                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  Anti-IL36R Antibodies

<130>  36432PCT (10484WO01)

<150>  62/698,482
<151>  2018-07-16

<150>  62/846,989
<151>  2019-05-13

<150>  62/866,028
<151>  2019-06-25

<160>  240

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  1
gaagtgcagc tggtggagtc tgggggaggc ttggtgcagc ctggcaggtc cctgagactc       60

tcctgtgcgg cctctggatt cacctttgat gattatgcca tacactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcagtt atcagttgga atagtgatat cataggctat      180

gcggactctg tgaagggccg attcaccgtc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga atagtctgag aactgaggac acggccttgt attactgtgc aaaaggatat      300

aactggaact tctttgacta ttggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  2
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Trp Asn Ser Asp Ile Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Tyr Asn Trp Asn Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  3
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  3
ggattcacct ttgatgatta tgcc                                              24


<210>  4
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  5
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  5
atcagttgga atagtgatat cata                                              24


<210>  6
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Ser Trp Asn Ser Asp Ile Ile 
1               5               


<210>  7
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  7
gcaaaaggat ataactggaa cttctttgac tat                                    33


<210>  8
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Lys Gly Tyr Asn Trp Asn Phe Phe Asp Tyr 
1               5                   10      


<210>  9
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  9
gaaattgtgt tgacgcagtc tccagccacc ctgtctttat ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctataat gcagcaaaca gggccactga catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  10
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Ala Asn Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  11
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  11
cagagtgtta gcagctac                                                     18


<210>  12
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  13
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  13
aatgcagca                                                                9


<210>  14
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  14

Asn Ala Ala 
1           


<210>  15
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  15
cagcagcgta gcaactggcc tctcact                                           27


<210>  16
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  17
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  17
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaaact      120

ccagggaagg gcctggagtg ggtctcagtt attagttgga atagtgatgt catagcctat      180

tcggactctg tgaagggccg cttcaccatt tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctggg aactgaggac acggccttat attactgtgc aaaaggccat      300

aactggaact tctttgacta ttggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  18
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Trp Asn Ser Asp Val Ile Ala Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gly Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly His Asn Trp Asn Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  19
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  19
ggattcacct ttgatgatta tgcc                                              24


<210>  20
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  21
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  21
attagttgga atagtgatgt cata                                              24


<210>  22
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  22

Ile Ser Trp Asn Ser Asp Val Ile 
1               5               


<210>  23
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  23
gcaaaaggcc ataactggaa cttctttgac tat                                    33


<210>  24
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Lys Gly His Asn Trp Asn Phe Phe Asp Tyr 
1               5                   10      


<210>  25
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  25
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccaggaga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctataat gtagccaaca gggccacaga catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcgg cctagagcct      240

gaagattttg cagtttattt ctgtcagcag cgtagcaact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  26
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asn Val Ala Asn Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  27
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  27
cagagtgtta gcagctac                                                     18


<210>  28
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  29
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  29
aatgtagcc                                                                9


<210>  30
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  30

Asn Val Ala 
1           


<210>  31
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  31
cagcagcgta gcaactggcc tctcact                                           27


<210>  32
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  33
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  33
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtacag cctctggatt cacctttgat gattatgcca tacactgggt ccggcaatct      120

ccagggaagg gcctggagtg ggtctcagtt atcagttgga atagtgatgt cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcagatga atagtctgag agctgaggac acggccttgt attactgtgc aaaaggatat      300

aactggaact tctttgacta ttggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  34
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Trp Asn Ser Asp Val Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Tyr Asn Trp Asn Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  35
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  35
ggattcacct ttgatgatta tgcc                                              24


<210>  36
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  36

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  37
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  37
atcagttgga atagtgatgt cata                                              24


<210>  38
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  38

Ile Ser Trp Asn Ser Asp Val Ile 
1               5               


<210>  39
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  39
gcaaaaggat ataactggaa cttctttgac tat                                    33


<210>  40
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Lys Gly Tyr Asn Trp Asn Phe Phe Asp Tyr 
1               5                   10      


<210>  41
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  41
gaaattgtgt tgacgcagtc tccagccacc ctgtctttat ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctataat gcagcaaaca gggccactga catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  42
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Ala Asn Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  43
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  43
cagagtgtta gcagctac                                                     18


<210>  44
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  45
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  45
aatgcagca                                                                9


<210>  46
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  46

Asn Ala Ala 
1           


<210>  47
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  47
cagcagcgta gcaactggcc tctcact                                           27


<210>  48
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  49
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  49
gaagtgcagc tggtggagtc tgggggagac ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggaatg ggtctcagtt attagttgga atagtgatgt catagcctat      180

tcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag aactgaggac acggccttat attactgtac aaaaggccat      300

aagtggagct tctttgacta ttggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  50
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Trp Asn Ser Asp Val Ile Ala Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Gly His Lys Trp Ser Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  51
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  51
ggattcacct ttgatgatta tgcc                                              24


<210>  52
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  52

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  53
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  53
attagttgga atagtgatgt cata                                              24


<210>  54
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  54

Ile Ser Trp Asn Ser Asp Val Ile 
1               5               


<210>  55
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  55
acaaaaggcc ataagtggag cttctttgac tat                                    33


<210>  56
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  56

Thr Lys Gly His Lys Trp Ser Phe Phe Asp Tyr 
1               5                   10      


<210>  57
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  57
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtattagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccagactcct catctttaat gtagccaaca gggccactga catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  58
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  58

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Asn Val Ala Asn Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  59
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  59
cagagtatta gcagctac                                                     18


<210>  60
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  60

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  61
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  61
aatgtagcc                                                                9


<210>  62
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  62

Asn Val Ala 
1           


<210>  63
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  63
cagcagcgta gcaactggcc tctcact                                           27


<210>  64
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  65
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  65
gaggtgcagc tggtggagtc tgggggaggc ttggttcagc ctggggggtc cctgagactc       60

tcctgcgcag cctctggatt cacctttagc gactatgcca tgagctgggt ccgccaggct      120

ccggggaagg ggctggagtg ggtctcaggt attagtggaa atggtggtga cacatactac      180

ggagacttcg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag aggcgaggac acggccgcat atttctgtgt gatagatctt      300

gactattggg gtcagggaac cctggtcacc gtctcctca                             339


<210>  66
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Asn Gly Gly Asp Thr Tyr Tyr Gly Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ala Tyr Phe Cys 
                85                  90                  95      


Val Ile Asp Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  67
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  67
ggattcacct ttagcgacta tgcc                                              24


<210>  68
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  68

Gly Phe Thr Phe Ser Asp Tyr Ala 
1               5               


<210>  69
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  69
attagtggaa atggtggtga caca                                              24


<210>  70
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  70

Ile Ser Gly Asn Gly Gly Asp Thr 
1               5               


<210>  71
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  71
gtgatagatc ttgactat                                                     18


<210>  72
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  72

Val Ile Asp Leu Asp Tyr 
1               5       


<210>  73
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  73
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgaaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca acagaaacca      120

ggaaaagccc ctaggctcct gatctataag gcgtctattt taggagatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg ctacttatta ctgccaccag tataatagtt atttgtggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210>  74
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  74

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ile Leu Gly Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Asn Ser Tyr Leu Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  75
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  75
cagagtatta gtagctgg                                                     18


<210>  76
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  76

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  77
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  77
aaggcgtct                                                                9


<210>  78
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  78

Lys Ala Ser 
1           


<210>  79
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  79
caccagtata atagttattt gtggacg                                           27


<210>  80
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  80

His Gln Tyr Asn Ser Tyr Leu Trp Thr 
1               5                   


<210>  81
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  81
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtgctgatt actattggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt ggatccatct attatactgg gagtacttac      180

tacaacccgt ccctcaagag tcgacttacc atatcaatag acacgtctga gaaccagttc      240

tctttgaaac tgacctctct gactgccgcg gacacggccg tgtattactg tgcgagcgag      300

gaggctaact ggggatccca ctttgactcc tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  82
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  82

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ala 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Glu Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Glu Glu Ala Asn Trp Gly Ser His Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  83
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  83
ggtggctcca tcagcagtgc tgattactat                                        30


<210>  84
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  84

Gly Gly Ser Ile Ser Ser Ala Asp Tyr Tyr 
1               5                   10  


<210>  85
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  85
atctattata ctgggagtac t                                                 21


<210>  86
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  86

Ile Tyr Tyr Thr Gly Ser Thr 
1               5           


<210>  87
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  87
gcgagcgagg aggctaactg gggatcccac tttgactcc                              39


<210>  88
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  88

Ala Ser Glu Glu Ala Asn Trp Gly Ser His Phe Asp Ser 
1               5                   10              


<210>  89
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  89
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattgac aactttttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg catcttacta ctgtcaacat agtcacagtg cccatccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  90
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln His Ser His Ser Ala His Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  91
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  91
cagagcattg acaacttt                                                     18


<210>  92
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  92

Gln Ser Ile Asp Asn Phe 
1               5       


<210>  93
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  93
gctgcatcc                                                                9


<210>  94
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  94

Ala Ala Ser 
1           


<210>  95
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  95
caacatagtc acagtgccca tccgatcacc                                        30


<210>  96
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  96

Gln His Ser His Ser Ala His Pro Ile Thr 
1               5                   10  


<210>  97
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  97
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtagtaatt actactgggg ctggatccgc      120

cagcccccag ggaagagact ggagtggatt gggagtatct attatagtgg gagcacctac      180

tacaacccgt ccctcaagac tcgagtcacc atatccgtag acacgtccaa gaatcagttc      240

tccctgaagc tgacctctgt gaccgccgca gacacggctg tgtattactg tgcgagagag      300

gaagcagcag ctttgacgca ctttgacttc tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  98
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  98

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Arg Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Thr Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Glu Ala Ala Ala Leu Thr His Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  99
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  99
ggtggctcca tcagcagtag taattactac                                        30


<210>  100
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  100

Gly Gly Ser Ile Ser Ser Ser Asn Tyr Tyr 
1               5                   10  


<210>  101
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  101
atctattata gtgggagcac c                                                 21


<210>  102
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  102

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  103
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  103
gcgagagagg aagcagcagc tttgacgcac tttgacttc                              39


<210>  104
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  104

Ala Arg Glu Glu Ala Ala Ala Leu Thr His Phe Asp Phe 
1               5                   10              


<210>  105
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  105
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctttgct gcatccagtt tacaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacat agtcacagtt cccatccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  106
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser His Ser Ser His Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  107
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  107
cagagcatta gcaactat                                                     18


<210>  108
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  108

Gln Ser Ile Ser Asn Tyr 
1               5       


<210>  109
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  109
gctgcatcc                                                                9


<210>  110
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  110

Ala Ala Ser 
1           


<210>  111
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  111
caacatagtc acagttccca tccgatcacc                                        30


<210>  112
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  112

Gln His Ser His Ser Ser His Pro Ile Thr 
1               5                   10  


<210>  113
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  113
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attaattggg ctggttataa catagactat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatatg      300

cgtggattca gttatggttt cccctttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  114
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Ala Gly Tyr Asn Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Met Arg Gly Phe Ser Tyr Gly Phe Pro Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  115
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  115
ggattcacct ttgatgatta tgcc                                              24


<210>  116
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  116

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  117
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  117
attaattggg ctggttataa cata                                              24


<210>  118
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  118

Ile Asn Trp Ala Gly Tyr Asn Ile 
1               5               


<210>  119
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  119
gcaaaagata tgcgtggatt cagttatggt ttcccctttg actac                       45


<210>  120
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  120

Ala Lys Asp Met Arg Gly Phe Ser Tyr Gly Phe Pro Phe Asp Tyr 
1               5                   10                  15  


<210>  121
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  121
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  122
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  122

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  123
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  123
cagagcatta gcagctat                                                     18


<210>  124
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  124

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  125
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  125
gctgcatcc                                                                9


<210>  126
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  126

Ala Ala Ser 
1           


<210>  127
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  127
caacagagtt acagtacccc tccgatcacc                                        30


<210>  128
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  128

Gln Gln Ser Tyr Ser Thr Pro Pro Ile Thr 
1               5                   10  


<210>  129
<211>  399
<212>  DNA
<213>  Homo sapiens

<400>  129
gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc cgggggggtc ccttagactc       60

tcctgtgcag cctctggatt tattttcagt aacgcctgga tgaactgggt ccgccaggct      120

ccagggaagg gactggcgtg ggttggccgt attaaaaccg aaactgatgg tgggacaaca      180

gactacgctg cacccgtaaa aggcagattc accatctcaa gagatgactc aaaaaacacg      240

ctgtatctgc aaatgaacag cgtgaaaacc gaggacacag ccgtgtatta ctgtacaggg      300

ggatacagct atggtgacga tagcagcagc tggaacgagg gctactacta ctacggtatg      360

gacgtctggg gccaagggac cacggtcacc gtctcctca                             399


<210>  130
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  130

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Thr Glu Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Val Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Gly Tyr Ser Tyr Gly Asp Asp Ser Ser Ser Trp Asn 
            100                 105                 110         


Glu Gly Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  131
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  131
ggatttattt tcagtaacgc ctgg                                              24


<210>  132
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  132

Gly Phe Ile Phe Ser Asn Ala Trp 
1               5               


<210>  133
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  133
attaaaaccg aaactgatgg tgggacaaca                                        30


<210>  134
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  134

Ile Lys Thr Glu Thr Asp Gly Gly Thr Thr 
1               5                   10  


<210>  135
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  135
acagggggat acagctatgg tgacgatagc agcagctgga acgagggcta ctactactac       60

ggtatggacg tc                                                           72


<210>  136
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  136

Thr Gly Gly Tyr Ser Tyr Gly Asp Asp Ser Ser Ser Trp Asn Glu Gly 
1               5                   10                  15      


Tyr Tyr Tyr Tyr Gly Met Asp Val 
            20                  


<210>  137
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  137
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtacag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attcgttgga atggtggtag tataggctat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa gtccctgcat      240

ctgcaaatga acagtctaaa aactgaggac acggccttgt attactgtgc aaaagatata      300

ggcgatattt tgactggttt ttatggagaa tacggaatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210>  138
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  138

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Trp Asn Gly Gly Ser Ile Gly Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Gly Asp Ile Leu Thr Gly Phe Tyr Gly Glu Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  139
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  139
ggattcacct ttgatgatta tgcc                                              24


<210>  140
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  140

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  141
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  141
attcgttgga atggtggtag tata                                              24


<210>  142
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  142

Ile Arg Trp Asn Gly Gly Ser Ile 
1               5               


<210>  143
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  143
gcaaaagata taggcgatat tttgactggt ttttatggag aatacggaat ggacgtc          57


<210>  144
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  144

Ala Lys Asp Ile Gly Asp Ile Leu Thr Gly Phe Tyr Gly Glu Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  145
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  145
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgaaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaagca      120

gggaaagccc ctaacctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagag tacactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacatta tcccgtacac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  146
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  146

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Ala Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ile Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  147
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  147
cagagcatta gcagctat                                                     18


<210>  148
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  148

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  149
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  149
gctgcatcc                                                                9


<210>  150
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  150

Ala Ala Ser 
1           


<210>  151
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  151
caacagagtt acattatccc gtacact                                           27


<210>  152
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  152

Gln Gln Ser Tyr Ile Ile Pro Tyr Thr 
1               5                   


<210>  153
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  153
gaagtgcagc tggtggagtc tgggggaggg ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaagt gttaggtgga atggtggtat tataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag acctgaggac acggccctct attactgtgc aaaagatata      300

ggcgatgttt tgactggtta ttatggagaa tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210>  154
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  154

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Val Arg Trp Asn Gly Gly Ile Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Gly Asp Val Leu Thr Gly Tyr Tyr Gly Glu Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  155
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  155
ggattcacct ttgatgatta tgcc                                              24


<210>  156
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  156

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  157
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  157
gttaggtgga atggtggtat tata                                              24


<210>  158
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  158

Val Arg Trp Asn Gly Gly Ile Ile 
1               5               


<210>  159
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  159
gcaaaagata taggcgatgt tttgactggt tattatggag aatacggtat ggacgtc          57


<210>  160
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  160

Ala Lys Asp Ile Gly Asp Val Leu Thr Gly Tyr Tyr Gly Glu Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  161
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  161
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcgcttgcc gggcaagtca gagcattacc acctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagtag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacattt ccccgtacac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  162
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  162

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Gln Ser Ile Thr Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ile Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  163
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  163
cagagcatta ccacctat                                                     18


<210>  164
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  164

Gln Ser Ile Thr Thr Tyr 
1               5       


<210>  165
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  165
gctgcatcc                                                                9


<210>  166
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  166

Ala Ala Ser 
1           


<210>  167
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  167
caacagagtt acatttcccc gtacact                                           27


<210>  168
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  168

Gln Gln Ser Tyr Ile Ser Pro Tyr Thr 
1               5                   


<210>  169
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  169
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaagtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aattatggca tacactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcgatt atattatatg atggaagtaa tcaacactat      180

gcagattccg tgaagggccg attcaccatt tccagagaca attccaaaaa cacgctgtat      240

cttcaaatga acaacctgag agctgaggac acggccgttt attactgtgc gagagatctt      300

gatctttgga gtggttatta tacaaacggg gacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210>  170
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  170

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Leu Tyr Asp Gly Ser Asn Gln His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Asp Leu Trp Ser Gly Tyr Tyr Thr Asn Gly Asp Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  171
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  171
ggattcacct tcagtaatta tggc                                              24


<210>  172
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  172

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  173
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  173
atattatatg atggaagtaa tcaa                                              24


<210>  174
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  174

Ile Leu Tyr Asp Gly Ser Asn Gln 
1               5               


<210>  175
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  175
gcgagagatc ttgatctttg gagtggttat tatacaaacg gggacggtat ggacgtc          57


<210>  176
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  176

Ala Arg Asp Leu Asp Leu Trp Ser Gly Tyr Tyr Thr Asn Gly Asp Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  177
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Trp Ser Leu Leu Leu Cys Gly Leu Ser Ile Ala Leu Pro Leu Ser 
1               5                   10                  15      


Val Thr Ala Asp Gly Cys Lys Asp Ile Phe Met Lys Asn Glu Ile Leu 
            20                  25                  30          


Ser Ala Ser Gln Pro Phe Ala Phe Asn Cys Thr Phe Pro Pro Ile Thr 
        35                  40                  45              


Ser Gly Glu Val Ser Val Thr Trp Tyr Lys Asn Ser Ser Lys Ile Pro 
    50                  55                  60                  


Val Ser Lys Ile Ile Gln Ser Arg Ile His Gln Asp Glu Thr Trp Ile 
65                  70                  75                  80  


Leu Phe Leu Pro Met Glu Trp Gly Asp Ser Gly Val Tyr Gln Cys Val 
                85                  90                  95      


Ile Lys Gly Arg Asp Ser Cys His Arg Ile His Val Asn Leu Thr Val 
            100                 105                 110         


Phe Glu Lys His Trp Cys Asp Thr Ser Ile Gly Gly Leu Pro Asn Leu 
        115                 120                 125             


Ser Asp Glu Tyr Lys Gln Ile Leu His Leu Gly Lys Asp Asp Ser Leu 
    130                 135                 140                 


Thr Cys His Leu His Phe Pro Lys Ser Cys Val Leu Gly Pro Ile Lys 
145                 150                 155                 160 


Trp Tyr Lys Asp Cys Asn Glu Ile Lys Gly Glu Arg Phe Thr Val Leu 
                165                 170                 175     


Glu Thr Arg Leu Leu Val Ser Asn Val Ser Ala Glu Asp Arg Gly Asn 
            180                 185                 190         


Tyr Ala Cys Gln Ala Ile Leu Thr His Ser Gly Lys Gln Tyr Glu Val 
        195                 200                 205             


Leu Asn Gly Ile Thr Val Ser Ile Thr Glu Arg Ala Gly Tyr Gly Gly 
    210                 215                 220                 


Ser Val Pro Lys Ile Ile Tyr Pro Lys Asn His Ser Ile Glu Val Gln 
225                 230                 235                 240 


Leu Gly Thr Thr Leu Ile Val Asp Cys Asn Val Thr Asp Thr Lys Asp 
                245                 250                 255     


Asn Thr Asn Leu Arg Cys Trp Arg Val Asn Asn Thr Leu Val Asp Asp 
            260                 265                 270         


Tyr Tyr Asp Glu Ser Lys Arg Ile Arg Glu Gly Val Glu Thr His Val 
        275                 280                 285             


Ser Phe Arg Glu His Asn Leu Tyr Thr Val Asn Ile Thr Phe Leu Glu 
    290                 295                 300                 


Val Lys Met Glu Asp Tyr Gly Leu Pro Phe Met Cys His Ala Gly Val 
305                 310                 315                 320 


Ser Thr Ala Tyr Ile Ile Leu Gln Leu Pro Ala Pro Asp Phe Arg Ala 
                325                 330                 335     


Tyr Leu Ile Gly Gly Leu Ile Ala Leu Val Ala Val Ala Val Ser Val 
            340                 345                 350         


Val Tyr Ile Tyr Asn Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Ser Ala Phe His Ser Thr Glu Thr Ile Val Asp Gly Lys Leu Tyr Asp 
    370                 375                 380                 


Ala Tyr Val Leu Tyr Pro Lys Pro His Lys Glu Ser Gln Arg His Ala 
385                 390                 395                 400 


Val Asp Ala Leu Val Leu Asn Ile Leu Pro Glu Val Leu Glu Arg Gln 
                405                 410                 415     


Cys Gly Tyr Lys Leu Phe Ile Phe Gly Arg Asp Glu Phe Pro Gly Gln 
            420                 425                 430         


Ala Val Ala Asn Val Ile Asp Glu Asn Val Lys Leu Cys Arg Arg Leu 
        435                 440                 445             


Ile Val Ile Val Val Pro Glu Ser Leu Gly Phe Gly Leu Leu Lys Asn 
    450                 455                 460                 


Leu Ser Glu Glu Gln Ile Ala Val Tyr Ser Ala Leu Ile Gln Asp Gly 
465                 470                 475                 480 


Met Lys Val Ile Leu Ile Glu Leu Glu Lys Ile Glu Asp Tyr Thr Val 
                485                 490                 495     


Met Pro Glu Ser Ile Gln Tyr Ile Lys Gln Lys His Gly Ala Ile Arg 
            500                 505                 510         


Trp His Gly Asp Phe Thr Glu Gln Ser Gln Cys Met Lys Thr Lys Phe 
        515                 520                 525             


Trp Lys Thr Val Arg Tyr His Met Pro Pro Arg Arg Cys Arg Pro Phe 
    530                 535                 540                 


Pro Pro Val Gln Leu Leu Gln His Thr Pro Cys Tyr Arg Thr Ala Gly 
545                 550                 555                 560 


Pro Glu Leu Gly Ser Arg Arg Lys Lys Cys Thr Leu Thr Thr Gly 
                565                 570                 575 


<210>  178
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
    450                 455                 460                 


Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                485                 490                 495     


Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
            500                 505                 510         


Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
        515                 520                 525             


Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
    530                 535                 540                 


Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
545                 550                 555                 560 


Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                565                 570 


<210>  179
<211>  1338
<212>  DNA
<213>  Homo sapiens

<400>  179
gaagtgcagc tggtggagtc tgggggaggc ttggtgcagc ctggcaggtc cctgagactc       60

tcctgtgcgg cctctggatt cacctttgat gattatgcca tacactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcagtt atcagttgga atagtgatat cataggctat      180

gcggactctg tgaagggccg attcaccgtc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga atagtctgag aactgaggac acggccttgt attactgtgc aaaaggatat      300

aactggaact tctttgacta ttggggccag ggaaccctgg tcaccgtctc ctcagcctcc      360

accaagggcc catcggtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca      420

gccgccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcacgaa gacctacacc      600

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agagagttga gtccaaatat      660

ggtcccccat gcccaccctg cccagcacct gagttcctgg ggggaccatc agtcttcctg      720

ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg      780

gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      960

gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcag gctcaccgtg gacaagagca ggtggcagga ggggaatgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa gtccctctcc     1320

ctgtctctgg gtaaatga                                                   1338


<210>  180
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Trp Asn Ser Asp Ile Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Tyr Asn Trp Asn Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  181
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  181
gaaattgtgt tgacgcagtc tccagccacc ctgtctttat ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctataat gcagcaaaca gggccactga catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  182
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  182

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Ala Asn Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  183
<211>  1338
<212>  DNA
<213>  Homo sapiens

<400>  183
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaaact      120

ccagggaagg gcctggagtg ggtctcagtt attagttgga atagtgatgt catagcctat      180

tcggactctg tgaagggccg cttcaccatt tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctggg aactgaggac acggccttat attactgtgc aaaaggccat      300

aactggaact tctttgacta ttggggccag ggaaccctgg tcaccgtctc ctcagcctcc      360

accaagggcc catcggtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca      420

gccgccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcacgaa gacctacacc      600

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agagagttga gtccaaatat      660

ggtcccccat gcccaccctg cccagcacct gagttcctgg ggggaccatc agtcttcctg      720

ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg      780

gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      960

gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcag gctcaccgtg gacaagagca ggtggcagga ggggaatgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa gtccctctcc     1320

ctgtctctgg gtaaatga                                                   1338


<210>  184
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  184

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Trp Asn Ser Asp Val Ile Ala Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gly Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly His Asn Trp Asn Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  185
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  185
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccaggaga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctataat gtagccaaca gggccacaga catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcgg cctagagcct      240

gaagattttg cagtttattt ctgtcagcag cgtagcaact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  186
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  186

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asn Val Ala Asn Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  187
<211>  1338
<212>  DNA
<213>  Homo sapiens

<400>  187
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtacag cctctggatt cacctttgat gattatgcca tacactgggt ccggcaatct      120

ccagggaagg gcctggagtg ggtctcagtt atcagttgga atagtgatgt cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcagatga atagtctgag agctgaggac acggccttgt attactgtgc aaaaggatat      300

aactggaact tctttgacta ttggggccag ggaaccctgg tcaccgtctc ctcagcctcc      360

accaagggcc catcggtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca      420

gccgccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcacgaa gacctacacc      600

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agagagttga gtccaaatat      660

ggtcccccat gcccaccctg cccagcacct gagttcctgg ggggaccatc agtcttcctg      720

ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg      780

gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      960

gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcag gctcaccgtg gacaagagca ggtggcagga ggggaatgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa gtccctctcc     1320

ctgtctctgg gtaaatga                                                   1338


<210>  188
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  188

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Trp Asn Ser Asp Val Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Tyr Asn Trp Asn Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  189
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  189
gaaattgtgt tgacgcagtc tccagccacc ctgtctttat ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctataat gcagcaaaca gggccactga catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  190
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  190

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Ala Asn Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  191
<211>  1338
<212>  DNA
<213>  Homo sapiens

<400>  191
gaagtgcagc tggtggagtc tgggggagac ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggaatg ggtctcagtt attagttgga atagtgatgt catagcctat      180

tcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag aactgaggac acggccttat attactgtac aaaaggccat      300

aagtggagct tctttgacta ttggggccag ggaaccctgg tcaccgtctc ctcagcctcc      360

accaagggcc catcggtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca      420

gccgccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcacgaa gacctacacc      600

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agagagttga gtccaaatat      660

ggtcccccat gcccaccctg cccagcacct gagttcctgg ggggaccatc agtcttcctg      720

ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg      780

gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      960

gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcag gctcaccgtg gacaagagca ggtggcagga ggggaatgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa gtccctctcc     1320

ctgtctctgg gtaaatga                                                   1338


<210>  192
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  192

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Trp Asn Ser Asp Val Ile Ala Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Gly His Lys Trp Ser Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  193
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  193
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtattagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccagactcct catctttaat gtagccaaca gggccactga catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  194
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  194

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Asn Val Ala Asn Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  195
<211>  1323
<212>  DNA
<213>  Homo sapiens

<400>  195
gaggtgcagc tggtggagtc tgggggaggc ttggttcagc ctggggggtc cctgagactc       60

tcctgcgcag cctctggatt cacctttagc gactatgcca tgagctgggt ccgccaggct      120

ccggggaagg ggctggagtg ggtctcaggt attagtggaa atggtggtga cacatactac      180

ggagacttcg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag aggcgaggac acggccgcat atttctgtgt gatagatctt      300

gactattggg gtcagggaac cctggtcacc gtctcctcag cctccaccaa gggcccatcg      360

gtcttccccc tggcgccctg ctccaggagc acctccgaga gcacagccgc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acgaagacct acacctgcaa cgtagatcac      600

aagcccagca acaccaaggt ggacaagaga gttgagtcca aatatggtcc cccatgccca      660

ccctgcccag cacctgagtt cctgggggga ccatcagtct tcctgttccc cccaaaaccc      720

aaggacactc tcatgatctc ccggacccct gaggtcacgt gcgtggtggt ggacgtgagc      780

caggaagacc ccgaggtcca gttcaactgg tacgtggatg gcgtggaggt gcataatgcc      840

aagacaaagc cgcgggagga gcagttcaac agcacgtacc gtgtggtcag cgtcctcacc      900

gtcctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtctc caacaaaggc      960

ctcccgtcct ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agagccacag     1020

gtgtacaccc tgcccccatc ccaggaggag atgaccaaga accaggtcag cctgacctgc     1080

ctggtcaaag gcttctaccc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1140

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1200

agcaggctca ccgtggacaa gagcaggtgg caggagggga atgtcttctc atgctccgtg     1260

atgcatgagg ctctgcacaa ccactacaca cagaagtccc tctccctgtc tctgggtaaa     1320

tga                                                                   1323


<210>  196
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  196

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Asn Gly Gly Asp Thr Tyr Tyr Gly Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ala Tyr Phe Cys 
                85                  90                  95      


Val Ile Asp Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210>  197
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  197
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgaaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca acagaaacca      120

ggaaaagccc ctaggctcct gatctataag gcgtctattt taggagatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg ctacttatta ctgccaccag tataatagtt atttgtggac gttcggccaa      300

gggaccaagg tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  198
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  198

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ile Leu Gly Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Asn Ser Tyr Leu Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  199
<211>  1347
<212>  DNA
<213>  Homo sapiens

<400>  199
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtgctgatt actattggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt ggatccatct attatactgg gagtacttac      180

tacaacccgt ccctcaagag tcgacttacc atatcaatag acacgtctga gaaccagttc      240

tctttgaaac tgacctctct gactgccgcg gacacggccg tgtattactg tgcgagcgag      300

gaggctaact ggggatccca ctttgactcc tggggccagg gaaccctggt caccgtctcc      360

tcagcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag      660

tccaaatatg gtcccccatg cccaccctgc ccagcacctg agttcctggg gggaccatca      720

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc      780

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg      840

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac      960

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcagg ctcaccgtgg acaagagcag gtggcaggag     1260

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag     1320

tccctctccc tgtctctggg taaatga                                         1347


<210>  200
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  200

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ala 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Glu Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Glu Glu Ala Asn Trp Gly Ser His Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210>  201
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  201
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattgac aactttttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg catcttacta ctgtcaacat agtcacagtg cccatccgat caccttcggc      300

caagggacac gactggagat taaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  202
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  202

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln His Ser His Ser Ala His Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  203
<211>  1347
<212>  DNA
<213>  Homo sapiens

<400>  203
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtagtaatt actactgggg ctggatccgc      120

cagcccccag ggaagagact ggagtggatt gggagtatct attatagtgg gagcacctac      180

tacaacccgt ccctcaagac tcgagtcacc atatccgtag acacgtccaa gaatcagttc      240

tccctgaagc tgacctctgt gaccgccgca gacacggctg tgtattactg tgcgagagag      300

gaagcagcag ctttgacgca ctttgacttc tggggccagg gaaccctggt caccgtctcc      360

tcagcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag      660

tccaaatatg gtcccccatg cccaccctgc ccagcacctg agttcctggg gggaccatca      720

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc      780

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg      840

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac      960

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcagg ctcaccgtgg acaagagcag gtggcaggag     1260

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag     1320

tccctctccc tgtctctggg taaatga                                         1347


<210>  204
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  204

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Arg Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Thr Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Glu Ala Ala Ala Leu Thr His Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210>  205
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  205
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctttgct gcatccagtt tacaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacat agtcacagtt cccatccgat caccttcggc      300

caagggacac gactggagat taaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  206
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  206

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser His Ser Ser His Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  207
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  207
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attaattggg ctggttataa catagactat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatatg      300

cgtggattca gttatggttt cccctttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctcagcct ccaccaaggg cccatcggtc ttccccctgg cgccctgctc caggagcacc      420

tccgagagca cagccgccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacg      600

aagacctaca cctgcaacgt agatcacaag cccagcaaca ccaaggtgga caagagagtt      660

gagtccaaat atggtccccc atgcccaccc tgcccagcac ctgagttcct ggggggacca      720

tcagtcttcc tgttcccccc aaaacccaag gacactctca tgatctcccg gacccctgag      780

gtcacgtgcg tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac      840

gtggatggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag      960

tacaagtgca aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga gccacaggtg tacaccctgc ccccatccca ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aggctcaccg tggacaagag caggtggcag     1260

gaggggaatg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacacag     1320

aagtccctct ccctgtctct gggtaaatga                                      1350


<210>  208
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  208

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Ala Gly Tyr Asn Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Met Arg Gly Phe Ser Tyr Gly Phe Pro Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             


Lys 
    


<210>  209
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  209
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccgat caccttcggc      300

caagggacac gactggagat taaaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      645


<210>  210
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  210

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  211
<211>  1383
<212>  DNA
<213>  Homo sapiens

<400>  211
gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc cgggggggtc ccttagactc       60

tcctgtgcag cctctggatt tattttcagt aacgcctgga tgaactgggt ccgccaggct      120

ccagggaagg gactggcgtg ggttggccgt attaaaaccg aaactgatgg tgggacaaca      180

gactacgctg cacccgtaaa aggcagattc accatctcaa gagatgactc aaaaaacacg      240

ctgtatctgc aaatgaacag cgtgaaaacc gaggacacag ccgtgtatta ctgtacaggg      300

ggatacagct atggtgacga tagcagcagc tggaacgagg gctactacta ctacggtatg      360

gacgtctggg gccaagggac cacggtcacc gtctcctcag cctccaccaa gggcccatcg      420

gtcttccccc tggcgccctg ctccaggagc acctccgaga gcacagccgc cctgggctgc      480

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      540

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      600

gtggtgaccg tgccctccag cagcttgggc acgaagacct acacctgcaa cgtagatcac      660

aagcccagca acaccaaggt ggacaagaga gttgagtcca aatatggtcc cccatgccca      720

ccctgcccag cacctgagtt cctgggggga ccatcagtct tcctgttccc cccaaaaccc      780

aaggacactc tcatgatctc ccggacccct gaggtcacgt gcgtggtggt ggacgtgagc      840

caggaagacc ccgaggtcca gttcaactgg tacgtggatg gcgtggaggt gcataatgcc      900

aagacaaagc cgcgggagga gcagttcaac agcacgtacc gtgtggtcag cgtcctcacc      960

gtcctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtctc caacaaaggc     1020

ctcccgtcct ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agagccacag     1080

gtgtacaccc tgcccccatc ccaggaggag atgaccaaga accaggtcag cctgacctgc     1140

ctggtcaaag gcttctaccc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1200

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1260

agcaggctca ccgtggacaa gagcaggtgg caggagggga atgtcttctc atgctccgtg     1320

atgcatgagg ctctgcacaa ccactacaca cagaagtccc tctccctgtc tctgggtaaa     1380

tga                                                                   1383


<210>  212
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  212

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Thr Glu Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Val Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Gly Tyr Ser Tyr Gly Asp Asp Ser Ser Ser Trp Asn 
            100                 105                 110         


Glu Gly Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
        355                 360                 365             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460 


<210>  213
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  213
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccgat caccttcggc      300

caagggacac gactggagat taaaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      645


<210>  214
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  214

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  215
<211>  1362
<212>  DNA
<213>  Homo sapiens

<400>  215
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtacag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attcgttgga atggtggtag tataggctat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa gtccctgcat      240

ctgcaaatga acagtctaaa aactgaggac acggccttgt attactgtgc aaaagatata      300

ggcgatattt tgactggttt ttatggagaa tacggaatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctcagc ctccaccaag ggcccatcgg tcttccccct ggcgccctgc      420

tccaggagca cctccgagag cacagccgcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cgaagaccta cacctgcaac gtagatcaca agcccagcaa caccaaggtg      660

gacaagagag ttgagtccaa atatggtccc ccatgcccac cctgcccagc acctgagttc      720

ctggggggac catcagtctt cctgttcccc ccaaaaccca aggacactct catgatctcc      780

cggacccctg aggtcacgtg cgtggtggtg gacgtgagcc aggaagaccc cgaggtccag      840

ttcaactggt acgtggatgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagttcaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aacggcaagg agtacaagtg caaggtctcc aacaaaggcc tcccgtcctc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gagccacagg tgtacaccct gcccccatcc     1080

caggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctacccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaggctcac cgtggacaag     1260

agcaggtggc aggaggggaa tgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacac agaagtccct ctccctgtct ctgggtaaat ga                        1362


<210>  216
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  216

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Trp Asn Gly Gly Ser Ile Gly Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Gly Asp Ile Leu Thr Gly Phe Tyr Gly Glu Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
                325                 330                 335     


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Leu Gly Lys 
    450             


<210>  217
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  217
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgaaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaagca      120

gggaaagccc ctaacctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagag tacactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacatta tcccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  218
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  218

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Ala Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ile Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  219
<211>  1362
<212>  DNA
<213>  Homo sapiens

<400>  219
gaagtgcagc tggtggagtc tgggggaggg ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaagt gttaggtgga atggtggtat tataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag acctgaggac acggccctct attactgtgc aaaagatata      300

ggcgatgttt tgactggtta ttatggagaa tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctcagc ctccaccaag ggcccatcgg tcttccccct ggcgccctgc      420

tccaggagca cctccgagag cacagccgcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cgaagaccta cacctgcaac gtagatcaca agcccagcaa caccaaggtg      660

gacaagagag ttgagtccaa atatggtccc ccatgcccac cctgcccagc acctgagttc      720

ctggggggac catcagtctt cctgttcccc ccaaaaccca aggacactct catgatctcc      780

cggacccctg aggtcacgtg cgtggtggtg gacgtgagcc aggaagaccc cgaggtccag      840

ttcaactggt acgtggatgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagttcaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aacggcaagg agtacaagtg caaggtctcc aacaaaggcc tcccgtcctc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gagccacagg tgtacaccct gcccccatcc     1080

caggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctacccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaggctcac cgtggacaag     1260

agcaggtggc aggaggggaa tgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacac agaagtccct ctccctgtct ctgggtaaat ga                        1362


<210>  220
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  220

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Val Arg Trp Asn Gly Gly Ile Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Gly Asp Val Leu Thr Gly Tyr Tyr Gly Glu Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
                325                 330                 335     


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Leu Gly Lys 
    450             


<210>  221
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  221
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcgcttgcc gggcaagtca gagcattacc acctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagtag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacattt ccccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  222
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  222

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Gln Ser Ile Thr Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ile Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  223
<211>  1362
<212>  DNA
<213>  Homo sapiens

<400>  223
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaagtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aattatggca tacactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcgatt atattatatg atggaagtaa tcaacactat      180

gcagattccg tgaagggccg attcaccatt tccagagaca attccaaaaa cacgctgtat      240

cttcaaatga acaacctgag agctgaggac acggccgttt attactgtgc gagagatctt      300

gatctttgga gtggttatta tacaaacggg gacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctcagc ctccaccaag ggcccatcgg tcttccccct ggcgccctgc      420

tccaggagca cctccgagag cacagccgcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cgaagaccta cacctgcaac gtagatcaca agcccagcaa caccaaggtg      660

gacaagagag ttgagtccaa atatggtccc ccatgcccac cctgcccagc acctgagttc      720

ctggggggac catcagtctt cctgttcccc ccaaaaccca aggacactct catgatctcc      780

cggacccctg aggtcacgtg cgtggtggtg gacgtgagcc aggaagaccc cgaggtccag      840

ttcaactggt acgtggatgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagttcaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aacggcaagg agtacaagtg caaggtctcc aacaaaggcc tcccgtcctc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gagccacagg tgtacaccct gcccccatcc     1080

caggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctacccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaggctcac cgtggacaag     1260

agcaggtggc aggaggggaa tgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacac agaagtccct ctccctgtct ctgggtaaat ga                        1362


<210>  224
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  224

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Leu Tyr Asp Gly Ser Asn Gln His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Asp Leu Trp Ser Gly Tyr Tyr Thr Asn Gly Asp Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
                325                 330                 335     


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Leu Gly Lys 
    450             


<210>  225
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  225
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccgat caccttcggc      300

caagggacac gactggagat taaaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      645


<210>  226
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  226

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  227
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant Human IL-36R polypeptide (hIL-36R.mmH)

<400>  227

Asp Gly Cys Lys Asp Ile Phe Met Lys Asn Glu Ile Leu Ser Ala Ser 
1               5                   10                  15      


Gln Pro Phe Ala Phe Asn Cys Thr Phe Pro Pro Ile Thr Ser Gly Glu 
            20                  25                  30          


Val Ser Val Thr Trp Tyr Lys Asn Ser Ser Lys Ile Pro Val Ser Lys 
        35                  40                  45              


Ile Ile Gln Ser Arg Ile His Gln Asp Glu Thr Trp Ile Leu Phe Leu 
    50                  55                  60                  


Pro Met Glu Trp Gly Asp Ser Gly Val Tyr Gln Cys Val Ile Lys Gly 
65                  70                  75                  80  


Arg Asp Ser Cys His Arg Ile His Val Asn Leu Thr Val Phe Glu Lys 
                85                  90                  95      


His Trp Cys Asp Thr Ser Ile Gly Gly Leu Pro Asn Leu Ser Asp Glu 
            100                 105                 110         


Tyr Lys Gln Ile Leu His Leu Gly Lys Asp Asp Ser Leu Thr Cys His 
        115                 120                 125             


Leu His Phe Pro Lys Ser Cys Val Leu Gly Pro Ile Lys Trp Tyr Lys 
    130                 135                 140                 


Asp Cys Asn Glu Ile Lys Gly Glu Arg Phe Thr Val Leu Glu Thr Arg 
145                 150                 155                 160 


Leu Leu Val Ser Asn Val Ser Ala Glu Asp Arg Gly Asn Tyr Ala Cys 
                165                 170                 175     


Gln Ala Ile Leu Thr His Ser Gly Lys Gln Tyr Glu Val Leu Asn Gly 
            180                 185                 190         


Ile Thr Val Ser Ile Thr Glu Arg Ala Gly Tyr Gly Gly Ser Val Pro 
        195                 200                 205             


Lys Ile Ile Tyr Pro Lys Asn His Ser Ile Glu Val Gln Leu Gly Thr 
    210                 215                 220                 


Thr Leu Ile Val Asp Cys Asn Val Thr Asp Thr Lys Asp Asn Thr Asn 
225                 230                 235                 240 


Leu Arg Cys Trp Arg Val Asn Asn Thr Leu Val Asp Asp Tyr Tyr Asp 
                245                 250                 255     


Glu Ser Lys Arg Ile Arg Glu Gly Val Glu Thr His Val Ser Phe Arg 
            260                 265                 270         


Glu His Asn Leu Tyr Thr Val Asn Ile Thr Phe Leu Glu Val Lys Met 
        275                 280                 285             


Glu Asp Tyr Gly Leu Pro Phe Met Cys His Ala Gly Val Ser Thr Ala 
    290                 295                 300                 


Tyr Ile Ile Leu Gln Leu Pro Ala Pro Asp Phe Arg Ala Tyr Glu Gln 
305                 310                 315                 320 


Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln Lys Leu Ile Ser 
                325                 330                 335     


Glu Glu Asp Leu His His His His His His 
            340                 345


<210>  228
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  228

Tyr Lys Gln Ile Leu His Leu 
1               5           


<210>  229
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  229

Tyr Lys Gln Ile Leu His Leu Gly Lys Asp 
1               5                   10  


<210>  230
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  230

Gly Val Glu Thr His Val Ser Phe Arg Glu His Asn Tyr Leu 
1               5                   10                  


<210>  231
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  231

Ile Leu His Leu 
1               


<210>  232
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  232

Ile Leu His Leu Gly Lys Asp 
1               5           


<210>  233
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  233

Gly Val Glu Thr His Val Ser Phe 
1               5               


<210>  234
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  234

Thr His Val Ser Phe 
1               5   


<210>  235
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  235

His Val Ser Phe 
1               


<210>  236
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  236

His Val Ser Phe Arg Glu His Asn Leu 
1               5                   


<210>  237
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  237

His Val Ser Phe Arg Glu His Asn Leu Tyr 
1               5                   10  


<210>  238
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  238

Phe Arg Glu His Asn Leu 
1               5    


<210>  239
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide: APE6155 heavy chain (comprising an IgG4 constant 
       domain)

<400>  239

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Arg Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Phe His Pro Thr Gly Asp Val Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Thr Ser Met Ile Ile Gly Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  240
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide: APE6155 light chain (comprising a Kappa constant 
       domain)

<400>  240

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 
            20                  25                  30          


Asn Ala Ile Thr Tyr Phe Tyr Trp Tyr Leu His Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 





   


  

