                               SEQUENCE LISTING

<110> VARIAN MEDICAL SYSTEMS, INC.
 
<120> METHODS OF USE OF ULTRA-HIGH DOSE RATE RADIATION AND THERAPEUTIC 
      AGENTS

<130> 088389-1148200-17003WO

<140> PCT/US2019/042603
<141> 2019-07-19

<150> 62/700,783
<151> 2018-07-19

<160> 71    

<170> PatentIn version 3.5

<210> 1
<211> 462
<212> PRT
<213> Homo sapiens

<400> 1
Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Gly Pro Gly Arg Gly Phe Gly Lys 
            20                  25                  30          


Arg Arg His Pro Lys Lys Leu Thr Pro Leu Ala Tyr Lys Gln Phe Ile 
        35                  40                  45              


Pro Asn Val Ala Glu Lys Thr Leu Gly Ala Ser Gly Arg Tyr Glu Gly 
    50                  55                  60                  


Lys Ile Ser Arg Asn Ser Glu Arg Phe Lys Glu Leu Thr Pro Asn Tyr 
65                  70                  75                  80  


Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn Thr Gly Ala Asp Arg 
                85                  90                  95      


Leu Met Thr Gln Arg Cys Lys Asp Lys Leu Asn Ala Leu Ala Ile Ser 
            100                 105                 110         


Val Met Asn Gln Trp Pro Gly Val Lys Leu Arg Val Thr Glu Gly Trp 
        115                 120                 125             


Asp Glu Asp Gly His His Ser Glu Glu Ser Leu His Tyr Glu Gly Arg 
    130                 135                 140                 


Ala Val Asp Ile Thr Thr Ser Asp Arg Asp Arg Ser Lys Tyr Gly Met 
145                 150                 155                 160 


Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp Trp Val Tyr Tyr Glu 
                165                 170                 175     


Ser Lys Ala His Ile His Cys Ser Val Lys Ala Glu Asn Ser Val Ala 
            180                 185                 190         


Ala Lys Ser Gly Gly Cys Phe Pro Gly Ser Ala Thr Val His Leu Glu 
        195                 200                 205             


Gln Gly Gly Thr Lys Leu Val Lys Asp Leu Ser Pro Gly Asp Arg Val 
    210                 215                 220                 


Leu Ala Ala Asp Asp Gln Gly Arg Leu Leu Tyr Ser Asp Phe Leu Thr 
225                 230                 235                 240 


Phe Leu Asp Arg Asp Asp Gly Ala Lys Lys Val Phe Tyr Val Ile Glu 
                245                 250                 255     


Thr Arg Glu Pro Arg Glu Arg Leu Leu Leu Thr Ala Ala His Leu Leu 
            260                 265                 270         


Phe Val Ala Pro His Asn Asp Ser Ala Thr Gly Glu Pro Glu Ala Ser 
        275                 280                 285             


Ser Gly Ser Gly Pro Pro Ser Gly Gly Ala Leu Gly Pro Arg Ala Leu 
    290                 295                 300                 


Phe Ala Ser Arg Val Arg Pro Gly Gln Arg Val Tyr Val Val Ala Glu 
305                 310                 315                 320 


Arg Asp Gly Asp Arg Arg Leu Leu Pro Ala Ala Val His Ser Val Thr 
                325                 330                 335     


Leu Ser Glu Glu Ala Ala Gly Ala Tyr Ala Pro Leu Thr Ala Gln Gly 
            340                 345                 350         


Thr Ile Leu Ile Asn Arg Val Leu Ala Ser Cys Tyr Ala Val Ile Glu 
        355                 360                 365             


Glu His Ser Trp Ala His Arg Ala Phe Ala Pro Phe Arg Leu Ala His 
    370                 375                 380                 


Ala Leu Leu Ala Ala Leu Ala Pro Ala Arg Thr Asp Arg Gly Gly Asp 
385                 390                 395                 400 


Ser Gly Gly Gly Asp Arg Gly Gly Gly Gly Gly Arg Val Ala Leu Thr 
                405                 410                 415     


Ala Pro Gly Ala Ala Asp Ala Pro Gly Ala Gly Ala Thr Ala Gly Ile 
            420                 425                 430         


His Trp Tyr Ser Gln Leu Leu Tyr Gln Ile Gly Thr Trp Leu Leu Asp 
        435                 440                 445             


Ser Glu Ala Leu His Pro Leu Gly Met Ala Val Lys Ser Ser 
    450                 455                 460         


<210> 2
<211> 411
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Pro Ala Arg Leu Arg Pro Arg Leu His Phe Cys Leu Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Val Pro Ala Ala Trp Gly Cys Gly Pro Gly Arg 
            20                  25                  30          


Val Val Gly Ser Arg Arg Arg Pro Pro Arg Lys Leu Val Pro Leu Ala 
        35                  40                  45              


Tyr Lys Gln Phe Ser Pro Asn Val Pro Glu Lys Thr Leu Gly Ala Ser 
    50                  55                  60                  


Gly Arg Tyr Glu Gly Lys Ile Ala Arg Ser Ser Glu Arg Phe Lys Glu 
65                  70                  75                  80  


Leu Thr Pro Asn Tyr Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn 
                85                  90                  95      


Thr Gly Ala Asp Arg Leu Met Thr Gln Arg Cys Lys Asp Arg Leu Asn 
            100                 105                 110         


Ser Leu Ala Ile Ser Val Met Asn Gln Trp Pro Gly Val Lys Leu Arg 
        115                 120                 125             


Val Thr Glu Gly Trp Asp Glu Asp Gly His His Ser Glu Glu Ser Leu 
    130                 135                 140                 


His Tyr Glu Gly Arg Ala Val Asp Ile Thr Thr Ser Asp Arg Asp Arg 
145                 150                 155                 160 


Asn Lys Tyr Gly Leu Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp 
                165                 170                 175     


Trp Val Tyr Tyr Glu Ser Lys Ala His Val His Cys Ser Val Lys Ser 
            180                 185                 190         


Glu His Ser Ala Ala Ala Lys Thr Gly Gly Cys Phe Pro Ala Gly Ala 
        195                 200                 205             


Gln Val Arg Leu Glu Ser Gly Ala Arg Val Ala Leu Ser Ala Val Arg 
    210                 215                 220                 


Pro Gly Asp Arg Val Leu Ala Met Gly Glu Asp Gly Ser Pro Thr Phe 
225                 230                 235                 240 


Ser Asp Val Leu Ile Phe Leu Asp Arg Glu Pro His Arg Leu Arg Ala 
                245                 250                 255     


Phe Gln Val Ile Glu Thr Gln Asp Pro Pro Arg Arg Leu Ala Leu Thr 
            260                 265                 270         


Pro Ala His Leu Leu Phe Thr Ala Asp Asn His Thr Glu Pro Ala Ala 
        275                 280                 285             


Arg Phe Arg Ala Thr Phe Ala Ser His Val Gln Pro Gly Gln Tyr Val 
    290                 295                 300                 


Leu Val Ala Gly Val Pro Gly Leu Gln Pro Ala Arg Val Ala Ala Val 
305                 310                 315                 320 


Ser Thr His Val Ala Leu Gly Ala Tyr Ala Pro Leu Thr Lys His Gly 
                325                 330                 335     


Thr Leu Val Val Glu Asp Val Val Ala Ser Cys Phe Ala Ala Val Ala 
            340                 345                 350         


Asp His His Leu Ala Gln Leu Ala Phe Trp Pro Leu Arg Leu Phe His 
        355                 360                 365             


Ser Leu Ala Trp Gly Ser Trp Thr Pro Gly Glu Gly Val His Trp Tyr 
    370                 375                 380                 


Pro Gln Leu Leu Tyr Arg Leu Gly Arg Leu Leu Leu Glu Glu Gly Ser 
385                 390                 395                 400 


Phe His Pro Leu Gly Met Ser Gly Ala Gly Ser 
                405                 410     


<210> 3
<211> 396
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Leu Leu Thr Asn Leu Leu Pro Leu Cys Cys Leu Ala Leu Leu 
1               5                   10                  15      


Ala Leu Pro Ala Gln Ser Cys Gly Pro Gly Arg Gly Pro Val Gly Arg 
            20                  25                  30          


Arg Arg Tyr Ala Arg Lys Gln Leu Val Pro Leu Leu Tyr Lys Gln Phe 
        35                  40                  45              


Val Pro Gly Val Pro Glu Arg Thr Leu Gly Ala Ser Gly Pro Ala Glu 
    50                  55                  60                  


Gly Arg Val Ala Arg Gly Ser Glu Arg Phe Arg Asp Leu Val Pro Asn 
65                  70                  75                  80  


Tyr Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn Ser Gly Ala Asp 
                85                  90                  95      


Arg Leu Met Thr Glu Arg Cys Lys Glu Arg Val Asn Ala Leu Ala Ile 
            100                 105                 110         


Ala Val Met Asn Met Trp Pro Gly Val Arg Leu Arg Val Thr Glu Gly 
        115                 120                 125             


Trp Asp Glu Asp Gly His His Ala Gln Asp Ser Leu His Tyr Glu Gly 
    130                 135                 140                 


Arg Ala Leu Asp Ile Thr Thr Ser Asp Arg Asp Arg Asn Lys Tyr Gly 
145                 150                 155                 160 


Leu Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp Trp Val Tyr Tyr 
                165                 170                 175     


Glu Ser Arg Asn His Val His Val Ser Val Lys Ala Asp Asn Ser Leu 
            180                 185                 190         


Ala Val Arg Ala Gly Gly Cys Phe Pro Gly Asn Ala Thr Val Arg Leu 
        195                 200                 205             


Trp Ser Gly Glu Arg Lys Gly Leu Arg Glu Leu His Arg Gly Asp Trp 
    210                 215                 220                 


Val Leu Ala Ala Asp Ala Ser Gly Arg Val Val Pro Thr Pro Val Leu 
225                 230                 235                 240 


Leu Phe Leu Asp Arg Asp Leu Gln Arg Arg Ala Ser Phe Val Ala Val 
                245                 250                 255     


Glu Thr Glu Trp Pro Pro Arg Lys Leu Leu Leu Thr Pro Trp His Leu 
            260                 265                 270         


Val Phe Ala Ala Arg Gly Pro Ala Pro Ala Pro Gly Asp Phe Ala Pro 
        275                 280                 285             


Val Phe Ala Arg Arg Leu Arg Ala Gly Asp Ser Val Leu Ala Pro Gly 
    290                 295                 300                 


Gly Asp Ala Leu Arg Pro Ala Arg Val Ala Arg Val Ala Arg Glu Glu 
305                 310                 315                 320 


Ala Val Gly Val Phe Ala Pro Leu Thr Ala His Gly Thr Leu Leu Val 
                325                 330                 335     


Asn Asp Val Leu Ala Ser Cys Tyr Ala Val Leu Glu Ser His Gln Trp 
            340                 345                 350         


Ala His Arg Ala Phe Ala Pro Leu Arg Leu Leu His Ala Leu Gly Ala 
        355                 360                 365             


Leu Leu Pro Gly Gly Ala Val Gln Pro Thr Gly Met His Trp Tyr Ser 
    370                 375                 380                 


Arg Leu Leu Tyr Arg Leu Ala Glu Glu Leu Leu Gly 
385                 390                 395     


<210> 4
<211> 1447
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Ser Ala Gly Asn Ala Ala Glu Pro Gln Asp Arg Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Cys Ile Gly Ala Pro Gly Arg Pro Ala Gly Gly Gly Arg 
            20                  25                  30          


Arg Arg Arg Thr Gly Gly Leu Arg Arg Ala Ala Ala Pro Asp Arg Asp 
        35                  40                  45              


Tyr Leu His Arg Pro Ser Tyr Cys Asp Ala Ala Phe Ala Leu Glu Gln 
    50                  55                  60                  


Ile Ser Lys Gly Lys Ala Thr Gly Arg Lys Ala Pro Leu Trp Leu Arg 
65                  70                  75                  80  


Ala Lys Phe Gln Arg Leu Leu Phe Lys Leu Gly Cys Tyr Ile Gln Lys 
                85                  90                  95      


Asn Cys Gly Lys Phe Leu Val Val Gly Leu Leu Ile Phe Gly Ala Phe 
            100                 105                 110         


Ala Val Gly Leu Lys Ala Ala Asn Leu Glu Thr Asn Val Glu Glu Leu 
        115                 120                 125             


Trp Val Glu Val Gly Gly Arg Val Ser Arg Glu Leu Asn Tyr Thr Arg 
    130                 135                 140                 


Gln Lys Ile Gly Glu Glu Ala Met Phe Asn Pro Gln Leu Met Ile Gln 
145                 150                 155                 160 


Thr Pro Lys Glu Glu Gly Ala Asn Val Leu Thr Thr Glu Ala Leu Leu 
                165                 170                 175     


Gln His Leu Asp Ser Ala Leu Gln Ala Ser Arg Val His Val Tyr Met 
            180                 185                 190         


Tyr Asn Arg Gln Trp Lys Leu Glu His Leu Cys Tyr Lys Ser Gly Glu 
        195                 200                 205             


Leu Ile Thr Glu Thr Gly Tyr Met Asp Gln Ile Ile Glu Tyr Leu Tyr 
    210                 215                 220                 


Pro Cys Leu Ile Ile Thr Pro Leu Asp Cys Phe Trp Glu Gly Ala Lys 
225                 230                 235                 240 


Leu Gln Ser Gly Thr Ala Tyr Leu Leu Gly Lys Pro Pro Leu Arg Trp 
                245                 250                 255     


Thr Asn Phe Asp Pro Leu Glu Phe Leu Glu Glu Leu Lys Lys Ile Asn 
            260                 265                 270         


Tyr Gln Val Asp Ser Trp Glu Glu Met Leu Asn Lys Ala Glu Val Gly 
        275                 280                 285             


His Gly Tyr Met Asp Arg Pro Cys Leu Asn Pro Ala Asp Pro Asp Cys 
    290                 295                 300                 


Pro Ala Thr Ala Pro Asn Lys Asn Ser Thr Lys Pro Leu Asp Met Ala 
305                 310                 315                 320 


Leu Val Leu Asn Gly Gly Cys His Gly Leu Ser Arg Lys Tyr Met His 
                325                 330                 335     


Trp Gln Glu Glu Leu Ile Val Gly Gly Thr Val Lys Asn Ser Thr Gly 
            340                 345                 350         


Lys Leu Val Ser Ala His Ala Leu Gln Thr Met Phe Gln Leu Met Thr 
        355                 360                 365             


Pro Lys Gln Met Tyr Glu His Phe Lys Gly Tyr Glu Tyr Val Ser His 
    370                 375                 380                 


Ile Asn Trp Asn Glu Asp Lys Ala Ala Ala Ile Leu Glu Ala Trp Gln 
385                 390                 395                 400 


Arg Thr Tyr Val Glu Val Val His Gln Ser Val Ala Gln Asn Ser Thr 
                405                 410                 415     


Gln Lys Val Leu Ser Phe Thr Thr Thr Thr Leu Asp Asp Ile Leu Lys 
            420                 425                 430         


Ser Phe Ser Asp Val Ser Val Ile Arg Val Ala Ser Gly Tyr Leu Leu 
        435                 440                 445             


Met Leu Ala Tyr Ala Cys Leu Thr Met Leu Arg Trp Asp Cys Ser Lys 
    450                 455                 460                 


Ser Gln Gly Ala Val Gly Leu Ala Gly Val Leu Leu Val Ala Leu Ser 
465                 470                 475                 480 


Val Ala Ala Gly Leu Gly Leu Cys Ser Leu Ile Gly Ile Ser Phe Asn 
                485                 490                 495     


Ala Ala Thr Thr Gln Val Leu Pro Phe Leu Ala Leu Gly Val Gly Val 
            500                 505                 510         


Asp Asp Val Phe Leu Leu Ala His Ala Phe Ser Glu Thr Gly Gln Asn 
        515                 520                 525             


Lys Arg Ile Pro Phe Glu Asp Arg Thr Gly Glu Cys Leu Lys Arg Thr 
    530                 535                 540                 


Gly Ala Ser Val Ala Leu Thr Ser Ile Ser Asn Val Thr Ala Phe Phe 
545                 550                 555                 560 


Met Ala Ala Leu Ile Pro Ile Pro Ala Leu Arg Ala Phe Ser Leu Gln 
                565                 570                 575     


Ala Ala Val Val Val Val Phe Asn Phe Ala Met Val Leu Leu Ile Phe 
            580                 585                 590         


Pro Ala Ile Leu Ser Met Asp Leu Tyr Arg Arg Glu Asp Arg Arg Leu 
        595                 600                 605             


Asp Ile Phe Cys Cys Phe Thr Ser Pro Cys Val Ser Arg Val Ile Gln 
    610                 615                 620                 


Val Glu Pro Gln Ala Tyr Thr Asp Thr His Asp Asn Thr Arg Tyr Ser 
625                 630                 635                 640 


Pro Pro Pro Pro Tyr Ser Ser His Ser Phe Ala His Glu Thr Gln Ile 
                645                 650                 655     


Thr Met Gln Ser Thr Val Gln Leu Arg Thr Glu Tyr Asp Pro His Thr 
            660                 665                 670         


His Val Tyr Tyr Thr Thr Ala Glu Pro Arg Ser Glu Ile Ser Val Gln 
        675                 680                 685             


Pro Val Thr Val Thr Gln Asp Thr Leu Ser Cys Gln Ser Pro Glu Ser 
    690                 695                 700                 


Thr Ser Ser Thr Arg Asp Leu Leu Ser Gln Phe Ser Asp Ser Ser Leu 
705                 710                 715                 720 


His Cys Leu Glu Pro Pro Cys Thr Lys Trp Thr Leu Ser Ser Phe Ala 
                725                 730                 735     


Glu Lys His Tyr Ala Pro Phe Leu Leu Lys Pro Lys Ala Lys Val Val 
            740                 745                 750         


Val Ile Phe Leu Phe Leu Gly Leu Leu Gly Val Ser Leu Tyr Gly Thr 
        755                 760                 765             


Thr Arg Val Arg Asp Gly Leu Asp Leu Thr Asp Ile Val Pro Arg Glu 
    770                 775                 780                 


Thr Arg Glu Tyr Asp Phe Ile Ala Ala Gln Phe Lys Tyr Phe Ser Phe 
785                 790                 795                 800 


Tyr Asn Met Tyr Ile Val Thr Gln Lys Ala Asp Tyr Pro Asn Ile Gln 
                805                 810                 815     


His Leu Leu Tyr Asp Leu His Arg Ser Phe Ser Asn Val Lys Tyr Val 
            820                 825                 830         


Met Leu Glu Glu Asn Lys Gln Leu Pro Lys Met Trp Leu His Tyr Phe 
        835                 840                 845             


Arg Asp Trp Leu Gln Gly Leu Gln Asp Ala Phe Asp Ser Asp Trp Glu 
    850                 855                 860                 


Thr Gly Lys Ile Met Pro Asn Asn Tyr Lys Asn Gly Ser Asp Asp Gly 
865                 870                 875                 880 


Val Leu Ala Tyr Lys Leu Leu Val Gln Thr Gly Ser Arg Asp Lys Pro 
                885                 890                 895     


Ile Asp Ile Ser Gln Leu Thr Lys Gln Arg Leu Val Asp Ala Asp Gly 
            900                 905                 910         


Ile Ile Asn Pro Ser Ala Phe Tyr Ile Tyr Leu Thr Ala Trp Val Ser 
        915                 920                 925             


Asn Asp Pro Val Ala Tyr Ala Ala Ser Gln Ala Asn Ile Arg Pro His 
    930                 935                 940                 


Arg Pro Glu Trp Val His Asp Lys Ala Asp Tyr Met Pro Glu Thr Arg 
945                 950                 955                 960 


Leu Arg Ile Pro Ala Ala Glu Pro Ile Glu Tyr Ala Gln Phe Pro Phe 
                965                 970                 975     


Tyr Leu Asn Gly Leu Arg Asp Thr Ser Asp Phe Val Glu Ala Ile Glu 
            980                 985                 990         


Lys Val Arg Thr Ile Cys Ser Asn  Tyr Thr Ser Leu Gly  Leu Ser Ser 
        995                 1000                 1005             


Tyr Pro  Asn Gly Tyr Pro Phe  Leu Phe Trp Glu Gln  Tyr Ile Gly 
    1010                 1015                 1020             


Leu Arg  His Trp Leu Leu Leu  Phe Ile Ser Val Val  Leu Ala Cys 
    1025                 1030                 1035             


Thr Phe  Leu Val Cys Ala Val  Phe Leu Leu Asn Pro  Trp Thr Ala 
    1040                 1045                 1050             


Gly Ile  Ile Val Met Val Leu  Ala Leu Met Thr Val  Glu Leu Phe 
    1055                 1060                 1065             


Gly Met  Met Gly Leu Ile Gly  Ile Lys Leu Ser Ala  Val Pro Val 
    1070                 1075                 1080             


Val Ile  Leu Ile Ala Ser Val  Gly Ile Gly Val Glu  Phe Thr Val 
    1085                 1090                 1095             


His Val  Ala Leu Ala Phe Leu  Thr Ala Ile Gly Asp  Lys Asn Arg 
    1100                 1105                 1110             


Arg Ala  Val Leu Ala Leu Glu  His Met Phe Ala Pro  Val Leu Asp 
    1115                 1120                 1125             


Gly Ala  Val Ser Thr Leu Leu  Gly Val Leu Met Leu  Ala Gly Ser 
    1130                 1135                 1140             


Glu Phe  Asp Phe Ile Val Arg  Tyr Phe Phe Ala Val  Leu Ala Ile 
    1145                 1150                 1155             


Leu Thr  Ile Leu Gly Val Leu  Asn Gly Leu Val Leu  Leu Pro Val 
    1160                 1165                 1170             


Leu Leu  Ser Phe Phe Gly Pro  Tyr Pro Glu Val Ser  Pro Ala Asn 
    1175                 1180                 1185             


Gly Leu  Asn Arg Leu Pro Thr  Pro Ser Pro Glu Pro  Pro Pro Ser 
    1190                 1195                 1200             


Val Val  Arg Phe Ala Met Pro  Pro Gly His Thr His  Ser Gly Ser 
    1205                 1210                 1215             


Asp Ser  Ser Asp Ser Glu Tyr  Ser Ser Gln Thr Thr  Val Ser Gly 
    1220                 1225                 1230             


Leu Ser  Glu Glu Leu Arg His  Tyr Glu Ala Gln Gln  Gly Ala Gly 
    1235                 1240                 1245             


Gly Pro  Ala His Gln Val Ile  Val Glu Ala Thr Glu  Asn Pro Val 
    1250                 1255                 1260             


Phe Ala  His Ser Thr Val Val  His Pro Glu Ser Arg  His His Pro 
    1265                 1270                 1275             


Pro Ser  Asn Pro Arg Gln Gln  Pro His Leu Asp Ser  Gly Ser Leu 
    1280                 1285                 1290             


Pro Pro  Gly Arg Gln Gly Gln  Gln Pro Arg Arg Asp  Pro Pro Arg 
    1295                 1300                 1305             


Glu Gly  Leu Trp Pro Pro Pro  Tyr Arg Pro Arg Arg  Asp Ala Phe 
    1310                 1315                 1320             


Glu Ile  Ser Thr Glu Gly His  Ser Gly Pro Ser Asn  Arg Ala Arg 
    1325                 1330                 1335             


Trp Gly  Pro Arg Gly Ala Arg  Ser His Asn Pro Arg  Asn Pro Ala 
    1340                 1345                 1350             


Ser Thr  Ala Met Gly Ser Ser  Val Pro Gly Tyr Cys  Gln Pro Ile 
    1355                 1360                 1365             


Thr Thr  Val Thr Ala Ser Ala  Ser Val Thr Val Ala  Val His Pro 
    1370                 1375                 1380             


Pro Pro  Val Pro Gly Pro Gly  Arg Asn Pro Arg Gly  Gly Leu Cys 
    1385                 1390                 1395             


Pro Gly  Tyr Pro Glu Thr Asp  His Gly Leu Phe Glu  Asp Pro His 
    1400                 1405                 1410             


Val Pro  Phe His Val Arg Cys  Glu Arg Arg Asp Ser  Lys Val Glu 
    1415                 1420                 1425             


Val Ile  Glu Leu Gln Asp Val  Glu Cys Glu Glu Arg  Pro Arg Gly 
    1430                 1435                 1440             


Ser Ser  Ser Asn 
    1445         


<210> 5
<211> 1446
<212> PRT
<213> Homo sapiens

<400> 5
Met Glu Leu Leu Asn Arg Asn Arg Leu Val Ile Val Ser Pro Arg Cys 
1               5                   10                  15      


Thr Pro Pro Lys Ala Ser Gly Gly Pro Ala Arg Arg Gly Phe Tyr Thr 
            20                  25                  30          


Phe Arg Ser Phe Cys Lys Asp Gly Gly Gly Gly Glu Glu Glu Glu Glu 
        35                  40                  45              


Asn Gly Gly Glu Glu Lys Asp Asp Arg Gly Asp Lys Glu Thr Arg Ser 
    50                  55                  60                  


Asp Lys Gly Lys Ala Thr Gly Arg Lys Ala Pro Leu Trp Leu Arg Ala 
65                  70                  75                  80  


Lys Phe Gln Arg Leu Leu Phe Lys Leu Gly Cys Tyr Ile Gln Lys Asn 
                85                  90                  95      


Cys Gly Lys Phe Leu Val Val Gly Leu Leu Ile Phe Gly Ala Phe Ala 
            100                 105                 110         


Val Gly Leu Lys Ala Ala Asn Leu Glu Thr Asn Val Glu Glu Leu Trp 
        115                 120                 125             


Val Glu Val Gly Gly Arg Val Ser Arg Glu Leu Asn Tyr Thr Arg Gln 
    130                 135                 140                 


Lys Ile Gly Glu Glu Ala Met Phe Asn Pro Gln Leu Met Ile Gln Thr 
145                 150                 155                 160 


Pro Lys Glu Glu Gly Ala Asn Val Leu Thr Thr Glu Ala Leu Leu Gln 
                165                 170                 175     


His Leu Asp Ser Ala Leu Gln Ala Ser Arg Val His Val Tyr Met Tyr 
            180                 185                 190         


Asn Arg Gln Trp Lys Leu Glu His Leu Cys Tyr Lys Ser Gly Glu Leu 
        195                 200                 205             


Ile Thr Glu Thr Gly Tyr Met Asp Gln Ile Ile Glu Tyr Leu Tyr Pro 
    210                 215                 220                 


Cys Leu Ile Ile Thr Pro Leu Asp Cys Phe Trp Glu Gly Ala Lys Leu 
225                 230                 235                 240 


Gln Ser Gly Thr Ala Tyr Leu Leu Gly Lys Pro Pro Leu Arg Trp Thr 
                245                 250                 255     


Asn Phe Asp Pro Leu Glu Phe Leu Glu Glu Leu Lys Lys Ile Asn Tyr 
            260                 265                 270         


Gln Val Asp Ser Trp Glu Glu Met Leu Asn Lys Ala Glu Val Gly His 
        275                 280                 285             


Gly Tyr Met Asp Arg Pro Cys Leu Asn Pro Ala Asp Pro Asp Cys Pro 
    290                 295                 300                 


Ala Thr Ala Pro Asn Lys Asn Ser Thr Lys Pro Leu Asp Met Ala Leu 
305                 310                 315                 320 


Val Leu Asn Gly Gly Cys His Gly Leu Ser Arg Lys Tyr Met His Trp 
                325                 330                 335     


Gln Glu Glu Leu Ile Val Gly Gly Thr Val Lys Asn Ser Thr Gly Lys 
            340                 345                 350         


Leu Val Ser Ala His Ala Leu Gln Thr Met Phe Gln Leu Met Thr Pro 
        355                 360                 365             


Lys Gln Met Tyr Glu His Phe Lys Gly Tyr Glu Tyr Val Ser His Ile 
    370                 375                 380                 


Asn Trp Asn Glu Asp Lys Ala Ala Ala Ile Leu Glu Ala Trp Gln Arg 
385                 390                 395                 400 


Thr Tyr Val Glu Val Val His Gln Ser Val Ala Gln Asn Ser Thr Gln 
                405                 410                 415     


Lys Val Leu Ser Phe Thr Thr Thr Thr Leu Asp Asp Ile Leu Lys Ser 
            420                 425                 430         


Phe Ser Asp Val Ser Val Ile Arg Val Ala Ser Gly Tyr Leu Leu Met 
        435                 440                 445             


Leu Ala Tyr Ala Cys Leu Thr Met Leu Arg Trp Asp Cys Ser Lys Ser 
    450                 455                 460                 


Gln Gly Ala Val Gly Leu Ala Gly Val Leu Leu Val Ala Leu Ser Val 
465                 470                 475                 480 


Ala Ala Gly Leu Gly Leu Cys Ser Leu Ile Gly Ile Ser Phe Asn Ala 
                485                 490                 495     


Ala Thr Thr Gln Val Leu Pro Phe Leu Ala Leu Gly Val Gly Val Asp 
            500                 505                 510         


Asp Val Phe Leu Leu Ala His Ala Phe Ser Glu Thr Gly Gln Asn Lys 
        515                 520                 525             


Arg Ile Pro Phe Glu Asp Arg Thr Gly Glu Cys Leu Lys Arg Thr Gly 
    530                 535                 540                 


Ala Ser Val Ala Leu Thr Ser Ile Ser Asn Val Thr Ala Phe Phe Met 
545                 550                 555                 560 


Ala Ala Leu Ile Pro Ile Pro Ala Leu Arg Ala Phe Ser Leu Gln Ala 
                565                 570                 575     


Ala Val Val Val Val Phe Asn Phe Ala Met Val Leu Leu Ile Phe Pro 
            580                 585                 590         


Ala Ile Leu Ser Met Asp Leu Tyr Arg Arg Glu Asp Arg Arg Leu Asp 
        595                 600                 605             


Ile Phe Cys Cys Phe Thr Ser Pro Cys Val Ser Arg Val Ile Gln Val 
    610                 615                 620                 


Glu Pro Gln Ala Tyr Thr Asp Thr His Asp Asn Thr Arg Tyr Ser Pro 
625                 630                 635                 640 


Pro Pro Pro Tyr Ser Ser His Ser Phe Ala His Glu Thr Gln Ile Thr 
                645                 650                 655     


Met Gln Ser Thr Val Gln Leu Arg Thr Glu Tyr Asp Pro His Thr His 
            660                 665                 670         


Val Tyr Tyr Thr Thr Ala Glu Pro Arg Ser Glu Ile Ser Val Gln Pro 
        675                 680                 685             


Val Thr Val Thr Gln Asp Thr Leu Ser Cys Gln Ser Pro Glu Ser Thr 
    690                 695                 700                 


Ser Ser Thr Arg Asp Leu Leu Ser Gln Phe Ser Asp Ser Ser Leu His 
705                 710                 715                 720 


Cys Leu Glu Pro Pro Cys Thr Lys Trp Thr Leu Ser Ser Phe Ala Glu 
                725                 730                 735     


Lys His Tyr Ala Pro Phe Leu Leu Lys Pro Lys Ala Lys Val Val Val 
            740                 745                 750         


Ile Phe Leu Phe Leu Gly Leu Leu Gly Val Ser Leu Tyr Gly Thr Thr 
        755                 760                 765             


Arg Val Arg Asp Gly Leu Asp Leu Thr Asp Ile Val Pro Arg Glu Thr 
    770                 775                 780                 


Arg Glu Tyr Asp Phe Ile Ala Ala Gln Phe Lys Tyr Phe Ser Phe Tyr 
785                 790                 795                 800 


Asn Met Tyr Ile Val Thr Gln Lys Ala Asp Tyr Pro Asn Ile Gln His 
                805                 810                 815     


Leu Leu Tyr Asp Leu His Arg Ser Phe Ser Asn Val Lys Tyr Val Met 
            820                 825                 830         


Leu Glu Glu Asn Lys Gln Leu Pro Lys Met Trp Leu His Tyr Phe Arg 
        835                 840                 845             


Asp Trp Leu Gln Gly Leu Gln Asp Ala Phe Asp Ser Asp Trp Glu Thr 
    850                 855                 860                 


Gly Lys Ile Met Pro Asn Asn Tyr Lys Asn Gly Ser Asp Asp Gly Val 
865                 870                 875                 880 


Leu Ala Tyr Lys Leu Leu Val Gln Thr Gly Ser Arg Asp Lys Pro Ile 
                885                 890                 895     


Asp Ile Ser Gln Leu Thr Lys Gln Arg Leu Val Asp Ala Asp Gly Ile 
            900                 905                 910         


Ile Asn Pro Ser Ala Phe Tyr Ile Tyr Leu Thr Ala Trp Val Ser Asn 
        915                 920                 925             


Asp Pro Val Ala Tyr Ala Ala Ser Gln Ala Asn Ile Arg Pro His Arg 
    930                 935                 940                 


Pro Glu Trp Val His Asp Lys Ala Asp Tyr Met Pro Glu Thr Arg Leu 
945                 950                 955                 960 


Arg Ile Pro Ala Ala Glu Pro Ile Glu Tyr Ala Gln Phe Pro Phe Tyr 
                965                 970                 975     


Leu Asn Gly Leu Arg Asp Thr Ser Asp Phe Val Glu Ala Ile Glu Lys 
            980                 985                 990         


Val Arg Thr Ile Cys Ser Asn Tyr  Thr Ser Leu Gly Leu  Ser Ser Tyr 
        995                 1000                 1005             


Pro Asn  Gly Tyr Pro Phe Leu  Phe Trp Glu Gln Tyr  Ile Gly Leu 
    1010                 1015                 1020             


Arg His  Trp Leu Leu Leu Phe  Ile Ser Val Val Leu  Ala Cys Thr 
    1025                 1030                 1035             


Phe Leu  Val Cys Ala Val Phe  Leu Leu Asn Pro Trp  Thr Ala Gly 
    1040                 1045                 1050             


Ile Ile  Val Met Val Leu Ala  Leu Met Thr Val Glu  Leu Phe Gly 
    1055                 1060                 1065             


Met Met  Gly Leu Ile Gly Ile  Lys Leu Ser Ala Val  Pro Val Val 
    1070                 1075                 1080             


Ile Leu  Ile Ala Ser Val Gly  Ile Gly Val Glu Phe  Thr Val His 
    1085                 1090                 1095             


Val Ala  Leu Ala Phe Leu Thr  Ala Ile Gly Asp Lys  Asn Arg Arg 
    1100                 1105                 1110             


Ala Val  Leu Ala Leu Glu His  Met Phe Ala Pro Val  Leu Asp Gly 
    1115                 1120                 1125             


Ala Val  Ser Thr Leu Leu Gly  Val Leu Met Leu Ala  Gly Ser Glu 
    1130                 1135                 1140             


Phe Asp  Phe Ile Val Arg Tyr  Phe Phe Ala Val Leu  Ala Ile Leu 
    1145                 1150                 1155             


Thr Ile  Leu Gly Val Leu Asn  Gly Leu Val Leu Leu  Pro Val Leu 
    1160                 1165                 1170             


Leu Ser  Phe Phe Gly Pro Tyr  Pro Glu Val Ser Pro  Ala Asn Gly 
    1175                 1180                 1185             


Leu Asn  Arg Leu Pro Thr Pro  Ser Pro Glu Pro Pro  Pro Ser Val 
    1190                 1195                 1200             


Val Arg  Phe Ala Met Pro Pro  Gly His Thr His Ser  Gly Ser Asp 
    1205                 1210                 1215             


Ser Ser  Asp Ser Glu Tyr Ser  Ser Gln Thr Thr Val  Ser Gly Leu 
    1220                 1225                 1230             


Ser Glu  Glu Leu Arg His Tyr  Glu Ala Gln Gln Gly  Ala Gly Gly 
    1235                 1240                 1245             


Pro Ala  His Gln Val Ile Val  Glu Ala Thr Glu Asn  Pro Val Phe 
    1250                 1255                 1260             


Ala His  Ser Thr Val Val His  Pro Glu Ser Arg His  His Pro Pro 
    1265                 1270                 1275             


Ser Asn  Pro Arg Gln Gln Pro  His Leu Asp Ser Gly  Ser Leu Pro 
    1280                 1285                 1290             


Pro Gly  Arg Gln Gly Gln Gln  Pro Arg Arg Asp Pro  Pro Arg Glu 
    1295                 1300                 1305             


Gly Leu  Trp Pro Pro Pro Tyr  Arg Pro Arg Arg Asp  Ala Phe Glu 
    1310                 1315                 1320             


Ile Ser  Thr Glu Gly His Ser  Gly Pro Ser Asn Arg  Ala Arg Trp 
    1325                 1330                 1335             


Gly Pro  Arg Gly Ala Arg Ser  His Asn Pro Arg Asn  Pro Ala Ser 
    1340                 1345                 1350             


Thr Ala  Met Gly Ser Ser Val  Pro Gly Tyr Cys Gln  Pro Ile Thr 
    1355                 1360                 1365             


Thr Val  Thr Ala Ser Ala Ser  Val Thr Val Ala Val  His Pro Pro 
    1370                 1375                 1380             


Pro Val  Pro Gly Pro Gly Arg  Asn Pro Arg Gly Gly  Leu Cys Pro 
    1385                 1390                 1395             


Gly Tyr  Pro Glu Thr Asp His  Gly Leu Phe Glu Asp  Pro His Val 
    1400                 1405                 1410             


Pro Phe  His Val Arg Cys Glu  Arg Arg Asp Ser Lys  Val Glu Val 
    1415                 1420                 1425             


Ile Glu  Leu Gln Asp Val Glu  Cys Glu Glu Arg Pro  Arg Gly Ser 
    1430                 1435                 1440             


Ser Ser  Asn 
    1445     


<210> 6
<211> 1381
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Lys Ala Thr Gly Arg Lys Ala Pro Leu Trp Leu Arg Ala Lys 
1               5                   10                  15      


Phe Gln Arg Leu Leu Phe Lys Leu Gly Cys Tyr Ile Gln Lys Asn Cys 
            20                  25                  30          


Gly Lys Phe Leu Val Val Gly Leu Leu Ile Phe Gly Ala Phe Ala Val 
        35                  40                  45              


Gly Leu Lys Ala Ala Asn Leu Glu Thr Asn Val Glu Glu Leu Trp Val 
    50                  55                  60                  


Glu Val Gly Gly Arg Val Ser Arg Glu Leu Asn Tyr Thr Arg Gln Lys 
65                  70                  75                  80  


Ile Gly Glu Glu Ala Met Phe Asn Pro Gln Leu Met Ile Gln Thr Pro 
                85                  90                  95      


Lys Glu Glu Gly Ala Asn Val Leu Thr Thr Glu Ala Leu Leu Gln His 
            100                 105                 110         


Leu Asp Ser Ala Leu Gln Ala Ser Arg Val His Val Tyr Met Tyr Asn 
        115                 120                 125             


Arg Gln Trp Lys Leu Glu His Leu Cys Tyr Lys Ser Gly Glu Leu Ile 
    130                 135                 140                 


Thr Glu Thr Gly Tyr Met Asp Gln Ile Ile Glu Tyr Leu Tyr Pro Cys 
145                 150                 155                 160 


Leu Ile Ile Thr Pro Leu Asp Cys Phe Trp Glu Gly Ala Lys Leu Gln 
                165                 170                 175     


Ser Gly Thr Ala Tyr Leu Leu Gly Lys Pro Pro Leu Arg Trp Thr Asn 
            180                 185                 190         


Phe Asp Pro Leu Glu Phe Leu Glu Glu Leu Lys Lys Ile Asn Tyr Gln 
        195                 200                 205             


Val Asp Ser Trp Glu Glu Met Leu Asn Lys Ala Glu Val Gly His Gly 
    210                 215                 220                 


Tyr Met Asp Arg Pro Cys Leu Asn Pro Ala Asp Pro Asp Cys Pro Ala 
225                 230                 235                 240 


Thr Ala Pro Asn Lys Asn Ser Thr Lys Pro Leu Asp Met Ala Leu Val 
                245                 250                 255     


Leu Asn Gly Gly Cys His Gly Leu Ser Arg Lys Tyr Met His Trp Gln 
            260                 265                 270         


Glu Glu Leu Ile Val Gly Gly Thr Val Lys Asn Ser Thr Gly Lys Leu 
        275                 280                 285             


Val Ser Ala His Ala Leu Gln Thr Met Phe Gln Leu Met Thr Pro Lys 
    290                 295                 300                 


Gln Met Tyr Glu His Phe Lys Gly Tyr Glu Tyr Val Ser His Ile Asn 
305                 310                 315                 320 


Trp Asn Glu Asp Lys Ala Ala Ala Ile Leu Glu Ala Trp Gln Arg Thr 
                325                 330                 335     


Tyr Val Glu Val Val His Gln Ser Val Ala Gln Asn Ser Thr Gln Lys 
            340                 345                 350         


Val Leu Ser Phe Thr Thr Thr Thr Leu Asp Asp Ile Leu Lys Ser Phe 
        355                 360                 365             


Ser Asp Val Ser Val Ile Arg Val Ala Ser Gly Tyr Leu Leu Met Leu 
    370                 375                 380                 


Ala Tyr Ala Cys Leu Thr Met Leu Arg Trp Asp Cys Ser Lys Ser Gln 
385                 390                 395                 400 


Gly Ala Val Gly Leu Ala Gly Val Leu Leu Val Ala Leu Ser Val Ala 
                405                 410                 415     


Ala Gly Leu Gly Leu Cys Ser Leu Ile Gly Ile Ser Phe Asn Ala Ala 
            420                 425                 430         


Thr Thr Gln Val Leu Pro Phe Leu Ala Leu Gly Val Gly Val Asp Asp 
        435                 440                 445             


Val Phe Leu Leu Ala His Ala Phe Ser Glu Thr Gly Gln Asn Lys Arg 
    450                 455                 460                 


Ile Pro Phe Glu Asp Arg Thr Gly Glu Cys Leu Lys Arg Thr Gly Ala 
465                 470                 475                 480 


Ser Val Ala Leu Thr Ser Ile Ser Asn Val Thr Ala Phe Phe Met Ala 
                485                 490                 495     


Ala Leu Ile Pro Ile Pro Ala Leu Arg Ala Phe Ser Leu Gln Ala Ala 
            500                 505                 510         


Val Val Val Val Phe Asn Phe Ala Met Val Leu Leu Ile Phe Pro Ala 
        515                 520                 525             


Ile Leu Ser Met Asp Leu Tyr Arg Arg Glu Asp Arg Arg Leu Asp Ile 
    530                 535                 540                 


Phe Cys Cys Phe Thr Ser Pro Cys Val Ser Arg Val Ile Gln Val Glu 
545                 550                 555                 560 


Pro Gln Ala Tyr Thr Asp Thr His Asp Asn Thr Arg Tyr Ser Pro Pro 
                565                 570                 575     


Pro Pro Tyr Ser Ser His Ser Phe Ala His Glu Thr Gln Ile Thr Met 
            580                 585                 590         


Gln Ser Thr Val Gln Leu Arg Thr Glu Tyr Asp Pro His Thr His Val 
        595                 600                 605             


Tyr Tyr Thr Thr Ala Glu Pro Arg Ser Glu Ile Ser Val Gln Pro Val 
    610                 615                 620                 


Thr Val Thr Gln Asp Thr Leu Ser Cys Gln Ser Pro Glu Ser Thr Ser 
625                 630                 635                 640 


Ser Thr Arg Asp Leu Leu Ser Gln Phe Ser Asp Ser Ser Leu His Cys 
                645                 650                 655     


Leu Glu Pro Pro Cys Thr Lys Trp Thr Leu Ser Ser Phe Ala Glu Lys 
            660                 665                 670         


His Tyr Ala Pro Phe Leu Leu Lys Pro Lys Ala Lys Val Val Val Ile 
        675                 680                 685             


Phe Leu Phe Leu Gly Leu Leu Gly Val Ser Leu Tyr Gly Thr Thr Arg 
    690                 695                 700                 


Val Arg Asp Gly Leu Asp Leu Thr Asp Ile Val Pro Arg Glu Thr Arg 
705                 710                 715                 720 


Glu Tyr Asp Phe Ile Ala Ala Gln Phe Lys Tyr Phe Ser Phe Tyr Asn 
                725                 730                 735     


Met Tyr Ile Val Thr Gln Lys Ala Asp Tyr Pro Asn Ile Gln His Leu 
            740                 745                 750         


Leu Tyr Asp Leu His Arg Ser Phe Ser Asn Val Lys Tyr Val Met Leu 
        755                 760                 765             


Glu Glu Asn Lys Gln Leu Pro Lys Met Trp Leu His Tyr Phe Arg Asp 
    770                 775                 780                 


Trp Leu Gln Gly Leu Gln Asp Ala Phe Asp Ser Asp Trp Glu Thr Gly 
785                 790                 795                 800 


Lys Ile Met Pro Asn Asn Tyr Lys Asn Gly Ser Asp Asp Gly Val Leu 
                805                 810                 815     


Ala Tyr Lys Leu Leu Val Gln Thr Gly Ser Arg Asp Lys Pro Ile Asp 
            820                 825                 830         


Ile Ser Gln Leu Thr Lys Gln Arg Leu Val Asp Ala Asp Gly Ile Ile 
        835                 840                 845             


Asn Pro Ser Ala Phe Tyr Ile Tyr Leu Thr Ala Trp Val Ser Asn Asp 
    850                 855                 860                 


Pro Val Ala Tyr Ala Ala Ser Gln Ala Asn Ile Arg Pro His Arg Pro 
865                 870                 875                 880 


Glu Trp Val His Asp Lys Ala Asp Tyr Met Pro Glu Thr Arg Leu Arg 
                885                 890                 895     


Ile Pro Ala Ala Glu Pro Ile Glu Tyr Ala Gln Phe Pro Phe Tyr Leu 
            900                 905                 910         


Asn Gly Leu Arg Asp Thr Ser Asp Phe Val Glu Ala Ile Glu Lys Val 
        915                 920                 925             


Arg Thr Ile Cys Ser Asn Tyr Thr Ser Leu Gly Leu Ser Ser Tyr Pro 
    930                 935                 940                 


Asn Gly Tyr Pro Phe Leu Phe Trp Glu Gln Tyr Ile Gly Leu Arg His 
945                 950                 955                 960 


Trp Leu Leu Leu Phe Ile Ser Val Val Leu Ala Cys Thr Phe Leu Val 
                965                 970                 975     


Cys Ala Val Phe Leu Leu Asn Pro Trp Thr Ala Gly Ile Ile Val Met 
            980                 985                 990         


Val Leu Ala Leu Met Thr Val Glu  Leu Phe Gly Met Met  Gly Leu Ile 
        995                 1000                 1005             


Gly Ile  Lys Leu Ser Ala Val  Pro Val Val Ile Leu  Ile Ala Ser 
    1010                 1015                 1020             


Val Gly  Ile Gly Val Glu Phe  Thr Val His Val Ala  Leu Ala Phe 
    1025                 1030                 1035             


Leu Thr  Ala Ile Gly Asp Lys  Asn Arg Arg Ala Val  Leu Ala Leu 
    1040                 1045                 1050             


Glu His  Met Phe Ala Pro Val  Leu Asp Gly Ala Val  Ser Thr Leu 
    1055                 1060                 1065             


Leu Gly  Val Leu Met Leu Ala  Gly Ser Glu Phe Asp  Phe Ile Val 
    1070                 1075                 1080             


Arg Tyr  Phe Phe Ala Val Leu  Ala Ile Leu Thr Ile  Leu Gly Val 
    1085                 1090                 1095             


Leu Asn  Gly Leu Val Leu Leu  Pro Val Leu Leu Ser  Phe Phe Gly 
    1100                 1105                 1110             


Pro Tyr  Pro Glu Val Ser Pro  Ala Asn Gly Leu Asn  Arg Leu Pro 
    1115                 1120                 1125             


Thr Pro  Ser Pro Glu Pro Pro  Pro Ser Val Val Arg  Phe Ala Met 
    1130                 1135                 1140             


Pro Pro  Gly His Thr His Ser  Gly Ser Asp Ser Ser  Asp Ser Glu 
    1145                 1150                 1155             


Tyr Ser  Ser Gln Thr Thr Val  Ser Gly Leu Ser Glu  Glu Leu Arg 
    1160                 1165                 1170             


His Tyr  Glu Ala Gln Gln Gly  Ala Gly Gly Pro Ala  His Gln Val 
    1175                 1180                 1185             


Ile Val  Glu Ala Thr Glu Asn  Pro Val Phe Ala His  Ser Thr Val 
    1190                 1195                 1200             


Val His  Pro Glu Ser Arg His  His Pro Pro Ser Asn  Pro Arg Gln 
    1205                 1210                 1215             


Gln Pro  His Leu Asp Ser Gly  Ser Leu Pro Pro Gly  Arg Gln Gly 
    1220                 1225                 1230             


Gln Gln  Pro Arg Arg Asp Pro  Pro Arg Glu Gly Leu  Trp Pro Pro 
    1235                 1240                 1245             


Pro Tyr  Arg Pro Arg Arg Asp  Ala Phe Glu Ile Ser  Thr Glu Gly 
    1250                 1255                 1260             


His Ser  Gly Pro Ser Asn Arg  Ala Arg Trp Gly Pro  Arg Gly Ala 
    1265                 1270                 1275             


Arg Ser  His Asn Pro Arg Asn  Pro Ala Ser Thr Ala  Met Gly Ser 
    1280                 1285                 1290             


Ser Val  Pro Gly Tyr Cys Gln  Pro Ile Thr Thr Val  Thr Ala Ser 
    1295                 1300                 1305             


Ala Ser  Val Thr Val Ala Val  His Pro Pro Pro Val  Pro Gly Pro 
    1310                 1315                 1320             


Gly Arg  Asn Pro Arg Gly Gly  Leu Cys Pro Gly Tyr  Pro Glu Thr 
    1325                 1330                 1335             


Asp His  Gly Leu Phe Glu Asp  Pro His Val Pro Phe  His Val Arg 
    1340                 1345                 1350             


Cys Glu  Arg Arg Asp Ser Lys  Val Glu Val Ile Glu  Leu Gln Asp 
    1355                 1360                 1365             


Val Glu  Cys Glu Glu Arg Pro  Arg Gly Ser Ser Ser  Asn 
    1370                 1375                 1380     


<210> 7
<211> 1296
<212> PRT
<213> Homo sapiens

<400> 7
Met Phe Asn Pro Gln Leu Met Ile Gln Thr Pro Lys Glu Glu Gly Ala 
1               5                   10                  15      


Asn Val Leu Thr Thr Glu Ala Leu Leu Gln His Leu Asp Ser Ala Leu 
            20                  25                  30          


Gln Ala Ser Arg Val His Val Tyr Met Tyr Asn Arg Gln Trp Lys Leu 
        35                  40                  45              


Glu His Leu Cys Tyr Lys Ser Gly Glu Leu Ile Thr Glu Thr Gly Tyr 
    50                  55                  60                  


Met Asp Gln Ile Ile Glu Tyr Leu Tyr Pro Cys Leu Ile Ile Thr Pro 
65                  70                  75                  80  


Leu Asp Cys Phe Trp Glu Gly Ala Lys Leu Gln Ser Gly Thr Ala Tyr 
                85                  90                  95      


Leu Leu Gly Lys Pro Pro Leu Arg Trp Thr Asn Phe Asp Pro Leu Glu 
            100                 105                 110         


Phe Leu Glu Glu Leu Lys Lys Ile Asn Tyr Gln Val Asp Ser Trp Glu 
        115                 120                 125             


Glu Met Leu Asn Lys Ala Glu Val Gly His Gly Tyr Met Asp Arg Pro 
    130                 135                 140                 


Cys Leu Asn Pro Ala Asp Pro Asp Cys Pro Ala Thr Ala Pro Asn Lys 
145                 150                 155                 160 


Asn Ser Thr Lys Pro Leu Asp Met Ala Leu Val Leu Asn Gly Gly Cys 
                165                 170                 175     


His Gly Leu Ser Arg Lys Tyr Met His Trp Gln Glu Glu Leu Ile Val 
            180                 185                 190         


Gly Gly Thr Val Lys Asn Ser Thr Gly Lys Leu Val Ser Ala His Ala 
        195                 200                 205             


Leu Gln Thr Met Phe Gln Leu Met Thr Pro Lys Gln Met Tyr Glu His 
    210                 215                 220                 


Phe Lys Gly Tyr Glu Tyr Val Ser His Ile Asn Trp Asn Glu Asp Lys 
225                 230                 235                 240 


Ala Ala Ala Ile Leu Glu Ala Trp Gln Arg Thr Tyr Val Glu Val Val 
                245                 250                 255     


His Gln Ser Val Ala Gln Asn Ser Thr Gln Lys Val Leu Ser Phe Thr 
            260                 265                 270         


Thr Thr Thr Leu Asp Asp Ile Leu Lys Ser Phe Ser Asp Val Ser Val 
        275                 280                 285             


Ile Arg Val Ala Ser Gly Tyr Leu Leu Met Leu Ala Tyr Ala Cys Leu 
    290                 295                 300                 


Thr Met Leu Arg Trp Asp Cys Ser Lys Ser Gln Gly Ala Val Gly Leu 
305                 310                 315                 320 


Ala Gly Val Leu Leu Val Ala Leu Ser Val Ala Ala Gly Leu Gly Leu 
                325                 330                 335     


Cys Ser Leu Ile Gly Ile Ser Phe Asn Ala Ala Thr Thr Gln Val Leu 
            340                 345                 350         


Pro Phe Leu Ala Leu Gly Val Gly Val Asp Asp Val Phe Leu Leu Ala 
        355                 360                 365             


His Ala Phe Ser Glu Thr Gly Gln Asn Lys Arg Ile Pro Phe Glu Asp 
    370                 375                 380                 


Arg Thr Gly Glu Cys Leu Lys Arg Thr Gly Ala Ser Val Ala Leu Thr 
385                 390                 395                 400 


Ser Ile Ser Asn Val Thr Ala Phe Phe Met Ala Ala Leu Ile Pro Ile 
                405                 410                 415     


Pro Ala Leu Arg Ala Phe Ser Leu Gln Ala Ala Val Val Val Val Phe 
            420                 425                 430         


Asn Phe Ala Met Val Leu Leu Ile Phe Pro Ala Ile Leu Ser Met Asp 
        435                 440                 445             


Leu Tyr Arg Arg Glu Asp Arg Arg Leu Asp Ile Phe Cys Cys Phe Thr 
    450                 455                 460                 


Ser Pro Cys Val Ser Arg Val Ile Gln Val Glu Pro Gln Ala Tyr Thr 
465                 470                 475                 480 


Asp Thr His Asp Asn Thr Arg Tyr Ser Pro Pro Pro Pro Tyr Ser Ser 
                485                 490                 495     


His Ser Phe Ala His Glu Thr Gln Ile Thr Met Gln Ser Thr Val Gln 
            500                 505                 510         


Leu Arg Thr Glu Tyr Asp Pro His Thr His Val Tyr Tyr Thr Thr Ala 
        515                 520                 525             


Glu Pro Arg Ser Glu Ile Ser Val Gln Pro Val Thr Val Thr Gln Asp 
    530                 535                 540                 


Thr Leu Ser Cys Gln Ser Pro Glu Ser Thr Ser Ser Thr Arg Asp Leu 
545                 550                 555                 560 


Leu Ser Gln Phe Ser Asp Ser Ser Leu His Cys Leu Glu Pro Pro Cys 
                565                 570                 575     


Thr Lys Trp Thr Leu Ser Ser Phe Ala Glu Lys His Tyr Ala Pro Phe 
            580                 585                 590         


Leu Leu Lys Pro Lys Ala Lys Val Val Val Ile Phe Leu Phe Leu Gly 
        595                 600                 605             


Leu Leu Gly Val Ser Leu Tyr Gly Thr Thr Arg Val Arg Asp Gly Leu 
    610                 615                 620                 


Asp Leu Thr Asp Ile Val Pro Arg Glu Thr Arg Glu Tyr Asp Phe Ile 
625                 630                 635                 640 


Ala Ala Gln Phe Lys Tyr Phe Ser Phe Tyr Asn Met Tyr Ile Val Thr 
                645                 650                 655     


Gln Lys Ala Asp Tyr Pro Asn Ile Gln His Leu Leu Tyr Asp Leu His 
            660                 665                 670         


Arg Ser Phe Ser Asn Val Lys Tyr Val Met Leu Glu Glu Asn Lys Gln 
        675                 680                 685             


Leu Pro Lys Met Trp Leu His Tyr Phe Arg Asp Trp Leu Gln Gly Leu 
    690                 695                 700                 


Gln Asp Ala Phe Asp Ser Asp Trp Glu Thr Gly Lys Ile Met Pro Asn 
705                 710                 715                 720 


Asn Tyr Lys Asn Gly Ser Asp Asp Gly Val Leu Ala Tyr Lys Leu Leu 
                725                 730                 735     


Val Gln Thr Gly Ser Arg Asp Lys Pro Ile Asp Ile Ser Gln Leu Thr 
            740                 745                 750         


Lys Gln Arg Leu Val Asp Ala Asp Gly Ile Ile Asn Pro Ser Ala Phe 
        755                 760                 765             


Tyr Ile Tyr Leu Thr Ala Trp Val Ser Asn Asp Pro Val Ala Tyr Ala 
    770                 775                 780                 


Ala Ser Gln Ala Asn Ile Arg Pro His Arg Pro Glu Trp Val His Asp 
785                 790                 795                 800 


Lys Ala Asp Tyr Met Pro Glu Thr Arg Leu Arg Ile Pro Ala Ala Glu 
                805                 810                 815     


Pro Ile Glu Tyr Ala Gln Phe Pro Phe Tyr Leu Asn Gly Leu Arg Asp 
            820                 825                 830         


Thr Ser Asp Phe Val Glu Ala Ile Glu Lys Val Arg Thr Ile Cys Ser 
        835                 840                 845             


Asn Tyr Thr Ser Leu Gly Leu Ser Ser Tyr Pro Asn Gly Tyr Pro Phe 
    850                 855                 860                 


Leu Phe Trp Glu Gln Tyr Ile Gly Leu Arg His Trp Leu Leu Leu Phe 
865                 870                 875                 880 


Ile Ser Val Val Leu Ala Cys Thr Phe Leu Val Cys Ala Val Phe Leu 
                885                 890                 895     


Leu Asn Pro Trp Thr Ala Gly Ile Ile Val Met Val Leu Ala Leu Met 
            900                 905                 910         


Thr Val Glu Leu Phe Gly Met Met Gly Leu Ile Gly Ile Lys Leu Ser 
        915                 920                 925             


Ala Val Pro Val Val Ile Leu Ile Ala Ser Val Gly Ile Gly Val Glu 
    930                 935                 940                 


Phe Thr Val His Val Ala Leu Ala Phe Leu Thr Ala Ile Gly Asp Lys 
945                 950                 955                 960 


Asn Arg Arg Ala Val Leu Ala Leu Glu His Met Phe Ala Pro Val Leu 
                965                 970                 975     


Asp Gly Ala Val Ser Thr Leu Leu Gly Val Leu Met Leu Ala Gly Ser 
            980                 985                 990         


Glu Phe Asp Phe Ile Val Arg Tyr  Phe Phe Ala Val Leu  Ala Ile Leu 
        995                 1000                 1005             


Thr Ile  Leu Gly Val Leu Asn  Gly Leu Val Leu Leu  Pro Val Leu 
    1010                 1015                 1020             


Leu Ser  Phe Phe Gly Pro Tyr  Pro Glu Val Ser Pro  Ala Asn Gly 
    1025                 1030                 1035             


Leu Asn  Arg Leu Pro Thr Pro  Ser Pro Glu Pro Pro  Pro Ser Val 
    1040                 1045                 1050             


Val Arg  Phe Ala Met Pro Pro  Gly His Thr His Ser  Gly Ser Asp 
    1055                 1060                 1065             


Ser Ser  Asp Ser Glu Tyr Ser  Ser Gln Thr Thr Val  Ser Gly Leu 
    1070                 1075                 1080             


Ser Glu  Glu Leu Arg His Tyr  Glu Ala Gln Gln Gly  Ala Gly Gly 
    1085                 1090                 1095             


Pro Ala  His Gln Val Ile Val  Glu Ala Thr Glu Asn  Pro Val Phe 
    1100                 1105                 1110             


Ala His  Ser Thr Val Val His  Pro Glu Ser Arg His  His Pro Pro 
    1115                 1120                 1125             


Ser Asn  Pro Arg Gln Gln Pro  His Leu Asp Ser Gly  Ser Leu Pro 
    1130                 1135                 1140             


Pro Gly  Arg Gln Gly Gln Gln  Pro Arg Arg Asp Pro  Pro Arg Glu 
    1145                 1150                 1155             


Gly Leu  Trp Pro Pro Pro Tyr  Arg Pro Arg Arg Asp  Ala Phe Glu 
    1160                 1165                 1170             


Ile Ser  Thr Glu Gly His Ser  Gly Pro Ser Asn Arg  Ala Arg Trp 
    1175                 1180                 1185             


Gly Pro  Arg Gly Ala Arg Ser  His Asn Pro Arg Asn  Pro Ala Ser 
    1190                 1195                 1200             


Thr Ala  Met Gly Ser Ser Val  Pro Gly Tyr Cys Gln  Pro Ile Thr 
    1205                 1210                 1215             


Thr Val  Thr Ala Ser Ala Ser  Val Thr Val Ala Val  His Pro Pro 
    1220                 1225                 1230             


Pro Val  Pro Gly Pro Gly Arg  Asn Pro Arg Gly Gly  Leu Cys Pro 
    1235                 1240                 1245             


Gly Tyr  Pro Glu Thr Asp His  Gly Leu Phe Glu Asp  Pro His Val 
    1250                 1255                 1260             


Pro Phe  His Val Arg Cys Glu  Arg Arg Asp Ser Lys  Val Glu Val 
    1265                 1270                 1275             


Ile Glu  Leu Gln Asp Val Glu  Cys Glu Glu Arg Pro  Arg Gly Ser 
    1280                 1285                 1290             


Ser Ser  Asn 
    1295     


<210> 8
<211> 1203
<212> PRT
<213> Homo sapiens

<400> 8
Met Thr Arg Ser Pro Pro Leu Arg Glu Leu Pro Pro Ser Tyr Thr Pro 
1               5                   10                  15      


Pro Ala Arg Thr Ala Ala Pro Gln Ile Leu Ala Gly Ser Leu Lys Ala 
            20                  25                  30          


Pro Leu Trp Leu Arg Ala Tyr Phe Gln Gly Leu Leu Phe Ser Leu Gly 
        35                  40                  45              


Cys Gly Ile Gln Arg His Cys Gly Lys Val Leu Phe Leu Gly Leu Leu 
    50                  55                  60                  


Ala Phe Gly Ala Leu Ala Leu Gly Leu Arg Met Ala Ile Ile Glu Thr 
65                  70                  75                  80  


Asn Leu Glu Gln Leu Trp Val Glu Val Gly Ser Arg Val Ser Gln Glu 
                85                  90                  95      


Leu His Tyr Thr Lys Glu Lys Leu Gly Glu Glu Ala Ala Tyr Thr Ser 
            100                 105                 110         


Gln Met Leu Ile Gln Thr Ala Arg Gln Glu Gly Glu Asn Ile Leu Thr 
        115                 120                 125             


Pro Glu Ala Leu Gly Leu His Leu Gln Ala Ala Leu Thr Ala Ser Lys 
    130                 135                 140                 


Val Gln Val Ser Leu Tyr Gly Lys Ser Trp Asp Leu Asn Lys Ile Cys 
145                 150                 155                 160 


Tyr Lys Ser Gly Val Pro Leu Ile Glu Asn Gly Met Ile Glu Arg Met 
                165                 170                 175     


Ile Glu Lys Leu Phe Pro Cys Val Ile Leu Thr Pro Leu Asp Cys Phe 
            180                 185                 190         


Trp Glu Gly Ala Lys Leu Gln Gly Gly Ser Ala Tyr Leu Pro Gly Arg 
        195                 200                 205             


Pro Asp Ile Gln Trp Thr Asn Leu Asp Pro Glu Gln Leu Leu Glu Glu 
    210                 215                 220                 


Leu Gly Pro Phe Ala Ser Leu Glu Gly Phe Arg Glu Leu Leu Asp Lys 
225                 230                 235                 240 


Ala Gln Val Gly Gln Ala Tyr Val Gly Arg Pro Cys Leu His Pro Asp 
                245                 250                 255     


Asp Leu His Cys Pro Pro Ser Ala Pro Asn His His Ser Arg Gln Ala 
            260                 265                 270         


Pro Asn Val Ala His Glu Leu Ser Gly Gly Cys His Gly Phe Ser His 
        275                 280                 285             


Lys Phe Met His Trp Gln Glu Glu Leu Leu Leu Gly Gly Met Ala Arg 
    290                 295                 300                 


Asp Pro Gln Gly Glu Leu Leu Arg Ala Glu Ala Leu Gln Ser Thr Phe 
305                 310                 315                 320 


Leu Leu Met Ser Pro Arg Gln Leu Tyr Glu His Phe Arg Gly Asp Tyr 
                325                 330                 335     


Gln Thr His Asp Ile Gly Trp Ser Glu Glu Gln Ala Ser Thr Val Leu 
            340                 345                 350         


Gln Ala Trp Gln Arg Arg Phe Val Gln Leu Ala Gln Glu Ala Leu Pro 
        355                 360                 365             


Glu Asn Ala Ser Gln Gln Ile His Ala Phe Ser Ser Thr Thr Leu Asp 
    370                 375                 380                 


Asp Ile Leu His Ala Phe Ser Glu Val Ser Ala Ala Arg Val Val Gly 
385                 390                 395                 400 


Gly Tyr Leu Leu Met Leu Ala Tyr Ala Cys Val Thr Met Leu Arg Trp 
                405                 410                 415     


Asp Cys Ala Gln Ser Gln Gly Ser Val Gly Leu Ala Gly Val Leu Leu 
            420                 425                 430         


Val Ala Leu Ala Val Ala Ser Gly Leu Gly Leu Cys Ala Leu Leu Gly 
        435                 440                 445             


Ile Thr Phe Asn Ala Ala Thr Thr Gln Val Leu Pro Phe Leu Ala Leu 
    450                 455                 460                 


Gly Ile Gly Val Asp Asp Val Phe Leu Leu Ala His Ala Phe Thr Glu 
465                 470                 475                 480 


Ala Leu Pro Gly Thr Pro Leu Gln Glu Arg Met Gly Glu Cys Leu Gln 
                485                 490                 495     


Arg Thr Gly Thr Ser Val Val Leu Thr Ser Ile Asn Asn Met Ala Ala 
            500                 505                 510         


Phe Leu Met Ala Ala Leu Val Pro Ile Pro Ala Leu Arg Ala Phe Ser 
        515                 520                 525             


Leu Gln Ala Ala Ile Val Val Gly Cys Thr Phe Val Ala Val Met Leu 
    530                 535                 540                 


Val Phe Pro Ala Ile Leu Ser Leu Asp Leu Arg Arg Arg His Cys Gln 
545                 550                 555                 560 


Arg Leu Asp Val Leu Cys Cys Phe Ser Ser Pro Cys Ser Ala Gln Val 
                565                 570                 575     


Ile Gln Ile Leu Pro Gln Glu Leu Gly Asp Gly Thr Val Pro Val Gly 
            580                 585                 590         


Ile Ala His Leu Thr Ala Thr Val Gln Ala Phe Thr His Cys Glu Ala 
        595                 600                 605             


Ser Ser Gln His Val Val Thr Ile Leu Pro Pro Gln Ala His Leu Val 
    610                 615                 620                 


Pro Pro Pro Ser Asp Pro Leu Gly Ser Glu Leu Phe Ser Pro Gly Gly 
625                 630                 635                 640 


Ser Thr Arg Asp Leu Leu Gly Gln Glu Glu Glu Thr Arg Gln Lys Ala 
                645                 650                 655     


Ala Cys Lys Ser Leu Pro Cys Ala Arg Trp Asn Leu Ala His Phe Ala 
            660                 665                 670         


Arg Tyr Gln Phe Ala Pro Leu Leu Leu Gln Ser His Ala Lys Ala Ile 
        675                 680                 685             


Val Leu Val Leu Phe Gly Ala Leu Leu Gly Leu Ser Leu Tyr Gly Ala 
    690                 695                 700                 


Thr Leu Val Gln Asp Gly Leu Ala Leu Thr Asp Val Val Pro Arg Gly 
705                 710                 715                 720 


Thr Lys Glu His Ala Phe Leu Ser Ala Gln Leu Arg Tyr Phe Ser Leu 
                725                 730                 735     


Tyr Glu Val Ala Leu Val Thr Gln Gly Gly Phe Asp Tyr Ala His Ser 
            740                 745                 750         


Gln Arg Ala Leu Phe Asp Leu His Gln Arg Phe Ser Ser Leu Lys Ala 
        755                 760                 765             


Val Leu Pro Pro Pro Ala Thr Gln Ala Pro Arg Thr Trp Leu His Tyr 
    770                 775                 780                 


Tyr Arg Asn Trp Leu Gln Gly Ile Gln Ala Ala Phe Asp Gln Asp Trp 
785                 790                 795                 800 


Ala Ser Gly Arg Ile Thr Arg His Ser Tyr Arg Asn Gly Ser Glu Asp 
                805                 810                 815     


Gly Ala Leu Ala Tyr Lys Leu Leu Ile Gln Thr Gly Asp Ala Gln Glu 
            820                 825                 830         


Pro Leu Asp Phe Ser Gln Leu Thr Thr Arg Lys Leu Val Asp Arg Glu 
        835                 840                 845             


Gly Leu Ile Pro Pro Glu Leu Phe Tyr Met Gly Leu Thr Val Trp Val 
    850                 855                 860                 


Ser Ser Asp Pro Leu Gly Leu Ala Ala Ser Gln Ala Asn Phe Tyr Pro 
865                 870                 875                 880 


Pro Pro Pro Glu Trp Leu His Asp Lys Tyr Asp Thr Thr Gly Glu Asn 
                885                 890                 895     


Leu Arg Ile Pro Pro Ala Gln Pro Leu Glu Phe Ala Gln Phe Pro Phe 
            900                 905                 910         


Leu Leu Arg Gly Leu Gln Lys Thr Ala Asp Phe Val Glu Ala Ile Glu 
        915                 920                 925             


Gly Ala Arg Ala Ala Cys Ala Glu Ala Gly Gln Ala Gly Val His Ala 
    930                 935                 940                 


Tyr Pro Ser Gly Ser Pro Phe Leu Phe Trp Glu Gln Tyr Leu Gly Leu 
945                 950                 955                 960 


Arg Arg Cys Phe Leu Leu Ala Val Cys Ile Leu Leu Val Cys Thr Phe 
                965                 970                 975     


Leu Val Cys Ala Leu Leu Leu Leu Asn Pro Trp Thr Ala Gly Leu Ile 
            980                 985                 990         


Val Leu Val Leu Ala Met Met Thr  Val Glu Leu Phe Gly  Ile Met Gly 
        995                 1000                 1005             


Phe Leu  Gly Ile Lys Leu Ser  Ala Ile Pro Val Val  Ile Leu Val 
    1010                 1015                 1020             


Ala Ser  Val Gly Ile Gly Val  Glu Phe Thr Val His  Val Ala Leu 
    1025                 1030                 1035             


Gly Phe  Leu Thr Thr Gln Gly  Ser Arg Asn Leu Arg  Ala Ala His 
    1040                 1045                 1050             


Ala Leu  Glu His Thr Phe Ala  Pro Val Thr Asp Gly  Ala Ile Ser 
    1055                 1060                 1065             


Thr Leu  Leu Gly Leu Leu Met  Leu Ala Gly Ser His  Phe Asp Phe 
    1070                 1075                 1080             


Ile Val  Arg Tyr Phe Phe Ala  Ala Leu Thr Val Leu  Thr Leu Leu 
    1085                 1090                 1095             


Gly Leu  Leu His Gly Leu Val  Leu Leu Pro Val Leu  Leu Ser Ile 
    1100                 1105                 1110             


Leu Gly  Pro Pro Pro Glu Val  Ile Gln Met Tyr Lys  Glu Ser Pro 
    1115                 1120                 1125             


Glu Ile  Leu Ser Pro Pro Ala  Pro Gln Gly Gly Gly  Leu Arg Trp 
    1130                 1135                 1140             


Gly Ala  Ser Ser Ser Leu Pro  Gln Ser Phe Ala Arg  Val Thr Thr 
    1145                 1150                 1155             


Ser Met  Thr Val Ala Ile His  Pro Pro Pro Leu Pro  Gly Ala Tyr 
    1160                 1165                 1170             


Ile His  Pro Ala Pro Asp Glu  Pro Pro Trp Ser Pro  Ala Ala Thr 
    1175                 1180                 1185             


Ser Ser  Gly Asn Leu Ser Ser  Arg Gly Pro Gly Pro  Ala Thr Gly 
    1190                 1195                 1200             


<210> 9
<211> 1146
<212> PRT
<213> Homo sapiens

<400> 9
Met Thr Arg Ser Pro Pro Leu Arg Glu Leu Pro Pro Ser Tyr Thr Pro 
1               5                   10                  15      


Pro Ala Arg Thr Ala Ala Pro Gln Ile Leu Ala Gly Ser Leu Lys Ala 
            20                  25                  30          


Pro Leu Trp Leu Arg Ala Tyr Phe Gln Gly Leu Leu Phe Ser Leu Gly 
        35                  40                  45              


Cys Gly Ile Gln Arg His Cys Gly Lys Val Leu Phe Leu Gly Leu Leu 
    50                  55                  60                  


Ala Phe Gly Ala Leu Ala Leu Gly Leu Arg Met Ala Ile Ile Glu Thr 
65                  70                  75                  80  


Asn Leu Glu Gln Leu Trp Val Glu Val Gly Ser Arg Val Ser Gln Glu 
                85                  90                  95      


Leu His Tyr Thr Lys Glu Lys Leu Gly Glu Glu Ala Ala Tyr Thr Ser 
            100                 105                 110         


Gln Met Leu Ile Gln Thr Ala Arg Gln Glu Gly Glu Asn Ile Leu Thr 
        115                 120                 125             


Pro Glu Ala Leu Gly Leu His Leu Gln Ala Ala Leu Thr Ala Ser Lys 
    130                 135                 140                 


Val Gln Val Ser Leu Tyr Gly Lys Ser Trp Asp Leu Asn Lys Ile Cys 
145                 150                 155                 160 


Tyr Lys Ser Gly Val Pro Leu Ile Glu Asn Gly Met Ile Glu Arg Met 
                165                 170                 175     


Ile Glu Lys Leu Phe Pro Cys Val Ile Leu Thr Pro Leu Asp Cys Phe 
            180                 185                 190         


Trp Glu Gly Ala Lys Leu Gln Gly Gly Ser Ala Tyr Leu Pro Gly Arg 
        195                 200                 205             


Pro Asp Ile Gln Trp Thr Asn Leu Asp Pro Glu Gln Leu Leu Glu Glu 
    210                 215                 220                 


Leu Gly Pro Phe Ala Ser Leu Glu Gly Phe Arg Glu Leu Leu Asp Lys 
225                 230                 235                 240 


Ala Gln Val Gly Gln Ala Tyr Val Gly Arg Pro Cys Leu His Pro Asp 
                245                 250                 255     


Asp Leu His Cys Pro Pro Ser Ala Pro Asn His His Ser Arg Gln Ala 
            260                 265                 270         


Pro Asn Val Ala His Glu Leu Ser Gly Gly Cys His Gly Phe Ser His 
        275                 280                 285             


Lys Phe Met His Trp Gln Glu Glu Leu Leu Leu Gly Gly Met Ala Arg 
    290                 295                 300                 


Asp Pro Gln Gly Glu Leu Leu Arg Ala Glu Ala Leu Gln Ser Thr Phe 
305                 310                 315                 320 


Leu Leu Met Ser Pro Arg Gln Leu Tyr Glu His Phe Arg Gly Asp Tyr 
                325                 330                 335     


Gln Thr His Asp Ile Gly Trp Ser Glu Glu Gln Ala Ser Thr Val Leu 
            340                 345                 350         


Gln Ala Trp Gln Arg Arg Phe Val Gln Leu Ala Gln Glu Ala Leu Pro 
        355                 360                 365             


Glu Asn Ala Ser Gln Gln Ile His Ala Phe Ser Ser Thr Thr Leu Asp 
    370                 375                 380                 


Asp Ile Leu His Ala Phe Ser Glu Val Ser Ala Ala Arg Val Val Gly 
385                 390                 395                 400 


Gly Tyr Leu Leu Met Leu Ala Tyr Ala Cys Val Thr Met Leu Arg Trp 
                405                 410                 415     


Asp Cys Ala Gln Ser Gln Gly Ser Val Gly Leu Ala Gly Val Leu Leu 
            420                 425                 430         


Val Ala Leu Ala Val Ala Ser Gly Leu Gly Leu Cys Ala Leu Leu Gly 
        435                 440                 445             


Ile Thr Phe Asn Ala Ala Thr Thr Gln Val Leu Pro Phe Leu Ala Leu 
    450                 455                 460                 


Gly Ile Gly Val Asp Asp Val Phe Leu Leu Ala His Ala Phe Thr Glu 
465                 470                 475                 480 


Ala Leu Pro Gly Thr Pro Leu Gln Glu Arg Met Gly Glu Cys Leu Gln 
                485                 490                 495     


Arg Thr Gly Thr Ser Val Val Leu Thr Ser Ile Asn Asn Met Ala Ala 
            500                 505                 510         


Phe Leu Met Ala Ala Leu Val Pro Ile Pro Ala Leu Arg Ala Phe Ser 
        515                 520                 525             


Leu Gln Ala Ala Ile Val Val Gly Cys Thr Phe Val Ala Val Met Leu 
    530                 535                 540                 


Val Phe Pro Ala Ile Leu Ser Leu Asp Leu Arg Arg Arg His Cys Gln 
545                 550                 555                 560 


Arg Leu Asp Val Leu Cys Cys Phe Ser Ser Pro Cys Ser Ala Gln Val 
                565                 570                 575     


Ile Gln Ile Leu Pro Gln Glu Leu Gly Asp Gly Thr Val Pro Val Gly 
            580                 585                 590         


Ile Ala His Leu Thr Ala Thr Val Gln Ala Phe Thr His Cys Glu Ala 
        595                 600                 605             


Ser Ser Gln His Val Val Thr Ile Leu Pro Pro Gln Ala His Leu Val 
    610                 615                 620                 


Pro Pro Pro Ser Asp Pro Leu Gly Ser Glu Leu Phe Ser Pro Gly Gly 
625                 630                 635                 640 


Ser Thr Arg Asp Leu Leu Gly Gln Glu Glu Glu Thr Arg Gln Lys Ala 
                645                 650                 655     


Ala Cys Lys Ser Leu Pro Cys Ala Arg Trp Asn Leu Ala His Phe Ala 
            660                 665                 670         


Arg Tyr Gln Phe Ala Pro Leu Leu Leu Gln Ser His Ala Lys Ala Ile 
        675                 680                 685             


Val Leu Val Leu Phe Gly Ala Leu Leu Gly Leu Ser Leu Tyr Gly Ala 
    690                 695                 700                 


Thr Leu Val Gln Asp Gly Leu Ala Leu Thr Asp Val Val Pro Arg Gly 
705                 710                 715                 720 


Thr Lys Glu His Ala Phe Leu Ser Ala Gln Leu Arg Tyr Phe Ser Leu 
                725                 730                 735     


Tyr Glu Val Ala Leu Val Thr Gln Gly Gly Phe Asp Tyr Ala His Ser 
            740                 745                 750         


Gln Arg Ala Leu Phe Asp Leu His Gln Arg Phe Ser Ser Leu Lys Ala 
        755                 760                 765             


Val Leu Pro Pro Pro Ala Thr Gln Ala Pro Arg Thr Trp Leu His Tyr 
    770                 775                 780                 


Tyr Arg Asn Trp Leu Gln Gly Ile Gln Ala Ala Phe Asp Gln Asp Trp 
785                 790                 795                 800 


Ala Ser Gly Arg Ile Thr Arg His Ser Tyr Arg Asn Gly Ser Glu Asp 
                805                 810                 815     


Gly Ala Leu Ala Tyr Lys Leu Leu Ile Gln Thr Gly Asp Ala Gln Glu 
            820                 825                 830         


Pro Leu Asp Phe Ser Gln Leu Thr Thr Arg Lys Leu Val Asp Arg Glu 
        835                 840                 845             


Gly Leu Ile Pro Pro Glu Leu Phe Tyr Met Gly Leu Thr Val Trp Val 
    850                 855                 860                 


Ser Ser Asp Pro Leu Gly Leu Ala Ala Ser Gln Ala Asn Phe Tyr Pro 
865                 870                 875                 880 


Pro Pro Pro Glu Trp Leu His Asp Lys Tyr Asp Thr Thr Gly Glu Asn 
                885                 890                 895     


Leu Arg Ile Pro Pro Ala Gln Pro Leu Glu Phe Ala Gln Phe Pro Phe 
            900                 905                 910         


Leu Leu Arg Gly Leu Gln Lys Thr Ala Asp Phe Val Glu Ala Ile Glu 
        915                 920                 925             


Gly Ala Arg Ala Ala Cys Ala Glu Ala Gly Gln Ala Gly Val His Ala 
    930                 935                 940                 


Tyr Pro Ser Gly Ser Pro Phe Leu Phe Trp Glu Gln Tyr Leu Gly Leu 
945                 950                 955                 960 


Arg Arg Cys Phe Leu Leu Ala Val Cys Ile Leu Leu Val Cys Thr Phe 
                965                 970                 975     


Leu Val Cys Ala Leu Leu Leu Leu Asn Pro Trp Thr Ala Gly Leu Ile 
            980                 985                 990         


Val Leu Val Leu Ala Met Met Thr  Val Glu Leu Phe Gly  Ile Met Gly 
        995                 1000                 1005             


Phe Leu  Gly Ile Lys Leu Ser  Ala Ile Pro Val Val  Ile Leu Val 
    1010                 1015                 1020             


Ala Ser  Val Gly Ile Gly Val  Glu Phe Thr Val His  Val Ala Leu 
    1025                 1030                 1035             


Gly Phe  Leu Thr Thr Gln Gly  Ser Arg Asn Leu Arg  Ala Ala His 
    1040                 1045                 1050             


Ala Leu  Glu His Thr Phe Ala  Pro Val Thr Asp Gly  Ala Ile Ser 
    1055                 1060                 1065             


Thr Leu  Leu Gly Leu Leu Met  Leu Ala Gly Ser His  Phe Asp Phe 
    1070                 1075                 1080             


Ile Val  Arg Tyr Phe Phe Ala  Ala Leu Thr Val Leu  Thr Leu Leu 
    1085                 1090                 1095             


Gly Leu  Leu His Gly Leu Val  Leu Leu Pro Val Leu  Leu Ser Ile 
    1100                 1105                 1110             


Leu Gly  Pro Pro Pro Glu Val  Ile Gln Met Tyr Lys  Glu Ser Pro 
    1115                 1120                 1125             


Glu Ile  Leu Ser Pro Pro Ala  Pro Gln Gly Gly Gly  Leu Arg Pro 
    1130                 1135                 1140             


Glu Glu  Ile 
    1145     


<210> 10
<211> 787
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Ala Ala Arg Pro Ala Arg Gly Pro Glu Leu Pro Leu Leu Gly 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Asp Pro Gly Arg Gly Ala Ala Ser 
            20                  25                  30          


Ser Gly Asn Ala Thr Gly Pro Gly Pro Arg Ser Ala Gly Gly Ser Ala 
        35                  40                  45              


Arg Arg Ser Ala Ala Val Thr Gly Pro Pro Pro Pro Leu Ser His Cys 
    50                  55                  60                  


Gly Arg Ala Ala Pro Cys Glu Pro Leu Arg Tyr Asn Val Cys Leu Gly 
65                  70                  75                  80  


Ser Val Leu Pro Tyr Gly Ala Thr Ser Thr Leu Leu Ala Gly Asp Ser 
                85                  90                  95      


Asp Ser Gln Glu Glu Ala His Gly Lys Leu Val Leu Trp Ser Gly Leu 
            100                 105                 110         


Arg Asn Ala Pro Arg Cys Trp Ala Val Ile Gln Pro Leu Leu Cys Ala 
        115                 120                 125             


Val Tyr Met Pro Lys Cys Glu Asn Asp Arg Val Glu Leu Pro Ser Arg 
    130                 135                 140                 


Thr Leu Cys Gln Ala Thr Arg Gly Pro Cys Ala Ile Val Glu Arg Glu 
145                 150                 155                 160 


Arg Gly Trp Pro Asp Phe Leu Arg Cys Thr Pro Asp Arg Phe Pro Glu 
                165                 170                 175     


Gly Cys Thr Asn Glu Val Gln Asn Ile Lys Phe Asn Ser Ser Gly Gln 
            180                 185                 190         


Cys Glu Val Pro Leu Val Arg Thr Asp Asn Pro Lys Ser Trp Tyr Glu 
        195                 200                 205             


Asp Val Glu Gly Cys Gly Ile Gln Cys Gln Asn Pro Leu Phe Thr Glu 
    210                 215                 220                 


Ala Glu His Gln Asp Met His Ser Tyr Ile Ala Ala Phe Gly Ala Val 
225                 230                 235                 240 


Thr Gly Leu Cys Thr Leu Phe Thr Leu Ala Thr Phe Val Ala Asp Trp 
                245                 250                 255     


Arg Asn Ser Asn Arg Tyr Pro Ala Val Ile Leu Phe Tyr Val Asn Ala 
            260                 265                 270         


Cys Phe Phe Val Gly Ser Ile Gly Trp Leu Ala Gln Phe Met Asp Gly 
        275                 280                 285             


Ala Arg Arg Glu Ile Val Cys Arg Ala Asp Gly Thr Met Arg Leu Gly 
    290                 295                 300                 


Glu Pro Thr Ser Asn Glu Thr Leu Ser Cys Val Ile Ile Phe Val Ile 
305                 310                 315                 320 


Val Tyr Tyr Ala Leu Met Ala Gly Val Val Trp Phe Val Val Leu Thr 
                325                 330                 335     


Tyr Ala Trp His Thr Ser Phe Lys Ala Leu Gly Thr Thr Tyr Gln Pro 
            340                 345                 350         


Leu Ser Gly Lys Thr Ser Tyr Phe His Leu Leu Thr Trp Ser Leu Pro 
        355                 360                 365             


Phe Val Leu Thr Val Ala Ile Leu Ala Val Ala Gln Val Asp Gly Asp 
    370                 375                 380                 


Ser Val Ser Gly Ile Cys Phe Val Gly Tyr Lys Asn Tyr Arg Tyr Arg 
385                 390                 395                 400 


Ala Gly Phe Val Leu Ala Pro Ile Gly Leu Val Leu Ile Val Gly Gly 
                405                 410                 415     


Tyr Phe Leu Ile Arg Gly Val Met Thr Leu Phe Ser Ile Lys Ser Asn 
            420                 425                 430         


His Pro Gly Leu Leu Ser Glu Lys Ala Ala Ser Lys Ile Asn Glu Thr 
        435                 440                 445             


Met Leu Arg Leu Gly Ile Phe Gly Phe Leu Ala Phe Gly Phe Val Leu 
    450                 455                 460                 


Ile Thr Phe Ser Cys His Phe Tyr Asp Phe Phe Asn Gln Ala Glu Trp 
465                 470                 475                 480 


Glu Arg Ser Phe Arg Asp Tyr Val Leu Cys Gln Ala Asn Val Thr Ile 
                485                 490                 495     


Gly Leu Pro Thr Lys Gln Pro Ile Pro Asp Cys Glu Ile Lys Asn Arg 
            500                 505                 510         


Pro Ser Leu Leu Val Glu Lys Ile Asn Leu Phe Ala Met Phe Gly Thr 
        515                 520                 525             


Gly Ile Ala Met Ser Thr Trp Val Trp Thr Lys Ala Thr Leu Leu Ile 
    530                 535                 540                 


Trp Arg Arg Thr Trp Cys Arg Leu Thr Gly Gln Ser Asp Asp Glu Pro 
545                 550                 555                 560 


Lys Arg Ile Lys Lys Ser Lys Met Ile Ala Lys Ala Phe Ser Lys Arg 
                565                 570                 575     


His Glu Leu Leu Gln Asn Pro Gly Gln Glu Leu Ser Phe Ser Met His 
            580                 585                 590         


Thr Val Ser His Asp Gly Pro Val Ala Gly Leu Ala Phe Asp Leu Asn 
        595                 600                 605             


Glu Pro Ser Ala Asp Val Ser Ser Ala Trp Ala Gln His Val Thr Lys 
    610                 615                 620                 


Met Val Ala Arg Arg Gly Ala Ile Leu Pro Gln Asp Ile Ser Val Thr 
625                 630                 635                 640 


Pro Val Ala Thr Pro Val Pro Pro Glu Glu Gln Ala Asn Leu Trp Leu 
                645                 650                 655     


Val Glu Ala Glu Ile Ser Pro Glu Leu Gln Lys Arg Leu Gly Arg Lys 
            660                 665                 670         


Lys Lys Arg Arg Lys Arg Lys Lys Glu Val Cys Pro Leu Ala Pro Pro 
        675                 680                 685             


Pro Glu Leu His Pro Pro Ala Pro Ala Pro Ser Thr Ile Pro Arg Leu 
    690                 695                 700                 


Pro Gln Leu Pro Arg Gln Lys Cys Leu Val Ala Ala Gly Ala Trp Gly 
705                 710                 715                 720 


Ala Gly Asp Ser Cys Arg Gln Gly Ala Trp Thr Leu Val Ser Asn Pro 
                725                 730                 735     


Phe Cys Pro Glu Pro Ser Pro Pro Gln Asp Pro Phe Leu Pro Ser Ala 
            740                 745                 750         


Pro Ala Pro Val Ala Trp Ala His Gly Arg Arg Gln Gly Leu Gly Pro 
        755                 760                 765             


Ile His Ser Arg Thr Asn Leu Met Asp Thr Glu Leu Met Asp Ala Asp 
    770                 775                 780                 


Ser Asp Phe 
785         


<210> 11
<211> 484
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Glu Leu Arg Pro Ser Gly Ala Pro Gly Pro Thr Ala Pro Pro 
1               5                   10                  15      


Ala Pro Gly Pro Thr Ala Pro Pro Ala Phe Ala Ser Leu Phe Pro Pro 
            20                  25                  30          


Gly Leu His Ala Ile Tyr Gly Glu Cys Arg Arg Leu Tyr Pro Asp Gln 
        35                  40                  45              


Pro Asn Pro Leu Gln Val Thr Ala Ile Val Lys Tyr Trp Leu Gly Gly 
    50                  55                  60                  


Pro Asp Pro Leu Asp Tyr Val Ser Met Tyr Arg Asn Val Gly Ser Pro 
65                  70                  75                  80  


Ser Ala Asn Ile Pro Glu His Trp His Tyr Ile Ser Phe Gly Leu Ser 
                85                  90                  95      


Asp Leu Tyr Gly Asp Asn Arg Val His Glu Phe Thr Gly Thr Asp Gly 
            100                 105                 110         


Pro Ser Gly Phe Gly Phe Glu Leu Thr Phe Arg Leu Lys Arg Glu Thr 
        115                 120                 125             


Gly Glu Ser Ala Pro Pro Thr Trp Pro Ala Glu Leu Met Gln Gly Leu 
    130                 135                 140                 


Ala Arg Tyr Val Phe Gln Ser Glu Asn Thr Phe Cys Ser Gly Asp His 
145                 150                 155                 160 


Val Ser Trp His Ser Pro Leu Asp Asn Ser Glu Ser Arg Ile Gln His 
                165                 170                 175     


Met Leu Leu Thr Glu Asp Pro Gln Met Gln Pro Val Gln Thr Pro Phe 
            180                 185                 190         


Gly Val Val Thr Phe Leu Gln Ile Val Gly Val Cys Thr Glu Glu Leu 
        195                 200                 205             


His Ser Ala Gln Gln Trp Asn Gly Gln Gly Ile Leu Glu Leu Leu Arg 
    210                 215                 220                 


Thr Val Pro Ile Ala Gly Gly Pro Trp Leu Ile Thr Asp Met Arg Arg 
225                 230                 235                 240 


Gly Glu Thr Ile Phe Glu Ile Asp Pro His Leu Gln Glu Arg Val Asp 
                245                 250                 255     


Lys Gly Ile Glu Thr Asp Gly Ser Asn Leu Ser Gly Val Ser Ala Lys 
            260                 265                 270         


Cys Ala Trp Asp Asp Leu Ser Arg Pro Pro Glu Asp Asp Glu Asp Ser 
        275                 280                 285             


Arg Ser Ile Cys Ile Gly Thr Gln Pro Arg Arg Leu Ser Gly Lys Asp 
    290                 295                 300                 


Thr Glu Gln Ile Arg Glu Thr Leu Arg Arg Gly Leu Glu Ile Asn Ser 
305                 310                 315                 320 


Lys Pro Val Leu Pro Pro Ile Asn Pro Gln Arg Gln Asn Gly Leu Ala 
                325                 330                 335     


His Asp Arg Ala Pro Ser Arg Lys Asp Ser Leu Glu Ser Asp Ser Ser 
            340                 345                 350         


Thr Ala Ile Ile Pro His Glu Leu Ile Arg Thr Arg Gln Leu Glu Ser 
        355                 360                 365             


Val His Leu Lys Phe Asn Gln Glu Ser Gly Ala Leu Ile Pro Leu Cys 
    370                 375                 380                 


Leu Arg Gly Arg Leu Leu His Gly Arg His Phe Thr Tyr Lys Ser Ile 
385                 390                 395                 400 


Thr Gly Asp Met Ala Ile Thr Phe Val Ser Thr Gly Val Glu Gly Ala 
                405                 410                 415     


Phe Ala Thr Glu Glu His Pro Tyr Ala Ala His Gly Pro Trp Leu Gln 
            420                 425                 430         


Ile Leu Leu Thr Glu Glu Phe Val Glu Lys Met Leu Glu Asp Leu Glu 
        435                 440                 445             


Asp Leu Thr Ser Pro Glu Glu Phe Lys Leu Pro Lys Glu Tyr Ser Trp 
    450                 455                 460                 


Pro Glu Lys Lys Leu Lys Val Ser Ile Leu Pro Asp Val Val Phe Asp 
465                 470                 475                 480 


Ser Pro Leu His 
                


<210> 12
<211> 433
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Glu Leu Arg Pro Ser Gly Ala Pro Gly Pro Thr Ala Pro Pro 
1               5                   10                  15      


Ala Pro Gly Pro Thr Ala Pro Pro Ala Phe Ala Ser Leu Phe Pro Pro 
            20                  25                  30          


Gly Leu His Ala Ile Tyr Gly Glu Cys Arg Arg Leu Tyr Pro Asp Gln 
        35                  40                  45              


Pro Asn Pro Leu Gln Val Thr Ala Ile Val Lys Tyr Trp Leu Gly Gly 
    50                  55                  60                  


Pro Asp Pro Leu Asp Tyr Val Ser Met Tyr Arg Asn Val Gly Ser Pro 
65                  70                  75                  80  


Ser Ala Asn Ile Pro Glu His Trp His Tyr Ile Ser Phe Gly Leu Ser 
                85                  90                  95      


Asp Leu Tyr Gly Asp Asn Arg Val His Glu Phe Thr Gly Thr Asp Gly 
            100                 105                 110         


Pro Ser Gly Phe Gly Phe Glu Leu Thr Phe Arg Leu Lys Arg Glu Thr 
        115                 120                 125             


Gly Glu Ser Ala Pro Pro Thr Trp Pro Ala Glu Leu Met Gln Gly Leu 
    130                 135                 140                 


Ala Arg Tyr Val Phe Gln Ser Glu Asn Thr Phe Cys Ser Gly Asp His 
145                 150                 155                 160 


Val Ser Trp His Ser Pro Leu Asp Asn Ser Glu Ser Arg Ile Gln His 
                165                 170                 175     


Met Leu Leu Thr Glu Asp Pro Gln Met Gln Pro Val Gln Thr Pro Phe 
            180                 185                 190         


Gly Val Val Thr Phe Leu Gln Ile Val Gly Val Cys Thr Glu Glu Leu 
        195                 200                 205             


His Ser Ala Gln Gln Trp Asn Gly Gln Gly Ile Leu Glu Leu Leu Arg 
    210                 215                 220                 


Thr Val Pro Ile Ala Gly Gly Pro Trp Leu Ile Thr Asp Met Arg Arg 
225                 230                 235                 240 


Gly Glu Thr Ile Phe Glu Ile Asp Pro His Leu Gln Glu Arg Val Asp 
                245                 250                 255     


Lys Gly Ile Glu Thr Asp Gly Ser Asn Leu Ser Gly Val Ser Ala Lys 
            260                 265                 270         


Cys Ala Trp Asp Asp Leu Ser Arg Pro Pro Glu Asp Asp Glu Asp Ser 
        275                 280                 285             


Arg Ser Ile Cys Ile Gly Thr Gln Pro Arg Arg Leu Ser Gly Lys Asp 
    290                 295                 300                 


Thr Glu Gln Ile Arg Glu Thr Leu Arg Arg Gly Leu Glu Ile Asn Ser 
305                 310                 315                 320 


Lys Pro Val Leu Pro Pro Ile Asn Pro Gln Arg Gln Asn Gly Leu Ala 
                325                 330                 335     


His Asp Arg Ala Pro Ser Arg Lys Asp Ser Leu Glu Ser Asp Ser Ser 
            340                 345                 350         


Thr Ala Ile Ile Pro His Glu Leu Ile Arg Thr Arg Gln Leu Glu Ser 
        355                 360                 365             


Val His Leu Lys Phe Asn Gln Glu Ser Gly Ala Leu Ile Pro Leu Cys 
    370                 375                 380                 


Leu Arg Gly Arg Leu Leu His Gly Arg His Phe Thr Tyr Lys Ser Ile 
385                 390                 395                 400 


Thr Gly Asp Met Ala Ile Thr Phe Val Ser Thr Gly Val Glu Gly Ala 
                405                 410                 415     


Phe Ala Thr Glu Glu His Pro Tyr Ala Ala His Gly Pro Trp Leu Gln 
            420                 425                 430         


Leu 
    


<210> 13
<211> 481
<212> PRT
<213> Homo sapiens

<400> 13
Met Ala Glu Leu Arg Pro Ser Gly Ala Pro Gly Pro Thr Ala Pro Pro 
1               5                   10                  15      


Ala Pro Gly Pro Thr Ala Pro Pro Ala Phe Ala Ser Leu Phe Pro Pro 
            20                  25                  30          


Gly Leu His Ala Ile Tyr Gly Glu Cys Arg Arg Leu Tyr Pro Asp Gln 
        35                  40                  45              


Pro Asn Pro Leu Gln Val Thr Ala Ile Val Lys Tyr Trp Leu Gly Gly 
    50                  55                  60                  


Pro Asp Pro Leu Asp Tyr Val Ser Met Tyr Arg Asn Val Gly Ser Pro 
65                  70                  75                  80  


Ser Ala Asn Ile Pro Glu His Trp His Tyr Ile Ser Phe Gly Leu Ser 
                85                  90                  95      


Asp Leu Tyr Gly Asp Asn Arg Val His Glu Phe Thr Gly Thr Asp Gly 
            100                 105                 110         


Pro Ser Gly Phe Gly Phe Glu Leu Thr Phe Arg Leu Lys Arg Glu Thr 
        115                 120                 125             


Gly Glu Ser Ala Pro Pro Thr Trp Pro Ala Glu Leu Met Gln Gly Leu 
    130                 135                 140                 


Ala Arg Tyr Val Phe Gln Ser Glu Asn Thr Phe Cys Ser Gly Asp His 
145                 150                 155                 160 


Val Ser Trp His Ser Pro Leu Asp Asn Ser Glu Ser Arg Ile Gln His 
                165                 170                 175     


Met Leu Leu Thr Glu Asp Pro Gln Met Gln Pro Val Gln Thr Pro Phe 
            180                 185                 190         


Gly Val Val Thr Phe Leu Gln Ile Val Gly Val Cys Thr Glu Glu Leu 
        195                 200                 205             


His Ser Ala Gln Gln Trp Asn Gly Gln Gly Ile Leu Glu Leu Leu Arg 
    210                 215                 220                 


Thr Val Pro Ile Ala Gly Gly Pro Trp Leu Ile Thr Asp Met Arg Arg 
225                 230                 235                 240 


Gly Glu Thr Ile Phe Glu Ile Asp Pro His Leu Gln Glu Arg Val Asp 
                245                 250                 255     


Lys Gly Ile Glu Thr Asp Gly Ser Asn Leu Ser Gly Val Ser Ala Lys 
            260                 265                 270         


Cys Ala Trp Asp Asp Leu Ser Arg Pro Pro Glu Asp Asp Glu Asp Ser 
        275                 280                 285             


Arg Ser Ile Cys Ile Gly Thr Gln Pro Arg Arg Leu Ser Gly Lys Asp 
    290                 295                 300                 


Thr Glu Gln Ile Arg Glu Thr Leu Arg Arg Gly Leu Glu Ile Asn Ser 
305                 310                 315                 320 


Lys Pro Val Leu Pro Pro Ile Asn Pro Gln Arg Gln Asn Gly Leu Ala 
                325                 330                 335     


His Asp Arg Ala Pro Ser Arg Lys Asp Ser Leu Glu Ser Asp Ser Ser 
            340                 345                 350         


Thr Ala Ile Ile Pro His Glu Leu Ile Arg Thr Arg Gln Leu Glu Ser 
        355                 360                 365             


Val His Leu Lys Phe Asn Gln Glu Ser Gly Ala Leu Ile Pro Leu Cys 
    370                 375                 380                 


Leu Arg Gly Arg Leu Leu His Gly Arg His Phe Thr Tyr Lys Ser Ile 
385                 390                 395                 400 


Thr Gly Asp Met Ala Ile Thr Phe Val Ser Thr Gly Val Glu Gly Ala 
                405                 410                 415     


Phe Ala Thr Glu Glu His Pro Tyr Ala Ala His Gly Pro Trp Leu Gln 
            420                 425                 430         


Val Arg Arg Pro Phe Phe Phe Ser Leu Leu Pro Phe Ile Asp Phe Leu 
        435                 440                 445             


Ala His Pro Ser Ser Ser Pro Leu Ala Ala Leu Asp Gly Thr Pro Ser 
    450                 455                 460                 


Trp Gly Ala Gly His Glu Cys Leu Met Asp Ser Gly Pro Gly Ala Cys 
465                 470                 475                 480 


Val 
    


<210> 14
<211> 1343
<212> PRT
<213> Homo sapiens

<400> 14
Met Gly Leu Glu Ala Gln Arg Leu Pro Gly Ala Glu Glu Ala Pro Val 
1               5                   10                  15      


Arg Val Ala Leu Arg Val Arg Pro Leu Leu Pro Lys Glu Leu Leu His 
            20                  25                  30          


Gly His Gln Ser Cys Leu Gln Val Glu Pro Gly Leu Gly Arg Val Thr 
        35                  40                  45              


Leu Gly Arg Asp Arg His Phe Gly Phe His Val Val Leu Ala Glu Asp 
    50                  55                  60                  


Ala Gly Gln Glu Ala Val Tyr Gln Ala Cys Val Gln Pro Leu Leu Glu 
65                  70                  75                  80  


Ala Phe Phe Glu Gly Phe Asn Ala Thr Val Phe Ala Tyr Gly Gln Thr 
                85                  90                  95      


Gly Ser Gly Lys Thr Tyr Thr Met Gly Glu Ala Ser Val Ala Ser Leu 
            100                 105                 110         


Leu Glu Asp Glu Gln Gly Ile Val Pro Arg Ala Met Ala Glu Ala Phe 
        115                 120                 125             


Lys Leu Ile Asp Glu Asn Asp Leu Leu Asp Cys Leu Val His Val Ser 
    130                 135                 140                 


Tyr Leu Glu Val Tyr Lys Glu Glu Phe Arg Asp Leu Leu Glu Val Gly 
145                 150                 155                 160 


Thr Ala Ser Arg Asp Ile Gln Leu Arg Glu Asp Glu Arg Gly Asn Val 
                165                 170                 175     


Val Leu Cys Gly Val Lys Glu Val Asp Val Glu Gly Leu Asp Glu Val 
            180                 185                 190         


Leu Ser Leu Leu Glu Met Gly Asn Ala Ala Arg His Thr Gly Ala Thr 
        195                 200                 205             


His Leu Asn His Leu Ser Ser Arg Ser His Thr Val Phe Thr Val Thr 
    210                 215                 220                 


Leu Glu Gln Arg Gly Arg Ala Pro Ser Arg Leu Pro Arg Pro Ala Pro 
225                 230                 235                 240 


Gly Gln Leu Leu Val Ser Lys Phe His Phe Val Asp Leu Ala Gly Ser 
                245                 250                 255     


Glu Arg Val Leu Lys Thr Gly Ser Thr Gly Glu Arg Leu Lys Glu Ser 
            260                 265                 270         


Ile Gln Ile Asn Ser Ser Leu Leu Ala Leu Gly Asn Val Ile Ser Ala 
        275                 280                 285             


Leu Gly Asp Pro Gln Arg Arg Gly Ser His Ile Pro Tyr Arg Asp Ser 
    290                 295                 300                 


Lys Ile Thr Arg Ile Leu Lys Asp Ser Leu Gly Gly Asn Ala Lys Thr 
305                 310                 315                 320 


Val Met Ile Ala Cys Val Ser Pro Ser Ser Ser Asp Phe Asp Glu Thr 
                325                 330                 335     


Leu Asn Thr Leu Asn Tyr Ala Ser Arg Ala Gln Asn Ile Arg Asn Arg 
            340                 345                 350         


Ala Thr Val Asn Trp Arg Pro Glu Ala Glu Arg Pro Pro Glu Glu Thr 
        355                 360                 365             


Ala Ser Gly Ala Arg Gly Pro Pro Arg His Arg Ser Glu Thr Arg Ile 
    370                 375                 380                 


Ile His Arg Gly Arg Arg Ala Pro Gly Pro Ala Thr Ala Ser Ala Ala 
385                 390                 395                 400 


Ala Ala Met Arg Leu Gly Ala Glu Cys Ala Arg Tyr Arg Ala Cys Thr 
                405                 410                 415     


Asp Ala Ala Tyr Ser Leu Leu Arg Glu Leu Gln Ala Glu Pro Gly Leu 
            420                 425                 430         


Pro Gly Ala Ala Ala Arg Lys Val Arg Asp Trp Leu Cys Ala Val Glu 
        435                 440                 445             


Gly Glu Arg Ser Ala Leu Ser Ser Ala Ser Gly Pro Asp Ser Gly Ile 
    450                 455                 460                 


Glu Ser Ala Ser Val Glu Asp Gln Ala Ala Gln Gly Ala Gly Gly Arg 
465                 470                 475                 480 


Lys Glu Asp Glu Gly Ala Gln Gln Leu Leu Thr Leu Gln Asn Gln Val 
                485                 490                 495     


Ala Arg Leu Glu Glu Glu Asn Arg Asp Phe Leu Ala Ala Leu Glu Asp 
            500                 505                 510         


Ala Met Glu Gln Tyr Lys Leu Gln Ser Asp Arg Leu Arg Glu Gln Gln 
        515                 520                 525             


Glu Glu Met Val Glu Leu Arg Leu Arg Leu Glu Leu Val Arg Pro Gly 
    530                 535                 540                 


Trp Gly Gly Pro Arg Leu Leu Asn Gly Leu Pro Pro Gly Ser Phe Val 
545                 550                 555                 560 


Pro Arg Pro His Thr Ala Pro Leu Gly Gly Ala His Ala His Val Leu 
                565                 570                 575     


Gly Met Val Pro Pro Ala Cys Leu Pro Gly Asp Glu Val Gly Ser Glu 
            580                 585                 590         


Gln Arg Gly Glu Gln Val Thr Asn Gly Arg Glu Ala Gly Ala Glu Leu 
        595                 600                 605             


Leu Thr Glu Val Asn Arg Leu Gly Ser Gly Ser Ser Ala Ala Ser Glu 
    610                 615                 620                 


Glu Glu Glu Glu Glu Glu Glu Pro Pro Arg Arg Thr Leu His Leu Arg 
625                 630                 635                 640 


Arg Asn Arg Ile Ser Asn Cys Ser Gln Arg Ala Gly Ala Arg Pro Gly 
                645                 650                 655     


Ser Leu Pro Glu Arg Lys Gly Pro Glu Leu Cys Leu Glu Glu Leu Asp 
            660                 665                 670         


Ala Ala Ile Pro Gly Ser Arg Ala Val Gly Gly Ser Lys Ala Arg Val 
        675                 680                 685             


Gln Ala Arg Gln Val Pro Pro Ala Thr Ala Ser Glu Trp Arg Leu Ala 
    690                 695                 700                 


Gln Ala Gln Gln Lys Ile Arg Glu Leu Ala Ile Asn Ile Arg Met Lys 
705                 710                 715                 720 


Glu Glu Leu Ile Gly Glu Leu Val Arg Thr Gly Lys Ala Ala Gln Ala 
                725                 730                 735     


Leu Asn Arg Gln His Ser Gln Arg Ile Arg Glu Leu Glu Gln Glu Ala 
            740                 745                 750         


Glu Gln Val Arg Ala Glu Leu Ser Glu Gly Gln Arg Gln Leu Arg Glu 
        755                 760                 765             


Leu Glu Gly Lys Glu Leu Gln Asp Ala Gly Glu Arg Ser Arg Leu Gln 
    770                 775                 780                 


Glu Phe Arg Arg Arg Val Ala Ala Ala Gln Ser Gln Val Gln Val Leu 
785                 790                 795                 800 


Lys Glu Lys Lys Gln Ala Thr Glu Arg Leu Val Ser Leu Ser Ala Gln 
                805                 810                 815     


Ser Glu Lys Arg Leu Gln Glu Leu Glu Arg Asn Val Gln Leu Met Arg 
            820                 825                 830         


Gln Gln Gln Gly Gln Leu Gln Arg Arg Leu Arg Glu Glu Thr Glu Gln 
        835                 840                 845             


Lys Arg Arg Leu Glu Ala Glu Met Ser Lys Arg Gln His Arg Val Lys 
    850                 855                 860                 


Glu Leu Glu Leu Lys His Glu Gln Gln Gln Lys Ile Leu Lys Ile Lys 
865                 870                 875                 880 


Thr Glu Glu Ile Ala Ala Phe Gln Arg Lys Arg Arg Ser Gly Ser Asn 
                885                 890                 895     


Gly Ser Val Val Ser Leu Glu Gln Gln Gln Lys Ile Glu Glu Gln Lys 
            900                 905                 910         


Lys Trp Leu Asp Gln Glu Met Glu Lys Val Leu Gln Gln Arg Arg Ala 
        915                 920                 925             


Leu Glu Glu Leu Gly Glu Glu Leu His Lys Arg Glu Ala Ile Leu Ala 
    930                 935                 940                 


Lys Lys Glu Ala Leu Met Gln Glu Lys Thr Gly Leu Glu Ser Lys Arg 
945                 950                 955                 960 


Leu Arg Ser Ser Gln Ala Leu Asn Glu Asp Ile Val Arg Val Ser Ser 
                965                 970                 975     


Arg Leu Glu His Leu Glu Lys Glu Leu Ser Glu Lys Ser Gly Gln Leu 
            980                 985                 990         


Arg Gln Gly Ser Ala Gln Ser Gln  Gln Gln Ile Arg Gly  Glu Ile Asp 
        995                 1000                 1005             


Ser Leu  Arg Gln Glu Lys Asp  Ser Leu Leu Lys Gln  Arg Leu Glu 
    1010                 1015                 1020             


Ile Asp  Gly Lys Leu Arg Gln  Gly Ser Leu Leu Ser  Pro Glu Glu 
    1025                 1030                 1035             


Glu Arg  Thr Leu Phe Gln Leu  Asp Glu Ala Ile Glu  Ala Leu Asp 
    1040                 1045                 1050             


Ala Ala  Ile Glu Tyr Lys Asn  Glu Ala Ile Thr Cys  Arg Gln Arg 
    1055                 1060                 1065             


Val Leu  Arg Ala Ser Ala Ser  Leu Leu Ser Gln Cys  Glu Met Asn 
    1070                 1075                 1080             


Leu Met  Ala Lys Leu Ser Tyr  Leu Ser Ser Ser Glu  Thr Arg Ala 
    1085                 1090                 1095             


Leu Leu  Cys Lys Tyr Phe Asp  Lys Val Val Thr Leu  Arg Glu Glu 
    1100                 1105                 1110             


Gln His  Gln Gln Gln Ile Ala  Phe Ser Glu Leu Glu  Met Gln Leu 
    1115                 1120                 1125             


Glu Glu  Gln Gln Arg Leu Val  Tyr Trp Leu Glu Val  Ala Leu Glu 
    1130                 1135                 1140             


Arg Gln  Arg Leu Glu Met Asp  Arg Gln Leu Thr Leu  Gln Gln Lys 
    1145                 1150                 1155             


Glu His  Glu Gln Asn Met Gln  Leu Leu Leu Gln Gln  Ser Arg Asp 
    1160                 1165                 1170             


His Leu  Gly Glu Gly Leu Ala  Asp Ser Arg Arg Gln  Tyr Glu Ala 
    1175                 1180                 1185             


Arg Ile  Gln Ala Leu Glu Lys  Glu Leu Gly Arg Tyr  Met Trp Ile 
    1190                 1195                 1200             


Asn Gln  Glu Leu Lys Gln Lys  Leu Gly Gly Val Asn  Ala Val Gly 
    1205                 1210                 1215             


His Ser  Arg Gly Gly Glu Lys  Arg Ser Leu Cys Ser  Glu Gly Arg 
    1220                 1225                 1230             


Gln Ala  Pro Gly Asn Glu Asp  Glu Leu His Leu Ala  Pro Glu Leu 
    1235                 1240                 1245             


Leu Trp  Leu Ser Pro Leu Thr  Glu Gly Ala Pro Arg  Thr Arg Glu 
    1250                 1255                 1260             


Glu Thr  Arg Asp Leu Val His  Ala Pro Leu Pro Leu  Thr Trp Lys 
    1265                 1270                 1275             


Arg Ser  Ser Leu Cys Gly Glu  Glu Gln Gly Ser Pro  Glu Glu Leu 
    1280                 1285                 1290             


Arg Gln  Arg Glu Ala Ala Glu  Pro Leu Val Gly Arg  Val Leu Pro 
    1295                 1300                 1305             


Val Gly  Glu Ala Gly Leu Pro  Trp Asn Phe Gly Pro  Leu Ser Lys 
    1310                 1315                 1320             


Pro Arg  Arg Glu Leu Arg Arg  Ala Ser Pro Gly Met  Ile Asp Val 
    1325                 1330                 1335             


Arg Lys  Asn Pro Leu 
    1340             


<210> 15
<211> 3014
<212> PRT
<213> Homo sapiens

<400> 15
Met Ala Pro Pro Pro Pro Pro Val Leu Pro Val Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Ala Ala Ala Leu Pro Ala Met Gly Leu Arg Ala Ala Ala Trp Glu 
            20                  25                  30          


Pro Arg Val Pro Gly Gly Thr Arg Ala Phe Ala Leu Arg Pro Gly Cys 
        35                  40                  45              


Thr Tyr Ala Val Gly Ala Ala Cys Thr Pro Arg Ala Pro Arg Glu Leu 
    50                  55                  60                  


Leu Asp Val Gly Arg Asp Gly Arg Leu Ala Gly Arg Arg Arg Val Ser 
65                  70                  75                  80  


Gly Ala Gly Arg Pro Leu Pro Leu Gln Val Arg Leu Val Ala Arg Ser 
                85                  90                  95      


Ala Pro Thr Ala Leu Ser Arg Arg Leu Arg Ala Arg Thr His Leu Pro 
            100                 105                 110         


Gly Cys Gly Ala Arg Ala Arg Leu Cys Gly Thr Gly Ala Arg Leu Cys 
        115                 120                 125             


Gly Ala Leu Cys Phe Pro Val Pro Gly Gly Cys Ala Ala Ala Gln His 
    130                 135                 140                 


Ser Ala Leu Ala Ala Pro Thr Thr Leu Pro Ala Cys Arg Cys Pro Pro 
145                 150                 155                 160 


Arg Pro Arg Pro Arg Cys Pro Gly Arg Pro Ile Cys Leu Pro Pro Gly 
                165                 170                 175     


Gly Ser Val Arg Leu Arg Leu Leu Cys Ala Leu Arg Arg Ala Ala Gly 
            180                 185                 190         


Ala Val Arg Val Gly Leu Ala Leu Glu Ala Ala Thr Ala Gly Thr Pro 
        195                 200                 205             


Ser Ala Ser Pro Ser Pro Ser Pro Pro Leu Pro Pro Asn Leu Pro Glu 
    210                 215                 220                 


Ala Arg Ala Gly Pro Ala Arg Arg Ala Arg Arg Gly Thr Ser Gly Arg 
225                 230                 235                 240 


Gly Ser Leu Lys Phe Pro Met Pro Asn Tyr Gln Val Ala Leu Phe Glu 
                245                 250                 255     


Asn Glu Pro Ala Gly Thr Leu Ile Leu Gln Leu His Ala His Tyr Thr 
            260                 265                 270         


Ile Glu Gly Glu Glu Glu Arg Val Ser Tyr Tyr Met Glu Gly Leu Phe 
        275                 280                 285             


Asp Glu Arg Ser Arg Gly Tyr Phe Arg Ile Asp Ser Ala Thr Gly Ala 
    290                 295                 300                 


Val Ser Thr Asp Ser Val Leu Asp Arg Glu Thr Lys Glu Thr His Val 
305                 310                 315                 320 


Leu Arg Val Lys Ala Val Asp Tyr Ser Thr Pro Pro Arg Ser Ala Thr 
                325                 330                 335     


Thr Tyr Ile Thr Val Leu Val Lys Asp Thr Asn Asp His Ser Pro Val 
            340                 345                 350         


Phe Glu Gln Ser Glu Tyr Arg Glu Arg Val Arg Glu Asn Leu Glu Val 
        355                 360                 365             


Gly Tyr Glu Val Leu Thr Ile Arg Ala Ser Asp Arg Asp Ser Pro Ile 
    370                 375                 380                 


Asn Ala Asn Leu Arg Tyr Arg Val Leu Gly Gly Ala Trp Asp Val Phe 
385                 390                 395                 400 


Gln Leu Asn Glu Ser Ser Gly Val Val Ser Thr Arg Ala Val Leu Asp 
                405                 410                 415     


Arg Glu Glu Ala Ala Glu Tyr Gln Leu Leu Val Glu Ala Asn Asp Gln 
            420                 425                 430         


Gly Arg Asn Pro Gly Pro Leu Ser Ala Thr Ala Thr Val Tyr Ile Glu 
        435                 440                 445             


Val Glu Asp Glu Asn Asp Asn Tyr Pro Gln Phe Ser Glu Gln Asn Tyr 
    450                 455                 460                 


Val Val Gln Val Pro Glu Asp Val Gly Leu Asn Thr Ala Val Leu Arg 
465                 470                 475                 480 


Val Gln Ala Thr Asp Arg Asp Gln Gly Gln Asn Ala Ala Ile His Tyr 
                485                 490                 495     


Ser Ile Leu Ser Gly Asn Val Ala Gly Gln Phe Tyr Leu His Ser Leu 
            500                 505                 510         


Ser Gly Ile Leu Asp Val Ile Asn Pro Leu Asp Phe Glu Asp Val Gln 
        515                 520                 525             


Lys Tyr Ser Leu Ser Ile Lys Ala Gln Asp Gly Gly Arg Pro Pro Leu 
    530                 535                 540                 


Ile Asn Ser Ser Gly Val Val Ser Val Gln Val Leu Asp Val Asn Asp 
545                 550                 555                 560 


Asn Glu Pro Ile Phe Val Ser Ser Pro Phe Gln Ala Thr Val Leu Glu 
                565                 570                 575     


Asn Val Pro Leu Gly Tyr Pro Val Val His Ile Gln Ala Val Asp Ala 
            580                 585                 590         


Asp Ser Gly Glu Asn Ala Arg Leu His Tyr Arg Leu Val Asp Thr Ala 
        595                 600                 605             


Ser Thr Phe Leu Gly Gly Gly Ser Ala Gly Pro Lys Asn Pro Ala Pro 
    610                 615                 620                 


Thr Pro Asp Phe Pro Phe Gln Ile His Asn Ser Ser Gly Trp Ile Thr 
625                 630                 635                 640 


Val Cys Ala Glu Leu Asp Arg Glu Glu Val Glu His Tyr Ser Phe Gly 
                645                 650                 655     


Val Glu Ala Val Asp His Gly Ser Pro Pro Met Ser Ser Ser Thr Ser 
            660                 665                 670         


Val Ser Ile Thr Val Leu Asp Val Asn Asp Asn Asp Pro Val Phe Thr 
        675                 680                 685             


Gln Pro Thr Tyr Glu Leu Arg Leu Asn Glu Asp Ala Ala Val Gly Ser 
    690                 695                 700                 


Ser Val Leu Thr Leu Gln Ala Arg Asp Arg Asp Ala Asn Ser Val Ile 
705                 710                 715                 720 


Thr Tyr Gln Leu Thr Gly Gly Asn Thr Arg Asn Arg Phe Ala Leu Ser 
                725                 730                 735     


Ser Gln Arg Gly Gly Gly Leu Ile Thr Leu Ala Leu Pro Leu Asp Tyr 
            740                 745                 750         


Lys Gln Glu Gln Gln Tyr Val Leu Ala Val Thr Ala Ser Asp Gly Thr 
        755                 760                 765             


Arg Ser His Thr Ala His Val Leu Ile Asn Val Thr Asp Ala Asn Thr 
    770                 775                 780                 


His Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Ser Val Ser Glu 
785                 790                 795                 800 


Asp Arg Pro Val Gly Thr Ser Ile Ala Thr Leu Ser Ala Asn Asp Glu 
                805                 810                 815     


Asp Thr Gly Glu Asn Ala Arg Ile Thr Tyr Val Ile Gln Asp Pro Val 
            820                 825                 830         


Pro Gln Phe Arg Ile Asp Pro Asp Ser Gly Thr Met Tyr Thr Met Met 
        835                 840                 845             


Glu Leu Asp Tyr Glu Asn Gln Val Ala Tyr Thr Leu Thr Ile Met Ala 
    850                 855                 860                 


Gln Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Thr Leu Glu Ile 
865                 870                 875                 880 


Leu Ile Leu Asp Ala Asn Asp Asn Ala Pro Gln Phe Leu Trp Asp Phe 
                885                 890                 895     


Tyr Gln Gly Ser Ile Phe Glu Asp Ala Pro Pro Ser Thr Ser Ile Leu 
            900                 905                 910         


Gln Val Ser Ala Thr Asp Arg Asp Ser Gly Pro Asn Gly Arg Leu Leu 
        915                 920                 925             


Tyr Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe Tyr Ile Glu 
    930                 935                 940                 


Pro Thr Ser Gly Val Ile Arg Thr Gln Arg Arg Leu Asp Arg Glu Asn 
945                 950                 955                 960 


Val Ala Val Tyr Asn Leu Trp Ala Leu Ala Val Asp Arg Gly Ser Pro 
                965                 970                 975     


Thr Pro Leu Ser Ala Ser Val Glu Ile Gln Val Thr Ile Leu Asp Ile 
            980                 985                 990         


Asn Asp Asn Ala Pro Met Phe Glu  Lys Asp Glu Leu Glu  Leu Phe Val 
        995                 1000                 1005             


Glu Glu  Asn Asn Pro Val Gly  Ser Val Val Ala Lys  Ile Arg Ala 
    1010                 1015                 1020             


Asn Asp  Pro Asp Glu Gly Pro  Asn Ala Gln Ile Met  Tyr Gln Ile 
    1025                 1030                 1035             


Val Glu  Gly Asp Met Arg His  Phe Phe Gln Leu Asp  Leu Leu Asn 
    1040                 1045                 1050             


Gly Asp  Leu Arg Ala Met Val  Glu Leu Asp Phe Glu  Val Arg Arg 
    1055                 1060                 1065             


Glu Tyr  Val Leu Val Val Gln  Ala Thr Ser Ala Pro  Leu Val Ser 
    1070                 1075                 1080             


Arg Ala  Thr Val His Ile Leu  Leu Val Asp Gln Asn  Asp Asn Pro 
    1085                 1090                 1095             


Pro Val  Leu Pro Asp Phe Gln  Ile Leu Phe Asn Asn  Tyr Val Thr 
    1100                 1105                 1110             


Asn Lys  Ser Asn Ser Phe Pro  Thr Gly Val Ile Gly  Cys Ile Pro 
    1115                 1120                 1125             


Ala His  Asp Pro Asp Val Ser  Asp Ser Leu Asn Tyr  Thr Phe Val 
    1130                 1135                 1140             


Gln Gly  Asn Glu Leu Arg Leu  Leu Leu Leu Asp Pro  Ala Thr Gly 
    1145                 1150                 1155             


Glu Leu  Gln Leu Ser Arg Asp  Leu Asp Asn Asn Arg  Pro Leu Glu 
    1160                 1165                 1170             


Ala Leu  Met Glu Val Ser Val  Ser Asp Gly Ile His  Ser Val Thr 
    1175                 1180                 1185             


Ala Phe  Cys Thr Leu Arg Val  Thr Ile Ile Thr Asp  Asp Met Leu 
    1190                 1195                 1200             


Thr Asn  Ser Ile Thr Val Arg  Leu Glu Asn Met Ser  Gln Glu Lys 
    1205                 1210                 1215             


Phe Leu  Ser Pro Leu Leu Ala  Leu Phe Val Glu Gly  Val Ala Ala 
    1220                 1225                 1230             


Val Leu  Ser Thr Thr Lys Asp  Asp Val Phe Val Phe  Asn Val Gln 
    1235                 1240                 1245             


Asn Asp  Thr Asp Val Ser Ser  Asn Ile Leu Asn Val  Thr Phe Ser 
    1250                 1255                 1260             


Ala Leu  Leu Pro Gly Gly Val  Arg Gly Gln Phe Phe  Pro Ser Glu 
    1265                 1270                 1275             


Asp Leu  Gln Glu Gln Ile Tyr  Leu Asn Arg Thr Leu  Leu Thr Thr 
    1280                 1285                 1290             


Ile Ser  Thr Gln Arg Val Leu  Pro Phe Asp Asp Asn  Ile Cys Leu 
    1295                 1300                 1305             


Arg Glu  Pro Cys Glu Asn Tyr  Met Lys Cys Val Ser  Val Leu Arg 
    1310                 1315                 1320             


Phe Asp  Ser Ser Ala Pro Phe  Leu Ser Ser Thr Thr  Val Leu Phe 
    1325                 1330                 1335             


Arg Pro  Ile His Pro Ile Asn  Gly Leu Arg Cys Arg  Cys Pro Pro 
    1340                 1345                 1350             


Gly Phe  Thr Gly Asp Tyr Cys  Glu Thr Glu Ile Asp  Leu Cys Tyr 
    1355                 1360                 1365             


Ser Asp  Pro Cys Gly Ala Asn  Gly Arg Cys Arg Ser  Arg Glu Gly 
    1370                 1375                 1380             


Gly Tyr  Thr Cys Glu Cys Phe  Glu Asp Phe Thr Gly  Glu His Cys 
    1385                 1390                 1395             


Glu Val  Asp Ala Arg Ser Gly  Arg Cys Ala Asn Gly  Val Cys Lys 
    1400                 1405                 1410             


Asn Gly  Gly Thr Cys Val Asn  Leu Leu Ile Gly Gly  Phe His Cys 
    1415                 1420                 1425             


Val Cys  Pro Pro Gly Glu Tyr  Glu Arg Pro Tyr Cys  Glu Val Thr 
    1430                 1435                 1440             


Thr Arg  Ser Phe Pro Pro Gln  Ser Phe Val Thr Phe  Arg Gly Leu 
    1445                 1450                 1455             


Arg Gln  Arg Phe His Phe Thr  Ile Ser Leu Thr Phe  Ala Thr Gln 
    1460                 1465                 1470             


Glu Arg  Asn Gly Leu Leu Leu  Tyr Asn Gly Arg Phe  Asn Glu Lys 
    1475                 1480                 1485             


His Asp  Phe Ile Ala Leu Glu  Ile Val Asp Glu Gln  Val Gln Leu 
    1490                 1495                 1500             


Thr Phe  Ser Ala Gly Glu Thr  Thr Thr Thr Val Ala  Pro Lys Val 
    1505                 1510                 1515             


Pro Ser  Gly Val Ser Asp Gly  Arg Trp His Ser Val  Gln Val Gln 
    1520                 1525                 1530             


Tyr Tyr  Asn Lys Pro Asn Ile  Gly His Leu Gly Leu  Pro His Gly 
    1535                 1540                 1545             


Pro Ser  Gly Glu Lys Met Ala  Val Val Thr Val Asp  Asp Cys Asp 
    1550                 1555                 1560             


Thr Thr  Met Ala Val Arg Phe  Gly Lys Asp Ile Gly  Asn Tyr Ser 
    1565                 1570                 1575             


Cys Ala  Ala Gln Gly Thr Gln  Thr Gly Ser Lys Lys  Ser Leu Asp 
    1580                 1585                 1590             


Leu Thr  Gly Pro Leu Leu Leu  Gly Gly Val Pro Asn  Leu Pro Glu 
    1595                 1600                 1605             


Asp Phe  Pro Val His Asn Arg  Gln Phe Val Gly Cys  Met Arg Asn 
    1610                 1615                 1620             


Leu Ser  Val Asp Gly Lys Asn  Val Asp Met Ala Gly  Phe Ile Ala 
    1625                 1630                 1635             


Asn Asn  Gly Thr Arg Glu Gly  Cys Ala Ala Arg Arg  Asn Phe Cys 
    1640                 1645                 1650             


Asp Gly  Arg Arg Cys Gln Asn  Gly Gly Thr Cys Val  Asn Arg Trp 
    1655                 1660                 1665             


Asn Met  Tyr Leu Cys Glu Cys  Pro Leu Arg Phe Gly  Gly Lys Asn 
    1670                 1675                 1680             


Cys Glu  Gln Ala Met Pro His  Pro Gln Leu Phe Ser  Gly Glu Ser 
    1685                 1690                 1695             


Val Val  Ser Trp Ser Asp Leu  Asn Ile Ile Ile Ser  Val Pro Trp 
    1700                 1705                 1710             


Tyr Leu  Gly Leu Met Phe Arg  Thr Arg Lys Glu Asp  Ser Val Leu 
    1715                 1720                 1725             


Met Glu  Ala Thr Ser Gly Gly  Pro Thr Ser Phe Arg  Leu Gln Ile 
    1730                 1735                 1740             


Leu Asn  Asn Tyr Leu Gln Phe  Glu Val Ser His Gly  Pro Ser Asp 
    1745                 1750                 1755             


Val Glu  Ser Val Met Leu Ser  Gly Leu Arg Val Thr  Asp Gly Glu 
    1760                 1765                 1770             


Trp His  His Leu Leu Ile Glu  Leu Lys Asn Val Lys  Glu Asp Ser 
    1775                 1780                 1785             


Glu Met  Lys His Leu Val Thr  Met Thr Leu Asp Tyr  Gly Met Asp 
    1790                 1795                 1800             


Gln Asn  Lys Ala Asp Ile Gly  Gly Met Leu Pro Gly  Leu Thr Val 
    1805                 1810                 1815             


Arg Ser  Val Val Val Gly Gly  Ala Ser Glu Asp Lys  Val Ser Val 
    1820                 1825                 1830             


Arg Arg  Gly Phe Arg Gly Cys  Met Gln Gly Val Arg  Met Gly Gly 
    1835                 1840                 1845             


Thr Pro  Thr Asn Val Ala Thr  Leu Asn Met Asn Asn  Ala Leu Lys 
    1850                 1855                 1860             


Val Arg  Val Lys Asp Gly Cys  Asp Val Asp Asp Pro  Cys Thr Ser 
    1865                 1870                 1875             


Ser Pro  Cys Pro Pro Asn Ser  Arg Cys His Asp Ala  Trp Glu Asp 
    1880                 1885                 1890             


Tyr Ser  Cys Val Cys Asp Lys  Gly Tyr Leu Gly Ile  Asn Cys Val 
    1895                 1900                 1905             


Asp Ala  Cys His Leu Asn Pro  Cys Glu Asn Met Gly  Ala Cys Val 
    1910                 1915                 1920             


Arg Ser  Pro Gly Ser Pro Gln  Gly Tyr Val Cys Glu  Cys Gly Pro 
    1925                 1930                 1935             


Ser His  Tyr Gly Pro Tyr Cys  Glu Asn Lys Leu Asp  Leu Pro Cys 
    1940                 1945                 1950             


Pro Arg  Gly Trp Trp Gly Asn  Pro Val Cys Gly Pro  Cys His Cys 
    1955                 1960                 1965             


Ala Val  Ser Lys Gly Phe Asp  Pro Asp Cys Asn Lys  Thr Asn Gly 
    1970                 1975                 1980             


Gln Cys  Gln Cys Lys Glu Asn  Tyr Tyr Lys Leu Leu  Ala Gln Asp 
    1985                 1990                 1995             


Thr Cys  Leu Pro Cys Asp Cys  Phe Pro His Gly Ser  His Ser Arg 
    2000                 2005                 2010             


Thr Cys  Asp Met Ala Thr Gly  Gln Cys Ala Cys Lys  Pro Gly Val 
    2015                 2020                 2025             


Ile Gly  Arg Gln Cys Asn Arg  Cys Asp Asn Pro Phe  Ala Glu Val 
    2030                 2035                 2040             


Thr Thr  Leu Gly Cys Glu Val  Ile Tyr Asn Gly Cys  Pro Lys Ala 
    2045                 2050                 2055             


Phe Glu  Ala Gly Ile Trp Trp  Pro Gln Thr Lys Phe  Gly Gln Pro 
    2060                 2065                 2070             


Ala Ala  Val Pro Cys Pro Lys  Gly Ser Val Gly Asn  Ala Val Arg 
    2075                 2080                 2085             


His Cys  Ser Gly Glu Lys Gly  Trp Leu Pro Pro Glu  Leu Phe Asn 
    2090                 2095                 2100             


Cys Thr  Thr Ile Ser Phe Val  Asp Leu Arg Ala Met  Asn Glu Lys 
    2105                 2110                 2115             


Leu Ser  Arg Asn Glu Thr Gln  Val Asp Gly Ala Arg  Ala Leu Gln 
    2120                 2125                 2130             


Leu Val  Arg Ala Leu Arg Ser  Ala Thr Gln His Thr  Gly Thr Leu 
    2135                 2140                 2145             


Phe Gly  Asn Asp Val Arg Thr  Ala Tyr Gln Leu Leu  Gly His Val 
    2150                 2155                 2160             


Leu Gln  His Glu Ser Trp Gln  Gln Gly Phe Asp Leu  Ala Ala Thr 
    2165                 2170                 2175             


Gln Asp  Ala Asp Phe His Glu  Asp Val Ile His Ser  Gly Ser Ala 
    2180                 2185                 2190             


Leu Leu  Ala Pro Ala Thr Arg  Ala Ala Trp Glu Gln  Ile Gln Arg 
    2195                 2200                 2205             


Ser Glu  Gly Gly Thr Ala Gln  Leu Leu Arg Arg Leu  Glu Gly Tyr 
    2210                 2215                 2220             


Phe Ser  Asn Val Ala Arg Asn  Val Arg Arg Thr Tyr  Leu Arg Pro 
    2225                 2230                 2235             


Phe Val  Ile Val Thr Ala Asn  Met Ile Leu Ala Val  Asp Ile Phe 
    2240                 2245                 2250             


Asp Lys  Phe Asn Phe Thr Gly  Ala Arg Val Pro Arg  Phe Asp Thr 
    2255                 2260                 2265             


Ile His  Glu Glu Phe Pro Arg  Glu Leu Glu Ser Ser  Val Ser Phe 
    2270                 2275                 2280             


Pro Ala  Asp Phe Phe Arg Pro  Pro Glu Glu Lys Glu  Gly Pro Leu 
    2285                 2290                 2295             


Leu Arg  Pro Ala Gly Arg Arg  Thr Thr Pro Gln Thr  Thr Arg Pro 
    2300                 2305                 2310             


Gly Pro  Gly Thr Glu Arg Glu  Ala Pro Ile Ser Arg  Arg Arg Arg 
    2315                 2320                 2325             


His Pro  Asp Asp Ala Gly Gln  Phe Ala Val Ala Leu  Val Ile Ile 
    2330                 2335                 2340             


Tyr Arg  Thr Leu Gly Gln Leu  Leu Pro Glu Arg Tyr  Asp Pro Asp 
    2345                 2350                 2355             


Arg Arg  Ser Leu Arg Leu Pro  His Arg Pro Ile Ile  Asn Thr Pro 
    2360                 2365                 2370             


Met Val  Ser Thr Leu Val Tyr  Ser Glu Gly Ala Pro  Leu Pro Arg 
    2375                 2380                 2385             


Pro Leu  Glu Arg Pro Val Leu  Val Glu Phe Ala Leu  Leu Glu Val 
    2390                 2395                 2400             


Glu Glu  Arg Thr Lys Pro Val  Cys Val Phe Trp Asn  His Ser Leu 
    2405                 2410                 2415             


Ala Val  Gly Gly Thr Gly Gly  Trp Ser Ala Arg Gly  Cys Glu Leu 
    2420                 2425                 2430             


Leu Ser  Arg Asn Arg Thr His  Val Ala Cys Gln Cys  Ser His Thr 
    2435                 2440                 2445             


Ala Ser  Phe Ala Val Leu Met  Asp Ile Ser Arg Arg  Glu Asn Gly 
    2450                 2455                 2460             


Glu Val  Leu Pro Leu Lys Ile  Val Thr Tyr Ala Ala  Val Ser Leu 
    2465                 2470                 2475             


Ser Leu  Ala Ala Leu Leu Val  Ala Phe Val Leu Leu  Ser Leu Val 
    2480                 2485                 2490             


Arg Met  Leu Arg Ser Asn Leu  His Ser Ile His Lys  His Leu Ala 
    2495                 2500                 2505             


Val Ala  Leu Phe Leu Ser Gln  Leu Val Phe Val Ile  Gly Ile Asn 
    2510                 2515                 2520             


Gln Thr  Glu Asn Pro Phe Leu  Cys Thr Val Val Ala  Ile Leu Leu 
    2525                 2530                 2535             


His Tyr  Ile Tyr Met Ser Thr  Phe Ala Trp Thr Leu  Val Glu Ser 
    2540                 2545                 2550             


Leu His  Val Tyr Arg Met Leu  Thr Glu Val Arg Asn  Ile Asp Thr 
    2555                 2560                 2565             


Gly Pro  Met Arg Phe Tyr Tyr  Val Val Gly Trp Gly  Ile Pro Ala 
    2570                 2575                 2580             


Ile Val  Thr Gly Leu Ala Val  Gly Leu Asp Pro Gln  Gly Tyr Gly 
    2585                 2590                 2595             


Asn Pro  Asp Phe Cys Trp Leu  Ser Leu Gln Asp Thr  Leu Ile Trp 
    2600                 2605                 2610             


Ser Phe  Ala Gly Pro Ile Gly  Ala Val Ile Ile Ile  Asn Thr Val 
    2615                 2620                 2625             


Thr Ser  Val Leu Ser Ala Lys  Val Ser Cys Gln Arg  Lys His His 
    2630                 2635                 2640             


Tyr Tyr  Gly Lys Lys Gly Ile  Val Ser Leu Leu Arg  Thr Ala Phe 
    2645                 2650                 2655             


Leu Leu  Leu Leu Leu Ile Ser  Ala Thr Trp Leu Leu  Gly Leu Leu 
    2660                 2665                 2670             


Ala Val  Asn Arg Asp Ala Leu  Ser Phe His Tyr Leu  Phe Ala Ile 
    2675                 2680                 2685             


Phe Ser  Gly Leu Gln Gly Pro  Phe Val Leu Leu Phe  His Cys Val 
    2690                 2695                 2700             


Leu Asn  Gln Glu Val Arg Lys  His Leu Lys Gly Val  Leu Gly Gly 
    2705                 2710                 2715             


Arg Lys  Leu His Leu Glu Asp  Ser Ala Thr Thr Arg  Ala Thr Leu 
    2720                 2725                 2730             


Leu Thr  Arg Ser Leu Asn Cys  Asn Thr Thr Phe Gly  Asp Gly Pro 
    2735                 2740                 2745             


Asp Met  Leu Arg Thr Asp Leu  Gly Glu Ser Thr Ala  Ser Leu Asp 
    2750                 2755                 2760             


Ser Ile  Val Arg Asp Glu Gly  Ile Gln Lys Leu Gly  Val Ser Ser 
    2765                 2770                 2775             


Gly Leu  Val Arg Gly Ser His  Gly Glu Pro Asp Ala  Ser Leu Met 
    2780                 2785                 2790             


Pro Arg  Ser Cys Lys Asp Pro  Pro Gly His Asp Ser  Asp Ser Asp 
    2795                 2800                 2805             


Ser Glu  Leu Ser Leu Asp Glu  Gln Ser Ser Ser Tyr  Ala Ser Ser 
    2810                 2815                 2820             


His Ser  Ser Asp Ser Glu Asp  Asp Gly Val Gly Ala  Glu Glu Lys 
    2825                 2830                 2835             


Trp Asp  Pro Ala Arg Gly Ala  Val His Ser Thr Pro  Lys Gly Asp 
    2840                 2845                 2850             


Ala Val  Ala Asn His Val Pro  Ala Gly Trp Pro Asp  Gln Ser Leu 
    2855                 2860                 2865             


Ala Glu  Ser Asp Ser Glu Asp  Pro Ser Gly Lys Pro  Arg Leu Lys 
    2870                 2875                 2880             


Val Glu  Thr Lys Val Ser Val  Glu Leu His Arg Glu  Glu Gln Gly 
    2885                 2890                 2895             


Ser His  Arg Gly Glu Tyr Pro  Pro Asp Gln Glu Ser  Gly Gly Ala 
    2900                 2905                 2910             


Ala Arg  Leu Ala Ser Ser Gln  Pro Pro Glu Gln Arg  Lys Gly Ile 
    2915                 2920                 2925             


Leu Lys  Asn Lys Val Thr Tyr  Pro Pro Pro Leu Thr  Leu Thr Glu 
    2930                 2935                 2940             


Gln Thr  Leu Lys Gly Arg Leu  Arg Glu Lys Leu Ala  Asp Cys Glu 
    2945                 2950                 2955             


Gln Ser  Pro Thr Ser Ser Arg  Thr Ser Ser Leu Gly  Ser Gly Gly 
    2960                 2965                 2970             


Pro Asp  Cys Ala Ile Thr Val  Lys Ser Pro Gly Arg  Glu Pro Gly 
    2975                 2980                 2985             


Arg Asp  His Leu Asn Gly Val  Ala Met Asn Val Arg  Thr Gly Ser 
    2990                 2995                 3000             


Ala Gln  Ala Asp Gly Ser Asp  Ser Glu Lys Pro 
    3005                 3010                 


<210> 16
<211> 1397
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Pro Pro Pro Pro Pro Val Leu Pro Val Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Ala Ala Ala Leu Pro Ala Met Gly Leu Arg Ala Ala Ala Trp Glu 
            20                  25                  30          


Pro Arg Val Pro Gly Gly Thr Arg Ala Phe Ala Leu Arg Pro Gly Cys 
        35                  40                  45              


Thr Tyr Ala Val Gly Ala Ala Cys Thr Pro Arg Ala Pro Arg Glu Leu 
    50                  55                  60                  


Leu Asp Val Gly Arg Asp Gly Arg Leu Ala Gly Arg Arg Arg Val Ser 
65                  70                  75                  80  


Gly Ala Gly Arg Pro Leu Pro Leu Gln Val Arg Leu Val Ala Arg Ser 
                85                  90                  95      


Ala Pro Thr Ala Leu Ser Arg Arg Leu Arg Ala Arg Thr His Leu Pro 
            100                 105                 110         


Gly Cys Gly Ala Arg Ala Arg Leu Cys Gly Thr Gly Ala Arg Leu Cys 
        115                 120                 125             


Gly Ala Leu Cys Phe Pro Val Pro Gly Gly Cys Ala Ala Ala Gln His 
    130                 135                 140                 


Ser Ala Leu Ala Ala Pro Thr Thr Leu Pro Ala Cys Arg Cys Pro Pro 
145                 150                 155                 160 


Arg Pro Arg Pro Arg Cys Pro Gly Arg Pro Ile Cys Leu Pro Pro Gly 
                165                 170                 175     


Gly Ser Val Arg Leu Arg Leu Leu Cys Ala Leu Arg Arg Ala Ala Gly 
            180                 185                 190         


Ala Val Arg Val Gly Leu Ala Leu Glu Ala Ala Thr Ala Gly Thr Pro 
        195                 200                 205             


Ser Ala Ser Pro Ser Pro Ser Pro Pro Leu Pro Pro Asn Leu Pro Glu 
    210                 215                 220                 


Ala Arg Ala Gly Pro Ala Arg Arg Ala Arg Arg Gly Thr Ser Gly Arg 
225                 230                 235                 240 


Gly Ser Leu Lys Phe Pro Met Pro Asn Tyr Gln Val Ala Leu Phe Glu 
                245                 250                 255     


Asn Glu Pro Ala Gly Thr Leu Ile Leu Gln Leu His Ala His Tyr Thr 
            260                 265                 270         


Ile Glu Gly Glu Glu Glu Arg Val Ser Tyr Tyr Met Glu Gly Leu Phe 
        275                 280                 285             


Asp Glu Arg Ser Arg Gly Tyr Phe Arg Ile Asp Ser Ala Thr Gly Ala 
    290                 295                 300                 


Val Ser Thr Asp Ser Val Leu Asp Arg Glu Thr Lys Glu Thr His Val 
305                 310                 315                 320 


Leu Arg Val Lys Ala Val Asp Tyr Ser Thr Pro Pro Arg Ser Ala Thr 
                325                 330                 335     


Thr Tyr Ile Thr Val Leu Val Lys Asp Thr Asn Asp His Ser Pro Val 
            340                 345                 350         


Phe Glu Gln Ser Glu Tyr Arg Glu Arg Val Arg Glu Asn Leu Glu Val 
        355                 360                 365             


Gly Tyr Glu Val Leu Thr Ile Arg Ala Ser Asp Arg Asp Ser Pro Ile 
    370                 375                 380                 


Asn Ala Asn Leu Arg Tyr Arg Val Leu Gly Gly Ala Trp Asp Val Phe 
385                 390                 395                 400 


Gln Leu Asn Glu Ser Ser Gly Val Val Ser Thr Arg Ala Val Leu Asp 
                405                 410                 415     


Arg Glu Glu Ala Ala Glu Tyr Gln Leu Leu Val Glu Ala Asn Asp Gln 
            420                 425                 430         


Gly Arg Asn Pro Gly Pro Leu Ser Ala Thr Ala Thr Val Tyr Ile Glu 
        435                 440                 445             


Val Glu Asp Glu Asn Asp Asn Tyr Pro Gln Phe Ser Glu Gln Asn Tyr 
    450                 455                 460                 


Val Val Gln Val Pro Glu Asp Val Gly Leu Asn Thr Ala Val Leu Arg 
465                 470                 475                 480 


Val Gln Ala Thr Asp Arg Asp Gln Gly Gln Asn Ala Ala Ile His Tyr 
                485                 490                 495     


Ser Ile Leu Ser Gly Asn Val Ala Gly Gln Phe Tyr Leu His Ser Leu 
            500                 505                 510         


Ser Gly Ile Leu Asp Val Ile Asn Pro Leu Asp Phe Glu Asp Val Gln 
        515                 520                 525             


Lys Tyr Ser Leu Ser Ile Lys Ala Gln Asp Gly Gly Arg Pro Pro Leu 
    530                 535                 540                 


Ile Asn Ser Ser Gly Val Val Ser Val Gln Val Leu Asp Val Asn Asp 
545                 550                 555                 560 


Asn Glu Pro Ile Phe Val Ser Ser Pro Phe Gln Ala Thr Val Leu Glu 
                565                 570                 575     


Asn Val Pro Leu Gly Tyr Pro Val Val His Ile Gln Ala Val Asp Ala 
            580                 585                 590         


Asp Ser Gly Glu Asn Ala Arg Leu His Tyr Arg Leu Val Asp Thr Ala 
        595                 600                 605             


Ser Thr Phe Leu Gly Gly Gly Ser Ala Gly Pro Lys Asn Pro Ala Pro 
    610                 615                 620                 


Thr Pro Asp Phe Pro Phe Gln Ile His Asn Ser Ser Gly Trp Ile Thr 
625                 630                 635                 640 


Val Cys Ala Glu Leu Asp Arg Glu Glu Val Glu His Tyr Ser Phe Gly 
                645                 650                 655     


Val Glu Ala Val Asp His Gly Ser Pro Pro Met Ser Ser Ser Thr Ser 
            660                 665                 670         


Val Ser Ile Thr Val Leu Asp Val Asn Asp Asn Asp Pro Val Phe Thr 
        675                 680                 685             


Gln Pro Thr Tyr Glu Leu Arg Leu Asn Glu Asp Ala Ala Val Gly Ser 
    690                 695                 700                 


Ser Val Leu Thr Leu Gln Ala Arg Asp Arg Asp Ala Asn Ser Val Ile 
705                 710                 715                 720 


Thr Tyr Gln Leu Thr Gly Gly Asn Thr Arg Asn Arg Phe Ala Leu Ser 
                725                 730                 735     


Ser Gln Arg Gly Gly Gly Leu Ile Thr Leu Ala Leu Pro Leu Asp Tyr 
            740                 745                 750         


Lys Gln Glu Gln Gln Tyr Val Leu Ala Val Thr Ala Ser Asp Gly Thr 
        755                 760                 765             


Arg Ser His Thr Ala His Val Leu Ile Asn Val Thr Asp Ala Asn Thr 
    770                 775                 780                 


His Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Ser Val Ser Glu 
785                 790                 795                 800 


Asp Arg Pro Val Gly Thr Ser Ile Ala Thr Leu Ser Ala Asn Asp Glu 
                805                 810                 815     


Asp Thr Gly Glu Asn Ala Arg Ile Thr Tyr Val Ile Gln Asp Pro Val 
            820                 825                 830         


Pro Gln Phe Arg Ile Asp Pro Asp Ser Gly Thr Met Tyr Thr Met Met 
        835                 840                 845             


Glu Leu Asp Tyr Glu Asn Gln Val Ala Tyr Thr Leu Thr Ile Met Ala 
    850                 855                 860                 


Gln Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Thr Leu Glu Ile 
865                 870                 875                 880 


Leu Ile Leu Asp Ala Asn Asp Asn Ala Pro Gln Phe Leu Trp Asp Phe 
                885                 890                 895     


Tyr Gln Gly Ser Ile Phe Glu Asp Ala Pro Pro Ser Thr Ser Ile Leu 
            900                 905                 910         


Gln Val Ser Ala Thr Asp Arg Asp Ser Gly Pro Asn Gly Arg Leu Leu 
        915                 920                 925             


Tyr Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe Tyr Ile Glu 
    930                 935                 940                 


Pro Thr Ser Gly Val Ile Arg Thr Gln Arg Arg Leu Asp Arg Glu Asn 
945                 950                 955                 960 


Val Ala Val Tyr Asn Leu Trp Ala Leu Ala Val Asp Arg Gly Ser Pro 
                965                 970                 975     


Thr Pro Leu Ser Ala Ser Val Glu Ile Gln Val Thr Ile Leu Asp Ile 
            980                 985                 990         


Asn Asp Asn Ala Pro Met Phe Glu  Lys Asp Glu Leu Glu  Leu Phe Val 
        995                 1000                 1005             


Glu Glu  Asn Asn Pro Val Gly  Ser Val Val Ala Lys  Ile Arg Ala 
    1010                 1015                 1020             


Asn Asp  Pro Asp Glu Gly Pro  Asn Ala Gln Ile Met  Tyr Gln Ile 
    1025                 1030                 1035             


Val Glu  Gly Asp Met Arg His  Phe Phe Gln Leu Asp  Leu Leu Asn 
    1040                 1045                 1050             


Gly Asp  Leu Arg Ala Met Val  Glu Leu Asp Phe Glu  Val Arg Arg 
    1055                 1060                 1065             


Glu Tyr  Val Leu Val Val Gln  Ala Thr Ser Ala Pro  Leu Val Ser 
    1070                 1075                 1080             


Arg Ala  Thr Val His Ile Leu  Leu Val Asp Gln Asn  Asp Asn Pro 
    1085                 1090                 1095             


Pro Val  Leu Pro Asp Phe Gln  Ile Leu Phe Asn Asn  Tyr Val Thr 
    1100                 1105                 1110             


Asn Lys  Ser Asn Ser Phe Pro  Thr Gly Val Ile Gly  Cys Ile Pro 
    1115                 1120                 1125             


Ala His  Asp Pro Asp Val Ser  Asp Ser Leu Asn Tyr  Thr Phe Val 
    1130                 1135                 1140             


Gln Gly  Asn Glu Leu Arg Leu  Leu Leu Leu Asp Pro  Ala Thr Gly 
    1145                 1150                 1155             


Glu Leu  Gln Leu Ser Arg Asp  Leu Asp Asn Asn Arg  Pro Leu Glu 
    1160                 1165                 1170             


Ala Leu  Met Glu Val Ser Val  Ser Asp Gly Ile His  Ser Val Thr 
    1175                 1180                 1185             


Ala Phe  Cys Thr Leu Arg Val  Thr Ile Ile Thr Asp  Asp Met Leu 
    1190                 1195                 1200             


Thr Asn  Ser Ile Thr Val Arg  Leu Glu Asn Met Ser  Gln Glu Lys 
    1205                 1210                 1215             


Phe Leu  Ser Pro Leu Leu Ala  Leu Phe Val Glu Gly  Val Ala Ala 
    1220                 1225                 1230             


Val Leu  Ser Thr Thr Lys Asp  Asp Val Phe Val Phe  Asn Val Gln 
    1235                 1240                 1245             


Asn Asp  Thr Asp Val Ser Ser  Asn Ile Leu Asn Val  Thr Phe Ser 
    1250                 1255                 1260             


Ala Leu  Leu Pro Gly Gly Val  Arg Gly Gln Phe Phe  Pro Ser Glu 
    1265                 1270                 1275             


Asp Leu  Gln Glu Gln Ile Tyr  Leu Asn Arg Thr Leu  Leu Thr Thr 
    1280                 1285                 1290             


Ile Ser  Thr Gln Arg Val Leu  Pro Phe Asp Asp Asn  Ile Cys Leu 
    1295                 1300                 1305             


Arg Glu  Pro Cys Glu Asn Tyr  Met Lys Cys Val Ser  Val Leu Arg 
    1310                 1315                 1320             


Phe Asp  Ser Ser Ala Pro Phe  Leu Ser Ser Thr Thr  Val Leu Phe 
    1325                 1330                 1335             


Arg Pro  Ile His Pro Ile Asn  Gly Leu Arg Cys Arg  Cys Pro Pro 
    1340                 1345                 1350             


Gly Phe  Thr Gly Asp Tyr Cys  Glu Thr Glu Ile Asp  Leu Cys Tyr 
    1355                 1360                 1365             


Ser Asp  Pro Cys Gly Ala Asn  Gly Arg Cys Arg Ser  Arg Glu Gly 
    1370                 1375                 1380             


Gly Tyr  Thr Cys Glu Cys Phe  Glu Asp Phe Thr Glu  Ile Ser 
    1385                 1390                 1395         


<210> 17
<211> 772
<212> PRT
<213> Homo sapiens

<400> 17
Met Tyr Pro Gln Gly Arg His Pro Ala Pro His Gln Pro Gly Gln Pro 
1               5                   10                  15      


Gly Phe Lys Phe Thr Val Ala Glu Ser Cys Asp Arg Ile Lys Asp Glu 
            20                  25                  30          


Phe Gln Phe Leu Gln Ala Gln Tyr His Ser Leu Lys Val Glu Tyr Asp 
        35                  40                  45              


Lys Leu Ala Asn Glu Lys Thr Glu Met Gln Arg His Tyr Val Met Tyr 
    50                  55                  60                  


Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Thr Glu 
65                  70                  75                  80  


Ile Ala Lys Arg Leu Asn Thr Ile Leu Ala Gln Ile Met Pro Phe Leu 
                85                  90                  95      


Ser Gln Glu His Gln Gln Gln Val Ala Gln Ala Val Glu Arg Ala Lys 
            100                 105                 110         


Gln Val Thr Met Thr Glu Leu Asn Ala Ile Ile Gly Gln Gln Gln Leu 
        115                 120                 125             


Gln Ala Gln His Leu Ser His Ala Thr His Gly Pro Pro Val Gln Leu 
    130                 135                 140                 


Pro Pro His Pro Ser Gly Leu Gln Pro Pro Gly Ile Pro Pro Val Thr 
145                 150                 155                 160 


Gly Ser Ser Ser Gly Leu Leu Ala Leu Gly Ala Leu Gly Ser Gln Ala 
                165                 170                 175     


His Leu Thr Val Lys Asp Glu Lys Asn His His Glu Leu Asp His Arg 
            180                 185                 190         


Glu Arg Glu Ser Ser Ala Asn Asn Ser Val Ser Pro Ser Glu Ser Leu 
        195                 200                 205             


Arg Ala Ser Glu Lys His Arg Gly Ser Ala Asp Tyr Ser Met Glu Ala 
    210                 215                 220                 


Lys Lys Arg Lys Ala Glu Glu Lys Asp Ser Leu Ser Arg Tyr Asp Ser 
225                 230                 235                 240 


Asp Gly Asp Lys Ser Asp Asp Leu Val Val Asp Val Ser Asn Glu Asp 
                245                 250                 255     


Pro Ala Thr Pro Arg Val Ser Pro Ala His Ser Pro Pro Glu Asn Gly 
            260                 265                 270         


Leu Asp Lys Ala Arg Ser Leu Lys Lys Asp Ala Pro Thr Ser Pro Ala 
        275                 280                 285             


Ser Val Ala Ser Ser Ser Ser Thr Pro Ser Ser Lys Thr Lys Asp Leu 
    290                 295                 300                 


Gly His Asn Asp Lys Ser Ser Thr Pro Gly Leu Lys Ser Asn Thr Pro 
305                 310                 315                 320 


Thr Pro Arg Asn Asp Ala Pro Thr Pro Gly Thr Ser Thr Thr Pro Gly 
                325                 330                 335     


Leu Arg Ser Met Pro Gly Lys Pro Pro Gly Met Asp Pro Ile Gly Ile 
            340                 345                 350         


Met Ala Ser Ala Leu Arg Thr Pro Ile Ser Ile Thr Ser Ser Tyr Ala 
        355                 360                 365             


Ala Pro Phe Ala Met Met Ser His His Glu Met Asn Gly Ser Leu Thr 
    370                 375                 380                 


Ser Pro Gly Ala Tyr Ala Gly Leu His Asn Ile Pro Pro Gln Met Ser 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Tyr Gly Arg Ser Pro Met Val 
                405                 410                 415     


Ser Phe Gly Ala Val Gly Phe Asp Pro His Pro Pro Met Arg Ala Thr 
            420                 425                 430         


Gly Leu Pro Ser Ser Leu Ala Ser Ile Pro Gly Gly Lys Pro Ala Tyr 
        435                 440                 445             


Ser Phe His Val Ser Ala Asp Gly Gln Met Gln Pro Val Pro Phe Pro 
    450                 455                 460                 


His Asp Ala Leu Ala Gly Pro Gly Ile Pro Arg His Ala Arg Gln Ile 
465                 470                 475                 480 


Asn Thr Leu Ser His Gly Glu Val Val Cys Ala Val Thr Ile Ser Asn 
                485                 490                 495     


Pro Thr Arg His Val Tyr Thr Gly Gly Lys Gly Cys Val Lys Ile Trp 
            500                 505                 510         


Asp Ile Ser Gln Pro Gly Ser Lys Ser Pro Ile Ser Gln Leu Asp Cys 
        515                 520                 525             


Leu Asn Arg Asp Asn Tyr Ile Arg Ser Cys Lys Leu Leu Pro Asp Gly 
    530                 535                 540                 


Arg Thr Leu Ile Val Gly Gly Glu Ala Ser Thr Leu Thr Ile Trp Asp 
545                 550                 555                 560 


Leu Ala Ser Pro Thr Pro Arg Ile Lys Ala Glu Leu Thr Ser Ser Ala 
                565                 570                 575     


Pro Ala Cys Tyr Ala Leu Ala Ile Ser Pro Asp Ala Lys Val Cys Phe 
            580                 585                 590         


Ser Cys Cys Ser Asp Gly Asn Ile Ala Val Trp Asp Leu His Asn Gln 
        595                 600                 605             


Thr Leu Val Arg Gln Phe Gln Gly His Thr Asp Gly Ala Ser Cys Ile 
    610                 615                 620                 


Asp Ile Ser His Asp Gly Thr Lys Leu Trp Thr Gly Gly Leu Asp Asn 
625                 630                 635                 640 


Thr Val Arg Ser Trp Asp Leu Arg Glu Gly Arg Gln Leu Gln Gln His 
                645                 650                 655     


Asp Phe Thr Ser Gln Ile Phe Ser Leu Gly Tyr Cys Pro Thr Gly Glu 
            660                 665                 670         


Trp Leu Ala Val Gly Met Glu Ser Ser Asn Val Glu Val Leu His His 
        675                 680                 685             


Thr Lys Pro Asp Lys Tyr Gln Leu His Leu His Glu Ser Cys Val Leu 
    690                 695                 700                 


Ser Leu Lys Phe Ala Tyr Cys Gly Lys Trp Phe Val Ser Thr Gly Lys 
705                 710                 715                 720 


Asp Asn Leu Leu Asn Ala Trp Arg Thr Pro Tyr Gly Ala Ser Ile Phe 
                725                 730                 735     


Gln Ser Lys Glu Ser Ser Ser Val Leu Ser Cys Asp Ile Ser Ala Asp 
            740                 745                 750         


Asp Lys Tyr Ile Val Thr Gly Ser Gly Asp Lys Lys Ala Thr Val Tyr 
        755                 760                 765             


Glu Val Ile Tyr 
    770         


<210> 18
<211> 760
<212> PRT
<213> Homo sapiens

<400> 18
Met Tyr Pro Gln Gly Arg His Pro Ala Pro His Gln Pro Gly Gln Pro 
1               5                   10                  15      


Gly Phe Lys Phe Thr Val Ala Glu Ser Cys Asp Arg Ile Lys Asp Glu 
            20                  25                  30          


Phe Gln Phe Leu Gln Ala Gln Tyr His Ser Leu Lys Val Glu Tyr Asp 
        35                  40                  45              


Lys Leu Ala Asn Glu Lys Thr Glu Met Gln Arg His Tyr Val Met Tyr 
    50                  55                  60                  


Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Thr Glu 
65                  70                  75                  80  


Ile Ala Lys Arg Leu Asn Thr Ile Leu Ala Gln Ile Met Pro Phe Leu 
                85                  90                  95      


Ser Gln Glu His Gln Gln Gln Val Ala Gln Ala Val Glu Arg Ala Lys 
            100                 105                 110         


Gln Val Thr Met Thr Glu Leu Asn Ala Ile Ile Gly Gln Gln Gln Leu 
        115                 120                 125             


Gln Ala Gln His Leu Ser His Ala Thr His Gly Pro Pro Val Gln Leu 
    130                 135                 140                 


Pro Pro His Pro Ser Gly Leu Gln Pro Pro Gly Ile Pro Pro Val Thr 
145                 150                 155                 160 


Gly Ser Ser Ser Gly Leu Leu Ala Leu Gly Ala Leu Gly Ser Gln Ala 
                165                 170                 175     


His Leu Thr Val Lys Asp Glu Lys Asn His His Glu Leu Asp His Arg 
            180                 185                 190         


Glu Arg Glu Ser Ser Ala Asn Asn Ser Val Ser Pro Ser Glu Ser Leu 
        195                 200                 205             


Arg Ala Ser Glu Lys His Arg Gly Ser Ala Asp Tyr Ser Met Glu Ala 
    210                 215                 220                 


Lys Lys Arg Lys Ala Glu Glu Lys Asp Ser Leu Ser Arg Tyr Asp Ser 
225                 230                 235                 240 


Asp Gly Asp Lys Ser Asp Asp Leu Val Val Asp Val Ser Asn Glu Asp 
                245                 250                 255     


Pro Ala Thr Pro Arg Val Ser Pro Ala His Ser Pro Pro Glu Asn Gly 
            260                 265                 270         


Leu Asp Lys Ala Arg Ser Leu Lys Lys Asp Ala Pro Thr Ser Pro Ala 
        275                 280                 285             


Ser Val Ala Ser Ser Ser Ser Thr Pro Ser Ser Lys Thr Lys Asp Leu 
    290                 295                 300                 


Gly His Asn Asp Lys Ser Ser Thr Pro Gly Leu Lys Ser Asn Thr Pro 
305                 310                 315                 320 


Thr Pro Arg Asn Asp Ala Pro Thr Pro Gly Thr Ser Thr Thr Pro Gly 
                325                 330                 335     


Leu Arg Ser Met Pro Ala Ser Ala Leu Arg Thr Pro Ile Ser Ile Thr 
            340                 345                 350         


Ser Ser Tyr Ala Ala Pro Phe Ala Met Met Ser His His Glu Met Asn 
        355                 360                 365             


Gly Ser Leu Thr Ser Pro Gly Ala Tyr Ala Gly Leu His Asn Ile Pro 
    370                 375                 380                 


Pro Gln Met Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Tyr Gly Arg 
385                 390                 395                 400 


Ser Pro Met Val Ser Phe Gly Ala Val Gly Phe Asp Pro His Pro Pro 
                405                 410                 415     


Met Arg Ala Thr Gly Leu Pro Ser Ser Leu Ala Ser Ile Pro Gly Gly 
            420                 425                 430         


Lys Pro Ala Tyr Ser Phe His Val Ser Ala Asp Gly Gln Met Gln Pro 
        435                 440                 445             


Val Pro Phe Pro His Asp Ala Leu Ala Gly Pro Gly Ile Pro Arg His 
    450                 455                 460                 


Ala Arg Gln Ile Asn Thr Leu Ser His Gly Glu Val Val Cys Ala Val 
465                 470                 475                 480 


Thr Ile Ser Asn Pro Thr Arg His Val Tyr Thr Gly Gly Lys Gly Cys 
                485                 490                 495     


Val Lys Ile Trp Asp Ile Ser Gln Pro Gly Ser Lys Ser Pro Ile Ser 
            500                 505                 510         


Gln Leu Asp Cys Leu Asn Arg Asp Asn Tyr Ile Arg Ser Cys Lys Leu 
        515                 520                 525             


Leu Pro Asp Gly Arg Thr Leu Ile Val Gly Gly Glu Ala Ser Thr Leu 
    530                 535                 540                 


Thr Ile Trp Asp Leu Ala Ser Pro Thr Pro Arg Ile Lys Ala Glu Leu 
545                 550                 555                 560 


Thr Ser Ser Ala Pro Ala Cys Tyr Ala Leu Ala Ile Ser Pro Asp Ala 
                565                 570                 575     


Lys Val Cys Phe Ser Cys Cys Ser Asp Gly Asn Ile Ala Val Trp Asp 
            580                 585                 590         


Leu His Asn Gln Thr Leu Val Arg Gln Phe Gln Gly His Thr Asp Gly 
        595                 600                 605             


Ala Ser Cys Ile Asp Ile Ser His Asp Gly Thr Lys Leu Trp Thr Gly 
    610                 615                 620                 


Gly Leu Asp Asn Thr Val Arg Ser Trp Asp Leu Arg Glu Gly Arg Gln 
625                 630                 635                 640 


Leu Gln Gln His Asp Phe Thr Ser Gln Ile Phe Ser Leu Gly Tyr Cys 
                645                 650                 655     


Pro Thr Gly Glu Trp Leu Ala Val Gly Met Glu Ser Ser Asn Val Glu 
            660                 665                 670         


Val Leu His His Thr Lys Pro Asp Lys Tyr Gln Leu His Leu His Glu 
        675                 680                 685             


Ser Cys Val Leu Ser Leu Lys Phe Ala Tyr Cys Gly Lys Trp Phe Val 
    690                 695                 700                 


Ser Thr Gly Lys Asp Asn Leu Leu Asn Ala Trp Arg Thr Pro Tyr Gly 
705                 710                 715                 720 


Ala Ser Ile Phe Gln Ser Lys Glu Ser Ser Ser Val Leu Ser Cys Asp 
                725                 730                 735     


Ile Ser Ala Asp Asp Lys Tyr Ile Val Thr Gly Ser Gly Asp Lys Lys 
            740                 745                 750         


Ala Thr Val Tyr Glu Val Ile Tyr 
        755                 760 


<210> 19
<211> 764
<212> PRT
<213> Homo sapiens

<400> 19
Met Tyr Pro Gln Gly Arg His Pro Ala Pro His Gln Pro Gly Gln Pro 
1               5                   10                  15      


Gly Phe Lys Phe Thr Val Ala Glu Ser Cys Asp Arg Ile Lys Asp Glu 
            20                  25                  30          


Phe Gln Phe Leu Gln Ala Gln Tyr His Ser Leu Lys Val Glu Tyr Asp 
        35                  40                  45              


Lys Leu Ala Asn Glu Lys Thr Glu Met Gln Arg His Tyr Val Met Tyr 
    50                  55                  60                  


Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Thr Glu 
65                  70                  75                  80  


Ile Ala Lys Arg Leu Asn Thr Ile Leu Ala Gln Ile Met Pro Phe Leu 
                85                  90                  95      


Ser Gln Glu His Gln Gln Gln Val Ala Gln Ala Val Glu Arg Ala Lys 
            100                 105                 110         


Gln Val Thr Met Thr Glu Leu Asn Ala Ile Ile Gly Gln Gln Gln Leu 
        115                 120                 125             


Gln Ala Gln His Leu Ser His Ala Thr His Gly Pro Pro Val Gln Leu 
    130                 135                 140                 


Pro Pro His Pro Ser Gly Leu Gln Pro Pro Gly Ile Pro Pro Val Thr 
145                 150                 155                 160 


Gly Ser Ser Ser Gly Leu Leu Ala Leu Gly Ala Leu Gly Ser Gln Ala 
                165                 170                 175     


His Leu Thr Val Lys Asp Glu Lys Asn His His Glu Leu Asp His Arg 
            180                 185                 190         


Glu Arg Glu Ser Ser Ala Asn Asn Ser Val Ser Pro Ser Glu Ser Leu 
        195                 200                 205             


Arg Ala Ser Glu Lys His Arg Gly Ser Ala Asp Tyr Ser Met Glu Ala 
    210                 215                 220                 


Lys Lys Arg Lys Ala Glu Glu Lys Asp Ser Leu Ser Arg Tyr Asp Ser 
225                 230                 235                 240 


Asp Gly Asp Lys Ser Asp Asp Leu Val Val Asp Val Ser Asn Glu Asp 
                245                 250                 255     


Pro Ala Thr Pro Arg Val Ser Pro Ala His Ser Pro Pro Glu Asn Gly 
            260                 265                 270         


Leu Asp Lys Ala Arg Ser Leu Lys Lys Asp Ala Pro Thr Ser Pro Ala 
        275                 280                 285             


Ser Val Ala Ser Ser Ser Ser Thr Pro Ser Ser Lys Thr Lys Asp Leu 
    290                 295                 300                 


Gly His Asn Asp Lys Ser Ser Thr Pro Gly Leu Lys Ser Asn Thr Pro 
305                 310                 315                 320 


Thr Pro Arg Asn Asp Ala Pro Thr Pro Gly Thr Ser Thr Thr Pro Gly 
                325                 330                 335     


Leu Arg Ser Met Pro Gly Lys Pro Pro Gly Met Asp Pro Ile Ala Ser 
            340                 345                 350         


Ala Leu Arg Thr Pro Ile Ser Ile Thr Ser Ser Tyr Ala Ala Pro Phe 
        355                 360                 365             


Ala Met Met Ser His His Glu Met Asn Gly Ser Leu Thr Ser Pro Gly 
    370                 375                 380                 


Ala Tyr Ala Gly Leu His Asn Ile Pro Pro Gln Met Ser Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Tyr Gly Arg Ser Pro Met Val Gly Phe Asp 
                405                 410                 415     


Pro His Pro Pro Met Arg Ala Thr Gly Leu Pro Ser Ser Leu Ala Ser 
            420                 425                 430         


Ile Pro Gly Gly Lys Pro Ala Tyr Ser Phe His Val Ser Ala Asp Gly 
        435                 440                 445             


Gln Met Gln Pro Val Pro Phe Pro His Asp Ala Leu Ala Gly Pro Gly 
    450                 455                 460                 


Ile Pro Arg His Ala Arg Gln Ile Asn Thr Leu Ser His Gly Glu Val 
465                 470                 475                 480 


Val Cys Ala Val Thr Ile Ser Asn Pro Thr Arg His Val Tyr Thr Gly 
                485                 490                 495     


Gly Lys Gly Cys Val Lys Ile Trp Asp Ile Ser Gln Pro Gly Ser Lys 
            500                 505                 510         


Ser Pro Ile Ser Gln Leu Asp Cys Leu Asn Arg Asp Asn Tyr Ile Arg 
        515                 520                 525             


Ser Cys Lys Leu Leu Pro Asp Gly Arg Thr Leu Ile Val Gly Gly Glu 
    530                 535                 540                 


Ala Ser Thr Leu Thr Ile Trp Asp Leu Ala Ser Pro Thr Pro Arg Ile 
545                 550                 555                 560 


Lys Ala Glu Leu Thr Ser Ser Ala Pro Ala Cys Tyr Ala Leu Ala Ile 
                565                 570                 575     


Ser Pro Asp Ala Lys Val Cys Phe Ser Cys Cys Ser Asp Gly Asn Ile 
            580                 585                 590         


Ala Val Trp Asp Leu His Asn Gln Thr Leu Val Arg Gln Phe Gln Gly 
        595                 600                 605             


His Thr Asp Gly Ala Ser Cys Ile Asp Ile Ser His Asp Gly Thr Lys 
    610                 615                 620                 


Leu Trp Thr Gly Gly Leu Asp Asn Thr Val Arg Ser Trp Asp Leu Arg 
625                 630                 635                 640 


Glu Gly Arg Gln Leu Gln Gln His Asp Phe Thr Ser Gln Ile Phe Ser 
                645                 650                 655     


Leu Gly Tyr Cys Pro Thr Gly Glu Trp Leu Ala Val Gly Met Glu Ser 
            660                 665                 670         


Ser Asn Val Glu Val Leu His His Thr Lys Pro Asp Lys Tyr Gln Leu 
        675                 680                 685             


His Leu His Glu Ser Cys Val Leu Ser Leu Lys Phe Ala Tyr Cys Gly 
    690                 695                 700                 


Lys Trp Phe Val Ser Thr Gly Lys Asp Asn Leu Leu Asn Ala Trp Arg 
705                 710                 715                 720 


Thr Pro Tyr Gly Ala Ser Ile Phe Gln Ser Lys Glu Ser Ser Ser Val 
                725                 730                 735     


Leu Ser Cys Asp Ile Ser Ala Asp Asp Lys Tyr Ile Val Thr Gly Ser 
            740                 745                 750         


Gly Asp Lys Lys Ala Thr Val Tyr Glu Val Ile Tyr 
        755                 760                 


<210> 20
<211> 772
<212> PRT
<213> Homo sapiens

<400> 20
Met Pro Pro Pro Pro Pro Leu Ser Cys Leu Arg Gly Leu Gln Ala Pro 
1               5                   10                  15      


His Gln Pro Gly Gln Pro Gly Phe Lys Phe Thr Val Ala Glu Ser Cys 
            20                  25                  30          


Asp Arg Ile Lys Asp Glu Phe Gln Phe Leu Gln Ala Gln Tyr His Ser 
        35                  40                  45              


Leu Lys Val Glu Tyr Asp Lys Leu Ala Asn Glu Lys Thr Glu Met Gln 
    50                  55                  60                  


Arg His Tyr Val Met Tyr Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu 
65                  70                  75                  80  


Met His Lys Gln Thr Glu Ile Ala Lys Arg Leu Asn Thr Ile Leu Ala 
                85                  90                  95      


Gln Ile Met Pro Phe Leu Ser Gln Glu His Gln Gln Gln Val Ala Gln 
            100                 105                 110         


Ala Val Glu Arg Ala Lys Gln Val Thr Met Thr Glu Leu Asn Ala Ile 
        115                 120                 125             


Ile Gly Gln Gln Leu Gln Ala Gln His Leu Ser His Ala Thr His Gly 
    130                 135                 140                 


Pro Pro Val Gln Leu Pro Pro His Pro Ser Gly Leu Gln Pro Pro Gly 
145                 150                 155                 160 


Ile Pro Pro Val Thr Gly Ser Ser Ser Gly Leu Leu Ala Leu Gly Ala 
                165                 170                 175     


Leu Gly Ser Gln Ala His Leu Thr Val Lys Asp Glu Lys Asn His His 
            180                 185                 190         


Glu Leu Asp His Arg Glu Arg Glu Ser Ser Ala Asn Asn Ser Val Ser 
        195                 200                 205             


Pro Ser Glu Ser Leu Arg Ala Ser Glu Lys His Arg Gly Ser Ala Asp 
    210                 215                 220                 


Tyr Ser Met Glu Ala Lys Lys Arg Lys Ala Glu Glu Lys Asp Ser Leu 
225                 230                 235                 240 


Ser Arg Tyr Asp Ser Asp Gly Asp Lys Ser Asp Asp Leu Val Val Asp 
                245                 250                 255     


Val Ser Asn Glu Asp Pro Ala Thr Pro Arg Val Ser Pro Ala His Ser 
            260                 265                 270         


Pro Pro Glu Asn Gly Leu Asp Lys Ala Arg Ser Leu Lys Lys Asp Ala 
        275                 280                 285             


Pro Thr Ser Pro Ala Ser Val Ala Ser Ser Ser Ser Thr Pro Ser Ser 
    290                 295                 300                 


Lys Thr Lys Asp Leu Gly His Asn Asp Lys Ser Ser Thr Pro Gly Leu 
305                 310                 315                 320 


Lys Ser Asn Thr Pro Thr Pro Arg Asn Asp Ala Pro Thr Pro Gly Thr 
                325                 330                 335     


Ser Thr Thr Pro Gly Leu Arg Ser Met Pro Gly Lys Pro Pro Gly Met 
            340                 345                 350         


Asp Pro Ile Gly Ile Met Ala Ser Ala Leu Arg Thr Pro Ile Ser Ile 
        355                 360                 365             


Thr Ser Ser Tyr Ala Ala Pro Phe Ala Met Met Ser His His Glu Met 
    370                 375                 380                 


Asn Gly Ser Leu Thr Ser Pro Gly Ala Tyr Ala Gly Leu His Asn Ile 
385                 390                 395                 400 


Pro Pro Gln Met Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Tyr Gly 
                405                 410                 415     


Arg Ser Pro Met Val Gly Phe Asp Pro His Pro Pro Met Arg Ala Thr 
            420                 425                 430         


Gly Leu Pro Ser Ser Leu Ala Ser Ile Pro Gly Gly Lys Pro Ala Tyr 
        435                 440                 445             


Ser Phe His Val Ser Ala Asp Gly Gln Met Gln Pro Val Pro Phe Pro 
    450                 455                 460                 


His Asp Ala Leu Ala Gly Pro Gly Ile Pro Arg His Ala Arg Gln Ile 
465                 470                 475                 480 


Asn Thr Leu Ser His Gly Glu Val Val Cys Ala Val Thr Ile Ser Asn 
                485                 490                 495     


Pro Thr Arg His Val Tyr Thr Gly Gly Lys Gly Cys Val Lys Ile Trp 
            500                 505                 510         


Asp Ile Ser Gln Pro Gly Ser Lys Ser Pro Ile Ser Gln Leu Asp Cys 
        515                 520                 525             


Leu Asn Arg Asp Asn Tyr Ile Arg Ser Cys Lys Leu Leu Pro Asp Gly 
    530                 535                 540                 


Arg Thr Leu Ile Val Gly Gly Glu Ala Ser Thr Leu Thr Ile Trp Asp 
545                 550                 555                 560 


Leu Ala Ser Pro Thr Pro Arg Ile Lys Ala Glu Leu Thr Ser Ser Ala 
                565                 570                 575     


Pro Ala Cys Tyr Ala Leu Ala Ile Ser Pro Asp Ala Lys Val Cys Phe 
            580                 585                 590         


Ser Cys Cys Ser Asp Gly Asn Ile Ala Val Trp Asp Leu His Asn Gln 
        595                 600                 605             


Thr Leu Val Arg Gln Phe Gln Gly His Thr Asp Gly Ala Ser Cys Ile 
    610                 615                 620                 


Asp Ile Ser His Asp Gly Thr Lys Leu Trp Thr Gly Gly Leu Asp Asn 
625                 630                 635                 640 


Thr Val Arg Ser Trp Asp Leu Arg Glu Gly Arg Gln Leu Gln Gln His 
                645                 650                 655     


Asp Phe Thr Ser Gln Ile Phe Ser Leu Gly Tyr Cys Pro Thr Gly Glu 
            660                 665                 670         


Trp Leu Ala Val Gly Met Glu Ser Ser Asn Val Glu Val Leu His His 
        675                 680                 685             


Thr Lys Pro Asp Lys Tyr Gln Leu His Leu His Glu Ser Cys Val Leu 
    690                 695                 700                 


Ser Leu Lys Phe Ala Tyr Cys Gly Lys Trp Phe Val Ser Thr Gly Lys 
705                 710                 715                 720 


Asp Asn Leu Leu Asn Ala Trp Arg Thr Pro Tyr Gly Ala Ser Ile Phe 
                725                 730                 735     


Gln Ser Lys Glu Ser Ser Ser Val Leu Ser Cys Asp Ile Ser Ala Asp 
            740                 745                 750         


Asp Lys Tyr Ile Val Thr Gly Ser Gly Asp Lys Lys Ala Thr Val Tyr 
        755                 760                 765             


Glu Val Ile Tyr 
    770         


<210> 21
<211> 769
<212> PRT
<213> Homo sapiens

<400> 21
Met Tyr Pro Gln Gly Arg His Pro Ala Pro His Gln Pro Gly Gln Pro 
1               5                   10                  15      


Gly Phe Lys Phe Thr Val Ala Glu Ser Cys Asp Arg Ile Lys Asp Glu 
            20                  25                  30          


Phe Gln Phe Leu Gln Ala Gln Tyr His Ser Leu Lys Val Glu Tyr Asp 
        35                  40                  45              


Lys Leu Ala Asn Glu Lys Thr Glu Met Gln Arg His Tyr Val Met Tyr 
    50                  55                  60                  


Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Thr Glu 
65                  70                  75                  80  


Ile Ala Lys Arg Leu Asn Thr Ile Leu Ala Gln Ile Met Pro Phe Leu 
                85                  90                  95      


Ser Gln Glu His Gln Gln Gln Val Ala Gln Ala Val Glu Arg Ala Lys 
            100                 105                 110         


Gln Val Thr Met Thr Glu Leu Asn Ala Ile Ile Gly Gln Gln Gln Leu 
        115                 120                 125             


Gln Ala Gln His Leu Ser His Ala Thr His Gly Pro Pro Val Gln Leu 
    130                 135                 140                 


Pro Pro His Pro Ser Gly Leu Gln Pro Pro Gly Ile Pro Pro Val Thr 
145                 150                 155                 160 


Gly Ser Ser Ser Gly Leu Leu Ala Leu Gly Ala Leu Gly Ser Gln Ala 
                165                 170                 175     


His Leu Thr Val Lys Asp Glu Lys Asn His His Glu Leu Asp His Arg 
            180                 185                 190         


Glu Arg Glu Ser Ser Ala Asn Asn Ser Val Ser Pro Ser Glu Ser Leu 
        195                 200                 205             


Arg Ala Ser Glu Lys His Arg Gly Ser Ala Asp Tyr Ser Met Glu Ala 
    210                 215                 220                 


Lys Lys Arg Lys Ala Glu Glu Lys Asp Ser Leu Ser Arg Tyr Asp Ser 
225                 230                 235                 240 


Asp Gly Asp Lys Ser Asp Asp Leu Val Val Asp Val Ser Asn Glu Asp 
                245                 250                 255     


Pro Ala Thr Pro Arg Val Ser Pro Ala His Ser Pro Pro Glu Asn Gly 
            260                 265                 270         


Leu Asp Lys Ala Arg Ser Leu Lys Lys Asp Ala Pro Thr Ser Pro Ala 
        275                 280                 285             


Ser Val Ala Ser Ser Ser Ser Thr Pro Ser Ser Lys Thr Lys Asp Leu 
    290                 295                 300                 


Gly His Asn Asp Lys Ser Ser Thr Pro Gly Leu Lys Ser Asn Thr Pro 
305                 310                 315                 320 


Thr Pro Arg Asn Asp Ala Pro Thr Pro Gly Thr Ser Thr Thr Pro Gly 
                325                 330                 335     


Leu Arg Ser Met Pro Gly Lys Pro Pro Gly Met Asp Pro Ile Ala Ser 
            340                 345                 350         


Ala Leu Arg Thr Pro Ile Ser Ile Thr Ser Ser Tyr Ala Ala Pro Phe 
        355                 360                 365             


Ala Met Met Ser His His Glu Met Asn Gly Ser Leu Thr Ser Pro Gly 
    370                 375                 380                 


Ala Tyr Ala Gly Leu His Asn Ile Pro Pro Gln Met Ser Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Tyr Gly Arg Ser Pro Met Val Ser Phe Gly 
                405                 410                 415     


Ala Val Gly Phe Asp Pro His Pro Pro Met Arg Ala Thr Gly Leu Pro 
            420                 425                 430         


Ser Ser Leu Ala Ser Ile Pro Gly Gly Lys Pro Ala Tyr Ser Phe His 
        435                 440                 445             


Val Ser Ala Asp Gly Gln Met Gln Pro Val Pro Phe Pro His Asp Ala 
    450                 455                 460                 


Leu Ala Gly Pro Gly Ile Pro Arg His Ala Arg Gln Ile Asn Thr Leu 
465                 470                 475                 480 


Ser His Gly Glu Val Val Cys Ala Val Thr Ile Ser Asn Pro Thr Arg 
                485                 490                 495     


His Val Tyr Thr Gly Gly Lys Gly Cys Val Lys Ile Trp Asp Ile Ser 
            500                 505                 510         


Gln Pro Gly Ser Lys Ser Pro Ile Ser Gln Leu Asp Cys Leu Asn Arg 
        515                 520                 525             


Asp Asn Tyr Ile Arg Ser Cys Lys Leu Leu Pro Asp Gly Arg Thr Leu 
    530                 535                 540                 


Ile Val Gly Gly Glu Ala Ser Thr Leu Thr Ile Trp Asp Leu Ala Ser 
545                 550                 555                 560 


Pro Thr Pro Arg Ile Lys Ala Glu Leu Thr Ser Ser Ala Pro Ala Cys 
                565                 570                 575     


Tyr Ala Leu Ala Ile Ser Pro Asp Ala Lys Val Cys Phe Ser Cys Cys 
            580                 585                 590         


Ser Asp Gly Asn Ile Ala Val Trp Asp Leu His Asn Gln Thr Leu Val 
        595                 600                 605             


Arg Gln Phe Gln Gly His Thr Asp Gly Ala Ser Cys Ile Asp Ile Ser 
    610                 615                 620                 


His Asp Gly Thr Lys Leu Trp Thr Gly Gly Leu Asp Asn Thr Val Arg 
625                 630                 635                 640 


Ser Trp Asp Leu Arg Glu Gly Arg Gln Leu Gln Gln His Asp Phe Thr 
                645                 650                 655     


Ser Gln Ile Phe Ser Leu Gly Tyr Cys Pro Thr Gly Glu Trp Leu Ala 
            660                 665                 670         


Val Gly Met Glu Ser Ser Asn Val Glu Val Leu His His Thr Lys Pro 
        675                 680                 685             


Asp Lys Tyr Gln Leu His Leu His Glu Ser Cys Val Leu Ser Leu Lys 
    690                 695                 700                 


Phe Ala Tyr Cys Gly Lys Trp Phe Val Ser Thr Gly Lys Asp Asn Leu 
705                 710                 715                 720 


Leu Asn Ala Trp Arg Thr Pro Tyr Gly Ala Ser Ile Phe Gln Ser Lys 
                725                 730                 735     


Glu Ser Ser Ser Val Leu Ser Cys Asp Ile Ser Ala Asp Asp Lys Tyr 
            740                 745                 750         


Ile Val Thr Gly Ser Gly Asp Lys Lys Ala Thr Val Tyr Glu Val Ile 
        755                 760                 765             


Tyr 
    


<210> 22
<211> 767
<212> PRT
<213> Homo sapiens

<400> 22
Met Tyr Pro Gln Gly Arg His Pro Ala Pro His Gln Pro Gly Gln Pro 
1               5                   10                  15      


Gly Phe Lys Phe Thr Val Ala Glu Ser Cys Asp Arg Ile Lys Asp Glu 
            20                  25                  30          


Phe Gln Phe Leu Gln Ala Gln Tyr His Ser Leu Lys Val Glu Tyr Asp 
        35                  40                  45              


Lys Leu Ala Asn Glu Lys Thr Glu Met Gln Arg His Tyr Val Met Tyr 
    50                  55                  60                  


Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Thr Glu 
65                  70                  75                  80  


Ile Ala Lys Arg Leu Asn Thr Ile Leu Ala Gln Ile Met Pro Phe Leu 
                85                  90                  95      


Ser Gln Glu His Gln Gln Gln Val Ala Gln Ala Val Glu Arg Ala Lys 
            100                 105                 110         


Gln Val Thr Met Thr Glu Leu Asn Ala Ile Ile Gly Gln Gln Gln Leu 
        115                 120                 125             


Gln Ala Gln His Leu Ser His Ala Thr His Gly Pro Pro Val Gln Leu 
    130                 135                 140                 


Pro Pro His Pro Ser Gly Leu Gln Pro Pro Gly Ile Pro Pro Val Thr 
145                 150                 155                 160 


Gly Ser Ser Ser Gly Leu Leu Ala Leu Gly Ala Leu Gly Ser Gln Ala 
                165                 170                 175     


His Leu Thr Val Lys Asp Glu Lys Asn His His Glu Leu Asp His Arg 
            180                 185                 190         


Glu Arg Glu Ser Ser Ala Asn Asn Ser Val Ser Pro Ser Glu Ser Leu 
        195                 200                 205             


Arg Ala Ser Glu Lys His Arg Gly Ser Ala Asp Tyr Ser Met Glu Ala 
    210                 215                 220                 


Lys Lys Arg Lys Ala Glu Glu Lys Asp Ser Leu Ser Arg Tyr Asp Ser 
225                 230                 235                 240 


Asp Gly Asp Lys Ser Asp Asp Leu Val Val Asp Val Ser Asn Glu Asp 
                245                 250                 255     


Pro Ala Thr Pro Arg Val Ser Pro Ala His Ser Pro Pro Glu Asn Gly 
            260                 265                 270         


Leu Asp Lys Ala Arg Ser Leu Lys Lys Asp Ala Pro Thr Ser Pro Ala 
        275                 280                 285             


Ser Val Ala Ser Ser Ser Ser Thr Pro Ser Ser Lys Thr Lys Asp Leu 
    290                 295                 300                 


Gly His Asn Asp Lys Ser Ser Thr Pro Gly Leu Lys Ser Asn Thr Pro 
305                 310                 315                 320 


Thr Pro Arg Asn Asp Ala Pro Thr Pro Gly Thr Ser Thr Thr Pro Gly 
                325                 330                 335     


Leu Arg Ser Met Pro Gly Lys Pro Pro Gly Met Asp Pro Ile Gly Ile 
            340                 345                 350         


Met Ala Ser Ala Leu Arg Thr Pro Ile Ser Ile Thr Ser Ser Tyr Ala 
        355                 360                 365             


Ala Pro Phe Ala Met Met Ser His His Glu Met Asn Gly Ser Leu Thr 
    370                 375                 380                 


Ser Pro Gly Ala Tyr Ala Gly Leu His Asn Ile Pro Pro Gln Met Ser 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Tyr Gly Arg Ser Pro Met Val 
                405                 410                 415     


Gly Phe Asp Pro His Pro Pro Met Arg Ala Thr Gly Leu Pro Ser Ser 
            420                 425                 430         


Leu Ala Ser Ile Pro Gly Gly Lys Pro Ala Tyr Ser Phe His Val Ser 
        435                 440                 445             


Ala Asp Gly Gln Met Gln Pro Val Pro Phe Pro His Asp Ala Leu Ala 
    450                 455                 460                 


Gly Pro Gly Ile Pro Arg His Ala Arg Gln Ile Asn Thr Leu Ser His 
465                 470                 475                 480 


Gly Glu Val Val Cys Ala Val Thr Ile Ser Asn Pro Thr Arg His Val 
                485                 490                 495     


Tyr Thr Gly Gly Lys Gly Cys Val Lys Ile Trp Asp Ile Ser Gln Pro 
            500                 505                 510         


Gly Ser Lys Ser Pro Ile Ser Gln Leu Asp Cys Leu Asn Arg Asp Asn 
        515                 520                 525             


Tyr Ile Arg Ser Cys Lys Leu Leu Pro Asp Gly Arg Thr Leu Ile Val 
    530                 535                 540                 


Gly Gly Glu Ala Ser Thr Leu Thr Ile Trp Asp Leu Ala Ser Pro Thr 
545                 550                 555                 560 


Pro Arg Ile Lys Ala Glu Leu Thr Ser Ser Ala Pro Ala Cys Tyr Ala 
                565                 570                 575     


Leu Ala Ile Ser Pro Asp Ala Lys Val Cys Phe Ser Cys Cys Ser Asp 
            580                 585                 590         


Gly Asn Ile Ala Val Trp Asp Leu His Asn Gln Thr Leu Val Arg Gln 
        595                 600                 605             


Phe Gln Gly His Thr Asp Gly Ala Ser Cys Ile Asp Ile Ser His Asp 
    610                 615                 620                 


Gly Thr Lys Leu Trp Thr Gly Gly Leu Asp Asn Thr Val Arg Ser Trp 
625                 630                 635                 640 


Asp Leu Arg Glu Gly Arg Gln Leu Gln Gln His Asp Phe Thr Ser Gln 
                645                 650                 655     


Ile Phe Ser Leu Gly Tyr Cys Pro Thr Gly Glu Trp Leu Ala Val Gly 
            660                 665                 670         


Met Glu Ser Ser Asn Val Glu Val Leu His His Thr Lys Pro Asp Lys 
        675                 680                 685             


Tyr Gln Leu His Leu His Glu Ser Cys Val Leu Ser Leu Lys Phe Ala 
    690                 695                 700                 


Tyr Cys Gly Lys Trp Phe Val Ser Thr Gly Lys Asp Asn Leu Leu Asn 
705                 710                 715                 720 


Ala Trp Arg Thr Pro Tyr Gly Ala Ser Ile Phe Gln Ser Lys Glu Ser 
                725                 730                 735     


Ser Ser Val Leu Ser Cys Asp Ile Ser Ala Asp Asp Lys Tyr Ile Val 
            740                 745                 750         


Thr Gly Ser Gly Asp Lys Lys Ala Thr Val Tyr Glu Val Ile Tyr 
        755                 760                 765         


<210> 23
<211> 762
<212> PRT
<213> Homo sapiens

<400> 23
Met Ala Pro His Gln Pro Gly Gln Pro Gly Phe Lys Phe Thr Val Ala 
1               5                   10                  15      


Glu Ser Cys Asp Arg Ile Lys Asp Glu Phe Gln Phe Leu Gln Ala Gln 
            20                  25                  30          


Tyr His Ser Leu Lys Val Glu Tyr Asp Lys Leu Ala Asn Glu Lys Thr 
        35                  40                  45              


Glu Met Gln Arg His Tyr Val Met Tyr Tyr Glu Met Ser Tyr Gly Leu 
    50                  55                  60                  


Asn Ile Glu Met His Lys Gln Thr Glu Ile Ala Lys Arg Leu Asn Thr 
65                  70                  75                  80  


Ile Leu Ala Gln Ile Met Pro Phe Leu Ser Gln Glu His Gln Gln Gln 
                85                  90                  95      


Val Ala Gln Ala Val Glu Arg Ala Lys Gln Val Thr Met Thr Glu Leu 
            100                 105                 110         


Asn Ala Ile Ile Gly Gln Gln Gln Leu Gln Ala Gln His Leu Ser His 
        115                 120                 125             


Ala Thr His Gly Pro Pro Val Gln Leu Pro Pro His Pro Ser Gly Leu 
    130                 135                 140                 


Gln Pro Pro Gly Ile Pro Pro Val Thr Gly Ser Ser Ser Gly Leu Leu 
145                 150                 155                 160 


Ala Leu Gly Ala Leu Gly Ser Gln Ala His Leu Thr Val Lys Asp Glu 
                165                 170                 175     


Lys Asn His His Glu Leu Asp His Arg Glu Arg Glu Ser Ser Ala Asn 
            180                 185                 190         


Asn Ser Val Ser Pro Ser Glu Ser Leu Arg Ala Ser Glu Lys His Arg 
        195                 200                 205             


Gly Ser Ala Asp Tyr Ser Met Glu Ala Lys Lys Arg Lys Ala Glu Glu 
    210                 215                 220                 


Lys Asp Ser Leu Ser Arg Tyr Asp Ser Asp Gly Asp Lys Ser Asp Asp 
225                 230                 235                 240 


Leu Val Val Asp Val Ser Asn Glu Asp Pro Ala Thr Pro Arg Val Ser 
                245                 250                 255     


Pro Ala His Ser Pro Pro Glu Asn Gly Leu Asp Lys Ala Arg Ser Leu 
            260                 265                 270         


Lys Lys Asp Ala Pro Thr Ser Pro Ala Ser Val Ala Ser Ser Ser Ser 
        275                 280                 285             


Thr Pro Ser Ser Lys Thr Lys Asp Leu Gly His Asn Asp Lys Ser Ser 
    290                 295                 300                 


Thr Pro Gly Leu Lys Ser Asn Thr Pro Thr Pro Arg Asn Asp Ala Pro 
305                 310                 315                 320 


Thr Pro Gly Thr Ser Thr Thr Pro Gly Leu Arg Ser Met Pro Gly Lys 
                325                 330                 335     


Pro Pro Gly Met Asp Pro Ile Ala Ser Ala Leu Arg Thr Pro Ile Ser 
            340                 345                 350         


Ile Thr Ser Ser Tyr Ala Ala Pro Phe Ala Met Met Ser His His Glu 
        355                 360                 365             


Met Asn Gly Ser Leu Thr Ser Pro Gly Ala Tyr Ala Gly Leu His Asn 
    370                 375                 380                 


Ile Pro Pro Gln Met Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Tyr 
385                 390                 395                 400 


Gly Arg Ser Pro Met Val Ser Phe Gly Ala Val Gly Phe Asp Pro His 
                405                 410                 415     


Pro Pro Met Arg Ala Thr Gly Leu Pro Ser Ser Leu Ala Ser Ile Pro 
            420                 425                 430         


Gly Gly Lys Pro Ala Tyr Ser Phe His Val Ser Ala Asp Gly Gln Met 
        435                 440                 445             


Gln Pro Val Pro Phe Pro His Asp Ala Leu Ala Gly Pro Gly Ile Pro 
    450                 455                 460                 


Arg His Ala Arg Gln Ile Asn Thr Leu Ser His Gly Glu Val Val Cys 
465                 470                 475                 480 


Ala Val Thr Ile Ser Asn Pro Thr Arg His Val Tyr Thr Gly Gly Lys 
                485                 490                 495     


Gly Cys Val Lys Ile Trp Asp Ile Ser Gln Pro Gly Ser Lys Ser Pro 
            500                 505                 510         


Ile Ser Gln Leu Asp Cys Leu Asn Arg Asp Asn Tyr Ile Arg Ser Cys 
        515                 520                 525             


Lys Leu Leu Pro Asp Gly Arg Thr Leu Ile Val Gly Gly Glu Ala Ser 
    530                 535                 540                 


Thr Leu Thr Ile Trp Asp Leu Ala Ser Pro Thr Pro Arg Ile Lys Ala 
545                 550                 555                 560 


Glu Leu Thr Ser Ser Ala Pro Ala Cys Tyr Ala Leu Ala Ile Ser Pro 
                565                 570                 575     


Asp Ala Lys Val Cys Phe Ser Cys Cys Ser Asp Gly Asn Ile Ala Val 
            580                 585                 590         


Trp Asp Leu His Asn Gln Thr Leu Val Arg Gln Phe Gln Gly His Thr 
        595                 600                 605             


Asp Gly Ala Ser Cys Ile Asp Ile Ser His Asp Gly Thr Lys Leu Trp 
    610                 615                 620                 


Thr Gly Gly Leu Asp Asn Thr Val Arg Ser Trp Asp Leu Arg Glu Gly 
625                 630                 635                 640 


Arg Gln Leu Gln Gln His Asp Phe Thr Ser Gln Ile Phe Ser Leu Gly 
                645                 650                 655     


Tyr Cys Pro Thr Gly Glu Trp Leu Ala Val Gly Met Glu Ser Ser Asn 
            660                 665                 670         


Val Glu Val Leu His His Thr Lys Pro Asp Lys Tyr Gln Leu His Leu 
        675                 680                 685             


His Glu Ser Cys Val Leu Ser Leu Lys Phe Ala Tyr Cys Gly Lys Trp 
    690                 695                 700                 


Phe Val Ser Thr Gly Lys Asp Asn Leu Leu Asn Ala Trp Arg Thr Pro 
705                 710                 715                 720 


Tyr Gly Ala Ser Ile Phe Gln Ser Lys Glu Ser Ser Ser Val Leu Ser 
                725                 730                 735     


Cys Asp Ile Ser Ala Asp Asp Lys Tyr Ile Val Thr Gly Ser Gly Asp 
            740                 745                 750         


Lys Lys Ala Thr Val Tyr Glu Val Ile Tyr 
        755                 760         


<210> 24
<211> 802
<212> PRT
<213> Homo sapiens

<400> 24
Met Gly His Pro Pro Leu Glu Phe Ser Asp Cys Tyr Leu Asp Ser Pro 
1               5                   10                  15      


Asp Phe Arg Glu Arg Leu Lys Cys Tyr Glu Gln Glu Leu Glu Arg Thr 
            20                  25                  30          


Asn Lys Phe Ile Lys Asp Val Ile Lys Asp Gly Asn Ala Leu Ile Ser 
        35                  40                  45              


Ala Met Arg Asn Tyr Ser Ser Ala Val Gln Lys Phe Ser Gln Thr Leu 
    50                  55                  60                  


Gln Ser Phe Gln Phe Asp Phe Ile Gly Asp Thr Leu Thr Asp Asp Glu 
65                  70                  75                  80  


Ile Asn Ile Ala Glu Ser Phe Lys Glu Phe Ala Glu Leu Leu Asn Glu 
                85                  90                  95      


Val Glu Asn Glu Arg Met Met Met Val His Asn Ala Ser Asp Leu Leu 
            100                 105                 110         


Ile Lys Pro Leu Glu Asn Phe Arg Lys Glu Gln Ile Gly Phe Thr Lys 
        115                 120                 125             


Glu Arg Lys Lys Lys Phe Glu Lys Asp Gly Glu Arg Phe Tyr Ser Leu 
    130                 135                 140                 


Leu Asp Arg His Leu His Leu Ser Ser Lys Lys Lys Glu Ser Gln Leu 
145                 150                 155                 160 


Gln Glu Ala Asp Leu Gln Val Asp Lys Glu Arg His Asn Phe Phe Glu 
                165                 170                 175     


Ser Ser Leu Asp Tyr Val Tyr Gln Ile Gln Glu Val Gln Glu Ser Lys 
            180                 185                 190         


Lys Phe Asn Ile Val Glu Pro Val Leu Ala Phe Leu His Ser Leu Phe 
        195                 200                 205             


Ile Ser Asn Ser Leu Thr Val Glu Leu Thr Gln Asp Phe Leu Pro Tyr 
    210                 215                 220                 


Lys Gln Gln Leu Gln Leu Ser Leu Gln Asn Thr Arg Asn His Phe Ser 
225                 230                 235                 240 


Ser Thr Arg Glu Glu Met Glu Glu Leu Lys Lys Arg Met Lys Glu Ala 
                245                 250                 255     


Pro Gln Thr Cys Lys Leu Pro Gly Gln Pro Thr Ile Glu Gly Tyr Leu 
            260                 265                 270         


Tyr Thr Gln Glu Lys Trp Ala Leu Gly Ile Ser Trp Val Lys Tyr Tyr 
        275                 280                 285             


Cys Gln Tyr Glu Lys Glu Thr Lys Thr Leu Thr Met Thr Pro Met Glu 
    290                 295                 300                 


Gln Lys Pro Gly Ala Lys Gln Gly Pro Leu Asp Leu Thr Leu Lys Tyr 
305                 310                 315                 320 


Cys Val Arg Arg Lys Thr Glu Ser Ile Asp Lys Arg Phe Cys Phe Asp 
                325                 330                 335     


Ile Glu Thr Asn Glu Arg Pro Gly Thr Ile Thr Leu Gln Ala Leu Ser 
            340                 345                 350         


Glu Ala Asn Arg Arg Leu Trp Met Glu Ala Met Asp Gly Lys Glu Pro 
        355                 360                 365             


Ile Tyr His Ser Pro Ile Thr Lys Gln Gln Glu Met Glu Leu Asn Glu 
    370                 375                 380                 


Val Gly Phe Lys Phe Val Arg Lys Cys Ile Asn Ile Ile Glu Thr Lys 
385                 390                 395                 400 


Gly Ile Lys Thr Glu Gly Leu Tyr Arg Thr Val Gly Ser Asn Ile Gln 
                405                 410                 415     


Val Gln Lys Leu Leu Asn Ala Phe Phe Asp Pro Lys Cys Pro Gly Asp 
            420                 425                 430         


Val Asp Phe His Asn Ser Asp Trp Asp Ile Lys Thr Ile Thr Ser Ser 
        435                 440                 445             


Leu Lys Phe Tyr Leu Arg Asn Leu Ser Glu Pro Val Met Thr Tyr Arg 
    450                 455                 460                 


Leu His Lys Glu Leu Val Ser Ala Ala Lys Ser Asp Asn Leu Asp Tyr 
465                 470                 475                 480 


Arg Leu Gly Ala Ile His Ser Leu Val Tyr Lys Leu Pro Glu Lys Asn 
                485                 490                 495     


Arg Glu Met Leu Glu Leu Leu Ile Arg His Leu Val Asn Val Cys Glu 
            500                 505                 510         


His Ser Lys Glu Asn Leu Met Thr Pro Ser Asn Met Gly Val Ile Phe 
        515                 520                 525             


Gly Pro Thr Leu Met Arg Ala Gln Glu Asp Thr Val Ala Ala Met Met 
    530                 535                 540                 


Asn Ile Lys Phe Gln Asn Ile Val Val Glu Ile Leu Ile Glu His Phe 
545                 550                 555                 560 


Gly Lys Ile Tyr Leu Gly Pro Pro Glu Glu Ser Ala Ala Pro Pro Val 
                565                 570                 575     


Pro Pro Pro Arg Val Thr Ala Arg Arg His Lys Pro Ile Thr Ile Ser 
            580                 585                 590         


Lys Arg Leu Leu Arg Glu Arg Thr Val Phe Tyr Thr Ser Ser Leu Asp 
        595                 600                 605             


Glu Ser Glu Asp Glu Ile Gln His Gln Thr Pro Asn Gly Thr Ile Thr 
    610                 615                 620                 


Ser Ser Ile Glu Pro Pro Lys Pro Pro Gln His Pro Lys Leu Pro Ile 
625                 630                 635                 640 


Gln Arg Ser Gly Glu Thr Asp Pro Gly Arg Lys Ser Pro Ser Arg Pro 
                645                 650                 655     


Ile Leu Asp Gly Lys Leu Glu Pro Cys Pro Glu Val Asp Val Gly Lys 
            660                 665                 670         


Leu Val Ser Arg Leu Gln Asp Gly Gly Thr Lys Ile Thr Pro Lys Ala 
        675                 680                 685             


Thr Asn Gly Pro Met Pro Gly Ser Gly Pro Thr Lys Thr Pro Ser Phe 
    690                 695                 700                 


His Ile Lys Arg Pro Ala Pro Arg Pro Leu Ala His His Lys Glu Gly 
705                 710                 715                 720 


Asp Ala Asp Ser Phe Ser Lys Val Arg Pro Pro Gly Glu Lys Pro Thr 
                725                 730                 735     


Ile Ile Arg Pro Pro Val Arg Pro Pro Asp Pro Pro Cys Arg Ala Ala 
            740                 745                 750         


Thr Pro Gln Lys Pro Glu Pro Lys Pro Asp Ile Val Ala Gly Asn Ala 
        755                 760                 765             


Gly Glu Ile Thr Ser Ser Val Val Ala Ser Arg Thr Arg Phe Phe Glu 
    770                 775                 780                 


Thr Ala Ser Arg Lys Thr Gly Ser Ser Gln Gly Arg Leu Pro Gly Asp 
785                 790                 795                 800 


Glu Ser 
        


<210> 25
<211> 311
<212> PRT
<213> Homo sapiens

<400> 25
Met Gly His Pro Pro Leu Glu Phe Ser Asp Cys Tyr Leu Asp Ser Pro 
1               5                   10                  15      


Asp Phe Arg Glu Arg Leu Lys Cys Tyr Glu Gln Glu Leu Glu Arg Thr 
            20                  25                  30          


Asn Lys Phe Ile Lys Asp Val Ile Lys Asp Gly Asn Ala Leu Ile Ser 
        35                  40                  45              


Ala Met Arg Asn Tyr Ser Ser Ala Val Gln Lys Phe Ser Gln Thr Leu 
    50                  55                  60                  


Gln Ser Phe Gln Phe Asp Phe Ile Gly Asp Thr Leu Thr Asp Asp Glu 
65                  70                  75                  80  


Ile Asn Ile Ala Glu Ser Phe Lys Glu Phe Ala Glu Leu Leu Asn Glu 
                85                  90                  95      


Val Glu Asn Glu Arg Met Met Met Val His Asn Ala Ser Asp Leu Leu 
            100                 105                 110         


Ile Lys Pro Leu Glu Asn Phe Arg Lys Glu Gln Ile Gly Phe Thr Lys 
        115                 120                 125             


Glu Arg Lys Lys Lys Phe Glu Lys Asp Gly Glu Arg Phe Tyr Ser Leu 
    130                 135                 140                 


Leu Asp Arg His Leu His Leu Ser Ser Lys Lys Lys Glu Ser Gln Leu 
145                 150                 155                 160 


Gln Glu Ala Asp Leu Gln Val Asp Lys Glu Arg His Asn Phe Phe Glu 
                165                 170                 175     


Ser Ser Leu Asp Tyr Val Tyr Gln Ile Gln Glu Val Gln Glu Ser Lys 
            180                 185                 190         


Lys Phe Asn Ile Val Glu Pro Val Leu Ala Phe Leu His Ser Leu Phe 
        195                 200                 205             


Ile Ser Asn Ser Leu Thr Val Glu Leu Thr Gln Asp Phe Leu Pro Tyr 
    210                 215                 220                 


Lys Gln Gln Leu Gln Leu Ser Leu Gln Asn Thr Arg Asn His Phe Ser 
225                 230                 235                 240 


Ser Thr Arg Glu Glu Met Glu Glu Leu Lys Lys Arg Met Lys Glu Ala 
                245                 250                 255     


Pro Gln Thr Cys Lys Leu Pro Gly Gln Pro Thr Ile Glu Gly Tyr Leu 
            260                 265                 270         


Tyr Thr Gln Glu Lys Cys Val Trp Gly His Arg Gly Ile His Trp Val 
        275                 280                 285             


Ser Ile Ser Gln Glu Leu Leu Pro Leu Val Gly Cys Glu Phe Trp Ala 
    290                 295                 300                 


Pro Leu Leu Phe Ile Asp Pro 
305                 310     


<210> 26
<211> 693
<212> PRT
<213> Homo sapiens

<400> 26
Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Thr 
            260                 265                 270         


Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 
        275                 280                 285             


Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr 
305                 310                 315                 320 


Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His Gln 
                325                 330                 335     


Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu Asp 
            340                 345                 350         


Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Thr 
        355                 360                 365             


Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr Tyr 
    370                 375                 380                 


Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 
385                 390                 395                 400 


His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 
                405                 410                 415     


Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Val Pro Leu 
            420                 425                 430         


Pro Cys Arg Arg Lys Pro Arg Asp Tyr Thr Ile Lys Val His Met Asn 
        435                 440                 445             


Leu Leu Leu Ala Val Phe Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu 
    450                 455                 460                 


Pro Val Ala Leu Thr Gly Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile 
465                 470                 475                 480 


Phe Leu His Phe Ser Leu Leu Thr Cys Leu Ser Trp Met Gly Leu Glu 
                485                 490                 495     


Gly Tyr Asn Leu Tyr Arg Leu Val Val Glu Val Phe Gly Thr Tyr Val 
            500                 505                 510         


Pro Gly Tyr Leu Leu Lys Leu Ser Ala Met Gly Trp Gly Phe Pro Ile 
        515                 520                 525             


Phe Leu Val Thr Leu Val Ala Leu Val Asp Val Asp Asn Tyr Gly Pro 
    530                 535                 540                 


Ile Ile Leu Ala Val His Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser 
545                 550                 555                 560 


Met Cys Trp Ile Arg Asp Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly 
                565                 570                 575     


Leu Phe Ser Leu Val Phe Leu Phe Asn Met Ala Met Leu Ala Thr Met 
            580                 585                 590         


Val Val Gln Ile Leu Arg Leu Arg Pro His Thr Gln Lys Trp Ser His 
        595                 600                 605             


Val Leu Thr Leu Leu Gly Leu Ser Leu Val Leu Gly Leu Pro Trp Ala 
    610                 615                 620                 


Leu Ile Phe Phe Ser Phe Ala Ser Gly Thr Phe Gln Leu Val Val Leu 
625                 630                 635                 640 


Tyr Leu Phe Ser Ile Ile Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile 
                645                 650                 655     


Trp Tyr Trp Ser Met Arg Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu 
            660                 665                 670         


Lys Ser Asn Ser Asp Ser Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr 
        675                 680                 685             


Ser Ser Ser Arg Ile 
    690             


<210> 27
<211> 687
<212> PRT
<213> Homo sapiens

<400> 27
Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Thr 
            260                 265                 270         


Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 
        275                 280                 285             


Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr 
305                 310                 315                 320 


Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His Gln 
                325                 330                 335     


Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu Asp 
            340                 345                 350         


Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Thr 
        355                 360                 365             


Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr Tyr 
    370                 375                 380                 


Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 
385                 390                 395                 400 


His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 
                405                 410                 415     


Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Arg Lys Pro 
            420                 425                 430         


Arg Asp Tyr Thr Ile Lys Val His Met Asn Leu Leu Leu Ala Val Phe 
        435                 440                 445             


Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu Pro Val Ala Leu Thr Gly 
    450                 455                 460                 


Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile Phe Leu His Phe Ser Leu 
465                 470                 475                 480 


Leu Thr Cys Leu Ser Trp Met Gly Leu Glu Gly Tyr Asn Leu Tyr Arg 
                485                 490                 495     


Leu Val Val Glu Val Phe Gly Thr Tyr Val Pro Gly Tyr Leu Leu Lys 
            500                 505                 510         


Leu Ser Ala Met Gly Trp Gly Phe Pro Ile Phe Leu Val Thr Leu Val 
        515                 520                 525             


Ala Leu Val Asp Val Asp Asn Tyr Gly Pro Ile Ile Leu Ala Val His 
    530                 535                 540                 


Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser Met Cys Trp Ile Arg Asp 
545                 550                 555                 560 


Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly Leu Phe Ser Leu Val Phe 
                565                 570                 575     


Leu Phe Asn Met Ala Met Leu Ala Thr Met Val Val Gln Ile Leu Arg 
            580                 585                 590         


Leu Arg Pro His Thr Gln Lys Trp Ser His Val Leu Thr Leu Leu Gly 
        595                 600                 605             


Leu Ser Leu Val Leu Gly Leu Pro Trp Ala Leu Ile Phe Phe Ser Phe 
    610                 615                 620                 


Ala Ser Gly Thr Phe Gln Leu Val Val Leu Tyr Leu Phe Ser Ile Ile 
625                 630                 635                 640 


Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile Trp Tyr Trp Ser Met Arg 
                645                 650                 655     


Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu Lys Ser Asn Ser Asp Ser 
            660                 665                 670         


Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr Ser Ser Ser Arg Ile 
        675                 680                 685         


<210> 28
<211> 692
<212> PRT
<213> Homo sapiens

<400> 28
Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln 
        115                 120                 125             


His Gln Glu Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser 
    130                 135                 140                 


Val Thr Ser Trp Trp Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala 
145                 150                 155                 160 


Ser Phe Thr Phe Ser Phe His Ser Pro Pro His Thr Ala Ala His Asn 
                165                 170                 175     


Ala Ser Val Asp Met Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser 
            180                 185                 190         


Gln Phe Leu Lys His Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala 
        195                 200                 205             


Pro Ala Ser Gln Gln Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val 
    210                 215                 220                 


Arg Phe Met Gly Asp Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala 
225                 230                 235                 240 


Thr Val Trp Lys Leu Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile 
                245                 250                 255     


His Ser Arg Gln Glu Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val 
            260                 265                 270         


Leu Leu Pro Arg Thr Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu 
        275                 280                 285             


Ala Glu Lys Arg Leu Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe 
    290                 295                 300                 


Gln Asp Lys Asn Ser Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile 
305                 310                 315                 320 


Val Val Gln Asn Thr Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu 
                325                 330                 335     


Thr Phe Gln His Gln Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val 
            340                 345                 350         


Phe Trp Val Glu Asp Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser 
        355                 360                 365             


Ala Gly Cys Glu Thr Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys 
    370                 375                 380                 


Asn His Leu Thr Tyr Phe Ala Val Leu Met Val Ser Ser Val Glu Val 
385                 390                 395                 400 


Asp Ala Val His Lys His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys 
                405                 410                 415     


Val Val Ser Ala Leu Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys 
            420                 425                 430         


Ser Arg Arg Lys Pro Arg Asp Tyr Thr Ile Lys Val His Met Asn Leu 
        435                 440                 445             


Leu Leu Ala Val Phe Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu Pro 
    450                 455                 460                 


Val Ala Leu Thr Gly Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile Phe 
465                 470                 475                 480 


Leu His Phe Ser Leu Leu Thr Cys Leu Ser Trp Met Gly Leu Glu Gly 
                485                 490                 495     


Tyr Asn Leu Tyr Arg Leu Val Val Glu Val Phe Gly Thr Tyr Val Pro 
            500                 505                 510         


Gly Tyr Leu Leu Lys Leu Ser Ala Met Gly Trp Gly Phe Pro Ile Phe 
        515                 520                 525             


Leu Val Thr Leu Val Ala Leu Val Asp Val Asp Asn Tyr Gly Pro Ile 
    530                 535                 540                 


Ile Leu Ala Val His Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser Met 
545                 550                 555                 560 


Cys Trp Ile Arg Asp Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly Leu 
                565                 570                 575     


Phe Ser Leu Val Phe Leu Phe Asn Met Ala Met Leu Ala Thr Met Val 
            580                 585                 590         


Val Gln Ile Leu Arg Leu Arg Pro His Thr Gln Lys Trp Ser His Val 
        595                 600                 605             


Leu Thr Leu Leu Gly Leu Ser Leu Val Leu Gly Leu Pro Trp Ala Leu 
    610                 615                 620                 


Ile Phe Phe Ser Phe Ala Ser Gly Thr Phe Gln Leu Val Val Leu Tyr 
625                 630                 635                 640 


Leu Phe Ser Ile Ile Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile Trp 
                645                 650                 655     


Tyr Trp Ser Met Arg Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu Lys 
            660                 665                 670         


Ser Asn Ser Asp Ser Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr Ser 
        675                 680                 685             


Ser Ser Arg Ile 
    690         


<210> 29
<211> 523
<212> PRT
<213> Homo sapiens

<400> 29
Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Gln Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser 
        35                  40                  45              


Val Arg Phe Met Gly Asp Met Val Ser Phe Glu Glu Asp Arg Ile Asn 
    50                  55                  60                  


Ala Thr Val Trp Lys Leu Gln Pro Thr Ala Gly Leu Gln Asp Leu His 
65                  70                  75                  80  


Ile His Ser Arg Gln Glu Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser 
                85                  90                  95      


Val Leu Leu Pro Arg Thr Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly 
            100                 105                 110         


Glu Ala Glu Lys Arg Leu Leu Leu Val Asp Phe Ser Ser Gln Ala Leu 
        115                 120                 125             


Phe Gln Asp Lys Asn Ser Ser Gln Val Leu Gly Glu Lys Val Leu Gly 
    130                 135                 140                 


Ile Val Val Gln Asn Thr Lys Val Ala Asn Leu Thr Glu Pro Val Val 
145                 150                 155                 160 


Leu Thr Phe Gln His Gln Leu Gln Pro Lys Asn Val Thr Leu Gln Cys 
                165                 170                 175     


Val Phe Trp Val Glu Asp Pro Thr Leu Ser Ser Pro Gly His Trp Ser 
            180                 185                 190         


Ser Ala Gly Cys Glu Thr Val Arg Arg Glu Thr Gln Thr Ser Cys Phe 
        195                 200                 205             


Cys Asn His Leu Thr Tyr Phe Ala Val Leu Met Val Ser Ser Val Glu 
    210                 215                 220                 


Val Asp Ala Val His Lys His Tyr Leu Ser Leu Leu Ser Tyr Val Gly 
225                 230                 235                 240 


Cys Val Val Ser Ala Leu Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu 
                245                 250                 255     


Cys Ser Arg Val Pro Leu Pro Cys Arg Arg Lys Pro Arg Asp Tyr Thr 
            260                 265                 270         


Ile Lys Val His Met Asn Leu Leu Leu Ala Val Phe Leu Leu Asp Thr 
        275                 280                 285             


Ser Phe Leu Leu Ser Glu Pro Val Ala Leu Thr Gly Ser Glu Ala Gly 
    290                 295                 300                 


Cys Arg Ala Ser Ala Ile Phe Leu His Phe Ser Leu Leu Thr Cys Leu 
305                 310                 315                 320 


Ser Trp Met Gly Leu Glu Gly Tyr Asn Leu Tyr Arg Leu Val Val Glu 
                325                 330                 335     


Val Phe Gly Thr Tyr Val Pro Gly Tyr Leu Leu Lys Leu Ser Ala Met 
            340                 345                 350         


Gly Trp Gly Phe Pro Ile Phe Leu Val Thr Leu Val Ala Leu Val Asp 
        355                 360                 365             


Val Asp Asn Tyr Gly Pro Ile Ile Leu Ala Val His Arg Thr Pro Glu 
    370                 375                 380                 


Gly Val Ile Tyr Pro Ser Met Cys Trp Ile Arg Asp Ser Leu Val Ser 
385                 390                 395                 400 


Tyr Ile Thr Asn Leu Gly Leu Phe Ser Leu Val Phe Leu Phe Asn Met 
                405                 410                 415     


Ala Met Leu Ala Thr Met Val Val Gln Ile Leu Arg Leu Arg Pro His 
            420                 425                 430         


Thr Gln Lys Trp Ser His Val Leu Thr Leu Leu Gly Leu Ser Leu Val 
        435                 440                 445             


Leu Gly Leu Pro Trp Ala Leu Ile Phe Phe Ser Phe Ala Ser Gly Thr 
    450                 455                 460                 


Phe Gln Leu Val Val Leu Tyr Leu Phe Ser Ile Ile Thr Ser Phe Gln 
465                 470                 475                 480 


Gly Phe Leu Ile Phe Ile Trp Tyr Trp Ser Met Arg Leu Gln Ala Arg 
                485                 490                 495     


Gly Gly Pro Ser Pro Leu Lys Ser Asn Ser Asp Ser Ala Arg Leu Pro 
            500                 505                 510         


Ile Ser Ser Gly Ser Thr Ser Ser Ser Arg Ile 
        515                 520             


<210> 30
<211> 518
<212> PRT
<213> Homo sapiens

<400> 30
Met Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys 
1               5                   10                  15      


His Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln 
            20                  25                  30          


Gln Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly 
        35                  40                  45              


Asp Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys 
    50                  55                  60                  


Leu Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln 
65                  70                  75                  80  


Glu Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg 
                85                  90                  95      


Thr Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg 
            100                 105                 110         


Leu Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn 
        115                 120                 125             


Ser Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn 
    130                 135                 140                 


Thr Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His 
145                 150                 155                 160 


Gln Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu 
                165                 170                 175     


Asp Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu 
            180                 185                 190         


Thr Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr 
        195                 200                 205             


Tyr Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His 
    210                 215                 220                 


Lys His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala 
225                 230                 235                 240 


Leu Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Val Pro 
                245                 250                 255     


Leu Pro Cys Arg Arg Lys Pro Arg Asp Tyr Thr Ile Lys Val His Met 
            260                 265                 270         


Asn Leu Leu Leu Ala Val Phe Leu Leu Asp Thr Ser Phe Leu Leu Ser 
        275                 280                 285             


Glu Pro Val Ala Leu Thr Gly Ser Glu Ala Gly Cys Arg Ala Ser Ala 
    290                 295                 300                 


Ile Phe Leu His Phe Ser Leu Leu Thr Cys Leu Ser Trp Met Gly Leu 
305                 310                 315                 320 


Glu Gly Tyr Asn Leu Tyr Arg Leu Val Val Glu Val Phe Gly Thr Tyr 
                325                 330                 335     


Val Pro Gly Tyr Leu Leu Lys Leu Ser Ala Met Gly Trp Gly Phe Pro 
            340                 345                 350         


Ile Phe Leu Val Thr Leu Val Ala Leu Val Asp Val Asp Asn Tyr Gly 
        355                 360                 365             


Pro Ile Ile Leu Ala Val His Arg Thr Pro Glu Gly Val Ile Tyr Pro 
    370                 375                 380                 


Ser Met Cys Trp Ile Arg Asp Ser Leu Val Ser Tyr Ile Thr Asn Leu 
385                 390                 395                 400 


Gly Leu Phe Ser Leu Val Phe Leu Phe Asn Met Ala Met Leu Ala Thr 
                405                 410                 415     


Met Val Val Gln Ile Leu Arg Leu Arg Pro His Thr Gln Lys Trp Ser 
            420                 425                 430         


His Val Leu Thr Leu Leu Gly Leu Ser Leu Val Leu Gly Leu Pro Trp 
        435                 440                 445             


Ala Leu Ile Phe Phe Ser Phe Ala Ser Gly Thr Phe Gln Leu Val Val 
    450                 455                 460                 


Leu Tyr Leu Phe Ser Ile Ile Thr Ser Phe Gln Gly Phe Leu Ile Phe 
465                 470                 475                 480 


Ile Trp Tyr Trp Ser Met Arg Leu Gln Ala Arg Gly Gly Pro Ser Pro 
                485                 490                 495     


Leu Lys Ser Asn Ser Asp Ser Ala Arg Leu Pro Ile Ser Ser Gly Ser 
            500                 505                 510         


Thr Ser Ser Ser Arg Ile 
        515             


<210> 31
<211> 1447
<212> PRT
<213> Homo sapiens

<400> 31
Met Ala Ser Ala Gly Asn Ala Ala Glu Pro Gln Asp Arg Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Cys Ile Gly Ala Pro Gly Arg Pro Ala Gly Gly Gly Arg 
            20                  25                  30          


Arg Arg Arg Thr Gly Gly Leu Arg Arg Ala Ala Ala Pro Asp Arg Asp 
        35                  40                  45              


Tyr Leu His Arg Pro Ser Tyr Cys Asp Ala Ala Phe Ala Leu Glu Gln 
    50                  55                  60                  


Ile Ser Lys Gly Lys Ala Thr Gly Arg Lys Ala Pro Leu Trp Leu Arg 
65                  70                  75                  80  


Ala Lys Phe Gln Arg Leu Leu Phe Lys Leu Gly Cys Tyr Ile Gln Lys 
                85                  90                  95      


Asn Cys Gly Lys Phe Leu Val Val Gly Leu Leu Ile Phe Gly Ala Phe 
            100                 105                 110         


Ala Val Gly Leu Lys Ala Ala Asn Leu Glu Thr Asn Val Glu Glu Leu 
        115                 120                 125             


Trp Val Glu Val Gly Gly Arg Val Ser Arg Glu Leu Asn Tyr Thr Arg 
    130                 135                 140                 


Gln Lys Ile Gly Glu Glu Ala Met Phe Asn Pro Gln Leu Met Ile Gln 
145                 150                 155                 160 


Thr Pro Lys Glu Glu Gly Ala Asn Val Leu Thr Thr Glu Ala Leu Leu 
                165                 170                 175     


Gln His Leu Asp Ser Ala Leu Gln Ala Ser Arg Val His Val Tyr Met 
            180                 185                 190         


Tyr Asn Arg Gln Trp Lys Leu Glu His Leu Cys Tyr Lys Ser Gly Glu 
        195                 200                 205             


Leu Ile Thr Glu Thr Gly Tyr Met Asp Gln Ile Ile Glu Tyr Leu Tyr 
    210                 215                 220                 


Pro Cys Leu Ile Ile Thr Pro Leu Asp Cys Phe Trp Glu Gly Ala Lys 
225                 230                 235                 240 


Leu Gln Ser Gly Thr Ala Tyr Leu Leu Gly Lys Pro Pro Leu Arg Trp 
                245                 250                 255     


Thr Asn Phe Asp Pro Leu Glu Phe Leu Glu Glu Leu Lys Lys Ile Asn 
            260                 265                 270         


Tyr Gln Val Asp Ser Trp Glu Glu Met Leu Asn Lys Ala Glu Val Gly 
        275                 280                 285             


His Gly Tyr Met Asp Arg Pro Cys Leu Asn Pro Ala Asp Pro Asp Cys 
    290                 295                 300                 


Pro Ala Thr Ala Pro Asn Lys Asn Ser Thr Lys Pro Leu Asp Met Ala 
305                 310                 315                 320 


Leu Val Leu Asn Gly Gly Cys His Gly Leu Ser Arg Lys Tyr Met His 
                325                 330                 335     


Trp Gln Glu Glu Leu Ile Val Gly Gly Thr Val Lys Asn Ser Thr Gly 
            340                 345                 350         


Lys Leu Val Ser Ala His Ala Leu Gln Thr Met Phe Gln Leu Met Thr 
        355                 360                 365             


Pro Lys Gln Met Tyr Glu His Phe Lys Gly Tyr Glu Tyr Val Ser His 
    370                 375                 380                 


Ile Asn Trp Asn Glu Asp Lys Ala Ala Ala Ile Leu Glu Ala Trp Gln 
385                 390                 395                 400 


Arg Thr Tyr Val Glu Val Val His Gln Ser Val Ala Gln Asn Ser Thr 
                405                 410                 415     


Gln Lys Val Leu Ser Phe Thr Thr Thr Thr Leu Asp Asp Ile Leu Lys 
            420                 425                 430         


Ser Phe Ser Asp Val Ser Val Ile Arg Val Ala Ser Gly Tyr Leu Leu 
        435                 440                 445             


Met Leu Ala Tyr Ala Cys Leu Thr Met Leu Arg Trp Asp Cys Ser Lys 
    450                 455                 460                 


Ser Gln Gly Ala Val Gly Leu Ala Gly Val Leu Leu Val Ala Leu Ser 
465                 470                 475                 480 


Val Ala Ala Gly Leu Gly Leu Cys Ser Leu Ile Gly Ile Ser Phe Asn 
                485                 490                 495     


Ala Ala Thr Thr Gln Val Leu Pro Phe Leu Ala Leu Gly Val Gly Val 
            500                 505                 510         


Asp Asp Val Phe Leu Leu Ala His Ala Phe Ser Glu Thr Gly Gln Asn 
        515                 520                 525             


Lys Arg Ile Pro Phe Glu Asp Arg Thr Gly Glu Cys Leu Lys Arg Thr 
    530                 535                 540                 


Gly Ala Ser Val Ala Leu Thr Ser Ile Ser Asn Val Thr Ala Phe Phe 
545                 550                 555                 560 


Met Ala Ala Leu Ile Pro Ile Pro Ala Leu Arg Ala Phe Ser Leu Gln 
                565                 570                 575     


Ala Ala Val Val Val Val Phe Asn Phe Ala Met Val Leu Leu Ile Phe 
            580                 585                 590         


Pro Ala Ile Leu Ser Met Asp Leu Tyr Arg Arg Glu Asp Arg Arg Leu 
        595                 600                 605             


Asp Ile Phe Cys Cys Phe Thr Ser Pro Cys Val Ser Arg Val Ile Gln 
    610                 615                 620                 


Val Glu Pro Gln Ala Tyr Thr Asp Thr His Asp Asn Thr Arg Tyr Ser 
625                 630                 635                 640 


Pro Pro Pro Pro Tyr Ser Ser His Ser Phe Ala His Glu Thr Gln Ile 
                645                 650                 655     


Thr Met Gln Ser Thr Val Gln Leu Arg Thr Glu Tyr Asp Pro His Thr 
            660                 665                 670         


His Val Tyr Tyr Thr Thr Ala Glu Pro Arg Ser Glu Ile Ser Val Gln 
        675                 680                 685             


Pro Val Thr Val Thr Gln Asp Thr Leu Ser Cys Gln Ser Pro Glu Ser 
    690                 695                 700                 


Thr Ser Ser Thr Arg Asp Leu Leu Ser Gln Phe Ser Asp Ser Ser Leu 
705                 710                 715                 720 


His Cys Leu Glu Pro Pro Cys Thr Lys Trp Thr Leu Ser Ser Phe Ala 
                725                 730                 735     


Glu Lys His Tyr Ala Pro Phe Leu Leu Lys Pro Lys Ala Lys Val Val 
            740                 745                 750         


Val Ile Phe Leu Phe Leu Gly Leu Leu Gly Val Ser Leu Tyr Gly Thr 
        755                 760                 765             


Thr Arg Val Arg Asp Gly Leu Asp Leu Thr Asp Ile Val Pro Arg Glu 
    770                 775                 780                 


Thr Arg Glu Tyr Asp Phe Ile Ala Ala Gln Phe Lys Tyr Phe Ser Phe 
785                 790                 795                 800 


Tyr Asn Met Tyr Ile Val Thr Gln Lys Ala Asp Tyr Pro Asn Ile Gln 
                805                 810                 815     


His Leu Leu Tyr Asp Leu His Arg Ser Phe Ser Asn Val Lys Tyr Val 
            820                 825                 830         


Met Leu Glu Glu Asn Lys Gln Leu Pro Lys Met Trp Leu His Tyr Phe 
        835                 840                 845             


Arg Asp Trp Leu Gln Gly Leu Gln Asp Ala Phe Asp Ser Asp Trp Glu 
    850                 855                 860                 


Thr Gly Lys Ile Met Pro Asn Asn Tyr Lys Asn Gly Ser Asp Asp Gly 
865                 870                 875                 880 


Val Leu Ala Tyr Lys Leu Leu Val Gln Thr Gly Ser Arg Asp Lys Pro 
                885                 890                 895     


Ile Asp Ile Ser Gln Leu Thr Lys Gln Arg Leu Val Asp Ala Asp Gly 
            900                 905                 910         


Ile Ile Asn Pro Ser Ala Phe Tyr Ile Tyr Leu Thr Ala Trp Val Ser 
        915                 920                 925             


Asn Asp Pro Val Ala Tyr Ala Ala Ser Gln Ala Asn Ile Arg Pro His 
    930                 935                 940                 


Arg Pro Glu Trp Val His Asp Lys Ala Asp Tyr Met Pro Glu Thr Arg 
945                 950                 955                 960 


Leu Arg Ile Pro Ala Ala Glu Pro Ile Glu Tyr Ala Gln Phe Pro Phe 
                965                 970                 975     


Tyr Leu Asn Gly Leu Arg Asp Thr Ser Asp Phe Val Glu Ala Ile Glu 
            980                 985                 990         


Lys Val Arg Thr Ile Cys Ser Asn  Tyr Thr Ser Leu Gly  Leu Ser Ser 
        995                 1000                 1005             


Tyr Pro  Asn Gly Tyr Pro Phe  Leu Phe Trp Glu Gln  Tyr Ile Gly 
    1010                 1015                 1020             


Leu Arg  His Trp Leu Leu Leu  Phe Ile Ser Val Val  Leu Ala Cys 
    1025                 1030                 1035             


Thr Phe  Leu Val Cys Ala Val  Phe Leu Leu Asn Pro  Trp Thr Ala 
    1040                 1045                 1050             


Gly Ile  Ile Val Met Val Leu  Ala Leu Met Thr Val  Glu Leu Phe 
    1055                 1060                 1065             


Gly Met  Met Gly Leu Ile Gly  Ile Lys Leu Ser Ala  Val Pro Val 
    1070                 1075                 1080             


Val Ile  Leu Ile Ala Ser Val  Gly Ile Gly Val Glu  Phe Thr Val 
    1085                 1090                 1095             


His Val  Ala Leu Ala Phe Leu  Thr Ala Ile Gly Asp  Lys Asn Arg 
    1100                 1105                 1110             


Arg Ala  Val Leu Ala Leu Glu  His Met Phe Ala Pro  Val Leu Asp 
    1115                 1120                 1125             


Gly Ala  Val Ser Thr Leu Leu  Gly Val Leu Met Leu  Ala Gly Ser 
    1130                 1135                 1140             


Glu Phe  Asp Phe Ile Val Arg  Tyr Phe Phe Ala Val  Leu Ala Ile 
    1145                 1150                 1155             


Leu Thr  Ile Leu Gly Val Leu  Asn Gly Leu Val Leu  Leu Pro Val 
    1160                 1165                 1170             


Leu Leu  Ser Phe Phe Gly Pro  Tyr Pro Glu Val Ser  Pro Ala Asn 
    1175                 1180                 1185             


Gly Leu  Asn Arg Leu Pro Thr  Pro Ser Pro Glu Pro  Pro Pro Ser 
    1190                 1195                 1200             


Val Val  Arg Phe Ala Met Pro  Pro Gly His Thr His  Ser Gly Ser 
    1205                 1210                 1215             


Asp Ser  Ser Asp Ser Glu Tyr  Ser Ser Gln Thr Thr  Val Ser Gly 
    1220                 1225                 1230             


Leu Ser  Glu Glu Leu Arg His  Tyr Glu Ala Gln Gln  Gly Ala Gly 
    1235                 1240                 1245             


Gly Pro  Ala His Gln Val Ile  Val Glu Ala Thr Glu  Asn Pro Val 
    1250                 1255                 1260             


Phe Ala  His Ser Thr Val Val  His Pro Glu Ser Arg  His His Pro 
    1265                 1270                 1275             


Pro Ser  Asn Pro Arg Gln Gln  Pro His Leu Asp Ser  Gly Ser Leu 
    1280                 1285                 1290             


Pro Pro  Gly Arg Gln Gly Gln  Gln Pro Arg Arg Asp  Pro Pro Arg 
    1295                 1300                 1305             


Glu Gly  Leu Trp Pro Pro Pro  Tyr Arg Pro Arg Arg  Asp Ala Phe 
    1310                 1315                 1320             


Glu Ile  Ser Thr Glu Gly His  Ser Gly Pro Ser Asn  Arg Ala Arg 
    1325                 1330                 1335             


Trp Gly  Pro Arg Gly Ala Arg  Ser His Asn Pro Arg  Asn Pro Ala 
    1340                 1345                 1350             


Ser Thr  Ala Met Gly Ser Ser  Val Pro Gly Tyr Cys  Gln Pro Ile 
    1355                 1360                 1365             


Thr Thr  Val Thr Ala Ser Ala  Ser Val Thr Val Ala  Val His Pro 
    1370                 1375                 1380             


Pro Pro  Val Pro Gly Pro Gly  Arg Asn Pro Arg Gly  Gly Leu Cys 
    1385                 1390                 1395             


Pro Gly  Tyr Pro Glu Thr Asp  His Gly Leu Phe Glu  Asp Pro His 
    1400                 1405                 1410             


Val Pro  Phe His Val Arg Cys  Glu Arg Arg Asp Ser  Lys Val Glu 
    1415                 1420                 1425             


Val Ile  Glu Leu Gln Asp Val  Glu Cys Glu Glu Arg  Pro Arg Gly 
    1430                 1435                 1440             


Ser Ser  Ser Asn 
    1445         


<210> 32
<211> 1446
<212> PRT
<213> Homo sapiens

<400> 32
Met Glu Leu Leu Asn Arg Asn Arg Leu Val Ile Val Ser Pro Arg Cys 
1               5                   10                  15      


Thr Pro Pro Lys Ala Ser Gly Gly Pro Ala Arg Arg Gly Phe Tyr Thr 
            20                  25                  30          


Phe Arg Ser Phe Cys Lys Asp Gly Gly Gly Gly Glu Glu Glu Glu Glu 
        35                  40                  45              


Asn Gly Gly Glu Glu Lys Asp Asp Arg Gly Asp Lys Glu Thr Arg Ser 
    50                  55                  60                  


Asp Lys Gly Lys Ala Thr Gly Arg Lys Ala Pro Leu Trp Leu Arg Ala 
65                  70                  75                  80  


Lys Phe Gln Arg Leu Leu Phe Lys Leu Gly Cys Tyr Ile Gln Lys Asn 
                85                  90                  95      


Cys Gly Lys Phe Leu Val Val Gly Leu Leu Ile Phe Gly Ala Phe Ala 
            100                 105                 110         


Val Gly Leu Lys Ala Ala Asn Leu Glu Thr Asn Val Glu Glu Leu Trp 
        115                 120                 125             


Val Glu Val Gly Gly Arg Val Ser Arg Glu Leu Asn Tyr Thr Arg Gln 
    130                 135                 140                 


Lys Ile Gly Glu Glu Ala Met Phe Asn Pro Gln Leu Met Ile Gln Thr 
145                 150                 155                 160 


Pro Lys Glu Glu Gly Ala Asn Val Leu Thr Thr Glu Ala Leu Leu Gln 
                165                 170                 175     


His Leu Asp Ser Ala Leu Gln Ala Ser Arg Val His Val Tyr Met Tyr 
            180                 185                 190         


Asn Arg Gln Trp Lys Leu Glu His Leu Cys Tyr Lys Ser Gly Glu Leu 
        195                 200                 205             


Ile Thr Glu Thr Gly Tyr Met Asp Gln Ile Ile Glu Tyr Leu Tyr Pro 
    210                 215                 220                 


Cys Leu Ile Ile Thr Pro Leu Asp Cys Phe Trp Glu Gly Ala Lys Leu 
225                 230                 235                 240 


Gln Ser Gly Thr Ala Tyr Leu Leu Gly Lys Pro Pro Leu Arg Trp Thr 
                245                 250                 255     


Asn Phe Asp Pro Leu Glu Phe Leu Glu Glu Leu Lys Lys Ile Asn Tyr 
            260                 265                 270         


Gln Val Asp Ser Trp Glu Glu Met Leu Asn Lys Ala Glu Val Gly His 
        275                 280                 285             


Gly Tyr Met Asp Arg Pro Cys Leu Asn Pro Ala Asp Pro Asp Cys Pro 
    290                 295                 300                 


Ala Thr Ala Pro Asn Lys Asn Ser Thr Lys Pro Leu Asp Met Ala Leu 
305                 310                 315                 320 


Val Leu Asn Gly Gly Cys His Gly Leu Ser Arg Lys Tyr Met His Trp 
                325                 330                 335     


Gln Glu Glu Leu Ile Val Gly Gly Thr Val Lys Asn Ser Thr Gly Lys 
            340                 345                 350         


Leu Val Ser Ala His Ala Leu Gln Thr Met Phe Gln Leu Met Thr Pro 
        355                 360                 365             


Lys Gln Met Tyr Glu His Phe Lys Gly Tyr Glu Tyr Val Ser His Ile 
    370                 375                 380                 


Asn Trp Asn Glu Asp Lys Ala Ala Ala Ile Leu Glu Ala Trp Gln Arg 
385                 390                 395                 400 


Thr Tyr Val Glu Val Val His Gln Ser Val Ala Gln Asn Ser Thr Gln 
                405                 410                 415     


Lys Val Leu Ser Phe Thr Thr Thr Thr Leu Asp Asp Ile Leu Lys Ser 
            420                 425                 430         


Phe Ser Asp Val Ser Val Ile Arg Val Ala Ser Gly Tyr Leu Leu Met 
        435                 440                 445             


Leu Ala Tyr Ala Cys Leu Thr Met Leu Arg Trp Asp Cys Ser Lys Ser 
    450                 455                 460                 


Gln Gly Ala Val Gly Leu Ala Gly Val Leu Leu Val Ala Leu Ser Val 
465                 470                 475                 480 


Ala Ala Gly Leu Gly Leu Cys Ser Leu Ile Gly Ile Ser Phe Asn Ala 
                485                 490                 495     


Ala Thr Thr Gln Val Leu Pro Phe Leu Ala Leu Gly Val Gly Val Asp 
            500                 505                 510         


Asp Val Phe Leu Leu Ala His Ala Phe Ser Glu Thr Gly Gln Asn Lys 
        515                 520                 525             


Arg Ile Pro Phe Glu Asp Arg Thr Gly Glu Cys Leu Lys Arg Thr Gly 
    530                 535                 540                 


Ala Ser Val Ala Leu Thr Ser Ile Ser Asn Val Thr Ala Phe Phe Met 
545                 550                 555                 560 


Ala Ala Leu Ile Pro Ile Pro Ala Leu Arg Ala Phe Ser Leu Gln Ala 
                565                 570                 575     


Ala Val Val Val Val Phe Asn Phe Ala Met Val Leu Leu Ile Phe Pro 
            580                 585                 590         


Ala Ile Leu Ser Met Asp Leu Tyr Arg Arg Glu Asp Arg Arg Leu Asp 
        595                 600                 605             


Ile Phe Cys Cys Phe Thr Ser Pro Cys Val Ser Arg Val Ile Gln Val 
    610                 615                 620                 


Glu Pro Gln Ala Tyr Thr Asp Thr His Asp Asn Thr Arg Tyr Ser Pro 
625                 630                 635                 640 


Pro Pro Pro Tyr Ser Ser His Ser Phe Ala His Glu Thr Gln Ile Thr 
                645                 650                 655     


Met Gln Ser Thr Val Gln Leu Arg Thr Glu Tyr Asp Pro His Thr His 
            660                 665                 670         


Val Tyr Tyr Thr Thr Ala Glu Pro Arg Ser Glu Ile Ser Val Gln Pro 
        675                 680                 685             


Val Thr Val Thr Gln Asp Thr Leu Ser Cys Gln Ser Pro Glu Ser Thr 
    690                 695                 700                 


Ser Ser Thr Arg Asp Leu Leu Ser Gln Phe Ser Asp Ser Ser Leu His 
705                 710                 715                 720 


Cys Leu Glu Pro Pro Cys Thr Lys Trp Thr Leu Ser Ser Phe Ala Glu 
                725                 730                 735     


Lys His Tyr Ala Pro Phe Leu Leu Lys Pro Lys Ala Lys Val Val Val 
            740                 745                 750         


Ile Phe Leu Phe Leu Gly Leu Leu Gly Val Ser Leu Tyr Gly Thr Thr 
        755                 760                 765             


Arg Val Arg Asp Gly Leu Asp Leu Thr Asp Ile Val Pro Arg Glu Thr 
    770                 775                 780                 


Arg Glu Tyr Asp Phe Ile Ala Ala Gln Phe Lys Tyr Phe Ser Phe Tyr 
785                 790                 795                 800 


Asn Met Tyr Ile Val Thr Gln Lys Ala Asp Tyr Pro Asn Ile Gln His 
                805                 810                 815     


Leu Leu Tyr Asp Leu His Arg Ser Phe Ser Asn Val Lys Tyr Val Met 
            820                 825                 830         


Leu Glu Glu Asn Lys Gln Leu Pro Lys Met Trp Leu His Tyr Phe Arg 
        835                 840                 845             


Asp Trp Leu Gln Gly Leu Gln Asp Ala Phe Asp Ser Asp Trp Glu Thr 
    850                 855                 860                 


Gly Lys Ile Met Pro Asn Asn Tyr Lys Asn Gly Ser Asp Asp Gly Val 
865                 870                 875                 880 


Leu Ala Tyr Lys Leu Leu Val Gln Thr Gly Ser Arg Asp Lys Pro Ile 
                885                 890                 895     


Asp Ile Ser Gln Leu Thr Lys Gln Arg Leu Val Asp Ala Asp Gly Ile 
            900                 905                 910         


Ile Asn Pro Ser Ala Phe Tyr Ile Tyr Leu Thr Ala Trp Val Ser Asn 
        915                 920                 925             


Asp Pro Val Ala Tyr Ala Ala Ser Gln Ala Asn Ile Arg Pro His Arg 
    930                 935                 940                 


Pro Glu Trp Val His Asp Lys Ala Asp Tyr Met Pro Glu Thr Arg Leu 
945                 950                 955                 960 


Arg Ile Pro Ala Ala Glu Pro Ile Glu Tyr Ala Gln Phe Pro Phe Tyr 
                965                 970                 975     


Leu Asn Gly Leu Arg Asp Thr Ser Asp Phe Val Glu Ala Ile Glu Lys 
            980                 985                 990         


Val Arg Thr Ile Cys Ser Asn Tyr  Thr Ser Leu Gly Leu  Ser Ser Tyr 
        995                 1000                 1005             


Pro Asn  Gly Tyr Pro Phe Leu  Phe Trp Glu Gln Tyr  Ile Gly Leu 
    1010                 1015                 1020             


Arg His  Trp Leu Leu Leu Phe  Ile Ser Val Val Leu  Ala Cys Thr 
    1025                 1030                 1035             


Phe Leu  Val Cys Ala Val Phe  Leu Leu Asn Pro Trp  Thr Ala Gly 
    1040                 1045                 1050             


Ile Ile  Val Met Val Leu Ala  Leu Met Thr Val Glu  Leu Phe Gly 
    1055                 1060                 1065             


Met Met  Gly Leu Ile Gly Ile  Lys Leu Ser Ala Val  Pro Val Val 
    1070                 1075                 1080             


Ile Leu  Ile Ala Ser Val Gly  Ile Gly Val Glu Phe  Thr Val His 
    1085                 1090                 1095             


Val Ala  Leu Ala Phe Leu Thr  Ala Ile Gly Asp Lys  Asn Arg Arg 
    1100                 1105                 1110             


Ala Val  Leu Ala Leu Glu His  Met Phe Ala Pro Val  Leu Asp Gly 
    1115                 1120                 1125             


Ala Val  Ser Thr Leu Leu Gly  Val Leu Met Leu Ala  Gly Ser Glu 
    1130                 1135                 1140             


Phe Asp  Phe Ile Val Arg Tyr  Phe Phe Ala Val Leu  Ala Ile Leu 
    1145                 1150                 1155             


Thr Ile  Leu Gly Val Leu Asn  Gly Leu Val Leu Leu  Pro Val Leu 
    1160                 1165                 1170             


Leu Ser  Phe Phe Gly Pro Tyr  Pro Glu Val Ser Pro  Ala Asn Gly 
    1175                 1180                 1185             


Leu Asn  Arg Leu Pro Thr Pro  Ser Pro Glu Pro Pro  Pro Ser Val 
    1190                 1195                 1200             


Val Arg  Phe Ala Met Pro Pro  Gly His Thr His Ser  Gly Ser Asp 
    1205                 1210                 1215             


Ser Ser  Asp Ser Glu Tyr Ser  Ser Gln Thr Thr Val  Ser Gly Leu 
    1220                 1225                 1230             


Ser Glu  Glu Leu Arg His Tyr  Glu Ala Gln Gln Gly  Ala Gly Gly 
    1235                 1240                 1245             


Pro Ala  His Gln Val Ile Val  Glu Ala Thr Glu Asn  Pro Val Phe 
    1250                 1255                 1260             


Ala His  Ser Thr Val Val His  Pro Glu Ser Arg His  His Pro Pro 
    1265                 1270                 1275             


Ser Asn  Pro Arg Gln Gln Pro  His Leu Asp Ser Gly  Ser Leu Pro 
    1280                 1285                 1290             


Pro Gly  Arg Gln Gly Gln Gln  Pro Arg Arg Asp Pro  Pro Arg Glu 
    1295                 1300                 1305             


Gly Leu  Trp Pro Pro Pro Tyr  Arg Pro Arg Arg Asp  Ala Phe Glu 
    1310                 1315                 1320             


Ile Ser  Thr Glu Gly His Ser  Gly Pro Ser Asn Arg  Ala Arg Trp 
    1325                 1330                 1335             


Gly Pro  Arg Gly Ala Arg Ser  His Asn Pro Arg Asn  Pro Ala Ser 
    1340                 1345                 1350             


Thr Ala  Met Gly Ser Ser Val  Pro Gly Tyr Cys Gln  Pro Ile Thr 
    1355                 1360                 1365             


Thr Val  Thr Ala Ser Ala Ser  Val Thr Val Ala Val  His Pro Pro 
    1370                 1375                 1380             


Pro Val  Pro Gly Pro Gly Arg  Asn Pro Arg Gly Gly  Leu Cys Pro 
    1385                 1390                 1395             


Gly Tyr  Pro Glu Thr Asp His  Gly Leu Phe Glu Asp  Pro His Val 
    1400                 1405                 1410             


Pro Phe  His Val Arg Cys Glu  Arg Arg Asp Ser Lys  Val Glu Val 
    1415                 1420                 1425             


Ile Glu  Leu Gln Asp Val Glu  Cys Glu Glu Arg Pro  Arg Gly Ser 
    1430                 1435                 1440             


Ser Ser  Asn 
    1445     


<210> 33
<211> 1381
<212> PRT
<213> Homo sapiens

<400> 33
Met Gly Lys Ala Thr Gly Arg Lys Ala Pro Leu Trp Leu Arg Ala Lys 
1               5                   10                  15      


Phe Gln Arg Leu Leu Phe Lys Leu Gly Cys Tyr Ile Gln Lys Asn Cys 
            20                  25                  30          


Gly Lys Phe Leu Val Val Gly Leu Leu Ile Phe Gly Ala Phe Ala Val 
        35                  40                  45              


Gly Leu Lys Ala Ala Asn Leu Glu Thr Asn Val Glu Glu Leu Trp Val 
    50                  55                  60                  


Glu Val Gly Gly Arg Val Ser Arg Glu Leu Asn Tyr Thr Arg Gln Lys 
65                  70                  75                  80  


Ile Gly Glu Glu Ala Met Phe Asn Pro Gln Leu Met Ile Gln Thr Pro 
                85                  90                  95      


Lys Glu Glu Gly Ala Asn Val Leu Thr Thr Glu Ala Leu Leu Gln His 
            100                 105                 110         


Leu Asp Ser Ala Leu Gln Ala Ser Arg Val His Val Tyr Met Tyr Asn 
        115                 120                 125             


Arg Gln Trp Lys Leu Glu His Leu Cys Tyr Lys Ser Gly Glu Leu Ile 
    130                 135                 140                 


Thr Glu Thr Gly Tyr Met Asp Gln Ile Ile Glu Tyr Leu Tyr Pro Cys 
145                 150                 155                 160 


Leu Ile Ile Thr Pro Leu Asp Cys Phe Trp Glu Gly Ala Lys Leu Gln 
                165                 170                 175     


Ser Gly Thr Ala Tyr Leu Leu Gly Lys Pro Pro Leu Arg Trp Thr Asn 
            180                 185                 190         


Phe Asp Pro Leu Glu Phe Leu Glu Glu Leu Lys Lys Ile Asn Tyr Gln 
        195                 200                 205             


Val Asp Ser Trp Glu Glu Met Leu Asn Lys Ala Glu Val Gly His Gly 
    210                 215                 220                 


Tyr Met Asp Arg Pro Cys Leu Asn Pro Ala Asp Pro Asp Cys Pro Ala 
225                 230                 235                 240 


Thr Ala Pro Asn Lys Asn Ser Thr Lys Pro Leu Asp Met Ala Leu Val 
                245                 250                 255     


Leu Asn Gly Gly Cys His Gly Leu Ser Arg Lys Tyr Met His Trp Gln 
            260                 265                 270         


Glu Glu Leu Ile Val Gly Gly Thr Val Lys Asn Ser Thr Gly Lys Leu 
        275                 280                 285             


Val Ser Ala His Ala Leu Gln Thr Met Phe Gln Leu Met Thr Pro Lys 
    290                 295                 300                 


Gln Met Tyr Glu His Phe Lys Gly Tyr Glu Tyr Val Ser His Ile Asn 
305                 310                 315                 320 


Trp Asn Glu Asp Lys Ala Ala Ala Ile Leu Glu Ala Trp Gln Arg Thr 
                325                 330                 335     


Tyr Val Glu Val Val His Gln Ser Val Ala Gln Asn Ser Thr Gln Lys 
            340                 345                 350         


Val Leu Ser Phe Thr Thr Thr Thr Leu Asp Asp Ile Leu Lys Ser Phe 
        355                 360                 365             


Ser Asp Val Ser Val Ile Arg Val Ala Ser Gly Tyr Leu Leu Met Leu 
    370                 375                 380                 


Ala Tyr Ala Cys Leu Thr Met Leu Arg Trp Asp Cys Ser Lys Ser Gln 
385                 390                 395                 400 


Gly Ala Val Gly Leu Ala Gly Val Leu Leu Val Ala Leu Ser Val Ala 
                405                 410                 415     


Ala Gly Leu Gly Leu Cys Ser Leu Ile Gly Ile Ser Phe Asn Ala Ala 
            420                 425                 430         


Thr Thr Gln Val Leu Pro Phe Leu Ala Leu Gly Val Gly Val Asp Asp 
        435                 440                 445             


Val Phe Leu Leu Ala His Ala Phe Ser Glu Thr Gly Gln Asn Lys Arg 
    450                 455                 460                 


Ile Pro Phe Glu Asp Arg Thr Gly Glu Cys Leu Lys Arg Thr Gly Ala 
465                 470                 475                 480 


Ser Val Ala Leu Thr Ser Ile Ser Asn Val Thr Ala Phe Phe Met Ala 
                485                 490                 495     


Ala Leu Ile Pro Ile Pro Ala Leu Arg Ala Phe Ser Leu Gln Ala Ala 
            500                 505                 510         


Val Val Val Val Phe Asn Phe Ala Met Val Leu Leu Ile Phe Pro Ala 
        515                 520                 525             


Ile Leu Ser Met Asp Leu Tyr Arg Arg Glu Asp Arg Arg Leu Asp Ile 
    530                 535                 540                 


Phe Cys Cys Phe Thr Ser Pro Cys Val Ser Arg Val Ile Gln Val Glu 
545                 550                 555                 560 


Pro Gln Ala Tyr Thr Asp Thr His Asp Asn Thr Arg Tyr Ser Pro Pro 
                565                 570                 575     


Pro Pro Tyr Ser Ser His Ser Phe Ala His Glu Thr Gln Ile Thr Met 
            580                 585                 590         


Gln Ser Thr Val Gln Leu Arg Thr Glu Tyr Asp Pro His Thr His Val 
        595                 600                 605             


Tyr Tyr Thr Thr Ala Glu Pro Arg Ser Glu Ile Ser Val Gln Pro Val 
    610                 615                 620                 


Thr Val Thr Gln Asp Thr Leu Ser Cys Gln Ser Pro Glu Ser Thr Ser 
625                 630                 635                 640 


Ser Thr Arg Asp Leu Leu Ser Gln Phe Ser Asp Ser Ser Leu His Cys 
                645                 650                 655     


Leu Glu Pro Pro Cys Thr Lys Trp Thr Leu Ser Ser Phe Ala Glu Lys 
            660                 665                 670         


His Tyr Ala Pro Phe Leu Leu Lys Pro Lys Ala Lys Val Val Val Ile 
        675                 680                 685             


Phe Leu Phe Leu Gly Leu Leu Gly Val Ser Leu Tyr Gly Thr Thr Arg 
    690                 695                 700                 


Val Arg Asp Gly Leu Asp Leu Thr Asp Ile Val Pro Arg Glu Thr Arg 
705                 710                 715                 720 


Glu Tyr Asp Phe Ile Ala Ala Gln Phe Lys Tyr Phe Ser Phe Tyr Asn 
                725                 730                 735     


Met Tyr Ile Val Thr Gln Lys Ala Asp Tyr Pro Asn Ile Gln His Leu 
            740                 745                 750         


Leu Tyr Asp Leu His Arg Ser Phe Ser Asn Val Lys Tyr Val Met Leu 
        755                 760                 765             


Glu Glu Asn Lys Gln Leu Pro Lys Met Trp Leu His Tyr Phe Arg Asp 
    770                 775                 780                 


Trp Leu Gln Gly Leu Gln Asp Ala Phe Asp Ser Asp Trp Glu Thr Gly 
785                 790                 795                 800 


Lys Ile Met Pro Asn Asn Tyr Lys Asn Gly Ser Asp Asp Gly Val Leu 
                805                 810                 815     


Ala Tyr Lys Leu Leu Val Gln Thr Gly Ser Arg Asp Lys Pro Ile Asp 
            820                 825                 830         


Ile Ser Gln Leu Thr Lys Gln Arg Leu Val Asp Ala Asp Gly Ile Ile 
        835                 840                 845             


Asn Pro Ser Ala Phe Tyr Ile Tyr Leu Thr Ala Trp Val Ser Asn Asp 
    850                 855                 860                 


Pro Val Ala Tyr Ala Ala Ser Gln Ala Asn Ile Arg Pro His Arg Pro 
865                 870                 875                 880 


Glu Trp Val His Asp Lys Ala Asp Tyr Met Pro Glu Thr Arg Leu Arg 
                885                 890                 895     


Ile Pro Ala Ala Glu Pro Ile Glu Tyr Ala Gln Phe Pro Phe Tyr Leu 
            900                 905                 910         


Asn Gly Leu Arg Asp Thr Ser Asp Phe Val Glu Ala Ile Glu Lys Val 
        915                 920                 925             


Arg Thr Ile Cys Ser Asn Tyr Thr Ser Leu Gly Leu Ser Ser Tyr Pro 
    930                 935                 940                 


Asn Gly Tyr Pro Phe Leu Phe Trp Glu Gln Tyr Ile Gly Leu Arg His 
945                 950                 955                 960 


Trp Leu Leu Leu Phe Ile Ser Val Val Leu Ala Cys Thr Phe Leu Val 
                965                 970                 975     


Cys Ala Val Phe Leu Leu Asn Pro Trp Thr Ala Gly Ile Ile Val Met 
            980                 985                 990         


Val Leu Ala Leu Met Thr Val Glu  Leu Phe Gly Met Met  Gly Leu Ile 
        995                 1000                 1005             


Gly Ile  Lys Leu Ser Ala Val  Pro Val Val Ile Leu  Ile Ala Ser 
    1010                 1015                 1020             


Val Gly  Ile Gly Val Glu Phe  Thr Val His Val Ala  Leu Ala Phe 
    1025                 1030                 1035             


Leu Thr  Ala Ile Gly Asp Lys  Asn Arg Arg Ala Val  Leu Ala Leu 
    1040                 1045                 1050             


Glu His  Met Phe Ala Pro Val  Leu Asp Gly Ala Val  Ser Thr Leu 
    1055                 1060                 1065             


Leu Gly  Val Leu Met Leu Ala  Gly Ser Glu Phe Asp  Phe Ile Val 
    1070                 1075                 1080             


Arg Tyr  Phe Phe Ala Val Leu  Ala Ile Leu Thr Ile  Leu Gly Val 
    1085                 1090                 1095             


Leu Asn  Gly Leu Val Leu Leu  Pro Val Leu Leu Ser  Phe Phe Gly 
    1100                 1105                 1110             


Pro Tyr  Pro Glu Val Ser Pro  Ala Asn Gly Leu Asn  Arg Leu Pro 
    1115                 1120                 1125             


Thr Pro  Ser Pro Glu Pro Pro  Pro Ser Val Val Arg  Phe Ala Met 
    1130                 1135                 1140             


Pro Pro  Gly His Thr His Ser  Gly Ser Asp Ser Ser  Asp Ser Glu 
    1145                 1150                 1155             


Tyr Ser  Ser Gln Thr Thr Val  Ser Gly Leu Ser Glu  Glu Leu Arg 
    1160                 1165                 1170             


His Tyr  Glu Ala Gln Gln Gly  Ala Gly Gly Pro Ala  His Gln Val 
    1175                 1180                 1185             


Ile Val  Glu Ala Thr Glu Asn  Pro Val Phe Ala His  Ser Thr Val 
    1190                 1195                 1200             


Val His  Pro Glu Ser Arg His  His Pro Pro Ser Asn  Pro Arg Gln 
    1205                 1210                 1215             


Gln Pro  His Leu Asp Ser Gly  Ser Leu Pro Pro Gly  Arg Gln Gly 
    1220                 1225                 1230             


Gln Gln  Pro Arg Arg Asp Pro  Pro Arg Glu Gly Leu  Trp Pro Pro 
    1235                 1240                 1245             


Pro Tyr  Arg Pro Arg Arg Asp  Ala Phe Glu Ile Ser  Thr Glu Gly 
    1250                 1255                 1260             


His Ser  Gly Pro Ser Asn Arg  Ala Arg Trp Gly Pro  Arg Gly Ala 
    1265                 1270                 1275             


Arg Ser  His Asn Pro Arg Asn  Pro Ala Ser Thr Ala  Met Gly Ser 
    1280                 1285                 1290             


Ser Val  Pro Gly Tyr Cys Gln  Pro Ile Thr Thr Val  Thr Ala Ser 
    1295                 1300                 1305             


Ala Ser  Val Thr Val Ala Val  His Pro Pro Pro Val  Pro Gly Pro 
    1310                 1315                 1320             


Gly Arg  Asn Pro Arg Gly Gly  Leu Cys Pro Gly Tyr  Pro Glu Thr 
    1325                 1330                 1335             


Asp His  Gly Leu Phe Glu Asp  Pro His Val Pro Phe  His Val Arg 
    1340                 1345                 1350             


Cys Glu  Arg Arg Asp Ser Lys  Val Glu Val Ile Glu  Leu Gln Asp 
    1355                 1360                 1365             


Val Glu  Cys Glu Glu Arg Pro  Arg Gly Ser Ser Ser  Asn 
    1370                 1375                 1380     


<210> 34
<211> 1296
<212> PRT
<213> Homo sapiens

<400> 34
Met Phe Asn Pro Gln Leu Met Ile Gln Thr Pro Lys Glu Glu Gly Ala 
1               5                   10                  15      


Asn Val Leu Thr Thr Glu Ala Leu Leu Gln His Leu Asp Ser Ala Leu 
            20                  25                  30          


Gln Ala Ser Arg Val His Val Tyr Met Tyr Asn Arg Gln Trp Lys Leu 
        35                  40                  45              


Glu His Leu Cys Tyr Lys Ser Gly Glu Leu Ile Thr Glu Thr Gly Tyr 
    50                  55                  60                  


Met Asp Gln Ile Ile Glu Tyr Leu Tyr Pro Cys Leu Ile Ile Thr Pro 
65                  70                  75                  80  


Leu Asp Cys Phe Trp Glu Gly Ala Lys Leu Gln Ser Gly Thr Ala Tyr 
                85                  90                  95      


Leu Leu Gly Lys Pro Pro Leu Arg Trp Thr Asn Phe Asp Pro Leu Glu 
            100                 105                 110         


Phe Leu Glu Glu Leu Lys Lys Ile Asn Tyr Gln Val Asp Ser Trp Glu 
        115                 120                 125             


Glu Met Leu Asn Lys Ala Glu Val Gly His Gly Tyr Met Asp Arg Pro 
    130                 135                 140                 


Cys Leu Asn Pro Ala Asp Pro Asp Cys Pro Ala Thr Ala Pro Asn Lys 
145                 150                 155                 160 


Asn Ser Thr Lys Pro Leu Asp Met Ala Leu Val Leu Asn Gly Gly Cys 
                165                 170                 175     


His Gly Leu Ser Arg Lys Tyr Met His Trp Gln Glu Glu Leu Ile Val 
            180                 185                 190         


Gly Gly Thr Val Lys Asn Ser Thr Gly Lys Leu Val Ser Ala His Ala 
        195                 200                 205             


Leu Gln Thr Met Phe Gln Leu Met Thr Pro Lys Gln Met Tyr Glu His 
    210                 215                 220                 


Phe Lys Gly Tyr Glu Tyr Val Ser His Ile Asn Trp Asn Glu Asp Lys 
225                 230                 235                 240 


Ala Ala Ala Ile Leu Glu Ala Trp Gln Arg Thr Tyr Val Glu Val Val 
                245                 250                 255     


His Gln Ser Val Ala Gln Asn Ser Thr Gln Lys Val Leu Ser Phe Thr 
            260                 265                 270         


Thr Thr Thr Leu Asp Asp Ile Leu Lys Ser Phe Ser Asp Val Ser Val 
        275                 280                 285             


Ile Arg Val Ala Ser Gly Tyr Leu Leu Met Leu Ala Tyr Ala Cys Leu 
    290                 295                 300                 


Thr Met Leu Arg Trp Asp Cys Ser Lys Ser Gln Gly Ala Val Gly Leu 
305                 310                 315                 320 


Ala Gly Val Leu Leu Val Ala Leu Ser Val Ala Ala Gly Leu Gly Leu 
                325                 330                 335     


Cys Ser Leu Ile Gly Ile Ser Phe Asn Ala Ala Thr Thr Gln Val Leu 
            340                 345                 350         


Pro Phe Leu Ala Leu Gly Val Gly Val Asp Asp Val Phe Leu Leu Ala 
        355                 360                 365             


His Ala Phe Ser Glu Thr Gly Gln Asn Lys Arg Ile Pro Phe Glu Asp 
    370                 375                 380                 


Arg Thr Gly Glu Cys Leu Lys Arg Thr Gly Ala Ser Val Ala Leu Thr 
385                 390                 395                 400 


Ser Ile Ser Asn Val Thr Ala Phe Phe Met Ala Ala Leu Ile Pro Ile 
                405                 410                 415     


Pro Ala Leu Arg Ala Phe Ser Leu Gln Ala Ala Val Val Val Val Phe 
            420                 425                 430         


Asn Phe Ala Met Val Leu Leu Ile Phe Pro Ala Ile Leu Ser Met Asp 
        435                 440                 445             


Leu Tyr Arg Arg Glu Asp Arg Arg Leu Asp Ile Phe Cys Cys Phe Thr 
    450                 455                 460                 


Ser Pro Cys Val Ser Arg Val Ile Gln Val Glu Pro Gln Ala Tyr Thr 
465                 470                 475                 480 


Asp Thr His Asp Asn Thr Arg Tyr Ser Pro Pro Pro Pro Tyr Ser Ser 
                485                 490                 495     


His Ser Phe Ala His Glu Thr Gln Ile Thr Met Gln Ser Thr Val Gln 
            500                 505                 510         


Leu Arg Thr Glu Tyr Asp Pro His Thr His Val Tyr Tyr Thr Thr Ala 
        515                 520                 525             


Glu Pro Arg Ser Glu Ile Ser Val Gln Pro Val Thr Val Thr Gln Asp 
    530                 535                 540                 


Thr Leu Ser Cys Gln Ser Pro Glu Ser Thr Ser Ser Thr Arg Asp Leu 
545                 550                 555                 560 


Leu Ser Gln Phe Ser Asp Ser Ser Leu His Cys Leu Glu Pro Pro Cys 
                565                 570                 575     


Thr Lys Trp Thr Leu Ser Ser Phe Ala Glu Lys His Tyr Ala Pro Phe 
            580                 585                 590         


Leu Leu Lys Pro Lys Ala Lys Val Val Val Ile Phe Leu Phe Leu Gly 
        595                 600                 605             


Leu Leu Gly Val Ser Leu Tyr Gly Thr Thr Arg Val Arg Asp Gly Leu 
    610                 615                 620                 


Asp Leu Thr Asp Ile Val Pro Arg Glu Thr Arg Glu Tyr Asp Phe Ile 
625                 630                 635                 640 


Ala Ala Gln Phe Lys Tyr Phe Ser Phe Tyr Asn Met Tyr Ile Val Thr 
                645                 650                 655     


Gln Lys Ala Asp Tyr Pro Asn Ile Gln His Leu Leu Tyr Asp Leu His 
            660                 665                 670         


Arg Ser Phe Ser Asn Val Lys Tyr Val Met Leu Glu Glu Asn Lys Gln 
        675                 680                 685             


Leu Pro Lys Met Trp Leu His Tyr Phe Arg Asp Trp Leu Gln Gly Leu 
    690                 695                 700                 


Gln Asp Ala Phe Asp Ser Asp Trp Glu Thr Gly Lys Ile Met Pro Asn 
705                 710                 715                 720 


Asn Tyr Lys Asn Gly Ser Asp Asp Gly Val Leu Ala Tyr Lys Leu Leu 
                725                 730                 735     


Val Gln Thr Gly Ser Arg Asp Lys Pro Ile Asp Ile Ser Gln Leu Thr 
            740                 745                 750         


Lys Gln Arg Leu Val Asp Ala Asp Gly Ile Ile Asn Pro Ser Ala Phe 
        755                 760                 765             


Tyr Ile Tyr Leu Thr Ala Trp Val Ser Asn Asp Pro Val Ala Tyr Ala 
    770                 775                 780                 


Ala Ser Gln Ala Asn Ile Arg Pro His Arg Pro Glu Trp Val His Asp 
785                 790                 795                 800 


Lys Ala Asp Tyr Met Pro Glu Thr Arg Leu Arg Ile Pro Ala Ala Glu 
                805                 810                 815     


Pro Ile Glu Tyr Ala Gln Phe Pro Phe Tyr Leu Asn Gly Leu Arg Asp 
            820                 825                 830         


Thr Ser Asp Phe Val Glu Ala Ile Glu Lys Val Arg Thr Ile Cys Ser 
        835                 840                 845             


Asn Tyr Thr Ser Leu Gly Leu Ser Ser Tyr Pro Asn Gly Tyr Pro Phe 
    850                 855                 860                 


Leu Phe Trp Glu Gln Tyr Ile Gly Leu Arg His Trp Leu Leu Leu Phe 
865                 870                 875                 880 


Ile Ser Val Val Leu Ala Cys Thr Phe Leu Val Cys Ala Val Phe Leu 
                885                 890                 895     


Leu Asn Pro Trp Thr Ala Gly Ile Ile Val Met Val Leu Ala Leu Met 
            900                 905                 910         


Thr Val Glu Leu Phe Gly Met Met Gly Leu Ile Gly Ile Lys Leu Ser 
        915                 920                 925             


Ala Val Pro Val Val Ile Leu Ile Ala Ser Val Gly Ile Gly Val Glu 
    930                 935                 940                 


Phe Thr Val His Val Ala Leu Ala Phe Leu Thr Ala Ile Gly Asp Lys 
945                 950                 955                 960 


Asn Arg Arg Ala Val Leu Ala Leu Glu His Met Phe Ala Pro Val Leu 
                965                 970                 975     


Asp Gly Ala Val Ser Thr Leu Leu Gly Val Leu Met Leu Ala Gly Ser 
            980                 985                 990         


Glu Phe Asp Phe Ile Val Arg Tyr  Phe Phe Ala Val Leu  Ala Ile Leu 
        995                 1000                 1005             


Thr Ile  Leu Gly Val Leu Asn  Gly Leu Val Leu Leu  Pro Val Leu 
    1010                 1015                 1020             


Leu Ser  Phe Phe Gly Pro Tyr  Pro Glu Val Ser Pro  Ala Asn Gly 
    1025                 1030                 1035             


Leu Asn  Arg Leu Pro Thr Pro  Ser Pro Glu Pro Pro  Pro Ser Val 
    1040                 1045                 1050             


Val Arg  Phe Ala Met Pro Pro  Gly His Thr His Ser  Gly Ser Asp 
    1055                 1060                 1065             


Ser Ser  Asp Ser Glu Tyr Ser  Ser Gln Thr Thr Val  Ser Gly Leu 
    1070                 1075                 1080             


Ser Glu  Glu Leu Arg His Tyr  Glu Ala Gln Gln Gly  Ala Gly Gly 
    1085                 1090                 1095             


Pro Ala  His Gln Val Ile Val  Glu Ala Thr Glu Asn  Pro Val Phe 
    1100                 1105                 1110             


Ala His  Ser Thr Val Val His  Pro Glu Ser Arg His  His Pro Pro 
    1115                 1120                 1125             


Ser Asn  Pro Arg Gln Gln Pro  His Leu Asp Ser Gly  Ser Leu Pro 
    1130                 1135                 1140             


Pro Gly  Arg Gln Gly Gln Gln  Pro Arg Arg Asp Pro  Pro Arg Glu 
    1145                 1150                 1155             


Gly Leu  Trp Pro Pro Pro Tyr  Arg Pro Arg Arg Asp  Ala Phe Glu 
    1160                 1165                 1170             


Ile Ser  Thr Glu Gly His Ser  Gly Pro Ser Asn Arg  Ala Arg Trp 
    1175                 1180                 1185             


Gly Pro  Arg Gly Ala Arg Ser  His Asn Pro Arg Asn  Pro Ala Ser 
    1190                 1195                 1200             


Thr Ala  Met Gly Ser Ser Val  Pro Gly Tyr Cys Gln  Pro Ile Thr 
    1205                 1210                 1215             


Thr Val  Thr Ala Ser Ala Ser  Val Thr Val Ala Val  His Pro Pro 
    1220                 1225                 1230             


Pro Val  Pro Gly Pro Gly Arg  Asn Pro Arg Gly Gly  Leu Cys Pro 
    1235                 1240                 1245             


Gly Tyr  Pro Glu Thr Asp His  Gly Leu Phe Glu Asp  Pro His Val 
    1250                 1255                 1260             


Pro Phe  His Val Arg Cys Glu  Arg Arg Asp Ser Lys  Val Glu Val 
    1265                 1270                 1275             


Ile Glu  Leu Gln Asp Val Glu  Cys Glu Glu Arg Pro  Arg Gly Ser 
    1280                 1285                 1290             


Ser Ser  Asn 
    1295     


<210> 35
<211> 770
<212> PRT
<213> Homo sapiens

<400> 35
Met Phe Pro Gln Ser Arg His Pro Thr Pro His Gln Ala Ala Gly Gln 
1               5                   10                  15      


Pro Phe Lys Phe Thr Ile Pro Glu Ser Leu Asp Arg Ile Lys Glu Glu 
            20                  25                  30          


Phe Gln Phe Leu Gln Ala Gln Tyr His Ser Leu Lys Leu Glu Cys Glu 
        35                  40                  45              


Lys Leu Ala Ser Glu Lys Thr Glu Met Gln Arg His Tyr Val Met Tyr 
    50                  55                  60                  


Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Thr Glu 
65                  70                  75                  80  


Ile Ala Lys Arg Leu Asn Thr Ile Cys Ala Gln Val Ile Pro Phe Leu 
                85                  90                  95      


Ser Gln Glu His Gln Gln Gln Val Ala Gln Ala Val Glu Arg Ala Lys 
            100                 105                 110         


Gln Val Thr Met Ala Glu Leu Asn Ala Ile Ile Gly Gln Gln Gln Leu 
        115                 120                 125             


Gln Ala Gln His Leu Ser His Gly His Gly Pro Pro Val Pro Leu Thr 
    130                 135                 140                 


Pro His Pro Ser Gly Leu Gln Pro Pro Gly Ile Pro Pro Leu Gly Gly 
145                 150                 155                 160 


Ser Ala Gly Leu Leu Ala Leu Ser Ser Ala Leu Ser Gly Gln Ser His 
                165                 170                 175     


Leu Ala Ile Lys Asp Asp Lys Lys His His Asp Ala Glu His His Arg 
            180                 185                 190         


Asp Arg Glu Pro Gly Thr Ser Asn Ser Leu Leu Val Pro Asp Ser Leu 
        195                 200                 205             


Arg Gly Thr Asp Lys Arg Arg Asn Gly Pro Glu Phe Ser Asn Asp Ile 
    210                 215                 220                 


Lys Lys Arg Lys Val Asp Asp Lys Asp Ser Ser His Tyr Asp Ser Asp 
225                 230                 235                 240 


Gly Asp Lys Ser Asp Asp Asn Leu Val Val Asp Val Ser Asn Glu Asp 
                245                 250                 255     


Pro Ser Ser Pro Arg Ala Ser Pro Ala His Ser Pro Arg Glu Asn Gly 
            260                 265                 270         


Ile Asp Lys Asn Arg Leu Leu Lys Lys Asp Ala Ser Ser Ser Pro Ala 
        275                 280                 285             


Ser Thr Ala Ser Ser Ala Ser Ser Thr Ser Leu Lys Ser Lys Glu Met 
    290                 295                 300                 


Ser Leu His Glu Lys Ala Ser Thr Pro Val Leu Lys Ser Ser Thr Pro 
305                 310                 315                 320 


Thr Pro Arg Ser Asp Met Pro Thr Pro Gly Thr Ser Ala Thr Pro Gly 
                325                 330                 335     


Leu Arg Pro Gly Leu Gly Lys Pro Pro Ala Ile Asp Pro Leu Val Asn 
            340                 345                 350         


Gln Ala Ala Ala Gly Leu Arg Thr Pro Leu Ala Val Pro Gly Pro Tyr 
        355                 360                 365             


Pro Ala Pro Phe Gly Met Val Pro His Ala Gly Met Asn Gly Glu Leu 
    370                 375                 380                 


Thr Ser Pro Gly Ala Ala Tyr Ala Ser Leu His Asn Met Ser Pro Gln 
385                 390                 395                 400 


Met Ser Ala Ala Ala Ala Ala Ala Ala Val Val Ala Tyr Gly Arg Ser 
                405                 410                 415     


Pro Met Val Gly Phe Asp Pro Pro Pro His Met Arg Val Pro Thr Ile 
            420                 425                 430         


Pro Pro Asn Leu Ala Gly Ile Pro Gly Gly Lys Pro Ala Tyr Ser Phe 
        435                 440                 445             


His Val Thr Ala Asp Gly Gln Met Gln Pro Val Pro Phe Pro Pro Asp 
    450                 455                 460                 


Ala Leu Ile Gly Pro Gly Ile Pro Arg His Ala Arg Gln Ile Asn Thr 
465                 470                 475                 480 


Leu Asn His Gly Glu Val Val Cys Ala Val Thr Ile Ser Asn Pro Thr 
                485                 490                 495     


Arg His Val Tyr Thr Gly Gly Lys Gly Cys Val Lys Val Trp Asp Ile 
            500                 505                 510         


Ser His Pro Gly Asn Lys Ser Pro Val Ser Gln Leu Asp Cys Leu Asn 
        515                 520                 525             


Arg Asp Asn Tyr Ile Arg Ser Cys Lys Leu Leu Pro Asp Gly Cys Thr 
    530                 535                 540                 


Leu Ile Val Gly Gly Glu Ala Ser Thr Leu Ser Ile Trp Asp Leu Ala 
545                 550                 555                 560 


Ala Pro Thr Pro Arg Ile Lys Ala Glu Leu Thr Ser Ser Ala Pro Ala 
                565                 570                 575     


Cys Tyr Ala Leu Ala Ile Ser Pro Asp Ser Lys Val Cys Phe Ser Cys 
            580                 585                 590         


Cys Ser Asp Gly Asn Ile Ala Val Trp Asp Leu His Asn Gln Thr Leu 
        595                 600                 605             


Val Arg Gln Phe Gln Gly His Thr Asp Gly Ala Ser Cys Ile Asp Ile 
    610                 615                 620                 


Ser Asn Asp Gly Thr Lys Leu Trp Thr Gly Gly Leu Asp Asn Thr Val 
625                 630                 635                 640 


Arg Ser Trp Asp Leu Arg Glu Gly Arg Gln Leu Gln Gln His Asp Phe 
                645                 650                 655     


Thr Ser Gln Ile Phe Ser Leu Gly Tyr Cys Pro Thr Gly Glu Trp Leu 
            660                 665                 670         


Ala Val Gly Met Glu Ser Ser Asn Val Glu Val Leu His Val Asn Lys 
        675                 680                 685             


Pro Asp Lys Tyr Gln Leu His Leu His Glu Ser Cys Val Leu Ser Leu 
    690                 695                 700                 


Lys Phe Ala Tyr Cys Gly Lys Trp Phe Val Ser Thr Gly Lys Asp Asn 
705                 710                 715                 720 


Leu Leu Asn Ala Trp Arg Thr Pro Tyr Gly Ala Ser Ile Phe Gln Ser 
                725                 730                 735     


Lys Glu Ser Ser Ser Val Leu Ser Cys Asp Ile Ser Val Asp Asp Lys 
            740                 745                 750         


Tyr Ile Val Thr Gly Ser Gly Asp Lys Lys Ala Thr Val Tyr Glu Val 
        755                 760                 765             


Ile Tyr 
    770 


<210> 36
<211> 1960
<212> PRT
<213> Homo sapiens

<400> 36
Met Ala Gln Gln Ala Ala Asp Lys Tyr Leu Tyr Val Asp Lys Asn Phe 
1               5                   10                  15      


Ile Asn Asn Pro Leu Ala Gln Ala Asp Trp Ala Ala Lys Lys Leu Val 
            20                  25                  30          


Trp Val Pro Ser Asp Lys Ser Gly Phe Glu Pro Ala Ser Leu Lys Glu 
        35                  40                  45              


Glu Val Gly Glu Glu Ala Ile Val Glu Leu Val Glu Asn Gly Lys Lys 
    50                  55                  60                  


Val Lys Val Asn Lys Asp Asp Ile Gln Lys Met Asn Pro Pro Lys Phe 
65                  70                  75                  80  


Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu Asn Glu Ala Ser 
                85                  90                  95      


Val Leu His Asn Leu Lys Glu Arg Tyr Tyr Ser Gly Leu Ile Tyr Thr 
            100                 105                 110         


Tyr Ser Gly Leu Phe Cys Val Val Ile Asn Pro Tyr Lys Asn Leu Pro 
        115                 120                 125             


Ile Tyr Ser Glu Glu Ile Val Glu Met Tyr Lys Gly Lys Lys Arg His 
    130                 135                 140                 


Glu Met Pro Pro His Ile Tyr Ala Ile Thr Asp Thr Ala Tyr Arg Ser 
145                 150                 155                 160 


Met Met Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys Thr Gly Glu Ser 
                165                 170                 175     


Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile Gln Tyr Leu Ala 
            180                 185                 190         


Tyr Val Ala Ser Ser His Lys Ser Lys Lys Asp Gln Gly Glu Leu Glu 
        195                 200                 205             


Arg Gln Leu Leu Gln Ala Asn Pro Ile Leu Glu Ala Phe Gly Asn Ala 
    210                 215                 220                 


Lys Thr Val Lys Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg 
225                 230                 235                 240 


Ile Asn Phe Asp Val Asn Gly Tyr Ile Val Gly Ala Asn Ile Glu Thr 
                245                 250                 255     


Tyr Leu Leu Glu Lys Ser Arg Ala Ile Arg Gln Ala Lys Glu Glu Arg 
            260                 265                 270         


Thr Phe His Ile Phe Tyr Tyr Leu Leu Ser Gly Ala Gly Glu His Leu 
        275                 280                 285             


Lys Thr Asp Leu Leu Leu Glu Pro Tyr Asn Lys Tyr Arg Phe Leu Ser 
    290                 295                 300                 


Asn Gly His Val Thr Ile Pro Gly Gln Gln Asp Lys Asp Met Phe Gln 
305                 310                 315                 320 


Glu Thr Met Glu Ala Met Arg Ile Met Gly Ile Pro Glu Glu Glu Gln 
                325                 330                 335     


Met Gly Leu Leu Arg Val Ile Ser Gly Val Leu Gln Leu Gly Asn Ile 
            340                 345                 350         


Val Phe Lys Lys Glu Arg Asn Thr Asp Gln Ala Ser Met Pro Asp Asn 
        355                 360                 365             


Thr Ala Ala Gln Lys Val Ser His Leu Leu Gly Ile Asn Val Thr Asp 
    370                 375                 380                 


Phe Thr Arg Gly Ile Leu Thr Pro Arg Ile Lys Val Gly Arg Asp Tyr 
385                 390                 395                 400 


Val Gln Lys Ala Gln Thr Lys Glu Gln Ala Asp Phe Ala Ile Glu Ala 
                405                 410                 415     


Leu Ala Lys Ala Thr Tyr Glu Arg Met Phe Arg Trp Leu Val Leu Arg 
            420                 425                 430         


Ile Asn Lys Ala Leu Asp Lys Thr Lys Arg Gln Gly Ala Ser Phe Ile 
        435                 440                 445             


Gly Ile Leu Asp Ile Ala Gly Phe Glu Ile Phe Asp Leu Asn Ser Phe 
    450                 455                 460                 


Glu Gln Leu Cys Ile Asn Tyr Thr Asn Glu Lys Leu Gln Gln Leu Phe 
465                 470                 475                 480 


Asn His Thr Met Phe Ile Leu Glu Gln Glu Glu Tyr Gln Arg Glu Gly 
                485                 490                 495     


Ile Glu Trp Asn Phe Ile Asp Phe Gly Leu Asp Leu Gln Pro Cys Ile 
            500                 505                 510         


Asp Leu Ile Glu Lys Pro Ala Gly Pro Pro Gly Ile Leu Ala Leu Leu 
        515                 520                 525             


Asp Glu Glu Cys Trp Phe Pro Lys Ala Thr Asp Lys Ser Phe Val Glu 
    530                 535                 540                 


Lys Val Met Gln Glu Gln Gly Thr His Pro Lys Phe Gln Lys Pro Lys 
545                 550                 555                 560 


Gln Leu Lys Asp Lys Ala Asp Phe Cys Ile Ile His Tyr Ala Gly Lys 
                565                 570                 575     


Val Asp Tyr Lys Ala Asp Glu Trp Leu Met Lys Asn Met Asp Pro Leu 
            580                 585                 590         


Asn Asp Asn Ile Ala Thr Leu Leu His Gln Ser Ser Asp Lys Phe Val 
        595                 600                 605             


Ser Glu Leu Trp Lys Asp Val Asp Arg Ile Ile Gly Leu Asp Gln Val 
    610                 615                 620                 


Ala Gly Met Ser Glu Thr Ala Leu Pro Gly Ala Phe Lys Thr Arg Lys 
625                 630                 635                 640 


Gly Met Phe Arg Thr Val Gly Gln Leu Tyr Lys Glu Gln Leu Ala Lys 
                645                 650                 655     


Leu Met Ala Thr Leu Arg Asn Thr Asn Pro Asn Phe Val Arg Cys Ile 
            660                 665                 670         


Ile Pro Asn His Glu Lys Lys Ala Gly Lys Leu Asp Pro His Leu Val 
        675                 680                 685             


Leu Asp Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg Ile Cys 
    690                 695                 700                 


Arg Gln Gly Phe Pro Asn Arg Val Val Phe Gln Glu Phe Arg Gln Arg 
705                 710                 715                 720 


Tyr Glu Ile Leu Thr Pro Asn Ser Ile Pro Lys Gly Phe Met Asp Gly 
                725                 730                 735     


Lys Gln Ala Cys Val Leu Met Ile Lys Ala Leu Glu Leu Asp Ser Asn 
            740                 745                 750         


Leu Tyr Arg Ile Gly Gln Ser Lys Val Phe Phe Arg Ala Gly Val Leu 
        755                 760                 765             


Ala His Leu Glu Glu Glu Arg Asp Leu Lys Ile Thr Asp Val Ile Ile 
    770                 775                 780                 


Gly Phe Gln Ala Cys Cys Arg Gly Tyr Leu Ala Arg Lys Ala Phe Ala 
785                 790                 795                 800 


Lys Arg Gln Gln Gln Leu Thr Ala Met Lys Val Leu Gln Arg Asn Cys 
                805                 810                 815     


Ala Ala Tyr Leu Lys Leu Arg Asn Trp Gln Trp Trp Arg Leu Phe Thr 
            820                 825                 830         


Lys Val Lys Pro Leu Leu Gln Val Ser Arg Gln Glu Glu Glu Met Met 
        835                 840                 845             


Ala Lys Glu Glu Glu Leu Val Lys Val Arg Glu Lys Gln Leu Ala Ala 
    850                 855                 860                 


Glu Asn Arg Leu Thr Glu Met Glu Thr Leu Gln Ser Gln Leu Met Ala 
865                 870                 875                 880 


Glu Lys Leu Gln Leu Gln Glu Gln Leu Gln Ala Glu Thr Glu Leu Cys 
                885                 890                 895     


Ala Glu Ala Glu Glu Leu Arg Ala Arg Leu Thr Ala Lys Lys Gln Glu 
            900                 905                 910         


Leu Glu Glu Ile Cys His Asp Leu Glu Ala Arg Val Glu Glu Glu Glu 
        915                 920                 925             


Glu Arg Cys Gln His Leu Gln Ala Glu Lys Lys Lys Met Gln Gln Asn 
    930                 935                 940                 


Ile Gln Glu Leu Glu Glu Gln Leu Glu Glu Glu Glu Ser Ala Arg Gln 
945                 950                 955                 960 


Lys Leu Gln Leu Glu Lys Val Thr Thr Glu Ala Lys Leu Lys Lys Leu 
                965                 970                 975     


Glu Glu Glu Gln Ile Ile Leu Glu Asp Gln Asn Cys Lys Leu Ala Lys 
            980                 985                 990         


Glu Lys Lys Leu Leu Glu Asp Arg  Ile Ala Glu Phe Thr  Thr Asn Leu 
        995                 1000                 1005             


Thr Glu  Glu Glu Glu Lys Ser  Lys Ser Leu Ala Lys  Leu Lys Asn 
    1010                 1015                 1020             


Lys His  Glu Ala Met Ile Thr  Asp Leu Glu Glu Arg  Leu Arg Arg 
    1025                 1030                 1035             


Glu Glu  Lys Gln Arg Gln Glu  Leu Glu Lys Thr Arg  Arg Lys Leu 
    1040                 1045                 1050             


Glu Gly  Asp Ser Thr Asp Leu  Ser Asp Gln Ile Ala  Glu Leu Gln 
    1055                 1060                 1065             


Ala Gln  Ile Ala Glu Leu Lys  Met Gln Leu Ala Lys  Lys Glu Glu 
    1070                 1075                 1080             


Glu Leu  Gln Ala Ala Leu Ala  Arg Val Glu Glu Glu  Ala Ala Gln 
    1085                 1090                 1095             


Lys Asn  Met Ala Leu Lys Lys  Ile Arg Glu Leu Glu  Ser Gln Ile 
    1100                 1105                 1110             


Ser Glu  Leu Gln Glu Asp Leu  Glu Ser Glu Arg Ala  Ser Arg Asn 
    1115                 1120                 1125             


Lys Ala  Glu Lys Gln Lys Arg  Asp Leu Gly Glu Glu  Leu Glu Ala 
    1130                 1135                 1140             


Leu Lys  Thr Glu Leu Glu Asp  Thr Leu Asp Ser Thr  Ala Ala Gln 
    1145                 1150                 1155             


Gln Glu  Leu Arg Ser Lys Arg  Glu Gln Glu Val Asn  Ile Leu Lys 
    1160                 1165                 1170             


Lys Thr  Leu Glu Glu Glu Ala  Lys Thr His Glu Ala  Gln Ile Gln 
    1175                 1180                 1185             


Glu Met  Arg Gln Lys His Ser  Gln Ala Val Glu Glu  Leu Ala Glu 
    1190                 1195                 1200             


Gln Leu  Glu Gln Thr Lys Arg  Val Lys Ala Asn Leu  Glu Lys Ala 
    1205                 1210                 1215             


Lys Gln  Thr Leu Glu Asn Glu  Arg Gly Glu Leu Ala  Asn Glu Val 
    1220                 1225                 1230             


Lys Val  Leu Leu Gln Gly Lys  Gly Asp Ser Glu His  Lys Arg Lys 
    1235                 1240                 1245             


Lys Val  Glu Ala Gln Leu Gln  Glu Leu Gln Val Lys  Phe Asn Glu 
    1250                 1255                 1260             


Gly Glu  Arg Val Arg Thr Glu  Leu Ala Asp Lys Val  Thr Lys Leu 
    1265                 1270                 1275             


Gln Val  Glu Leu Asp Asn Val  Thr Gly Leu Leu Ser  Gln Ser Asp 
    1280                 1285                 1290             


Ser Lys  Ser Ser Lys Leu Thr  Lys Asp Phe Ser Ala  Leu Glu Ser 
    1295                 1300                 1305             


Gln Leu  Gln Asp Thr Gln Glu  Leu Leu Gln Glu Glu  Asn Arg Gln 
    1310                 1315                 1320             


Lys Leu  Ser Leu Ser Thr Lys  Leu Lys Gln Val Glu  Asp Glu Lys 
    1325                 1330                 1335             


Asn Ser  Phe Arg Glu Gln Leu  Glu Glu Glu Glu Glu  Ala Lys His 
    1340                 1345                 1350             


Asn Leu  Glu Lys Gln Ile Ala  Thr Leu His Ala Gln  Val Ala Asp 
    1355                 1360                 1365             


Met Lys  Lys Lys Met Glu Asp  Ser Val Gly Cys Leu  Glu Thr Ala 
    1370                 1375                 1380             


Glu Glu  Val Lys Arg Lys Leu  Gln Lys Asp Leu Glu  Gly Leu Ser 
    1385                 1390                 1395             


Gln Arg  His Glu Glu Lys Val  Ala Ala Tyr Asp Lys  Leu Glu Lys 
    1400                 1405                 1410             


Thr Lys  Thr Arg Leu Gln Gln  Glu Leu Asp Asp Leu  Leu Val Asp 
    1415                 1420                 1425             


Leu Asp  His Gln Arg Gln Ser  Ala Cys Asn Leu Glu  Lys Lys Gln 
    1430                 1435                 1440             


Lys Lys  Phe Asp Gln Leu Leu  Ala Glu Glu Lys Thr  Ile Ser Ala 
    1445                 1450                 1455             


Lys Tyr  Ala Glu Glu Arg Asp  Arg Ala Glu Ala Glu  Ala Arg Glu 
    1460                 1465                 1470             


Lys Glu  Thr Lys Ala Leu Ser  Leu Ala Arg Ala Leu  Glu Glu Ala 
    1475                 1480                 1485             


Met Glu  Gln Lys Ala Glu Leu  Glu Arg Leu Asn Lys  Gln Phe Arg 
    1490                 1495                 1500             


Thr Glu  Met Glu Asp Leu Met  Ser Ser Lys Asp Asp  Val Gly Lys 
    1505                 1510                 1515             


Ser Val  His Glu Leu Glu Lys  Ser Lys Arg Ala Leu  Glu Gln Gln 
    1520                 1525                 1530             


Val Glu  Glu Met Lys Thr Gln  Leu Glu Glu Leu Glu  Asp Glu Leu 
    1535                 1540                 1545             


Gln Ala  Thr Glu Asp Ala Lys  Leu Arg Leu Glu Val  Asn Leu Gln 
    1550                 1555                 1560             


Ala Met  Lys Ala Gln Phe Glu  Arg Asp Leu Gln Gly  Arg Asp Glu 
    1565                 1570                 1575             


Gln Ser  Glu Glu Lys Lys Lys  Gln Leu Val Arg Gln  Val Arg Glu 
    1580                 1585                 1590             


Met Glu  Ala Glu Leu Glu Asp  Glu Arg Lys Gln Arg  Ser Met Ala 
    1595                 1600                 1605             


Val Ala  Ala Arg Lys Lys Leu  Glu Met Asp Leu Lys  Asp Leu Glu 
    1610                 1615                 1620             


Ala His  Ile Asp Ser Ala Asn  Lys Asn Arg Asp Glu  Ala Ile Lys 
    1625                 1630                 1635             


Gln Leu  Arg Lys Leu Gln Ala  Gln Met Lys Asp Cys  Met Arg Glu 
    1640                 1645                 1650             


Leu Asp  Asp Thr Arg Ala Ser  Arg Glu Glu Ile Leu  Ala Gln Ala 
    1655                 1660                 1665             


Lys Glu  Asn Glu Lys Lys Leu  Lys Ser Met Glu Ala  Glu Met Ile 
    1670                 1675                 1680             


Gln Leu  Gln Glu Glu Leu Ala  Ala Ala Glu Arg Ala  Lys Arg Gln 
    1685                 1690                 1695             


Ala Gln  Gln Glu Arg Asp Glu  Leu Ala Asp Glu Ile  Ala Asn Ser 
    1700                 1705                 1710             


Ser Gly  Lys Gly Ala Leu Ala  Leu Glu Glu Lys Arg  Arg Leu Glu 
    1715                 1720                 1725             


Ala Arg  Ile Ala Gln Leu Glu  Glu Glu Leu Glu Glu  Glu Gln Gly 
    1730                 1735                 1740             


Asn Thr  Glu Leu Ile Asn Asp  Arg Leu Lys Lys Ala  Asn Leu Gln 
    1745                 1750                 1755             


Ile Asp  Gln Ile Asn Thr Asp  Leu Asn Leu Glu Arg  Ser His Ala 
    1760                 1765                 1770             


Gln Lys  Asn Glu Asn Ala Arg  Gln Gln Leu Glu Arg  Gln Asn Lys 
    1775                 1780                 1785             


Glu Leu  Lys Val Lys Leu Gln  Glu Met Glu Gly Thr  Val Lys Ser 
    1790                 1795                 1800             


Lys Tyr  Lys Ala Ser Ile Thr  Ala Leu Glu Ala Lys  Ile Ala Gln 
    1805                 1810                 1815             


Leu Glu  Glu Gln Leu Asp Asn  Glu Thr Lys Glu Arg  Gln Ala Ala 
    1820                 1825                 1830             


Cys Lys  Gln Val Arg Arg Thr  Glu Lys Lys Leu Lys  Asp Val Leu 
    1835                 1840                 1845             


Leu Gln  Val Asp Asp Glu Arg  Arg Asn Ala Glu Gln  Tyr Lys Asp 
    1850                 1855                 1860             


Gln Ala  Asp Lys Ala Ser Thr  Arg Leu Lys Gln Leu  Lys Arg Gln 
    1865                 1870                 1875             


Leu Glu  Glu Ala Glu Glu Glu  Ala Gln Arg Ala Asn  Ala Ser Arg 
    1880                 1885                 1890             


Arg Lys  Leu Gln Arg Glu Leu  Glu Asp Ala Thr Glu  Thr Ala Asp 
    1895                 1900                 1905             


Ala Met  Asn Arg Glu Val Ser  Ser Leu Lys Asn Lys  Leu Arg Arg 
    1910                 1915                 1920             


Gly Asp  Leu Pro Phe Val Val  Pro Arg Arg Met Ala  Arg Lys Gly 
    1925                 1930                 1935             


Ala Gly  Asp Gly Ser Asp Glu  Glu Val Asp Gly Lys  Ala Asp Gly 
    1940                 1945                 1950             


Ala Glu  Ala Lys Pro Ala Glu  
    1955                 1960 


<210> 37
<211> 1382
<212> PRT
<213> Homo sapiens

<400> 37
Met Tyr Lys Gly Lys Lys Arg His Glu Met Pro Pro His Ile Tyr Ala 
1               5                   10                  15      


Ile Thr Asp Thr Ala Tyr Arg Ser Met Met Gln Asp Arg Glu Asp Gln 
            20                  25                  30          


Ser Ile Leu Cys Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr 
        35                  40                  45              


Lys Lys Val Ile Gln Tyr Leu Ala Tyr Val Ala Ser Ser His Lys Ser 
    50                  55                  60                  


Lys Lys Asp Gln Gly Glu Leu Glu Arg Gln Leu Leu Gln Ala Asn Pro 
65                  70                  75                  80  


Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Lys Asn Asp Asn Ser 
                85                  90                  95      


Ser Arg Phe Gly Lys Phe Ile Arg Ile Asn Phe Asp Val Asn Gly Tyr 
            100                 105                 110         


Ile Val Gly Ala Asn Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg Ala 
        115                 120                 125             


Ile Arg Gln Ala Lys Glu Glu Arg Thr Phe His Ile Phe Tyr Tyr Leu 
    130                 135                 140                 


Leu Ser Gly Ala Gly Glu His Leu Lys Thr Asp Leu Leu Leu Glu Pro 
145                 150                 155                 160 


Tyr Asn Lys Tyr Arg Phe Leu Ser Asn Gly His Val Thr Ile Pro Gly 
                165                 170                 175     


Gln Gln Asp Lys Asp Met Phe Gln Glu Thr Met Glu Ala Met Arg Ile 
            180                 185                 190         


Met Gly Ile Pro Glu Glu Glu Gln Met Gly Leu Leu Arg Val Ile Ser 
        195                 200                 205             


Gly Val Leu Gln Leu Gly Asn Ile Val Phe Lys Lys Glu Arg Asn Thr 
    210                 215                 220                 


Asp Gln Ala Ser Met Pro Asp Asn Thr Ala Ala Gln Lys Val Ser His 
225                 230                 235                 240 


Leu Leu Gly Ile Asn Val Thr Asp Phe Thr Arg Gly Ile Leu Thr Pro 
                245                 250                 255     


Arg Ile Lys Val Gly Arg Asp Tyr Val Gln Lys Ala Gln Thr Lys Glu 
            260                 265                 270         


Gln Ala Asp Phe Ala Ile Glu Ala Leu Ala Lys Ala Thr Tyr Glu Arg 
        275                 280                 285             


Met Phe Arg Trp Leu Val Leu Arg Ile Asn Lys Ala Leu Asp Lys Thr 
    290                 295                 300                 


Lys Arg Gln Gly Ala Ser Phe Ile Gly Ile Leu Asp Ile Ala Gly Phe 
305                 310                 315                 320 


Glu Ile Phe Asp Leu Asn Ser Phe Glu Gln Leu Cys Ile Asn Tyr Thr 
                325                 330                 335     


Asn Glu Lys Leu Gln Gln Leu Phe Asn His Thr Met Phe Ile Leu Glu 
            340                 345                 350         


Gln Glu Glu Tyr Gln Arg Glu Gly Ile Glu Trp Asn Phe Ile Asp Phe 
        355                 360                 365             


Gly Leu Asp Leu Gln Pro Cys Ile Asp Leu Ile Glu Lys Pro Ala Gly 
    370                 375                 380                 


Pro Pro Gly Ile Leu Ala Leu Leu Asp Glu Glu Cys Trp Phe Pro Lys 
385                 390                 395                 400 


Ala Thr Asp Lys Ser Phe Val Glu Lys Val Met Gln Glu Gln Gly Thr 
                405                 410                 415     


His Pro Lys Phe Gln Lys Pro Lys Gln Leu Lys Asp Lys Ala Asp Phe 
            420                 425                 430         


Cys Ile Ile His Tyr Ala Gly Lys Val Asp Tyr Lys Ala Asp Glu Trp 
        435                 440                 445             


Leu Met Lys Asn Met Asp Pro Leu Asn Asp Asn Ile Ala Thr Leu Leu 
    450                 455                 460                 


His Gln Ser Ser Asp Lys Phe Val Ser Glu Leu Trp Lys Asp Val Asp 
465                 470                 475                 480 


Arg Ile Ile Gly Leu Asp Gln Val Ala Gly Met Ser Glu Thr Ala Leu 
                485                 490                 495     


Pro Gly Ala Phe Lys Thr Arg Lys Gly Met Phe Arg Thr Val Gly Gln 
            500                 505                 510         


Leu Tyr Lys Glu Gln Leu Ala Lys Leu Met Ala Thr Leu Arg Asn Thr 
        515                 520                 525             


Asn Pro Asn Phe Val Arg Cys Ile Ile Pro Asn His Glu Lys Lys Ala 
    530                 535                 540                 


Gly Lys Leu Asp Pro His Leu Val Leu Asp Gln Leu Arg Cys Asn Gly 
545                 550                 555                 560 


Val Leu Glu Gly Ile Arg Ile Cys Arg Gln Gly Phe Pro Asn Arg Val 
                565                 570                 575     


Val Phe Gln Glu Phe Arg Gln Arg Tyr Glu Ile Leu Thr Pro Asn Ser 
            580                 585                 590         


Ile Pro Lys Gly Phe Met Asp Gly Lys Gln Ala Cys Val Leu Met Ile 
        595                 600                 605             


Lys Ala Leu Glu Leu Asp Ser Asn Leu Tyr Arg Ile Gly Gln Ser Lys 
    610                 615                 620                 


Val Phe Phe Arg Ala Gly Val Leu Ala His Leu Glu Glu Glu Arg Asp 
625                 630                 635                 640 


Leu Lys Ile Thr Asp Val Ile Ile Gly Phe Gln Ala Cys Cys Arg Gly 
                645                 650                 655     


Tyr Leu Ala Arg Lys Ala Phe Ala Lys Arg Gln Gln Gln Leu Thr Ala 
            660                 665                 670         


Met Lys Val Leu Gln Arg Asn Cys Ala Ala Tyr Leu Lys Leu Arg Asn 
        675                 680                 685             


Trp Gln Trp Trp Arg Leu Phe Thr Lys Val Lys Pro Leu Leu Gln Val 
    690                 695                 700                 


Ser Arg Gln Glu Glu Glu Met Met Ala Lys Glu Glu Glu Leu Val Lys 
705                 710                 715                 720 


Val Arg Glu Lys Gln Leu Ala Ala Glu Asn Arg Leu Thr Glu Met Glu 
                725                 730                 735     


Thr Leu Gln Ser Gln Leu Met Ala Glu Lys Leu Gln Leu Gln Glu Gln 
            740                 745                 750         


Leu Gln Ala Glu Thr Glu Leu Cys Ala Glu Ala Glu Glu Leu Arg Ala 
        755                 760                 765             


Arg Leu Thr Ala Lys Lys Gln Glu Leu Glu Glu Ile Cys His Asp Leu 
    770                 775                 780                 


Glu Ala Arg Val Glu Glu Glu Glu Glu Arg Cys Gln His Leu Gln Ala 
785                 790                 795                 800 


Glu Lys Lys Lys Met Gln Gln Asn Ile Gln Glu Leu Glu Glu Gln Leu 
                805                 810                 815     


Glu Glu Glu Glu Ser Ala Arg Gln Lys Leu Gln Leu Glu Lys Val Thr 
            820                 825                 830         


Thr Glu Ala Lys Leu Lys Lys Leu Glu Glu Glu Leu Asp Asp Leu Leu 
        835                 840                 845             


Val Asp Leu Asp His Gln Arg Gln Ser Ala Cys Asn Leu Glu Lys Lys 
    850                 855                 860                 


Gln Lys Lys Phe Asp Gln Leu Leu Ala Glu Glu Lys Thr Ile Ser Ala 
865                 870                 875                 880 


Lys Tyr Ala Glu Glu Arg Asp Arg Ala Glu Ala Glu Ala Arg Glu Lys 
                885                 890                 895     


Glu Thr Lys Ala Leu Ser Leu Ala Arg Ala Leu Glu Glu Ala Met Glu 
            900                 905                 910         


Gln Lys Ala Glu Leu Glu Arg Leu Asn Lys Gln Phe Arg Thr Glu Met 
        915                 920                 925             


Glu Asp Leu Met Ser Ser Lys Asp Asp Val Gly Lys Ser Val His Glu 
    930                 935                 940                 


Leu Glu Lys Ser Lys Arg Ala Leu Glu Gln Gln Val Glu Glu Met Lys 
945                 950                 955                 960 


Thr Gln Leu Glu Glu Leu Glu Asp Glu Leu Gln Ala Thr Glu Asp Ala 
                965                 970                 975     


Lys Leu Arg Leu Glu Val Asn Leu Gln Ala Met Lys Ala Gln Phe Glu 
            980                 985                 990         


Arg Asp Leu Gln Gly Arg Asp Glu  Gln Ser Glu Glu Lys  Lys Lys Gln 
        995                 1000                 1005             


Leu Val  Arg Gln Val Arg Glu  Met Glu Ala Glu Leu  Glu Asp Glu 
    1010                 1015                 1020             


Arg Lys  Gln Arg Ser Met Ala  Val Ala Ala Arg Lys  Lys Leu Glu 
    1025                 1030                 1035             


Met Asp  Leu Lys Asp Leu Glu  Ala His Ile Asp Ser  Ala Asn Lys 
    1040                 1045                 1050             


Asn Arg  Asp Glu Ala Ile Lys  Gln Leu Arg Lys Leu  Gln Ala Gln 
    1055                 1060                 1065             


Met Lys  Asp Cys Met Arg Glu  Leu Asp Asp Thr Arg  Ala Ser Arg 
    1070                 1075                 1080             


Glu Glu  Ile Leu Ala Gln Ala  Lys Glu Asn Glu Lys  Lys Leu Lys 
    1085                 1090                 1095             


Ser Met  Glu Ala Glu Met Ile  Gln Leu Gln Glu Glu  Leu Ala Ala 
    1100                 1105                 1110             


Ala Glu  Arg Ala Lys Arg Gln  Ala Gln Gln Glu Arg  Asp Glu Leu 
    1115                 1120                 1125             


Ala Asp  Glu Ile Ala Asn Ser  Ser Gly Lys Gly Ala  Leu Ala Leu 
    1130                 1135                 1140             


Glu Glu  Lys Arg Arg Leu Glu  Ala Arg Ile Ala Gln  Leu Glu Glu 
    1145                 1150                 1155             


Glu Leu  Glu Glu Glu Gln Gly  Asn Thr Glu Leu Ile  Asn Asp Arg 
    1160                 1165                 1170             


Leu Lys  Lys Ala Asn Leu Gln  Ile Asp Gln Ile Asn  Thr Asp Leu 
    1175                 1180                 1185             


Asn Leu  Glu Arg Ser His Ala  Gln Lys Asn Glu Asn  Ala Arg Gln 
    1190                 1195                 1200             


Gln Leu  Glu Arg Gln Asn Lys  Glu Leu Lys Val Lys  Leu Gln Glu 
    1205                 1210                 1215             


Met Glu  Gly Thr Val Lys Ser  Lys Tyr Lys Ala Ser  Ile Thr Ala 
    1220                 1225                 1230             


Leu Glu  Ala Lys Ile Ala Gln  Leu Glu Glu Gln Leu  Asp Asn Glu 
    1235                 1240                 1245             


Thr Lys  Glu Arg Gln Ala Ala  Cys Lys Gln Val Arg  Arg Thr Glu 
    1250                 1255                 1260             


Lys Lys  Leu Lys Asp Val Leu  Leu Gln Val Asp Asp  Glu Arg Arg 
    1265                 1270                 1275             


Asn Ala  Glu Gln Tyr Lys Asp  Gln Ala Asp Lys Ala  Ser Thr Arg 
    1280                 1285                 1290             


Leu Lys  Gln Leu Lys Arg Gln  Leu Glu Glu Ala Glu  Glu Glu Ala 
    1295                 1300                 1305             


Gln Arg  Ala Asn Ala Ser Arg  Arg Lys Leu Gln Arg  Glu Leu Glu 
    1310                 1315                 1320             


Asp Ala  Thr Glu Thr Ala Asp  Ala Met Asn Arg Glu  Val Ser Ser 
    1325                 1330                 1335             


Leu Lys  Asn Lys Leu Arg Arg  Gly Asp Leu Pro Phe  Val Val Pro 
    1340                 1345                 1350             


Arg Arg  Met Ala Arg Lys Gly  Ala Gly Asp Gly Ser  Asp Glu Glu 
    1355                 1360                 1365             


Val Asp  Gly Lys Ala Asp Gly  Ala Glu Ala Lys Pro  Ala Glu 
    1370                 1375                 1380         


<210> 38
<211> 1047
<212> PRT
<213> Homo sapiens

<400> 38
Met Met Ala Ala Glu Ala Gly Ser Glu Glu Gly Gly Pro Val Thr Ala 
1               5                   10                  15      


Gly Ala Gly Gly Gly Gly Ala Ala Ala Gly Ser Ser Ala Tyr Pro Ala 
            20                  25                  30          


Val Cys Arg Val Lys Ile Pro Ala Ala Leu Pro Val Ala Ala Ala Pro 
        35                  40                  45              


Tyr Pro Gly Leu Val Glu Thr Gly Val Ala Gly Thr Leu Gly Gly Gly 
    50                  55                  60                  


Ala Ala Leu Gly Ser Glu Phe Leu Gly Ala Gly Ser Val Ala Gly Ala 
65                  70                  75                  80  


Leu Gly Gly Ala Gly Leu Thr Gly Gly Gly Thr Ala Ala Gly Val Ala 
                85                  90                  95      


Gly Ala Ala Ala Gly Val Ala Gly Ala Ala Val Ala Gly Pro Ser Gly 
            100                 105                 110         


Asp Met Ala Leu Thr Lys Leu Pro Thr Ser Leu Leu Ala Glu Thr Leu 
        115                 120                 125             


Gly Pro Gly Gly Gly Phe Pro Pro Leu Pro Pro Pro Pro Tyr Leu Pro 
    130                 135                 140                 


Pro Leu Gly Ala Gly Leu Gly Thr Val Asp Glu Gly Asp Ser Leu Asp 
145                 150                 155                 160 


Gly Pro Glu Tyr Glu Glu Glu Glu Val Ala Ile Pro Leu Thr Ala Pro 
                165                 170                 175     


Pro Thr Asn Gln Trp Tyr His Gly Lys Leu Asp Arg Thr Ile Ala Glu 
            180                 185                 190         


Glu Arg Leu Arg Gln Ala Gly Lys Ser Gly Ser Tyr Leu Ile Arg Glu 
        195                 200                 205             


Ser Asp Arg Arg Pro Gly Ser Phe Val Leu Ser Phe Leu Ser Gln Met 
    210                 215                 220                 


Asn Val Val Asn His Phe Arg Ile Ile Ala Met Cys Gly Asp Tyr Tyr 
225                 230                 235                 240 


Ile Gly Gly Arg Arg Phe Ser Ser Leu Ser Asp Leu Ile Gly Tyr Tyr 
                245                 250                 255     


Ser His Val Ser Cys Leu Leu Lys Gly Glu Lys Leu Leu Tyr Pro Val 
            260                 265                 270         


Ala Pro Pro Glu Pro Val Glu Asp Arg Arg Arg Val Arg Ala Ile Leu 
        275                 280                 285             


Pro Tyr Thr Lys Val Pro Asp Thr Asp Glu Ile Ser Phe Leu Lys Gly 
    290                 295                 300                 


Asp Met Phe Ile Val His Asn Glu Leu Glu Asp Gly Trp Met Trp Val 
305                 310                 315                 320 


Thr Asn Leu Arg Thr Asp Glu Gln Gly Leu Ile Val Glu Asp Leu Val 
                325                 330                 335     


Glu Glu Val Gly Arg Glu Glu Asp Pro His Glu Gly Lys Ile Trp Phe 
            340                 345                 350         


His Gly Lys Ile Ser Lys Gln Glu Ala Tyr Asn Leu Leu Met Thr Val 
        355                 360                 365             


Gly Gln Val Cys Ser Phe Leu Val Arg Pro Ser Asp Asn Thr Pro Gly 
    370                 375                 380                 


Asp Tyr Ser Leu Tyr Phe Arg Thr Asn Glu Asn Ile Gln Arg Phe Lys 
385                 390                 395                 400 


Ile Cys Pro Thr Pro Asn Asn Gln Phe Met Met Gly Gly Arg Tyr Tyr 
                405                 410                 415     


Asn Ser Ile Gly Asp Ile Ile Asp His Tyr Arg Lys Glu Gln Ile Val 
            420                 425                 430         


Glu Gly Tyr Tyr Leu Lys Glu Pro Val Pro Met Gln Asp Gln Glu Gln 
        435                 440                 445             


Val Leu Asn Asp Thr Val Asp Gly Lys Glu Ile Tyr Asn Thr Ile Arg 
    450                 455                 460                 


Arg Lys Thr Lys Asp Ala Phe Tyr Lys Asn Ile Val Lys Lys Gly Tyr 
465                 470                 475                 480 


Leu Leu Lys Lys Gly Lys Gly Lys Arg Trp Lys Asn Leu Tyr Phe Ile 
                485                 490                 495     


Leu Glu Gly Ser Asp Ala Gln Leu Ile Tyr Phe Glu Ser Glu Lys Arg 
            500                 505                 510         


Ala Thr Lys Pro Lys Gly Leu Ile Asp Leu Ser Val Cys Ser Val Tyr 
        515                 520                 525             


Val Val His Asp Ser Leu Phe Gly Arg Pro Asn Cys Phe Gln Ile Val 
    530                 535                 540                 


Val Gln His Phe Ser Glu Glu His Tyr Ile Phe Tyr Phe Ala Gly Glu 
545                 550                 555                 560 


Thr Pro Glu Gln Ala Glu Asp Trp Met Lys Gly Leu Gln Ala Phe Cys 
                565                 570                 575     


Asn Leu Arg Lys Ser Ser Pro Gly Thr Ser Asn Lys Arg Leu Arg Gln 
            580                 585                 590         


Val Ser Ser Leu Val Leu His Ile Glu Glu Ala His Lys Leu Pro Val 
        595                 600                 605             


Lys His Phe Thr Asn Pro Tyr Cys Asn Ile Tyr Leu Asn Ser Val Gln 
    610                 615                 620                 


Val Ala Lys Thr His Ala Arg Glu Gly Gln Asn Pro Val Trp Ser Glu 
625                 630                 635                 640 


Glu Phe Val Phe Asp Asp Leu Pro Pro Asp Ile Asn Arg Phe Glu Ile 
                645                 650                 655     


Thr Leu Ser Asn Lys Thr Lys Lys Ser Lys Asp Pro Asp Ile Leu Phe 
            660                 665                 670         


Met Arg Cys Gln Leu Ser Arg Leu Gln Lys Gly His Ala Thr Asp Glu 
        675                 680                 685             


Trp Phe Leu Leu Ser Ser His Ile Pro Leu Lys Gly Ile Glu Pro Gly 
    690                 695                 700                 


Ser Leu Arg Val Arg Ala Arg Tyr Ser Met Glu Lys Ile Met Pro Glu 
705                 710                 715                 720 


Glu Glu Tyr Ser Glu Phe Lys Glu Leu Ile Leu Gln Lys Glu Leu His 
                725                 730                 735     


Val Val Tyr Ala Leu Ser His Val Cys Gly Gln Asp Arg Thr Leu Leu 
            740                 745                 750         


Ala Ser Ile Leu Leu Arg Ile Phe Leu His Glu Lys Leu Glu Ser Leu 
        755                 760                 765             


Leu Leu Cys Thr Leu Asn Asp Arg Glu Ile Ser Met Glu Asp Glu Ala 
    770                 775                 780                 


Thr Thr Leu Phe Arg Ala Thr Thr Leu Ala Ser Thr Leu Met Glu Gln 
785                 790                 795                 800 


Tyr Met Lys Ala Thr Ala Thr Gln Phe Val His His Ala Leu Lys Asp 
                805                 810                 815     


Ser Ile Leu Lys Ile Met Glu Ser Lys Gln Ser Cys Glu Leu Ser Pro 
            820                 825                 830         


Ser Lys Leu Glu Lys Asn Glu Asp Val Asn Thr Asn Leu Thr His Leu 
        835                 840                 845             


Leu Asn Ile Leu Ser Glu Leu Val Glu Lys Ile Phe Met Ala Ser Glu 
    850                 855                 860                 


Ile Leu Pro Pro Thr Leu Arg Tyr Ile Tyr Gly Cys Leu Gln Lys Ser 
865                 870                 875                 880 


Val Gln His Lys Trp Pro Thr Asn Thr Thr Met Arg Thr Arg Val Val 
                885                 890                 895     


Ser Gly Phe Val Phe Leu Arg Leu Ile Cys Pro Ala Ile Leu Asn Pro 
            900                 905                 910         


Arg Met Phe Asn Ile Ile Ser Asp Ser Pro Ser Pro Ile Ala Ala Arg 
        915                 920                 925             


Thr Leu Ile Leu Val Ala Lys Ser Val Gln Asn Leu Ala Asn Leu Val 
    930                 935                 940                 


Glu Phe Gly Ala Lys Glu Pro Tyr Met Glu Gly Val Asn Pro Phe Ile 
945                 950                 955                 960 


Lys Ser Asn Lys His Arg Met Ile Met Phe Leu Asp Glu Leu Gly Asn 
                965                 970                 975     


Val Pro Glu Leu Pro Asp Thr Thr Glu His Ser Arg Thr Asp Leu Ser 
            980                 985                 990         


Arg Asp Leu Ala Ala Leu His Glu  Ile Cys Val Ala His  Ser Asp Glu 
        995                 1000                 1005             


Leu Arg  Thr Leu Ser Asn Glu  Arg Gly Ala Gln Gln  His Val Leu 
    1010                 1015                 1020             


Lys Lys  Leu Leu Ala Ile Thr  Glu Leu Leu Gln Gln  Lys Gln Asn 
    1025                 1030                 1035             


Gln Tyr  Thr Lys Thr Asn Asp  Val Arg 
    1040                 1045         


<210> 39
<211> 870
<212> PRT
<213> Homo sapiens

<400> 39
Met Lys Gly Trp Tyr His Gly Lys Leu Asp Arg Thr Ile Ala Glu Glu 
1               5                   10                  15      


Arg Leu Arg Gln Ala Gly Lys Ser Gly Ser Tyr Leu Ile Arg Glu Ser 
            20                  25                  30          


Asp Arg Arg Pro Gly Ser Phe Val Leu Ser Phe Leu Ser Gln Met Asn 
        35                  40                  45              


Val Val Asn His Phe Arg Ile Ile Ala Met Cys Gly Asp Tyr Tyr Ile 
    50                  55                  60                  


Gly Gly Arg Arg Phe Ser Ser Leu Ser Asp Leu Ile Gly Tyr Tyr Ser 
65                  70                  75                  80  


His Val Ser Cys Leu Leu Lys Gly Glu Lys Leu Leu Tyr Pro Val Ala 
                85                  90                  95      


Pro Pro Glu Pro Val Glu Asp Arg Arg Arg Val Arg Ala Ile Leu Pro 
            100                 105                 110         


Tyr Thr Lys Val Pro Asp Thr Asp Glu Ile Ser Phe Leu Lys Gly Asp 
        115                 120                 125             


Met Phe Ile Val His Asn Glu Leu Glu Asp Gly Trp Met Trp Val Thr 
    130                 135                 140                 


Asn Leu Arg Thr Asp Glu Gln Gly Leu Ile Val Glu Asp Leu Val Glu 
145                 150                 155                 160 


Glu Val Gly Arg Glu Glu Asp Pro His Glu Gly Lys Ile Trp Phe His 
                165                 170                 175     


Gly Lys Ile Ser Lys Gln Glu Ala Tyr Asn Leu Leu Met Thr Val Gly 
            180                 185                 190         


Gln Val Cys Ser Phe Leu Val Arg Pro Ser Asp Asn Thr Pro Gly Asp 
        195                 200                 205             


Tyr Ser Leu Tyr Phe Arg Thr Asn Glu Asn Ile Gln Arg Phe Lys Ile 
    210                 215                 220                 


Cys Pro Thr Pro Asn Asn Gln Phe Met Met Gly Gly Arg Tyr Tyr Asn 
225                 230                 235                 240 


Ser Ile Gly Asp Ile Ile Asp His Tyr Arg Lys Glu Gln Ile Val Glu 
                245                 250                 255     


Gly Tyr Tyr Leu Lys Glu Pro Val Pro Met Gln Asp Gln Glu Gln Val 
            260                 265                 270         


Leu Asn Asp Thr Val Asp Gly Lys Glu Ile Tyr Asn Thr Ile Arg Arg 
        275                 280                 285             


Lys Thr Lys Asp Ala Phe Tyr Lys Asn Ile Val Lys Lys Gly Tyr Leu 
    290                 295                 300                 


Leu Lys Lys Gly Lys Gly Lys Arg Trp Lys Asn Leu Tyr Phe Ile Leu 
305                 310                 315                 320 


Glu Gly Ser Asp Ala Gln Leu Ile Tyr Phe Glu Ser Glu Lys Arg Ala 
                325                 330                 335     


Thr Lys Pro Lys Gly Leu Ile Asp Leu Ser Val Cys Ser Val Tyr Val 
            340                 345                 350         


Val His Asp Ser Leu Phe Gly Arg Pro Asn Cys Phe Gln Ile Val Val 
        355                 360                 365             


Gln His Phe Ser Glu Glu His Tyr Ile Phe Tyr Phe Ala Gly Glu Thr 
    370                 375                 380                 


Pro Glu Gln Ala Glu Asp Trp Met Lys Gly Leu Gln Ala Phe Cys Asn 
385                 390                 395                 400 


Leu Arg Lys Ser Ser Pro Gly Thr Ser Asn Lys Arg Leu Arg Gln Val 
                405                 410                 415     


Ser Ser Leu Val Leu His Ile Glu Glu Ala His Lys Leu Pro Val Lys 
            420                 425                 430         


His Phe Thr Asn Pro Tyr Cys Asn Ile Tyr Leu Asn Ser Val Gln Val 
        435                 440                 445             


Ala Lys Thr His Ala Arg Glu Gly Gln Asn Pro Val Trp Ser Glu Glu 
    450                 455                 460                 


Phe Val Phe Asp Asp Leu Pro Pro Asp Ile Asn Arg Phe Glu Ile Thr 
465                 470                 475                 480 


Leu Ser Asn Lys Thr Lys Lys Ser Lys Asp Pro Asp Ile Leu Phe Met 
                485                 490                 495     


Arg Cys Gln Leu Ser Arg Leu Gln Lys Gly His Ala Thr Asp Glu Trp 
            500                 505                 510         


Phe Leu Leu Ser Ser His Ile Pro Leu Lys Gly Ile Glu Pro Gly Ser 
        515                 520                 525             


Leu Arg Val Arg Ala Arg Tyr Ser Met Glu Lys Ile Met Pro Glu Glu 
    530                 535                 540                 


Glu Tyr Ser Glu Phe Lys Glu Leu Ile Leu Gln Lys Glu Leu His Val 
545                 550                 555                 560 


Val Tyr Ala Leu Ser His Val Cys Gly Gln Asp Arg Thr Leu Leu Ala 
                565                 570                 575     


Ser Ile Leu Leu Arg Ile Phe Leu His Glu Lys Leu Glu Ser Leu Leu 
            580                 585                 590         


Leu Cys Thr Leu Asn Asp Arg Glu Ile Ser Met Glu Asp Glu Ala Thr 
        595                 600                 605             


Thr Leu Phe Arg Ala Thr Thr Leu Ala Ser Thr Leu Met Glu Gln Tyr 
    610                 615                 620                 


Met Lys Ala Thr Ala Thr Gln Phe Val His His Ala Leu Lys Asp Ser 
625                 630                 635                 640 


Ile Leu Lys Ile Met Glu Ser Lys Gln Ser Cys Glu Leu Ser Pro Ser 
                645                 650                 655     


Lys Leu Glu Lys Asn Glu Asp Val Asn Thr Asn Leu Thr His Leu Leu 
            660                 665                 670         


Asn Ile Leu Ser Glu Leu Val Glu Lys Ile Phe Met Ala Ser Glu Ile 
        675                 680                 685             


Leu Pro Pro Thr Leu Arg Tyr Ile Tyr Gly Cys Leu Gln Lys Ser Val 
    690                 695                 700                 


Gln His Lys Trp Pro Thr Asn Thr Thr Met Arg Thr Arg Val Val Ser 
705                 710                 715                 720 


Gly Phe Val Phe Leu Arg Leu Ile Cys Pro Ala Ile Leu Asn Pro Arg 
                725                 730                 735     


Met Phe Asn Ile Ile Ser Asp Ser Pro Ser Pro Ile Ala Ala Arg Thr 
            740                 745                 750         


Leu Ile Leu Val Ala Lys Ser Val Gln Asn Leu Ala Asn Leu Val Glu 
        755                 760                 765             


Phe Gly Ala Lys Glu Pro Tyr Met Glu Gly Val Asn Pro Phe Ile Lys 
    770                 775                 780                 


Ser Asn Lys His Arg Met Ile Met Phe Leu Asp Glu Leu Gly Asn Val 
785                 790                 795                 800 


Pro Glu Leu Pro Asp Thr Thr Glu His Ser Arg Thr Asp Leu Ser Arg 
                805                 810                 815     


Asp Leu Ala Ala Leu His Glu Ile Cys Val Ala His Ser Asp Glu Leu 
            820                 825                 830         


Arg Thr Leu Ser Asn Glu Arg Gly Ala Gln Gln His Val Leu Lys Lys 
        835                 840                 845             


Leu Leu Ala Ile Thr Glu Leu Leu Gln Gln Lys Gln Asn Gln Tyr Thr 
    850                 855                 860                 


Lys Thr Asn Asp Val Arg 
865                 870 


<210> 40
<211> 539
<212> PRT
<213> Homo sapiens

<400> 40
Met Met Ala Ala Glu Ala Gly Ser Glu Glu Gly Gly Pro Val Thr Ala 
1               5                   10                  15      


Gly Ala Gly Gly Gly Gly Ala Ala Ala Gly Ser Ser Ala Tyr Pro Ala 
            20                  25                  30          


Val Cys Arg Val Lys Ile Pro Ala Ala Leu Pro Val Ala Ala Ala Pro 
        35                  40                  45              


Tyr Pro Gly Leu Val Glu Thr Gly Val Ala Gly Thr Leu Gly Gly Gly 
    50                  55                  60                  


Ala Ala Leu Gly Ser Glu Phe Leu Gly Ala Gly Ser Val Ala Gly Ala 
65                  70                  75                  80  


Leu Gly Gly Ala Gly Leu Thr Gly Gly Gly Thr Ala Ala Gly Val Ala 
                85                  90                  95      


Gly Ala Ala Ala Gly Val Ala Gly Ala Ala Val Ala Gly Pro Ser Gly 
            100                 105                 110         


Asp Met Ala Leu Thr Lys Leu Pro Thr Ser Leu Leu Ala Glu Thr Leu 
        115                 120                 125             


Gly Pro Gly Gly Gly Phe Pro Pro Leu Pro Pro Pro Pro Tyr Leu Pro 
    130                 135                 140                 


Pro Leu Gly Ala Gly Leu Gly Thr Val Asp Glu Gly Asp Ser Leu Asp 
145                 150                 155                 160 


Gly Pro Glu Tyr Glu Glu Glu Glu Val Ala Ile Pro Leu Thr Ala Pro 
                165                 170                 175     


Pro Thr Asn Gln Trp Tyr His Gly Lys Leu Asp Arg Thr Ile Ala Glu 
            180                 185                 190         


Glu Arg Leu Arg Gln Ala Gly Lys Ser Gly Ser Tyr Leu Ile Arg Glu 
        195                 200                 205             


Ser Asp Arg Arg Pro Gly Ser Phe Val Leu Ser Phe Leu Ser Gln Met 
    210                 215                 220                 


Asn Val Val Asn His Phe Arg Ile Ile Ala Met Cys Gly Asp Tyr Tyr 
225                 230                 235                 240 


Ile Gly Gly Arg Arg Phe Ser Ser Leu Ser Asp Leu Ile Gly Tyr Tyr 
                245                 250                 255     


Ser His Val Ser Cys Leu Leu Lys Gly Glu Lys Leu Leu Tyr Pro Val 
            260                 265                 270         


Ala Pro Pro Glu Pro Val Glu Asp Arg Arg Arg Val Arg Ala Ile Leu 
        275                 280                 285             


Pro Tyr Thr Lys Val Pro Asp Thr Asp Glu Ile Ser Phe Leu Lys Gly 
    290                 295                 300                 


Asp Met Phe Ile Val His Asn Glu Leu Glu Asp Gly Trp Met Trp Val 
305                 310                 315                 320 


Thr Asn Leu Arg Thr Asp Glu Gln Gly Leu Ile Val Glu Asp Leu Val 
                325                 330                 335     


Glu Glu Val Gly Arg Glu Glu Asp Pro His Glu Gly Lys Ile Trp Phe 
            340                 345                 350         


His Gly Lys Ile Ser Lys Gln Glu Ala Tyr Asn Leu Leu Met Thr Val 
        355                 360                 365             


Gly Gln Val Cys Ser Phe Leu Val Arg Pro Ser Asp Asn Thr Pro Gly 
    370                 375                 380                 


Asp Tyr Ser Leu Tyr Phe Arg Thr Asn Glu Asn Ile Gln Arg Phe Lys 
385                 390                 395                 400 


Ile Cys Pro Thr Pro Asn Asn Gln Phe Met Met Gly Gly Arg Tyr Tyr 
                405                 410                 415     


Asn Ser Ile Gly Asp Ile Ile Asp His Tyr Arg Lys Glu Gln Ile Val 
            420                 425                 430         


Glu Gly Tyr Tyr Leu Lys Glu Pro Val Pro Met Gln Asp Gln Glu Gln 
        435                 440                 445             


Val Leu Asn Asp Thr Val Asp Gly Lys Glu Ile Tyr Asn Thr Ile Arg 
    450                 455                 460                 


Arg Lys Thr Lys Asp Ala Phe Tyr Lys Asn Ile Val Lys Lys Gly Tyr 
465                 470                 475                 480 


Leu Leu Lys Lys Gly Lys Gly Lys Arg Trp Lys Asn Leu Tyr Phe Ile 
                485                 490                 495     


Leu Glu Gly Ser Asp Ala Gln Leu Ile Tyr Phe Glu Ser Glu Lys Arg 
            500                 505                 510         


Ala Thr Lys Pro Lys Gly Leu Ile Asp Leu Ser Val Cys Ser Val Tyr 
        515                 520                 525             


Val Val His Asp Ser Leu Phe Gly Arg Cys Ser 
    530                 535                 


<210> 41
<211> 880
<212> PRT
<213> Homo sapiens

<400> 41
Met Arg Thr Gly Tyr Ser Ser Val Pro Ser Lys Leu Arg Trp Tyr His 
1               5                   10                  15      


Gly Lys Leu Asp Arg Thr Ile Ala Glu Glu Arg Leu Arg Gln Ala Gly 
            20                  25                  30          


Lys Ser Gly Ser Tyr Leu Ile Arg Glu Ser Asp Arg Arg Pro Gly Ser 
        35                  40                  45              


Phe Val Leu Ser Phe Leu Ser Gln Met Asn Val Val Asn His Phe Arg 
    50                  55                  60                  


Ile Ile Ala Met Cys Gly Asp Tyr Tyr Ile Gly Gly Arg Arg Phe Ser 
65                  70                  75                  80  


Ser Leu Ser Asp Leu Ile Gly Tyr Tyr Ser His Val Ser Cys Leu Leu 
                85                  90                  95      


Lys Gly Glu Lys Leu Leu Tyr Pro Val Ala Pro Pro Glu Pro Val Glu 
            100                 105                 110         


Asp Arg Arg Arg Val Arg Ala Ile Leu Pro Tyr Thr Lys Val Pro Asp 
        115                 120                 125             


Thr Asp Glu Ile Ser Phe Leu Lys Gly Asp Met Phe Ile Val His Asn 
    130                 135                 140                 


Glu Leu Glu Asp Gly Trp Met Trp Val Thr Asn Leu Arg Thr Asp Glu 
145                 150                 155                 160 


Gln Gly Leu Ile Val Glu Asp Leu Val Glu Glu Val Gly Arg Glu Glu 
                165                 170                 175     


Asp Pro His Glu Gly Lys Ile Trp Phe His Gly Lys Ile Ser Lys Gln 
            180                 185                 190         


Glu Ala Tyr Asn Leu Leu Met Thr Val Gly Gln Val Cys Ser Phe Leu 
        195                 200                 205             


Val Arg Pro Ser Asp Asn Thr Pro Gly Asp Tyr Ser Leu Tyr Phe Arg 
    210                 215                 220                 


Thr Asn Glu Asn Ile Gln Arg Phe Lys Ile Cys Pro Thr Pro Asn Asn 
225                 230                 235                 240 


Gln Phe Met Met Gly Gly Arg Tyr Tyr Asn Ser Ile Gly Asp Ile Ile 
                245                 250                 255     


Asp His Tyr Arg Lys Glu Gln Ile Val Glu Gly Tyr Tyr Leu Lys Glu 
            260                 265                 270         


Pro Val Pro Met Gln Asp Gln Glu Gln Val Leu Asn Asp Thr Val Asp 
        275                 280                 285             


Gly Lys Glu Ile Tyr Asn Thr Ile Arg Arg Lys Thr Lys Asp Ala Phe 
    290                 295                 300                 


Tyr Lys Asn Ile Val Lys Lys Gly Tyr Leu Leu Lys Lys Gly Lys Gly 
305                 310                 315                 320 


Lys Arg Trp Lys Asn Leu Tyr Phe Ile Leu Glu Gly Ser Asp Ala Gln 
                325                 330                 335     


Leu Ile Tyr Phe Glu Ser Glu Lys Arg Ala Thr Lys Pro Lys Gly Leu 
            340                 345                 350         


Ile Asp Leu Ser Val Cys Ser Val Tyr Val Val His Asp Ser Leu Phe 
        355                 360                 365             


Gly Arg Pro Asn Cys Phe Gln Ile Val Val Gln His Phe Ser Glu Glu 
    370                 375                 380                 


His Tyr Ile Phe Tyr Phe Ala Gly Glu Thr Pro Glu Gln Ala Glu Asp 
385                 390                 395                 400 


Trp Met Lys Gly Leu Gln Ala Phe Cys Asn Leu Arg Lys Ser Ser Pro 
                405                 410                 415     


Gly Thr Ser Asn Lys Arg Leu Arg Gln Val Ser Ser Leu Val Leu His 
            420                 425                 430         


Ile Glu Glu Ala His Lys Leu Pro Val Lys His Phe Thr Asn Pro Tyr 
        435                 440                 445             


Cys Asn Ile Tyr Leu Asn Ser Val Gln Val Ala Lys Thr His Ala Arg 
    450                 455                 460                 


Glu Gly Gln Asn Pro Val Trp Ser Glu Glu Phe Val Phe Asp Asp Leu 
465                 470                 475                 480 


Pro Pro Asp Ile Asn Arg Phe Glu Ile Thr Leu Ser Asn Lys Thr Lys 
                485                 490                 495     


Lys Ser Lys Asp Pro Asp Ile Leu Phe Met Arg Cys Gln Leu Ser Arg 
            500                 505                 510         


Leu Gln Lys Gly His Ala Thr Asp Glu Trp Phe Leu Leu Ser Ser His 
        515                 520                 525             


Ile Pro Leu Lys Gly Ile Glu Pro Gly Ser Leu Arg Val Arg Ala Arg 
    530                 535                 540                 


Tyr Ser Met Glu Lys Ile Met Pro Glu Glu Glu Tyr Ser Glu Phe Lys 
545                 550                 555                 560 


Glu Leu Ile Leu Gln Lys Glu Leu His Val Val Tyr Ala Leu Ser His 
                565                 570                 575     


Val Cys Gly Gln Asp Arg Thr Leu Leu Ala Ser Ile Leu Leu Arg Ile 
            580                 585                 590         


Phe Leu His Glu Lys Leu Glu Ser Leu Leu Leu Cys Thr Leu Asn Asp 
        595                 600                 605             


Arg Glu Ile Ser Met Glu Asp Glu Ala Thr Thr Leu Phe Arg Ala Thr 
    610                 615                 620                 


Thr Leu Ala Ser Thr Leu Met Glu Gln Tyr Met Lys Ala Thr Ala Thr 
625                 630                 635                 640 


Gln Phe Val His His Ala Leu Lys Asp Ser Ile Leu Lys Ile Met Glu 
                645                 650                 655     


Ser Lys Gln Ser Cys Glu Leu Ser Pro Ser Lys Leu Glu Lys Asn Glu 
            660                 665                 670         


Asp Val Asn Thr Asn Leu Thr His Leu Leu Asn Ile Leu Ser Glu Leu 
        675                 680                 685             


Val Glu Lys Ile Phe Met Ala Ser Glu Ile Leu Pro Pro Thr Leu Arg 
    690                 695                 700                 


Tyr Ile Tyr Gly Cys Leu Gln Lys Ser Val Gln His Lys Trp Pro Thr 
705                 710                 715                 720 


Asn Thr Thr Met Arg Thr Arg Val Val Ser Gly Phe Val Phe Leu Arg 
                725                 730                 735     


Leu Ile Cys Pro Ala Ile Leu Asn Pro Arg Met Phe Asn Ile Ile Ser 
            740                 745                 750         


Asp Ser Pro Ser Pro Ile Ala Ala Arg Thr Leu Ile Leu Val Ala Lys 
        755                 760                 765             


Ser Val Gln Asn Leu Ala Asn Leu Val Glu Phe Gly Ala Lys Glu Pro 
    770                 775                 780                 


Tyr Met Glu Gly Val Asn Pro Phe Ile Lys Ser Asn Lys His Arg Met 
785                 790                 795                 800 


Ile Met Phe Leu Asp Glu Leu Gly Asn Val Pro Glu Leu Pro Asp Thr 
                805                 810                 815     


Thr Glu His Ser Arg Thr Asp Leu Ser Arg Asp Leu Ala Ala Leu His 
            820                 825                 830         


Glu Ile Cys Val Ala His Ser Asp Glu Leu Arg Thr Leu Ser Asn Glu 
        835                 840                 845             


Arg Gly Ala Gln Gln His Val Leu Lys Lys Leu Leu Ala Ile Thr Glu 
    850                 855                 860                 


Leu Leu Gln Gln Lys Gln Asn Gln Tyr Thr Lys Thr Asn Asp Val Arg 
865                 870                 875                 880 


<210> 42
<211> 304
<212> PRT
<213> Homo sapiens

<400> 42
Met Lys Arg Ala His Pro Glu Tyr Ser Ser Ser Asp Ser Glu Leu Asp 
1               5                   10                  15      


Glu Thr Ile Glu Val Glu Lys Glu Ser Ala Asp Glu Asn Gly Asn Leu 
            20                  25                  30          


Ser Ser Ala Leu Gly Ser Met Ser Pro Thr Thr Ser Ser Gln Ile Leu 
        35                  40                  45              


Ala Arg Lys Arg Arg Arg Gly Ile Ile Glu Lys Arg Arg Arg Asp Arg 
    50                  55                  60                  


Ile Asn Asn Ser Leu Ser Glu Leu Arg Arg Leu Val Pro Ser Ala Phe 
65                  70                  75                  80  


Glu Lys Gln Gly Ser Ala Lys Leu Glu Lys Ala Glu Ile Leu Gln Met 
                85                  90                  95      


Thr Val Asp His Leu Lys Met Leu His Thr Ala Gly Gly Lys Gly Tyr 
            100                 105                 110         


Phe Asp Ala His Ala Leu Ala Met Asp Tyr Arg Ser Leu Gly Phe Arg 
        115                 120                 125             


Glu Cys Leu Ala Glu Val Ala Arg Tyr Leu Ser Ile Ile Glu Gly Leu 
    130                 135                 140                 


Asp Ala Ser Asp Pro Leu Arg Val Arg Leu Val Ser His Leu Asn Asn 
145                 150                 155                 160 


Tyr Ala Ser Gln Arg Glu Ala Ala Ser Gly Ala His Ala Gly Leu Gly 
                165                 170                 175     


His Ile Pro Trp Gly Thr Val Phe Gly His His Pro His Ile Ala His 
            180                 185                 190         


Pro Leu Leu Leu Pro Gln Asn Gly His Gly Asn Ala Gly Thr Thr Ala 
        195                 200                 205             


Ser Pro Thr Glu Pro His His Gln Gly Arg Leu Gly Ser Ala His Pro 
    210                 215                 220                 


Glu Ala Pro Ala Leu Arg Ala Pro Pro Ser Gly Ser Leu Gly Pro Val 
225                 230                 235                 240 


Leu Pro Val Val Thr Ser Ala Ser Lys Leu Ser Pro Pro Leu Leu Ser 
                245                 250                 255     


Ser Val Ala Ser Leu Ser Ala Phe Pro Phe Ser Phe Gly Ser Phe His 
            260                 265                 270         


Leu Leu Ser Pro Asn Ala Leu Ser Pro Ser Ala Pro Thr Gln Ala Ala 
        275                 280                 285             


Asn Leu Gly Lys Pro Tyr Arg Pro Trp Gly Thr Glu Ile Gly Ala Phe 
    290                 295                 300                 


<210> 43
<211> 308
<212> PRT
<213> Homo sapiens

<400> 43
Met Lys Arg Ala His Pro Glu Tyr Ser Ser Ser Asp Ser Glu Leu Asp 
1               5                   10                  15      


Glu Thr Ile Glu Val Glu Lys Glu Ser Ala Asp Glu Asn Gly Asn Leu 
            20                  25                  30          


Ser Ser Ala Leu Gly Ser Met Ser Pro Thr Thr Ser Ser Gln Ile Leu 
        35                  40                  45              


Ala Arg Lys Arg Arg Arg Gly Ile Ile Glu Lys Arg Arg Arg Asp Arg 
    50                  55                  60                  


Ile Asn Asn Ser Leu Ser Glu Leu Arg Arg Leu Val Pro Ser Ala Phe 
65                  70                  75                  80  


Glu Lys Gln Val Met Glu Gln Gly Ser Ala Lys Leu Glu Lys Ala Glu 
                85                  90                  95      


Ile Leu Gln Met Thr Val Asp His Leu Lys Met Leu His Thr Ala Gly 
            100                 105                 110         


Gly Lys Gly Tyr Phe Asp Ala His Ala Leu Ala Met Asp Tyr Arg Ser 
        115                 120                 125             


Leu Gly Phe Arg Glu Cys Leu Ala Glu Val Ala Arg Tyr Leu Ser Ile 
    130                 135                 140                 


Ile Glu Gly Leu Asp Ala Ser Asp Pro Leu Arg Val Arg Leu Val Ser 
145                 150                 155                 160 


His Leu Asn Asn Tyr Ala Ser Gln Arg Glu Ala Ala Ser Gly Ala His 
                165                 170                 175     


Ala Gly Leu Gly His Ile Pro Trp Gly Thr Val Phe Gly His His Pro 
            180                 185                 190         


His Ile Ala His Pro Leu Leu Leu Pro Gln Asn Gly His Gly Asn Ala 
        195                 200                 205             


Gly Thr Thr Ala Ser Pro Thr Glu Pro His His Gln Gly Arg Leu Gly 
    210                 215                 220                 


Ser Ala His Pro Glu Ala Pro Ala Leu Arg Ala Pro Pro Ser Gly Ser 
225                 230                 235                 240 


Leu Gly Pro Val Leu Pro Val Val Thr Ser Ala Ser Lys Leu Ser Pro 
                245                 250                 255     


Pro Leu Leu Ser Ser Val Ala Ser Leu Ser Ala Phe Pro Phe Ser Phe 
            260                 265                 270         


Gly Ser Phe His Leu Leu Ser Pro Asn Ala Leu Ser Pro Ser Ala Pro 
        275                 280                 285             


Thr Gln Ala Ala Asn Leu Gly Lys Pro Tyr Arg Pro Trp Gly Thr Glu 
    290                 295                 300                 


Ile Gly Ala Phe 
305             


<210> 44
<211> 469
<212> PRT
<213> Homo sapiens

<400> 44
Met Asn Asp Phe Gly Ile Lys Asn Met Asp Gln Val Ala Pro Val Ala 
1               5                   10                  15      


Asn Ser Tyr Arg Gly Thr Leu Lys Arg Gln Pro Ala Phe Asp Thr Phe 
            20                  25                  30          


Asp Gly Ser Leu Phe Ala Val Phe Pro Ser Leu Asn Glu Glu Gln Thr 
        35                  40                  45              


Leu Gln Glu Val Pro Thr Gly Leu Asp Ser Ile Ser His Asp Ser Ala 
    50                  55                  60                  


Asn Cys Glu Leu Pro Leu Leu Thr Pro Cys Ser Lys Ala Val Met Ser 
65                  70                  75                  80  


Gln Ala Leu Lys Ala Thr Phe Ser Gly Phe Lys Lys Glu Gln Arg Arg 
                85                  90                  95      


Leu Gly Ile Pro Lys Asn Pro Trp Leu Trp Ser Glu Gln Gln Val Cys 
            100                 105                 110         


Gln Trp Leu Leu Trp Ala Thr Asn Glu Phe Ser Leu Val Asn Val Asn 
        115                 120                 125             


Leu Gln Arg Phe Gly Met Asn Gly Gln Met Leu Cys Asn Leu Gly Lys 
    130                 135                 140                 


Glu Arg Phe Leu Glu Leu Ala Pro Asp Phe Val Gly Asp Ile Leu Trp 
145                 150                 155                 160 


Glu His Leu Glu Gln Met Ile Lys Glu Asn Gln Glu Lys Thr Glu Asp 
                165                 170                 175     


Gln Tyr Glu Glu Asn Ser His Leu Thr Ser Val Pro His Trp Ile Asn 
            180                 185                 190         


Ser Asn Thr Leu Gly Phe Gly Thr Glu Gln Ala Pro Tyr Gly Met Gln 
        195                 200                 205             


Thr Gln Asn Tyr Pro Lys Gly Gly Leu Leu Asp Ser Met Cys Pro Ala 
    210                 215                 220                 


Ser Thr Pro Ser Val Leu Ser Ser Glu Gln Glu Phe Gln Met Phe Pro 
225                 230                 235                 240 


Lys Ser Arg Leu Ser Ser Val Ser Val Thr Tyr Cys Ser Val Ser Gln 
                245                 250                 255     


Asp Phe Pro Gly Ser Asn Leu Asn Leu Leu Thr Asn Asn Ser Gly Thr 
            260                 265                 270         


Pro Lys Asp His Asp Ser Pro Glu Asn Gly Ala Asp Ser Phe Glu Ser 
        275                 280                 285             


Ser Asp Ser Leu Leu Gln Ser Trp Asn Ser Gln Ser Ser Leu Leu Asp 
    290                 295                 300                 


Val Gln Arg Val Pro Ser Phe Glu Ser Phe Glu Asp Asp Cys Ser Gln 
305                 310                 315                 320 


Ser Leu Cys Leu Asn Lys Pro Thr Met Ser Phe Lys Asp Tyr Ile Gln 
                325                 330                 335     


Glu Arg Ser Asp Pro Val Glu Gln Gly Lys Pro Val Ile Pro Ala Ala 
            340                 345                 350         


Val Leu Ala Gly Phe Thr Gly Ser Gly Pro Ile Gln Leu Trp Gln Phe 
        355                 360                 365             


Leu Leu Glu Leu Leu Ser Asp Lys Ser Cys Gln Ser Phe Ile Ser Trp 
    370                 375                 380                 


Thr Gly Asp Gly Trp Glu Phe Lys Leu Ala Asp Pro Asp Glu Val Ala 
385                 390                 395                 400 


Arg Arg Trp Gly Lys Arg Lys Asn Lys Pro Lys Met Asn Tyr Glu Lys 
                405                 410                 415     


Leu Ser Arg Gly Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Ile His Lys 
            420                 425                 430         


Thr Ser Gly Lys Arg Tyr Val Tyr Arg Phe Val Cys Asp Leu Gln Asn 
        435                 440                 445             


Leu Leu Gly Phe Thr Pro Glu Glu Leu His Ala Ile Leu Gly Val Gln 
    450                 455                 460                 


Pro Asp Thr Glu Asp 
465                 


<210> 45
<211> 337
<212> PRT
<213> Homo sapiens

<400> 45
Met Lys Arg Pro Cys Glu Glu Thr Thr Ser Glu Ser Asp Met Asp Glu 
1               5                   10                  15      


Thr Ile Asp Val Gly Ser Glu Asn Asn Tyr Ser Gly Gln Ser Thr Ser 
            20                  25                  30          


Ser Val Ile Arg Leu Asn Ser Pro Thr Thr Thr Ser Gln Ile Met Ala 
        35                  40                  45              


Arg Lys Lys Arg Arg Gly Ile Ile Glu Lys Arg Arg Arg Asp Arg Ile 
    50                  55                  60                  


Asn Asn Ser Leu Ser Glu Leu Arg Arg Leu Val Pro Thr Ala Phe Glu 
65                  70                  75                  80  


Lys Gln Gly Ser Ala Lys Leu Glu Lys Ala Glu Ile Leu Gln Met Thr 
                85                  90                  95      


Val Asp His Leu Lys Met Leu Gln Ala Thr Gly Gly Lys Gly Tyr Phe 
            100                 105                 110         


Asp Ala His Ala Leu Ala Met Asp Phe Met Ser Ile Gly Phe Arg Glu 
        115                 120                 125             


Cys Leu Thr Glu Val Ala Arg Tyr Leu Ser Ser Val Glu Gly Leu Asp 
    130                 135                 140                 


Ser Ser Asp Pro Leu Arg Val Arg Leu Val Ser His Leu Ser Thr Cys 
145                 150                 155                 160 


Ala Thr Gln Arg Glu Ala Ala Ala Met Thr Ser Ser Met Ala His His 
                165                 170                 175     


His His Pro Leu His Pro His His Trp Ala Ala Ala Phe His His Leu 
            180                 185                 190         


Pro Ala Ala Leu Leu Gln Pro Asn Gly Leu His Ala Ser Glu Ser Thr 
        195                 200                 205             


Pro Cys Arg Leu Ser Thr Thr Ser Glu Val Pro Pro Ala His Gly Ser 
    210                 215                 220                 


Ala Leu Leu Thr Ala Thr Phe Ala His Ala Asp Ser Ala Leu Arg Met 
225                 230                 235                 240 


Pro Ser Thr Gly Ser Val Ala Pro Cys Val Pro Pro Leu Ser Thr Ser 
                245                 250                 255     


Leu Leu Ser Leu Ser Ala Thr Val His Ala Ala Ala Ala Ala Ala Thr 
            260                 265                 270         


Ala Ala Ala His Ser Phe Pro Leu Ser Phe Ala Gly Ala Phe Pro Met 
        275                 280                 285             


Leu Pro Pro Asn Ala Ala Ala Ala Val Ala Ala Ala Thr Ala Ile Ser 
    290                 295                 300                 


Pro Pro Leu Ser Val Ser Ala Thr Ser Ser Pro Gln Gln Thr Ser Ser 
305                 310                 315                 320 


Gly Thr Asn Asn Lys Pro Tyr Arg Pro Trp Gly Thr Glu Val Gly Ala 
                325                 330                 335     


Phe 
    


<210> 46
<211> 411
<212> PRT
<213> Homo sapiens

<400> 46
Met Ser Val Gly Cys Ala Cys Pro Gly Cys Ser Ser Lys Ser Phe Lys 
1               5                   10                  15      


Leu Tyr Ser Pro Lys Glu Pro Pro Asn Gly Asn Ala Phe Pro Pro Phe 
            20                  25                  30          


His Pro Gly Thr Met Leu Asp Arg Asp Val Gly Pro Thr Pro Met Tyr 
        35                  40                  45              


Pro Pro Thr Tyr Leu Glu Pro Gly Ile Gly Arg His Thr Pro Tyr Gly 
    50                  55                  60                  


Asn Gln Thr Asp Tyr Arg Ile Phe Glu Leu Asn Lys Arg Leu Gln Asn 
65                  70                  75                  80  


Trp Thr Glu Glu Cys Asp Asn Leu Trp Trp Asp Ala Phe Thr Thr Glu 
                85                  90                  95      


Phe Phe Glu Asp Asp Ala Met Leu Thr Ile Thr Phe Cys Leu Glu Asp 
            100                 105                 110         


Gly Pro Lys Arg Tyr Thr Ile Gly Arg Thr Leu Ile Pro Arg Tyr Phe 
        115                 120                 125             


Arg Ser Ile Phe Glu Gly Gly Ala Thr Glu Leu Tyr Tyr Val Leu Lys 
    130                 135                 140                 


His Pro Lys Glu Ala Phe His Ser Asn Phe Val Ser Leu Asp Cys Asp 
145                 150                 155                 160 


Gln Gly Ser Met Val Thr Gln His Gly Lys Pro Met Phe Thr Gln Val 
                165                 170                 175     


Cys Val Glu Gly Arg Leu Tyr Leu Glu Phe Met Phe Asp Asp Met Met 
            180                 185                 190         


Arg Ile Lys Thr Trp His Phe Ser Ile Arg Gln His Arg Glu Leu Ile 
        195                 200                 205             


Pro Arg Ser Ile Leu Ala Met His Ala Gln Asp Pro Gln Met Leu Asp 
    210                 215                 220                 


Gln Leu Ser Lys Asn Ile Thr Arg Cys Gly Leu Ser Asn Ser Thr Leu 
225                 230                 235                 240 


Asn Tyr Leu Arg Leu Cys Val Ile Leu Glu Pro Met Gln Glu Leu Met 
                245                 250                 255     


Ser Arg His Lys Thr Tyr Ser Leu Ser Pro Arg Asp Cys Leu Lys Thr 
            260                 265                 270         


Cys Leu Phe Gln Lys Trp Gln Arg Met Val Ala Pro Pro Ala Glu Pro 
        275                 280                 285             


Thr Arg Gln Gln Pro Ser Lys Arg Arg Lys Arg Lys Met Ser Gly Gly 
    290                 295                 300                 


Ser Thr Met Ser Ser Gly Gly Gly Asn Thr Asn Asn Ser Asn Ser Lys 
305                 310                 315                 320 


Lys Lys Ser Pro Ala Ser Thr Phe Ala Leu Ser Ser Gln Val Pro Asp 
                325                 330                 335     


Val Met Val Val Gly Glu Pro Thr Leu Met Gly Gly Glu Phe Gly Asp 
            340                 345                 350         


Glu Asp Glu Arg Leu Ile Thr Arg Leu Glu Asn Thr Gln Phe Asp Ala 
        355                 360                 365             


Ala Asn Gly Ile Asp Asp Glu Asp Ser Phe Asn Asn Ser Pro Ala Leu 
    370                 375                 380                 


Gly Ala Asn Ser Pro Trp Asn Ser Lys Pro Pro Ser Ser Gln Glu Ser 
385                 390                 395                 400 


Lys Ser Glu Asn Pro Thr Ser Gln Ala Ser Gln 
                405                 410     


<210> 47
<211> 316
<212> PRT
<213> Homo sapiens

<400> 47
Met Leu Asp Arg Asp Val Gly Pro Thr Pro Met Tyr Pro Pro Thr Tyr 
1               5                   10                  15      


Leu Glu Pro Gly Ile Gly Arg His Thr Pro Tyr Gly Asn Gln Thr Asp 
            20                  25                  30          


Tyr Arg Ile Phe Glu Leu Asn Lys Arg Leu Gln Asn Trp Thr Glu Glu 
        35                  40                  45              


Cys Asp Asn Leu Trp Trp Asp Ala Phe Thr Thr Glu Phe Phe Glu Asp 
    50                  55                  60                  


Asp Ala Met Leu Thr Ile Thr Phe Cys Leu Glu Asp Gly Pro Lys Arg 
65                  70                  75                  80  


Tyr Thr Ile Gly Arg Thr Leu Ile Pro Arg Tyr Phe Arg Ser Ile Phe 
                85                  90                  95      


Glu Gly Gly Ala Thr Glu Leu Tyr Tyr Val Leu Lys His Pro Lys Glu 
            100                 105                 110         


Ala Phe His Ser Asn Phe Val Ser Leu Asp Cys Asp Gln Gly Ser Met 
        115                 120                 125             


Val Thr Gln His Gly Lys Pro Met Phe Thr Gln Val Cys Val Glu Gly 
    130                 135                 140                 


Arg Leu Tyr Leu Glu Phe Met Phe Asp Asp Met Met Arg Ile Lys Thr 
145                 150                 155                 160 


Trp His Phe Ser Ile Arg Gln His Arg Glu Leu Ile Pro Arg Ser Ile 
                165                 170                 175     


Leu Ala Met His Ala Gln Asp Pro Gln Met Leu Asp Gln Leu Ser Lys 
            180                 185                 190         


Asn Ile Thr Arg Cys Gly Leu Ser Asn Ser Thr Leu Asn Tyr Leu Arg 
        195                 200                 205             


Leu Cys Val Ile Leu Glu Pro Met Gln Glu Leu Met Ser Arg His Lys 
    210                 215                 220                 


Thr Tyr Ser Leu Ser Pro Arg Asp Cys Leu Lys Thr Cys Leu Phe Gln 
225                 230                 235                 240 


Lys Trp Gln Arg Met Val Ala Pro Pro Ala Glu Pro Thr Arg Gln Gln 
                245                 250                 255     


Pro Ser Lys Arg Arg Lys Arg Lys Met Ser Gly Gly Ser Thr Met Ser 
            260                 265                 270         


Ser Gly Gly Gly Asn Thr Asn Asn Ser Asn Ser Lys Lys Lys Ser Pro 
        275                 280                 285             


Ala Ser Thr Phe Ala Leu Ser Ser Gln Val Pro Val Ser Ile Ser Ala 
    290                 295                 300                 


Phe Phe Ser Leu Leu Gly Cys Pro Thr Thr His Pro 
305                 310                 315     


<210> 48
<211> 375
<212> PRT
<213> Homo sapiens

<400> 48
Met Leu Asp Arg Asp Val Gly Pro Thr Pro Met Tyr Pro Pro Thr Tyr 
1               5                   10                  15      


Leu Glu Pro Gly Ile Gly Arg His Thr Pro Tyr Gly Asn Gln Thr Asp 
            20                  25                  30          


Tyr Arg Ile Phe Glu Leu Asn Lys Arg Leu Gln Asn Trp Thr Glu Glu 
        35                  40                  45              


Cys Asp Asn Leu Trp Trp Asp Ala Phe Thr Thr Glu Phe Phe Glu Asp 
    50                  55                  60                  


Asp Ala Met Leu Thr Ile Thr Phe Cys Leu Glu Asp Gly Pro Lys Arg 
65                  70                  75                  80  


Tyr Thr Ile Gly Arg Thr Leu Ile Pro Arg Tyr Phe Arg Ser Ile Phe 
                85                  90                  95      


Glu Gly Gly Ala Thr Glu Leu Tyr Tyr Val Leu Lys His Pro Lys Glu 
            100                 105                 110         


Ala Phe His Ser Asn Phe Val Ser Leu Asp Cys Asp Gln Gly Ser Met 
        115                 120                 125             


Val Thr Gln His Gly Lys Pro Met Phe Thr Gln Val Cys Val Glu Gly 
    130                 135                 140                 


Arg Leu Tyr Leu Glu Phe Met Phe Asp Asp Met Met Arg Ile Lys Thr 
145                 150                 155                 160 


Trp His Phe Ser Ile Arg Gln His Arg Glu Leu Ile Pro Arg Ser Ile 
                165                 170                 175     


Leu Ala Met His Ala Gln Asp Pro Gln Met Leu Asp Gln Leu Ser Lys 
            180                 185                 190         


Asn Ile Thr Arg Cys Gly Leu Ser Asn Ser Thr Leu Asn Tyr Leu Arg 
        195                 200                 205             


Leu Cys Val Ile Leu Glu Pro Met Gln Glu Leu Met Ser Arg His Lys 
    210                 215                 220                 


Thr Tyr Ser Leu Ser Pro Arg Asp Cys Leu Lys Thr Cys Leu Phe Gln 
225                 230                 235                 240 


Lys Trp Gln Arg Met Val Ala Pro Pro Ala Glu Pro Thr Arg Gln Gln 
                245                 250                 255     


Pro Ser Lys Arg Arg Lys Arg Lys Met Ser Gly Gly Ser Thr Met Ser 
            260                 265                 270         


Ser Gly Gly Gly Asn Thr Asn Asn Ser Asn Ser Lys Lys Lys Ser Pro 
        275                 280                 285             


Ala Ser Thr Phe Ala Leu Ser Ser Gln Val Pro Asp Val Met Val Val 
    290                 295                 300                 


Gly Glu Pro Thr Leu Met Gly Gly Glu Phe Gly Asp Glu Asp Glu Arg 
305                 310                 315                 320 


Leu Ile Thr Arg Leu Glu Asn Thr Gln Phe Asp Ala Ala Asn Gly Ile 
                325                 330                 335     


Asp Asp Glu Asp Ser Phe Asn Asn Ser Pro Ala Leu Gly Ala Asn Ser 
            340                 345                 350         


Pro Trp Asn Ser Lys Pro Pro Ser Ser Gln Glu Ser Lys Ser Glu Asn 
        355                 360                 365             


Pro Thr Ser Gln Ala Ser Gln 
    370                 375 


<210> 49
<211> 931
<212> PRT
<213> Homo sapiens

<400> 49
Met Arg Lys Gly Leu Arg Ala Thr Ala Ala Arg Cys Gly Leu Gly Leu 
1               5                   10                  15      


Gly Tyr Leu Leu Gln Met Leu Val Leu Pro Ala Leu Ala Leu Leu Ser 
            20                  25                  30          


Ala Ser Gly Thr Gly Ser Ala Ala Gln Asp Asp Asp Phe Phe His Glu 
        35                  40                  45              


Leu Pro Glu Thr Phe Pro Ser Asp Pro Pro Glu Pro Leu Pro His Phe 
    50                  55                  60                  


Leu Ile Glu Pro Glu Glu Ala Tyr Ile Val Lys Asn Lys Pro Val Asn 
65                  70                  75                  80  


Leu Tyr Cys Lys Ala Ser Pro Ala Thr Gln Ile Tyr Phe Lys Cys Asn 
                85                  90                  95      


Ser Glu Trp Val His Gln Lys Asp His Ile Val Asp Glu Arg Val Asp 
            100                 105                 110         


Glu Thr Ser Gly Leu Ile Val Arg Glu Val Ser Ile Glu Ile Ser Arg 
        115                 120                 125             


Gln Gln Val Glu Glu Leu Phe Gly Pro Glu Asp Tyr Trp Cys Gln Cys 
    130                 135                 140                 


Val Ala Trp Ser Ser Ala Gly Thr Thr Lys Ser Arg Lys Ala Tyr Val 
145                 150                 155                 160 


Arg Ile Ala Tyr Leu Arg Lys Thr Phe Glu Gln Glu Pro Leu Gly Lys 
                165                 170                 175     


Glu Val Ser Leu Glu Gln Glu Val Leu Leu Gln Cys Arg Pro Pro Glu 
            180                 185                 190         


Gly Ile Pro Val Ala Glu Val Glu Trp Leu Lys Asn Glu Asp Ile Ile 
        195                 200                 205             


Asp Pro Val Glu Asp Arg Asn Phe Tyr Ile Thr Ile Asp His Asn Leu 
    210                 215                 220                 


Ile Ile Lys Gln Ala Arg Leu Ser Asp Thr Ala Asn Tyr Thr Cys Val 
225                 230                 235                 240 


Ala Lys Asn Ile Val Ala Lys Arg Lys Ser Thr Thr Ala Thr Val Ile 
                245                 250                 255     


Val Tyr Val Asn Gly Gly Trp Ser Thr Trp Thr Glu Trp Ser Val Cys 
            260                 265                 270         


Asn Ser Arg Cys Gly Arg Gly Tyr Gln Lys Arg Thr Arg Thr Cys Thr 
        275                 280                 285             


Asn Pro Ala Pro Leu Asn Gly Gly Ala Phe Cys Glu Gly Gln Ser Val 
    290                 295                 300                 


Gln Lys Ile Ala Cys Thr Thr Leu Cys Pro Val Asp Gly Arg Trp Thr 
305                 310                 315                 320 


Pro Trp Ser Lys Trp Ser Thr Cys Gly Thr Glu Cys Thr His Trp Arg 
                325                 330                 335     


Arg Arg Glu Cys Thr Ala Pro Ala Pro Lys Asn Gly Gly Lys Asp Cys 
            340                 345                 350         


Asp Gly Leu Val Leu Gln Ser Lys Asn Cys Thr Asp Gly Leu Cys Met 
        355                 360                 365             


Gln Thr Ala Pro Asp Ser Asp Asp Val Ala Leu Tyr Val Gly Ile Val 
    370                 375                 380                 


Ile Ala Val Ile Val Cys Leu Ala Ile Ser Val Val Val Ala Leu Phe 
385                 390                 395                 400 


Val Tyr Arg Lys Asn His Arg Asp Phe Glu Ser Asp Ile Ile Asp Ser 
                405                 410                 415     


Ser Ala Leu Asn Gly Gly Phe Gln Pro Val Asn Ile Lys Ala Ala Arg 
            420                 425                 430         


Gln Asp Leu Leu Ala Val Pro Pro Asp Leu Thr Ser Ala Ala Ala Met 
        435                 440                 445             


Tyr Arg Gly Pro Val Tyr Ala Leu His Asp Val Ser Asp Lys Ile Pro 
    450                 455                 460                 


Met Thr Asn Ser Pro Ile Leu Asp Pro Leu Pro Asn Leu Lys Ile Lys 
465                 470                 475                 480 


Val Tyr Asn Thr Ser Gly Ala Val Thr Pro Gln Asp Asp Leu Ser Glu 
                485                 490                 495     


Phe Thr Ser Lys Leu Ser Pro Gln Met Thr Gln Ser Leu Leu Glu Asn 
            500                 505                 510         


Glu Ala Leu Ser Leu Lys Asn Gln Ser Leu Ala Arg Gln Thr Asp Pro 
        515                 520                 525             


Ser Cys Thr Ala Phe Gly Ser Phe Asn Ser Leu Gly Gly His Leu Ile 
    530                 535                 540                 


Val Pro Asn Ser Gly Val Ser Leu Leu Ile Pro Ala Gly Ala Ile Pro 
545                 550                 555                 560 


Gln Gly Arg Val Tyr Glu Met Tyr Val Thr Val His Arg Lys Glu Thr 
                565                 570                 575     


Met Arg Pro Pro Met Asp Asp Ser Gln Thr Leu Leu Thr Pro Val Val 
            580                 585                 590         


Ser Cys Gly Pro Pro Gly Ala Leu Leu Thr Arg Pro Val Val Leu Thr 
        595                 600                 605             


Met His His Cys Ala Asp Pro Asn Thr Glu Asp Trp Lys Ile Leu Leu 
    610                 615                 620                 


Lys Asn Gln Ala Ala Gln Gly Gln Trp Glu Asp Val Val Val Val Gly 
625                 630                 635                 640 


Glu Glu Asn Phe Thr Thr Pro Cys Tyr Ile Gln Leu Asp Ala Glu Ala 
                645                 650                 655     


Cys His Ile Leu Thr Glu Asn Leu Ser Thr Tyr Ala Leu Val Gly His 
            660                 665                 670         


Ser Thr Thr Lys Ala Ala Ala Lys Arg Leu Lys Leu Ala Ile Phe Gly 
        675                 680                 685             


Pro Leu Cys Cys Ser Ser Leu Glu Tyr Ser Ile Arg Val Tyr Cys Leu 
    690                 695                 700                 


Asp Asp Thr Gln Asp Ala Leu Lys Glu Ile Leu His Leu Glu Arg Gln 
705                 710                 715                 720 


Met Gly Gly Gln Leu Leu Glu Glu Pro Lys Ala Leu His Phe Lys Gly 
                725                 730                 735     


Ser Thr His Asn Leu Arg Leu Ser Ile His Asp Ile Ala His Ser Leu 
            740                 745                 750         


Trp Lys Ser Lys Leu Leu Ala Lys Tyr Gln Glu Ile Pro Phe Tyr His 
        755                 760                 765             


Val Trp Ser Gly Ser Gln Arg Asn Leu His Cys Thr Phe Thr Leu Glu 
    770                 775                 780                 


Arg Phe Ser Leu Asn Thr Val Glu Leu Val Cys Lys Leu Cys Val Arg 
785                 790                 795                 800 


Gln Val Glu Gly Glu Gly Gln Ile Phe Gln Leu Asn Cys Thr Val Ser 
                805                 810                 815     


Glu Glu Pro Thr Gly Ile Asp Leu Pro Leu Leu Asp Pro Ala Asn Thr 
            820                 825                 830         


Ile Thr Thr Val Thr Gly Pro Ser Ala Phe Ser Ile Pro Leu Pro Ile 
        835                 840                 845             


Arg Gln Lys Leu Cys Ser Ser Leu Asp Ala Pro Gln Thr Arg Gly His 
    850                 855                 860                 


Asp Trp Arg Met Leu Ala His Lys Leu Asn Leu Asp Arg Tyr Leu Asn 
865                 870                 875                 880 


Tyr Phe Ala Thr Lys Ser Ser Pro Thr Gly Val Ile Leu Asp Leu Trp 
                885                 890                 895     


Glu Ala Gln Asn Phe Pro Asp Gly Asn Leu Ser Met Leu Ala Ala Val 
            900                 905                 910         


Leu Glu Glu Met Gly Arg His Glu Thr Val Val Ser Leu Ala Ala Glu 
        915                 920                 925             


Gly Gln Tyr 
    930     


<210> 50
<211> 597
<212> PRT
<213> Homo sapiens

<400> 50
Met Arg Lys Gly Leu Arg Ala Thr Ala Ala Arg Cys Gly Leu Gly Leu 
1               5                   10                  15      


Gly Tyr Leu Leu Gln Met Leu Val Leu Pro Ala Leu Ala Leu Leu Ser 
            20                  25                  30          


Ala Ser Gly Thr Gly Ser Ala Ala Gln Asp Asp Asp Phe Phe His Glu 
        35                  40                  45              


Leu Pro Glu Thr Phe Pro Ser Asp Pro Pro Glu Pro Leu Pro His Phe 
    50                  55                  60                  


Leu Ile Glu Pro Glu Glu Ala Tyr Ile Val Lys Asn Lys Pro Val Asn 
65                  70                  75                  80  


Leu Tyr Cys Lys Ala Ser Pro Ala Thr Gln Ile Tyr Phe Lys Cys Asn 
                85                  90                  95      


Ser Glu Trp Val His Gln Lys Asp His Ile Val Asp Glu Arg Val Asp 
            100                 105                 110         


Glu Thr Ser Gly Leu Ile Val Arg Glu Val Ser Ile Glu Ile Ser Arg 
        115                 120                 125             


Gln Gln Val Glu Glu Leu Phe Gly Pro Glu Asp Tyr Trp Cys Gln Cys 
    130                 135                 140                 


Val Ala Trp Ser Ser Ala Gly Thr Thr Lys Ser Arg Lys Ala Tyr Val 
145                 150                 155                 160 


Arg Ile Ala Tyr Leu Arg Lys Thr Phe Glu Gln Glu Pro Leu Gly Lys 
                165                 170                 175     


Glu Val Ser Leu Glu Gln Glu Val Leu Leu Gln Cys Arg Pro Pro Glu 
            180                 185                 190         


Gly Ile Pro Val Ala Glu Val Glu Trp Leu Lys Asn Glu Asp Ile Ile 
        195                 200                 205             


Asp Pro Val Glu Asp Arg Asn Phe Tyr Ile Thr Ile Asp His Asn Leu 
    210                 215                 220                 


Ile Ile Lys Gln Ala Arg Leu Ser Asp Thr Ala Asn Tyr Thr Cys Val 
225                 230                 235                 240 


Ala Lys Asn Ile Val Ala Lys Arg Lys Ser Thr Thr Ala Thr Val Ile 
                245                 250                 255     


Val Tyr Val Asn Gly Gly Trp Ser Thr Trp Thr Glu Trp Ser Val Cys 
            260                 265                 270         


Asn Ser Arg Cys Gly Arg Gly Tyr Gln Lys Arg Thr Arg Thr Cys Thr 
        275                 280                 285             


Asn Pro Ala Pro Leu Asn Gly Gly Ala Phe Cys Glu Gly Gln Ser Val 
    290                 295                 300                 


Gln Lys Ile Ala Cys Thr Thr Leu Cys Pro Val Asp Gly Arg Trp Thr 
305                 310                 315                 320 


Pro Trp Ser Lys Trp Ser Thr Cys Gly Thr Glu Cys Thr His Trp Arg 
                325                 330                 335     


Arg Arg Glu Cys Thr Ala Pro Ala Pro Lys Asn Gly Gly Lys Asp Cys 
            340                 345                 350         


Asp Gly Leu Val Leu Gln Ser Lys Asn Cys Thr Asp Gly Leu Cys Met 
        355                 360                 365             


Gln Ser Phe Ile Tyr Pro Ile Ser Thr Glu Gln Arg Thr Gln Asn Glu 
    370                 375                 380                 


Tyr Gly Phe Ser Ser Ala Pro Asp Ser Asp Asp Val Ala Leu Tyr Val 
385                 390                 395                 400 


Gly Ile Val Ile Ala Val Ile Val Cys Leu Ala Ile Ser Val Val Val 
                405                 410                 415     


Ala Leu Phe Val Tyr Arg Lys Asn His Arg Asp Phe Glu Ser Asp Ile 
            420                 425                 430         


Ile Asp Ser Ser Ala Leu Asn Gly Gly Phe Gln Pro Val Asn Ile Lys 
        435                 440                 445             


Ala Ala Arg Gln Asp Leu Leu Ala Val Pro Pro Asp Leu Thr Ser Ala 
    450                 455                 460                 


Ala Ala Met Tyr Arg Gly Pro Val Tyr Ala Leu His Asp Val Ser Asp 
465                 470                 475                 480 


Lys Ile Pro Met Thr Asn Ser Pro Ile Leu Asp Pro Leu Pro Asn Leu 
                485                 490                 495     


Lys Ile Lys Val Tyr Asn Thr Ser Gly Ala Val Thr Pro Gln Asp Asp 
            500                 505                 510         


Leu Ser Glu Phe Thr Ser Lys Leu Ser Pro Gln Met Thr Gln Ser Leu 
        515                 520                 525             


Leu Glu Asn Glu Ala Leu Ser Leu Lys Asn Gln Ser Leu Ala Arg Gln 
    530                 535                 540                 


Thr Asp Pro Ser Cys Thr Ala Phe Gly Ser Phe Asn Ser Leu Gly Gly 
545                 550                 555                 560 


His Leu Ile Val Pro Asn Ser Gly Val Ser Leu Leu Ile Pro Ala Gly 
                565                 570                 575     


Ala Ile Pro Gln Gly Arg Val Tyr Glu Met Tyr Val Thr Val His Arg 
            580                 585                 590         


Lys Glu Thr Met Arg 
        595         


<210> 51
<211> 2839
<212> PRT
<213> Homo sapiens

<400> 51
Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu 
545                 550                 555                 560 


Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Ser Ser Gln 
                565                 570                 575     


Met Leu Phe Tyr Ile Cys Lys Lys Leu Thr Ser His Gln Met Leu Ser 
            580                 585                 590         


Ser Thr Glu Ile Leu Lys Trp Leu Arg Glu Ile Leu Ile Cys Arg Asn 
        595                 600                 605             


Lys Phe Leu Leu Lys Asn Lys Gln Ala Asp Arg Ser Ser Cys His Phe 
    610                 615                 620                 


Leu Leu Phe Tyr Gly Val Gly Cys Asp Ile Pro Ser Ser Gly Asn Thr 
625                 630                 635                 640 


Ser Gln Met Ser Met Asp His Glu Glu Leu Leu Arg Thr Pro Gly Ala 
                645                 650                 655     


Ser Leu Arg Lys Gly Lys Gly Asn Ser Ser Met Asp Ser Ala Ala Gly 
            660                 665                 670         


Cys Ser Gly Thr Pro Pro Ile Cys Arg Gln Ala Gln Thr Lys Leu Glu 
        675                 680                 685             


Val Ala Leu Tyr Met Phe Leu Trp Asn Pro Asp Thr Glu Ala Val Leu 
    690                 695                 700                 


Val Ala Met Ser Cys Phe Arg His Leu Cys Glu Glu Ala Asp Ile Arg 
705                 710                 715                 720 


Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn Tyr Asn 
                725                 730                 735     


Thr Phe Met Glu Phe Ala Ser Val Ser Asn Met Met Ser Thr Gly Arg 
            740                 745                 750         


Ala Ala Leu Gln Lys Arg Val Met Ala Leu Leu Arg Arg Ile Glu His 
        755                 760                 765             


Pro Thr Ala Gly Asn Thr Glu Ala Trp Glu Asp Thr His Ala Lys Trp 
    770                 775                 780                 


Glu Gln Ala Thr Lys Leu Ile Leu Asn Tyr Pro Lys Ala Lys Met Glu 
785                 790                 795                 800 


Asp Gly Gln Ala Ala Glu Ser Leu His Lys Thr Ile Val Lys Arg Arg 
                805                 810                 815     


Met Ser His Val Ser Gly Gly Gly Ser Ile Asp Leu Ser Asp Thr Asp 
            820                 825                 830         


Ser Leu Gln Glu Trp Ile Asn Met Thr Gly Phe Leu Cys Ala Leu Gly 
        835                 840                 845             


Gly Val Cys Leu Gln Gln Arg Ser Asn Ser Gly Leu Ala Thr Tyr Ser 
    850                 855                 860                 


Pro Pro Met Gly Pro Val Ser Glu Arg Lys Gly Ser Met Ile Ser Val 
865                 870                 875                 880 


Met Ser Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Phe Met Asp 
                885                 890                 895     


Arg Leu Leu Ser Leu Met Val Cys Asn His Glu Lys Val Gly Leu Gln 
            900                 905                 910         


Ile Arg Thr Asn Val Lys Asp Leu Val Gly Leu Glu Leu Ser Pro Ala 
        915                 920                 925             


Leu Tyr Pro Met Leu Phe Asn Lys Leu Lys Asn Thr Ile Ser Lys Phe 
    930                 935                 940                 


Phe Asp Ser Gln Gly Gln Val Leu Leu Thr Asp Thr Asn Thr Gln Phe 
945                 950                 955                 960 


Val Glu Gln Thr Ile Ala Ile Met Lys Asn Leu Leu Asp Asn His Thr 
                965                 970                 975     


Glu Gly Ser Ser Glu His Leu Gly Gln Ala Ser Ile Glu Thr Met Met 
            980                 985                 990         


Leu Asn Leu Val Arg Tyr Val Arg  Val Leu Gly Asn Met  Val His Ala 
        995                 1000                 1005             


Ile Gln  Ile Lys Thr Lys Leu  Cys Gln Leu Val Glu  Val Met Met 
    1010                 1015                 1020             


Ala Arg  Arg Asp Asp Leu Ser  Phe Cys Gln Glu Met  Lys Phe Arg 
    1025                 1030                 1035             


Asn Lys  Met Val Glu Tyr Leu  Thr Asp Trp Val Met  Gly Thr Ser 
    1040                 1045                 1050             


Asn Gln  Ala Ala Asp Asp Asp  Val Lys Cys Leu Thr  Arg Asp Leu 
    1055                 1060                 1065             


Asp Gln  Ala Ser Met Glu Ala  Val Val Ser Leu Leu  Ala Gly Leu 
    1070                 1075                 1080             


Pro Leu  Gln Pro Glu Glu Gly  Asp Gly Val Glu Leu  Met Glu Ala 
    1085                 1090                 1095             


Lys Ser  Gln Leu Phe Leu Lys  Tyr Phe Thr Leu Phe  Met Asn Leu 
    1100                 1105                 1110             


Leu Asn  Asp Cys Ser Glu Val  Glu Asp Glu Ser Ala  Gln Thr Gly 
    1115                 1120                 1125             


Gly Arg  Lys Arg Gly Met Ser  Arg Arg Leu Ala Ser  Leu Arg His 
    1130                 1135                 1140             


Cys Thr  Val Leu Ala Met Ser  Asn Leu Leu Asn Ala  Asn Val Asp 
    1145                 1150                 1155             


Ser Gly  Leu Met His Ser Ile  Gly Leu Gly Tyr His  Lys Asp Leu 
    1160                 1165                 1170             


Gln Thr  Arg Ala Thr Phe Met  Glu Val Leu Thr Lys  Ile Leu Gln 
    1175                 1180                 1185             


Gln Gly  Thr Glu Phe Asp Thr  Leu Ala Glu Thr Val  Leu Ala Asp 
    1190                 1195                 1200             


Arg Phe  Glu Arg Leu Val Glu  Leu Val Thr Met Met  Gly Asp Gln 
    1205                 1210                 1215             


Gly Glu  Leu Pro Ile Ala Met  Ala Leu Ala Asn Val  Val Pro Cys 
    1220                 1225                 1230             


Ser Gln  Trp Asp Glu Leu Ala  Arg Val Leu Val Thr  Leu Phe Asp 
    1235                 1240                 1245             


Ser Arg  His Leu Leu Tyr Gln  Leu Leu Trp Asn Met  Phe Ser Lys 
    1250                 1255                 1260             


Glu Val  Glu Leu Ala Asp Ser  Met Gln Thr Leu Phe  Arg Gly Asn 
    1265                 1270                 1275             


Ser Leu  Ala Ser Lys Ile Met  Thr Phe Cys Phe Lys  Val Tyr Gly 
    1280                 1285                 1290             


Ala Thr  Tyr Leu Gln Lys Leu  Leu Asp Pro Leu Leu  Arg Ile Val 
    1295                 1300                 1305             


Ile Thr  Ser Ser Asp Trp Gln  His Val Ser Phe Glu  Val Asp Pro 
    1310                 1315                 1320             


Thr Arg  Leu Glu Pro Ser Glu  Ser Leu Glu Glu Asn  Gln Arg Asn 
    1325                 1330                 1335             


Leu Leu  Gln Met Thr Glu Lys  Phe Phe His Ala Ile  Ile Ser Ser 
    1340                 1345                 1350             


Ser Ser  Glu Phe Pro Pro Gln  Leu Arg Ser Val Cys  His Cys Leu 
    1355                 1360                 1365             


Tyr Gln  Ala Thr Cys His Ser  Leu Leu Asn Lys Ala  Thr Val Lys 
    1370                 1375                 1380             


Glu Lys  Lys Glu Asn Lys Lys  Ser Val Val Ser Gln  Arg Phe Pro 
    1385                 1390                 1395             


Gln Asn  Ser Ile Gly Ala Val  Gly Ser Ala Met Phe  Leu Arg Phe 
    1400                 1405                 1410             


Ile Asn  Pro Ala Ile Val Ser  Pro Tyr Glu Ala Gly  Ile Leu Asp 
    1415                 1420                 1425             


Lys Lys  Pro Pro Pro Arg Ile  Glu Arg Gly Leu Lys  Leu Met Ser 
    1430                 1435                 1440             


Lys Ile  Leu Gln Ser Ile Ala  Asn His Val Leu Phe  Thr Lys Glu 
    1445                 1450                 1455             


Glu His  Met Arg Pro Phe Asn  Asp Phe Val Lys Ser  Asn Phe Asp 
    1460                 1465                 1470             


Ala Ala  Arg Arg Phe Phe Leu  Asp Ile Ala Ser Asp  Cys Pro Thr 
    1475                 1480                 1485             


Ser Asp  Ala Val Asn His Ser  Leu Ser Phe Ile Ser  Asp Gly Asn 
    1490                 1495                 1500             


Val Leu  Ala Leu His Arg Leu  Leu Trp Asn Asn Gln  Glu Lys Ile 
    1505                 1510                 1515             


Gly Gln  Tyr Leu Ser Ser Asn  Arg Asp His Lys Ala  Val Gly Arg 
    1520                 1525                 1530             


Arg Pro  Phe Asp Lys Met Ala  Thr Leu Leu Ala Tyr  Leu Gly Pro 
    1535                 1540                 1545             


Pro Glu  His Lys Pro Val Ala  Asp Thr His Trp Ser  Ser Leu Asn 
    1550                 1555                 1560             


Leu Thr  Ser Ser Lys Phe Glu  Glu Phe Met Thr Arg  His Gln Val 
    1565                 1570                 1575             


His Glu  Lys Glu Glu Phe Lys  Ala Leu Lys Thr Leu  Ser Ile Phe 
    1580                 1585                 1590             


Tyr Gln  Ala Gly Thr Ser Lys  Ala Gly Asn Pro Ile  Phe Tyr Tyr 
    1595                 1600                 1605             


Val Ala  Arg Arg Phe Lys Thr  Gly Gln Ile Asn Gly  Asp Leu Leu 
    1610                 1615                 1620             


Ile Tyr  His Val Leu Leu Thr  Leu Lys Pro Tyr Tyr  Ala Lys Pro 
    1625                 1630                 1635             


Tyr Glu  Ile Val Val Asp Leu  Thr His Thr Gly Pro  Ser Asn Arg 
    1640                 1645                 1650             


Phe Lys  Thr Asp Phe Leu Ser  Lys Trp Phe Val Val  Phe Pro Gly 
    1655                 1660                 1665             


Phe Ala  Tyr Asp Asn Val Ser  Ala Val Tyr Ile Tyr  Asn Cys Asn 
    1670                 1675                 1680             


Ser Trp  Val Arg Glu Tyr Thr  Lys Tyr His Glu Arg  Leu Leu Thr 
    1685                 1690                 1695             


Gly Leu  Lys Gly Ser Lys Arg  Leu Val Phe Ile Asp  Cys Pro Gly 
    1700                 1705                 1710             


Lys Leu  Ala Glu His Ile Glu  His Glu Gln Gln Lys  Leu Pro Ala 
    1715                 1720                 1725             


Ala Thr  Leu Ala Leu Glu Glu  Asp Leu Lys Val Phe  His Asn Ala 
    1730                 1735                 1740             


Leu Lys  Leu Ala His Lys Asp  Thr Lys Val Ser Ile  Lys Val Gly 
    1745                 1750                 1755             


Ser Thr  Ala Val Gln Val Thr  Ser Ala Glu Arg Thr  Lys Val Leu 
    1760                 1765                 1770             


Gly Gln  Ser Val Phe Leu Asn  Asp Ile Tyr Tyr Ala  Ser Glu Ile 
    1775                 1780                 1785             


Glu Glu  Ile Cys Leu Val Asp  Glu Asn Gln Phe Thr  Leu Thr Ile 
    1790                 1795                 1800             


Ala Asn  Gln Gly Thr Pro Leu  Thr Phe Met His Gln  Glu Cys Glu 
    1805                 1810                 1815             


Ala Ile  Val Gln Ser Ile Ile  His Ile Arg Thr Arg  Trp Glu Leu 
    1820                 1825                 1830             


Ser Gln  Pro Asp Ser Ile Pro  Gln His Thr Lys Ile  Arg Pro Lys 
    1835                 1840                 1845             


Asp Val  Pro Gly Thr Leu Leu  Asn Ile Ala Leu Leu  Asn Leu Gly 
    1850                 1855                 1860             


Ser Ser  Asp Pro Ser Leu Arg  Ser Ala Ala Tyr Asn  Leu Leu Cys 
    1865                 1870                 1875             


Ala Leu  Thr Cys Thr Phe Asn  Leu Lys Ile Glu Gly  Gln Leu Leu 
    1880                 1885                 1890             


Glu Thr  Ser Gly Leu Cys Ile  Pro Ala Asn Asn Thr  Leu Phe Ile 
    1895                 1900                 1905             


Val Ser  Ile Ser Lys Thr Leu  Ala Ala Asn Glu Pro  His Leu Thr 
    1910                 1915                 1920             


Leu Glu  Phe Leu Glu Glu Cys  Ile Ser Gly Phe Ser  Lys Ser Ser 
    1925                 1930                 1935             


Ile Glu  Leu Lys His Leu Cys  Leu Glu Tyr Met Thr  Pro Trp Leu 
    1940                 1945                 1950             


Ser Asn  Leu Val Arg Phe Cys  Lys His Asn Asp Asp  Ala Lys Arg 
    1955                 1960                 1965             


Gln Arg  Val Thr Ala Ile Leu  Asp Lys Leu Ile Thr  Met Thr Ile 
    1970                 1975                 1980             


Asn Glu  Lys Gln Met Tyr Pro  Ser Ile Gln Ala Lys  Ile Trp Gly 
    1985                 1990                 1995             


Ser Leu  Gly Gln Ile Thr Asp  Leu Leu Asp Val Val  Leu Asp Ser 
    2000                 2005                 2010             


Phe Ile  Lys Thr Ser Ala Thr  Gly Gly Leu Gly Ser  Ile Lys Ala 
    2015                 2020                 2025             


Glu Val  Met Ala Asp Thr Ala  Val Ala Leu Ala Ser  Gly Asn Val 
    2030                 2035                 2040             


Lys Leu  Val Ser Ser Lys Val  Ile Gly Arg Met Cys  Lys Ile Ile 
    2045                 2050                 2055             


Asp Lys  Thr Cys Leu Ser Pro  Thr Pro Thr Leu Glu  Gln His Leu 
    2060                 2065                 2070             


Met Trp  Asp Asp Ile Ala Ile  Leu Ala Arg Tyr Met  Leu Met Leu 
    2075                 2080                 2085             


Ser Phe  Asn Asn Ser Leu Asp  Val Ala Ala His Leu  Pro Tyr Leu 
    2090                 2095                 2100             


Phe His  Val Val Thr Phe Leu  Val Ala Thr Gly Pro  Leu Ser Leu 
    2105                 2110                 2115             


Arg Ala  Ser Thr His Gly Leu  Val Ile Asn Ile Ile  His Ser Leu 
    2120                 2125                 2130             


Cys Thr  Cys Ser Gln Leu His  Phe Ser Glu Glu Thr  Lys Gln Val 
    2135                 2140                 2145             


Leu Arg  Leu Ser Leu Thr Glu  Phe Ser Leu Pro Lys  Phe Tyr Leu 
    2150                 2155                 2160             


Leu Phe  Gly Ile Ser Lys Val  Lys Ser Ala Ala Val  Ile Ala Phe 
    2165                 2170                 2175             


Arg Ser  Ser Tyr Arg Asp Arg  Ser Phe Ser Pro Gly  Ser Tyr Glu 
    2180                 2185                 2190             


Arg Glu  Thr Phe Ala Leu Thr  Ser Leu Glu Thr Val  Thr Glu Ala 
    2195                 2200                 2205             


Leu Leu  Glu Ile Met Glu Ala  Cys Met Arg Asp Ile  Pro Thr Cys 
    2210                 2215                 2220             


Lys Trp  Leu Asp Gln Trp Thr  Glu Leu Ala Gln Arg  Phe Ala Phe 
    2225                 2230                 2235             


Gln Tyr  Asn Pro Ser Leu Gln  Pro Arg Ala Leu Val  Val Phe Gly 
    2240                 2245                 2250             


Cys Ile  Ser Lys Arg Val Ser  His Gly Gln Ile Lys  Gln Ile Ile 
    2255                 2260                 2265             


Arg Ile  Leu Ser Lys Ala Leu  Glu Ser Cys Leu Lys  Gly Pro Asp 
    2270                 2275                 2280             


Thr Tyr  Asn Ser Gln Val Leu  Ile Glu Ala Thr Val  Ile Ala Leu 
    2285                 2290                 2295             


Thr Lys  Leu Gln Pro Leu Leu  Asn Lys Asp Ser Pro  Leu His Lys 
    2300                 2305                 2310             


Ala Leu  Phe Trp Val Ala Val  Ala Val Leu Gln Leu  Asp Glu Val 
    2315                 2320                 2325             


Asn Leu  Tyr Ser Ala Gly Thr  Ala Leu Leu Glu Gln  Asn Leu His 
    2330                 2335                 2340             


Thr Leu  Asp Ser Leu Arg Ile  Phe Asn Asp Lys Ser  Pro Glu Glu 
    2345                 2350                 2355             


Val Phe  Met Ala Ile Arg Asn  Pro Leu Glu Trp His  Cys Lys Gln 
    2360                 2365                 2370             


Met Asp  His Phe Val Gly Leu  Asn Phe Asn Ser Asn  Phe Asn Phe 
    2375                 2380                 2385             


Ala Leu  Val Gly His Leu Leu  Lys Gly Tyr Arg His  Pro Ser Pro 
    2390                 2395                 2400             


Ala Ile  Val Ala Arg Thr Val  Arg Ile Leu His Thr  Leu Leu Thr 
    2405                 2410                 2415             


Leu Val  Asn Lys His Arg Asn  Cys Asp Lys Phe Glu  Val Asn Thr 
    2420                 2425                 2430             


Gln Ser  Val Ala Tyr Leu Ala  Ala Leu Leu Thr Val  Ser Glu Glu 
    2435                 2440                 2445             


Val Arg  Ser Arg Cys Ser Leu  Lys His Arg Lys Ser  Leu Leu Leu 
    2450                 2455                 2460             


Thr Asp  Ile Ser Met Glu Asn  Val Pro Met Asp Thr  Tyr Pro Ile 
    2465                 2470                 2475             


His His  Gly Asp Pro Ser Tyr  Arg Thr Leu Lys Glu  Thr Gln Pro 
    2480                 2485                 2490             


Trp Ser  Ser Pro Lys Gly Ser  Glu Gly Tyr Leu Ala  Ala Thr Tyr 
    2495                 2500                 2505             


Pro Thr  Val Gly Gln Thr Ser  Pro Arg Ala Arg Lys  Ser Met Ser 
    2510                 2515                 2520             


Leu Asp  Met Gly Gln Pro Ser  Gln Ala Asn Thr Lys  Lys Leu Leu 
    2525                 2530                 2535             


Gly Thr  Arg Lys Ser Phe Asp  His Leu Ile Ser Asp  Thr Lys Ala 
    2540                 2545                 2550             


Pro Lys  Arg Gln Glu Met Glu  Ser Gly Ile Thr Thr  Pro Pro Lys 
    2555                 2560                 2565             


Met Arg  Arg Val Ala Glu Thr  Asp Tyr Glu Met Glu  Thr Gln Arg 
    2570                 2575                 2580             


Ile Ser  Ser Ser Gln Gln His  Pro His Leu Arg Lys  Val Ser Val 
    2585                 2590                 2595             


Ser Glu  Ser Asn Val Leu Leu  Asp Glu Glu Val Leu  Thr Asp Pro 
    2600                 2605                 2610             


Lys Ile  Gln Ala Leu Leu Leu  Thr Val Leu Ala Thr  Leu Val Lys 
    2615                 2620                 2625             


Tyr Thr  Thr Asp Glu Phe Asp  Gln Arg Ile Leu Tyr  Glu Tyr Leu 
    2630                 2635                 2640             


Ala Glu  Ala Ser Val Val Phe  Pro Lys Val Phe Pro  Val Val His 
    2645                 2650                 2655             


Asn Leu  Leu Asp Ser Lys Ile  Asn Thr Leu Leu Ser  Leu Cys Gln 
    2660                 2665                 2670             


Asp Pro  Asn Leu Leu Asn Pro  Ile His Gly Ile Val  Gln Ser Val 
    2675                 2680                 2685             


Val Tyr  His Glu Glu Ser Pro  Pro Gln Tyr Gln Thr  Ser Tyr Leu 
    2690                 2695                 2700             


Gln Ser  Phe Gly Phe Asn Gly  Leu Trp Arg Phe Ala  Gly Pro Phe 
    2705                 2710                 2715             


Ser Lys  Gln Thr Gln Ile Pro  Asp Tyr Ala Glu Leu  Ile Val Lys 
    2720                 2725                 2730             


Phe Leu  Asp Ala Leu Ile Asp  Thr Tyr Leu Pro Gly  Ile Asp Glu 
    2735                 2740                 2745             


Glu Thr  Ser Glu Glu Ser Leu  Leu Thr Pro Thr Ser  Pro Tyr Pro 
    2750                 2755                 2760             


Pro Ala  Leu Gln Ser Gln Leu  Ser Ile Thr Ala Asn  Leu Asn Leu 
    2765                 2770                 2775             


Ser Asn  Ser Met Thr Ser Leu  Ala Thr Ser Gln His  Ser Pro Gly 
    2780                 2785                 2790             


Ile Asp  Lys Glu Asn Val Glu  Leu Ser Pro Thr Thr  Gly His Cys 
    2795                 2800                 2805             


Asn Ser  Gly Arg Thr Arg His  Gly Ser Ala Ser Gln  Val Gln Lys 
    2810                 2815                 2820             


Gln Arg  Ser Ala Gly Ser Phe  Lys Arg Asn Ser Ile  Lys Lys Ile 
    2825                 2830                 2835             


Val 
    


<210> 52
<211> 2818
<212> PRT
<213> Homo sapiens

<400> 52
Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu 
545                 550                 555                 560 


Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Ser Ser Gln 
                565                 570                 575     


Met Leu Phe Tyr Ile Cys Lys Lys Leu Thr Ser His Gln Met Leu Ser 
            580                 585                 590         


Ser Thr Glu Ile Leu Lys Trp Leu Arg Glu Ile Leu Ile Cys Arg Asn 
        595                 600                 605             


Lys Phe Leu Leu Lys Asn Lys Gln Ala Asp Arg Ser Ser Cys His Phe 
    610                 615                 620                 


Leu Leu Phe Tyr Gly Val Gly Cys Asp Ile Pro Ser Ser Gly Asn Thr 
625                 630                 635                 640 


Ser Gln Met Ser Met Asp His Glu Glu Leu Leu Arg Thr Pro Gly Ala 
                645                 650                 655     


Ser Leu Arg Lys Gly Lys Gly Asn Ser Ser Met Asp Ser Ala Ala Gly 
            660                 665                 670         


Cys Ser Gly Thr Pro Pro Ile Cys Arg Gln Ala Gln Thr Lys Leu Glu 
        675                 680                 685             


Val Ala Leu Tyr Met Phe Leu Trp Asn Pro Asp Thr Glu Ala Val Leu 
    690                 695                 700                 


Val Ala Met Ser Cys Phe Arg His Leu Cys Glu Glu Ala Asp Ile Arg 
705                 710                 715                 720 


Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn Tyr Asn 
                725                 730                 735     


Thr Phe Met Glu Phe Ala Ser Val Ser Asn Met Met Ser Thr Gly Arg 
            740                 745                 750         


Ala Ala Leu Gln Lys Arg Val Met Ala Leu Leu Arg Arg Ile Glu His 
        755                 760                 765             


Pro Thr Ala Gly Asn Thr Glu Ala Trp Glu Asp Thr His Ala Lys Trp 
    770                 775                 780                 


Glu Gln Ala Thr Lys Leu Ile Leu Asn Tyr Pro Lys Ala Lys Met Glu 
785                 790                 795                 800 


Asp Gly Gln Ala Ala Glu Ser Leu His Lys Thr Ile Val Lys Arg Arg 
                805                 810                 815     


Met Ser His Val Ser Gly Gly Gly Ser Ile Asp Leu Ser Asp Thr Asp 
            820                 825                 830         


Ser Leu Gln Glu Trp Ile Asn Met Thr Gly Phe Leu Cys Ala Leu Gly 
        835                 840                 845             


Gly Val Cys Leu Gln Gln Arg Ser Asn Ser Gly Leu Ala Thr Tyr Ser 
    850                 855                 860                 


Pro Pro Met Gly Pro Val Ser Glu Arg Lys Gly Ser Met Ile Ser Val 
865                 870                 875                 880 


Met Ser Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Phe Met Asp 
                885                 890                 895     


Arg Leu Leu Ser Leu Met Val Cys Asn His Glu Lys Val Gly Leu Gln 
            900                 905                 910         


Ile Arg Thr Asn Val Lys Asp Leu Val Gly Leu Glu Leu Ser Pro Ala 
        915                 920                 925             


Leu Tyr Pro Met Leu Phe Asn Lys Leu Lys Asn Thr Ile Ser Lys Phe 
    930                 935                 940                 


Phe Asp Ser Gln Gly Gln Val Leu Leu Thr Asp Thr Asn Thr Gln Phe 
945                 950                 955                 960 


Val Glu Gln Thr Ile Ala Ile Met Lys Asn Leu Leu Asp Asn His Thr 
                965                 970                 975     


Glu Gly Ser Ser Glu His Leu Gly Gln Ala Ser Ile Glu Thr Met Met 
            980                 985                 990         


Leu Asn Leu Val Arg Tyr Val Arg  Val Leu Gly Asn Met  Val His Ala 
        995                 1000                 1005             


Ile Gln  Ile Lys Thr Lys Leu  Cys Gln Leu Val Glu  Val Met Met 
    1010                 1015                 1020             


Ala Arg  Arg Asp Asp Leu Ser  Phe Cys Gln Glu Met  Lys Phe Arg 
    1025                 1030                 1035             


Asn Lys  Met Val Glu Tyr Leu  Thr Asp Trp Val Met  Gly Thr Ser 
    1040                 1045                 1050             


Asn Gln  Ala Ala Asp Asp Asp  Val Lys Cys Leu Thr  Arg Asp Leu 
    1055                 1060                 1065             


Asp Gln  Ala Ser Met Glu Ala  Val Val Ser Leu Leu  Ala Gly Leu 
    1070                 1075                 1080             


Pro Leu  Gln Pro Glu Glu Gly  Asp Gly Val Glu Leu  Met Glu Ala 
    1085                 1090                 1095             


Lys Ser  Gln Leu Phe Leu Lys  Tyr Phe Thr Leu Phe  Met Asn Leu 
    1100                 1105                 1110             


Leu Asn  Asp Cys Ser Glu Val  Glu Asp Glu Ser Ala  Gln Thr Gly 
    1115                 1120                 1125             


Gly Arg  Lys Arg Gly Met Ser  Arg Arg Leu Ala Ser  Leu Arg His 
    1130                 1135                 1140             


Cys Thr  Val Leu Ala Met Ser  Asn Leu Leu Asn Ala  Asn Val Asp 
    1145                 1150                 1155             


Ser Gly  Leu Met His Ser Ile  Gly Leu Gly Tyr His  Lys Asp Leu 
    1160                 1165                 1170             


Gln Thr  Arg Ala Thr Phe Met  Glu Val Leu Thr Lys  Ile Leu Gln 
    1175                 1180                 1185             


Gln Gly  Thr Glu Phe Asp Thr  Leu Ala Glu Thr Val  Leu Ala Asp 
    1190                 1195                 1200             


Arg Phe  Glu Arg Leu Val Glu  Leu Val Thr Met Met  Gly Asp Gln 
    1205                 1210                 1215             


Gly Glu  Leu Pro Ile Ala Met  Ala Leu Ala Asn Val  Val Pro Cys 
    1220                 1225                 1230             


Ser Gln  Trp Asp Glu Leu Ala  Arg Val Leu Val Thr  Leu Phe Asp 
    1235                 1240                 1245             


Ser Arg  His Leu Leu Tyr Gln  Leu Leu Trp Asn Met  Phe Ser Lys 
    1250                 1255                 1260             


Glu Val  Glu Leu Ala Asp Ser  Met Gln Thr Leu Phe  Arg Gly Asn 
    1265                 1270                 1275             


Ser Leu  Ala Ser Lys Ile Met  Thr Phe Cys Phe Lys  Val Tyr Gly 
    1280                 1285                 1290             


Ala Thr  Tyr Leu Gln Lys Leu  Leu Asp Pro Leu Leu  Arg Ile Val 
    1295                 1300                 1305             


Ile Thr  Ser Ser Asp Trp Gln  His Val Ser Phe Glu  Val Asp Pro 
    1310                 1315                 1320             


Thr Arg  Leu Glu Pro Ser Glu  Ser Leu Glu Glu Asn  Gln Arg Asn 
    1325                 1330                 1335             


Leu Leu  Gln Met Thr Glu Lys  Phe Phe His Ala Ile  Ile Ser Ser 
    1340                 1345                 1350             


Ser Ser  Glu Phe Pro Pro Gln  Leu Arg Ser Val Cys  His Cys Leu 
    1355                 1360                 1365             


Tyr Gln  Val Val Ser Gln Arg  Phe Pro Gln Asn Ser  Ile Gly Ala 
    1370                 1375                 1380             


Val Gly  Ser Ala Met Phe Leu  Arg Phe Ile Asn Pro  Ala Ile Val 
    1385                 1390                 1395             


Ser Pro  Tyr Glu Ala Gly Ile  Leu Asp Lys Lys Pro  Pro Pro Arg 
    1400                 1405                 1410             


Ile Glu  Arg Gly Leu Lys Leu  Met Ser Lys Ile Leu  Gln Ser Ile 
    1415                 1420                 1425             


Ala Asn  His Val Leu Phe Thr  Lys Glu Glu His Met  Arg Pro Phe 
    1430                 1435                 1440             


Asn Asp  Phe Val Lys Ser Asn  Phe Asp Ala Ala Arg  Arg Phe Phe 
    1445                 1450                 1455             


Leu Asp  Ile Ala Ser Asp Cys  Pro Thr Ser Asp Ala  Val Asn His 
    1460                 1465                 1470             


Ser Leu  Ser Phe Ile Ser Asp  Gly Asn Val Leu Ala  Leu His Arg 
    1475                 1480                 1485             


Leu Leu  Trp Asn Asn Gln Glu  Lys Ile Gly Gln Tyr  Leu Ser Ser 
    1490                 1495                 1500             


Asn Arg  Asp His Lys Ala Val  Gly Arg Arg Pro Phe  Asp Lys Met 
    1505                 1510                 1515             


Ala Thr  Leu Leu Ala Tyr Leu  Gly Pro Pro Glu His  Lys Pro Val 
    1520                 1525                 1530             


Ala Asp  Thr His Trp Ser Ser  Leu Asn Leu Thr Ser  Ser Lys Phe 
    1535                 1540                 1545             


Glu Glu  Phe Met Thr Arg His  Gln Val His Glu Lys  Glu Glu Phe 
    1550                 1555                 1560             


Lys Ala  Leu Lys Thr Leu Ser  Ile Phe Tyr Gln Ala  Gly Thr Ser 
    1565                 1570                 1575             


Lys Ala  Gly Asn Pro Ile Phe  Tyr Tyr Val Ala Arg  Arg Phe Lys 
    1580                 1585                 1590             


Thr Gly  Gln Ile Asn Gly Asp  Leu Leu Ile Tyr His  Val Leu Leu 
    1595                 1600                 1605             


Thr Leu  Lys Pro Tyr Tyr Ala  Lys Pro Tyr Glu Ile  Val Val Asp 
    1610                 1615                 1620             


Leu Thr  His Thr Gly Pro Ser  Asn Arg Phe Lys Thr  Asp Phe Leu 
    1625                 1630                 1635             


Ser Lys  Trp Phe Val Val Phe  Pro Gly Phe Ala Tyr  Asp Asn Val 
    1640                 1645                 1650             


Ser Ala  Val Tyr Ile Tyr Asn  Cys Asn Ser Trp Val  Arg Glu Tyr 
    1655                 1660                 1665             


Thr Lys  Tyr His Glu Arg Leu  Leu Thr Gly Leu Lys  Gly Ser Lys 
    1670                 1675                 1680             


Arg Leu  Val Phe Ile Asp Cys  Pro Gly Lys Leu Ala  Glu His Ile 
    1685                 1690                 1695             


Glu His  Glu Gln Gln Lys Leu  Pro Ala Ala Thr Leu  Ala Leu Glu 
    1700                 1705                 1710             


Glu Asp  Leu Lys Val Phe His  Asn Ala Leu Lys Leu  Ala His Lys 
    1715                 1720                 1725             


Asp Thr  Lys Val Ser Ile Lys  Val Gly Ser Thr Ala  Val Gln Val 
    1730                 1735                 1740             


Thr Ser  Ala Glu Arg Thr Lys  Val Leu Gly Gln Ser  Val Phe Leu 
    1745                 1750                 1755             


Asn Asp  Ile Tyr Tyr Ala Ser  Glu Ile Glu Glu Ile  Cys Leu Val 
    1760                 1765                 1770             


Asp Glu  Asn Gln Phe Thr Leu  Thr Ile Ala Asn Gln  Gly Thr Pro 
    1775                 1780                 1785             


Leu Thr  Phe Met His Gln Glu  Cys Glu Ala Ile Val  Gln Ser Ile 
    1790                 1795                 1800             


Ile His  Ile Arg Thr Arg Trp  Glu Leu Ser Gln Pro  Asp Ser Ile 
    1805                 1810                 1815             


Pro Gln  His Thr Lys Ile Arg  Pro Lys Asp Val Pro  Gly Thr Leu 
    1820                 1825                 1830             


Leu Asn  Ile Ala Leu Leu Asn  Leu Gly Ser Ser Asp  Pro Ser Leu 
    1835                 1840                 1845             


Arg Ser  Ala Ala Tyr Asn Leu  Leu Cys Ala Leu Thr  Cys Thr Phe 
    1850                 1855                 1860             


Asn Leu  Lys Ile Glu Gly Gln  Leu Leu Glu Thr Ser  Gly Leu Cys 
    1865                 1870                 1875             


Ile Pro  Ala Asn Asn Thr Leu  Phe Ile Val Ser Ile  Ser Lys Thr 
    1880                 1885                 1890             


Leu Ala  Ala Asn Glu Pro His  Leu Thr Leu Glu Phe  Leu Glu Glu 
    1895                 1900                 1905             


Cys Ile  Ser Gly Phe Ser Lys  Ser Ser Ile Glu Leu  Lys His Leu 
    1910                 1915                 1920             


Cys Leu  Glu Tyr Met Thr Pro  Trp Leu Ser Asn Leu  Val Arg Phe 
    1925                 1930                 1935             


Cys Lys  His Asn Asp Asp Ala  Lys Arg Gln Arg Val  Thr Ala Ile 
    1940                 1945                 1950             


Leu Asp  Lys Leu Ile Thr Met  Thr Ile Asn Glu Lys  Gln Met Tyr 
    1955                 1960                 1965             


Pro Ser  Ile Gln Ala Lys Ile  Trp Gly Ser Leu Gly  Gln Ile Thr 
    1970                 1975                 1980             


Asp Leu  Leu Asp Val Val Leu  Asp Ser Phe Ile Lys  Thr Ser Ala 
    1985                 1990                 1995             


Thr Gly  Gly Leu Gly Ser Ile  Lys Ala Glu Val Met  Ala Asp Thr 
    2000                 2005                 2010             


Ala Val  Ala Leu Ala Ser Gly  Asn Val Lys Leu Val  Ser Ser Lys 
    2015                 2020                 2025             


Val Ile  Gly Arg Met Cys Lys  Ile Ile Asp Lys Thr  Cys Leu Ser 
    2030                 2035                 2040             


Pro Thr  Pro Thr Leu Glu Gln  His Leu Met Trp Asp  Asp Ile Ala 
    2045                 2050                 2055             


Ile Leu  Ala Arg Tyr Met Leu  Met Leu Ser Phe Asn  Asn Ser Leu 
    2060                 2065                 2070             


Asp Val  Ala Ala His Leu Pro  Tyr Leu Phe His Val  Val Thr Phe 
    2075                 2080                 2085             


Leu Val  Ala Thr Gly Pro Leu  Ser Leu Arg Ala Ser  Thr His Gly 
    2090                 2095                 2100             


Leu Val  Ile Asn Ile Ile His  Ser Leu Cys Thr Cys  Ser Gln Leu 
    2105                 2110                 2115             


His Phe  Ser Glu Glu Thr Lys  Gln Val Leu Arg Leu  Ser Leu Thr 
    2120                 2125                 2130             


Glu Phe  Ser Leu Pro Lys Phe  Tyr Leu Leu Phe Gly  Ile Ser Lys 
    2135                 2140                 2145             


Val Lys  Ser Ala Ala Val Ile  Ala Phe Arg Ser Ser  Tyr Arg Asp 
    2150                 2155                 2160             


Arg Ser  Phe Ser Pro Gly Ser  Tyr Glu Arg Glu Thr  Phe Ala Leu 
    2165                 2170                 2175             


Thr Ser  Leu Glu Thr Val Thr  Glu Ala Leu Leu Glu  Ile Met Glu 
    2180                 2185                 2190             


Ala Cys  Met Arg Asp Ile Pro  Thr Cys Lys Trp Leu  Asp Gln Trp 
    2195                 2200                 2205             


Thr Glu  Leu Ala Gln Arg Phe  Ala Phe Gln Tyr Asn  Pro Ser Leu 
    2210                 2215                 2220             


Gln Pro  Arg Ala Leu Val Val  Phe Gly Cys Ile Ser  Lys Arg Val 
    2225                 2230                 2235             


Ser His  Gly Gln Ile Lys Gln  Ile Ile Arg Ile Leu  Ser Lys Ala 
    2240                 2245                 2250             


Leu Glu  Ser Cys Leu Lys Gly  Pro Asp Thr Tyr Asn  Ser Gln Val 
    2255                 2260                 2265             


Leu Ile  Glu Ala Thr Val Ile  Ala Leu Thr Lys Leu  Gln Pro Leu 
    2270                 2275                 2280             


Leu Asn  Lys Asp Ser Pro Leu  His Lys Ala Leu Phe  Trp Val Ala 
    2285                 2290                 2295             


Val Ala  Val Leu Gln Leu Asp  Glu Val Asn Leu Tyr  Ser Ala Gly 
    2300                 2305                 2310             


Thr Ala  Leu Leu Glu Gln Asn  Leu His Thr Leu Asp  Ser Leu Arg 
    2315                 2320                 2325             


Ile Phe  Asn Asp Lys Ser Pro  Glu Glu Val Phe Met  Ala Ile Arg 
    2330                 2335                 2340             


Asn Pro  Leu Glu Trp His Cys  Lys Gln Met Asp His  Phe Val Gly 
    2345                 2350                 2355             


Leu Asn  Phe Asn Ser Asn Phe  Asn Phe Ala Leu Val  Gly His Leu 
    2360                 2365                 2370             


Leu Lys  Gly Tyr Arg His Pro  Ser Pro Ala Ile Val  Ala Arg Thr 
    2375                 2380                 2385             


Val Arg  Ile Leu His Thr Leu  Leu Thr Leu Val Asn  Lys His Arg 
    2390                 2395                 2400             


Asn Cys  Asp Lys Phe Glu Val  Asn Thr Gln Ser Val  Ala Tyr Leu 
    2405                 2410                 2415             


Ala Ala  Leu Leu Thr Val Ser  Glu Glu Val Arg Ser  Arg Cys Ser 
    2420                 2425                 2430             


Leu Lys  His Arg Lys Ser Leu  Leu Leu Thr Asp Ile  Ser Met Glu 
    2435                 2440                 2445             


Asn Val  Pro Met Asp Thr Tyr  Pro Ile His His Gly  Asp Pro Ser 
    2450                 2455                 2460             


Tyr Arg  Thr Leu Lys Glu Thr  Gln Pro Trp Ser Ser  Pro Lys Gly 
    2465                 2470                 2475             


Ser Glu  Gly Tyr Leu Ala Ala  Thr Tyr Pro Thr Val  Gly Gln Thr 
    2480                 2485                 2490             


Ser Pro  Arg Ala Arg Lys Ser  Met Ser Leu Asp Met  Gly Gln Pro 
    2495                 2500                 2505             


Ser Gln  Ala Asn Thr Lys Lys  Leu Leu Gly Thr Arg  Lys Ser Phe 
    2510                 2515                 2520             


Asp His  Leu Ile Ser Asp Thr  Lys Ala Pro Lys Arg  Gln Glu Met 
    2525                 2530                 2535             


Glu Ser  Gly Ile Thr Thr Pro  Pro Lys Met Arg Arg  Val Ala Glu 
    2540                 2545                 2550             


Thr Asp  Tyr Glu Met Glu Thr  Gln Arg Ile Ser Ser  Ser Gln Gln 
    2555                 2560                 2565             


His Pro  His Leu Arg Lys Val  Ser Val Ser Glu Ser  Asn Val Leu 
    2570                 2575                 2580             


Leu Asp  Glu Glu Val Leu Thr  Asp Pro Lys Ile Gln  Ala Leu Leu 
    2585                 2590                 2595             


Leu Thr  Val Leu Ala Thr Leu  Val Lys Tyr Thr Thr  Asp Glu Phe 
    2600                 2605                 2610             


Asp Gln  Arg Ile Leu Tyr Glu  Tyr Leu Ala Glu Ala  Ser Val Val 
    2615                 2620                 2625             


Phe Pro  Lys Val Phe Pro Val  Val His Asn Leu Leu  Asp Ser Lys 
    2630                 2635                 2640             


Ile Asn  Thr Leu Leu Ser Leu  Cys Gln Asp Pro Asn  Leu Leu Asn 
    2645                 2650                 2655             


Pro Ile  His Gly Ile Val Gln  Ser Val Val Tyr His  Glu Glu Ser 
    2660                 2665                 2670             


Pro Pro  Gln Tyr Gln Thr Ser  Tyr Leu Gln Ser Phe  Gly Phe Asn 
    2675                 2680                 2685             


Gly Leu  Trp Arg Phe Ala Gly  Pro Phe Ser Lys Gln  Thr Gln Ile 
    2690                 2695                 2700             


Pro Asp  Tyr Ala Glu Leu Ile  Val Lys Phe Leu Asp  Ala Leu Ile 
    2705                 2710                 2715             


Asp Thr  Tyr Leu Pro Gly Ile  Asp Glu Glu Thr Ser  Glu Glu Ser 
    2720                 2725                 2730             


Leu Leu  Thr Pro Thr Ser Pro  Tyr Pro Pro Ala Leu  Gln Ser Gln 
    2735                 2740                 2745             


Leu Ser  Ile Thr Ala Asn Leu  Asn Leu Ser Asn Ser  Met Thr Ser 
    2750                 2755                 2760             


Leu Ala  Thr Ser Gln His Ser  Pro Gly Ile Asp Lys  Glu Asn Val 
    2765                 2770                 2775             


Glu Leu  Ser Pro Thr Thr Gly  His Cys Asn Ser Gly  Arg Thr Arg 
    2780                 2785                 2790             


His Gly  Ser Ala Ser Gln Val  Gln Lys Gln Arg Ser  Ala Gly Ser 
    2795                 2800                 2805             


Phe Lys  Arg Asn Ser Ile Lys  Lys Ile Val 
    2810                 2815             


<210> 53
<211> 551
<212> PRT
<213> Homo sapiens

<400> 53
Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Val Arg Gly Lys 
545                 550     


<210> 54
<211> 1598
<212> PRT
<213> Homo sapiens

<400> 54
Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu 
545                 550                 555                 560 


Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Ser Ser Gln 
                565                 570                 575     


Met Leu Phe Tyr Ile Cys Lys Lys Leu Thr Ser His Gln Met Leu Ser 
            580                 585                 590         


Ser Thr Glu Ile Leu Lys Trp Leu Arg Glu Ile Leu Ile Cys Arg Asn 
        595                 600                 605             


Lys Phe Leu Leu Lys Asn Lys Gln Ala Asp Arg Ser Ser Cys His Phe 
    610                 615                 620                 


Leu Leu Phe Tyr Gly Val Gly Cys Asp Ile Pro Ser Ser Gly Asn Thr 
625                 630                 635                 640 


Ser Gln Met Ser Met Asp His Glu Glu Leu Leu Arg Thr Pro Gly Ala 
                645                 650                 655     


Ser Leu Arg Lys Gly Lys Gly Asn Ser Ser Met Asp Ser Ala Ala Gly 
            660                 665                 670         


Cys Ser Gly Thr Pro Pro Ile Cys Arg Gln Ala Gln Thr Lys Leu Glu 
        675                 680                 685             


Val Ala Leu Tyr Met Phe Leu Trp Asn Pro Asp Thr Glu Ala Val Leu 
    690                 695                 700                 


Val Ala Met Ser Cys Phe Arg His Leu Cys Glu Glu Ala Asp Ile Arg 
705                 710                 715                 720 


Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn Tyr Asn 
                725                 730                 735     


Thr Phe Met Glu Phe Ala Ser Val Ser Asn Met Met Ser Thr Gly Arg 
            740                 745                 750         


Ala Ala Leu Gln Lys Arg Val Met Ala Leu Leu Arg Arg Ile Glu His 
        755                 760                 765             


Pro Thr Ala Gly Asn Thr Glu Ala Trp Glu Asp Thr His Ala Lys Trp 
    770                 775                 780                 


Glu Gln Ala Thr Lys Leu Ile Leu Asn Tyr Pro Lys Ala Lys Met Glu 
785                 790                 795                 800 


Asp Gly Gln Ala Ala Glu Ser Leu His Lys Thr Ile Val Lys Arg Arg 
                805                 810                 815     


Met Ser His Val Ser Gly Gly Gly Ser Ile Asp Leu Ser Asp Thr Asp 
            820                 825                 830         


Ser Leu Gln Glu Trp Ile Asn Met Thr Gly Phe Leu Cys Ala Leu Gly 
        835                 840                 845             


Gly Val Cys Leu Gln Gln Arg Ser Asn Ser Gly Leu Ala Thr Tyr Ser 
    850                 855                 860                 


Pro Pro Met Gly Pro Val Ser Glu Arg Lys Gly Ser Met Ile Ser Val 
865                 870                 875                 880 


Met Ser Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Phe Met Asp 
                885                 890                 895     


Arg Leu Leu Ser Leu Met Val Cys Asn His Glu Lys Val Gly Leu Gln 
            900                 905                 910         


Ile Arg Thr Asn Val Lys Asp Leu Val Gly Leu Glu Leu Ser Pro Ala 
        915                 920                 925             


Leu Tyr Pro Met Leu Phe Asn Lys Leu Lys Asn Thr Ile Ser Lys Phe 
    930                 935                 940                 


Phe Asp Ser Gln Gly Gln Val Leu Leu Thr Asp Thr Asn Thr Gln Phe 
945                 950                 955                 960 


Val Glu Gln Thr Ile Ala Ile Met Lys Asn Leu Leu Asp Asn His Thr 
                965                 970                 975     


Glu Gly Ser Ser Glu His Leu Gly Gln Ala Ser Ile Glu Thr Met Met 
            980                 985                 990         


Leu Asn Leu Val Arg Tyr Val Arg  Val Leu Gly Asn Met  Val His Ala 
        995                 1000                 1005             


Ile Gln  Ile Lys Thr Lys Leu  Cys Gln Leu Val Glu  Val Met Met 
    1010                 1015                 1020             


Ala Arg  Arg Asp Asp Leu Ser  Phe Cys Gln Glu Met  Lys Phe Arg 
    1025                 1030                 1035             


Asn Lys  Met Val Glu Tyr Leu  Thr Asp Trp Val Met  Gly Thr Ser 
    1040                 1045                 1050             


Asn Gln  Ala Ala Asp Asp Asp  Val Lys Cys Leu Thr  Arg Asp Leu 
    1055                 1060                 1065             


Asp Gln  Ala Ser Met Glu Ala  Val Val Ser Leu Leu  Ala Gly Leu 
    1070                 1075                 1080             


Pro Leu  Gln Pro Glu Glu Gly  Asp Gly Val Glu Leu  Met Glu Ala 
    1085                 1090                 1095             


Lys Ser  Gln Leu Phe Leu Lys  Tyr Phe Thr Leu Phe  Met Asn Leu 
    1100                 1105                 1110             


Leu Asn  Asp Cys Ser Glu Val  Glu Asp Glu Ser Ala  Gln Thr Gly 
    1115                 1120                 1125             


Gly Arg  Lys Arg Gly Met Ser  Arg Arg Leu Ala Ser  Leu Arg His 
    1130                 1135                 1140             


Cys Thr  Val Leu Ala Met Ser  Asn Leu Leu Asn Ala  Asn Val Asp 
    1145                 1150                 1155             


Ser Gly  Leu Met His Ser Ile  Gly Leu Gly Tyr His  Lys Asp Leu 
    1160                 1165                 1170             


Gln Thr  Arg Ala Thr Phe Met  Glu Val Leu Thr Lys  Ile Leu Gln 
    1175                 1180                 1185             


Gln Gly  Thr Glu Phe Asp Thr  Leu Ala Glu Thr Val  Leu Ala Asp 
    1190                 1195                 1200             


Arg Phe  Glu Arg Leu Val Glu  Leu Val Thr Met Met  Gly Asp Gln 
    1205                 1210                 1215             


Gly Glu  Leu Pro Ile Ala Met  Ala Leu Ala Asn Val  Val Pro Cys 
    1220                 1225                 1230             


Ser Gln  Trp Asp Glu Leu Ala  Arg Val Leu Val Thr  Leu Phe Asp 
    1235                 1240                 1245             


Ser Arg  His Leu Leu Tyr Gln  Leu Leu Trp Asn Met  Phe Ser Lys 
    1250                 1255                 1260             


Glu Val  Glu Leu Ala Asp Ser  Met Gln Thr Leu Phe  Arg Gly Asn 
    1265                 1270                 1275             


Ser Leu  Ala Ser Lys Ile Met  Thr Phe Cys Phe Lys  Val Tyr Gly 
    1280                 1285                 1290             


Ala Thr  Tyr Leu Gln Lys Leu  Leu Asp Pro Leu Leu  Arg Ile Val 
    1295                 1300                 1305             


Ile Thr  Ser Ser Asp Trp Gln  His Val Ser Phe Glu  Val Asp Pro 
    1310                 1315                 1320             


Thr Arg  Leu Glu Pro Ser Glu  Ser Leu Glu Glu Asn  Gln Arg Asn 
    1325                 1330                 1335             


Leu Leu  Gln Met Thr Glu Lys  Phe Phe His Ala Ile  Ile Ser Ser 
    1340                 1345                 1350             


Ser Ser  Glu Phe Pro Pro Gln  Leu Arg Ser Val Cys  His Cys Leu 
    1355                 1360                 1365             


Tyr Gln  Ala Thr Cys His Ser  Leu Leu Asn Lys Ala  Thr Val Lys 
    1370                 1375                 1380             


Glu Lys  Lys Glu Asn Lys Lys  Ser Val Val Ser Gln  Arg Phe Pro 
    1385                 1390                 1395             


Gln Asn  Ser Ile Gly Ala Val  Gly Ser Ala Met Phe  Leu Arg Phe 
    1400                 1405                 1410             


Ile Asn  Pro Ala Ile Val Ser  Pro Tyr Glu Ala Gly  Ile Leu Asp 
    1415                 1420                 1425             


Lys Lys  Pro Pro Pro Arg Ile  Glu Arg Gly Leu Lys  Leu Met Ser 
    1430                 1435                 1440             


Lys Ile  Leu Gln Ser Ile Ala  Asn His Val Leu Phe  Thr Lys Glu 
    1445                 1450                 1455             


Glu His  Met Arg Pro Phe Asn  Asp Phe Val Lys Ser  Asn Phe Asp 
    1460                 1465                 1470             


Ala Ala  Arg Arg Phe Phe Leu  Asp Ile Ala Ser Asp  Cys Pro Thr 
    1475                 1480                 1485             


Ser Asp  Ala Val Asn His Ser  Leu Ser Phe Ile Ser  Asp Gly Asn 
    1490                 1495                 1500             


Val Leu  Ala Leu His Arg Leu  Leu Trp Asn Asn Gln  Glu Lys Ile 
    1505                 1510                 1515             


Gly Gln  Tyr Leu Ser Ser Asn  Arg Asp His Lys Ala  Val Gly Arg 
    1520                 1525                 1530             


Arg Pro  Phe Asp Lys Met Ala  Thr Leu Leu Ala Tyr  Leu Gly Pro 
    1535                 1540                 1545             


Pro Glu  His Lys Pro Val Ala  Asp Thr His Trp Ser  Ser Leu Asn 
    1550                 1555                 1560             


Leu Thr  Ser Ser Lys Phe Glu  Glu Phe Met Thr Arg  His Gln Val 
    1565                 1570                 1575             


His Glu  Lys Glu Glu Phe Lys  Ala Leu Lys Thr Leu  Thr Pro Pro 
    1580                 1585                 1590             


Pro Glu  Pro Glu Thr 
    1595             


<210> 55
<211> 593
<212> PRT
<213> Homo sapiens

<400> 55
Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu 
545                 550                 555                 560 


Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Arg Tyr Met 
                565                 570                 575     


Tyr Phe Tyr Phe Leu Asn Ser Thr Phe Lys Phe Tyr Phe Val Phe Leu 
            580                 585                 590         


Ser 
    


<210> 56
<211> 2836
<212> PRT
<213> Homo sapiens

<400> 56
Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu 
545                 550                 555                 560 


Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Ser Ser Gln 
                565                 570                 575     


Met Leu Phe Tyr Ile Cys Lys Lys Leu Thr Ser His Gln Met Leu Ser 
            580                 585                 590         


Ser Thr Glu Ile Leu Lys Trp Leu Arg Glu Ile Leu Ile Cys Arg Asn 
        595                 600                 605             


Lys Phe Leu Leu Lys Asn Lys Gln Ala Asp Arg Ser Ser Cys His Phe 
    610                 615                 620                 


Leu Leu Phe Tyr Gly Val Gly Cys Asp Ile Pro Ser Ser Gly Asn Thr 
625                 630                 635                 640 


Ser Gln Met Ser Met Asp His Glu Glu Leu Leu Arg Thr Pro Gly Ala 
                645                 650                 655     


Ser Leu Arg Lys Gly Lys Gly Asn Ser Ser Met Asp Ser Ala Ala Gly 
            660                 665                 670         


Cys Ser Gly Thr Pro Pro Ile Cys Arg Gln Ala Gln Thr Lys Leu Glu 
        675                 680                 685             


Val Ala Leu Tyr Met Phe Leu Trp Asn Pro Asp Thr Glu Ala Val Leu 
    690                 695                 700                 


Val Ala Met Ser Cys Phe Arg His Leu Cys Glu Glu Ala Asp Ile Arg 
705                 710                 715                 720 


Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn Tyr Asn 
                725                 730                 735     


Thr Phe Met Glu Phe Ala Ser Val Ser Asn Met Met Ser Thr Gly Arg 
            740                 745                 750         


Ala Ala Leu Gln Lys Arg Val Met Ala Leu Leu Arg Arg Ile Glu His 
        755                 760                 765             


Pro Thr Ala Gly Asn Thr Glu Ala Trp Glu Asp Thr His Ala Lys Trp 
    770                 775                 780                 


Glu Gln Ala Thr Lys Leu Ile Leu Asn Tyr Pro Lys Ala Lys Met Glu 
785                 790                 795                 800 


Asp Gly Gln Ala Ala Glu Ser Leu His Lys Thr Ile Val Lys Arg Arg 
                805                 810                 815     


Met Ser His Val Ser Gly Gly Gly Ser Ile Asp Leu Ser Asp Thr Asp 
            820                 825                 830         


Ser Leu Gln Glu Trp Ile Asn Met Thr Gly Phe Leu Cys Ala Leu Gly 
        835                 840                 845             


Gly Val Cys Leu Gln Gln Arg Ser Asn Ser Gly Leu Ala Thr Tyr Ser 
    850                 855                 860                 


Pro Pro Met Gly Pro Val Ser Glu Arg Lys Gly Ser Met Ile Ser Val 
865                 870                 875                 880 


Met Ser Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Phe Met Asp 
                885                 890                 895     


Arg Leu Leu Ser Leu Met Val Cys Asn His Glu Lys Val Gly Leu Gln 
            900                 905                 910         


Ile Arg Thr Asn Val Lys Asp Leu Val Gly Leu Glu Leu Ser Pro Ala 
        915                 920                 925             


Leu Tyr Pro Met Leu Phe Asn Lys Leu Lys Asn Thr Ile Ser Lys Phe 
    930                 935                 940                 


Phe Asp Ser Gln Gly Gln Val Leu Leu Thr Asp Thr Asn Thr Gln Phe 
945                 950                 955                 960 


Val Glu Gln Thr Ile Ala Ile Met Lys Asn Leu Leu Asp Asn His Thr 
                965                 970                 975     


Glu Gly Ser Ser Glu His Leu Gly Gln Ala Ser Ile Glu Thr Met Met 
            980                 985                 990         


Leu Asn Leu Val Arg Tyr Val Arg  Val Leu Gly Asn Met  Val His Ala 
        995                 1000                 1005             


Ile Gln  Ile Lys Thr Lys Leu  Cys Gln Leu Val Glu  Val Met Met 
    1010                 1015                 1020             


Ala Arg  Arg Asp Asp Leu Ser  Phe Cys Gln Glu Met  Lys Phe Arg 
    1025                 1030                 1035             


Asn Lys  Met Val Glu Tyr Leu  Thr Asp Trp Val Met  Gly Thr Ser 
    1040                 1045                 1050             


Asn Gln  Ala Ala Asp Asp Asp  Val Lys Cys Leu Thr  Arg Asp Leu 
    1055                 1060                 1065             


Asp Gln  Ala Ser Met Glu Ala  Val Val Ser Leu Leu  Ala Gly Leu 
    1070                 1075                 1080             


Pro Leu  Gln Pro Glu Glu Gly  Asp Gly Val Glu Leu  Met Glu Ala 
    1085                 1090                 1095             


Lys Ser  Gln Leu Phe Leu Lys  Tyr Phe Thr Leu Phe  Met Asn Leu 
    1100                 1105                 1110             


Leu Asn  Asp Cys Ser Glu Val  Glu Asp Glu Ser Ala  Gln Thr Gly 
    1115                 1120                 1125             


Gly Arg  Lys Arg Gly Met Ser  Arg Arg Leu Ala Ser  Leu Arg His 
    1130                 1135                 1140             


Cys Thr  Val Leu Ala Met Ser  Asn Leu Leu Asn Ala  Asn Val Asp 
    1145                 1150                 1155             


Ser Gly  Leu Met His Ser Ile  Gly Leu Gly Tyr His  Lys Asp Leu 
    1160                 1165                 1170             


Gln Thr  Arg Ala Thr Phe Met  Glu Val Leu Thr Lys  Ile Leu Gln 
    1175                 1180                 1185             


Gln Gly  Thr Glu Phe Asp Thr  Leu Ala Glu Thr Val  Leu Ala Asp 
    1190                 1195                 1200             


Arg Phe  Glu Arg Leu Val Glu  Leu Val Thr Met Met  Gly Asp Gln 
    1205                 1210                 1215             


Gly Glu  Leu Pro Ile Ala Met  Ala Leu Ala Asn Val  Val Pro Cys 
    1220                 1225                 1230             


Ser Gln  Trp Asp Glu Leu Ala  Arg Val Leu Val Thr  Leu Phe Asp 
    1235                 1240                 1245             


Ser Arg  His Leu Leu Tyr Gln  Leu Leu Trp Asn Met  Phe Ser Lys 
    1250                 1255                 1260             


Glu Val  Glu Leu Ala Asp Ser  Met Gln Thr Leu Phe  Arg Gly Asn 
    1265                 1270                 1275             


Ser Leu  Ala Ser Lys Ile Met  Thr Phe Cys Phe Lys  Val Tyr Gly 
    1280                 1285                 1290             


Ala Thr  Tyr Leu Gln Lys Leu  Leu Asp Pro Leu Leu  Arg Ile Val 
    1295                 1300                 1305             


Ile Thr  Ser Ser Asp Trp Gln  His Val Ser Phe Glu  Val Asp Pro 
    1310                 1315                 1320             


Thr Arg  Leu Glu Pro Ser Glu  Ser Leu Glu Glu Asn  Gln Arg Asn 
    1325                 1330                 1335             


Leu Leu  Gln Met Thr Glu Lys  Phe Phe His Ala Ile  Ile Ser Ser 
    1340                 1345                 1350             


Ser Ser  Glu Phe Pro Pro Gln  Leu Arg Ser Val Cys  His Cys Leu 
    1355                 1360                 1365             


Tyr Gln  Val Val Ser Gln Arg  Phe Pro Gln Asn Ser  Ile Gly Ala 
    1370                 1375                 1380             


Val Gly  Ser Ala Met Phe Leu  Arg Phe Ile Asn Pro  Ala Ile Val 
    1385                 1390                 1395             


Ser Pro  Tyr Glu Ala Gly Ile  Leu Asp Lys Lys Pro  Pro Pro Arg 
    1400                 1405                 1410             


Ile Glu  Arg Gly Leu Lys Leu  Met Ser Lys Ile Leu  Gln Ser Ile 
    1415                 1420                 1425             


Ala Asn  His Val Leu Phe Thr  Lys Glu Glu His Met  Arg Pro Phe 
    1430                 1435                 1440             


Asn Asp  Phe Val Lys Ser Asn  Phe Asp Ala Ala Arg  Arg Phe Phe 
    1445                 1450                 1455             


Leu Asp  Ile Ala Ser Asp Cys  Pro Thr Ser Asp Ala  Val Asn His 
    1460                 1465                 1470             


Ser Leu  Ser Phe Ile Ser Asp  Gly Asn Val Leu Ala  Leu His Arg 
    1475                 1480                 1485             


Leu Leu  Trp Asn Asn Gln Glu  Lys Ile Gly Gln Tyr  Leu Ser Ser 
    1490                 1495                 1500             


Asn Arg  Asp His Lys Ala Val  Gly Arg Arg Pro Phe  Asp Lys Met 
    1505                 1510                 1515             


Ala Thr  Leu Leu Ala Tyr Leu  Gly Pro Pro Glu His  Lys Pro Val 
    1520                 1525                 1530             


Ala Asp  Thr His Trp Ser Ser  Leu Asn Leu Thr Ser  Ser Lys Phe 
    1535                 1540                 1545             


Glu Glu  Phe Met Thr Arg His  Gln Val His Glu Lys  Glu Glu Phe 
    1550                 1555                 1560             


Lys Ala  Leu Lys Thr Leu Ser  Ile Phe Tyr Gln Ala  Gly Thr Ser 
    1565                 1570                 1575             


Lys Ala  Gly Asn Pro Ile Phe  Tyr Tyr Val Ala Arg  Arg Phe Lys 
    1580                 1585                 1590             


Thr Gly  Gln Ile Asn Gly Asp  Leu Leu Ile Tyr His  Val Leu Leu 
    1595                 1600                 1605             


Thr Leu  Lys Pro Tyr Tyr Ala  Lys Pro Tyr Glu Ile  Val Val Asp 
    1610                 1615                 1620             


Leu Thr  His Thr Gly Pro Ser  Asn Arg Phe Lys Thr  Asp Phe Leu 
    1625                 1630                 1635             


Ser Lys  Trp Phe Val Val Phe  Pro Gly Phe Ala Tyr  Asp Asn Val 
    1640                 1645                 1650             


Ser Ala  Val Tyr Ile Tyr Asn  Cys Asn Ser Trp Val  Arg Glu Tyr 
    1655                 1660                 1665             


Thr Lys  Tyr His Glu Arg Leu  Leu Thr Gly Leu Lys  Gly Ser Lys 
    1670                 1675                 1680             


Arg Leu  Val Phe Ile Asp Cys  Pro Gly Lys Leu Ala  Glu His Ile 
    1685                 1690                 1695             


Glu His  Glu Gln Gln Lys Leu  Pro Ala Ala Thr Leu  Ala Leu Glu 
    1700                 1705                 1710             


Glu Asp  Leu Lys Val Phe His  Asn Ala Leu Lys Leu  Ala His Lys 
    1715                 1720                 1725             


Asp Thr  Lys Val Ser Ile Lys  Val Gly Ser Thr Ala  Val Gln Val 
    1730                 1735                 1740             


Thr Ser  Ala Glu Arg Thr Lys  Val Leu Gly Gln Ser  Val Phe Leu 
    1745                 1750                 1755             


Asn Asp  Ile Tyr Tyr Ala Ser  Glu Ile Glu Glu Ile  Cys Leu Val 
    1760                 1765                 1770             


Asp Glu  Asn Gln Phe Thr Leu  Thr Ile Ala Asn Gln  Gly Thr Pro 
    1775                 1780                 1785             


Leu Thr  Phe Met His Gln Glu  Cys Glu Ala Ile Val  Gln Ser Ile 
    1790                 1795                 1800             


Ile His  Ile Arg Thr Arg Trp  Glu Leu Ser Gln Pro  Asp Ser Ile 
    1805                 1810                 1815             


Pro Gln  His Thr Lys Ile Arg  Pro Lys Asp Val Pro  Gly Thr Leu 
    1820                 1825                 1830             


Leu Asn  Ile Ala Leu Leu Asn  Leu Gly Ser Ser Asp  Pro Ser Leu 
    1835                 1840                 1845             


Arg Ser  Ala Ala Tyr Asn Leu  Leu Cys Ala Leu Thr  Cys Thr Phe 
    1850                 1855                 1860             


Asn Leu  Lys Ile Glu Gly Gln  Leu Leu Glu Thr Ser  Gly Leu Cys 
    1865                 1870                 1875             


Ile Pro  Ala Asn Asn Thr Leu  Phe Ile Val Ser Ile  Ser Lys Thr 
    1880                 1885                 1890             


Leu Ala  Ala Asn Glu Pro His  Leu Thr Leu Glu Phe  Leu Glu Glu 
    1895                 1900                 1905             


Cys Ile  Ser Gly Phe Ser Lys  Ser Ser Ile Glu Leu  Lys His Leu 
    1910                 1915                 1920             


Cys Leu  Glu Tyr Met Thr Pro  Trp Leu Ser Asn Leu  Val Arg Phe 
    1925                 1930                 1935             


Cys Lys  His Asn Asp Asp Ala  Lys Arg Gln Arg Val  Thr Ala Ile 
    1940                 1945                 1950             


Leu Asp  Lys Leu Ile Thr Met  Thr Ile Asn Glu Lys  Gln Met Tyr 
    1955                 1960                 1965             


Pro Ser  Ile Gln Ala Lys Ile  Trp Gly Ser Leu Gly  Gln Ile Thr 
    1970                 1975                 1980             


Asp Leu  Leu Asp Val Val Leu  Asp Ser Phe Ile Lys  Thr Ser Ala 
    1985                 1990                 1995             


Thr Gly  Gly Leu Gly Ser Ile  Lys Ala Glu Val Met  Ala Asp Thr 
    2000                 2005                 2010             


Ala Val  Ala Leu Ala Ser Gly  Asn Val Lys Leu Val  Ser Ser Lys 
    2015                 2020                 2025             


Val Ile  Gly Arg Met Cys Lys  Ile Ile Asp Lys Thr  Cys Leu Ser 
    2030                 2035                 2040             


Pro Thr  Pro Thr Leu Glu Gln  His Leu Met Trp Asp  Asp Ile Ala 
    2045                 2050                 2055             


Ile Leu  Ala Arg Tyr Met Leu  Met Leu Ser Phe Asn  Asn Ser Leu 
    2060                 2065                 2070             


Asp Val  Ala Ala His Leu Pro  Tyr Leu Phe His Val  Val Thr Phe 
    2075                 2080                 2085             


Leu Val  Ala Thr Gly Pro Leu  Ser Leu Arg Ala Ser  Thr His Gly 
    2090                 2095                 2100             


Leu Val  Ile Asn Ile Ile His  Ser Leu Cys Thr Cys  Ser Gln Leu 
    2105                 2110                 2115             


His Phe  Ser Glu Glu Thr Lys  Gln Val Leu Arg Leu  Ser Leu Thr 
    2120                 2125                 2130             


Glu Phe  Ser Leu Pro Lys Phe  Tyr Leu Leu Phe Gly  Ile Ser Lys 
    2135                 2140                 2145             


Val Lys  Ser Ala Ala Val Ile  Ala Phe Arg Ser Ser  Tyr Arg Asp 
    2150                 2155                 2160             


Arg Ser  Phe Ser Pro Gly Ser  Tyr Glu Arg Glu Thr  Phe Ala Leu 
    2165                 2170                 2175             


Thr Ser  Leu Glu Thr Val Thr  Glu Ala Leu Leu Glu  Ile Met Glu 
    2180                 2185                 2190             


Ala Cys  Met Arg Asp Ile Pro  Thr Cys Lys Trp Leu  Asp Gln Trp 
    2195                 2200                 2205             


Thr Glu  Leu Ala Gln Arg Phe  Ala Phe Gln Tyr Asn  Pro Ser Leu 
    2210                 2215                 2220             


Gln Pro  Arg Ala Leu Val Val  Phe Gly Cys Ile Ser  Lys Arg Val 
    2225                 2230                 2235             


Ser His  Gly Gln Ile Lys Gln  Ile Ile Arg Ile Leu  Ser Lys Ala 
    2240                 2245                 2250             


Leu Glu  Ser Cys Leu Lys Gly  Pro Asp Thr Tyr Asn  Ser Gln Val 
    2255                 2260                 2265             


Leu Ile  Glu Ala Thr Val Ile  Ala Leu Thr Lys Leu  Gln Pro Leu 
    2270                 2275                 2280             


Leu Asn  Lys Asp Ser Pro Leu  His Lys Ala Leu Phe  Trp Val Ala 
    2285                 2290                 2295             


Val Ala  Val Leu Gln Leu Asp  Glu Val Asn Leu Tyr  Ser Ala Gly 
    2300                 2305                 2310             


Thr Ala  Leu Leu Glu Gln Asn  Leu His Thr Leu Asp  Ser Leu Arg 
    2315                 2320                 2325             


Ile Phe  Asn Asp Lys Ser Pro  Glu Glu Val Phe Met  Ala Ile Arg 
    2330                 2335                 2340             


Asn Pro  Leu Glu Trp His Cys  Lys Gln Met Asp His  Phe Val Gly 
    2345                 2350                 2355             


Leu Asn  Phe Asn Ser Asn Phe  Asn Phe Ala Leu Val  Gly His Leu 
    2360                 2365                 2370             


Leu Lys  Gly Tyr Arg His Pro  Ser Pro Ala Ile Val  Ala Arg Thr 
    2375                 2380                 2385             


Val Arg  Ile Leu His Thr Leu  Leu Thr Leu Val Asn  Lys His Arg 
    2390                 2395                 2400             


Asn Cys  Asp Lys Phe Glu Val  Asn Thr Gln Ser Val  Ala Tyr Leu 
    2405                 2410                 2415             


Ala Ala  Leu Leu Thr Val Ser  Glu Glu Val Arg Ser  Arg Cys Ser 
    2420                 2425                 2430             


Leu Lys  His Arg Lys Ser Leu  Leu Leu Thr Asp Ile  Ser Met Glu 
    2435                 2440                 2445             


Asn Val  Pro Met Asp Thr Tyr  Pro Ile His His Gly  Asp Pro Ser 
    2450                 2455                 2460             


Tyr Arg  Thr Leu Lys Glu Thr  Gln Pro Trp Ser Ser  Pro Lys Gly 
    2465                 2470                 2475             


Ser Glu  Gly Tyr Leu Ala Ala  Thr Tyr Pro Thr Val  Gly Gln Thr 
    2480                 2485                 2490             


Ser Pro  Arg Ala Arg Lys Ser  Met Ser Leu Asp Met  Gly Gln Pro 
    2495                 2500                 2505             


Ser Gln  Ala Asn Thr Lys Lys  Leu Leu Gly Thr Arg  Lys Ser Phe 
    2510                 2515                 2520             


Asp His  Leu Ile Ser Asp Thr  Lys Ala Pro Lys Arg  Gln Glu Met 
    2525                 2530                 2535             


Glu Ser  Gly Ile Thr Thr Pro  Pro Lys Met Arg Arg  Val Ala Glu 
    2540                 2545                 2550             


Thr Asp  Tyr Glu Met Glu Thr  Gln Arg Ile Ser Ser  Ser Gln Gln 
    2555                 2560                 2565             


His Pro  His Leu Arg Lys Val  Ser Val Ser Glu Ser  Asn Val Leu 
    2570                 2575                 2580             


Leu Asp  Glu Glu Val Leu Thr  Asp Pro Lys Ile Gln  Ala Leu Leu 
    2585                 2590                 2595             


Leu Thr  Val Leu Ala Thr Leu  Val Lys Tyr Thr Thr  Asp Glu Phe 
    2600                 2605                 2610             


Asp Gln  Arg Ile Leu Tyr Glu  Tyr Leu Ala Glu Ala  Ser Val Val 
    2615                 2620                 2625             


Phe Pro  Lys Val Phe Pro Val  Val His Asn Leu Leu  Asp Ser Lys 
    2630                 2635                 2640             


Ile Asn  Thr Leu Leu Ser Leu  Cys Gln Asp Pro Asn  Leu Leu Asn 
    2645                 2650                 2655             


Pro Ile  His Gly Ile Val Gln  Ser Val Val Tyr His  Glu Glu Ser 
    2660                 2665                 2670             


Pro Pro  Gln Tyr Gln Thr Ser  Tyr Leu Gln Ser Phe  Gly Phe Asn 
    2675                 2680                 2685             


Gly Leu  Trp Arg Phe Ala Gly  Pro Phe Ser Lys Gln  Thr Gln Ile 
    2690                 2695                 2700             


Pro Asp  Tyr Ala Glu Leu Ile  Val Lys Phe Leu Asp  Ala Leu Ile 
    2705                 2710                 2715             


Asp Thr  Tyr Leu Pro Gly Ile  Asp Glu Glu Thr Ser  Glu Glu Ser 
    2720                 2725                 2730             


Leu Leu  Thr Pro Thr Ser Pro  Tyr Pro Pro Ala Leu  Gln Ser Gln 
    2735                 2740                 2745             


Leu Ser  Ile Thr Ala Asn Leu  Asn Leu Ser Asn Ser  Met Thr Ser 
    2750                 2755                 2760             


Leu Ala  Thr Ser Gln His Ser  Pro Ala Ser Leu Pro  Cys Ser Asn 
    2765                 2770                 2775             


Ser Ala  Val Phe Met Gln Leu  Phe Pro His Gln Gly  Ile Asp Lys 
    2780                 2785                 2790             


Glu Asn  Val Glu Leu Ser Pro  Thr Thr Gly His Cys  Asn Ser Gly 
    2795                 2800                 2805             


Arg Thr  Arg His Gly Ser Ala  Ser Gln Val Gln Lys  Gln Arg Ser 
    2810                 2815                 2820             


Ala Gly  Ser Phe Lys Arg Asn  Ser Ile Lys Lys Ile  Val 
    2825                 2830                 2835     


<210> 57
<211> 326
<212> PRT
<213> Homo sapiens

<400> 57
Met Glu Lys Asp Gly Leu Cys Arg Ala Asp Gln Gln Tyr Glu Cys Val 
1               5                   10                  15      


Ala Glu Ile Gly Glu Gly Ala Tyr Gly Lys Val Phe Lys Ala Arg Asp 
            20                  25                  30          


Leu Lys Asn Gly Gly Arg Phe Val Ala Leu Lys Arg Val Arg Val Gln 
        35                  40                  45              


Thr Gly Glu Glu Gly Met Pro Leu Ser Thr Ile Arg Glu Val Ala Val 
    50                  55                  60                  


Leu Arg His Leu Glu Thr Phe Glu His Pro Asn Val Val Arg Leu Phe 
65                  70                  75                  80  


Asp Val Cys Thr Val Ser Arg Thr Asp Arg Glu Thr Lys Leu Thr Leu 
                85                  90                  95      


Val Phe Glu His Val Asp Gln Asp Leu Thr Thr Tyr Leu Asp Lys Val 
            100                 105                 110         


Pro Glu Pro Gly Val Pro Thr Glu Thr Ile Lys Asp Met Met Phe Gln 
        115                 120                 125             


Leu Leu Arg Gly Leu Asp Phe Leu His Ser His Arg Val Val His Arg 
    130                 135                 140                 


Asp Leu Lys Pro Gln Asn Ile Leu Val Thr Ser Ser Gly Gln Ile Lys 
145                 150                 155                 160 


Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Phe Gln Met Ala Leu 
                165                 170                 175     


Thr Ser Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu 
            180                 185                 190         


Gln Ser Ser Tyr Ala Thr Pro Val Asp Leu Trp Ser Val Gly Cys Ile 
        195                 200                 205             


Phe Ala Glu Met Phe Arg Arg Lys Pro Leu Phe Arg Gly Ser Ser Asp 
    210                 215                 220                 


Val Asp Gln Leu Gly Lys Ile Leu Asp Val Ile Gly Leu Pro Gly Glu 
225                 230                 235                 240 


Glu Asp Trp Pro Arg Asp Val Ala Leu Pro Arg Gln Ala Phe His Ser 
                245                 250                 255     


Lys Ser Ala Gln Pro Ile Glu Lys Phe Val Thr Asp Ile Asp Glu Leu 
            260                 265                 270         


Gly Lys Asp Leu Leu Leu Lys Cys Leu Thr Phe Asn Pro Ala Lys Arg 
        275                 280                 285             


Ile Ser Ala Tyr Ser Ala Leu Ser His Pro Tyr Phe Gln Asp Leu Glu 
    290                 295                 300                 


Arg Cys Lys Glu Asn Leu Asp Ser His Leu Pro Pro Ser Gln Asn Thr 
305                 310                 315                 320 


Ser Glu Leu Asn Thr Ala 
                325     


<210> 58
<211> 873
<212> PRT
<213> Homo sapiens

<400> 58
Met Gly Thr Ser Ala Leu Trp Ala Leu Trp Leu Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Ala Pro Arg Glu Ser Gly Ala Thr Gly Thr Gly Arg Lys Ala Lys 
            20                  25                  30          


Cys Glu Pro Ser Gln Phe Gln Cys Thr Asn Gly Arg Cys Ile Thr Leu 
        35                  40                  45              


Leu Trp Lys Cys Asp Gly Asp Glu Asp Cys Val Asp Gly Ser Asp Glu 
    50                  55                  60                  


Lys Asn Cys Val Lys Lys Thr Cys Ala Glu Ser Asp Phe Val Cys Asn 
65                  70                  75                  80  


Asn Gly Gln Cys Val Pro Ser Arg Trp Lys Cys Asp Gly Asp Pro Asp 
                85                  90                  95      


Cys Glu Asp Gly Ser Asp Glu Ser Pro Glu Gln Cys His Met Arg Thr 
            100                 105                 110         


Cys Arg Ile His Glu Ile Ser Cys Gly Ala His Ser Thr Gln Cys Ile 
        115                 120                 125             


Pro Val Ser Trp Arg Cys Asp Gly Glu Asn Asp Cys Asp Ser Gly Glu 
    130                 135                 140                 


Asp Glu Glu Asn Cys Gly Asn Ile Thr Cys Ser Pro Asp Glu Phe Thr 
145                 150                 155                 160 


Cys Ser Ser Gly Arg Cys Ile Ser Arg Asn Phe Val Cys Asn Gly Gln 
                165                 170                 175     


Asp Asp Cys Ser Asp Gly Ser Asp Glu Leu Asp Cys Ala Pro Pro Thr 
            180                 185                 190         


Cys Gly Ala His Glu Phe Gln Cys Ser Thr Ser Ser Cys Ile Pro Ile 
        195                 200                 205             


Ser Trp Val Cys Asp Asp Asp Ala Asp Cys Ser Asp Gln Ser Asp Glu 
    210                 215                 220                 


Ser Leu Glu Gln Cys Gly Arg Gln Pro Val Ile His Thr Lys Cys Pro 
225                 230                 235                 240 


Ala Ser Glu Ile Gln Cys Gly Ser Gly Glu Cys Ile His Lys Lys Trp 
                245                 250                 255     


Arg Cys Asp Gly Asp Pro Asp Cys Lys Asp Gly Ser Asp Glu Val Asn 
            260                 265                 270         


Cys Pro Ser Arg Thr Cys Arg Pro Asp Gln Phe Glu Cys Glu Asp Gly 
        275                 280                 285             


Ser Cys Ile His Gly Ser Arg Gln Cys Asn Gly Ile Arg Asp Cys Val 
    290                 295                 300                 


Asp Gly Ser Asp Glu Val Asn Cys Lys Asn Val Asn Gln Cys Leu Gly 
305                 310                 315                 320 


Pro Gly Lys Phe Lys Cys Arg Ser Gly Glu Cys Ile Asp Ile Ser Lys 
                325                 330                 335     


Val Cys Asn Gln Glu Gln Asp Cys Arg Asp Trp Ser Asp Glu Pro Leu 
            340                 345                 350         


Lys Glu Cys His Ile Asn Glu Cys Leu Val Asn Asn Gly Gly Cys Ser 
        355                 360                 365             


His Ile Cys Lys Asp Leu Val Ile Gly Tyr Glu Cys Asp Cys Ala Ala 
    370                 375                 380                 


Gly Phe Glu Leu Ile Asp Arg Lys Thr Cys Gly Asp Ile Asp Glu Cys 
385                 390                 395                 400 


Gln Asn Pro Gly Ile Cys Ser Gln Ile Cys Ile Asn Leu Lys Gly Gly 
                405                 410                 415     


Tyr Lys Cys Glu Cys Ser Arg Gly Tyr Gln Met Asp Leu Ala Thr Gly 
            420                 425                 430         


Val Cys Lys Ala Val Gly Lys Glu Pro Ser Leu Ile Phe Thr Asn Arg 
        435                 440                 445             


Arg Asp Ile Arg Lys Ile Gly Leu Glu Arg Lys Glu Tyr Ile Gln Leu 
    450                 455                 460                 


Val Glu Gln Leu Arg Asn Thr Val Ala Leu Asp Ala Asp Ile Ala Ala 
465                 470                 475                 480 


Gln Lys Leu Phe Trp Ala Asp Leu Ser Gln Lys Ala Ile Phe Ser Ala 
                485                 490                 495     


Ser Ile Asp Asp Lys Val Gly Arg His Val Lys Met Ile Asp Asn Val 
            500                 505                 510         


Tyr Asn Pro Ala Ala Ile Ala Val Asp Trp Val Tyr Lys Thr Ile Tyr 
        515                 520                 525             


Trp Thr Asp Ala Ala Ser Lys Thr Ile Ser Val Ala Thr Leu Asp Gly 
    530                 535                 540                 


Thr Lys Arg Lys Phe Leu Phe Asn Ser Asp Leu Arg Glu Pro Ala Ser 
545                 550                 555                 560 


Ile Ala Val Asp Pro Leu Ser Gly Phe Val Tyr Trp Ser Asp Trp Gly 
                565                 570                 575     


Glu Pro Ala Lys Ile Glu Lys Ala Gly Met Asn Gly Phe Asp Arg Arg 
            580                 585                 590         


Pro Leu Val Thr Ala Asp Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp 
        595                 600                 605             


Leu Ile Lys Ser Arg Leu Tyr Trp Leu Asp Ser Lys Leu His Met Leu 
    610                 615                 620                 


Ser Ser Val Asp Leu Asn Gly Gln Asp Arg Arg Ile Val Leu Lys Ser 
625                 630                 635                 640 


Leu Glu Phe Leu Ala His Pro Leu Ala Leu Thr Ile Phe Glu Asp Arg 
                645                 650                 655     


Val Tyr Trp Ile Asp Gly Glu Asn Glu Ala Val Tyr Gly Ala Asn Lys 
            660                 665                 670         


Phe Thr Gly Ser Glu Leu Ala Thr Leu Val Asn Asn Leu Asn Asp Ala 
        675                 680                 685             


Gln Asp Ile Ile Val Tyr His Glu Leu Val Gln Pro Ser Gly Lys Asn 
    690                 695                 700                 


Trp Cys Glu Glu Asp Met Glu Asn Gly Gly Cys Glu Tyr Leu Cys Leu 
705                 710                 715                 720 


Pro Ala Pro Gln Ile Asn Asp His Ser Pro Lys Tyr Thr Cys Ser Cys 
                725                 730                 735     


Pro Ser Gly Tyr Asn Val Glu Glu Asn Gly Arg Asp Cys Gln Ser Thr 
            740                 745                 750         


Ala Thr Thr Val Thr Tyr Ser Glu Thr Lys Asp Thr Asn Thr Thr Glu 
        755                 760                 765             


Ile Ser Ala Thr Ser Gly Leu Val Pro Gly Gly Ile Asn Val Thr Thr 
    770                 775                 780                 


Ala Val Ser Glu Val Ser Val Pro Pro Lys Gly Thr Ser Ala Ala Trp 
785                 790                 795                 800 


Ala Ile Leu Pro Leu Leu Leu Leu Val Met Ala Ala Val Gly Gly Tyr 
                805                 810                 815     


Leu Met Trp Arg Asn Trp Gln His Lys Asn Met Lys Ser Met Asn Phe 
            820                 825                 830         


Asp Asn Pro Val Tyr Leu Lys Thr Thr Glu Glu Asp Leu Ser Ile Asp 
        835                 840                 845             


Ile Gly Arg His Ser Ala Ser Val Gly His Thr Tyr Pro Ala Ile Ser 
    850                 855                 860                 


Val Val Ser Thr Asp Asp Asp Leu Ala 
865                 870             


<210> 59
<211> 845
<212> PRT
<213> Homo sapiens

<400> 59
Met Gly Thr Ser Ala Leu Trp Ala Leu Trp Leu Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Ala Pro Arg Glu Ser Gly Ala Thr Gly Thr Gly Arg Lys Ala Lys 
            20                  25                  30          


Cys Glu Pro Ser Gln Phe Gln Cys Thr Asn Gly Arg Cys Ile Thr Leu 
        35                  40                  45              


Leu Trp Lys Cys Asp Gly Asp Glu Asp Cys Val Asp Gly Ser Asp Glu 
    50                  55                  60                  


Lys Asn Cys Val Lys Lys Thr Cys Ala Glu Ser Asp Phe Val Cys Asn 
65                  70                  75                  80  


Asn Gly Gln Cys Val Pro Ser Arg Trp Lys Cys Asp Gly Asp Pro Asp 
                85                  90                  95      


Cys Glu Asp Gly Ser Asp Glu Ser Pro Glu Gln Cys His Met Arg Thr 
            100                 105                 110         


Cys Arg Ile His Glu Ile Ser Cys Gly Ala His Ser Thr Gln Cys Ile 
        115                 120                 125             


Pro Val Ser Trp Arg Cys Asp Gly Glu Asn Asp Cys Asp Ser Gly Glu 
    130                 135                 140                 


Asp Glu Glu Asn Cys Gly Asn Ile Thr Cys Ser Pro Asp Glu Phe Thr 
145                 150                 155                 160 


Cys Ser Ser Gly Arg Cys Ile Ser Arg Asn Phe Val Cys Asn Gly Gln 
                165                 170                 175     


Asp Asp Cys Ser Asp Gly Ser Asp Glu Leu Asp Cys Ala Pro Pro Thr 
            180                 185                 190         


Cys Gly Ala His Glu Phe Gln Cys Ser Thr Ser Ser Cys Ile Pro Ile 
        195                 200                 205             


Ser Trp Val Cys Asp Asp Asp Ala Asp Cys Ser Asp Gln Ser Asp Glu 
    210                 215                 220                 


Ser Leu Glu Gln Cys Gly Arg Gln Pro Val Ile His Thr Lys Cys Pro 
225                 230                 235                 240 


Ala Ser Glu Ile Gln Cys Gly Ser Gly Glu Cys Ile His Lys Lys Trp 
                245                 250                 255     


Arg Cys Asp Gly Asp Pro Asp Cys Lys Asp Gly Ser Asp Glu Val Asn 
            260                 265                 270         


Cys Pro Ser Arg Thr Cys Arg Pro Asp Gln Phe Glu Cys Glu Asp Gly 
        275                 280                 285             


Ser Cys Ile His Gly Ser Arg Gln Cys Asn Gly Ile Arg Asp Cys Val 
    290                 295                 300                 


Asp Gly Ser Asp Glu Val Asn Cys Lys Asn Val Asn Gln Cys Leu Gly 
305                 310                 315                 320 


Pro Gly Lys Phe Lys Cys Arg Ser Gly Glu Cys Ile Asp Ile Ser Lys 
                325                 330                 335     


Val Cys Asn Gln Glu Gln Asp Cys Arg Asp Trp Ser Asp Glu Pro Leu 
            340                 345                 350         


Lys Glu Cys His Ile Asn Glu Cys Leu Val Asn Asn Gly Gly Cys Ser 
        355                 360                 365             


His Ile Cys Lys Asp Leu Val Ile Gly Tyr Glu Cys Asp Cys Ala Ala 
    370                 375                 380                 


Gly Phe Glu Leu Ile Asp Arg Lys Thr Cys Gly Asp Ile Asp Glu Cys 
385                 390                 395                 400 


Gln Asn Pro Gly Ile Cys Ser Gln Ile Cys Ile Asn Leu Lys Gly Gly 
                405                 410                 415     


Tyr Lys Cys Glu Cys Ser Arg Gly Tyr Gln Met Asp Leu Ala Thr Gly 
            420                 425                 430         


Val Cys Lys Ala Val Gly Lys Glu Pro Ser Leu Ile Phe Thr Asn Arg 
        435                 440                 445             


Arg Asp Ile Arg Lys Ile Gly Leu Glu Arg Lys Glu Tyr Ile Gln Leu 
    450                 455                 460                 


Val Glu Gln Leu Arg Asn Thr Val Ala Leu Asp Ala Asp Ile Ala Ala 
465                 470                 475                 480 


Gln Lys Leu Phe Trp Ala Asp Leu Ser Gln Lys Ala Ile Phe Ser Ala 
                485                 490                 495     


Ser Ile Asp Asp Lys Val Gly Arg His Val Lys Met Ile Asp Asn Val 
            500                 505                 510         


Tyr Asn Pro Ala Ala Ile Ala Val Asp Trp Val Tyr Lys Thr Ile Tyr 
        515                 520                 525             


Trp Thr Asp Ala Ala Ser Lys Thr Ile Ser Val Ala Thr Leu Asp Gly 
    530                 535                 540                 


Thr Lys Arg Lys Phe Leu Phe Asn Ser Asp Leu Arg Glu Pro Ala Ser 
545                 550                 555                 560 


Ile Ala Val Asp Pro Leu Ser Gly Phe Val Tyr Trp Ser Asp Trp Gly 
                565                 570                 575     


Glu Pro Ala Lys Ile Glu Lys Ala Gly Met Asn Gly Phe Asp Arg Arg 
            580                 585                 590         


Pro Leu Val Thr Ala Asp Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp 
        595                 600                 605             


Leu Ile Lys Ser Arg Leu Tyr Trp Leu Asp Ser Lys Leu His Met Leu 
    610                 615                 620                 


Ser Ser Val Asp Leu Asn Gly Gln Asp Arg Arg Ile Val Leu Lys Ser 
625                 630                 635                 640 


Leu Glu Phe Leu Ala His Pro Leu Ala Leu Thr Ile Phe Glu Asp Arg 
                645                 650                 655     


Val Tyr Trp Ile Asp Gly Glu Asn Glu Ala Val Tyr Gly Ala Asn Lys 
            660                 665                 670         


Phe Thr Gly Ser Glu Leu Ala Thr Leu Val Asn Asn Leu Asn Asp Ala 
        675                 680                 685             


Gln Asp Ile Ile Val Tyr His Glu Leu Val Gln Pro Ser Gly Lys Asn 
    690                 695                 700                 


Trp Cys Glu Glu Asp Met Glu Asn Gly Gly Cys Glu Tyr Leu Cys Leu 
705                 710                 715                 720 


Pro Ala Pro Gln Ile Asn Asp His Ser Pro Lys Tyr Thr Cys Ser Cys 
                725                 730                 735     


Pro Ser Gly Tyr Asn Val Glu Glu Asn Gly Arg Asp Cys Gln Arg Ile 
            740                 745                 750         


Asn Val Thr Thr Ala Val Ser Glu Val Ser Val Pro Pro Lys Gly Thr 
        755                 760                 765             


Ser Ala Ala Trp Ala Ile Leu Pro Leu Leu Leu Leu Val Met Ala Ala 
    770                 775                 780                 


Val Gly Gly Tyr Leu Met Trp Arg Asn Trp Gln His Lys Asn Met Lys 
785                 790                 795                 800 


Ser Met Asn Phe Asp Asn Pro Val Tyr Leu Lys Thr Thr Glu Glu Asp 
                805                 810                 815     


Leu Ser Ile Asp Ile Gly Arg His Ser Ala Ser Val Gly His Thr Tyr 
            820                 825                 830         


Pro Ala Ile Ser Val Val Ser Thr Asp Asp Asp Leu Ala 
        835                 840                 845 


<210> 60
<211> 931
<212> PRT
<213> Homo sapiens

<400> 60
Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Glu Asn Phe Lys Val Asp Ile 
                805                 810                 815     


Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu 
            820                 825                 830         


Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly 
        835                 840                 845             


Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro 
    850                 855                 860                 


Ile Leu Ile Thr Ile Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly 
865                 870                 875                 880 


Ala Thr Cys Ala Gly Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly 
                885                 890                 895     


Leu Ser Ser Arg Ser Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu 
            900                 905                 910         


Tyr Asp Gly Leu Lys His Lys Val Lys Met Asn His Gln Lys Cys Cys 
        915                 920                 925             


Ser Glu Ala 
    930     


<210> 61
<211> 909
<212> PRT
<213> Homo sapiens

<400> 61
Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Asp Glu Tyr Glu Val Asp Trp Ser 
                805                 810                 815     


Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp Lys 
            820                 825                 830         


Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile 
        835                 840                 845             


Ala Met Ser Ser Leu Gly Val Leu Leu Gly Ala Thr Cys Ala Gly Leu 
    850                 855                 860                 


Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser Cys 
865                 870                 875                 880 


Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys His 
                885                 890                 895     


Lys Val Lys Met Asn His Gln Lys Cys Cys Ser Glu Ala 
            900                 905                 


<210> 62
<211> 926
<212> PRT
<213> Homo sapiens

<400> 62
Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Val Asp Ile Pro Glu Ile His Glu 
                805                 810                 815     


Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu Tyr Glu Val Asp Trp 
            820                 825                 830         


Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp 
        835                 840                 845             


Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile 
    850                 855                 860                 


Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly Ala Thr Cys Ala Gly 
865                 870                 875                 880 


Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser 
                885                 890                 895     


Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys 
            900                 905                 910         


His Lys Val Lys Met Asn His Gln Lys Cys Cys Ser Glu Ala 
        915                 920                 925     


<210> 63
<211> 901
<212> PRT
<213> Homo sapiens

<400> 63
Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Gly Thr Leu Leu Pro Gly Thr 
                805                 810                 815     


Glu Pro Thr Val Asp Thr Val Pro Met Gln Pro Ile Pro Ala Tyr Trp 
            820                 825                 830         


Tyr Tyr Val Met Ala Ala Gly Gly Ala Val Leu Val Leu Val Ser Val 
        835                 840                 845             


Ala Leu Ala Leu Val Leu His Tyr His Arg Phe Arg Tyr Ala Ala Lys 
    850                 855                 860                 


Lys Thr Asp His Ser Ile Thr Tyr Lys Thr Ser His Tyr Thr Asn Gly 
865                 870                 875                 880 


Ala Pro Leu Ala Val Glu Pro Thr Leu Thr Ile Lys Leu Glu Gln Asp 
                885                 890                 895     


Arg Gly Ser His Cys 
            900     


<210> 64
<211> 906
<212> PRT
<213> Homo sapiens

<400> 64
Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Glu Asn Phe Lys Gly Gly Thr 
                805                 810                 815     


Leu Leu Pro Gly Thr Glu Pro Thr Val Asp Thr Val Pro Met Gln Pro 
            820                 825                 830         


Ile Pro Ala Tyr Trp Tyr Tyr Val Met Ala Ala Gly Gly Ala Val Leu 
        835                 840                 845             


Val Leu Val Ser Val Ala Leu Ala Leu Val Leu His Tyr His Arg Phe 
    850                 855                 860                 


Arg Tyr Ala Ala Lys Lys Thr Asp His Ser Ile Thr Tyr Lys Thr Ser 
865                 870                 875                 880 


His Tyr Thr Asn Gly Ala Pro Leu Ala Val Glu Pro Thr Leu Thr Ile 
                885                 890                 895     


Lys Leu Glu Gln Asp Arg Gly Ser His Cys 
            900                 905     


<210> 65
<211> 555
<212> PRT
<213> Homo sapiens

<400> 65
Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Val Gly Cys Ser Trp Arg Pro Leu 
545                 550                 555 


<210> 66
<211> 572
<212> PRT
<213> Homo sapiens

<400> 66
Met Ser Tyr Gln Gly Lys Lys Asn Ile Pro Arg Ile Thr Ser Asp Arg 
1               5                   10                  15      


Leu Leu Ile Lys Gly Gly Lys Ile Val Asn Asp Asp Gln Ser Phe Tyr 
            20                  25                  30          


Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 
        35                  40                  45              


Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala His Ser Arg Met 
    50                  55                  60                  


Val Ile Pro Gly Gly Ile Asp Val His Thr Arg Phe Gln Met Pro Asp 
65                  70                  75                  80  


Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala 
                85                  90                  95      


Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro 
            100                 105                 110         


Gly Thr Ser Leu Leu Ala Ala Phe Asp Gln Trp Arg Glu Trp Ala Asp 
        115                 120                 125             


Ser Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Ser Glu Trp 
    130                 135                 140                 


His Lys Gly Ile Gln Glu Glu Met Glu Ala Leu Val Lys Asp His Gly 
145                 150                 155                 160 


Val Asn Ser Phe Leu Val Tyr Met Ala Phe Lys Asp Arg Phe Gln Leu 
                165                 170                 175     


Thr Asp Cys Gln Ile Tyr Glu Val Leu Ser Val Ile Arg Asp Ile Gly 
            180                 185                 190         


Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala Glu Glu 
        195                 200                 205             


Gln Gln Arg Ile Leu Asp Leu Gly Ile Thr Gly Pro Glu Gly His Val 
    210                 215                 220                 


Leu Ser Arg Pro Glu Glu Val Glu Ala Glu Ala Val Asn Arg Ala Ile 
225                 230                 235                 240 


Thr Ile Ala Asn Gln Thr Asn Cys Pro Leu Tyr Ile Thr Lys Val Met 
                245                 250                 255     


Ser Lys Ser Ser Ala Glu Val Ile Ala Gln Ala Arg Lys Lys Gly Thr 
            260                 265                 270         


Val Val Tyr Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser 
        275                 280                 285             


His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 
    290                 295                 300                 


Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Phe Leu Asn Ser Leu 
305                 310                 315                 320 


Leu Ser Cys Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe 
                325                 330                 335     


Asn Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro 
            340                 345                 350         


Glu Gly Thr Asn Gly Thr Glu Glu Arg Met Ser Val Ile Trp Asp Lys 
        355                 360                 365             


Ala Val Val Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr 
    370                 375                 380                 


Ser Thr Asn Ala Ala Lys Val Phe Asn Leu Tyr Pro Arg Lys Gly Arg 
385                 390                 395                 400 


Ile Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asp Pro Asp Ser 
                405                 410                 415     


Val Lys Thr Ile Ser Ala Lys Thr His Asn Ser Ser Leu Glu Tyr Asn 
            420                 425                 430         


Ile Phe Glu Gly Met Glu Cys Arg Gly Ser Pro Leu Val Val Ile Ser 
        435                 440                 445             


Gln Gly Lys Ile Val Leu Glu Asp Gly Thr Leu His Val Thr Glu Gly 
    450                 455                 460                 


Ser Gly Arg Tyr Ile Pro Arg Lys Pro Phe Pro Asp Phe Val Tyr Lys 
465                 470                 475                 480 


Arg Ile Lys Ala Arg Ser Arg Leu Ala Glu Leu Arg Gly Val Pro Arg 
                485                 490                 495     


Gly Leu Tyr Asp Gly Pro Val Cys Glu Val Ser Val Thr Pro Lys Thr 
            500                 505                 510         


Val Thr Pro Ala Ser Ser Ala Lys Thr Ser Pro Ala Lys Gln Gln Ala 
        515                 520                 525             


Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ala 
    530                 535                 540                 


Gln Ile Asp Asp Asn Ile Pro Arg Arg Thr Thr Gln Arg Ile Val Ala 
545                 550                 555                 560 


Pro Pro Gly Gly Arg Ala Asn Ile Thr Ser Leu Gly 
                565                 570         


<210> 67
<211> 536
<212> PRT
<213> Homo sapiens

<400> 67
Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn Leu Ile Val Pro 
1               5                   10                  15      


Gly Gly Val Lys Thr Ile Glu Ala His Ser Arg Met Val Ile Pro Gly 
            20                  25                  30          


Gly Ile Asp Val His Thr Arg Phe Gln Met Pro Asp Gln Gly Met Thr 
        35                  40                  45              


Ser Ala Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala Leu Ala Gly Gly 
    50                  55                  60                  


Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro Gly Thr Ser Leu 
65                  70                  75                  80  


Leu Ala Ala Phe Asp Gln Trp Arg Glu Trp Ala Asp Ser Lys Ser Cys 
                85                  90                  95      


Cys Asp Tyr Ser Leu His Val Asp Ile Ser Glu Trp His Lys Gly Ile 
            100                 105                 110         


Gln Glu Glu Met Glu Ala Leu Val Lys Asp His Gly Val Asn Ser Phe 
        115                 120                 125             


Leu Val Tyr Met Ala Phe Lys Asp Arg Phe Gln Leu Thr Asp Cys Gln 
    130                 135                 140                 


Ile Tyr Glu Val Leu Ser Val Ile Arg Asp Ile Gly Ala Ile Ala Gln 
145                 150                 155                 160 


Val His Ala Glu Asn Gly Asp Ile Ile Ala Glu Glu Gln Gln Arg Ile 
                165                 170                 175     


Leu Asp Leu Gly Ile Thr Gly Pro Glu Gly His Val Leu Ser Arg Pro 
            180                 185                 190         


Glu Glu Val Glu Ala Glu Ala Val Asn Arg Ala Ile Thr Ile Ala Asn 
        195                 200                 205             


Gln Thr Asn Cys Pro Leu Tyr Ile Thr Lys Val Met Ser Lys Ser Ser 
    210                 215                 220                 


Ala Glu Val Ile Ala Gln Ala Arg Lys Lys Gly Thr Val Val Tyr Gly 
225                 230                 235                 240 


Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser His Tyr Trp Ser 
                245                 250                 255     


Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser Pro Pro Leu Ser 
            260                 265                 270         


Pro Asp Pro Thr Thr Pro Asp Phe Leu Asn Ser Leu Leu Ser Cys Gly 
        275                 280                 285             


Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe Asn Thr Ala Gln 
    290                 295                 300                 


Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro Glu Gly Thr Asn 
305                 310                 315                 320 


Gly Thr Glu Glu Arg Met Ser Val Ile Trp Asp Lys Ala Val Val Thr 
                325                 330                 335     


Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr Ser Thr Asn Ala 
            340                 345                 350         


Ala Lys Val Phe Asn Leu Tyr Pro Arg Lys Gly Arg Ile Ala Val Gly 
        355                 360                 365             


Ser Asp Ala Asp Leu Val Ile Trp Asp Pro Asp Ser Val Lys Thr Ile 
    370                 375                 380                 


Ser Ala Lys Thr His Asn Ser Ser Leu Glu Tyr Asn Ile Phe Glu Gly 
385                 390                 395                 400 


Met Glu Cys Arg Gly Ser Pro Leu Val Val Ile Ser Gln Gly Lys Ile 
                405                 410                 415     


Val Leu Glu Asp Gly Thr Leu His Val Thr Glu Gly Ser Gly Arg Tyr 
            420                 425                 430         


Ile Pro Arg Lys Pro Phe Pro Asp Phe Val Tyr Lys Arg Ile Lys Ala 
        435                 440                 445             


Arg Ser Arg Leu Ala Glu Leu Arg Gly Val Pro Arg Gly Leu Tyr Asp 
    450                 455                 460                 


Gly Pro Val Cys Glu Val Ser Val Thr Pro Lys Thr Val Thr Pro Ala 
465                 470                 475                 480 


Ser Ser Ala Lys Thr Ser Pro Ala Lys Gln Gln Ala Pro Pro Val Arg 
                485                 490                 495     


Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ala Gln Ile Asp Asp 
            500                 505                 510         


Asn Ile Pro Arg Arg Thr Thr Gln Arg Ile Val Ala Pro Pro Gly Gly 
        515                 520                 525             


Arg Ala Asn Ile Thr Ser Leu Gly 
    530                 535     


<210> 68
<211> 923
<212> PRT
<213> Homo sapiens

<400> 68
Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
        915                 920             


<210> 69
<211> 644
<212> PRT
<213> Homo sapiens

<400> 69
Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Gly Ile Lys 
                


<210> 70
<211> 609
<212> PRT
<213> Homo sapiens

<400> 70
Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Gly Gly Thr Thr Val Leu 
            580                 585                 590         


Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Gly Ile 
        595                 600                 605             


Lys 
    


<210> 71
<211> 4
<212> PRT
<213> Homo sapiens

<400> 71
Tyr Arg Pro Trp 
1               


