                         SEQUENCE LISTING

<110>  Development Center for Biotechnology
       DCB-USA LLC
 
<120>  ANTI-HUMAN PD-L1 ANTIBODIES AND THEIR USES

<130>  DCB024-775PCT

<150>  US 62/698096
<151>  2018-07-14

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  1

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Ser Phe 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Asp Lys Ala Ser Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Asp Gly Asp Tyr Gly Arg Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  2
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  2

Gly Tyr Ile Phe Ile Ser Phe Trp Ile His 
1               5                   10  


<210>  3
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  3

Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  4
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  4

Ala Arg Leu Asp Gly Asp Tyr Gly Arg Ala Tyr 
1               5                   10      


<210>  5
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  5

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Ser Phe 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Asp Lys Ala Ser Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Asp Gly Asp Tyr Gly Arg Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  6
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  6

Gly Tyr Ile Phe Ile Ser Phe Trp Ile His 
1               5                   10  


<210>  7
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  7

Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Glu Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  8
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  8

Ala Arg Leu Asp Gly Asp Tyr Gly Arg Ala Tyr 
1               5                   10      


<210>  9
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Thr Ser 
            20                  25                  30          


Trp Ile Asn Trp Leu Lys Gln Arg Pro Gly Glu Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Ile Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala His 
65                  70                  75                  80  


Ile Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Asn His Tyr Tyr Phe Asp Phe Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  10
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  10

Gly Tyr Ala Phe Ser Thr Ser Trp Ile Asn 
1               5                   10  


<210>  11
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  11

Arg Ile Tyr Pro Gly Asp Gly Asp Ile Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  12
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  12

Ser Asn His Tyr Tyr Phe Asp Phe 
1               5               


<210>  13
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Thr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Glu Asp Thr Asn Tyr Asn Gly Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ile Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Asp Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  14
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  14

Gly Tyr Ala Phe Ser Thr Ser Trp Met Asn 
1               5                   10  


<210>  15
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  15

Arg Ile Tyr Pro Gly Asp Glu Asp Thr Asn Tyr Asn Gly Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  16

Ser Asp Asn Tyr Tyr Phe Asp Tyr 
1               5               


<210>  17
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ala Gly Ser Tyr Thr Ile Tyr Tyr Ala Asp Ile Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Trp Tyr Phe Ala Val Trp Gly Ala Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  18
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  18

Gly Phe Thr Phe Ser Asp Ser Gly Met His 
1               5                   10  


<210>  19
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  19

Tyr Ile Ser Ala Gly Ser Tyr Thr Ile Tyr Tyr Ala Asp Ile Val Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  20

Gly Asp Trp Tyr Phe Ala Val 
1               5           


<210>  21
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  21

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  22
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  22

Arg Ala Ser Glu Ser Val Asp Ser Phe Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  23
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  23

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  24

Gln Gln Asn Asn Glu Asp Pro Leu Thr 
1               5                   


<210>  25
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  25

Asn Ile Ala Leu Thr Gln Ser Pro Thr Ser Leu Ala Val Ser Gln Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Asn 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Asp Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  26
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  26

Arg Ala Ser Glu Ser Val Asp Ser Asn Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  27
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  27

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  28

Gln Gln Asn Asn Asp Asp Pro Trp Thr 
1               5                   


<210>  29
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  29

Asp Val Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Arg Ala Ser Glu Asp Ile Arg Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Asp Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Val His Thr Leu Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  30
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  30

Arg Ala Ser Glu Asp Ile Arg Thr Tyr Leu Asn 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  31

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  32
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  32

Gln Gln Val His Thr Leu Pro Pro Trp Thr 
1               5                   10  


<210>  33
<211>  89
<212>  PRT
<213>  Mus musculus

<400>  33

Ile Thr Cys Arg Ala Ser Asp Asp Ile Arg Thr Tyr Leu Asn Trp Tyr 
1               5                   10                  15      


Gln Gln Lys Pro Asp Gly Ser Val Lys Leu Leu Ile Tyr Tyr Thr Ser 
            20                  25                  30          


Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        35                  40                  45              


Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Val Gln Glu Asp Phe Ala 
    50                  55                  60                  


Thr Tyr Phe Cys Gln Gln Val His Thr Leu Pro Pro Trp Thr Phe Gly 
65                  70                  75                  80  


Gly Gly Thr Lys Leu Glu Ile Lys Arg 
                85                  


<210>  34
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  34

Arg Ala Ser Asp Asp Ile Arg Thr Tyr Leu Asn 
1               5                   10      


<210>  35
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  35

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  36
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  36

Gln Gln Val His Thr Leu Pro Pro Trp Thr 
1               5                   10  


<210>  37
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  37

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ile 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Pro Glu Asp Leu Gly Val Tyr Tyr Cys Ser Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  38
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  38

Arg Ser Ser Gln Ser Leu Val His Ile Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  39
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  39

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  40

Ser Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  41
<211>  354
<212>  DNA
<213>  Mus musculus

<400>  41
caggtccaac tgcagcagcc ggggactgag ctggtgaagc ctggggcttc agtgaaactg       60

tcctgtaagg cttctggcta catcttcatc agcttctgga tacactgggt gaagcagagg      120

cctggacaag gccttaaatg gattggtaat attgaccctt ctgatagtga aactcactac      180

aatcaaaagt tcaaggacaa ggccacattg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aagattggat      300

ggtgactacg ggagggctta ctggggccaa gggactctgg tcactgtctc tgca            354


<210>  42
<211>  354
<212>  DNA
<213>  Mus musculus

<400>  42
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaaactg       60

tcctgcaagg cttctggcta catcttcatc agcttctgga tacactgggt gaagcagagg      120

cctggacaag gccttgaatg gattggtaat attgaccctt ctgatagtga aactcactac      180

aatgaaaaat tcagggacaa ggcctcattg actgtagaca agtcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct atttctgtgc aaggttggat      300

ggtgactacg ggagggctta ctggggccaa gggactctgg tcactgtctc tgca            354


<210>  43
<211>  351
<212>  DNA
<213>  Mus musculus

<400>  43
caggttcagt tgcagcagtc tggacctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaagg cctctggcta tgcattcagt acctcctgga taaactggct gaagcagagg      120

cctggagagg gtcttgagtg gcttggacgg atttatcctg gagatggaga tataaactac      180

aatgggaagt tcaaggacaa ggccacactg actgcagaca aatcctccag tacagcccac      240

atacaactca acagcctgac atctgaggac tctgcggtct acttctgtgc aagatcgaat      300

cattactact ttgacttctg gggccaaggc accactctca cagtctcctc a               351


<210>  44
<211>  351
<212>  DNA
<213>  Mus musculus

<400>  44
caggttcagc tgcagcagtc tggacctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaagg cttctggcta tgcattcagt acctcctgga tgaactgggt aaagcagagg      120

cctggaaagg gtcttgagta gattggacgg atttatcctg gagatgaaga tactaactac      180

aatgggaact tcaagggcaa ggccacactg actgcagaca aatcttccag tacagcctat      240

atgcaactca tcagcctgac atctgaggac tctgcggtct acttctgtgc aagatcggat      300

aattactact ttgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  45
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  45
gaggtgcagc tggtggagtc tgggggaggc tttgtgaagc ctggagggtc ccggaaactc       60

tcctgtgcag cctctggatt cactttcagt gactctggaa tgcactgggt ccgtcaggct      120

ccagagaagg ggctggagtg ggttgcatac attagtgctg gcagttatac catctactat      180

gcagacatag tgaagggccg attcaccatc tctagagaca gtgccaagaa caccctgttc      240

ctgcaaatga ccagtctaag gtctgaggac acagccattt attattgtgc aagaggggac      300

tggtacttcg ctgtctgggg cgcagggacc acggtcaccg tctcctca                   348


<210>  46
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  46
aacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctaggaca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agttttggca atagttttat gcactggtac      120

cagcagaaac caggacagcc gcccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattgat      240

cctgtggagg ctgatgatac tgcaacctat tactgtcagc aaaataatga ggatccgttg      300

acgttcggtg gaggcaccaa actggaaatc aaacgg                                336


<210>  47
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  47
aacattgcgc tgacccaatc tccaacttct ttggctgtgt ctcaagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agtaatggca atagttttat gcactggtac      120

cagcagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctaggacag atttcaccct caccattgat      240

cctgtggagg ctgatgatgc tgcaacctat tactgtcagc aaaataatga cgatccgtgg      300

acgttcggtg gaggcacaaa gctggaaatc aaacgg                                336


<210>  48
<211>  327
<212>  DNA
<213>  Mus musculus

<400>  48
gatgtccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcaattgca gggcaagtga agacattaga acttatttaa actggtatca gcagaaacca      120

gatggaacta ttaaactcct gatctactac acatccagat tacattcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggaccaa      240

gaagatattg ccacttactt ttgtcaacag gttcatacac ttcctccgtg gacgttcggt      300

ggaggcacca aactggaaat caaacgg                                          327


<210>  49
<211>  327
<212>  DNA
<213>  Mus musculus

<400>  49
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcacttgca gggcaagtga tgacattagg acttatttaa actggtatca gcagaaacca      120

gatggatctg ttaaactcct gatctactac acatcaagat tacactcggg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggttcaa      240

gaagattttg ccacttattt ttgccaacag gttcatacgc ttcctccgtg gacgttcggt      300

ggaggcacca agctggaaat caaacgt                                          327


<210>  50
<211>  339
<212>  DNA
<213>  Mus musculus

<400>  50
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta catattaatg gaaacaccta tttagaatgg      120

tacctgcaga aacccggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc ctgacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg agcctgagga tctgggagtt tattactgct ctcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caaggtggaa atcaaacgg                             339


<210>  51
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu His Pro Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu 
    50                  55                  60                  


Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val 
65                  70                  75                  80  


Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu 
                85                  90                  95      


Ser Leu Gly Asn Ala Ala Leu Gln His Pro Asp Leu Ile Thr Asp Val 
            100                 105                 110         


Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly 
        115                 120                 125             


Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Pro Tyr Asn Lys 
    130                 135                 140                 


Ile Asn Gln Arg Ile Leu Val Val Asp Pro Val Thr Ser Glu His Pro 
145                 150                 155                 160 


Asp Leu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys Ala Glu 
                165                 170                 175     


Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys Thr Thr 
            180                 185                 190         


Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr Ser Thr 
        195                 200                 205             


Leu Arg Ile Asn His Pro Asp Leu Thr Thr Thr Asn Glu Ile Phe Tyr 
    210                 215                 220                 


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
225                 230                 235                 240 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
                245                 250                 255     


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys His Pro Asp Leu Leu Gly 
            260                 265                 270         


Val Ala Leu Thr Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp 
        275                 280                 285             


Val Lys Lys Cys Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp 
    290                 295                 300                 


Thr His Leu Glu Glu Thr 
305                 310 


