                         SEQUENCE LISTING

<110>  The General Hospital Corporation
 
<120>  MODIFIED T CELLS AND METHODS OF THEIR USE

<130>  51295-019WO2

<150>  US 62/700,024
<151>  2018-07-18

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  183
<212>  PRT
<213>  Cytomegalovirus

<400>  1

Met Asp Leu Leu Ile Arg Leu Gly Phe Leu Leu Met Cys Ala Leu Pro 
1               5                   10                  15      


Thr Pro Gly Glu Arg Ser Ser Arg Asp Pro Lys Thr Leu Leu Ser Leu 
            20                  25                  30          


Ser Pro Arg Gln Gln Ala Cys Val Pro Arg Thr Lys Ser His Arg Pro 
        35                  40                  45              


Val Cys Tyr Asn Asp Thr Gly Asp Cys Thr Asp Ala Asp Asp Ser Trp 
    50                  55                  60                  


Lys Gln Leu Gly Glu Asp Phe Ala His Gln Cys Leu Gln Ala Ala Lys 
65                  70                  75                  80  


Lys Arg Pro Lys Thr His Lys Ser Arg Pro Asn Asp Arg Asn Leu Glu 
                85                  90                  95      


Gly Arg Leu Thr Cys Gln Arg Val Arg Arg Leu Leu Pro Cys Asp Leu 
            100                 105                 110         


Asp Ile His Pro Ser His Arg Leu Leu Thr Leu Met Asn Asn Cys Val 
        115                 120                 125             


Cys Asp Gly Ala Val Trp Asn Ala Phe Arg Leu Ile Glu Arg His Gly 
    130                 135                 140                 


Phe Phe Ala Val Thr Leu Tyr Leu Cys Cys Gly Ile Thr Leu Leu Val 
145                 150                 155                 160 


Val Ile Leu Ala Leu Leu Cys Ser Ile Thr Tyr Glu Ser Thr Gly Arg 
                165                 170                 175     


Gly Ile Arg Arg Cys Gly Ser 
            180             


<210>  2
<211>  88
<212>  PRT
<213>  Herpes simplex virus

<400>  2

Met Ser Trp Ala Leu Glu Met Ala Asp Thr Phe Leu Asp Thr Met Arg 
1               5                   10                  15      


Val Gly Pro Arg Thr Tyr Ala Asp Val Arg Asp Glu Ile Asn Lys Arg 
            20                  25                  30          


Gly Arg Glu Asp Arg Glu Ala Ala Arg Thr Ala Val His Asp Pro Glu 
        35                  40                  45              


Arg Pro Leu Leu Arg Ser Pro Gly Leu Leu Pro Glu Ile Ala Pro Asn 
    50                  55                  60                  


Ala Ser Leu Gly Val Ala His Arg Arg Thr Gly Gly Thr Val Thr Asp 
65                  70                  75                  80  


Ser Pro Arg Asn Pro Val Thr Arg 
                85              


<210>  3
<211>  96
<212>  PRT
<213>  Bovine herpes virus-1

<400>  3

Met Pro Arg Ser Pro Leu Ile Val Ala Val Val Ala Ala Ala Leu Phe 
1               5                   10                  15      


Ala Ile Val Arg Gly Arg Asp Pro Leu Leu Asp Ala Met Arg Arg Glu 
            20                  25                  30          


Gly Ala Met Asp Phe Trp Ser Ala Gly Cys Tyr Ala Arg Gly Val Pro 
        35                  40                  45              


Leu Ser Glu Pro Pro Gln Ala Leu Val Val Phe Tyr Val Ala Leu Thr 
    50                  55                  60                  


Ala Val Met Val Ala Val Ala Leu Tyr Ala Tyr Gly Leu Cys Phe Arg 
65                  70                  75                  80  


Leu Met Gly Ala Ser Gly Pro Asn Lys Lys Glu Ser Arg Gly Arg Gly 
                85                  90                  95      


<210>  4
<211>  60
<212>  PRT
<213>  Epstein Barr virus

<400>  4

Met Val His Val Leu Glu Arg Ala Leu Leu Glu Gln Gln Ser Ser Ala 
1               5                   10                  15      


Cys Gly Leu Pro Gly Ser Ser Thr Glu Thr Arg Pro Ser His Pro Cys 
            20                  25                  30          


Pro Glu Asp Pro Asp Val Ser Arg Leu Arg Leu Leu Leu Val Val Leu 
        35                  40                  45              


Cys Val Leu Phe Gly Leu Leu Cys Leu Leu Leu Ile 
    50                  55                  60  


<210>  5
<211>  221
<212>  PRT
<213>  Cytomegalovirus

<400>  5

Met Asn Lys Phe Ser Asn Thr Arg Ile Gly Phe Thr Cys Ala Val Met 
1               5                   10                  15      


Ala Pro Arg Thr Leu Ile Leu Thr Val Gly Leu Leu Cys Met Arg Ile 
            20                  25                  30          


Arg Ser Leu Leu Cys Ser Pro Ala Glu Thr Thr Val Thr Thr Ala Ala 
        35                  40                  45              


Val Thr Ser Ala His Gly Pro Leu Cys Pro Leu Val Phe Gln Gly Trp 
    50                  55                  60                  


Ala Tyr Ala Val Tyr His Gln Gly Asp Met Ala Leu Met Thr Leu Asp 
65                  70                  75                  80  


Val Tyr Cys Cys Arg Gln Thr Ser Asn Asn Thr Val Val Ala Phe Ser 
                85                  90                  95      


His His Pro Ala Asp Asn Thr Leu Leu Ile Glu Val Gly Asn Asn Thr 
            100                 105                 110         


Arg Arg His Val Asp Gly Ile Ser Cys Gln Asp His Phe Arg Ala Gln 
        115                 120                 125             


His Gln Asp Cys Pro Ala Gln Thr Val His Val Arg Gly Val Asn Glu 
    130                 135                 140                 


Ser Ala Phe Gly Leu Thr His Leu Gln Ser Cys Cys Leu Asn Glu His 
145                 150                 155                 160 


Ser Gln Leu Ser Glu Arg Val Ala Tyr His Leu Lys Leu Arg Pro Ala 
                165                 170                 175     


Thr Phe Gly Leu Glu Thr Trp Ala Met Tyr Thr Val Gly Ile Leu Ala 
            180                 185                 190         


Leu Gly Ser Phe Ser Ser Phe Tyr Ser Gln Ile Ala Arg Ser Leu Gly 
        195                 200                 205             


Val Leu Pro Asn Asp His His Tyr Ala Leu Lys Lys Ala 
    210                 215                 220     


<210>  6
<211>  368
<212>  PRT
<213>  Cytomegalovirus

<400>  6

Met Met Thr Met Trp Cys Leu Thr Leu Phe Val Leu Trp Met Leu Arg 
1               5                   10                  15      


Val Val Gly Met His Val Leu Arg Tyr Gly Tyr Thr Gly Ile Phe Asp 
            20                  25                  30          


Asp Thr Ser His Met Thr Leu Thr Val Val Gly Ile Phe Asp Gly Gln 
        35                  40                  45              


His Phe Phe Thr Tyr His Val Asn Ser Ser Asp Lys Ala Ser Ser Arg 
    50                  55                  60                  


Ala Asn Gly Thr Ile Ser Trp Met Ala Asn Val Ser Ala Ala Tyr Pro 
65                  70                  75                  80  


Thr Tyr Leu Asp Gly Glu Arg Ala Lys Gly Asp Leu Ile Phe Asn Gln 
                85                  90                  95      


Thr Glu Gln Asn Leu Leu Glu Leu Glu Ile Ala Leu Gly Tyr Arg Ser 
            100                 105                 110         


Gln Ser Val Leu Thr Trp Thr His Glu Cys Asn Thr Thr Glu Asn Gly 
        115                 120                 125             


Ser Phe Val Ala Gly Tyr Glu Gly Phe Gly Trp Asp Gly Glu Thr Leu 
    130                 135                 140                 


Met Glu Leu Lys Asp Asn Leu Thr Leu Trp Thr Gly Pro Asn Tyr Glu 
145                 150                 155                 160 


Ile Ser Trp Leu Lys Gln Asn Lys Thr Tyr Ile Asp Gly Lys Ile Lys 
                165                 170                 175     


Asn Ile Ser Glu Gly Asp Thr Thr Ile Gln Arg Asn Tyr Leu Lys Gly 
            180                 185                 190         


Asn Cys Thr Gln Trp Ser Val Ile Tyr Ser Gly Phe Gln Thr Pro Val 
        195                 200                 205             


Thr His Pro Val Val Lys Gly Gly Val Arg Asn Gln Asn Asp Asn Arg 
    210                 215                 220                 


Ala Glu Ala Phe Cys Thr Ser Tyr Gly Phe Phe Pro Gly Glu Ile Asn 
225                 230                 235                 240 


Ile Thr Phe Ile His Tyr Gly Asn Lys Ala Pro Asp Asp Ser Glu Pro 
                245                 250                 255     


Gln Cys Asn Pro Leu Leu Pro Thr Phe Asp Gly Thr Phe His Gln Gly 
            260                 265                 270         


Cys Tyr Val Ala Ile Phe Cys Asn Gln Asn Tyr Thr Cys Arg Val Thr 
        275                 280                 285             


His Gly Asn Trp Thr Val Glu Ile Pro Ile Ser Val Thr Ser Pro Asp 
    290                 295                 300                 


Asp Ser Ser Ser Gly Glu Val Pro Asp His Pro Thr Ala Asn Lys Arg 
305                 310                 315                 320 


Tyr Asn Thr Met Thr Ile Ser Ser Val Leu Leu Ala Leu Leu Leu Cys 
                325                 330                 335     


Ala Leu Leu Phe Ala Phe Leu His Tyr Phe Thr Thr Leu Lys Gln Tyr 
            340                 345                 350         


Leu Arg Asn Leu Ala Phe Ala Trp Arg Tyr Arg Lys Val Arg Ser Ser 
        355                 360                 365             


<210>  7
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser 
    50                  55                  60                  


Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln 
                85                  90                  95      


Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly 
        115                 120                 125             


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala 
305                 310                 315                 320 


Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Asp 
        


<210>  8
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro 
    50                  55                  60                  


Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 
65                  70                  75                  80  


Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 
                85                  90                  95      


Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Gly 
        115                 120                 125             


Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala 
145                 150                 155                 160 


Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His 
                165                 170                 175     


Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr 
            180                 185                 190         


Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr 
        195                 200                 205             


His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 
225                 230                 235                 240 


Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
                325                 330                 335     


Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Glu Ser His Ser Leu 
        355             


<210>  9
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  10
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  11
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  12
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
cagttgccga ttacaggta                                                    19


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
gtggaaggcg cttttcaccg                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
agagtctctc agctggtaca                                                   20


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
acagttgccg attacaggta ggg                                               23


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
gcagttgccg attacaggta                                                   20


