                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanfod Junior 
       University
       Garcia, Christopher K
       Miao, Yi
       Baker, David
       Dang, Luke
       Park, Keunwan
 
<120>  Frizzled-Specific Wnt Agonists and Antagonists

<130>  STAN-1493WO

<140>  PCT/US2019/041852
<141>  2019-07-15

<150>  US 62/698,576
<151>  2018-07-16

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  192
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  1

Ser Glu Leu Gly Thr Arg Leu Ile Arg Ala Ala Leu Asp Gly Asn Lys 
1               5                   10                  15      


Asp Arg Val Lys Asp Leu Ile Glu Asn Gly Ala Asp Val Asn Ala Ser 
            20                  25                  30          


Leu Met Ser Gly Ala Thr Pro Leu His Ala Ala Ala Met Asn Gly His 
        35                  40                  45              


Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val Asn Ala 
    50                  55                  60                  


Gln Ser Val Ala Gly Ser Thr Pro Leu Asp Ala Ala Ala Phe Ser Gly 
65                  70                  75                  80  


His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val Asn 
                85                  90                  95      


Ala Val Asn Ala Ala Gly Leu Thr Pro Leu His Ala Ala Ala Asp Asn 
            100                 105                 110         


Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val 
        115                 120                 125             


Asn Ala Lys Ala Asp His Gly Met Thr Pro Leu His Phe Ala Ala Gln 
    130                 135                 140                 


Arg Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp 
145                 150                 155                 160 


Leu Asn Thr Ser Ala Lys Asp Gly Ala Thr Pro Leu Asp Met Ala Arg 
                165                 170                 175     


Glu Ser Gly Asn Glu Glu Val Val Lys Leu Leu Glu Lys Gln Leu Glu 
            180                 185                 190         


<210>  2
<211>  192
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  2

Ser Glu Leu Gly Lys Arg Leu Ile Met Ala Ala Leu Asp Gly Asn Lys 
1               5                   10                  15      


Asp Arg Val Lys Asp Leu Ile Glu Asn Gly Ala Asp Val Asn Ala Ser 
            20                  25                  30          


Leu Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala Met Asn Gly His 
        35                  40                  45              


Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val Asn Ala 
    50                  55                  60                  


Gln Ser Ala Ala Gly Ser Thr Pro Leu Ala Ala Ala Ala Ile Asn Gly 
65                  70                  75                  80  


His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val Asn 
                85                  90                  95      


Ala Val Thr Ala Ala Gly Met Thr Pro Leu His Ala Ala Ala Ala Asn 
            100                 105                 110         


Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val 
        115                 120                 125             


Asn Ala Lys Ala Asp Arg Gly Met Thr Pro Leu His Phe Ala Ala Trp 
    130                 135                 140                 


Arg Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp 
145                 150                 155                 160 


Leu Asn Thr Ser Ala Lys Asp Gly Ala Thr Pro Leu Asp Met Ala Arg 
                165                 170                 175     


Glu Ser Gly Asn Glu Glu Val Val Lys Leu Leu Glu Lys Gln Leu Glu 
            180                 185                 190         


<210>  3
<211>  192
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  3

Ser Glu Leu Gly Thr Arg Leu Ile Arg Ala Ala Leu Asp Gly Asn Lys 
1               5                   10                  15      


Asp Arg Val Lys Asp Leu Ile Glu Asn Gly Ala Asp Val Asn Ala Ser 
            20                  25                  30          


Leu Met Ser Gly Ala Thr Pro Leu His Ala Ala Ala Met Asn Gly His 
        35                  40                  45              


Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val Asn Ala 
    50                  55                  60                  


Gln Ser Val Ala Gly Ser Thr Pro Leu Asp Ala Ala Ala Phe Ser Gly 
65                  70                  75                  80  


His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val Asn 
                85                  90                  95      


Ala Val Asn Ala Ala Gly Leu Thr Pro Leu His Asp Ala Ala Asp Asp 
            100                 105                 110         


Gly His Asn Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val 
        115                 120                 125             


Asn Ala Lys Ala Asp His Gly Met Thr Pro Leu His Phe Ala Ala Gln 
    130                 135                 140                 


Arg Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp 
145                 150                 155                 160 


Leu Asn Thr Ser Ala Lys Asp Gly Ala Thr Pro Leu Asp Met Ala Arg 
                165                 170                 175     


Glu Ser Gly Asn Glu Glu Val Val Lys Leu Leu Glu Lys Gln Leu Glu 
            180                 185                 190         


<210>  4
<211>  192
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4

Ser Glu Leu Gly Lys Arg Leu Ile Arg Ala Ala Leu Asp Gly Asn Lys 
1               5                   10                  15      


Asp Arg Val Lys Asp Leu Ile Glu Asn Gly Ala Asp Val Asn Ala Ser 
            20                  25                  30          


Leu Met Ser Gly Thr Thr Pro Leu Tyr Ala Ala Ala Met Asn Gly His 
        35                  40                  45              


Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val Asn Ala 
    50                  55                  60                  


Gln Ser Val Ala Gly Ser Thr Pro Leu Val Ala Ala Ala Asn Phe Gly 
65                  70                  75                  80  


His Asn Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val Asn 
                85                  90                  95      


Ala Val Thr Ala Phe Gly Val Thr Pro Leu His Ala Ala Ala Ala Asp 
            100                 105                 110         


Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val 
        115                 120                 125             


Asn Ala Lys Ala Gly Arg Gly Met Thr Pro Leu His Ile Ala Ala Phe 
    130                 135                 140                 


Arg Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp 
145                 150                 155                 160 


Leu Asn Thr Ser Ala Lys Asp Gly Ala Thr Pro Leu Asp Met Ala Arg 
                165                 170                 175     


Glu Ser Gly Asn Glu Glu Val Val Lys Leu Leu Glu Lys Gln Leu Glu 
            180                 185                 190         


<210>  5
<211>  292
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5

Ser Glu Leu Gly Thr Arg Leu Ile Arg Ala Ala Leu Asp Gly Asn Lys 
1               5                   10                  15      


Asp Arg Val Lys Asp Leu Ile Glu Asn Gly Ala Asp Val Asn Ala Ser 
            20                  25                  30          


Leu Met Ser Gly Ala Thr Pro Leu His Ala Ala Ala Met Asn Gly His 
        35                  40                  45              


Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val Asn Ala 
    50                  55                  60                  


Gln Ser Val Ala Gly Ser Thr Pro Leu Asp Ala Ala Ala Phe Ser Gly 
65                  70                  75                  80  


His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val Asn 
                85                  90                  95      


Ala Val Asn Ala Ala Gly Leu Thr Pro Leu His Ala Ala Ala Asp Asn 
            100                 105                 110         


Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val 
        115                 120                 125             


Asn Ala Lys Ala Asp His Gly Met Thr Pro Leu His Phe Ala Ala Gln 
    130                 135                 140                 


Arg Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp 
145                 150                 155                 160 


Leu Asn Thr Ser Ala Lys Asp Gly Ala Thr Pro Leu Asp Met Ala Arg 
                165                 170                 175     


Glu Ser Gly Asn Glu Glu Val Val Lys Leu Leu Glu Lys Gln Leu Glu 
            180                 185                 190         


Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Lys Met Tyr His Thr Lys 
        195                 200                 205             


Gly Gln Glu Gly Ser Val Cys Leu Arg Ser Ser Asp Cys Ala Ser Gly 
    210                 215                 220                 


Leu Cys Cys Ala Arg His Phe Trp Ser Lys Ile Cys Lys Pro Val Leu 
225                 230                 235                 240 


Lys Glu Gly Gln Val Cys Thr Lys His Arg Arg Lys Gly Ser His Gly 
                245                 250                 255     


Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly Glu Gly Leu Ser Cys Arg 
            260                 265                 270         


Ile Gln Lys Asp His His Gln Ala Ser Asn Ser Ser Arg Leu His Thr 
        275                 280                 285             


Cys Gln Arg His 
    290         


<210>  6
<211>  292
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6

Ser Glu Leu Gly Lys Arg Leu Ile Met Ala Ala Leu Asp Gly Asn Lys 
1               5                   10                  15      


Asp Arg Val Lys Asp Leu Ile Glu Asn Gly Ala Asp Val Asn Ala Ser 
            20                  25                  30          


Leu Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala Met Asn Gly His 
        35                  40                  45              


Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val Asn Ala 
    50                  55                  60                  


Gln Ser Ala Ala Gly Ser Thr Pro Leu Ala Ala Ala Ala Ile Asn Gly 
65                  70                  75                  80  


His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val Asn 
                85                  90                  95      


Ala Val Thr Ala Ala Gly Met Thr Pro Leu His Ala Ala Ala Ala Asn 
            100                 105                 110         


Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val 
        115                 120                 125             


Asn Ala Lys Ala Asp Arg Gly Met Thr Pro Leu His Phe Ala Ala Trp 
    130                 135                 140                 


Arg Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp 
145                 150                 155                 160 


Leu Asn Thr Ser Ala Lys Asp Gly Ala Thr Pro Leu Asp Met Ala Arg 
                165                 170                 175     


Glu Ser Gly Asn Glu Glu Val Val Lys Leu Leu Glu Lys Gln Leu Glu 
            180                 185                 190         


Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Lys Met Tyr His Thr Lys 
        195                 200                 205             


Gly Gln Glu Gly Ser Val Cys Leu Arg Ser Ser Asp Cys Ala Ser Gly 
    210                 215                 220                 


Leu Cys Cys Ala Arg His Phe Trp Ser Lys Ile Cys Lys Pro Val Leu 
225                 230                 235                 240 


Lys Glu Gly Gln Val Cys Thr Lys His Arg Arg Lys Gly Ser His Gly 
                245                 250                 255     


Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly Glu Gly Leu Ser Cys Arg 
            260                 265                 270         


Ile Gln Lys Asp His His Gln Ala Ser Asn Ser Ser Arg Leu His Thr 
        275                 280                 285             


Cys Gln Arg His 
    290         


<210>  7
<211>  292
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7

Ser Glu Leu Gly Thr Arg Leu Ile Arg Ala Ala Leu Asp Gly Asn Lys 
1               5                   10                  15      


Asp Arg Val Lys Asp Leu Ile Glu Asn Gly Ala Asp Val Asn Ala Ser 
            20                  25                  30          


Leu Met Ser Gly Ala Thr Pro Leu His Ala Ala Ala Met Asn Gly His 
        35                  40                  45              


Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val Asn Ala 
    50                  55                  60                  


Gln Ser Val Ala Gly Ser Thr Pro Leu Asp Ala Ala Ala Phe Ser Gly 
65                  70                  75                  80  


His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val Asn 
                85                  90                  95      


Ala Val Asn Ala Ala Gly Leu Thr Pro Leu His Asp Ala Ala Asp Asp 
            100                 105                 110         


Gly His Asn Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp Val 
        115                 120                 125             


Asn Ala Lys Ala Asp His Gly Met Thr Pro Leu His Phe Ala Ala Gln 
    130                 135                 140                 


Arg Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala Asp 
145                 150                 155                 160 


Leu Asn Thr Ser Ala Lys Asp Gly Ala Thr Pro Leu Asp Met Ala Arg 
                165                 170                 175     


Glu Ser Gly Asn Glu Glu Val Val Lys Leu Leu Glu Lys Gln Leu Glu 
            180                 185                 190         


Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Lys Met Tyr His Thr Lys 
        195                 200                 205             


Gly Gln Glu Gly Ser Val Cys Leu Arg Ser Ser Asp Cys Ala Ser Gly 
    210                 215                 220                 


Leu Cys Cys Ala Arg His Phe Trp Ser Lys Ile Cys Lys Pro Val Leu 
225                 230                 235                 240 


Lys Glu Gly Gln Val Cys Thr Lys His Arg Arg Lys Gly Ser His Gly 
                245                 250                 255     


Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly Glu Gly Leu Ser Cys Arg 
            260                 265                 270         


Ile Gln Lys Asp His His Gln Ala Ser Asn Ser Ser Arg Leu His Thr 
        275                 280                 285             


Cys Gln Arg His 
    290         


<210>  8
<211>  292
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  8

Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser 
1               5                   10                  15      


Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys 
            20                  25                  30          


Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg 
        35                  40                  45              


Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly 
    50                  55                  60                  


Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn 
65                  70                  75                  80  


Ser Ser Arg Leu His Thr Cys Gln Arg His Gly Ser Gly Ser Gly Gly 
                85                  90                  95      


Ser Gly Ser Gly Ser Glu Leu Gly Lys Arg Leu Ile Arg Ala Ala Leu 
            100                 105                 110         


Asp Gly Asn Lys Asp Arg Val Lys Asp Leu Ile Glu Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Ser Leu Met Ser Gly Thr Thr Pro Leu Tyr Ala Ala Ala 
    130                 135                 140                 


Met Asn Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys Gly Ala 
145                 150                 155                 160 


Asp Val Asn Ala Gln Ser Val Ala Gly Ser Thr Pro Leu Val Ala Ala 
                165                 170                 175     


Ala Asn Phe Gly His Asn Glu Val Val Lys Leu Leu Ile Ser Lys Gly 
            180                 185                 190         


Ala Asp Val Asn Ala Val Thr Ala Phe Gly Val Thr Pro Leu His Ala 
        195                 200                 205             


Ala Ala Ala Asp Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys 
    210                 215                 220                 


Gly Ala Asp Val Asn Ala Lys Ala Gly Arg Gly Met Thr Pro Leu His 
225                 230                 235                 240 


Ile Ala Ala Phe Arg Gly His Lys Glu Val Val Lys Leu Leu Ile Ser 
                245                 250                 255     


Lys Gly Ala Asp Leu Asn Thr Ser Ala Lys Asp Gly Ala Thr Pro Leu 
            260                 265                 270         


Asp Met Ala Arg Glu Ser Gly Asn Glu Glu Val Val Lys Leu Leu Glu 
        275                 280                 285             


Lys Gln Leu Glu 
    290         


<210>  9
<211>  890
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9
ggatcctctg aactgggtac gcgtctgatc agggcagcat tagacggtaa caaagaccgt       60

gttaaagacc tcattgaaaa tggtgctgac gttaacgcgt cccttatgtc tggggcgact      120

ccgttacacg ccgccgccat gaacggccac aaagaggttg tgaagttact gatctccaag      180

ggcgcagatg tgaatgctca gtccgttgcg ggttctacac ctctggatgc ggcggcgttt      240

agtggacata aagaagtggt aaaactgctg ataagtaaag gagcagacgt caatgctgtt      300

aatgcggctg gattgacccc cctacatgct gctgctgata atgggcacaa ggaagtagtg      360

aagttgctta tttctaaggg ggccgacgta aatgcgaaag ctgaccatgg catgactcca      420

ctccatttcg cagcacagcg cggtcataag gaagtcgtta aactattaat cagcaaaggt      480

gcggatttga acacctctgc caaagacggt gcaaccccgc ttgacatggc gcgtgaatct      540

ggcaatgagg aggttgtcaa gctcttggaa aagcaactcg agggaagcgg ttccggaggt      600

tctggctccg gaaaaatgta tcacactaag ggacaggaag gcagcgtgtg cctgaggtcc      660

tctgactgtg catctggcct gtgctgcgcc agacactttt ggtccaaaat ctgcaagccg      720

gttctgaaag agggccaggt gtgcacaaag catcgacgaa agggcagcca tggactcgag      780

atctttcaga ggtgctactg cggggagggt ctgtcttgca gaatccagaa agatcatcat      840

caggcctcca actcctcccg cctgcacacc tgccagcgac atgcggccgc                 890


<210>  10
<211>  890
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10
ggatccagcg aactcggcac ccgacttatc agagctgccc ttgatggaaa taaggaccgg       60

gtcaaagacc tgatagagaa tggggcggac gttaatgcaa gtcttatgtc cggtgctacc      120

ccgttgcatg ccgctgcaat gaatggccac aaggaggttg taaaattgct cataagtaaa      180

ggcgcagacg taaacgcaca atccgtggcg ggcagtaccc ccttggatgc cgctgcgttc      240

tcaggccata aagaggtcgt aaaactgctg atctccaaag gagcggacgt caatgcagta      300

aatgctgcag gacttacccc cttgcacgcc gctgccgaca atggacacaa ggaggttgta      360

aaacttctca tatctaaagg cgcggacgtc aacgctaaag cggaccacgg aatgacgccg      420

ctccactttg cggcacagag gggccataaa gaggtagtga aacttctgat ctcaaaagga      480

gccgacttga atacgagcgc taaggatggt gcaacgccat tggatatggc cagggagtcc      540

ggaaatgaag aggtggtgaa gctgcttgag aagcaactcg aaggtagcgg gagcggcggg      600

agtggctctg gcaagatgta ccataccaag ggccaagaag ggagtgtgtg cctgcggtca      660

agcgactgcg catcaggctt gtgctgtgct aggcatttct ggtccaagat ttgtaagcca      720

gtattgaagg aaggccaggt gtgtactaaa cataggcgca agggaagtca tggtctcgag      780

atattccaac gctgttactg tggcgaggga ttgtcttgcc gcatacaaaa agaccaccac      840

caggcgtcta actctagtag gcttcacaca tgccaacggc acgcggccgc                 890


<210>  11
<211>  993
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  11
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  12
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  12

Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser 
1               5                   10                  15      


Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys 
            20                  25                  30          


Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg 
        35                  40                  45              


Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly 
    50                  55                  60                  


Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn 
65                  70                  75                  80  


Ser Ser Arg Leu His Thr Cys Gln Arg His 
                85                  90  


<210>  13
<211>  88
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  13

Lys Met Ser His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser 
1               5                   10                  15      


Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys 
            20                  25                  30          


Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg 
        35                  40                  45              


Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala 
    50                  55                  60                  


Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys 
65                  70                  75                  80  


Ala Arg Leu His Val Cys Gln Lys 
                85              


<210>  14
<211>  561
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  14

Met Ala Arg Pro Leu Cys Thr Leu Leu Leu Leu Met Ala Thr Leu Ala 
1               5                   10                  15      


Gly Ala Leu Ala Gly Ser Ser Glu Leu Gly Thr Arg Leu Ile Arg Ala 
            20                  25                  30          


Ala Leu Asp Gly Asn Lys Asp Arg Val Lys Asp Leu Ile Glu Asn Gly 
        35                  40                  45              


Ala Asp Val Asn Ala Ser Leu Met Ser Gly Ala Thr Pro Leu His Ala 
    50                  55                  60                  


Ala Ala Met Asn Gly His Lys Glu Val Val Lys Leu Leu Ile Ser Lys 
65                  70                  75                  80  


Gly Ala Asp Val Asn Ala Gln Ser Val Ala Gly Ser Thr Pro Leu Asp 
                85                  90                  95      


Ala Ala Ala Phe Ser Gly His Lys Glu Val Val Lys Leu Leu Ile Ser 
            100                 105                 110         


Lys Gly Ala Asp Val Asn Ala Val Asn Ala Ala Gly Leu Thr Pro Leu 
        115                 120                 125             


His Ala Ala Ala Asp Asn Gly His Lys Glu Val Val Lys Leu Leu Ile 
    130                 135                 140                 


Ser Lys Gly Ala Asp Val Asn Ala Lys Ala Asp His Gly Met Thr Pro 
145                 150                 155                 160 


Leu His Phe Ala Ala Gln Arg Gly His Lys Glu Val Val Lys Leu Leu 
                165                 170                 175     


Ile Ser Lys Gly Ala Asp Leu Asn Thr Ser Ala Lys Asp Gly Ala Thr 
            180                 185                 190         


Pro Leu Asp Met Ala Arg Glu Ser Gly Asn Glu Glu Val Val Lys Leu 
        195                 200                 205             


Leu Glu Lys Gln Leu Glu Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
    210                 215                 220                 


Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser 
225                 230                 235                 240 


Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys 
                245                 250                 255     


Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg 
            260                 265                 270         


Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly 
        275                 280                 285             


Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn 
    290                 295                 300                 


Ser Ser Arg Leu His Thr Cys Gln Arg His Ala Ala Ala Glu Asn Leu 
305                 310                 315                 320 


Tyr Phe Gln Gly Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
                325                 330                 335     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        355                 360                 365             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    370                 375                 380                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
385                 390                 395                 400 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                405                 410                 415     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            420                 425                 430         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        435                 440                 445             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
465                 470                 475                 480 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                485                 490                 495     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            500                 505                 510         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        515                 520                 525             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    530                 535                 540                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Ala 
545                 550                 555                 560 


Ala 
    


<210>  15
<211>  1686
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  15
atggcccggc ctctgtgtac cctgctactc ctgatggcta ccctggctgg ggctctggcc       60

ggatccagcg aactcggcac ccgacttatc agagctgccc ttgatggaaa taaggaccgg      120

gtcaaagacc tgatagagaa tggggcggac gttaatgcaa gtcttatgtc cggtgctacc      180

ccgttgcatg ccgctgcaat gaatggccac aaggaggttg taaaattgct cataagtaaa      240

ggcgcagacg taaacgcaca atccgtggcg ggcagtaccc ccttggatgc cgctgcgttc      300

tcaggccata aagaggtcgt aaaactgctg atctccaaag gagcggacgt caatgcagta      360

aatgctgcag gacttacccc cttgcacgcc gctgccgaca atggacacaa ggaggttgta      420

aaacttctca tatctaaagg cgcggacgtc aacgctaaag cggaccacgg aatgacgccg      480

ctccactttg cggcacagag gggccataaa gaggtagtga aacttctgat ctcaaaagga      540

gccgacttga atacgagcgc taaggatggt gcaacgccat tggatatggc cagggagtcc      600

ggaaatgaag aggtggtgaa gctgcttgag aagcaactcg aaggtagcgg gagcggcggg      660

agtggctctg gcaagatgta ccataccaag ggccaagaag ggagtgtgtg cctgcggtca      720

agcgactgcg catcaggctt gtgctgtgct aggcatttct ggtccaagat ttgtaagcca      780

gtattgaagg aaggccaggt gtgtactaaa cataggcgca agggaagtca tggtctcgag      840

atattccaac gctgttactg tggcgaggga ttgtcttgcc gcatacaaaa agaccaccac      900

caggcgtcta actctagtag gcttcacaca tgccaacggc acgcggccgc agagaacctg      960

tacttccagg gatcttccga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc     1020

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     1080

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1140

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1200

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1260

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1320

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1380

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     1440

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1500

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1560

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1620

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaaggggcc     1680

gcatag                                                                1686


<210>  16
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  16

Met Ala Arg Pro Leu Cys Thr Leu Leu Leu Leu Met Ala Thr Leu Ala 
1               5                   10                  15      


Gly Ala Leu Ala 
            20  


<210>  17
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  17

Glu Asn Leu Tyr Phe Gln Gly Ser 
1               5               


<210>  18
<211>  236
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  18

Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Ala Ala 
225                 230                 235     


