                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior 
       University
       Hunter, Sean A
       Cochran, Jennifer
 
<120>  SOLUBLE POLYPEPTIDES AND METHODS OF USING SAME FOR INHIBITING 
       LEUKEMIA INHIBITORY FACTOR ACTIVITY

<130>  STAN-1475WO

<150>  US62/701,399
<151>  2018-07-20

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  789
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Lys Lys Gly Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu 
1               5                   10                  15      


Gln Val Trp Asn Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly 
            20                  25                  30          


Thr Asp Tyr Glu Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln 
        35                  40                  45              


Leu Glu Lys Thr Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr 
    50                  55                  60                  


Glu Ile Thr Ile Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys 
65                  70                  75                  80  


Phe Thr Leu Asn Glu Gln Asn Val Ser Leu Ile Pro Asp Thr Pro Glu 
                85                  90                  95      


Ile Leu Asn Leu Ser Ala Asp Phe Ser Thr Ser Thr Leu Tyr Leu Lys 
            100                 105                 110         


Trp Asn Asp Arg Gly Ser Val Phe Pro His Arg Ser Asn Val Ile Trp 
        115                 120                 125             


Glu Ile Lys Val Leu Arg Lys Glu Ser Met Glu Leu Val Lys Leu Val 
    130                 135                 140                 


Thr His Asn Thr Thr Leu Asn Gly Lys Asp Thr Leu His His Trp Ser 
145                 150                 155                 160 


Trp Ala Ser Asp Met Pro Leu Glu Cys Ala Ile His Phe Val Glu Ile 
                165                 170                 175     


Arg Cys Tyr Ile Asp Asn Leu His Phe Ser Gly Leu Glu Glu Trp Ser 
            180                 185                 190         


Asp Trp Ser Pro Val Lys Asn Ile Ser Trp Ile Pro Asp Ser Gln Thr 
        195                 200                 205             


Lys Val Phe Pro Gln Asp Lys Val Ile Leu Val Gly Ser Asp Ile Thr 
    210                 215                 220                 


Phe Cys Cys Val Ser Gln Glu Lys Val Leu Ser Ala Leu Ile Gly His 
225                 230                 235                 240 


Thr Asn Cys Pro Leu Ile His Leu Asp Gly Glu Asn Val Ala Ile Lys 
                245                 250                 255     


Ile Arg Asn Ile Ser Val Ser Ala Ser Ser Gly Thr Asn Val Val Phe 
            260                 265                 270         


Thr Thr Glu Asp Asn Ile Phe Gly Thr Val Ile Phe Ala Gly Tyr Pro 
        275                 280                 285             


Pro Asp Thr Pro Gln Gln Leu Asn Cys Glu Thr His Asp Leu Lys Glu 
    290                 295                 300                 


Ile Ile Cys Ser Trp Asn Pro Gly Arg Val Thr Ala Leu Val Gly Pro 
305                 310                 315                 320 


Arg Ala Thr Ser Tyr Thr Leu Val Glu Ser Phe Ser Gly Lys Tyr Val 
                325                 330                 335     


Arg Leu Lys Arg Ala Glu Ala Pro Thr Asn Glu Ser Tyr Gln Leu Leu 
            340                 345                 350         


Phe Gln Met Leu Pro Asn Gln Glu Ile Tyr Asn Phe Thr Leu Asn Ala 
        355                 360                 365             


His Asn Pro Leu Gly Arg Ser Gln Ser Thr Ile Leu Val Asn Ile Thr 
    370                 375                 380                 


Glu Lys Val Tyr Pro His Thr Pro Thr Ser Phe Lys Val Lys Asp Ile 
385                 390                 395                 400 


Asn Ser Thr Ala Val Lys Leu Ser Trp His Leu Pro Gly Asn Phe Ala 
                405                 410                 415     


Lys Ile Asn Phe Leu Cys Glu Ile Glu Ile Lys Lys Ser Asn Ser Val 
            420                 425                 430         


Gln Glu Gln Arg Asn Val Thr Ile Lys Gly Val Glu Asn Ser Ser Tyr 
        435                 440                 445             


Leu Val Ala Leu Asp Lys Leu Asn Pro Tyr Thr Leu Tyr Thr Phe Arg 
    450                 455                 460                 


Ile Arg Cys Ser Thr Glu Thr Phe Trp Lys Trp Ser Lys Trp Ser Asn 
465                 470                 475                 480 


Lys Lys Gln His Leu Thr Thr Glu Ala Ser Pro Ser Lys Gly Pro Asp 
                485                 490                 495     


Thr Trp Arg Glu Trp Ser Ser Asp Gly Lys Asn Leu Ile Ile Tyr Trp 
            500                 505                 510         


Lys Pro Leu Pro Ile Asn Glu Ala Asn Gly Lys Ile Leu Ser Tyr Asn 
        515                 520                 525             


Val Ser Cys Ser Ser Asp Glu Glu Thr Gln Ser Leu Ser Glu Ile Pro 
    530                 535                 540                 


Asp Pro Gln His Lys Ala Glu Ile Arg Leu Asp Lys Asn Asp Tyr Ile 
545                 550                 555                 560 


Ile Ser Val Val Ala Lys Asn Ser Val Gly Ser Ser Pro Pro Ser Lys 
                565                 570                 575     


Ile Ala Ser Met Glu Ile Pro Asn Asp Asp Leu Lys Ile Glu Gln Val 
            580                 585                 590         


Val Gly Met Gly Lys Gly Ile Leu Leu Thr Trp His Tyr Asp Pro Asn 
        595                 600                 605             


Met Thr Cys Asp Tyr Val Ile Lys Trp Cys Asn Ser Ser Arg Ser Glu 
    610                 615                 620                 


Pro Cys Leu Met Asp Trp Arg Lys Val Pro Ser Asn Ser Thr Glu Thr 
625                 630                 635                 640 


Val Ile Glu Ser Asp Glu Phe Arg Pro Gly Ile Arg Tyr Asn Phe Phe 
                645                 650                 655     


Leu Tyr Gly Cys Arg Asn Gln Gly Tyr Gln Leu Leu Arg Ser Met Ile 
            660                 665                 670         


Gly Tyr Ile Glu Glu Leu Ala Pro Ile Val Ala Pro Asn Phe Thr Val 
        675                 680                 685             


Glu Asp Thr Ser Ala Asp Ser Ile Leu Val Lys Trp Glu Asp Ile Pro 
    690                 695                 700                 


Val Glu Glu Leu Arg Gly Phe Leu Arg Gly Tyr Leu Phe Tyr Phe Gly 
705                 710                 715                 720 


Lys Gly Glu Arg Asp Thr Ser Lys Met Arg Val Leu Glu Ser Gly Arg 
                725                 730                 735     


Ser Asp Ile Lys Val Lys Asn Ile Thr Asp Ile Ser Gln Lys Thr Leu 
            740                 745                 750         


Arg Ile Ala Asp Leu Gln Gly Lys Thr Ser Tyr His Leu Val Leu Arg 
        755                 760                 765             


Ala Tyr Thr Asp Gly Gly Val Gly Pro Glu Lys Ser Met Tyr Val Val 
    770                 775                 780                 


Thr Lys Glu Asn Ser 
785                 


<210>  2
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  2

Gln Lys Lys Gly Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu 
1               5                   10                  15      


Gln Val Trp Asn Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly 
            20                  25                  30          


Thr Asp Tyr Glu Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln 
        35                  40                  45              


Leu Glu Lys Thr Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr 
    50                  55                  60                  


Glu Ile Thr Ile Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys 
65                  70                  75                  80  


Phe Thr Leu Asn Glu Gln Asn Val Ser Leu Ile Pro Asp Thr Pro Glu 
                85                  90                  95      


Ile Leu Asn Leu Ser Ala Asp Phe Ser Thr Ser Thr Leu Tyr Leu Lys 
            100                 105                 110         


Trp Asn Asp Arg Gly Ser Val Phe Pro His Arg Ser Asn Val Ile Trp 
        115                 120                 125             


Glu Ile Lys Val Leu Arg Lys Glu Ser Met Glu Leu Val Lys Leu Val 
    130                 135                 140                 


Thr His Asn Thr Thr Leu Asn Gly Lys Asp Thr Leu His His Trp Ser 
145                 150                 155                 160 


Trp Ala Ser Asp Met Pro Leu Glu Cys Ala Ile His Phe Val Glu Ile 
                165                 170                 175     


Arg Cys Tyr Ile Asp Asn Leu His Phe Ser Gly Leu Glu Glu Trp Ser 
            180                 185                 190         


Asp Trp Ser Pro Val Lys Asn Ile Ser Trp Ile Pro Asp Ser Gln Thr 
        195                 200                 205             


Lys Val Phe Pro Gln Asp Lys Val Ile Leu Val Gly Ser Asp Ile Thr 
    210                 215                 220                 


Phe Cys Cys Val Ser Gln Glu Lys Val Leu Ser Ala Leu Ile Gly His 
225                 230                 235                 240 


Thr Asn Cys Pro Leu Ile His Leu Asp Gly Glu Asn Val Ala Ile Lys 
                245                 250                 255     


Ile Arg Asn Ile Ser Val Ser Ala Ser Ser Gly Thr Asn Val Val Phe 
            260                 265                 270         


Thr Thr Glu Asp Asn Ile Phe Gly Thr Val Ile Phe Ala Gly Tyr Pro 
        275                 280                 285             


Pro Asp Thr Pro Gln Gln Leu Asn Cys Glu Thr His Asp Leu Lys Glu 
    290                 295                 300                 


Ile Ile Cys Ser Trp Asn Pro Gly Arg Val Thr Ala Leu Val Gly Pro 
305                 310                 315                 320 


Arg Ala Thr Ser Tyr Thr Leu Val Glu Ser Phe Ser Gly Lys Tyr Val 
                325                 330                 335     


Arg Leu Lys Arg Ala Glu Ala Pro Thr Asn Glu Ser Tyr Gln Leu Leu 
            340                 345                 350         


Phe Gln Met Leu Pro Asn Gln Glu Ile Tyr Asn Phe Thr Leu Asn Ala 
        355                 360                 365             


His Asn Pro Leu Gly Arg Ser Gln Ser Thr Ile Leu Val Asn Ile Thr 
    370                 375                 380                 


Glu Lys Val Tyr Pro His Thr Pro Thr Ser Phe Lys Val Lys Asp Ile 
385                 390                 395                 400 


Asn Ser Thr Ala Val Lys Leu Ser Trp His Leu Pro Gly Asn Phe Ala 
                405                 410                 415     


Lys Ile Asn Phe Leu Cys Glu Ile Glu Ile Lys Lys Ser Asn Ser Val 
            420                 425                 430         


Gln Glu Gln Arg Asn Val Thr Ile Lys Gly Val Glu Asn Ser Ser Tyr 
        435                 440                 445             


Leu Val Ala Leu Asp Lys Leu Asn Pro Tyr Thr Leu Tyr Thr Phe Arg 
    450                 455                 460                 


Ile Arg Cys Ser Thr Glu Thr Phe Trp Lys Trp Ser Lys Trp Ser Asn 
465                 470                 475                 480 


Lys Lys Gln His Leu Thr Thr Glu Ala Ser 
                485                 490 


<210>  3
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser Pro Glu Ser Pro Val Val 
1               5                   10                  15      


Gln Leu His Ser Asn Phe Thr Ala Val Cys Val Leu Lys Glu Lys Cys 
            20                  25                  30          


Met Asp Tyr Phe His Val Asn Ala Asn Tyr Ile Val Trp Lys Thr Asn 
        35                  40                  45              


His Phe Thr Ile Pro Lys Glu Gln Tyr Thr Ile Ile Asn Arg Thr Ala 
    50                  55                  60                  


Ser Ser Val Thr Phe Thr Asp Ile Ala Ser Leu Asn Ile Gln Leu Thr 
65                  70                  75                  80  


Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu Gln Asn Val Tyr Gly Ile 
                85                  90                  95      


Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys 
            100                 105                 110         


Ile Val Asn Glu Gly Lys Lys Met Arg Cys Glu Trp Asp Arg Gly Arg 
        115                 120                 125             


Glu Thr His Leu Glu Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr 
    130                 135                 140                 


His Lys Phe Ala Asp Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys 
145                 150                 155                 160 


Thr Val Asp Tyr Ser Thr Val Tyr Phe Val Asn Ile Glu Val Trp Val 
                165                 170                 175     


Glu Ala Glu Asn Ala Leu Gly Lys Val Thr Ser Asp His Ile Asn Phe 
            180                 185                 190         


Asp Pro Val Tyr Lys Val Lys Pro Asn Pro Pro His Asn Leu Ser Val 
        195                 200                 205             


Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn 
    210                 215                 220                 


Pro Ser Ile Lys Ser Val Ile Ile Leu Lys Tyr Asn Ile Gln Tyr Arg 
225                 230                 235                 240 


Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala 
                245                 250                 255     


Ser Thr Arg Ser Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu 
            260                 265                 270         


Tyr Val Phe Arg Ile Arg Cys Met Lys Glu Asp Gly Lys Gly Tyr Trp 
        275                 280                 285             


Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile Thr Tyr Glu Asp Arg Pro 
    290                 295                 300                 


Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile Asp Pro Ser His Thr Gln 
305                 310                 315                 320 


Gly Tyr Arg Thr Val Gln Leu Val Trp Lys Thr Leu Pro Pro Phe Glu 
                325                 330                 335     


Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Thr Leu Thr Arg Trp Lys 
            340                 345                 350         


Ser His Leu Gln Asn Tyr Thr Val Asn Ala Thr Lys Leu Thr Val Asn 
        355                 360                 365             


Leu Thr Asn Asp Arg Tyr Val Ala Thr Leu Thr Val Arg Asn Leu Val 
    370                 375                 380                 


Gly Lys Ser Asp Ala Ala Val Leu Thr Ile Pro Ala Cys Asp Phe Gln 
385                 390                 395                 400 


Ala Thr His Pro Val Met Asp Leu Lys Ala Phe Pro Lys Asp Asn Met 
                405                 410                 415     


Leu Trp Val Glu Trp Thr Thr Pro Arg Glu Ser Val Lys Lys Tyr Ile 
            420                 425                 430         


Leu Glu Trp Cys Val Leu Ser Asp Lys Ala Pro Cys Ile Thr Asp Trp 
        435                 440                 445             


Gln Gln Glu Asp Gly Thr Val His Arg Thr Tyr Leu Arg Gly Asn Leu 
    450                 455                 460                 


Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val Thr Pro Val Tyr Ala Asp 
465                 470                 475                 480 


Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala Tyr Leu Lys Gln Ala Pro 
                485                 490                 495     


Pro Ser Lys Gly Pro Thr Val Arg Thr Lys Lys Val Gly Lys Asn Glu 
            500                 505                 510         


Ala Val Leu Glu Trp Asp Gln Leu Pro Val Asp Val Gln Asn Gly Phe 
        515                 520                 525             


Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr Ile Ile Gly Asn Glu Thr 
    530                 535                 540                 


Ala Val Asn Val Asp Ser Ser His Thr Glu Tyr Thr Leu Ser Ser Leu 
545                 550                 555                 560 


Thr Ser Asp Thr Leu Tyr Met Val Arg Met Ala Ala Tyr Thr Asp Glu 
                565                 570                 575     


Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr Pro Lys Phe Ala 
            580                 585                 590         


Gln Gly Glu Ile Glu 
        595         


<210>  4
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  4

Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly 
1               5                   10                  15      


Lys Lys Met Arg Cys Glu Trp Asp Arg Gly Arg Glu Thr His Leu Glu 
            20                  25                  30          


Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp 
        35                  40                  45              


Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser 
    50                  55                  60                  


Thr Val Tyr Phe Val Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala 
65                  70                  75                  80  


Leu Gly Lys Val Thr Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys 
                85                  90                  95      


Val Lys Pro Asn Pro Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu 
            100                 105                 110         


Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser 
        115                 120                 125             


Val Ile Ile Leu Lys Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser 
    130                 135                 140                 


Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser 
145                 150                 155                 160 


Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile 
                165                 170                 175     


Arg Cys Met Lys Glu Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu 
            180                 185                 190         


Glu Ala Ser Gly Ile Thr Tyr Glu Asp 
        195                 200     


<210>  5
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  6
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  6

Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly 
1               5                   10                  15      


Lys Lys Met Arg Cys Glu Trp Asp Arg Gly Arg Glu Thr His Leu Glu 
            20                  25                  30          


Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr His Glu Leu Ala Asp 
        35                  40                  45              


Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser 
    50                  55                  60                  


Thr Val Tyr Phe Val Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala 
65                  70                  75                  80  


Leu Gly Lys Val Thr Ser Asp His Ile Asn Phe Asp Pro Val Asp Lys 
                85                  90                  95      


Val Lys Pro Asn Pro Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu 
            100                 105                 110         


Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser 
        115                 120                 125             


Val Met Ile Leu Lys Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser 
    130                 135                 140                 


Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser 
145                 150                 155                 160 


Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile 
                165                 170                 175     


Arg Cys Met Lys Glu Asp Gly Glu Gly Tyr Trp Ser Asp Trp Ser Glu 
            180                 185                 190         


Glu Ala Ser Gly Ile Thr Tyr Glu Asp Gly Ser Gly Ser Gly Ser Asp 
        195                 200                 205             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    210                 215                 220                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
225                 230                 235                 240 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                245                 250                 255     


Asp Pro Gln Val Lys Phe Asn Trp Tyr Val Asp Gly Val Gln Val His 
            260                 265                 270         


Asn Ala Lys Thr Lys Pro Arg Glu Gln Gln Tyr Asn Ser Thr Tyr Arg 
        275                 280                 285             


Val Val Ser Val Leu Thr Val Leu His Gln Asn Trp Leu Asp Gly Lys 
    290                 295                 300                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
305                 310                 315                 320 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                325                 330                 335     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            340                 345                 350         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        355                 360                 365             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    370                 375                 380                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
385                 390                 395                 400 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                405                 410                 415     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            420                 425                 430         


Gly Lys 
        


<210>  7
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  7

Gln Lys Lys Gly Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu 
1               5                   10                  15      


Gln Val Trp Asn Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly 
            20                  25                  30          


Thr Asp Tyr Glu Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln 
        35                  40                  45              


Leu Glu Lys Thr Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr 
    50                  55                  60                  


Glu Ile Thr Ile Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys 
65                  70                  75                  80  


Phe Thr Leu Asn Glu Gln Asn Val Ser Leu Ile Pro Asp Thr Pro Glu 
                85                  90                  95      


Ile Leu Asn Leu Ser Ala Asp Phe Ser Thr Ser Thr Leu Tyr Leu Lys 
            100                 105                 110         


Trp Asn Asp Arg Gly Ser Val Phe Pro His Arg Ser Asn Val Ile Trp 
        115                 120                 125             


Glu Ile Lys Val Leu Arg Lys Glu Ser Met Glu Leu Val Lys Leu Val 
    130                 135                 140                 


Thr His Asn Thr Thr Leu Asn Gly Lys Asp Thr Leu His His Trp Ser 
145                 150                 155                 160 


Trp Ala Ser Asp Met Pro Leu Glu Cys Ala Ile His Phe Val Glu Ile 
                165                 170                 175     


Arg Cys Tyr Ile Asp Asn Leu His Phe Ser Gly Leu Glu Glu Trp Ser 
            180                 185                 190         


Asp Trp Ser Pro Val Lys Asn Ile Ser Trp Ile Pro Asp Ser Gln Thr 
        195                 200                 205             


Lys Val Phe Pro Gln Asp Lys Val Val Pro Val Gly Ser Asp Ile Thr 
    210                 215                 220                 


Phe Cys Cys Val Ser Gln Glu Lys Val Leu Ser Ala Leu Ile Gly Arg 
225                 230                 235                 240 


Thr Asp Cys Pro Leu Ile His Leu Asp Gly Glu Asn Val Ala Ile Lys 
                245                 250                 255     


Val Arg Asn Val Ser Ala Ser Ala Ser Ser Gly Thr Asn Val Val Phe 
            260                 265                 270         


Ile Thr Glu Asp Asp Ile Phe Gly Thr Val Ile Phe Ala Gly Tyr Pro 
        275                 280                 285             


Pro Asp Thr Pro Gln Gly Ser Gln Leu Asn Cys Glu Thr His Asp Leu 
    290                 295                 300                 


Lys Glu Ile Ile Cys Ser Trp Asn Pro Gly Arg Val Thr Ala Leu Val 
305                 310                 315                 320 


Gly Pro Arg Ala Thr Ser Tyr Thr Leu Val Glu Ser Phe Ser Gly Lys 
                325                 330                 335     


Tyr Val Arg Leu Lys Arg Ala Glu Ala Pro Thr Asn Glu Ser Tyr Gln 
            340                 345                 350         


Leu Leu Phe Gln Met Leu Pro Asn Gln Glu Ile Tyr Asn Phe Thr Leu 
        355                 360                 365             


Asn Ala His Asn Pro Leu Gly Arg Ser Gln Ser Thr Ile Leu Val Asn 
    370                 375                 380                 


Ile Thr Glu Lys Val Tyr Pro His Thr Pro Thr Ser Phe Lys Val Lys 
385                 390                 395                 400 


Asp Ile Asn Ser Thr Ala Val Lys Leu Ser Trp His Leu Pro Gly Asn 
                405                 410                 415     


Phe Ala Lys Ile Asn Phe Leu Cys Glu Ile Glu Ile Lys Lys Ser Asn 
            420                 425                 430         


Ser Val Gln Glu Gln Arg Asn Val Thr Ile Lys Gly Val Glu Asn Ser 
        435                 440                 445             


Ser Tyr Leu Val Ala Leu Asp Lys Leu Asn Pro Tyr Thr Leu Tyr Thr 
    450                 455                 460                 


Phe Arg Ile Arg Cys Ser Thr Glu Thr Phe Trp Lys Trp Ser Lys Trp 
465                 470                 475                 480 


Ser Asn Lys Lys Gln His Leu Thr Thr Glu Ala Ser Gly Ser Gly Ser 
                485                 490                 495     


Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            500                 505                 510         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        515                 520                 525             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    530                 535                 540                 


Ser His Glu Asp Pro Gln Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
545                 550                 555                 560 


Gln Val His Asn Ala Lys Thr Lys Pro Arg Glu Gln Gln Tyr Asn Ser 
                565                 570                 575     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asn Trp Leu 
            580                 585                 590         


Asp Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        595                 600                 605             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    610                 615                 620                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
625                 630                 635                 640 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                645                 650                 655     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            660                 665                 670         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        675                 680                 685             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    690                 695                 700                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
705                 710                 715                 720 


Leu Ser Pro Gly Lys 
                725 


<210>  8
<211>  949
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  8

Gln Lys Lys Gly Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu 
1               5                   10                  15      


Gln Val Trp Asn Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly 
            20                  25                  30          


Thr Asp Tyr Glu Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln 
        35                  40                  45              


Leu Glu Lys Thr Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr 
    50                  55                  60                  


Glu Ile Thr Ile Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys 
65                  70                  75                  80  


Phe Thr Leu Asn Glu Gln Asn Val Ser Leu Ile Pro Asp Thr Pro Glu 
                85                  90                  95      


Ile Leu Asn Leu Ser Ala Asp Phe Ser Thr Ser Thr Leu Tyr Leu Lys 
            100                 105                 110         


Trp Asn Asp Arg Gly Ser Val Phe Pro His Arg Ser Asn Val Ile Trp 
        115                 120                 125             


Glu Ile Lys Val Leu Arg Lys Glu Ser Met Glu Leu Val Lys Leu Val 
    130                 135                 140                 


Thr His Asn Thr Thr Leu Asn Gly Lys Asp Thr Leu His His Trp Ser 
145                 150                 155                 160 


Trp Ala Ser Asp Met Pro Leu Glu Cys Ala Ile His Phe Val Glu Ile 
                165                 170                 175     


Arg Cys Tyr Ile Asp Asn Leu His Phe Ser Gly Leu Glu Glu Trp Ser 
            180                 185                 190         


Asp Trp Ser Pro Val Lys Asn Ile Ser Trp Ile Pro Asp Ser Gln Thr 
        195                 200                 205             


Lys Val Phe Pro Gln Asp Lys Val Val Pro Val Gly Ser Asp Ile Thr 
    210                 215                 220                 


Phe Cys Cys Val Ser Gln Glu Lys Val Leu Ser Ala Leu Ile Gly Arg 
225                 230                 235                 240 


Thr Asn Cys Pro Leu Ile His Leu Asp Gly Glu Asn Val Ala Ile Lys 
                245                 250                 255     


Val Arg Asn Val Ser Ala Ser Ala Ser Ser Gly Thr Asn Val Val Phe 
            260                 265                 270         


Ile Thr Glu Asp Asp Ile Phe Gly Thr Val Ile Phe Ala Gly Tyr Pro 
        275                 280                 285             


Pro Asp Thr Pro Gln Gln Leu Asn Cys Glu Thr His Asp Leu Lys Glu 
    290                 295                 300                 


Ile Ile Cys Ser Trp Asn Pro Gly Arg Val Thr Ala Leu Val Gly Pro 
305                 310                 315                 320 


Arg Ala Thr Ser Tyr Thr Leu Val Glu Ser Phe Ser Gly Lys Tyr Val 
                325                 330                 335     


Arg Leu Lys Arg Ala Glu Ala Pro Thr Asn Glu Ser Tyr Gln Leu Leu 
            340                 345                 350         


Phe Gln Met Leu Pro Asn Gln Glu Ile Tyr Asn Phe Thr Leu Asn Ala 
        355                 360                 365             


His Asn Pro Leu Gly Arg Ser Gln Ser Thr Ile Leu Val Asn Ile Thr 
    370                 375                 380                 


Glu Lys Val Tyr Pro His Thr Pro Thr Ser Phe Lys Val Lys Asp Ile 
385                 390                 395                 400 


Asn Ser Thr Ala Val Lys Leu Ser Trp His Leu Pro Gly Asn Phe Ala 
                405                 410                 415     


Lys Ile Asn Phe Leu Cys Glu Ile Glu Ile Lys Lys Ser Asn Ser Val 
            420                 425                 430         


Gln Glu Gln Arg Asn Val Thr Ile Lys Gly Val Glu Asn Ser Ser Tyr 
        435                 440                 445             


Leu Val Ala Leu Asp Lys Leu Asn Pro Tyr Thr Leu Tyr Thr Phe Arg 
    450                 455                 460                 


Ile Arg Cys Ser Thr Glu Thr Phe Trp Lys Trp Ser Lys Trp Ser Asn 
465                 470                 475                 480 


Lys Lys Gln His Leu Thr Thr Glu Ala Ser Gly Gly Gly Gly Ser Gly 
                485                 490                 495     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            500                 505                 510         


Gly Gly Ser Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys Ile Val 
        515                 520                 525             


Asn Glu Gly Lys Lys Met Arg Cys Glu Trp Asp Arg Gly Arg Glu Thr 
    530                 535                 540                 


His Leu Glu Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr His Glu 
545                 550                 555                 560 


Leu Ala Asp Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys Thr Val 
                565                 570                 575     


Asp Tyr Ser Thr Val Tyr Phe Val Asn Ile Glu Val Trp Val Glu Ala 
            580                 585                 590         


Glu Asn Ala Leu Gly Lys Val Thr Ser Asp His Ile Asn Phe Asp Pro 
        595                 600                 605             


Val Asp Lys Val Lys Pro Asn Pro Pro His Asn Leu Ser Val Ile Asn 
    610                 615                 620                 


Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn Pro Ser 
625                 630                 635                 640 


Ile Lys Ser Val Met Ile Leu Lys Tyr Asn Ile Gln Tyr Arg Thr Lys 
                645                 650                 655     


Asp Ala Ser Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala Ser Thr 
            660                 665                 670         


Arg Ser Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu Tyr Val 
        675                 680                 685             


Phe Arg Ile Arg Cys Met Lys Glu Asp Gly Glu Gly Tyr Trp Ser Asp 
    690                 695                 700                 


Trp Ser Glu Glu Ala Ser Gly Ile Thr Tyr Glu Asp Gly Ser Gly Ser 
705                 710                 715                 720 


Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                725                 730                 735     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            740                 745                 750         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        755                 760                 765             


Ser His Glu Asp Pro Gln Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    770                 775                 780                 


Gln Val His Asn Ala Lys Thr Lys Pro Arg Glu Gln Gln Tyr Asn Ser 
785                 790                 795                 800 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asn Trp Leu 
                805                 810                 815     


Asp Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            820                 825                 830         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        835                 840                 845             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    850                 855                 860                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
865                 870                 875                 880 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                885                 890                 895     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            900                 905                 910         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        915                 920                 925             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    930                 935                 940                 


Leu Ser Pro Gly Lys 
945                 


<210>  9
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  9

Gln Lys Lys Gly Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu 
1               5                   10                  15      


Gln Val Trp Asn Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly 
            20                  25                  30          


Thr Asp Tyr Glu Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln 
        35                  40                  45              


Leu Glu Lys Thr Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr 
    50                  55                  60                  


Glu Ile Thr Ile Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys 
65                  70                  75                  80  


Phe Thr Leu Asn Glu Gln Asn Val Ser Leu Ile Pro Asp Thr Pro Glu 
                85                  90                  95      


Ile Leu Asn Leu Ser Ala Asp Phe Ser Thr Ser Thr Leu Tyr Leu Lys 
            100                 105                 110         


Trp Asn Asp Arg Gly Ser Val Phe Pro His Arg Ser Asn Val Ile Trp 
        115                 120                 125             


Glu Ile Lys Val Leu Arg Lys Glu Ser Met Glu Leu Val Lys Leu Val 
    130                 135                 140                 


Thr His Asn Thr Thr Leu Asn Gly Lys Asp Thr Leu His His Trp Ser 
145                 150                 155                 160 


Trp Ala Ser Asp Met Pro Leu Glu Cys Ala Ile His Phe Val Glu Ile 
                165                 170                 175     


Arg Cys Tyr Ile Asp Asn Leu His Phe Ser Gly Leu Glu Glu Trp Ser 
            180                 185                 190         


Asp Trp Ser Pro Val Lys Asn Ile Ser Trp Ile Pro Asp Ser Gln Thr 
        195                 200                 205             


Lys Val Phe Pro Gln Asp Lys Val Val Pro Val Gly Ser Asp Ile Thr 
    210                 215                 220                 


Phe Cys Cys Val Ser Gln Glu Lys Val Leu Ser Ala Leu Ile Gly Arg 
225                 230                 235                 240 


Thr Asp Cys Pro Leu Ile His Leu Asp Gly Glu Asn Val Ala Ile Lys 
                245                 250                 255     


Val Arg Asn Val Ser Ala Ser Ala Ser Ser Gly Thr Asn Val Val Phe 
            260                 265                 270         


Ile Thr Glu Asp Asp Ile Phe Gly Thr Val Ile Phe Ala Gly Tyr Pro 
        275                 280                 285             


Pro Asp Thr Pro Gln Gln Leu Asn Cys Glu Thr His Asp Leu Lys Glu 
    290                 295                 300                 


Ile Ile Cys Ser Trp Asn Pro Gly Arg Val Thr Ala Leu Val Gly Pro 
305                 310                 315                 320 


Arg Ala Thr Ser Tyr Thr Leu Val Glu Ser Phe Ser Gly Lys Tyr Val 
                325                 330                 335     


Arg Leu Lys Arg Ala Glu Ala Pro Thr Asn Glu Ser Tyr Gln Leu Leu 
            340                 345                 350         


Phe Gln Met Leu Pro Asn Gln Glu Ile Tyr Asn Phe Thr Leu Asn Ala 
        355                 360                 365             


His Asn Pro Leu Gly Arg Ser Gln Ser Thr Ile Leu Val Asn Ile Thr 
    370                 375                 380                 


Glu Lys Val Tyr Pro His Thr Pro Thr Ser Phe Lys Val Lys Asp Ile 
385                 390                 395                 400 


Asn Ser Thr Ala Val Lys Leu Ser Trp His Leu Pro Gly Asn Phe Ala 
                405                 410                 415     


Lys Ile Asn Phe Leu Cys Glu Ile Glu Ile Lys Lys Ser Asn Ser Val 
            420                 425                 430         


Gln Glu Gln Arg Asn Val Thr Ile Lys Gly Val Glu Asn Ser Ser Tyr 
        435                 440                 445             


Leu Val Ala Leu Asp Lys Leu Asn Pro Tyr Thr Leu Tyr Thr Phe Arg 
    450                 455                 460                 


Ile Arg Cys Ser Thr Glu Thr Phe Trp Lys Trp Ser Lys Trp Ser Asn 
465                 470                 475                 480 


Lys Lys Gln His Leu Thr Thr Glu Ala Ser Gly Ser Gly Ser Gly Ser 
                485                 490                 495     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            500                 505                 510         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        515                 520                 525             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    530                 535                 540                 


Glu Asp Pro Gln Val Lys Phe Asn Trp Tyr Val Asp Gly Val Gln Val 
545                 550                 555                 560 


His Asn Ala Lys Thr Lys Pro Arg Glu Gln Gln Tyr Asn Ser Thr Tyr 
                565                 570                 575     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asn Trp Leu Asp Gly 
            580                 585                 590         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        595                 600                 605             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    610                 615                 620                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
625                 630                 635                 640 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                645                 650                 655     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            660                 665                 670         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        675                 680                 685             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    690                 695                 700                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
705                 710                 715                 720 


Pro Gly Lys 
            


<210>  10
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  10

Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly 
1               5                   10                  15      


Lys Lys Met Arg Cys Glu Trp Asp Arg Gly Arg Glu Thr His Leu Glu 
            20                  25                  30          


Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr His Glu Leu Ala Asp 
        35                  40                  45              


Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser 
    50                  55                  60                  


Thr Val Tyr Phe Val Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala 
65                  70                  75                  80  


Leu Gly Lys Val Thr Ser Asp His Ile Asn Phe Asp Pro Val Asp Lys 
                85                  90                  95      


Val Lys Pro Asn Pro Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu 
            100                 105                 110         


Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser 
        115                 120                 125             


Val Met Ile Leu Lys Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser 
    130                 135                 140                 


Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser 
145                 150                 155                 160 


Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile 
                165                 170                 175     


Arg Cys Met Lys Glu Asp Gly Glu Gly Tyr Trp Ser Asp Trp Ser Glu 
            180                 185                 190         


Glu Ala Ser Gly Ile Thr Tyr Glu Asp Gly Ser Gly Ser Gly Ser Asp 
        195                 200                 205             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    210                 215                 220                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
225                 230                 235                 240 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                245                 250                 255     


Asp Pro Gln Val Lys Phe Asn Trp Tyr Val Asp Gly Val Gln Val His 
            260                 265                 270         


Asn Ala Lys Thr Lys Pro Arg Glu Gln Gln Tyr Asn Ser Thr Tyr Arg 
        275                 280                 285             


Val Val Ser Val Leu Thr Val Leu His Gln Asn Trp Leu Asp Gly Lys 
    290                 295                 300                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
305                 310                 315                 320 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                325                 330                 335     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            340                 345                 350         


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        355                 360                 365             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    370                 375                 380                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
385                 390                 395                 400 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                405                 410                 415     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            420                 425                 430         


Gly Lys 
        


