                         SEQUENCE LISTING

<110>  PEACCEL
 
<120>  Method and electronic system for predicting at least one fitness 
       value of a protein via an extended numerical sequence, related 
       computer program product

<130>  BET 19P3673

<150>  EP18305994.8
<151>  2018-07-20

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  464
<212>  PRT
<213>  Bacillus megaterium

<400>  1

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Val Arg 
65                  70                  75                  80  


Asp Phe Ala Gly Asp Gly Leu Ala Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Pro Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Thr 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Ala Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Phe Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Ser Gly Glu Gln Ser Asp Asp Leu Leu Thr His Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Glu Asn Ile Arg 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Ala Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Leu Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


<210>  2
<211>  466
<212>  PRT
<213>  Bacillus megaterium

<400>  2

Lys Glu Thr Ser Pro Ile Pro Gln Pro Lys Thr Phe Gly Pro Leu Gly 
1               5                   10                  15      


Asn Leu Pro Leu Ile Asp Lys Asp Lys Pro Thr Leu Ser Leu Ile Lys 
            20                  25                  30          


Leu Ala Glu Glu Gln Gly Pro Ile Phe Gln Ile His Thr Pro Ala Gly 
        35                  40                  45              


Thr Thr Ile Val Val Ser Gly His Glu Leu Val Lys Glu Val Cys Asp 
    50                  55                  60                  


Glu Glu Arg Phe Asp Lys Ser Ile Glu Gly Ala Leu Glu Lys Val Arg 
65                  70                  75                  80  


Ala Phe Ser Gly Asp Gly Leu Ala Thr Ser Trp Thr His Glu Pro Asn 
                85                  90                  95      


Trp Arg Lys Ala His Asn Ile Leu Met Pro Thr Phe Ser Gln Arg Ala 
            100                 105                 110         


Met Lys Asp Tyr His Glu Lys Met Val Asp Ile Ala Val Gln Leu Ile 
        115                 120                 125             


Gln Lys Trp Ala Arg Leu Asn Pro Asn Glu Ala Val Asp Val Pro Gly 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Tyr Tyr Arg Glu Thr Pro His Pro Phe Ile Asn 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Ala Met His Gln Met Gln Arg Leu 
            180                 185                 190         


Asp Val Gln Asp Lys Leu Met Val Arg Thr Lys Arg Gln Phe Arg Tyr 
        195                 200                 205             


Asp Ile Gln Thr Met Phe Ser Leu Val Asp Ser Ile Ile Ala Glu Arg 
    210                 215                 220                 


Arg Ala Asn Gly Asp Gln Asp Glu Lys Asp Leu Leu Ala Arg Met Leu 
225                 230                 235                 240 


Asn Val Glu Asp Pro Glu Thr Gly Glu Lys Leu Asp Asp Glu Asn Ile 
                245                 250                 255     


Arg Phe Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser 
            260                 265                 270         


Gly Leu Leu Ser Phe Ala Thr Tyr Phe Leu Leu Lys His Pro Asp Lys 
        275                 280                 285             


Leu Lys Lys Ala Tyr Glu Glu Val Asp Arg Val Leu Thr Asp Ala Ala 
    290                 295                 300                 


Pro Thr Tyr Lys Gln Val Leu Glu Leu Thr Tyr Ile Arg Met Ile Leu 
305                 310                 315                 320 


Asn Glu Ser Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr 
                325                 330                 335     


Pro Lys Glu Asp Thr Val Ile Gly Gly Lys Phe Pro Ile Thr Thr Asn 
            340                 345                 350         


Asp Arg Ile Ser Val Leu Ile Pro Gln Leu His Arg Asp Arg Asp Ala 
        355                 360                 365             


Trp Gly Lys Asp Ala Glu Glu Phe Arg Pro Glu Arg Phe Glu His Gln 
    370                 375                 380                 


Asp Gln Val Pro His His Ala Tyr Lys Pro Phe Gly Asn Gly Gln Arg 
385                 390                 395                 400 


Ala Cys Ile Gly Met Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu 
                405                 410                 415     


Gly Met Ile Leu Lys Tyr Phe Thr Leu Ile Asp His Glu Asn Tyr Glu 
            420                 425                 430         


Leu Asp Ile Lys Gln Thr Leu Thr Leu Lys Pro Gly Asp Phe His Ile 
        435                 440                 445             


Ser Val Gln Ser Arg His Gln Glu Ala Ile His Ala Asp Val Gln Ala 
    450                 455                 460                 


Ala Glu 
465     


<210>  3
<211>  466
<212>  PRT
<213>  Bacillus megaterium

<400>  3

Lys Gln Ala Ser Ala Ile Pro Gln Pro Lys Thr Tyr Gly Pro Leu Lys 
1               5                   10                  15      


Asn Leu Pro His Leu Glu Lys Glu Gln Leu Ser Gln Ser Leu Trp Arg 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Pro Ile Phe Arg Phe Asp Phe Pro Gly Val 
        35                  40                  45              


Ser Ser Val Phe Val Ser Gly His Asn Leu Val Ala Glu Val Cys Asp 
    50                  55                  60                  


Glu Lys Arg Phe Asp Lys Asn Leu Gly Lys Gly Leu Gln Lys Val Arg 
65                  70                  75                  80  


Glu Phe Gly Gly Asp Gly Leu Ala Thr Ser Trp Thr His Glu Pro Asn 
                85                  90                  95      


Trp Gln Lys Ala His Arg Ile Leu Leu Pro Ser Phe Ser Gln Lys Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ser Met Met Leu Asp Ile Ala Thr Gln Leu Ile 
        115                 120                 125             


Gln Lys Trp Ser Arg Leu Asn Pro Asn Glu Glu Ile Asp Val Ala Asp 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Ser Gln His Pro Phe Ile Thr 
                165                 170                 175     


Ser Met Leu Arg Ala Leu Lys Glu Ala Met Asn Gln Ser Lys Arg Leu 
            180                 185                 190         


Gly Leu Gln Asp Lys Met Met Val Lys Thr Lys Leu Gln Phe Gln Lys 
        195                 200                 205             


Asp Ile Glu Val Met Asn Ser Leu Val Asp Arg Met Ile Ala Glu Arg 
    210                 215                 220                 


Lys Ala Asn Pro Asp Glu Asn Ile Lys Asp Leu Leu Ser Leu Met Leu 
225                 230                 235                 240 


Tyr Ala Lys Asp Pro Val Thr Gly Glu Thr Leu Asp Asp Glu Asn Ile 
                245                 250                 255     


Arg Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser 
            260                 265                 270         


Gly Leu Leu Ser Phe Ala Ile Tyr Cys Leu Leu Thr His Pro Glu Lys 
        275                 280                 285             


Leu Lys Lys Ala Gln Glu Glu Ala Asp Arg Val Leu Thr Asp Asp Thr 
    290                 295                 300                 


Pro Glu Tyr Lys Gln Ile Gln Gln Leu Lys Tyr Ile Arg Met Val Leu 
305                 310                 315                 320 


Asn Glu Thr Leu Arg Leu Tyr Pro Thr Ala Pro Ala Phe Ser Leu Tyr 
                325                 330                 335     


Ala Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Ile Ser Lys Gly 
            340                 345                 350         


Gln Pro Val Thr Val Leu Ile Pro Lys Leu His Arg Asp Gln Asn Ala 
        355                 360                 365             


Trp Gly Pro Asp Ala Glu Asp Phe Arg Pro Glu Arg Phe Glu Asp Pro 
    370                 375                 380                 


Ser Ser Ile Pro His His Ala Tyr Lys Pro Phe Gly Asn Gly Gln Arg 
385                 390                 395                 400 


Ala Cys Ile Gly Met Gln Phe Ala Leu Gln Glu Ala Thr Met Val Leu 
                405                 410                 415     


Gly Leu Val Leu Lys His Phe Glu Leu Ile Asn His Thr Gly Tyr Glu 
            420                 425                 430         


Leu Lys Ile Lys Glu Ala Leu Thr Ile Lys Pro Asp Asp Phe Lys Ile 
        435                 440                 445             


Thr Val Lys Pro Arg Lys Thr Ala Ala Ile Asn Val Gln Arg Lys Glu 
    450                 455                 460                 


Gln Ala 
465     


<210>  4
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  4

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  5
<211>  398
<212>  PRT
<213>  Aspergillus niger

<400>  5

Asn His Lys Ala Phe Ala Lys Phe Pro Ser Ser Ala Ser Ile Ser Pro 
1               5                   10                  15      


Asn Pro Phe Thr Val Ser Ile Pro Asp Glu Gln Leu Asp Asp Leu Lys 
            20                  25                  30          


Thr Leu Val Arg Leu Ser Lys Ile Ala Pro Pro Thr Tyr Glu Ser Leu 
        35                  40                  45              


Gln Ala Asp Gly Arg Phe Gly Ile Thr Ser Glu Trp Leu Thr Thr Met 
    50                  55                  60                  


Arg Glu Lys Trp Leu Ser Glu Phe Asp Trp Arg Pro Phe Glu Ala Arg 
65                  70                  75                  80  


Leu Asn Ser Phe Pro Gln Phe Thr Thr Glu Ile Glu Gly Leu Thr Ile 
                85                  90                  95      


His Phe Ala Ala Leu Phe Ser Glu Arg Glu Asp Ala Val Pro Ile Ala 
            100                 105                 110         


Leu Leu His Gly Trp Pro Gly Ser Phe Val Glu Phe Tyr Pro Ile Leu 
        115                 120                 125             


Gln Leu Phe Arg Glu Glu Tyr Thr Pro Glu Thr Leu Pro Phe His Leu 
    130                 135                 140                 


Val Val Pro Ser Leu Pro Gly Tyr Thr Phe Ser Ser Gly Pro Pro Leu 
145                 150                 155                 160 


Asp Lys Asp Phe Gly Leu Met Asp Asn Ala Arg Val Val Asp Gln Leu 
                165                 170                 175     


Met Lys Asp Leu Gly Phe Gly Ser Gly Tyr Ile Ile Gln Gly Gly Asp 
            180                 185                 190         


Ile Gly Ser Phe Val Gly Arg Leu Leu Gly Val Gly Phe Asp Ala Cys 
        195                 200                 205             


Lys Ala Val His Leu Asn Leu Cys Ala Met Arg Ala Pro Pro Glu Gly 
    210                 215                 220                 


Pro Ser Ile Glu Ser Leu Ser Ala Ala Glu Lys Glu Gly Ile Ala Arg 
225                 230                 235                 240 


Met Glu Lys Phe Met Thr Asp Gly Leu Ala Tyr Ala Met Glu His Ser 
                245                 250                 255     


Thr Arg Pro Ser Thr Ile Gly His Val Leu Ser Ser Ser Pro Ile Ala 
            260                 265                 270         


Leu Leu Ala Trp Ile Gly Glu Lys Tyr Leu Gln Trp Val Asp Lys Pro 
        275                 280                 285             


Leu Pro Ser Glu Thr Ile Leu Glu Met Val Ser Leu Tyr Trp Leu Thr 
    290                 295                 300                 


Glu Ser Phe Pro Arg Ala Ile His Thr Tyr Arg Glu Thr Thr Pro Thr 
305                 310                 315                 320 


Ala Ser Ala Pro Asn Gly Ala Thr Met Leu Gln Lys Glu Leu Tyr Ile 
                325                 330                 335     


His Lys Pro Phe Gly Phe Ser Phe Phe Pro Lys Asp Leu Cys Pro Val 
            340                 345                 350         


Pro Arg Ser Trp Ile Ala Thr Thr Gly Asn Leu Val Phe Phe Arg Asp 
        355                 360                 365             


His Ala Glu Gly Gly His Phe Ala Ala Leu Glu Arg Pro Arg Glu Leu 
    370                 375                 380                 


Lys Thr Asp Leu Thr Ala Phe Val Glu Gln Val Trp Gln Lys 
385                 390                 395             


<210>  6
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  6

Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
            20                  25                  30          


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
        35                  40                  45              


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
65                  70                  75                  80  


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
                85                  90                  95      


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
            100                 105                 110         


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
        115                 120                 125             


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe 
    130                 135                 140                 


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 155         


