                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  Non-Human Animal Models of Ditra Disease and Uses Thereof

<130>  35950PCT (10404WO01)

<150>  62/698,459
<151>  2018-07-16

<150>  62/867,477
<151>  2019-06-27

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  2628
<212>  DNA
<213>  Homo sapiens

<400>  1
cccgcccacg gtggcgggga aatacctagg catggaagtg gcatgacagg gctcgtgtcc       60

ctgtcatatt ttccactctc cacgaggtcc tgcgcgcttc aatcctgcag gcagcccggt      120

ttggggatgt ggtccttgct gctctgcggg ttgtccatcg cccttccact gtctgtcaca      180

gcagatggat gcaaggacat ttttatgaaa aatgagatac tttcagcaag ccagcctttt      240

gcttttaatt gtacattccc tcccataaca tctggggaag tcagtgtaac atggtataaa      300

aattctagca aaatcccagt gtccaaaatc atacagtcta gaattcacca ggacgagact      360

tggattttgt ttctccccat ggaatggggg gactcaggag tctaccaatg tgttataaag      420

ggtagagaca gctgtcatag aatacatgta aacctaactg tttttgaaaa acattggtgt      480

gacacttcca taggtggttt accaaattta tcagatgagt acaagcaaat attacatctt      540

ggaaaagatg atagtctcac atgtcatctg cacttcccga agagttgtgt tttgggtcca      600

ataaagtggt ataaggactg taacgagatt aaaggggagc ggttcactgt tttggaaacc      660

aggcttttgg tgagcaatgt ctcggcagag gacagaggga actacgcgtg tcaagccata      720

ctgacacact cagggaagca gtacgaggtt ttaaatggca tcactgtgag cattacagaa      780

agagctggat atggaggaag tgtccctaaa atcatttatc caaaaaatca ttcaattgaa      840

gtacagcttg gtaccactct gattgtggac tgcaatgtaa cagacaccaa ggataataca      900

aatctacgat gctggagagt caataacact ttggtggatg attactatga tgaatccaaa      960

cgaatcagag aaggggtgga aacccatgtc tcttttcggg aacataattt gtacacagta     1020

aacatcacct tcttggaagt gaaaatggaa gattatggcc ttcctttcat gtgccacgct     1080

ggagtgtcca cagcatacat tatattacag ctcccagctc cggattttcg agcttacttg     1140

ataggagggc ttatcgcctt ggtggctgtg gctgtgtctg ttgtgtacat atacaacatt     1200

tttaagatcg acattgttct ttggtatcga agtgccttcc attctacaga gaccatagta     1260

gatgggaagc tgtatgacgc ctatgtctta taccccaagc cccacaagga aagccagagg     1320

catgccgtgg atgccctggt gttgaatatc ctgcccgagg tgttggagag acaatgtgga     1380

tataagttgt ttatattcgg cagagatgaa ttccctggac aagccgtggc caatgtcatc     1440

gatgaaaacg ttaagctgtg caggaggctg attgtcattg tggtccccga atcgctgggc     1500

tttggcctgt tgaagaacct gtcagaagaa caaatcgcgg tctacagtgc cctgatccag     1560

gacgggatga aggttattct cattgagctg gagaaaatcg aggactacac agtcatgcca     1620

gagtcaattc agtacatcaa acagaagcat ggtgccatcc ggtggcatgg ggacttcacg     1680

gagcagtcac agtgtatgaa gaccaagttt tggaagacag tgagatacca catgccgccc     1740

agaaggtgtc ggccgtttcc tccggtccag ctgctgcagc acacaccttg ctaccgcacc     1800

gcaggcccag aactaggctc aagaagaaag aagtgtactc tcacgactgg ctaagacttg     1860

ctggactgac acctatggct ggaagatgac ttgttttgct ccatgtctcc tcattcctac     1920

acctattttc tgctgcagga tgaggctagg gttagcattc tagacaccca gttgagctca     1980

ggcgtagaga agaggaggat gggataagaa ctggggccat ccccatgtca tggtgggtga     2040

gagctggggc catccccgtg gtcatggagg gtgagagctg ggggttatcc ccatggtcat     2100

ggagggtgag ggctggtcgg gggaggcatc cccaagtcat ggtgggtgag agctcggagc     2160

atccccatgt catggtgggt gagatctggg ggtatccctg tgtcatggtg ggtgagggcg     2220

ggtggtcatc cacatggtca tagtgggtga gagctggggg tatccctaca tcatggtggg     2280

tgagagctgg gagcatcccc atgtcatggt gggcgagatc tggggggtat ccccacgtca     2340

tggtggatga gagctggggg aatcaccatg tcatggtggg tgagatcttg ggggatcacc     2400

tgtcatggtg ggtgagagct ggggggatca cctgtcatgg tgggtgagag ttgggattca     2460

tccccatgtc atggtgggct gagcccacat ggaagcctgt gcttggacag cgtatgccct     2520

tttctctgtt tttccacaat gaacaattaa actgtaaatg ttaaaaatat cagtaatttg     2580

tgaaataaat tttattctca tttgagcaac ataaaaaaaa aaaaaaaa                  2628


<210>  2
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Trp Ser Leu Leu Leu Cys Gly Leu Ser Ile Ala Leu Pro Leu Ser 
1               5                   10                  15      


Val Thr Ala Asp Gly Cys Lys Asp Ile Phe Met Lys Asn Glu Ile Leu 
            20                  25                  30          


Ser Ala Ser Gln Pro Phe Ala Phe Asn Cys Thr Phe Pro Pro Ile Thr 
        35                  40                  45              


Ser Gly Glu Val Ser Val Thr Trp Tyr Lys Asn Ser Ser Lys Ile Pro 
    50                  55                  60                  


Val Ser Lys Ile Ile Gln Ser Arg Ile His Gln Asp Glu Thr Trp Ile 
65                  70                  75                  80  


Leu Phe Leu Pro Met Glu Trp Gly Asp Ser Gly Val Tyr Gln Cys Val 
                85                  90                  95      


Ile Lys Gly Arg Asp Ser Cys His Arg Ile His Val Asn Leu Thr Val 
            100                 105                 110         


Phe Glu Lys His Trp Cys Asp Thr Ser Ile Gly Gly Leu Pro Asn Leu 
        115                 120                 125             


Ser Asp Glu Tyr Lys Gln Ile Leu His Leu Gly Lys Asp Asp Ser Leu 
    130                 135                 140                 


Thr Cys His Leu His Phe Pro Lys Ser Cys Val Leu Gly Pro Ile Lys 
145                 150                 155                 160 


Trp Tyr Lys Asp Cys Asn Glu Ile Lys Gly Glu Arg Phe Thr Val Leu 
                165                 170                 175     


Glu Thr Arg Leu Leu Val Ser Asn Val Ser Ala Glu Asp Arg Gly Asn 
            180                 185                 190         


Tyr Ala Cys Gln Ala Ile Leu Thr His Ser Gly Lys Gln Tyr Glu Val 
        195                 200                 205             


Leu Asn Gly Ile Thr Val Ser Ile Thr Glu Arg Ala Gly Tyr Gly Gly 
    210                 215                 220                 


Ser Val Pro Lys Ile Ile Tyr Pro Lys Asn His Ser Ile Glu Val Gln 
225                 230                 235                 240 


Leu Gly Thr Thr Leu Ile Val Asp Cys Asn Val Thr Asp Thr Lys Asp 
                245                 250                 255     


Asn Thr Asn Leu Arg Cys Trp Arg Val Asn Asn Thr Leu Val Asp Asp 
            260                 265                 270         


Tyr Tyr Asp Glu Ser Lys Arg Ile Arg Glu Gly Val Glu Thr His Val 
        275                 280                 285             


Ser Phe Arg Glu His Asn Leu Tyr Thr Val Asn Ile Thr Phe Leu Glu 
    290                 295                 300                 


Val Lys Met Glu Asp Tyr Gly Leu Pro Phe Met Cys His Ala Gly Val 
305                 310                 315                 320 


Ser Thr Ala Tyr Ile Ile Leu Gln Leu Pro Ala Pro Asp Phe Arg Ala 
                325                 330                 335     


Tyr Leu Ile Gly Gly Leu Ile Ala Leu Val Ala Val Ala Val Ser Val 
            340                 345                 350         


Val Tyr Ile Tyr Asn Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Ser Ala Phe His Ser Thr Glu Thr Ile Val Asp Gly Lys Leu Tyr Asp 
    370                 375                 380                 


Ala Tyr Val Leu Tyr Pro Lys Pro His Lys Glu Ser Gln Arg His Ala 
385                 390                 395                 400 


Val Asp Ala Leu Val Leu Asn Ile Leu Pro Glu Val Leu Glu Arg Gln 
                405                 410                 415     


Cys Gly Tyr Lys Leu Phe Ile Phe Gly Arg Asp Glu Phe Pro Gly Gln 
            420                 425                 430         


Ala Val Ala Asn Val Ile Asp Glu Asn Val Lys Leu Cys Arg Arg Leu 
        435                 440                 445             


Ile Val Ile Val Val Pro Glu Ser Leu Gly Phe Gly Leu Leu Lys Asn 
    450                 455                 460                 


Leu Ser Glu Glu Gln Ile Ala Val Tyr Ser Ala Leu Ile Gln Asp Gly 
465                 470                 475                 480 


Met Lys Val Ile Leu Ile Glu Leu Glu Lys Ile Glu Asp Tyr Thr Val 
                485                 490                 495     


Met Pro Glu Ser Ile Gln Tyr Ile Lys Gln Lys His Gly Ala Ile Arg 
            500                 505                 510         


Trp His Gly Asp Phe Thr Glu Gln Ser Gln Cys Met Lys Thr Lys Phe 
        515                 520                 525             


Trp Lys Thr Val Arg Tyr His Met Pro Pro Arg Arg Cys Arg Pro Phe 
    530                 535                 540                 


Pro Pro Val Gln Leu Leu Gln His Thr Pro Cys Tyr Arg Thr Ala Gly 
545                 550                 555                 560 


Pro Glu Leu Gly Ser Arg Arg Lys Lys Cys Thr Leu Thr Thr Gly 
                565                 570                 575 


<210>  3
<211>  4072
<212>  DNA
<213>  Mus musculus

<400>  3
ggcggacaga gaccggaagc tgggagatga tggcttctga tgtttgttgc ttacgcgaca       60

cagcttgttt ggaattatgt ggcccttgac aactgcgtgg cacacacttc aagatacaaa      120

agtgagaaga agaggggggt caccagagga gactgaagtc agtaagtttc taccaaagct      180

gggtttcttc tggccactcc aaacaaagct gaaattgtcc ttcagacctc tcctgagatg      240

ggggttacat ctttgctctt ctgtggggtg tttttcctgc ttctgctttt cgtggcagca      300

gatacgtgtg aggacatttt tatgcacaat gtgataattt cagagggcca gccttttcct      360

ttcaactgca catacccgcc agaaacaaac ggggcagtaa atctgacatg gtacaaaaca      420

cctagcaaaa gcccagtatc taacaacaga caccttagag ttcaccagga ccagacctgg      480

atcttgtttc ttccattgac actggaggac tccggtatct atcagtgtgt tataaggaat      540

gcccacaact gctaccaaat agctgtgaac ctaaccgttt taaaaaacca ctggtgtgac      600

tcttccatgg aggggagtcc cgtaaattca ccagatgtgt accagcaaat attacccata      660

ggaaaatcgg gcagtctgaa ttgtcatctc tacttcccag aaagttgtgc tttggattca      720

ataaaatggt ataagggttg tgaagagatt aaagcgggga aaaagtacag cccttcagga      780

gcaaagcttc ttgtgaacaa cgttgctgtg gaggacggcg ggagctatgc gtgctcagcc      840

agactgactc acttggggag acacttcacc attagaaact acattgctgt gaacaccaag      900

gaagttgagt atggaagaag gatccctaac atcacgtatc caaagaacaa ctccattgaa      960

gttccacttg gctccaccct catcgtgaac tgcaatataa cagacacgaa ggagaataca     1020

aacctgaggt gctggagagt caacaacacc ctggtggatg actactacaa agactccaaa     1080

cgcatccagg aaggaatcga aaccaatgtg tccttgaggg atcaaattcg gtacacagtg     1140

aacataacat tcttaaaagt gaaaatggag gactacggcc gtcctttcac gtgtcatgct     1200

ggagtgtccg cagcctacat cattctgata tacccagttc cagacttcag ggcttacctc     1260

ttaggagggc ttatggcgtt cctacttctg gttgtatctg ttctgttcat ctacaacagc     1320

tttaagatcg acatcatgct ttggtacaga agcgccttcc acactgccca ggctccagat     1380

gatgagaagc tgtatgatgc ctatgtctta taccccaagt acccgagagg aagccagggc     1440

catgatgtag acacactggt actgaagatc ttgcccgagg tgctggagaa acagtgtgga     1500

tataagttat ttatatttgg cagggatgaa ttccctggac aagctgtggc cagcgtcatt     1560

gatgaaaaca ttaagctgtg taggaggctg atggtctttg tggcaccaga gtcgtctagc     1620

ttcggctttc taaagaactt gtcagaagaa caaattgccg tctacaatgc cctcatccag     1680

catggcatga aggtcattct gatcgaactg gagaaagtca aagactacag caccatgccc     1740

gagtccattc agtatatccg acagaagcac ggggccatcc aatgggatgg ggacttcaca     1800

gagcagtcac agtgtgccaa gaccaagttc tggaagaaag tgagatacca tatgccaccc     1860

aggaggtatc cagcatcttc cccagtccag ctgctgggac acataccctg caattgcaag     1920

gcaggcaaat gcaatgctgc cacagggctc ataactccct gagagtggtt agtgtgtgtt     1980

ggctcacact acatcctctc tgaattgtct actcatgtag ctggctcttt tgtgcttgtg     2040

agcgaccttg tccttgccct tgtagctttt tgtttatttg tattgtttgc tggatgcttt     2100

cagtcatagc tgatccttat tactcctgtt tgcttcatgg ctcctgaaaa cccatatact     2160

ccccaagcat ggggtggctc taacgttggg cctccgtgtc agtgggatac tgaggatgac     2220

agatcaggtg tccaggatgc ttgatcctgg tttgagatgg gaggctgggc agtctgagga     2280

taccaagtag atagccttag ggaagatcag caaggacagt agtgcaatgt ctgtgtttgt     2340

ccagggtcca caagattcta gtcctcaggc agtgtagact gcatttgaat ctccttcatt     2400

ttcctattgc atttagttaa ctaaccattg tgagaacagg acagaggact gggagttggg     2460

ggtgggggga ggtgacagag gatgggagtg tgtgtgtaag aggtgacagt tacatgatca     2520

atcctgggaa atcagactca ggaaaccagc attagggtgc agatctgagt tttttgtgca     2580

gcccttaagc ttatatacag cgttcgagcc aatcccaagc ccctaaaccc tcggccaatc     2640

atatcttgcc acatcatcac tatgcctcaa tgaaagccct gcctgatgag gtaactcaaa     2700

aggaattggg gtgggaagca tcatcccctg tcagaacttc cgtgaagatg gaggacgtag     2760

ccactacccc acctcagttt ctttttgttg tctcaggttt gcaccagagc catcttaaat     2820

ctagtgacat gtgcagcaaa tcatgactct tcaaggagct gcgggagcct gtggtgcctc     2880

gctctccatc ccactttttc cttcacaggg ttgacttcca cgtcccccaa accatggtat     2940

tagcacgatg cccctagaag ccgcttagat gtcgccagga ccaatggtct tcatttccct     3000

ctttcccagc ccctgtgaat cttactattc taggaaattc aaatgagaga cacggtgcat     3060

tcacggtttc tcattttatg actggcttct ttcatacacc acggatttct caagtgctct     3120

cgagattcat ccattgatta gccttttgtt ttattattat cactactgtc tttctcttct     3180

ttttcttcct ctttaaattt ctccccctcc tcacgagcat ccggagagga gcatagactc     3240

tctgcatgcc tacagcgtga tgagctcacc gagggtccct tcaatcacaa gcttgtatgt     3300

tttgcttttc ggtttctctt tgcaccatgg gaattgtaac tccttacaga ggatttgaag     3360

gttcgggtac aaaggcgtca ctgactggtt ccttcttctg tcttcctcac cctgaatggg     3420

ctttgcttct gggtgattcc tggaaattgt cagcagtgat ggagaaacct agggacaggg     3480

ctgactaatg gggcctggcc tttcttcttt gaagcccagg acacagtgcc tgcctagtgg     3540

gtcctggaca caccaggtgg ttccactctg ctcagtggta acatttttta gctgagtcat     3600

caacatcggg tcctttagtg aggaggtgcg ggcatctctc cccagttaga tttggactct     3660

tacttccctg ctcatttccc tttgaaagat tcaggagact atgtcagaag cagggagcca     3720

gcaccctgtg tcttctccac gtggctcctt gtcacacctg tgaccaccaa ttttagaaaa     3780

tgtgtttcct tgttctgacc acacttatgc ggacattagt tgaggctgtt gtcagaaagg     3840

aaaattaact catttgaagt aaacattttc tggaaatctc tgacttctgt caggccaatg     3900

gtgctgaaaa atttaaaact gaattcactt ttttggccag aaagctttcc tcttgccaac     3960

atgtcttaat tttccttttg cttaaactta ttggagatgt attatgaatg ctaagatgtg     4020

agtgtgttat atcagtacat tgacatttta aataaagtat attttaataa aa             4072


<210>  4
<211>  574
<212>  PRT
<213>  Mus musculus

<400>  4

Met Gly Val Thr Ser Leu Leu Phe Cys Gly Val Phe Phe Leu Leu Leu 
1               5                   10                  15      


Leu Phe Val Ala Ala Asp Thr Cys Glu Asp Ile Phe Met His Asn Val 
            20                  25                  30          


Ile Ile Ser Glu Gly Gln Pro Phe Pro Phe Asn Cys Thr Tyr Pro Pro 
        35                  40                  45              


Glu Thr Asn Gly Ala Val Asn Leu Thr Trp Tyr Lys Thr Pro Ser Lys 
    50                  55                  60                  


Ser Pro Val Ser Asn Asn Arg His Leu Arg Val His Gln Asp Gln Thr 
65                  70                  75                  80  


Trp Ile Leu Phe Leu Pro Leu Thr Leu Glu Asp Ser Gly Ile Tyr Gln 
                85                  90                  95      


Cys Val Ile Arg Asn Ala His Asn Cys Tyr Gln Ile Ala Val Asn Leu 
            100                 105                 110         


Thr Val Leu Lys Asn His Trp Cys Asp Ser Ser Met Glu Gly Ser Pro 
        115                 120                 125             


Val Asn Ser Pro Asp Val Tyr Gln Gln Ile Leu Pro Ile Gly Lys Ser 
    130                 135                 140                 


Gly Ser Leu Asn Cys His Leu Tyr Phe Pro Glu Ser Cys Ala Leu Asp 
145                 150                 155                 160 


Ser Ile Lys Trp Tyr Lys Gly Cys Glu Glu Ile Lys Ala Gly Lys Lys 
                165                 170                 175     


Tyr Ser Pro Ser Gly Ala Lys Leu Leu Val Asn Asn Val Ala Val Glu 
            180                 185                 190         


Asp Gly Gly Ser Tyr Ala Cys Ser Ala Arg Leu Thr His Leu Gly Arg 
        195                 200                 205             


His Phe Thr Ile Arg Asn Tyr Ile Ala Val Asn Thr Lys Glu Val Glu 
    210                 215                 220                 


Tyr Gly Arg Arg Ile Pro Asn Ile Thr Tyr Pro Lys Asn Asn Ser Ile 
225                 230                 235                 240 


Glu Val Pro Leu Gly Ser Thr Leu Ile Val Asn Cys Asn Ile Thr Asp 
                245                 250                 255     


Thr Lys Glu Asn Thr Asn Leu Arg Cys Trp Arg Val Asn Asn Thr Leu 
            260                 265                 270         


Val Asp Asp Tyr Tyr Lys Asp Ser Lys Arg Ile Gln Glu Gly Ile Glu 
        275                 280                 285             


Thr Asn Val Ser Leu Arg Asp Gln Ile Arg Tyr Thr Val Asn Ile Thr 
    290                 295                 300                 


Phe Leu Lys Val Lys Met Glu Asp Tyr Gly Arg Pro Phe Thr Cys His 
305                 310                 315                 320 


Ala Gly Val Ser Ala Ala Tyr Ile Ile Leu Ile Tyr Pro Val Pro Asp 
                325                 330                 335     


Phe Arg Ala Tyr Leu Leu Gly Gly Leu Met Ala Phe Leu Leu Leu Val 
            340                 345                 350         


Val Ser Val Leu Phe Ile Tyr Asn Ser Phe Lys Ile Asp Ile Met Leu 
        355                 360                 365             


Trp Tyr Arg Ser Ala Phe His Thr Ala Gln Ala Pro Asp Asp Glu Lys 
    370                 375                 380                 


Leu Tyr Asp Ala Tyr Val Leu Tyr Pro Lys Tyr Pro Arg Gly Ser Gln 
385                 390                 395                 400 


Gly His Asp Val Asp Thr Leu Val Leu Lys Ile Leu Pro Glu Val Leu 
                405                 410                 415     


Glu Lys Gln Cys Gly Tyr Lys Leu Phe Ile Phe Gly Arg Asp Glu Phe 
            420                 425                 430         


Pro Gly Gln Ala Val Ala Ser Val Ile Asp Glu Asn Ile Lys Leu Cys 
        435                 440                 445             


Arg Arg Leu Met Val Phe Val Ala Pro Glu Ser Ser Ser Phe Gly Phe 
    450                 455                 460                 


Leu Lys Asn Leu Ser Glu Glu Gln Ile Ala Val Tyr Asn Ala Leu Ile 
465                 470                 475                 480 


Gln His Gly Met Lys Val Ile Leu Ile Glu Leu Glu Lys Val Lys Asp 
                485                 490                 495     


Tyr Ser Thr Met Pro Glu Ser Ile Gln Tyr Ile Arg Gln Lys His Gly 
            500                 505                 510         


Ala Ile Gln Trp Asp Gly Asp Phe Thr Glu Gln Ser Gln Cys Ala Lys 
        515                 520                 525             


Thr Lys Phe Trp Lys Lys Val Arg Tyr His Met Pro Pro Arg Arg Tyr 
    530                 535                 540                 


Pro Ala Ser Ser Pro Val Gln Leu Leu Gly His Ile Pro Cys Asn Cys 
545                 550                 555                 560 


Lys Ala Gly Lys Cys Asn Ala Ala Thr Gly Leu Ile Thr Pro 
                565                 570                 


<210>  5
<211>  2044
<212>  DNA
<213>  Rattus norvegicus

<400>  5
ccggctggcc taggatcagg caagaaaagg ctgaacgcct ttctaaggac ggactctttc       60

tgtacagctc cacttgggga agcccgaaat ggggatgcca cccttgctct tctgttgggt      120

gtctttcgtg cttccacttt ttgtggcagc aggtaactgt actgatgtct atatgcacca      180

tgagatgatt tcagagggcc agcctttccc cttcaactgc acataccctc cagtaacaaa      240

cggggcagtg aatctgacat ggcatagaac acccagtaag agcccaatct ccatcaacag      300

acacgttaga attcaccagg accagtcctg gattttgttt cttccgttgg cattggagga      360

ctcaggcatc tatcaatgtg ttataaagga tgcccacagc tgttaccgaa tagctataaa      420

cctaaccgtt tttagaaaac actggtgcga ctcttccaac gaagagagtt ccataaattc      480

ctcagatgag taccagcaat ggttacccat aggaaaatcg ggcagtctga cgtgccatct      540

ctacttccca gagagctgtg ttttggattc aataaagtgg tataagggtt gtgaagagat      600

taaagtgagc aagaagtttt gccctacagg aacaaagctt cttgttaaca acatcgacgt      660

ggaggatagt gggagctatg catgctcagc cagactgaca cacttgggga gaatcttcac      720

ggttagaaac tacattgctg tgaataccaa ggaagttggg tctggaggaa ggatccctaa      780

catcacgtat ccaaaaaaca actccattga agttcaactt ggctccaccc tcattgtgga      840

ctgcaatata acagacacga aggagaatac gaacctcaga tgctggcgag ttaacaacac      900

cctggtggac gattactaca acgacttcaa acgcatccag gaaggaatcg aaaccaatct      960

gtctctgagg aatcacattc tgtacacagt gaacataaca ttcttagaag tgaaaatgga     1020

ggactacggc catcctttca catgccacgc tgcggtgtcc gcagcctaca tcattctgaa     1080

acgcccagct ccagacttcc gggcttacct cataggaggt ctcatggctt tcctacttct     1140

ggccgtgtcc attctgtaca tctacaacac ctttaaggtc gacatcgtgc tttggtatag     1200

gagtaccttc cacactgccc aggctccaga tgacgagaag ctgtatgatg cctatgtctt     1260

ataccccaag tacccaagag aaagccaggg ccatgatgtg gacacactgg tgttgaagat     1320

cttgcccgag gtgctggaga aacagtgtgg atataagtta ttcatatttg gcagggatga     1380

attccctgga caagctgtgg ccagcgtcat tgatgaaaac attaagctgt gtaggaggct     1440

gatggtcctc gtggcaccag agacatccag cttcagcttt ctgaagaact tgactgaaga     1500

acaaatcgct gtctacaatg ccctcgtcca ggacggcatg aaggtcattc tgattgaact     1560

ggagagagtc aaggactaca gcaccatgcc cgagtccatt cagtacatcc gacagaagca     1620

cggggccatc cagtgggatg gggacttcac agagcaggca cagtgcgcca agacgaaatt     1680

ctggaagaaa gtgagatatc atatgccacc caggaggtac ccggcatctc cccccgtcca     1740

gctgctagga cacacacccc gcataccagg ctagtgcagt gccaccgcca cggggctcat     1800

aactccttaa gagcggttag tgtgtggtgg ctcgcactac aacctctctg gatcatctac     1860

ccccgtagct tgctcttttg tgcttgtgag cgacctcgtc cttagccacg tcatattttg     1920

attttttgtt tgttttgttt gtttgttgta tgcttttagt catagctgat tcgtactact     1980

cctgtttgct tcatggttcc tgaatcccag agactccctg agcatgggtg gctatcatgt     2040

tggg                                                                  2044


<210>  6
<211>  561
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Gly Met Pro Pro Leu Leu Phe Cys Trp Val Ser Phe Val Leu Pro 
1               5                   10                  15      


Leu Phe Val Ala Ala Gly Asn Cys Thr Asp Val Tyr Met His His Glu 
            20                  25                  30          


Met Ile Ser Glu Gly Gln Pro Phe Pro Phe Asn Cys Thr Tyr Pro Pro 
        35                  40                  45              


Val Thr Asn Gly Ala Val Asn Leu Thr Trp His Arg Thr Pro Ser Lys 
    50                  55                  60                  


Ser Pro Ile Ser Ile Asn Arg His Val Arg Ile His Gln Asp Gln Ser 
65                  70                  75                  80  


Trp Ile Leu Phe Leu Pro Leu Ala Leu Glu Asp Ser Gly Ile Tyr Gln 
                85                  90                  95      


Cys Val Ile Lys Asp Ala His Ser Cys Tyr Arg Ile Ala Ile Asn Leu 
            100                 105                 110         


Thr Val Phe Arg Lys His Trp Cys Asp Ser Ser Asn Glu Glu Ser Ser 
        115                 120                 125             


Ile Asn Ser Ser Asp Glu Tyr Gln Gln Trp Leu Pro Ile Gly Lys Ser 
    130                 135                 140                 


Gly Ser Leu Thr Cys His Leu Tyr Phe Pro Glu Ser Cys Val Leu Asp 
145                 150                 155                 160 


Ser Ile Lys Trp Tyr Lys Gly Cys Glu Glu Ile Lys Val Ser Lys Lys 
                165                 170                 175     


Phe Cys Pro Thr Gly Thr Lys Leu Leu Val Asn Asn Ile Asp Val Glu 
            180                 185                 190         


Asp Ser Gly Ser Tyr Ala Cys Ser Ala Arg Leu Thr His Leu Gly Arg 
        195                 200                 205             


Ile Phe Thr Val Arg Asn Tyr Ile Ala Val Asn Thr Lys Glu Val Gly 
    210                 215                 220                 


Ser Gly Gly Arg Ile Pro Asn Ile Thr Tyr Pro Lys Asn Asn Ser Ile 
225                 230                 235                 240 


Glu Val Gln Leu Gly Ser Thr Leu Ile Val Asp Cys Asn Ile Thr Asp 
                245                 250                 255     


Thr Lys Glu Asn Thr Asn Leu Arg Cys Trp Arg Val Asn Asn Thr Leu 
            260                 265                 270         


Val Asp Asp Tyr Tyr Asn Asp Phe Lys Arg Ile Gln Glu Gly Ile Glu 
        275                 280                 285             


Thr Asn Leu Ser Leu Arg Asn His Ile Leu Tyr Thr Val Asn Ile Thr 
    290                 295                 300                 


Phe Leu Glu Val Lys Met Glu Asp Tyr Gly His Pro Phe Thr Cys His 
305                 310                 315                 320 


Ala Ala Val Ser Ala Ala Tyr Ile Ile Leu Lys Arg Pro Ala Pro Asp 
                325                 330                 335     


Phe Arg Ala Tyr Leu Ile Gly Gly Leu Met Ala Phe Leu Leu Leu Ala 
            340                 345                 350         


Val Ser Ile Leu Tyr Ile Tyr Asn Thr Phe Lys Val Asp Ile Val Leu 
        355                 360                 365             


Trp Tyr Arg Ser Thr Phe His Thr Ala Gln Ala Pro Asp Asp Glu Lys 
    370                 375                 380                 


Leu Tyr Asp Ala Tyr Val Leu Tyr Pro Lys Tyr Pro Arg Glu Ser Gln 
385                 390                 395                 400 


Gly His Asp Val Asp Thr Leu Val Leu Lys Ile Leu Pro Glu Val Leu 
                405                 410                 415     


Glu Lys Gln Cys Gly Tyr Lys Leu Phe Ile Phe Gly Arg Asp Glu Phe 
            420                 425                 430         


Pro Gly Gln Ala Val Ala Ser Val Ile Asp Glu Asn Ile Lys Leu Cys 
        435                 440                 445             


Arg Arg Leu Met Val Leu Val Ala Pro Glu Thr Ser Ser Phe Ser Phe 
    450                 455                 460                 


Leu Lys Asn Leu Thr Glu Glu Gln Ile Ala Val Tyr Asn Ala Leu Val 
465                 470                 475                 480 


Gln Asp Gly Met Lys Val Ile Leu Ile Glu Leu Glu Arg Val Lys Asp 
                485                 490                 495     


Tyr Ser Thr Met Pro Glu Ser Ile Gln Tyr Ile Arg Gln Lys His Gly 
            500                 505                 510         


Ala Ile Gln Trp Asp Gly Asp Phe Thr Glu Gln Ala Gln Cys Ala Lys 
        515                 520                 525             


Thr Lys Phe Trp Lys Lys Val Arg Tyr His Met Pro Pro Arg Arg Tyr 
    530                 535                 540                 


Pro Ala Ser Pro Pro Val Gln Leu Leu Gly His Thr Pro Arg Ile Pro 
545                 550                 555                 560 


Gly 
    


<210>  7
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Il1r12

<400>  7

Met Gly Val Thr Ser Leu Leu Phe Cys Gly Val Phe Phe Leu Leu Leu 
1               5                   10                  15      


Leu Phe Val Ala Ala Asp Gly Cys Lys Asp Ile Phe Met Lys Asn Glu 
            20                  25                  30          


Ile Leu Ser Ala Ser Gln Pro Phe Ala Phe Asn Cys Thr Phe Pro Pro 
        35                  40                  45              


Ile Thr Ser Gly Glu Val Ser Val Thr Trp Tyr Lys Asn Ser Ser Lys 
    50                  55                  60                  


Ile Pro Val Ser Lys Ile Ile Gln Ser Arg Ile His Gln Asp Glu Thr 
65                  70                  75                  80  


Trp Ile Leu Phe Leu Pro Met Glu Trp Gly Asp Ser Gly Val Tyr Gln 
                85                  90                  95      


Cys Val Ile Lys Gly Arg Asp Ser Cys His Arg Ile His Val Asn Leu 
            100                 105                 110         


Thr Val Phe Glu Lys His Trp Cys Asp Thr Ser Ile Gly Gly Leu Pro 
        115                 120                 125             


Asn Leu Ser Asp Glu Tyr Lys Gln Ile Leu His Leu Gly Lys Asp Asp 
    130                 135                 140                 


Ser Leu Thr Cys His Leu His Phe Pro Lys Ser Cys Val Leu Gly Pro 
145                 150                 155                 160 


Ile Lys Trp Tyr Lys Asp Cys Asn Glu Ile Lys Gly Glu Arg Phe Thr 
                165                 170                 175     


Val Leu Glu Thr Arg Leu Leu Val Ser Asn Val Ser Ala Glu Asp Arg 
            180                 185                 190         


Gly Asn Tyr Ala Cys Gln Ala Ile Leu Thr His Ser Gly Lys Gln Tyr 
        195                 200                 205             


Glu Val Leu Asn Gly Ile Thr Val Ser Ile Thr Glu Arg Ala Gly Tyr 
    210                 215                 220                 


Gly Gly Ser Val Pro Lys Ile Ile Tyr Pro Lys Asn His Ser Ile Glu 
225                 230                 235                 240 


Val Gln Leu Gly Thr Thr Leu Ile Val Asp Cys Asn Val Thr Asp Thr 
                245                 250                 255     


Lys Asp Asn Thr Asn Leu Arg Cys Trp Arg Val Asn Asn Thr Leu Val 
            260                 265                 270         


Asp Asp Tyr Tyr Asp Glu Ser Lys Arg Ile Arg Glu Gly Val Glu Thr 
        275                 280                 285             


His Val Ser Phe Arg Glu His Asn Leu Tyr Thr Val Asn Ile Thr Phe 
    290                 295                 300                 


Leu Glu Val Lys Met Glu Asp Tyr Gly Leu Pro Phe Met Cys His Ala 
305                 310                 315                 320 


Gly Val Ser Thr Ala Tyr Ile Ile Leu Gln Leu Pro Val Pro Asp Phe 
                325                 330                 335     


Arg Ala Tyr Leu Leu Gly Gly Leu Met Ala Phe Leu Leu Leu Val Val 
            340                 345                 350         


Ser Val Leu Phe Ile Tyr Asn Ser Phe Lys Ile Asp Ile Met Leu Trp 
        355                 360                 365             


Tyr Arg Ser Ala Phe His Thr Ala Gln Ala Pro Asp Asp Glu Lys Leu 
    370                 375                 380                 


Tyr Asp Ala Tyr Val Leu Tyr Pro Lys Tyr Pro Arg Gly Ser Gln Gly 
385                 390                 395                 400 


His Asp Val Asp Thr Leu Val Leu Lys Ile Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Phe Gly Arg Asp Glu Phe Pro 
            420                 425                 430         


Gly Gln Ala Val Ala Ser Val Ile Asp Glu Asn Ile Lys Leu Cys Arg 
        435                 440                 445             


Arg Leu Met Val Phe Val Ala Pro Glu Ser Ser Ser Phe Gly Phe Leu 
    450                 455                 460                 


Lys Asn Leu Ser Glu Glu Gln Ile Ala Val Tyr Asn Ala Leu Ile Gln 
465                 470                 475                 480 


His Gly Met Lys Val Ile Leu Ile Glu Leu Glu Lys Val Lys Asp Tyr 
                485                 490                 495     


Ser Thr Met Pro Glu Ser Ile Gln Tyr Ile Arg Gln Lys His Gly Ala 
            500                 505                 510         


Ile Gln Trp Asp Gly Asp Phe Thr Glu Gln Ser Gln Cys Ala Lys Thr 
        515                 520                 525             


Lys Phe Trp Lys Lys Val Arg Tyr His Met Pro Pro Arg Arg Tyr Pro 
    530                 535                 540                 


Ala Ser Ser Pro Val Gln Leu Leu Gly His Ile Pro Cys Asn Cys Lys 
545                 550                 555                 560 


Ala Gly Lys Cys Asn Ala Ala Thr Gly Leu Ile Thr Pro 
                565                 570             


<210>  8
<211>  888
<212>  DNA
<213>  Homo sapiens

<400>  8
aaaacccaag tgcagtagaa gccattgttc ataatggtag ggatacaggg tccttcgtaa       60

cagattatca gtgtggccta tgctggaaag tctggtgacc tctgattttt tttgcttcca      120

ggtctttggc cttggcactc tttgtcatat tagagttcct gggtctaggc ctgggcagga      180

ttcataggtg cagctgcttc tgctggaggt agactgcatc caacaaagta agggtgctgg      240

gtgagttctg ggagtataga ttctgactgg ggtcactgct gggctggccg ccagtctttc      300

atctgaccca gggttaaact gtggcttggg actgactcag gtcctctctt ggggtcggtc      360

tgcacataaa aggactccta tccttggcag ttctgaaaca acaccaccac aatggaaaaa      420

gcattgaaaa ttgacacacc tcagcagggg agcattcagg atatcaatca tcgggtgtgg      480

gttcttcagg accagacgct catagcagtc ccgaggaagg accgtatgtc tccagtcact      540

attgccttaa tctcatgccg acatgtggag acccttgaga aagacagagg gaaccccatc      600

tacctgggcc tgaatggact caatctctgc ctgatgtgtg ctaaagtcgg ggaccagccc      660

acactgcagc tgaaggaaaa ggatataatg gatttgtaca accaacccga gcctgtgaag      720

tcctttctct tctaccacag ccagagtggc aggaactcca ccttcgagtc tgtggctttc      780

cctggctggt tcatcgctgt cagctctgaa ggaggctgtc ctctcatcct tacccaagaa      840

ctggggaaag ccaacactac tgactttggg ttaactatgc tgttttaa                   888


<210>  9
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Lys Ala Leu Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln 
1               5                   10                  15      


Asp Ile Asn His Arg Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala 
            20                  25                  30          


Val Pro Arg Lys Asp Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser 
        35                  40                  45              


Cys Arg His Val Glu Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr 
    50                  55                  60                  


Leu Gly Leu Asn Gly Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly 
65                  70                  75                  80  


Asp Gln Pro Thr Leu Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr 
                85                  90                  95      


Asn Gln Pro Glu Pro Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser 
            100                 105                 110         


Gly Arg Asn Ser Thr Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile 
        115                 120                 125             


Ala Val Ser Ser Glu Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu 
    130                 135                 140                 


Gly Lys Ala Asn Thr Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150                 155             


<210>  10
<211>  883
<212>  DNA
<213>  Mus musculus

<400>  10
taacctcctc ttttcgtgtt gtggataaaa ggcttggacc ttagtagagc ttgtcagaga       60

agctgagcac agtagtgggt gtagttctgt agtgtgcaga cacattccta ttcaatcagg      120

gtcaatctgc agattggcag ctcagaaaca acatcaccat aatgaataag gagaaagaac      180

taagagcagc atcaccttcg cttagacatg ttcaggatct tagtagtcgt gtgtggatcc      240

tgcagaacaa tatcctcact gcagtcccaa ggaaagagca aacagttcca gtcactatta      300

ccttgctccc atgccaatat ctggacactc ttgagacgaa caggggggat cccacgtaca      360

tgggagtgca aaggccgatg agctgcctgt tctgcacaaa ggatggggag cagcctgtgc      420

tacagcttgg ggaagggaac ataatggaaa tgtacaacaa aaaggaacct gtaaaagcct      480

ctctcttcta tcacaagaag agtggtacaa cctctacatt tgagtctgca gccttccctg      540

gttggttcat cgctgtctgc tctaaaggga gctgcccact cattctgacc caagaactgg      600

gggaaatctt catcactgac ttcgagatga ttgtggtaca ttaaggtttt tagacacatt      660

gctctgtggc actctctcaa gatttcttgg attctaacaa gaagcaatca aagacacccc      720

taacaaaatg gaagactgaa aagaaagctg agccctccct gggctgtttt tccttggtgg      780

tgaatcagat gcagaacatc ttaccatgtt ttcatccaaa gcatttactg ttggttttta      840

caaggagtga attttttaaa ataaaatcat ttatctcatt tgc                        883


<210>  11
<211>  160
<212>  PRT
<213>  Mus musculus

<400>  11

Met Asn Lys Glu Lys Glu Leu Arg Ala Ala Ser Pro Ser Leu Arg His 
1               5                   10                  15      


Val Gln Asp Leu Ser Ser Arg Val Trp Ile Leu Gln Asn Asn Ile Leu 
            20                  25                  30          


Thr Ala Val Pro Arg Lys Glu Gln Thr Val Pro Val Thr Ile Thr Leu 
        35                  40                  45              


Leu Pro Cys Gln Tyr Leu Asp Thr Leu Glu Thr Asn Arg Gly Asp Pro 
    50                  55                  60                  


Thr Tyr Met Gly Val Gln Arg Pro Met Ser Cys Leu Phe Cys Thr Lys 
65                  70                  75                  80  


Asp Gly Glu Gln Pro Val Leu Gln Leu Gly Glu Gly Asn Ile Met Glu 
                85                  90                  95      


Met Tyr Asn Lys Lys Glu Pro Val Lys Ala Ser Leu Phe Tyr His Lys 
            100                 105                 110         


Lys Ser Gly Thr Thr Ser Thr Phe Glu Ser Ala Ala Phe Pro Gly Trp 
        115                 120                 125             


Phe Ile Ala Val Cys Ser Lys Gly Ser Cys Pro Leu Ile Leu Thr Gln 
    130                 135                 140                 


Glu Leu Gly Glu Ile Phe Ile Thr Asp Phe Glu Met Ile Val Val His 
145                 150                 155                 160 


<210>  12
<211>  869
<212>  DNA
<213>  Rattus norvegicus

<400>  12
taatctcctc ccttcatgtt ttggataaaa ggcctggacc ctagcagagc ttgtcagaga       60

agctgagcac agtagtggct gtagttctgt agtgtgcaga tacattcctc tgcaatcagg      120

atcagtctgc agattggcag ttcagaaaca acatcaccat aatgaataag gataaagaac      180

taagtgcagc aacaccttgg tttagacata ttcaggatct tagtagtcgt gtgtgggtcc      240

ttcaagacaa tattcttact gcagtcccaa ggaaagagca aacggttcca gtcactatca      300

ccttactccc atgccaatat ctggacactc ttgagaagaa caaaggggat cccatgtacc      360

tgggagtgaa gaaacctcaa agttgtctgt cctgcacaaa gaatggggag cagcctgtac      420

tacaacttcg ggaagggaac atactggata tgtaccacca gaaggaacgt gtaaaagcct      480

ctctcttcta tcacaagaag agtggtacaa cctctacatt cgagtctgca gccttccctg      540

gttggttcat tgctgtctgc tccaaaggga gctgcccact cgttttgacc caagaacttg      600

ggaaaacctt catcactgat tttgagatga ctgtagtaca ttaagattgc tctgcagcac      660

tctctgaaga tctctcggat tctaacaagc aaccaaacac acccccaaca aaatacaaga      720

ctgaaaagaa agctgagccc tccctgggct tttttccctt ggcaggtgga tcagatgcag      780

aacttcttac catgttttca tccaaagcat ttactgatgg tttttacaag aagaaaacgt      840

ttttaattaa aatcatttat ctcacttgc                                        869


<210>  13
<211>  160
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Asn Lys Asp Lys Glu Leu Ser Ala Ala Thr Pro Trp Phe Arg His 
1               5                   10                  15      


Ile Gln Asp Leu Ser Ser Arg Val Trp Val Leu Gln Asp Asn Ile Leu 
            20                  25                  30          


Thr Ala Val Pro Arg Lys Glu Gln Thr Val Pro Val Thr Ile Thr Leu 
        35                  40                  45              


Leu Pro Cys Gln Tyr Leu Asp Thr Leu Glu Lys Asn Lys Gly Asp Pro 
    50                  55                  60                  


Met Tyr Leu Gly Val Lys Lys Pro Gln Ser Cys Leu Ser Cys Thr Lys 
65                  70                  75                  80  


Asn Gly Glu Gln Pro Val Leu Gln Leu Arg Glu Gly Asn Ile Leu Asp 
                85                  90                  95      


Met Tyr His Gln Lys Glu Arg Val Lys Ala Ser Leu Phe Tyr His Lys 
            100                 105                 110         


Lys Ser Gly Thr Thr Ser Thr Phe Glu Ser Ala Ala Phe Pro Gly Trp 
        115                 120                 125             


Phe Ile Ala Val Cys Ser Lys Gly Ser Cys Pro Leu Val Leu Thr Gln 
    130                 135                 140                 


Glu Leu Gly Lys Thr Phe Ile Thr Asp Phe Glu Met Thr Val Val His 
145                 150                 155                 160 


<210>  14
<211>  1186
<212>  DNA
<213>  Homo sapiens

<400>  14
cacgggttcc tccccactct gtctttctca cctctccttc acttttccta gcctcctcac       60

caccatctga tctatcttgt tctcttcaca aaaggctctg aagacatcat gaacccacaa      120

cgggaggcag cacccaaatc ctatgctatt cgtgattctc gacagatggt gtgggtcctg      180

agtggaaatt ctttaatagc agctcctctt agccgcagca ttaagcctgt cactcttcat      240

ttaatagcct gtagagacac agaattcagt gacaaggaaa agggtaatat ggtttacctg      300

ggaatcaagg gaaaagatct ctgtctcttc tgtgcagaaa ttcagggcaa gcctactttg      360

cagcttaagc ttcagggctc ccaagataac atagggaagg acacttgctg gaaactagtt      420

ggaattcaca catgcataaa cctggatgtg agagagagct gcttcatggg aacccttgac      480

caatggggaa taggagtggg tagaaagaag tggaagagtt cctttcaaca tcaccatctc      540

aggaagaagg acaaagattt ctcatccatg cggaccaaca taggaatgcc aggaaggatg      600

tagaaataag gggaggaaga ttcccatctc tacaatcttt gagtgggttt gctatcaatg      660

aaatgctaca aatggaataa gttgcagaaa tttttctctt ttcttgggtt ctggagagtt      720

tgtaaaacaa ggacactatg tatttttaaa gagttggtaa atcttacctg taaagctaga      780

gaaggtcgga gtctttttag gagtagattt ggactacata acctgtaaat gtgttttgtc      840

cagtccttag agtgtttttt aaaaaattgt aaagtcaagg ttttcatgaa aaatgggaag      900

atcagacaac attgctcctg aattcccaca gagcagcaag ctactagagc tcaatctgtt      960

atttcttttc ctgatgtaca ggggttaagt cctatggaag aaacagcaga attattcaaa     1020

attatttaca taatgtgcaa ttattcacta gagcatgagg agtgaaacgc tctgtttagt     1080

atgtataact taaaaggaac acatacaatt aaaagtaatt gaaagacatt tcttcttaaa     1140

aattctataa tcttacactg gtaaaataaa ctagtttttc ccatgt                    1186


<210>  15
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asn Pro Gln Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp 
1               5                   10                  15      


Ser Arg Gln Met Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala 
            20                  25                  30          


Pro Leu Ser Arg Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys 
        35                  40                  45              


Arg Asp Thr Glu Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu 
    50                  55                  60                  


Gly Ile Lys Gly Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly 
65                  70                  75                  80  


Lys Pro Thr Leu Gln Leu Lys Leu Gln Gly Ser Gln Asp Asn Ile Gly 
                85                  90                  95      


Lys Asp Thr Cys Trp Lys Leu Val Gly Ile His Thr Cys Ile Asn Leu 
            100                 105                 110         


Asp Val Arg Glu Ser Cys Phe Met Gly Thr Leu Asp Gln Trp Gly Ile 
        115                 120                 125             


Gly Val Gly Arg Lys Lys Trp Lys Ser Ser Phe Gln His His His Leu 
    130                 135                 140                 


Arg Lys Lys Asp Lys Asp Phe Ser Ser Met Arg Thr Asn Ile Gly Met 
145                 150                 155                 160 


Pro Gly Arg Met 
                


<210>  16
<211>  790
<212>  DNA
<213>  Mus musculus

<400>  16
gactggcctc attgcctgct gtcataactt cgatcccaga gacaagactt ctttggacca       60

aggcaatgat ggctttccct ccacaatctt gtgtacatgt tcttcctcca aagagtattc      120

aaatgtggga accgaatcat aacactatgc atggatcctc acaatctccc agaaactaca      180

gggttcatga ctcacaacag atggtatggg tcctgactgg aaatacttta acagcagttc      240

ctgctagcaa caatgtcaag cctgtcattc ttagcttgat agcatgtaga gacacggaat      300

tccaagatgt aaagaaaggt aatctagttt tcctgggaat caagaacaga aatctctgct      360

tctgctgtgt tgagatggag ggcaaaccaa ctttgcagct taaggaagta gacatcatga      420

atttgtacaa agagagaaaa gcacaaaaag cctttctgtt ctatcatggc atagagggct      480

ccacttctgt ctttcagtca gtcctctatc ctggctggtt tatagccacc tcttccatag      540

aaagacagac aatcatcctc acacatcagc ggggtaaatt ggttaacact aacttctaca      600

tagagtctga gaagtaaatc caacatgggt catatgtggc cagctccagg ccacagaatc      660

aaactgttga agaatcttct acttgaaaac atagcaagcc tcttagaaga ccaccatgcc      720

atgtcttcac cagacatcca tgtctaaaat gccactcatt tgaatatcat tccagcatga      780

agcccatgaa                                                             790


<210>  17
<211>  183
<212>  PRT
<213>  Mus musculus

<400>  17

Met Met Ala Phe Pro Pro Gln Ser Cys Val His Val Leu Pro Pro Lys 
1               5                   10                  15      


Ser Ile Gln Met Trp Glu Pro Asn His Asn Thr Met His Gly Ser Ser 
            20                  25                  30          


Gln Ser Pro Arg Asn Tyr Arg Val His Asp Ser Gln Gln Met Val Trp 
        35                  40                  45              


Val Leu Thr Gly Asn Thr Leu Thr Ala Val Pro Ala Ser Asn Asn Val 
    50                  55                  60                  


Lys Pro Val Ile Leu Ser Leu Ile Ala Cys Arg Asp Thr Glu Phe Gln 
65                  70                  75                  80  


Asp Val Lys Lys Gly Asn Leu Val Phe Leu Gly Ile Lys Asn Arg Asn 
                85                  90                  95      


Leu Cys Phe Cys Cys Val Glu Met Glu Gly Lys Pro Thr Leu Gln Leu 
            100                 105                 110         


Lys Glu Val Asp Ile Met Asn Leu Tyr Lys Glu Arg Lys Ala Gln Lys 
        115                 120                 125             


Ala Phe Leu Phe Tyr His Gly Ile Glu Gly Ser Thr Ser Val Phe Gln 
    130                 135                 140                 


Ser Val Leu Tyr Pro Gly Trp Phe Ile Ala Thr Ser Ser Ile Glu Arg 
145                 150                 155                 160 


Gln Thr Ile Ile Leu Thr His Gln Arg Gly Lys Leu Val Asn Thr Asn 
                165                 170                 175     


Phe Tyr Ile Glu Ser Glu Lys 
            180             


<210>  18
<211>  587
<212>  DNA
<213>  Rattus norvegicus

<400>  18
ggcgtgggtc ctggctggaa attctttgac agcggttcct gctagcaaca gcgtcaaatc       60

tgtcattctt agcttgatag catgtagaga catggaattc caagatgaaa agaagggtaa      120

tctagttttc ctgggaatca aaggcagaag tctctgcctc ttctgtgctg agatcgaggg      180

caaaccgact ttgcagctta aggatgtaga catcatggat ttgtacaatg agaaaaaagc      240

acagaaagcc tttctcttct accatggcat agagggatct acttctgtct ttcagtcagt      300

cttgtatcct ggctggttta tagccacctc ttccacagca agacaaacaa tcattcttac      360

acaggagagg ggtgaagcta ataacactaa cttctactta gagtctgaga attagatcta      420

ccatgggcca tatgtggcca gttgcaggcc aaagaatcaa actgttggag aatcttttac      480

ttgaaaacat agcaagacat cttagaagac caccatgttt cctcttctcc tgacatccat      540

gtctgaaatg ccattcattg gtataagaga ataaaaaata gggctgg                    587


<210>  19
<211>  179
<212>  PRT
<213>  Rattus norvegicus

<400>  19

Met Met Ala Phe Pro Pro Gln Ser His Val Cys Phe Thr Pro Pro Lys 
1               5                   10                  15      


Ser Ser Asp Phe Asp Asn Ile Asn Lys Gly Val Gln Ala Phe Pro Ser 
            20                  25                  30          


Thr Tyr Arg Val His Asp Ser Gln His Lys Ala Trp Val Leu Ala Gly 
        35                  40                  45              


Asn Ser Leu Thr Ala Val Pro Ala Ser Asn Ser Val Lys Ser Val Ile 
    50                  55                  60                  


Leu Ser Leu Ile Ala Cys Arg Asp Met Glu Phe Gln Asp Glu Lys Lys 
65                  70                  75                  80  


Gly Asn Leu Val Phe Leu Gly Ile Lys Gly Arg Ser Leu Cys Leu Phe 
                85                  90                  95      


Cys Ala Glu Ile Glu Gly Lys Pro Thr Leu Gln Leu Lys Asp Val Asp 
            100                 105                 110         


Ile Met Asp Leu Tyr Asn Glu Lys Lys Ala Gln Lys Ala Phe Leu Phe 
        115                 120                 125             


Tyr His Gly Ile Glu Gly Ser Thr Ser Val Phe Gln Ser Val Leu Tyr 
    130                 135                 140                 


Pro Gly Trp Phe Ile Ala Thr Ser Ser Thr Ala Arg Gln Thr Ile Ile 
145                 150                 155                 160 


Leu Thr Gln Glu Arg Gly Glu Ala Asn Asn Thr Asn Phe Tyr Leu Glu 
                165                 170                 175     


Ser Glu Asn 
            


<210>  20
<211>  1212
<212>  DNA
<213>  Homo sapiens

<400>  20
gaagctgctg gagccacgat tcagtcccct ggactgtaga taaagaccct ttcttgccag       60

gtgctgagac aaccacacta tgagaggcac tccaggagac gctgatggtg gaggaagggc      120

cgtctatcaa tcaatgtgta aacctattac tgggactatt aatgatttga atcagcaagt      180

gtggaccctt cagggtcaga accttgtggc agttccacga agtgacagtg tgaccccagt      240

cactgttgct gttatcacat gcaagtatcc agaggctctt gagcaaggca gaggggatcc      300

catttatttg ggaatccaga atccagaaat gtgtttgtat tgtgagaagg ttggagaaca      360

gcccacattg cagctaaaag agcagaagat catggatctg tatggccaac ccgagcccgt      420

gaaacccttc cttttctacc gtgccaagac tggtaggacc tccacccttg agtctgtggc      480

cttcccggac tggttcattg cctcctccaa gagagaccag cccatcattc tgacttcaga      540

acttgggaag tcatacaaca ctgcctttga attaaatata aatgactgaa ctcagcctag      600

aggtggcagc ttggtctttg tcttaaagtt tctggttccc aatgtgtttt cgtctacatt      660

ttcttagtgt cattttcacg ctggtgctga gacaggggca aggctgctgt tatcatctca      720

ttttataatg aagaagaagc aattacttca tagcaactga agaacaggat gtggcctcag      780

aagcaggaga gctgggtggt ataaggctgt cctctcaagc tggtgctgtg taggccacaa      840

ggcatctgca tgagtgactt taagactcaa agaccaaaca ctgagctttc ttctaggggt      900

gggtatgaag atgcttcaga gctcatgcgc gttacccacg atggcatgac tagcacagag      960

ctgatctctg tttctgtttt gctttattcc ctcttgggat gatatcatcc agtctttata     1020

tgttgccaat atacctcatt gtgtgtaata gaaccttctt agcattaaga ccttgtaaac     1080

aaaaataatt cttgtgttaa gttaaatcat ttttgtccta attgtaatgt gtaatcttaa     1140

agttaaataa actttgtgta tttatataat aataaagcta aaactgatat aaaataaaga     1200

aagagtaaac tg                                                         1212


<210>  21
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Arg Gly Thr Pro Gly Asp Ala Asp Gly Gly Gly Arg Ala Val Tyr 
1               5                   10                  15      


Gln Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln 
            20                  25                  30          


Gln Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg Ser 
        35                  40                  45              


Asp Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro 
    50                  55                  60                  


Glu Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile Gln 
65                  70                  75                  80  


Asn Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro Thr 
                85                  90                  95      


Leu Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu 
            100                 105                 110         


Pro Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr Ser 
        115                 120                 125             


Thr Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser Lys 
    130                 135                 140                 


Arg Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn 
145                 150                 155                 160 


Thr Ala Phe Glu Leu Asn Ile Asn Asp 
                165                 


<210>  22
<211>  1647
<212>  DNA
<213>  Mus musculus

<400>  22
atcattacac ctgggagctg cccaagctgg gatttggtct tctagacttt ccataaggac       60

tctttcttgc catgtaccta caaacctaca aaaccctttg agtgcgcctc tgagtgtgga      120

gctttctgca gttcagggtt cagtgaatgg acagatctgt cttgctgtaa gtgatcctgt      180

gagcgatcct gtgagcgatc ctgtgagcga tcctgtgagc gatcctgtga gcgatcctgt      240

gagtgatcct gtgagcaatc ctgtgagagc tctgtgcacc agaacaagat cacgatggaa      300

aacaatgaaa aaaaaaacat tgtgtatgga agtgatgttg agatggaaca cgagagagct      360

gggctatttg tatcttcagc tatgttttct aaacacccat tttctacaca catctcagga      420

agagaaactc ctgactttgg ggaggttttt gacttggacc agcaggtgtg gatctttcgt      480

aatcaggccc ttgtgacagt tccacgaagc cacagagtaa ccccagtcag cgtgactatc      540

ctcccatgca agtacccaga gtctcttgaa caggacaaag ggattgccat ttatttggga      600

attcagaatc cagataaatg cctgttttgt aaggaagtta atggacaccc tactttgctg      660

ctaaaggaag agaagatttt ggatttgtac caccaccctg agccaatgaa gccattcctg      720

ttttaccaca cccggacagg tggaacatcc acctttgaat cagtggcttt ccctggccac      780

tatattgcct cctccaagac tggcaacccc atcttcctca catcaaaaaa gggagaatat      840

tacaacatta acttcaattt agatataaag tcttaaactc agcatggaag tggagggttg      900

gttagaactc ttcctcttaa aacatcaaac ctctaatatg ttatcatttg tttgatctat      960

ggtattttca tactgaaagg taagcaggac caacattatc tcctttcata gatgaagaag     1020

caacaaaata atgcatactc caaagtcggt gggattggag tggtgtaagg atgttctcta     1080

agactgaagt ggtccaatct ataagacatc atgtctgaga aatagggtgc tgtgccacag     1140

tgtataaaac ctagaatgcc ctgtgtgtga gtggtgacat cctcatttcc agccattggc     1200

ctgattcata ccatgttttc acacatttgt aatatcaact ccttgcattt ggatagcaga     1260

ggcctcacaa tgacatttgc ctcaacagct aatagctttg atctttcaat gctgtgtaga     1320

tctgaataca ctagaaaagg aattagaatc ctgagtgaat gaactgtgag gagccgccct     1380

cacatttgcc attataagat ggcactgaca gctgtgttct aagtggtaaa catagtctgc     1440

acacatgcag gggcagtttt cccaccatgt gttctgcctt tcccgtgatg acaactgggc     1500

cgatgggctg cagccaatca gggagtaata cgtcctaggt ggaggataat tctccttaaa     1560

agggacgggg ttctggcact ctctcccttc cttgcttgct ctcttgcact ctggctcctg     1620

aagatgtaag caataaagct ttgccgc                                         1647


<210>  23
<211>  164
<212>  PRT
<213>  Mus musculus

<400>  23

Met Phe Ser Lys His Pro Phe Ser Thr His Ile Ser Gly Arg Glu Thr 
1               5                   10                  15      


Pro Asp Phe Gly Glu Val Phe Asp Leu Asp Gln Gln Val Trp Ile Phe 
            20                  25                  30          


Arg Asn Gln Ala Leu Val Thr Val Pro Arg Ser His Arg Val Thr Pro 
        35                  40                  45              


Val Ser Val Thr Ile Leu Pro Cys Lys Tyr Pro Glu Ser Leu Glu Gln 
    50                  55                  60                  


Asp Lys Gly Ile Ala Ile Tyr Leu Gly Ile Gln Asn Pro Asp Lys Cys 
65                  70                  75                  80  


Leu Phe Cys Lys Glu Val Asn Gly His Pro Thr Leu Leu Leu Lys Glu 
                85                  90                  95      


Glu Lys Ile Leu Asp Leu Tyr His His Pro Glu Pro Met Lys Pro Phe 
            100                 105                 110         


Leu Phe Tyr His Thr Arg Thr Gly Gly Thr Ser Thr Phe Glu Ser Val 
        115                 120                 125             


Ala Phe Pro Gly His Tyr Ile Ala Ser Ser Lys Thr Gly Asn Pro Ile 
    130                 135                 140                 


Phe Leu Thr Ser Lys Lys Gly Glu Tyr Tyr Asn Ile Asn Phe Asn Leu 
145                 150                 155                 160 


Asp Ile Lys Ser 
                


<210>  24
<211>  1395
<212>  DNA
<213>  Rattus norvegicus

<400>  24
ggaagctgcc caagctggga tttgatcttc tgaactttcc ataaggactc tttcttgcca       60

ggcaccagaa caagctcatg atggaaaaca atgaaaaaaa tcgttacata tgggtgtgat      120

gttgagatgt gacactaacg aactgggcta tttgtatctt cagctatgtc ctctaaatac      180

ccacattctc catgtactgc ctcagcagga aaagaaactc ctgaccttgg gcaggtttct      240

gatgtggatc agcaggtgtg gatctttcgt gatcaggccc ttgtgacagt tccacgaagc      300

cacactgtaa ctccagtcac tgtgactgtc ctcccatgca agtacccaga gtctcttgag      360

cagggcaaag ggactcccat ttatttggga attcaaaatc cagataaatg cctgttttgt      420

aaggaagtta atggacaccc cactttgctc ctgaaggaag agaagatttt gaatttgtac      480

caccatcctg agccaatgaa gccattcctg ttttaccaca ccctgacagg tgcaacgtcc      540

acctttgaat cagtggtttt ccctggcagc tttattgcct cctccaagat tggcaaaccc      600

atcttcctca catcaaaaaa gggagaacat tacaacattc acttcagttt agatataatt      660

tagatataaa gtcttgaact cagaatggag gtggagggtt ggttagaact cttataactt      720

caaacctcta atatgctatc atttgtttga tgtgtggttg tttcatactg agaagtgagc      780

aaaaccaaca ttatctcatt tcatagatga agaagcaaca aaacagaatg tgtactccaa      840

agtaggttgg atgggagtgg tgtaaggctc tcctctaaga ctgaagtggt ccaacccata      900

aggcatcatg cctttctcag gtgctattat agggtgctgt gccacagtat ataaaaacta      960

gaatgcccca tgtgtgagta gcaacatcct cacttccagt cattggcctg attcatacca     1020

ggttttcaca cacttgtaat accaattcct tgcatttgga tagcaggagc ctcacaatga     1080

catttgctgc caacagctga tagctttgat ccttcagcaa ctgactgcta cgtggatctg     1140

aagacgccag aaaaggaatt agaatcctaa gtgaacgaac agtttttaaa atgtctagaa     1200

ctatttaaac tatgttagaa tacagtggtt tatccttgaa aggtaaggat actgcctggt     1260

aaatcaaaaa cagttaggtc aataaactca gcttgaacaa ttctttcctg gaaacaatgt     1320

gtacaagtaa tgattaaaac attacctttt attattctag acttccataa aaaaaaaaaa     1380

aaaaaaaaaa aaaaa                                                      1395


<210>  25
<211>  165
<212>  PRT
<213>  Rattus norvegicus

<400>  25

Met Ser Ser Lys Tyr Pro His Ser Pro Cys Thr Ala Ser Ala Gly Lys 
1               5                   10                  15      


Glu Thr Pro Asp Leu Gly Gln Val Ser Asp Val Asp Gln Gln Val Trp 
            20                  25                  30          


Ile Phe Arg Asp Gln Ala Leu Val Thr Val Pro Arg Ser His Thr Val 
        35                  40                  45              


Thr Pro Val Thr Val Thr Val Leu Pro Cys Lys Tyr Pro Glu Ser Leu 
    50                  55                  60                  


Glu Gln Gly Lys Gly Thr Pro Ile Tyr Leu Gly Ile Gln Asn Pro Asp 
65                  70                  75                  80  


Lys Cys Leu Phe Cys Lys Glu Val Asn Gly His Pro Thr Leu Leu Leu 
                85                  90                  95      


Lys Glu Glu Lys Ile Leu Asn Leu Tyr His His Pro Glu Pro Met Lys 
            100                 105                 110         


Pro Phe Leu Phe Tyr His Thr Leu Thr Gly Ala Thr Ser Thr Phe Glu 
        115                 120                 125             


Ser Val Val Phe Pro Gly Ser Phe Ile Ala Ser Ser Lys Ile Gly Lys 
    130                 135                 140                 


Pro Ile Phe Leu Thr Ser Lys Lys Gly Glu His Tyr Asn Ile His Phe 
145                 150                 155                 160 


Ser Leu Asp Ile Ile 
                165 


<210>  26
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  26
tacatttgaa ggtcttagca ttatgcttct aaatgactgg gctagtttgg gcgatcgcga       60

caagaagggt tgatttactc tgtaggtgag tacagagtaa agaactct                   108


<210>  27
<211>  140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  27
caccctgagc acatggggaa tccttcttgg gttgcaacat gtggaaggac ctcgagataa       60

cttcgtataa tgtatgctat acgaagttat atgcatggcc tccgcgccgg gttttggcgc      120

ctcccgcggg cgcccccctc                                                  140


<210>  28
<211>  181
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  28
tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga       60

ataacttcgt ataatgtatg ctatacgaag ttatgctagt aactataacg gtcctaaggt      120

agcgagctag ccagaatcaa tgacaaagat gaagaatata tttaacctca taaacttggt      180

t                                                                      181


<210>  29
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  29
caccctgagc acatggggaa tccttcttgg gttgcaacat gtggaaggac ctcgagataa       60

cttcgtataa tgtatgctat acgaagttat gctagtaact ataacggtcc taaggtagcg      120

agctagccag aatcaatgac aaagatgaag aatatattta acctcataaa cttggtt         177


<210>  30
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  30
ctggctctgt caactagatt ggaaggcatg cggagctgcc agtctcaact cgtcgacgtc       60

actctccttt cccactgcat gtgaagcatt tgagtgtctg                            100


<210>  31
<211>  140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  31
tgcactcaga aaagacaagt attcacattt tttcttgtgg ctgatctgga ctcgagataa       60

cttcgtataa tgtatgctat acgaagttat atgcatggcc tccgcgccgg gttttggcgc      120

ctcccgcggg cgcccccctc                                                  140


<210>  32
<211>  181
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  32
tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga       60

ataacttcgt ataatgtatg ctatacgaag ttatgctagt aactataacg gtcctaaggt      120

agcgagctag cctatgcctg cacagccctt ccataggtac taaggattta aactctcgtt      180

t                                                                      181


<210>  33
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  33
tgcactcaga aaagacaagt attcacattt tttcttgtgg ctgatctgga gtcgagataa       60

cttcgtataa tgtatgctat acgaagttat gctagtaact ataacggtcc taaggtagcg      120

agctagccta tgcctgcaca gcccttccat aggtactaag gatttaaact ctcgttt         177


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  34
gggtccatta tttgagactt tcca                                              24


<210>  35
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  35
agctttctgc tggccccatt acttg                                             25


<210>  36
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  36
gcatgtgcct gtcttcaca                                                    19


<210>  37
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  37
gagtggtaca acctctacat ttgag                                             25


<210>  38
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  38
ctgcagcctt ccctggttgg ttc                                               23


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  39
agtgggcagc tccctttaga                                                   20


<210>  40
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  40
cccactgcat gtgaagcat                                                    19


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  41
ttgagtgtct gcacctgagc ca                                                22


<210>  42
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  42
ggagacctct tattagcctg tga                                               23


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  43
cacctgccct aagtcatctc                                                   20


<210>  44
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  44
tacagcaaga gcagaggcca ca                                                22


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  45
gcctgcagag aagcaatgtt c                                                 21


<210>  46
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  46
cagccgctac acaccacaa                                                    19


<210>  47
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  47
ccagctgcta cacaaatgca gggc                                              24


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  48
cgtcatctcc tgccagttca                                                   20


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  49
ctgctgctca gagcattgaa a                                                 21


<210>  50
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  50
ccatggccag ggaaggctta cta                                               23


<210>  51
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  51
cgcctccgac tgaacatatg ac                                                22


<210>  52
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  52
cctgatatgc atctttccct atgga                                             25


<210>  53
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  53
atggcacctc agaccagacc cac                                               23


<210>  54
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  54
ggcagcaata atactgggac aaac                                              24


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  55
ggccaggaaa cacatctgaa g                                                 21


<210>  56
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  56
agcagtgact ctaaatgctc agtgtga                                           27


<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  57
gcctcactcc aacaacatta tga                                               23


