                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> COMPOSITIONS AND METHODS FOR TREATING DISORDERS CHARACTERIZED BY 
      A DEFECT IN GPR56 EXPRESSION OR ACTIVITY

<130> 167705.016501/PCT

<140> PCT/US2019/042618
<141> 2019-07-19

<150> 62/700,595
<151> 2018-07-19

<160> 11     

<170> PatentIn version 3.5

<210> 1
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1
Thr Tyr Phe Ala Val Leu Met Val Ser 
1               5                   


<210> 2
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2
Thr Tyr Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val 
1               5                   10                  15      


His Lys His Tyr Leu Ser 
            20          


<210> 3
<211> 687
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr 
1               5                   10                  15      


Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val 
            20                  25                  30          


Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg 
        35                  40                  45              


Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly 
    50                  55                  60                  


Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg 
65                  70                  75                  80  


Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln 
                85                  90                  95      


Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile 
            100                 105                 110         


Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser 
        115                 120                 125             


Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro 
    130                 135                 140                 


Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val 
145                 150                 155                 160 


Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys 
                165                 170                 175     


Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile 
            180                 185                 190         


Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly 
        195                 200                 205             


Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val 
    210                 215                 220                 


Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg 
225                 230                 235                 240 


Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly 
                245                 250                 255     


Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val 
            260                 265                 270         


Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu 
        275                 280                 285             


Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Tyr Asn Ser Ala 
    290                 295                 300                 


His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Phe 
305                 310                 315                 320 


Gly Glu Ile Gln Gly Asp Lys Ser Glu Met Ile Trp Asn Phe His Cys 
                325                 330                 335     


Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Gln Pro Gly Tyr Glu 
            340                 345                 350         


Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr 
        355                 360                 365             


Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly Asp Leu 
    370                 375                 380                 


Ser Thr Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp 
385                 390                 395                 400 


Val Val Asp Trp Ile Gln Gln Asp Asp Gly Ser Val His Lys Ser Ile 
                405                 410                 415     


Asn Arg Ser Leu Ile Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly 
            420                 425                 430         


Arg Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly 
        435                 440                 445             


Ser Ser Glu Glu Arg Glu Ala Phe Thr Arg Ala Asn His Leu Asn Lys 
    450                 455                 460                 


Leu Ala Glu Lys Glu Glu Thr Gly Met Ala Met Arg Ile Arg Val Gly 
465                 470                 475                 480 


Gln Ser Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr 
                485                 490                 495     


Asn Asn Thr Ala Glu Glu Tyr Val Cys Arg Leu Leu Leu Cys Ala Arg 
            500                 505                 510         


Thr Val Ser Tyr Asn Gly Ile Leu Gly Pro Glu Cys Gly Thr Lys Tyr 
        515                 520                 525             


Leu Leu Asn Leu Asn Leu Glu Pro Phe Ser Glu Lys Ser Val Pro Leu 
    530                 535                 540                 


Cys Ile Leu Tyr Glu Lys Tyr Arg Asp Cys Leu Thr Glu Ser Asn Leu 
545                 550                 555                 560 


Ile Lys Val Arg Ala Leu Leu Val Glu Pro Val Ile Asn Ser Tyr Leu 
                565                 570                 575     


Leu Ala Glu Arg Asp Leu Tyr Leu Glu Asn Pro Glu Ile Lys Ile Arg 
            580                 585                 590         


Ile Leu Gly Glu Pro Lys Gln Lys Arg Lys Leu Val Ala Glu Val Ser 
        595                 600                 605             


Leu Gln Asn Pro Leu Pro Val Ala Leu Glu Gly Cys Thr Phe Thr Val 
    610                 615                 620                 


Glu Gly Ala Gly Leu Thr Glu Glu Gln Lys Thr Val Glu Ile Pro Asp 
625                 630                 635                 640 


Pro Val Glu Ala Gly Glu Glu Val Lys Val Arg Met Asp Leu Leu Pro 
                645                 650                 655     


Leu His Met Gly Leu His Lys Leu Val Val Asn Phe Glu Ser Asp Lys 
            660                 665                 670         


Leu Lys Ala Val Lys Gly Phe Arg Asn Val Ile Ile Gly Pro Ala 
        675                 680                 685         


<210> 4
<211> 3937
<212> DNA
<213> Homo sapiens

<400> 4
ataagttagc gccgctctcc gcctcggcag tgccagccgc cagtggtcgc acttggaggg       60

tctcgccgcc agtggaagga gccaccgccc ccgcccgacc atggccgagg agctggtctt      120

agagaggtgt gatctggagc tggagaccaa tggccgagac caccacacgg ccgacctgtg      180

ccgggagaag ctggtggtgc gacggggcca gcccttctgg ctgaccctgc actttgaggg      240

ccgcaactac gaggccagtg tagacagtct caccttcagt gtcgtgaccg gcccagcccc      300

tagccaggag gccgggacca aggcccgttt tccactaaga gatgctgtgg aggagggtga      360

ctggacagcc accgtggtgg accagcaaga ctgcaccctc tcgctgcagc tcaccacccc      420

ggccaacgcc cccatcggcc tgtatcgcct cagcctggag gcctccactg gctaccaggg      480

atccagcttt gtgctgggcc acttcatttt gctcttcaac gcctggtgcc cagcggatgc      540

tgtgtacctg gactcggaag aggagcggca ggagtatgtc ctcacccagc agggctttat      600

ctaccagggc tcggccaagt tcatcaagaa cataccttgg aattttgggc agtttgaaga      660

tgggatccta gacatctgcc tgatccttct agatgtcaac cccaagttcc tgaagaacgc      720

cggccgtgac tgctcccgcc gcagcagccc cgtctacgtg ggccgggtgg tgagtggcat      780

ggtcaactgc aacgatgacc agggtgtgct gctgggacgc tgggacaaca actacgggga      840

cggcgtcagc cccatgtcct ggatcggcag cgtggacatc ctgcggcgct ggaagaacca      900

cggctgccag cgcgtcaagt atggccagtg ctgggtcttc gccgccgtgg cctgcacagt      960

gctgaggtgc ctgggcatcc ctacccgcgt cgtgaccaac tacaactcgg cccatgacca     1020

gaacagcaac cttctcatcg agtacttccg caatgagttt ggggagatcc agggtgacaa     1080

gagcgagatg atctggaact tccactgctg ggtggagtcg tggatgacca ggccggacct     1140

gcagccgggg tacgagggct ggcaggccct ggacccaacg ccccaggaga agagcgaagg     1200

gacgtactgc tgtggcccag ttccagttcg tgccatcaag gagggcgacc tgagcaccaa     1260

gtacgatgcg ccctttgtct ttgcggaggt caatgccgac gtggtagact ggatccagca     1320

ggacgatggg tctgtgcaca aatccatcaa ccgttccctg atcgttgggc tgaagatcag     1380

cactaagagc gtgggccgag acgagcggga ggatatcacc cacacctaca aatacccaga     1440

ggggtcctca gaggagaggg aggccttcac aagggcgaac cacctgaaca aactggccga     1500

gaaggaggag acagggatgg ccatgcggat ccgtgtgggc cagagcatga acatgggcag     1560

tgactttgac gtctttgccc acatcaccaa caacaccgct gaggagtacg tctgccgcct     1620

cctgctctgt gcccgcaccg tcagctacaa tgggatcttg gggcccgagt gtggcaccaa     1680

gtacctgctc aacctcaacc tggagccttt ctctgagaag agcgttcctc tttgcatcct     1740

ctatgagaaa taccgtgact gccttacgga gtccaacctc atcaaggtgc gggccctcct     1800

cgtggagcca gttatcaaca gctacctgct ggctgagagg gacctctacc tggagaatcc     1860

agaaatcaag atccggatcc ttggggagcc caagcagaaa cgcaagctgg tggctgaggt     1920

gtccctgcag aacccgctcc ctgtggccct ggaaggctgc accttcactg tggagggggc     1980

cggcctgact gaggagcaga agacggtgga gatcccagac cccgtggagg caggggagga     2040

agttaaggtg agaatggacc tgctgccgct ccacatgggc ctccacaagc tggtggtgaa     2100

cttcgagagc gacaagctga aggctgtgaa gggcttccgg aatgtcatca ttggccccgc     2160

ctaagggacc cctgctccca gcctgctgag agcccccacc ttgatcccaa tccttatccc     2220

aagctagtga gcaaaatatg ccccttcttg ggccccagac cccagggcag ggtgggcagc     2280

ctatgggggc tctcggaaat ggaatgtgcc cctggcccat ctcagcctcc tgagcctgtg     2340

ggtccccact cacccccttt gctgtgagga atgctctgtg ccagaaacag tgggagccct     2400

gaccttggct gactggggct ggggtgagag aggaaagacc tacattccct ctcctgccca     2460

gatgcccttt ggaaagccat tgaccaccca ccatattgtt tgatctactt catagctcct     2520

tggagcaggc aaaaaaggga cagcatgccc cttggctgga tcagggaatc cagctcccta     2580

gactgcatcc cgtacctctt cccatgactg cacccagctc caggggccct tgggacagcc     2640

agagctgggt ggggacagtg ataggcccaa ggtcccctcc acatcccagc agcccaagct     2700

taatagccct ccccctcaac ctcaccattg tgaagcacct actatgtgct gggtgcctcc     2760

cacacttgct ggggctcacg gggcctccaa cccatttaat caccatggga aactgttgtg     2820

ggcgctgctt ccaggataag gagactgagg cttagagaga ggaggcagcc ccctccacac     2880

cagtggcctc gtggttatta gcaaggctgg gtaatgtgaa ggcccaagag cagagtctgg     2940

gcctctgact ctgagtccac tgctccattt ataaccccag cctgacctga gactgtcgga     3000

gaggctgtct ggggccttta tcaaaaaaag actcagccaa gacaaggagg tagagagggg     3060

actgggggac tgggagtcag agccctggct gggttcaggt cccacgtctg gccaggcact     3120

gccttctcct ctctgggcct ttgtttcctt gttggtcaga ggagtgattg aaccagctca     3180

tctccaagga tcctctccac tccatgtttg caatgctttt atatggccca gccttgtaaa     3240

taaccacaag gtccactccc tgctccacga agccttaagc cataggccca ggatatttct     3300

gagagtgaaa ccatgactgt gaccaccttc tgtccccagc cctgtcctgg ttccttccta     3360

tgcccaggta ccacccttca gaccccagtt ctaggggaga agagccctgg acacccctgc     3420

tctacccatg agcctgcccg ctgcaatgcc tagacttccc aacagcctta gctgccagtg     3480

ctggtcacta accaacaagg ttggcacccc agctacccct tctttgcagg gctaaggccc     3540

ccaaacatag cccctgcccc ggaggaagct tggggaaccc atgagttgtc agctttgact     3600

ttatctcctg ctctttctac atgactgggc ctcccttggg ctggaagaat tggggattct     3660

ctattggagg tgagatcaca gcctccaggg ccccccaaat cccagggaag gacttggaga     3720

gaatcatgct gttgcattta gaactttctg ctttgcacag gaaagagtca cacaattaat     3780

caacatgtat attttctcta tacatagagc tctatttctc tacggtttta taaaagcctt     3840

gggttccaac caggcagtag atgtgcttct gaaccgcaag gagcaaacac tgaaataaaa     3900

tagtttattt ttcacactca aaaaaaaaaa aaaaaaa                              3937


<210> 5
<211> 687
<212> PRT
<213> Homo sapiens

<400> 5
Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Thr 
            260                 265                 270         


Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 
        275                 280                 285             


Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr 
305                 310                 315                 320 


Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His Gln 
                325                 330                 335     


Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu Asp 
            340                 345                 350         


Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Thr 
        355                 360                 365             


Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr Tyr 
    370                 375                 380                 


Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 
385                 390                 395                 400 


His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 
                405                 410                 415     


Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Arg Lys Pro 
            420                 425                 430         


Arg Asp Tyr Thr Ile Lys Val His Met Asn Leu Leu Leu Ala Val Phe 
        435                 440                 445             


Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu Pro Val Ala Leu Thr Gly 
    450                 455                 460                 


Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile Phe Leu His Phe Ser Leu 
465                 470                 475                 480 


Leu Thr Cys Leu Ser Trp Met Gly Leu Glu Gly Tyr Asn Leu Tyr Arg 
                485                 490                 495     


Leu Val Val Glu Val Phe Gly Thr Tyr Val Pro Gly Tyr Leu Leu Lys 
            500                 505                 510         


Leu Ser Ala Met Gly Trp Gly Phe Pro Ile Phe Leu Val Thr Leu Val 
        515                 520                 525             


Ala Leu Val Asp Val Asp Asn Tyr Gly Pro Ile Ile Leu Ala Val His 
    530                 535                 540                 


Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser Met Cys Trp Ile Arg Asp 
545                 550                 555                 560 


Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly Leu Phe Ser Leu Val Phe 
                565                 570                 575     


Leu Phe Asn Met Ala Met Leu Ala Thr Met Val Val Gln Ile Leu Arg 
            580                 585                 590         


Leu Arg Pro His Thr Gln Lys Trp Ser His Val Leu Thr Leu Leu Gly 
        595                 600                 605             


Leu Ser Leu Val Leu Gly Leu Pro Trp Ala Leu Ile Phe Phe Ser Phe 
    610                 615                 620                 


Ala Ser Gly Thr Phe Gln Leu Val Val Leu Tyr Leu Phe Ser Ile Ile 
625                 630                 635                 640 


Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile Trp Tyr Trp Ser Met Arg 
                645                 650                 655     


Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu Lys Ser Asn Ser Asp Ser 
            660                 665                 670         


Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr Ser Ser Ser Arg Ile 
        675                 680                 685         


<210> 6
<211> 518
<212> PRT
<213> Homo sapiens

<400> 6
Met Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys 
1               5                   10                  15      


His Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln 
            20                  25                  30          


Gln Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly 
        35                  40                  45              


Asp Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys 
    50                  55                  60                  


Leu Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln 
65                  70                  75                  80  


Glu Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg 
                85                  90                  95      


Thr Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg 
            100                 105                 110         


Leu Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn 
        115                 120                 125             


Ser Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn 
    130                 135                 140                 


Thr Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His 
145                 150                 155                 160 


Gln Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu 
                165                 170                 175     


Asp Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu 
            180                 185                 190         


Thr Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr 
        195                 200                 205             


Tyr Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His 
    210                 215                 220                 


Lys His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala 
225                 230                 235                 240 


Leu Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Val Pro 
                245                 250                 255     


Leu Pro Cys Arg Arg Lys Pro Arg Asp Tyr Thr Ile Lys Val His Met 
            260                 265                 270         


Asn Leu Leu Leu Ala Val Phe Leu Leu Asp Thr Ser Phe Leu Leu Ser 
        275                 280                 285             


Glu Pro Val Ala Leu Thr Gly Ser Glu Ala Gly Cys Arg Ala Ser Ala 
    290                 295                 300                 


Ile Phe Leu His Phe Ser Leu Leu Thr Cys Leu Ser Trp Met Gly Leu 
305                 310                 315                 320 


Glu Gly Tyr Asn Leu Tyr Arg Leu Val Val Glu Val Phe Gly Thr Tyr 
                325                 330                 335     


Val Pro Gly Tyr Leu Leu Lys Leu Ser Ala Met Gly Trp Gly Phe Pro 
            340                 345                 350         


Ile Phe Leu Val Thr Leu Val Ala Leu Val Asp Val Asp Asn Tyr Gly 
        355                 360                 365             


Pro Ile Ile Leu Ala Val His Arg Thr Pro Glu Gly Val Ile Tyr Pro 
    370                 375                 380                 


Ser Met Cys Trp Ile Arg Asp Ser Leu Val Ser Tyr Ile Thr Asn Leu 
385                 390                 395                 400 


Gly Leu Phe Ser Leu Val Phe Leu Phe Asn Met Ala Met Leu Ala Thr 
                405                 410                 415     


Met Val Val Gln Ile Leu Arg Leu Arg Pro His Thr Gln Lys Trp Ser 
            420                 425                 430         


His Val Leu Thr Leu Leu Gly Leu Ser Leu Val Leu Gly Leu Pro Trp 
        435                 440                 445             


Ala Leu Ile Phe Phe Ser Phe Ala Ser Gly Thr Phe Gln Leu Val Val 
    450                 455                 460                 


Leu Tyr Leu Phe Ser Ile Ile Thr Ser Phe Gln Gly Phe Leu Ile Phe 
465                 470                 475                 480 


Ile Trp Tyr Trp Ser Met Arg Leu Gln Ala Arg Gly Gly Pro Ser Pro 
                485                 490                 495     


Leu Lys Ser Asn Ser Asp Ser Ala Arg Leu Pro Ile Ser Ser Gly Ser 
            500                 505                 510         


Thr Ser Ser Ser Arg Ile 
        515             


<210> 7
<211> 3813
<212> DNA
<213> Homo sapiens

<400> 7
agacaggcgg agcctcacct ggggctgccc gccagcccag acaagctcag actgggtgcc       60

tgtggccctg ggaggaggtg gaaggggagg agcaggccac acaggcacag gccggtgagg      120

gacctgccca gacctggagg gtctcgctct gtcacacagg ctggagtgca gtggtgtgat      180

cttggctcat cgtaacctcc acctcccggg ttcaagtgat tctcatgcct cagcctcccg      240

agtagctggg attacaggtg gtgacttcca agagtgactc cgtcggagga aaatgactcc      300

ccagtcgctg ctgcagacga cactgttcct gctgagtctg ctcttcctgg tccaaggtgc      360

ccacggcagg ggccacaggg aagactttcg cttctgcagc cagcggaacc agacacacag      420

gagcagcctc cactacaaac ccacaccaga cctgcgcatc tccatcgaga actccgaaga      480

ggccctcaca gtccatgccc ctttccctgc agcccaccct gcttcccgat ccttccctga      540

ccccaggggc ctctaccact tctgcctcta ctggaaccga catgctggga gattacatct      600

tctctatggc aagcgtgact tcttgctgag tgacaaagcc tctagcctcc tctgcttcca      660

gcaccaggag gagagcctgg ctcagggccc cccgctgtta gccacttctg tcacctcctg      720

gtggagccct cagaacatca gcctgcccag tgccgccagc ttcaccttct ccttccacag      780

tcctccccac acggccgctc acaatgcctc ggtggacatg tgcgagctca aaagggacct      840

ccagctgctc agccagttcc tgaagcatcc ccagaaggcc tcaaggaggc cctcggctgc      900

ccccgccagc cagcagttgc agagcctgga gtcgaaactg acctctgtga gattcatggg      960

ggacatggtg tccttcgagg aggaccggat caacgccacg gtgtggaagc tccagcccac     1020

agccggcctc caggacctgc acatccactc ccggcaggag gaggagcaga gcgagatcat     1080

ggagtactcg gtgctgctgc ctcgaacact cttccagagg acgaaaggcc ggagcgggga     1140

ggctgagaag agactcctcc tggtggactt cagcagccaa gccctgttcc aggacaagaa     1200

ttccagccaa gtcctgggtg agaaggtctt ggggattgtg gtacagaaca ccaaagtagc     1260

caacctcacg gagcccgtgg tgctcacttt ccagcaccag ctacagccga agaatgtgac     1320

tctgcaatgt gtgttctggg ttgaagaccc cacattgagc agcccggggc attggagcag     1380

tgctgggtgt gagaccgtca ggagagaaac ccaaacatcc tgcttctgca accacttgac     1440

ctactttgca gtgctgatgg tctcctcggt ggaggtggac gccgtgcaca agcactacct     1500

gagcctcctc tcctacgtgg gctgtgtcgt ctctgccctg gcctgccttg tcaccattgc     1560

cgcctacctc tgctccagga ggaaacctcg ggactacacc atcaaggtgc acatgaacct     1620

gctgctggcc gtcttcctgc tggacacgag cttcctgctc agcgagccgg tggccctgac     1680

aggctctgag gctggctgcc gagccagtgc catcttcctg cacttctccc tgctcacctg     1740

cctttcctgg atgggcctcg aggggtacaa cctctaccga ctcgtggtgg aggtctttgg     1800

cacctatgtc cctggctacc tactcaagct gagcgccatg ggctggggct tccccatctt     1860

tctggtgacg ctggtggccc tggtggatgt ggacaactat ggccccatca tcttggctgt     1920

gcataggact ccagagggcg tcatctaccc ttccatgtgc tggatccggg actccctggt     1980

cagctacatc accaacctgg gcctcttcag cctggtgttt ctgttcaaca tggccatgct     2040

agccaccatg gtggtgcaga tcctgcggct gcgcccccac acccaaaagt ggtcacatgt     2100

gctgacactg ctgggcctca gcctggtcct tggcctgccc tgggccttga tcttcttctc     2160

ctttgcttct ggcaccttcc agcttgtcgt cctctacctt ttcagcatca tcacctcctt     2220

ccaaggcttc ctcatcttca tctggtactg gtccatgcgg ctgcaggccc ggggtggccc     2280

ctcccctctg aagagcaact cagacagcgc caggctcccc atcagctcgg gcagcacctc     2340

gtccagccgc atctaggcct ccagcccacc tgcccatgtg atgaagcaga gattcggcct     2400

cgtcgcacac tgcctgtggc ccccgagccc ggcccagccc caggccagtc agccgcagac     2460

tttggaaagc ccaacgacca tggagagatg ggccgttgcc atggtggacg gactcccggg     2520

ctgggctttt gaattggcct tggggactac tcggctctca ctcagctccc acgggactca     2580

gaagtgcgcc gccatgctgc ctagggtact gtccccacat ctgtcccaac ccagctggag     2640

gcctggtctc tccttacaac ccctgggccc agccctcatt gctgggggcc aggccttgga     2700

tcttgagggt ctggcacatc cttaatcctg tgcccctgcc tgggacagaa atgtggctcc     2760

agttgctctg tctctcgtgg tcaccctgag ggcactctgc atcctctgtc attttaacct     2820

caggtggcac ccagggcgaa tggggcccag ggcagacctt cagggccaga gccctggcgg     2880

aggagaggcc ctttgccagg agcacagcag cagctcgcct acctctgagc ccaggccccc     2940

tccctccctc agccccccag tcctccctcc atcttccctg gggttctcct cctctcccag     3000

ggcctccttg ctccttcgtt cacagctggg ggtccccgat tccaatgctg ttttttgggg     3060

agtggtttcc aggagctgcc tggtgtctgc tgtaaatgtt tgtctactgc acaagcctcg     3120

gcctgcccct gagccaggct cggtaccgat gcgtgggctg ggctaggtcc ctctgtccat     3180

ctgggccttt gtatgagctg cattgccctt gctcaccctg accaagcaca cgcctcagag     3240

gggccctcag cctctcctga agccctcttg tggcaagaac tgtggaccat gccagtcccg     3300

tctggtttcc atcccaccac tccaaggact gagactgacc tcctctggtg acactggcct     3360

agggcctgac actctcctaa gaggttctct ccaagccccc aaatagctcc aggcgccctc     3420

ggccgcccat catggttaat tctgtccaac aaacacacac gggtagattg ctggcctgtt     3480

gtaggtggta gggacacaga tgaccgacct ggtcactcct cctgccaaca ttcagtctgg     3540

tatgtgaggc gtgcgtgaag caagaactcc tggagctaca gggacaggga gccatcattc     3600

ctgcctggga atcctggaag acttcctgca ggagtcagcg ttcaatcttg accttgaaga     3660

tgggaaggat gttcttttta cgtaccaatt cttttgtctt ttgatattaa aaagaagtac     3720

atgttcattg tagagaattt ggaaactgta gaagagaatc aagaagaaaa ataaaaatca     3780

gctgttgtaa tcacctagca aactggcgta agc                                  3813


<210> 8
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
ccatggaaga cttccgcttc tgtggcc                                           27


<210> 9
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
cagatctcag gtggttgcac aggcagg                                           27


<210> 10
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
atccatggtt atgtgtgatc tcaagaagga attgc                                  35


<210> 11
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
tctagatctc aggtggttgc acaggcagg                                         29

