                         SEQUENCE LISTING

<110>  PIERRE FABRE MEDICAMENT
       FERRE, Pierre
       CRUZALEGUI, Francisco
       LOUKILI, Noureddine
 
<120>  RECEPTOR FOR VISTA

<130>  B3764799PCTD38601

<150>  PCT IB2018/000983
<151>  2018-07-20

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
            180                 185                 190         


Ala Ala Ala Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu 
        195                 200                 205             


Pro Leu Ile Leu Leu Leu Val Tyr Lys Gln Arg Gln Ala Ala Ser Asn 
    210                 215                 220                 


Arg Arg Ala Gln Glu Leu Val Arg Met Asp Ser Asn Ile Gln Gly Ile 
225                 230                 235                 240 


Glu Asn Pro Gly Phe Glu Ala Ser Pro Pro Ala Gln Gly Ile Pro Glu 
                245                 250                 255     


Ala Lys Val Arg His Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser 
            260                 265                 270         


Glu Ser Gly Arg His Leu Leu Ser Glu Pro Ser Thr Pro Leu Ser Pro 
        275                 280                 285             


Pro Gly Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp 
    290                 295                 300                 


Ser Pro Asn Phe Glu Val Ile 
305                 310     


<210>  2
<211>  936
<212>  DNA
<213>  

<400>  2
atgggcgtcc ccacggccct ggaggccggc agctggcgct ggggatccct gctcttcgct       60

ctcttcctgg ctgcgtccct aggtccggtg gcagccttca aggtcgccac gccgtattcc      120

ctgtatgtct gtcccgaggg gcagaacgtc accctcacct gcaggctctt gggccctgtg      180

gacaaagggc acgatgtgac cttctacaag acgtggtacc gcagctcgag gggcgaggtg      240

cagacctgct cagagcgccg gcccatccgc aacctcacgt tccaggacct tcacctgcac      300

catggaggcc accaggctgc caacaccagc cacgacctgg ctcagcgcca cgggctggag      360

tcggcctccg accaccatgg caacttctcc atcaccatgc gcaacctgac cctgctggat      420

agcggcctct actgctgcct ggtggtggag atcaggcacc accactcgga gcacagggtc      480

catggtgcca tggagctgca ggtgcagaca ggcaaagatg caccatccaa ctgtgtggtg      540

tacccatcct cctcccagga tagtgaaaac atcacggctg cagccctggc tacgggtgcc      600

tgcatcgtag gaatcctctg cctccccctc atcctgctcc tggtctacaa gcaaaggcag      660

gcagcctcca accgccgtgc ccaggagctg gtgcggatgg acagcaacat tcaagggatt      720

gaaaaccccg gctttgaagc ctcaccacct gcccagggga tacccgaggc caaagtcagg      780

caccccctgt cctatgtggc ccagcggcag ccttctgagt ctgggcggca tctgctttcg      840

gagcccagca cccccctgtc tcctccaggc cccggagacg tcttcttccc atccctggac      900

cctgtccctg actctccaaa ctttgaggtc atctag                                936


<210>  3
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn 
1               5                   10                  15      


Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu 
            20                  25                  30          


Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr 
        35                  40                  45              


Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg 
    50                  55                  60                  


Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser 
65                  70                  75                  80  


Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly 
                85                  90                  95      


Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu 
            100                 105                 110         


Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala 
        115                 120                 125             


Thr Glu Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr 
    130                 135                 140                 


Arg Leu Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu 
145                 150                 155                 160 


Ala Gln Thr Thr Pro Pro Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro 
                165                 170                 175     


Thr Gly Leu Glu Ala Gln Thr Thr Ala Pro Ala Ala Met Glu Ala Gln 
            180                 185                 190         


Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Pro Pro Ala Ala 
        195                 200                 205             


Met Glu Ala Gln Thr Thr Gln Thr Thr Ala Met Glu Ala Gln Thr Thr 
    210                 215                 220                 


Ala Pro Glu Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu 
225                 230                 235                 240 


Ala Gln Thr Thr Pro Leu Ala Ala Met Glu Ala Leu Ser Thr Glu Pro 
                245                 250                 255     


Ser Ala Thr Glu Ala Leu Ser Met Glu Pro Thr Thr Lys Arg Gly Leu 
            260                 265                 270         


Phe Ile Pro Phe Ser Val Ser Ser Val Thr His Lys Gly Ile Pro Met 
        275                 280                 285             


Ala Ala Ser Asn Leu Ser Val Asn Tyr Pro Val Gly Ala Pro Asp His 
    290                 295                 300                 


Ile Ser Val Lys Gln Cys Leu Leu Ala Ile Leu Ile Leu Ala Leu Val 
305                 310                 315                 320 


Ala Thr Ile Phe Phe Val Cys Thr Val Val Leu Ala Val Arg Leu Ser 
                325                 330                 335     


Arg Lys Gly His Met Tyr Pro Val Arg Asn Tyr Ser Pro Thr Glu Met 
            340                 345                 350         


Val Cys Ile Ser Ser Leu Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala 
        355                 360                 365             


Thr Ala Asn Gly Gly Leu Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro 
    370                 375                 380                 


Glu Pro Arg Glu Asp Arg Glu Gly Asp Asp Leu Thr Leu His Ser Phe 
385                 390                 395                 400 


Leu Pro 
        


<210>  4
<211>  2226
<212>  DNA
<213>  Homo sapiens

<400>  4
atggggtgtg ggctgtcaca tggccctgcc taagtaacca cattctcgct tcctccttcc       60

acacacagcc attgggggtt gctcggatcc gggactgccg cagggggtgc cacagcagtg      120

cctggcagcg tgggctggga ccttgtcact aaagcagaga agccacttct tctgggccca      180

cgaggcagct gtcccatgct ctgctgagca cggtggtgcc atgcctctgc aactcctcct      240

gttgctgatc ctactgggcc ctggcaacag cttgcagctg tgggacacct gggcagatga      300

agccgagaaa gccttgggtc ccctgcttgc ccgggaccgg agacaggcca ccgaatatga      360

gtacctagat tatgatttcc tgccagaaac ggagcctcca gaaatgctga ggaacagcac      420

tgacaccact cctctgactg ggcctggaac ccctgagtct accactgtgg agcctgctgc      480

aaggcgttct actggcctgg atgcaggagg ggcagtcaca gagctgacca cggagctggc      540

caacatgggg aacctgtcca cggattcagc agctatggag atacagacca ctcaaccagc      600

agccacggag gcacagacca ctccactggc agccacagag gcacagacaa ctcgactgac      660

ggccacggag gcacagacca ctccactggc agccacagag gcacagacca ctccaccagc      720

agccacggaa gcacagacca ctcaacccac aggcctggag gcacagacca ctgcaccagc      780

agccatggag gcacagacca ctgcaccagc agccatggaa gcacagacca ctccaccagc      840

agccatggag gcacagacca ctcaaaccac agccatggag gcacagacca ctgcaccaga      900

agccacggag gcacagacca ctcaacccac agccacggag gcacagacca ctccactggc      960

agccatggag gccctgtcca cagaacccag tgccacagag gccctgtcca tggaacctac     1020

taccaaaaga ggtctgttca tacccttttc tgtgtcctct gttactcaca agggcattcc     1080

catggcagcc agcaatttgt ccgtcaacta cccagtgggg gccccagacc acatctctgt     1140

gaagcagtgc ctgctggcca tcctaatctt ggcgctggtg gccactatct tcttcgtgtg     1200

cactgtggtg ctggcggtcc gcctctcccg caagggccac atgtaccccg tgcgtaatta     1260

ctcccccacc gagatggtct gcatctcatc cctgttgcct gatgggggtg aggggccctc     1320

tgccacagcc aatgggggcc tgtccaaggc caagagcccg ggcctgacgc cagagcccag     1380

ggaggaccgt gagggggatg acctcaccct gcacagcttc ctcccttagc tcactctgcc     1440

atctgttttg gcaagacccc acctccacgg gctctcctgg gccacccctg agtgcccaga     1500

ccccattcca cagctctggg cttcctcgga gacccctggg gatggggatc ttcagggaag     1560

gaactctggc cacccaaaca ggacaagagc agcctggggc caagcagacg ggcaagtgga     1620

gccacctctt tcctccctcc gcggatgaag cccagccaca tttcagccga ggtccaaggc     1680

aggaggccat ttacttgaga cagattctct cctttttcct gtcccccatc ttctctgggt     1740

ccctctaaca tctcccatgg ctctccccgc ttctcctggt cactggagtc tcctccccat     1800

gtacccaagg aagatggagc tcccccatcc cacacgcact gcactgccat tgtcttttgg     1860

ttgccatggt caccaaacag gaagtggaca ttctaaggga ggagtactga agagtgacgg     1920

acttctgagg ctgtttcctg ctgctcctct gacttggggc agcttgggtc ttcttgggca     1980

cctctctggg aaaacccagg gtgaggttca gcctgtgagg gctgggatgg gtttcgtggg     2040

cccaagggca gacctttctt tgggactgtg tggaccaagg agcttccatc tagtgacaag     2100

tgacccccag ctatcgcctc ttgccttccc ctgtggccac tttccagggt ggactctgtc     2160

ttgttcactg cagtatccca actgcaggtc cagtgcaggc aataaatatg tgatggacaa     2220

acgata                                                                2226


<210>  5
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  5

Gly Phe Ser Phe Thr Gly Tyr Thr Met Asn 
1               5                   10  


<210>  6
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  6

Gly Phe Ser Phe Thr Gly Tyr Thr 
1               5               


<210>  7
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  7

Gly Tyr Thr Met Asn 
1               5   


<210>  8
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  8

Gly Phe Ser Phe Thr Gly Tyr 
1               5           


<210>  9
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  9

Thr Gly Tyr Thr Met Asn 
1               5       


<210>  10
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  10

Leu Ile Ser Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  11

Ile Ser Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  12
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  12

Pro Tyr Asn Gly 
1               


<210>  13
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  13

Trp Ile Gly Leu Ile Ser Pro Tyr Asn Gly Gly Thr Ser 
1               5                   10              


<210>  14
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  14

Leu Ile Ser Pro Tyr Asn Gly Gly Thr Ser 
1               5                   10  


<210>  15
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  15

Arg Ala Tyr Gly Tyr Ala Met Asp Tyr 
1               5                   


<210>  16
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  16

Ala Arg Arg Ala Tyr Gly Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  17

Ala Tyr Gly Tyr Ala Met Asp 
1               5           


<210>  18
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  18

Ala Arg Arg Ala Tyr Gly Tyr Ala Met Asp 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  19

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  20
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  20

Ser Ser Val Ser Tyr 
1               5   


<210>  21
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  21

Ser Ser Ser Val Ser Tyr 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  22

Ser Tyr Met Tyr Trp Tyr 
1               5       


<210>  23
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  23

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  24
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  24

Asp Thr Ser 
1           


<210>  25
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  25

Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala 
1               5                   10  


<210>  26
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  26

Gln Gln Trp Ser Ser Tyr Pro Phe Thr 
1               5                   


<210>  27
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  27

Trp Ser Ser Tyr Pro Phe 
1               5       


<210>  28
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  28

Gln Gln Trp Ser Ser Tyr Pro Phe 
1               5               


<210>  29
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  29

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Val Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ser Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  30
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  30

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Leu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  31
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  31

Leu Ile Ser Pro Tyr Asp Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  32

Ile Ser Pro Tyr Asp Gly Gly Thr 
1               5               


<210>  33
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  33

Leu Ile Ser Pro Tyr Asp Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  34

Trp Ile Gly Leu Ile Ser Pro Tyr Asp Gly Gly Thr Ser 
1               5                   10              


<210>  35
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  35

Leu Ile Ser Pro Tyr Asp Gly Gly Thr Ser 
1               5                   10  


<210>  36
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  36

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Val Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ser Pro Tyr Asp Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  37
<211>  1260
<212>  DNA
<213>  Artificial

<220>
<223>  VISTA-Fc fusion protein

<400>  37
atgggcgtgc ccacagccct ggaagctggc agctggaggt ggggaagcct gctgttcgcc       60

ctgtttctgg ccgcctccct gggacctgtg gccgccttta aggtcgccac cccttacagc      120

ctgtacgtgt gccccgaggg ccagaacgtg accctgacct gcagactgct gggccctgtg      180

gacaagggcc acgacgtgac cttctacaag acctggtaca ggagcagcag gggcgaggtc      240

cagacctgca gcgagaggag gcccatcagg aacctgacct tccaggacct gcacctgcac      300

cacggaggcc atcaggccgc caacacctcc cacgacctgg ctcagaggca cggactggag      360

agcgccagcg atcaccacgg caacttcagc atcaccatga ggaacctcac cctgctggac      420

agcggcctgt actgttgcct ggtggtggag atcaggcacc accacagcga gcacagagtg      480

cacggcgcca tggaactgca ggtgcagacc ggaaaggacg cccccagcaa ctgcgtggtg      540

taccccagca gctcccagga cagcgagaac atcaccgccg ccagatctgt ggagtgccca      600

ccttgcccag caccacctgt ggcaggacct tcagtcttcc tcttcccccc aaaacccaag      660

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      720

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      780

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      840

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaaggcctc      900

ccatcctcca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg      960

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1020

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1080

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1140

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1200

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatga     1260


<210>  38
<211>  416
<212>  PRT
<213>  Artificial

<220>
<223>  VISTA-Fc fusion protein

<400>  38

Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Arg 
            180                 185                 190         


Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
        195                 200                 205             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    210                 215                 220                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
225                 230                 235                 240 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                245                 250                 255     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            260                 265                 270         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        275                 280                 285             


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
    290                 295                 300                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
305                 310                 315                 320 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
                325                 330                 335     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            340                 345                 350         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        355                 360                 365             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    370                 375                 380                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
385                 390                 395                 400 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410                 415     


<210>  39
<211>  521
<212>  PRT
<213>  Artificial

<220>
<223>  Fc-fused PSGL-1 with IgG kappa signal sequence and propeptide 
       sequence

<400>  39

Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn 
1               5                   10                  15      


Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu 
            20                  25                  30          


Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr 
        35                  40                  45              


Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg 
    50                  55                  60                  


Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser 
65                  70                  75                  80  


Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly 
                85                  90                  95      


Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu 
            100                 105                 110         


Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala 
        115                 120                 125             


Thr Glu Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr 
    130                 135                 140                 


Arg Leu Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu 
145                 150                 155                 160 


Ala Gln Thr Thr Pro Pro Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro 
                165                 170                 175     


Thr Gly Leu Glu Ala Gln Thr Thr Ala Pro Ala Ala Met Glu Ala Gln 
            180                 185                 190         


Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Pro Pro Ala Ala 
        195                 200                 205             


Met Glu Ala Gln Thr Thr Gln Thr Thr Ala Met Glu Ala Gln Thr Thr 
    210                 215                 220                 


Ala Pro Glu Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu 
225                 230                 235                 240 


Ala Gln Thr Thr Pro Leu Ala Ala Met Glu Ala Leu Ser Thr Glu Pro 
                245                 250                 255     


Ser Ala Thr Glu Ala Leu Ser Met Glu Pro Thr Thr Lys Arg Gly Leu 
            260                 265                 270         


Phe Ile Pro Phe Ser Val Ser Ser Val Thr His Lys Gly Ile Pro Met 
        275                 280                 285             


Ala Ala Ser Asn Leu Ser Val Ala Arg Ser Val Glu Cys Pro Pro Cys 
    290                 295                 300                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
305                 310                 315                 320 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                325                 330                 335     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            340                 345                 350         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        355                 360                 365             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    370                 375                 380                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
385                 390                 395                 400 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                405                 410                 415     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            420                 425                 430         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        435                 440                 445             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    450                 455                 460                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
465                 470                 475                 480 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                485                 490                 495     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            500                 505                 510         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520     


<210>  40
<211>  523
<212>  PRT
<213>  Artificial

<220>
<223>  Fc-fused PSGL-1 with IgG kappa signal sequence and tandem repeat 
       unit

<400>  40

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gln Ala Thr Glu Tyr Glu Tyr Leu Asp Tyr Asp 
            20                  25                  30          


Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg Asn Ser Thr Asp 
        35                  40                  45              


Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser Thr Thr Val Glu 
    50                  55                  60                  


Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly Gly Ala Val Thr 
65                  70                  75                  80  


Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu Ser Thr Asp Ser 
                85                  90                  95      


Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala Thr Glu Ala Gln 
            100                 105                 110         


Thr Thr Gln Pro Val Pro Thr Glu Ala Gln Thr Thr Pro Leu Ala Ala 
        115                 120                 125             


Thr Glu Ala Gln Thr Thr Arg Leu Thr Ala Thr Glu Ala Gln Thr Thr 
    130                 135                 140                 


Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Pro Pro Ala Ala Thr Glu 
145                 150                 155                 160 


Ala Gln Thr Thr Gln Pro Thr Gly Leu Glu Ala Gln Thr Thr Ala Pro 
                165                 170                 175     


Ala Ala Met Glu Ala Gln Thr Thr Ala Pro Ala Ala Met Glu Ala Gln 
            180                 185                 190         


Thr Thr Pro Pro Ala Ala Met Glu Ala Gln Thr Thr Gln Thr Thr Ala 
        195                 200                 205             


Met Glu Ala Gln Thr Thr Ala Pro Glu Ala Thr Glu Ala Gln Thr Thr 
    210                 215                 220                 


Gln Pro Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu Ala Ala Met Glu 
225                 230                 235                 240 


Ala Leu Ser Thr Glu Pro Ser Ala Thr Glu Ala Leu Ser Met Glu Pro 
                245                 250                 255     


Thr Thr Lys Arg Gly Leu Phe Ile Pro Phe Ser Val Ser Ser Val Thr 
            260                 265                 270         


His Lys Gly Ile Pro Met Ala Ala Ser Asn Leu Ser Val Asn Tyr Pro 
        275                 280                 285             


Val Gly Ala Pro Asp His Ile Ser Val Ala Arg Ser Val Glu Cys Pro 
    290                 295                 300                 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
305                 310                 315                 320 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                325                 330                 335     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            340                 345                 350         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        355                 360                 365             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    370                 375                 380                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
385                 390                 395                 400 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                405                 410                 415     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            420                 425                 430         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        435                 440                 445             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    450                 455                 460                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
465                 470                 475                 480 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                485                 490                 495     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            500                 505                 510         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520             


