaggtg gatgcaggca ataaggtctg caacctgcag     960
tgtaataatc acgcatgtgg ctgggatggt ggcgactgct ccctcaactt caatgacccc    1020
tggaagaact gcacgcagtc tctacagtgc tggaagtatt ttagcgacgg ccactgtgac    1080
agccagtgca actcggccgg ctgcctcttt gatggcttcg actgccagct caccgaggga    1140
cagtgcaacc ccctgtatga ccagtactgc aaggaccact tcagtgatgg ccactgcgac    1200
cagggctgta acagtgccga atgtgagtgg gatggcctag actgtgctga gcatgtaccc    1260
gagcggctgg cagccggcac cctggtgctg gtggtgctgc ttccacccga ccagctacgg    1320
aacaactcct tccactttct gcgggagctc agccacgtgc tgcacaccaa cgtggtcttc    1380
aagcgtgatg cgcaaggcca gcagatgatc ttcccgtact atggccacga ggaagagctg    1440
cgcaagcacc caatcaagcg ctctacagtg ggttgggcca cctcttcact gcttcctggt    1500
accagtggtg ggcgccagcg cagggagctg gaccccatgg acatccgtgg ctccattgtc    1560
tacctggaga tcgacaaccg gcaatgtgtg cagtcatcct cgcagtgctt ccagagtgcc    1620
accgatgtgg ctgccttcct aggtgctctt gcgtcacttg gcagcctcaa tattccttac    1680
aagattgagg ccgtgaagag tgagccggtg gagcctccgc tgccctcgca gctgcacctc    1740
atgtacgtgg cagcggccgc cttcgtgctc ctgttctttg tgggctgtgg ggtgctgctg    1800
tcccgcaagc gccggcggat gaagctgctg agcagcatcg agcaggcctg tgacatctgc    1860
cggctgaaga aactgaagtg cagcaaagaa aagcccaagt gcgccaagtg cctgaagaac    1920
aactgggagt gccggtacag ccccaagacc aagagaagcc ccctgaccag agcccacctg    1980
accgaggtgg aaagccggct ggaaagactg gaacagctgt ttctgctgat cttcccacgc    2040
gaggacctgg acatgatcct gaagatggac agcctgcagg acatcaaggc cctgctgacc    2100
ggcctgttcg tgcaggacaa cgtgaacaag gacgccgtga ccgacagact ggccagcgtg    2160
gaaaccgaca tgcccctgac cctgcggcag cacagaatca gcgccaccag cagcagcgag    2220
gaaagcagca acaagggcca gcggcagctg acagtgtctg ctgctgcagg cggaagcgga    2280
ggctctggcg gatctgatgc cctggacgac ttcgacctgg atatgctggg cagcgacgcc    2340
ctggatgatt ttgatctgga catgctggga tctgacgctc tggacgattt cgatctcgac    2400
atgttgggat cagatgcact ggatgacttt gacctggaca tgctcggatc atga          2454

<210> 100
<211> 5339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - UAS INDUCIBLE ROR1 CAR WITH
      TCD19 AND BFP

<400> 100
ggagcactgt cctccgaacg tcggagcact gtcctccgaa cgtcggagca ctgtcctccg      60
aacgtcggag cactgtcctc cgaacggagc atgtcctccg aacgtcggag cactgtcctc     120
cgaacgacta gttaggcgtg tacggtggga ggcctatata agcagagctc gtttagtgaa     180
ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa gacaccggga     240
ccgatccagc ctctcgacat tcgttggatc cggcggccgc catggctagt cctctgacca     300
gattcctgag cctgaacctg ctgctgctgg gcgagagcat catcctggga tctggcgagg     360
cccagagcgt gaaagagtct gagggcgacc tcgtgacccc tgccggaaac ctgaccctga     420
cctgtacagc cagcggcagc gacatcaacg actaccccat cagctgggtg cgacaggctc     480
ctggcaaggg cctggaatgg atcggcttca tcaacagcgg cggcagcact tggtacgcct     540
cttgggtcaa gggcagattc accatcagca gaaccagcac caccgtggac ctgaagatga     600
ccagcctgac caccgacgac accgccacct acttttgcgc cagaggctac agcacctact     660
acggcgactt caacatctgg ggccctggca ccctcgtgac aatctcttct ggcggcggag     720
gaagcggagg cggaggatct gggggaggcg gatctgagct cgtgatgacc cagaccccta     780
gcagcacatc tggcgctgtg ggcggcaccg tgaccatcaa ctgtcaggcc agccagagca     840
tcgacagcaa cctggcctgg ttccagcaga agcctggcca gcctcctacc ctgctgatct     900
acagagccag caatctggcc agcggcgtgc ccagcagatt cagcggctct agaagcggca     960
ccgagtacac cctgaccatc tccggcgtgc agagagagga cgccgctacc tactactgtc    1020
tgggcggcgt gggcaacgtg tcctacagga catctttcgg cggaggcacc gaggtggtcg    1080
tgaaagaatc taagtacgga ccgccctgcc ccccctgtcc tgctccaccg gtggctggcc    1140
ctagcgtgtt cctgttcccc ccaaagccca aggacaccct gatgatctcc aggacccccg    1200
aagtgacctg cgtggtggtg gatgtgtccc aggaagatcc cgaggtgcag ttcaattggt    1260
acgtggacgg cgtggaagtg cacaacgcca agaccaagcc cagagaggaa cagttccaga    1320
gcacctacag agtggtgtcc gtgctgaccg tgctgcacca ggattggctg aacggcaaag    1380
agtacaagtg caaggtgtcc aacaagggac tgcccagctc catcgaaaag acaatcagca    1440
aggccaaggg acagcctcgc gagccccagg tgtacacact gcctccaagc caggaagaga    1500
tgaccaagaa ccaggtgtcc ctgacatgcc tcgtgaaggg cttctacccc tccgatatcg    1560
ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc cctcccgtgc    1620
tggactccga cggctcattc ttcctgtact ccagactgac cgtggacaag agcagatggc    1680
aggaaggcaa tgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac cactacaccc    1740
agaagtccct gtctctgagc ctgggcaagt tctgggctct ggtggtggtg gctggcgtgc    1800
tgttctgtta cggcctgctc gtgaccgtgg cactgtgtgt gatctggacc ctgaagtgga    1860
tcagaaagaa gttcccccac atcttcaagc agcccttcaa gaaaaccacc ggcgctgctc    1920
aggaagagga cgcttgcagc tgtagatgcc cccaggaaga agagggcgga gggggcggat    1980
acgagctgag agccaagttc tccagaagcg ccgagacagc cgccaacctg caggacccca    2040
accagctcta caatgagctc aatctagggc gaagagagga atatgacgtc ttggagaaga    2100
agcgggctcg ggatccagag atgggaggca aacagcagag gaggaggaac ccccaggaag    2160
gcgtatacaa tgcactgcag aaagacaaga tggcagaagc ctacagtgag atcggcacaa    2220
aaggcgagag gcggagaggc aaggggcacg atggccttta ccagggtctc agcactgcca    2280
ccaaggacac ctatgatgcc ctgcatatgc agaccctggc ccctcgcggc agcggcgcca    2340
ccaacttcag cctgctgaag caggccggcg acgtggagga aaaccctggc cccatgccat    2400
ctcctctccc tgtctccttc ctcctctttc ttaccttagt aggaggcagg ccccagaagt    2460
ccttactggt ggaggtagaa gagggaggca atgttgtgct gccatgcctc ccggactcct    2520
cacctgtctc ttctgagaag ctggcttggt atcgaggtaa ccagtcaaca cccttcctgg    2580
agctgagccc cgggtcccct ggcctgggat tgcacgtggg gtccctgggc atcttgctag    2640
tgattgtcaa tgtctcagac catatggggg gcttctacct gtgccagaag aggccccctt    2700
tcaaggacat ctggcagcct gcctggacag tgaacgtgga ggatagtggg gagatgttcc    2760
ggtggaatgc ttcagacgtc agggacctgg actgtgacct aaggaacagg tcctctggga    2820
gccacaggtc cacttctggt tcccagctgt atgtgtgggc taaagaccat cctaaggtct    2880
ggggaacaaa gcctgtatgt gcccctcggg ggagcagttt gaatcagagt ctaatcaacc    2940
aagatctcac tgtggcaccc ggctccacac tttggctgtc ctgtggggta ccccctgtcc    3000
cagtggccaa aggctccatc tcctggaccc atgtgcatcc taggagacct aatgtttcac    3060
tactgagcct aagccttggg ggagagcacc cggtcagaga gatgtgggtt tgggggtctc    3120
ttctgcttct gccccaagcc acagctttag atgaaggcac ctattattgt ctccgaggaa    3180
acctgaccat cgagaggcac gtgaaggtca ttgcaaggtc agtgtggctc tggctgttga    3240
gaactggtgg atggatagtc ccagtggtga ctttagtata tgtcatcttc tgtatggttt    3300
ctctggtggc ttttctctat tgtcaaagag cctttatcct gagaaggaaa aggtgactcg    3360
aggggatccg gccgcaactc ccacctgcaa catgcgtgac tgactgaggc cgcgactcta    3420
gagtcgacct gcacgaggtt aacgaattct accgggtagg ggaggcgctt ttcccaaggc    3480
agtctggagc atgcgcttta gcagccccgc tgggcacttg gcgctacaca agtggcctct    3540
ggcctcgcac acattccaca tccaccggta ggcgccaacc ggctccgttc tttggtggcc    3600
ccttcgcgcc accttctact cctcccctag tcaggaagtt cccccccgcc ccgcagctcg    3660
cgtcgtgcag gacgtgacaa atggaagtag cacgtctcac tagtctcgtg cagatggaca    3720
gcaccgctga gcaatggaag cgggtaggcc tttggggcag cggccaatag cagctttgct    3780
ccttcgcttt ctgggctcag aggctgggaa ggggtgggtc cgggggcggg ctcaggggcg    3840
gggcgggcgc ccgaaggtcc tccggaggcc cggcattctg cacgcttcaa aagcgcacgt    3900
ctgccgcgct gttctcctct tcctcatctc cgggcctttc gacctgcagc ccaagcttac    3960
catgagcgag ctgattaagg agaacatgca catgaagctg tacatggagg gcaccgtgga    4020
caaccatcac ttcaagtgca catccgaggg cgaaggcaag ccctacgagg gcacccagac    4080
catgagaatc aaggtggtcg agggcggccc tctccccttc gccttcgaca tcctggctac    4140
tagcttcctc tacggcagca agaccttcat caaccacacc cagggcatcc ccgacttctt    4200
caagcagtcc ttccctgagg gcttcacatg ggagagagtc accacatacg aagacggggg    4260
cgtgctgacc gctacccagg acaccagcct ccaggacggc tgcctcatct acaacgtcaa    4320
gatcagaggg gtgaacttca catccaacgg ccctgtgatg cagaagaaaa cactcggctg    4380
ggaggccttc accgagacgc tgtaccccgc tgacggcggc ctggaaggca gaaacgacat    4440
ggccctgaag ctcgtgggcg ggagccatct gatcgcaaac atcaagacca catatagatc    4500
caagaaaccc gctaagaacc tcaagatgcc tggcgtctac tatgtggact acagactgga    4560
aagaatcaag gaggccaaca acgagaccta cgtcgagcag cacgaggtgg cagtggccag    4620
atactgcgac ctccctagca aactggggca caagcttaat taatgcaggc atgcaagctt    4680
gatatcaagc ttatcgataa tcaacctctg gattacaaaa tttgtgaaag attgactggt    4740
attcttaact atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat    4800
catgctattg cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg    4860
tctctttatg aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt    4920
gctgacgcaa cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact    4980
ttcgctttcc ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc    5040
tggacagggg ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaaatcatcg    5100
tcctttcctt ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc    5160
tacgtccctt cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg    5220
cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc    5280
tccccgcatc gataccgtcg acctcgaggg aattaattcg agctcggtac ctttaagac     5339



<210> 101
<211> 682
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - ROR1 CAR [MCD8 LEADER
      SEQUENCE - CD3Z

<400> 101
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu
 1               5                  10                  15
Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Gln Ser Val Lys Glu
            20                  25                  30
Ser Glu Gly Asp Leu Val Thr Pro Ala Gly Asn Leu Thr Leu Thr Cys
        35                  40                  45
Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr Pro Ile Ser Trp Val Arg
    50                  55                  60
Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Phe Ile Asn Ser Gly
65                  70                  75                  80
Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly Arg Phe Thr Ile Ser
                85                  90                  95
Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr Ser Leu Thr Thr Asp
            100                 105                 110
Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Gly
        115                 120                 125
Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser Ser Gly
    130                 135                 140
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu
145                 150                 155                 160
Val Met Thr Gln Thr Pro Ser Ser Thr Ser Gly Ala Val Gly Gly Thr
                165                 170                 175
Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn Leu Ala
            180                 185                 190
Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Thr Leu Leu Ile Tyr Arg
        195                 200                 205
Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg
    210                 215                 220
Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Arg Glu Asp
225                 230                 235                 240
Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Asn Val Ser Tyr Arg
                245                 250                 255
Thr Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys Glu Ser Lys Tyr
            260                 265                 270
Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser
        275                 280                 285
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    290                 295                 300
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro
305                 310                 315                 320
Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                325                 330                 335
Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val
            340                 345                 350
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        355                 360                 365
Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr
    370                 375                 380
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
385                 390                 395                 400
Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
                405                 410                 415
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            420                 425                 430
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        435                 440                 445
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser
    450                 455                 460
Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
465                 470                 475                 480
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
                485                 490                 495
Phe Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu
            500                 505                 510
Leu Val Thr Val Ala Leu Cys Val Ile Trp Thr Leu Lys Trp Ile Arg
        515                 520                 525
Lys Lys Phe Pro His Ile Phe Lys Gln Pro Phe Lys Lys Thr Thr Gly
    530                 535                 540
Ala Ala Gln Glu Glu Asp Ala Cys Ser Cys Arg Cys Pro Gln Glu Glu
545                 550                 555                 560
Glu Gly Gly Gly Gly Gly Tyr Glu Leu Arg Ala Lys Phe Ser Arg Ser
                565                 570                 575
Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu
            580                 585                 590
Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg
        595                 600                 605
Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro
    610                 615                 620
Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala
625                 630                 635                 640
Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His
                645                 650                 655
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp
            660                 665                 670
Ala Leu His Met Gln Thr Leu Ala Pro Arg
        675                 680

<210> 102
<211> 320
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - TCD19 TRANSDUCTION MARKER

<400> 102
Met Pro Ser Pro Leu Pro Val Ser Phe Leu Leu Phe Leu Thr Leu Val
 1               5                  10                  15
Gly Gly Arg Pro Gln Lys Ser Leu Leu Val Glu Val Glu Glu Gly Gly
            20                  25                  30
Asn Val Val Leu Pro Cys Leu Pro Asp Ser Ser Pro Val Ser Ser Glu
        35                  40                  45
Lys Leu Ala Trp Tyr Arg Gly Asn Gln Ser Thr Pro Phe Leu Glu Leu
    50                  55                  60
Ser Pro Gly Ser Pro Gly Leu Gly Leu His Val Gly Ser Leu Gly Ile
65                  70                  75                  80
Leu Leu Val Ile Val Asn Val Ser Asp His Met Gly Gly Phe Tyr Leu
                85                  90                  95
Cys Gln Lys Arg Pro Pro Phe Lys Asp Ile Trp Gln Pro Ala Trp Thr
            100                 105                 110
Val Asn Val Glu Asp Ser Gly Glu Met Phe Arg Trp Asn Ala Ser Asp
        115                 120                 125
Val Arg Asp Leu Asp Cys Asp Leu Arg Asn Arg Ser Ser Gly Ser His
    130                 135                 140
Arg Ser Thr Ser Gly Ser Gln Leu Tyr Val Trp Ala Lys Asp His Pro
145                 150                 155                 160
Lys Val Trp Gly Thr Lys Pro Val Cys Ala Pro Arg Gly Ser Ser Leu
                165                 170                 175
Asn Gln Ser Leu Ile Asn Gln Asp Leu Thr Val Ala Pro Gly Ser Thr
            180                 185                 190
Leu Trp Leu Ser Cys Gly Val Pro Pro Val Pro Val Ala Lys Gly Ser
        195                 200                 205
Ile Ser Trp Thr His Val His Pro Arg Arg Pro Asn Val Ser Leu Leu
    210                 215                 220
Ser Leu Ser Leu Gly Gly Glu His Pro Val Arg Glu Met Trp Val Trp
225                 230                 235                 240
Gly Ser Leu Leu Leu Leu Pro Gln Ala Thr Ala Leu Asp Glu Gly Thr
                245                 250                 255
Tyr Tyr Cys Leu Arg Gly Asn Leu Thr Ile Glu Arg His Val Lys Val
            260                 265                 270
Ile Ala Arg Ser Val Trp Leu Trp Leu Leu Arg Thr Gly Gly Trp Ile
        275                 280                 285
Val Pro Val Val Thr Leu Val Tyr Val Ile Phe Cys Met Val Ser Leu
    290                 295                 300
Val Ala Phe Leu Tyr Cys Gln Arg Ala Phe Ile Leu Arg Arg Lys Arg
305                 310                 315                 320

<210> 103
<211> 233
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - BLUE FLUORESCENT PROTEIN

<400> 103
Met Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu
 1               5                  10                  15
Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly
            20                  25                  30
Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly
        35                  40                  45
Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr
    50                  55                  60
Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe
65                  70                  75                  80
Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr
                85                  90                  95
Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp
            100                 105                 110
Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser
        115                 120                 125
Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr
    130                 135                 140
Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met
145                 150                 155                 160
Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr
                165                 170                 175
Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val
            180                 185                 190
Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu
        195                 200                 205
Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu
    210                 215                 220
Pro Ser Lys Leu Gly His Lys Leu Asn
225                 230

<210> 104
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - BRCA69D VH

<400> 104
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
 1               5                  10                  15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30
Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45
Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe
    50                  55                  60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Arg Gly Ile Pro Arg Leu Trp Tyr Phe Asp Val Trp Gly Ala
            100                 105                 110
Gly Thr Thr Val Thr Val Ser Ser
        115                 120

<210> 105
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - BRCA69D HCDR1

<400> 105
Ser Tyr Trp Met Gln
 1               5

<210> 106
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - BRCA69D HCDR2

<400> 106
Thr Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe Lys
 1               5                  10                  15
Gly


<210> 107
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - (BRCA69D HCDR3

<400> 107
Arg Gly Ile Pro Arg Leu Trp Tyr Phe Asp Val
 1               5                  10

<210> 108
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - BRCA69D VL

<400> 108
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
            20                  25                  30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Asp Asn Leu Glu Gln
65                  70                  75                  80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Pro
                85                  90                  95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105

<210> 109
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - BRCA69D LCDR1

<400> 109
Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn
 1               5                  10

<210> 110
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - BRCA69D LCDR2

<400> 110
Tyr Thr Ser Arg Leu His Ser
 1               5

<210> 111
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - BRCA69D LCDR3

<400> 111
Gln Gln Gly Asn Thr Leu Pro Pro Thr
 1               5

<210> 112
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - G8.8 VH

<400> 112
Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe
            20                  25                  30
Pro Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Thr Ile Ser Thr Ser Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95
Thr Arg Thr Leu Tyr Ile Leu Arg Val Phe Tyr Phe Asp Tyr Trp Gly
            100                 105                 110
Gln Gly Val Met Val Thr Val Ser Ser
        115                 120

<210> 113
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - G8.8 VL

<400> 113
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15
Glu Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Gly Ile Ser Asn Asp
            20                  25                  30
Leu Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45
Tyr Ala Thr Ser Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Arg Tyr Ser Leu Lys Ile Ser Gly Met Gln Pro
65                  70                  75                  80
Glu Asp Glu Ala Asp Tyr Phe Cys Gln Gln Ser Tyr Lys Tyr Pro Trp
                85                  90                  95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys
            100                 105
