                         SEQUENCE LISTING

<110>  Association Institut de Myologie, et al
 
<120>  COMPOSITIONS FOR THE TREATMENT OF SARCOPENIA OR DISUSE ATROPHY

<130>  B2795PC00

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  501
<212>  PRT
<213>  homo sapiens

<400>  1

Met Arg Leu Pro Lys Leu Leu Thr Phe Leu Leu Trp Tyr Leu Ala Trp 
1               5                   10                  15      


Leu Asp Leu Glu Phe Ile Cys Thr Val Leu Gly Ala Pro Asp Leu Gly 
            20                  25                  30          


Gln Arg Pro Gln Gly Thr Arg Pro Gly Leu Ala Lys Ala Glu Ala Lys 
        35                  40                  45              


Glu Arg Pro Pro Leu Ala Arg Asn Val Phe Arg Pro Gly Gly His Ser 
    50                  55                  60                  


Tyr Gly Gly Gly Ala Thr Asn Ala Asn Ala Arg Ala Lys Gly Gly Thr 
65                  70                  75                  80  


Gly Gln Thr Gly Gly Leu Thr Gln Pro Lys Lys Asp Glu Pro Lys Lys 
                85                  90                  95      


Leu Pro Pro Arg Pro Gly Gly Pro Glu Pro Lys Pro Gly His Pro Pro 
            100                 105                 110         


Gln Thr Arg Gln Ala Thr Ala Arg Thr Val Thr Pro Lys Gly Gln Leu 
        115                 120                 125             


Pro Gly Gly Lys Ala Pro Pro Lys Ala Gly Ser Val Pro Ser Ser Phe 
    130                 135                 140                 


Leu Leu Lys Lys Ala Arg Glu Pro Gly Pro Pro Arg Glu Pro Lys Glu 
145                 150                 155                 160 


Pro Phe Arg Pro Pro Pro Ile Thr Pro His Glu Tyr Met Leu Ser Leu 
                165                 170                 175     


Tyr Arg Thr Leu Ser Asp Ala Asp Arg Lys Gly Gly Asn Ser Ser Val 
            180                 185                 190         


Lys Leu Glu Ala Gly Leu Ala Asn Thr Ile Thr Ser Phe Ile Asp Lys 
        195                 200                 205             


Gly Gln Asp Asp Arg Gly Pro Val Val Arg Lys Gln Arg Tyr Val Phe 
    210                 215                 220                 


Asp Ile Ser Ala Leu Glu Lys Asp Gly Leu Leu Gly Ala Glu Leu Arg 
225                 230                 235                 240 


Ile Leu Arg Lys Lys Pro Ser Asp Thr Ala Lys Pro Ala Ala Pro Gly 
                245                 250                 255     


Gly Gly Arg Ala Ala Gln Leu Lys Leu Ser Ser Cys Pro Ser Gly Arg 
            260                 265                 270         


Gln Pro Ala Ser Leu Leu Asp Val Arg Ser Val Pro Gly Leu Asp Gly 
        275                 280                 285             


Ser Gly Trp Glu Val Phe Asp Ile Trp Lys Leu Phe Arg Asn Phe Lys 
    290                 295                 300                 


Asn Ser Ala Gln Leu Cys Leu Glu Leu Glu Ala Trp Glu Arg Gly Arg 
305                 310                 315                 320 


Ala Val Asp Leu Arg Gly Leu Gly Phe Asp Arg Ala Ala Arg Gln Val 
                325                 330                 335     


His Glu Lys Ala Leu Phe Leu Val Phe Gly Arg Thr Lys Lys Arg Asp 
            340                 345                 350         


Leu Phe Phe Asn Glu Ile Lys Ala Arg Ser Gly Gln Asp Asp Lys Thr 
        355                 360                 365             


Val Tyr Glu Tyr Leu Phe Ser Gln Arg Arg Lys Arg Arg Ala Pro Leu 
    370                 375                 380                 


Ala Thr Arg Gln Gly Lys Arg Pro Ser Lys Asn Leu Lys Ala Arg Cys 
385                 390                 395                 400 


Ser Arg Lys Ala Leu His Val Asn Phe Lys Asp Met Gly Trp Asp Asp 
                405                 410                 415     


Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Phe His Cys Glu Gly Leu 
            420                 425                 430         


Cys Glu Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn His Ala Val 
        435                 440                 445             


Ile Gln Thr Leu Met Asn Ser Met Asp Pro Glu Ser Thr Pro Pro Thr 
    450                 455                 460                 


Cys Cys Val Pro Thr Arg Leu Ser Pro Ile Ser Ile Leu Phe Ile Asp 
465                 470                 475                 480 


Ser Ala Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met Val Val Glu 
                485                 490                 495     


Ser Cys Gly Cys Arg 
            500     


<210>  2
<211>  120
<212>  PRT
<213>  homo sapiens

<400>  2

Ala Pro Leu Ala Thr Arg Gln Gly Lys Arg Pro Ser Lys Asn Leu Lys 
1               5                   10                  15      


Ala Arg Cys Ser Arg Lys Ala Leu His Val Asn Phe Lys Asp Met Gly 
            20                  25                  30          


Trp Asp Asp Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Phe His Cys 
        35                  40                  45              


Glu Gly Leu Cys Glu Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn 
    50                  55                  60                  


His Ala Val Ile Gln Thr Leu Met Asn Ser Met Asp Pro Glu Ser Thr 
65                  70                  75                  80  


Pro Pro Thr Cys Cys Val Pro Thr Arg Leu Ser Pro Ile Ser Ile Leu 
                85                  90                  95      


Phe Ile Asp Ser Ala Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met 
            100                 105                 110         


Val Val Glu Ser Cys Gly Cys Arg 
        115                 120 


<210>  3
<211>  120
<212>  PRT
<213>  artificial

<220>
<223>  rhGDF5

<400>  3

Ala Pro Ser Ala Thr Arg Gln Gly Lys Arg Pro Ser Lys Asn Leu Lys 
1               5                   10                  15      


Ala Arg Cys Ser Arg Lys Ala Leu His Val Asn Phe Lys Asp Met Gly 
            20                  25                  30          


Trp Asp Asp Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Phe His Cys 
        35                  40                  45              


Glu Gly Leu Cys Glu Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn 
    50                  55                  60                  


His Ala Val Ile Gln Thr Leu Met Asn Ser Met Asp Pro Glu Ser Thr 
65                  70                  75                  80  


Pro Pro Thr Cys Cys Val Pro Thr Arg Leu Ser Pro Ile Ser Ile Leu 
                85                  90                  95      


Phe Ile Asp Ser Ala Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met 
            100                 105                 110         


Val Val Glu Ser Cys Gly Cys Arg 
        115                 120 


<210>  4
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  4
ctccaagcag atgcagcaga                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  5
atagccttgc gcatcatggt                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  6
agtgagcaag gtggagatcc                                                   20


<210>  7
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  7
gatcgtcggc tggaacac                                                     18


<210>  8
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  8
atgctgacag aaagggaggt aa                                                22


<210>  9
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  9
gcactgatgt caaacacgta cc                                                22


<210>  10
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  10
agaccgtgta tgagtacctg tt                                                22


<210>  11
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  11
gtccttgaag ttgacatgca gt                                                22


<210>  12
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  12
ggcgacctgg aagtccaact                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  13
ccatcagcac cacagccttc                                                   20


<210>  14
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  14
gacagccttc gcctgctgca g                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  15
atgtctgtaa cctcgtagcc c                                                 21


<210>  16
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  16
caggtacagg tgctcacctc                                                   20


<210>  17
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  17
catggcatgt tcctgctcct g                                                 21


<210>  18
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  18
cagggaccct accttgcttc                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  19
gcgaatgtag acgcctcgtc                                                   20


<210>  20
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  20
atggtccaga agagcggcat g                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  21
tggatgttgt atccgaggac g                                                 21


<210>  22
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  22
ggcaagtaca gcaagaggaa ag                                                22


<210>  23
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  23
ttaaggcttc ccggtcctcc                                                   20


<210>  24
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  24
cagccggacc ctggtagtg                                                    19


<210>  25
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  25
gtttggtctt ggctttctcg                                                   20


<210>  26
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  26
cagccggacc ctggtagtg                                                    19


<210>  27
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  27
gaaggggatg cgcttgccgt                                                   20


<210>  28
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  28
gacagccttc gtctgctgca g                                                 21


<210>  29
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  29
gaaggggatg cgcttgccgt                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  30
cagggaccct accttgcttc                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  31
gcggatgtag acgccttgtc                                                   20


<210>  32
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  32
gacagccttc gtctgctgca g                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  33
catgtctgtc acctcatagc c                                                 21


<210>  34
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  34
gttcaaaagg tcagacggg                                                    19


<210>  35
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  35
cagagtctga tggtcggctc gtg                                               23


<210>  36
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  36
caggtacagg tgctcacct                                                    19


<210>  37
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  37
catggcgtgc tcctgaggct g                                                 21


<210>  38
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  38
cagggaccct accttgcttc                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  39
catcaaaggt gtcttggcgg                                                   20


<210>  40
<211>  1929
<212>  DNA
<213>  Mus musculus

<400>  40
atggtccaga agagcggcat gtcccggggc ccttacccac cttcccaaga gatccctatg       60

gaggtcttcg accccagccc acagggcaag tacagcaaga ggaaagggcg gttcaaaagg      120

tcagacggga gtacgtcctc ggatacaaca tccaacagct tcgtccgcca gggctcagca      180

gagtcctaca cgagccgacc atcagactct gatgtgtctc tggaggagga ccgggaagcc      240

ttaaggaagg aggcagagcg ccaggcctta gcccagctcg agaaagccaa gaccaaacca      300

gtggcttttg ctgttcggac aaatgttggc tacaatccgt ctccagggga tgaggtgcct      360

gtacagggag tggccatcac ctttgagccc aaggacttcc tacacatcaa ggagaagtac      420

aataatgact ggtggattgg gcggctggtg aaggaaggct gcgaggttgg cttcatcccc      480

agcccggtca aactggacag ccttcgtctg ctgcaggaac agaccctgcg ccagaaccgc      540

ctcagctcca gcaagtcagg tgacaactcc agttccagtc tgggagatgt ggtgactggc      600

acccgccgcc ccacaccccc tgccagtggt aatgaaatga ctaactttgc ctttgagcta      660

gaccccctag agttagagga ggaggaggca gagctagggg agcacggcgg ctcagccaag      720

actagcgtga gcagtgtcac cacgccgcca ccccacggca agcgcatccc cttctttaag      780

aagacagagc acgtgccccc ctatgacgtg gtgccttcca tgaggcccat catcctggtg      840

ggaccgtcgc tcaagggcta tgaggtgaca gacatgatgc agaaagcgtt gtttgacttc      900

ctcaagcatc ggtttgatgg caggatttcc atcacccggg taacagctga catttccctg      960

gccaaacgct ccgtcctcaa caaccccagc aaacacatca tcattgagcg ctccaacacg     1020

cgttccagcc tggctgaggt acagagtgaa attgagagga tcttcgagct ggcccggacc     1080

ttgcagctgg tcgccttgga cgctgacacc atcaaccacc cagcccagct ctctaaaacg     1140

tcgctggccc ccatcattgt ttacatcaag atcacatctc ccaaggtact gcagaggctc     1200

atcaaatccc gagggaagtc tcaatccaaa cacctcaatg tccaaatagc agcctcggag     1260

aagctggcac agtgtccccc cgaaatgttt gacataatcc tggacgagaa ccaattggaa     1320

gatgcctgcg agcacctggc tgagtacttg gaagcctact ggaaggccac acatccgcct     1380

agcagcacgc cacccaatcc gctgctgaac cgcaccatgg ctaccgcagc tctggctgcc     1440

agccctgccc ccgtctccaa cctccaggga ccctaccttg cttccgggga ccagccgctg     1500

gaccgggcca ctggggaaca tgccagtgtg cacgagtacc ccggggaact gggccagccc     1560

ccaggccttt accccagcaa ccacccacct ggccgggcag gcaccctgcg ggcgctatcc     1620

cgccaagaca cctttgatgc tgacaccccc ggcagccgaa attctgccta cacggagccg     1680

ggagactcgt gtgtggacat ggagacagac ccctcagagg gcccagggcc tggagaccct     1740

gcagggggag gcacaccacc agcccggcag ggctcctggg aagacgagga agactatgag     1800

gaggagatga ccgacaacag gaaccggggc cggaataagg cccgctactg tgcggagggt     1860

ggtgggccgg ttctggggcg caataagaat gagctggagg gctggggaca aggcgtctac     1920

atccgctga                                                             1929


<210>  41
<211>  1434
<212>  DNA
<213>  Mus musculus

<400>  41
atggaggtgc ccagccggac cctggtagtg ggctcagcag agtcctacac gagccgacca       60

tcagactctg atgtgtctct ggaggaggac cgggaagcct taaggaagga ggcagagcgc      120

caggccttag cccagctcga gaaagccaag accaaaccag tggcttttgc tgttcggaca      180

aatgttggct acaatccgtc tccaggggat gaggtgcctg tacagggagt ggccatcacc      240

tttgagccca aggacttcct acacatcaag gagaagtaca ataatgactg gtggattggg      300

cggctggtga aggaaggctg cgaggttggc ttcatcccca gcccggtcaa actggacagc      360

cttcgtctgc tgcaggaaca gaccctgcgc cagaaccgcc tcagctccag caagtcaggt      420

gacaactcca gttccagtct gggagatgtg gtgactggca cccgccgccc cacaccccct      480

gccagtggta atgaaatgac taactttgcc tttgagctag accccctaga gttagaggag      540

gaggaggcag agctagggga gcacggcggc tcagccaaga ctagcgtgag cagtgtcacc      600

acgccgccac cccacggcaa gcgcatcccc ttctttaaga agacagagca cgtgcccccc      660

tatgacgtgg tgccttccat gaggcccatc atcctggtgg gaccgtcgct caagggctat      720

gaggtgacag acatgatgca gaaagcgttg tttgacttcc tcaagcatcg gtttgatggc      780

aggatttcca tcacccgggt aacagctgac atttccctgg ccaaacgctc cgtcctcaac      840

aaccccagca aacacatcat cattgagcgc tccaacacgc gttccagcct ggctgaggta      900

cagagtgaaa ttgagaggat cttcgagctg gcccggacct tgcagctggt cgccttggac      960

gctgacacca tcaaccaccc agcccagctc tctaaaacgt cgctggcccc catcattgtt     1020

tacatcaaga tcacatctcc caaggtactg cagaggctca tcaaatcccg agggaagtct     1080

caatccaaac acctcaatgt ccaaatagca gcctcggaga agctggcaca gtgtcccccc     1140

gaaatgtttg acataatcct ggacgagaac caattggaag atgcctgcga gcacctggct     1200

gagtacttgg aagcctactg gaaggccaca catccgccta gcagcacgcc acccaatccg     1260

ctgctgaacc gcaccatggc taccgcagct ctggctgcca gccctgcccc cgtctccaac     1320

ctccaggtac aggtgctcac ctcgctcagg agaaatctca gcttctgggg cgggctggag     1380

gcctcaccgc ggggaggcga cgcggtggcc cagcctcagg agcacgccat gtag           1434


<210>  42
<211>  642
<212>  PRT
<213>  Mus musculus

<400>  42

Met Val Gln Lys Ser Gly Met Ser Arg Gly Pro Tyr Pro Pro Ser Gln 
1               5                   10                  15      


Glu Ile Pro Met Glu Val Phe Asp Pro Ser Pro Gln Gly Lys Tyr Ser 
            20                  25                  30          


Lys Arg Lys Gly Arg Phe Lys Arg Ser Asp Gly Ser Thr Ser Ser Asp 
        35                  40                  45              


Thr Thr Ser Asn Ser Phe Val Arg Gln Gly Ser Ala Glu Ser Tyr Thr 
    50                  55                  60                  


Ser Arg Pro Ser Asp Ser Asp Val Ser Leu Glu Glu Asp Arg Glu Ala 
65                  70                  75                  80  


Leu Arg Lys Glu Ala Glu Arg Gln Ala Leu Ala Gln Leu Glu Lys Ala 
                85                  90                  95      


Lys Thr Lys Pro Val Ala Phe Ala Val Arg Thr Asn Val Gly Tyr Asn 
            100                 105                 110         


Pro Ser Pro Gly Asp Glu Val Pro Val Gln Gly Val Ala Ile Thr Phe 
        115                 120                 125             


Glu Pro Lys Asp Phe Leu His Ile Lys Glu Lys Tyr Asn Asn Asp Trp 
    130                 135                 140                 


Trp Ile Gly Arg Leu Val Lys Glu Gly Cys Glu Val Gly Phe Ile Pro 
145                 150                 155                 160 


Ser Pro Val Lys Leu Asp Ser Leu Arg Leu Leu Gln Glu Gln Thr Leu 
                165                 170                 175     


Arg Gln Asn Arg Leu Ser Ser Ser Lys Ser Gly Asp Asn Ser Ser Ser 
            180                 185                 190         


Ser Leu Gly Asp Val Val Thr Gly Thr Arg Arg Pro Thr Pro Pro Ala 
        195                 200                 205             


Ser Gly Asn Glu Met Thr Asn Phe Ala Phe Glu Leu Asp Pro Leu Glu 
    210                 215                 220                 


Leu Glu Glu Glu Glu Ala Glu Leu Gly Glu His Gly Gly Ser Ala Lys 
225                 230                 235                 240 


Thr Ser Val Ser Ser Val Thr Thr Pro Pro Pro His Gly Lys Arg Ile 
                245                 250                 255     


Pro Phe Phe Lys Lys Thr Glu His Val Pro Pro Tyr Asp Val Val Pro 
            260                 265                 270         


Ser Met Arg Pro Ile Ile Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu 
        275                 280                 285             


Val Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg 
    290                 295                 300                 


Phe Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Ile Ser Leu 
305                 310                 315                 320 


Ala Lys Arg Ser Val Leu Asn Asn Pro Ser Lys His Ile Ile Ile Glu 
                325                 330                 335     


Arg Ser Asn Thr Arg Ser Ser Leu Ala Glu Val Gln Ser Glu Ile Glu 
            340                 345                 350         


Arg Ile Phe Glu Leu Ala Arg Thr Leu Gln Leu Val Ala Leu Asp Ala 
        355                 360                 365             


Asp Thr Ile Asn His Pro Ala Gln Leu Ser Lys Thr Ser Leu Ala Pro 
    370                 375                 380                 


Ile Ile Val Tyr Ile Lys Ile Thr Ser Pro Lys Val Leu Gln Arg Leu 
385                 390                 395                 400 


Ile Lys Ser Arg Gly Lys Ser Gln Ser Lys His Leu Asn Val Gln Ile 
                405                 410                 415     


Ala Ala Ser Glu Lys Leu Ala Gln Cys Pro Pro Glu Met Phe Asp Ile 
            420                 425                 430         


Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Glu 
        435                 440                 445             


Tyr Leu Glu Ala Tyr Trp Lys Ala Thr His Pro Pro Ser Ser Thr Pro 
    450                 455                 460                 


Pro Asn Pro Leu Leu Asn Arg Thr Met Ala Thr Ala Ala Leu Ala Ala 
465                 470                 475                 480 


Ser Pro Ala Pro Val Ser Asn Leu Gln Gly Pro Tyr Leu Ala Ser Gly 
                485                 490                 495     


Asp Gln Pro Leu Asp Arg Ala Thr Gly Glu His Ala Ser Val His Glu 
            500                 505                 510         


Tyr Pro Gly Glu Leu Gly Gln Pro Pro Gly Leu Tyr Pro Ser Asn His 
        515                 520                 525             


Pro Pro Gly Arg Ala Gly Thr Leu Arg Ala Leu Ser Arg Gln Asp Thr 
    530                 535                 540                 


Phe Asp Ala Asp Thr Pro Gly Ser Arg Asn Ser Ala Tyr Thr Glu Pro 
545                 550                 555                 560 


Gly Asp Ser Cys Val Asp Met Glu Thr Asp Pro Ser Glu Gly Pro Gly 
                565                 570                 575     


Pro Gly Asp Pro Ala Gly Gly Gly Thr Pro Pro Ala Arg Gln Gly Ser 
            580                 585                 590         


Trp Glu Asp Glu Glu Asp Tyr Glu Glu Glu Met Thr Asp Asn Arg Asn 
        595                 600                 605             


Arg Gly Arg Asn Lys Ala Arg Tyr Cys Ala Glu Gly Gly Gly Pro Val 
    610                 615                 620                 


Leu Gly Arg Asn Lys Asn Glu Leu Glu Gly Trp Gly Gln Gly Val Tyr 
625                 630                 635                 640 


Ile Arg 
        


<210>  43
<211>  477
<212>  PRT
<213>  Mus musculus

<400>  43

Met Glu Val Pro Ser Arg Thr Leu Val Val Gly Ser Ala Glu Ser Tyr 
1               5                   10                  15      


Thr Ser Arg Pro Ser Asp Ser Asp Val Ser Leu Glu Glu Asp Arg Glu 
            20                  25                  30          


Ala Leu Arg Lys Glu Ala Glu Arg Gln Ala Leu Ala Gln Leu Glu Lys 
        35                  40                  45              


Ala Lys Thr Lys Pro Val Ala Phe Ala Val Arg Thr Asn Val Gly Tyr 
    50                  55                  60                  


Asn Pro Ser Pro Gly Asp Glu Val Pro Val Gln Gly Val Ala Ile Thr 
65                  70                  75                  80  


Phe Glu Pro Lys Asp Phe Leu His Ile Lys Glu Lys Tyr Asn Asn Asp 
                85                  90                  95      


Trp Trp Ile Gly Arg Leu Val Lys Glu Gly Cys Glu Val Gly Phe Ile 
            100                 105                 110         


Pro Ser Pro Val Lys Leu Asp Ser Leu Arg Leu Leu Gln Glu Gln Thr 
        115                 120                 125             


Leu Arg Gln Asn Arg Leu Ser Ser Ser Lys Ser Gly Asp Asn Ser Ser 
    130                 135                 140                 


Ser Ser Leu Gly Asp Val Val Thr Gly Thr Arg Arg Pro Thr Pro Pro 
145                 150                 155                 160 


Ala Ser Gly Asn Glu Met Thr Asn Phe Ala Phe Glu Leu Asp Pro Leu 
                165                 170                 175     


Glu Leu Glu Glu Glu Glu Ala Glu Leu Gly Glu His Gly Gly Ser Ala 
            180                 185                 190         


Lys Thr Ser Val Ser Ser Val Thr Thr Pro Pro Pro His Gly Lys Arg 
        195                 200                 205             


Ile Pro Phe Phe Lys Lys Thr Glu His Val Pro Pro Tyr Asp Val Val 
    210                 215                 220                 


Pro Ser Met Arg Pro Ile Ile Leu Val Gly Pro Ser Leu Lys Gly Tyr 
225                 230                 235                 240 


Glu Val Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His 
                245                 250                 255     


Arg Phe Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Ile Ser 
            260                 265                 270         


Leu Ala Lys Arg Ser Val Leu Asn Asn Pro Ser Lys His Ile Ile Ile 
        275                 280                 285             


Glu Arg Ser Asn Thr Arg Ser Ser Leu Ala Glu Val Gln Ser Glu Ile 
    290                 295                 300                 


Glu Arg Ile Phe Glu Leu Ala Arg Thr Leu Gln Leu Val Ala Leu Asp 
305                 310                 315                 320 


Ala Asp Thr Ile Asn His Pro Ala Gln Leu Ser Lys Thr Ser Leu Ala 
                325                 330                 335     


Pro Ile Ile Val Tyr Ile Lys Ile Thr Ser Pro Lys Val Leu Gln Arg 
            340                 345                 350         


Leu Ile Lys Ser Arg Gly Lys Ser Gln Ser Lys His Leu Asn Val Gln 
        355                 360                 365             


Ile Ala Ala Ser Glu Lys Leu Ala Gln Cys Pro Pro Glu Met Phe Asp 
    370                 375                 380                 


Ile Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala 
385                 390                 395                 400 


Glu Tyr Leu Glu Ala Tyr Trp Lys Ala Thr His Pro Pro Ser Ser Thr 
                405                 410                 415     


Pro Pro Asn Pro Leu Leu Asn Arg Thr Met Ala Thr Ala Ala Leu Ala 
            420                 425                 430         


Ala Ser Pro Ala Pro Val Ser Asn Leu Gln Val Gln Val Leu Thr Ser 
        435                 440                 445             


Leu Arg Arg Asn Leu Ser Phe Trp Gly Gly Leu Glu Ala Ser Pro Arg 
    450                 455                 460                 


Gly Gly Asp Ala Val Ala Gln Pro Gln Glu His Ala Met 
465                 470                 475         


<210>  44
<211>  1929
<212>  DNA
<213>  Mus musculus

<400>  44
atggtccaga agagcggcat gtcccggggc ccttacccac cttcccaaga gatccctatg       60

gaggtcttcg accccagccc acagggcaag tacagcaaga ggaaagggcg gttcaaaagg      120

tcagacggga gtacgtcctc ggatacaaca tccaacagct tcgtccgcca gggctcagca      180

gagtcctaca cgagccgacc atcagactct gatgtgtctc tggaggagga ccgggaagcc      240

ttaaggaagg aggcagagcg ccaggcctta gcccagctcg agaaagccaa gaccaaacca      300

gtggcttttg ctgttcggac aaatgttggc tacaatccgt ctccagggga tgaggtgcct      360

gtacagggag tggccatcac ctttgagccc aaggacttcc tacacatcaa ggagaagtac      420

aataatgact ggtggattgg gcggctggtg aaggaaggct gcgaggttgg cttcatcccc      480

agcccggtca aactggacag ccttcgtctg ctgcaggaac agaccctgcg ccagaaccgc      540

ctcagctcca gcaagtcagg tgacaactcc agttccagtc tgggagatgt ggtgactggc      600

acccgccgcc ccacaccccc tgccagtggt aatgaaatga ctaactttgc ctttgagcta      660

gaccccctag agttagagga ggaggaggca gagctagggg agcacggcgg ctcagccaag      720

actagcgtga gcagtgtcac cacgccgcca ccccacggca agcgcatccc cttctttaag      780

aagacagagc acgtgccccc ctatgacgtg gtgccttcca tgaggcccat catcctggtg      840

ggaccgtcgc tcaagggcta tgaggtgaca gacatgatgc agaaagcgtt gtttgacttc      900

ctcaagcatc ggtttgatgg caggatttcc atcacccggg taacagctga catttccctg      960

gccaaacgct ccgtcctcaa caaccccagc aaacacatca tcattgagcg ctccaacacg     1020

cgttccagcc tggctgaggt acagagtgaa attgagagga tcttcgagct ggcccggacc     1080

ttgcagctgg tcgccttgga cgctgacacc atcaaccacc cagcccagct ctctaaaacg     1140

tcgctggccc ccatcattgt ttacatcaag atcacatctc ccaaggtact gcagaggctc     1200

atcaaatccc gagggaagtc tcaatccaaa cacctcaatg tccaaatagc agcctcggag     1260

aagctggcac agtgtccccc cgaaatgttt gacataatcc tggacgagaa ccaattggaa     1320

gatgcctgcg agcacctggc tgagtacttg gaagcctact ggaaggccac acatccgcct     1380

agcagcacgc cacccaatcc gctgctgaac cgcaccatgg ctaccgcagc tctggctgcc     1440

agccctgccc ccgtctccaa cctccaggga ccctaccttg cttccgggga ccagccgctg     1500

gaccgggcca ctggggaaca tgccagtgtg cacgagtacc ccggggaact gggccagccc     1560

ccaggccttt accccagcaa ccacccacct ggccgggcag gcaccctgcg ggcgctatcc     1620

cgccaagaca cctttgatgc tgacaccccc ggcagccgaa attctgccta cacggagccg     1680

ggagactcgt gtgtggacat ggagacagac ccctcagagg gcccagggcc tggagaccct     1740

gcagggggag gcacaccacc agcccggcag ggctcctggg aagacgagga agactatgag     1800

gaggagatga ccgacaacag gaaccggggc cggaataagg cccgctactg tgcggagggt     1860

ggtgggccgg ttctggggcg caataagaat gagctggagg gctggggaca aggcgtctac     1920

atccgctga                                                             1929


<210>  45
<211>  1794
<212>  DNA
<213>  Mus musculus

<400>  45
atggtccaga agagcggcat gtcccggggc ccttacccac cttcccaaga gatccctatg       60

gaggtcttcg accccagccc acagggcaag tacagcaaga ggaaagggcg gttcaaaagg      120

tcagacggga gtacgtcctc ggatacaaca tccaacagct tcgtccgcca gggctcagca      180

gagtcctaca cgagccgacc atcagactct gatgtgtctc tggaggagga ccgggaagcc      240

ttaaggaagg aggcagagcg ccaggcctta gcccagctcg agaaagccaa gaccaaacca      300

gtggcttttg ctgttcggac aaatgttggc tacaatccgt ctccagggga tgaggtgcct      360

gtacagggag tggccatcac ctttgagccc aaggacttcc tacacatcaa ggagaagtac      420

aataatgact ggtggattgg gcggctggtg aaggaaggct gcgaggttgg cttcatcccc      480

agcccggtca aactggacag ccttcgtctg ctgcaggaac agaccctgcg ccagaaccgc      540

ctcagctcca gcaagtcagg tgacaactcc agttccagtc tgggagatgt ggtgactggc      600

acccgccgcc ccacaccccc tgccagtgcc aaacagaagc agaaatcgac agagcacgtg      660

cccccctatg acgtggtgcc ttccatgagg cccatcatcc tggtgggacc gtcgctcaag      720

ggctatgagg tgacagacat gatgcagaaa gcgttgtttg acttcctcaa gcatcggttt      780

gatggcagga tttccatcac ccgggtaaca gctgacattt ccctggccaa acgctccgtc      840

ctcaacaacc ccagcaaaca catcatcatt gagcgctcca acacgcgttc cagcctggct      900

gaggtacaga gtgaaattga gaggatcttc gagctggccc ggaccttgca gctggtcgcc      960

ttggacgctg acaccatcaa ccacccagcc cagctctcta aaacgtcgct ggcccccatc     1020

attgtttaca tcaagatcac atctcccaag gtactgcaga ggctcatcaa atcccgaggg     1080

aagtctcaat ccaaacacct caatgtccaa atagcagcct cggagaagct ggcacagtgt     1140

ccccccgaaa tgtttgacat aatcctggac gagaaccaat tggaagatgc ctgcgagcac     1200

ctggctgagt acttggaagc ctactggaag gccacacatc cgcctagcag cacgccaccc     1260

aatccgctgc tgaaccgcac catggctacc gcagctctgg ctgccagccc tgcccccgtc     1320

tccaacctcc agggacccta ccttgcttcc ggggaccagc cgctggaccg ggccactggg     1380

gaacatgcca gtgtgcacga gtaccccggg gaactgggcc agcccccagg cctttacccc     1440

agcaaccacc cacctggccg ggcaggcacc ctgcgggcgc tatcccgcca agacaccttt     1500

gatgctgaca cccccggcag ccgaaattct gcctacacgg agccgggaga ctcgtgtgtg     1560

gacatggaga cagacccctc agagggccca gggcctggag accctgcagg gggaggcaca     1620

ccaccagccc ggcagggctc ctgggaagac gaggaagact atgaggagga gatgaccgac     1680

aacaggaacc ggggccggaa taaggcccgc tactgtgcgg agggtggtgg gccggttctg     1740

gggcgcaata agaatgagct ggagggctgg ggacaaggcg tctacatccg ctga           1794


