
                                SEQUENCE LISTING

<110> TAYU HUAXIA Biotech Medical Group Co., Ltd.
 
<120> ANTI-PD-1 ANTIBODIES, DOSAGES AND USES THEREOF

<130> 79257-20009.40

<140> Not Yet Assigned
<141> Concurrently Herewith

<150> PCT/CN2018/096206
<151> 2018-07-19

<160> 67

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 1
Gly Phe Thr Phe Ser Ser Tyr Thr
 1               5              


<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 2
Ile Ser His Gly Gly Gly Asp Thr
 1               5              


<210> 3
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 3
Ala Arg His Ser Gly Tyr Glu Arg Gly Tyr Tyr Tyr Val Met Asp Tyr
 1               5                  10                  15      


<210> 4
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
Glu Ser Val Asp Tyr Tyr Gly Phe Ser Phe
 1               5                  10  


<210> 5
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
Ala Ala Ser
 1          


<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 6
Gln Gln Ser Lys Glu Val Pro Trp
 1               5              


<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
Gly Tyr Thr Phe Thr Ser Tyr Thr
 1               5              


<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 8
Ile Asn Pro Thr Thr Gly Tyr Thr
 1               5              


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 9
Ala Arg Asp Asp Ala Tyr Tyr Ser Gly Tyr
 1               5                  10  


<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 10
Glu Asn Ile Tyr Ser Asn Leu
 1               5          


<210> 11
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 11
Ala Ala Lys
 1          


<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
Gln His Phe Trp Gly Thr Pro Trp Thr
 1               5                  


<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 13
Gly Phe Ala Phe Ser Ser Tyr Asp
 1               5              


<210> 14
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
Ile Thr Ile Gly Gly Gly Thr Thr
 1               5              


<210> 15
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
Ala Arg His Arg Tyr Asp Tyr Phe Ala Met Asp Asn
 1               5                  10          


<210> 16
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
Glu Asn Val Asp Asn Tyr Gly Ile Asn Phe
 1               5                  10  


<210> 17
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
Val Ser Ser
 1          


<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 18
Gln Gln Ser Lys Asp Val Pro Trp
 1               5              


<210> 19
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 19
Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly
 1               5                  10                  15      
Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser
            20                  25                  30          
Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp
        35                  40                  45              
Ile Gly Tyr Ile Asn Pro Thr Thr Gly Tyr Thr Asn Tyr Asn Gln Lys
    50                  55                  60                  
Phe Lys Asp Lys Ala Asn Pro Thr Thr Gly Tyr Thr Asn Tyr Asn Gln
65                  70                  75                  80  
Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr
                85                  90                  95      
Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr
            100                 105                 110         
Tyr Cys Ala Arg Asp Asp Ala Tyr Tyr Ser Gly Tyr Trp Gly Gln Gly
        115                 120                 125             
Thr Thr Leu Thr Val Ser Ser
    130                 135 


<210> 20
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 20
tcccaggtcc agctgcagca gtctggggct gaactggcaa gacctggggc ctcagtgaag 60
atgtcctgca aggcttctgg ctacaccttt actagttaca cgatgcactg ggtaaaacag 120
aggcctggac agggtctgga atggattgga tacattaatc ctactactgg ttatactaat 180
tacaatcaga agttcaagga caaggccaca ttgactgcag acaaatcctc cagcacagcc 240
tacatgcaat tgagcagcct gacatctgag gactctgcag tctattactg tgcaagagat 300
gatgcttact actcgggcta ctggggccaa ggcaccactc tcacagtctc ctca       354

<210> 21
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 21
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn
            20                  25                  30          
Leu Ala Trp Tyr Arg Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Ala Ala Lys Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105             


<210> 22
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 22
gacatccaga tgactcagtc tccagcctcc ctatctgtat ctgtgggaga aactgtcacc 60
atcacatgtc gagcaagtga gaatatttac agtaatttag catggtatcg gcagaaacag 120
ggaaaatctc ctcagctcct ggtctatgct gcaaaaaact tagcagatgg tgtgccatca 180
aggttcagtg gcagtggatc aggcacacag tattccctca agatcaacag cctgcagtct 240
gaagattttg ggagttatta ctgtcaacat ttttggggta ctccgtggac gttcggtgga 300
ggcaccaagc tggaaatcaa acgg                                        324

<210> 23
<211> 140
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser
 1               5                  10                  15      
Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr Asp
            20                  25                  30          
Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Val Trp Val Ala
        35                  40                  45              
Tyr Ile Thr Ile Gly Gly Gly Thr Thr Tyr Tyr Ser Asp Thr Val Lys
    50                  55                  60                  
Arg Leu Val Trp Val Ala Tyr Ile Thr Ile Gly Gly Gly Thr Thr Tyr
65                  70                  75                  80  
Tyr Ser Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr
            100                 105                 110         
Ala Met Tyr Tyr Cys Ala Arg His Arg Tyr Asp Tyr Phe Ala Met Asp
        115                 120                 125             
Asn Trp Gly His Gly Thr Ser Val Thr Val Ser Ser
    130                 135                 140 


<210> 24
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
gaagtgcagc tggtggagtc ggggggaggc ttagtgaagc ctggagggtc cctgaaactc 60
tcctgtgcag cctctggatt cgctttcagt agctatgaca tgtcttgggt tcgccagact 120
ccggagaaga ggctggtgtg ggtcgcatac attactattg gtggtggcac cacctactat 180
tcagacactg tgaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac 240
ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgc aagacatagg 300
tacgattact tcgctatgga caactggggt catggaacct cagtcaccgt ctcctca    357

<210> 25
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 25
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Glu
 1               5                  10                  15      
His Arg Ala Thr Ile Ser Cys Gln Ala Ser Glu Asn Val Asp Asn Tyr
            20                  25                  30          
Gly Ile Asn Phe Met Asn Trp Phe Gln His Lys Pro Ala Gln Pro Pro
        35                  40                  45              
Gln Leu Leu Ile Tyr Val Ser Ser Asn Leu Gly Ser Gly Val Pro Ala
    50                  55                  60                  
Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65                  70                  75                  80  
Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys
                85                  90                  95      
Asp Val Pro Trp Thr Phe Ser Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105                 110         


<210> 26
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 26
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagagca cagggccacc 60
atctcctgcc aagccagcga aaatgttgat aattatggca ttaattttat gaactggttc 120
caacacaaac cagcacagcc accccaactc ctcatctatg tttcatccaa cctaggatcc 180
ggggtccctg ccaagtttag tggcagtggg tctggaacag acttcagcct caacatccat 240
cctatggaag aagatgatac tgcaatgtat ttctgtcagc aaagtaagga cgttccgtgg 300
acgttcagtg gaggcaccaa actggaaatc aaacgg                           336

<210> 27
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 27
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Thr Met Ser Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
        35                  40                  45              
Ala Tyr Ile Ser His Gly Gly Gly Asp Thr Tyr Tyr Pro Asp Thr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Ser Gly Tyr Glu Arg Gly Tyr Tyr Tyr Val Met Asp Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120             


<210> 28
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 28
gaagtgaagt tggtggagtc tgggggaggt ttagtgcagc ctggagggtc cctgaaactc 60
tcctgtgcag cctctggatt cactttcagt agctatacca tgtcttggat tcgccagact 120
ccagagaaga ggctggagtg ggtcgcatac attagtcatg gtggtggtga cacctactat 180
ccagacactg taaagggccg attcaccatc tccagggaca atgccaagaa caccctgtac 240
ctgcaaatga gcagtctgaa gtctgaggac acggccatgt attactgtgc aagacatagt 300
ggttacgaga ggggatatta ctatgttatg gattactggg gtcaaggaac ctcagtcacc 360
gtctcctca                                                         369

<210> 29
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 29
Asp Ile Val Leu Thr Gln Phe Pro Thr Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Tyr
            20                  25                  30          
Gly Phe Ser Phe Ile Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala
    50                  55                  60                  
Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65                  70                  75                  80  
Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110     


<210> 30
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 30
gacattgtgc tgacccaatt tccaacttct ttggctgtgt ctctagggca gagggccacc 60
atctcctgca gagccagcga aagtgttgat tactatggct ttagttttat aaactggttc 120
caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccagggatcc 180
ggggtccctg ccaggtttgg tggcagtggg tctgggacag acttcagcct caacatccat 240
cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtgg 300
acgttcggtg gaggcaccaa gctggaaatc aaacgg                           336

<210> 31
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 31
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Thr Met Ser Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
        35                  40                  45              
Ala Tyr Ile Ser His Gly Gly Gly Asp Thr Tyr Tyr Pro Asp Thr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Ser Gly Tyr Glu Arg Gly Tyr Tyr Tyr Val Met Asp Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val
        195                 200                 205             
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys
    210                 215                 220                 
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu
            260                 265                 270         
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu
        435                 440                 445             
Gly Lys
    450 


<210> 32
<211> 1357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 32
cgaagtgaag ttggtggagt ctgggggagg tttagtgcag cctggagggt ccctgaaact 60
ctcctgtgca gcctctggat tcactttcag tagctatacc atgtcttgga ttcgccagac 120
tccagagaag aggctggagt gggtcgcata cattagtcat ggtggtggtg acacctacta 180
tccagacact gtaaagggcc gattcaccat ctccagggac aatgccaaga acaccctgta 240
cctgcaaatg agcagtctga agtctgagga cacggccatg tattactgtg caagacatag 300
tggttacgag aggggatatt actatgttat ggattactgg ggtcaaggaa cctcagtcac 360
cgtctcctca gctagcacca agggccccag cgtgtttcct ctcgctccct gcagccggag 420
cacatccgag agcaccgctg ctctgggctg tctcgtgaag gactacttcc ctgaacccgt 480
caccgtcagc tggaatagcg gcgccctgac atccggcgtc cacacattcc ccgctgtcct 540
gcagagcagc ggcctgtaca gcctgagctc cgtggtcacc gtgcctagca gcagcctggg 600
aacaaagacc tacacctgca acgtggacca taagccctcc aacaccaagg tggacaagcg 660
ggtggaatcc aagtatggac ccccctgtcc tccttgccct gctcctgaat ttctcggagg 720
cccctccgtc ttcctgtttc cccccaagcc caaggacacc ctgatgatct cccggacacc 780
cgaagtcacc tgcgtcgtgg tggatgtcag ccaggaagat cccgaggtgc agttcaactg 840
gtacgtggac ggagtggagg tgcataacgc caaaaccaag cccagggaag agcagttcaa 900
cagcacctat cgggtcgtgt ccgtgctcac cgtcctgcat caggattggc tcaacggcaa 960
ggagtacaag tgcaaggtgt ccaacaaggg cctgccctcc tccatcgaga agaccatctc 1020
caaggctaag ggccaacctc gggagcccca agtgtatacc ctccctccca gccaggagga 1080
gatgaccaag aatcaagtga gcctgacctg cctcgtgaag ggattttacc cctccgacat 1140
cgctgtggaa tgggaaagca atggccaacc tgagaacaac tacaagacca caccccccgt 1200
gctggactcc gatggctcct tcttcctgta cagcaggctg accgtggaca aatcccggtg 1260
gcaagaggga aacgtgttca gctgctccgt gatgcacgag gctctccaca accactacac 1320
ccagaagagc ctctccctga gcctcggcaa gtagtaa                          1357

<210> 33
<211> 219
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 33
Asp Ile Val Leu Thr Gln Phe Pro Thr Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Tyr
            20                  25                  30          
Gly Phe Ser Phe Ile Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala
    50                  55                  60                  
Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65                  70                  75                  80  
Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Gln Asp Ser Lys Asp Ser
                165                 170                 175     
Thr Tyr Ser Leu Thr Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 


<210> 34
<211> 661
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 34
agacattgtg ctgacccaat ttccaacttc tttggctgtg tctctagggc agagggccac 60
catctcctgc agagccagcg aaagtgttga ttactatggc tttagtttta taaactggtt 120
ccaacagaaa ccaggacagc cacccaaact cctcatctat gctgcatcca accagggatc 180
cggggtccct gccaggtttg gtggcagtgg gtctgggaca gacttcagcc tcaacatcca 240
tcctatggag gaggatgata ctgcaatgta tttctgtcag caaagtaagg aggttccgtg 300
gacgttcggt ggaggcacca agctggaaat caagcggacc gtggccgccc ccagcgtgtt 360
catcttccct cccagcgacg agcagctgaa gtctggcacc gccagcgtgg tgtgcctgct 420
gaacaacttc tacccccgcg aggccaaggt gcagtggaag gtggacaacg ccctgcagag 480
cggcaacagc caggagagcg tgaccgagca acaggactcc aaggacagca cctacagcct 540
gaccagcacc ctgaccctga gcaaggccga ctacgagaag cacaaggtgt acgcctgcga 600
ggtgacccac cagggactgt ctagccccgt gaccaagagc ttcaaccggg gcgagtgcta 660
a                                                                 661

<210> 35
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 35
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser His Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Ser Gly Tyr Glu Arg Gly Tyr Tyr Tyr Val Met Asp Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala
        115                 120                 


<210> 36
<211> 373
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 36
cgaagtgcag ctggtggaat ctggcggcgg actggtgcag cctggcggat ctctgagact 60
gtcttgtgcc gcctccggct tcaccttctc cagctacacc atgtcctggg tgcgacaggc 120
tcctggcaag ggcctggaat gggtgtccta catctctcac ggcggaggcg acacctacta 180
cgccgactct gtgaagggcc ggttcaccat ctcccgggac aactccaaga acaccctgta 240
cctgcagatg aactccctgc gggccgagga caccgccgtg tactactgtg ctcggcactc 300
tggctacgag cggggctact actacgtgat ggactactgg ggccagggca ccctcgtgac 360
cgtgtcatct gct                                                    373

<210> 37
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 37
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser His Gly Gly Gly Asp Thr Tyr Tyr Pro Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Ser Gly Tyr Glu Arg Gly Tyr Tyr Tyr Val Met Asp Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 38
<211> 373
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 38
cgaagtgcag ctggtggaat ctggcggcgg actggtgcag cctggcggat ctctgagact 60
gtcttgtgcc gcctccggct tcaccttctc cagctacacc atgtcctggg tgcgacaggc 120
tcctggcaag ggcctggaat gggtgtccta catctctcac ggcggaggcg acacctacta 180
ccccgactct gtgaagggcc ggttcaccat ctcccgggac aactccaaga acaccctgta 240
cctgcagatg aactccctgc gggccgagga caccgccgtg tactactgtg ctcggcactc 300
tggctacgag cggggctact actacgtgat ggactactgg ggccagggca ccctcgtgac 360
cgtgtcatct gct                                                    373

<210> 39
<211> 146
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 39
Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser His Gly Gly Gly Asp Thr Tyr Tyr Pro Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Gly Gly Asp Thr
65                  70                  75                  80  
Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Arg His Ser Gly Tyr Glu Arg Gly Tyr
        115                 120                 125             
Tyr Tyr Val Met Asp Tyr Trp Gly Lys Gly Thr Thr Val Thr Val Ser
    130                 135                 140                 
Ser Ala
145     


<210> 40
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 40
gaagtgaagc tgctggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg 60
tcttgtgccg cctccggctt caccttctcc agctacacca tgtcctgggt gcgacaggct 120
cctggcaagg gcctggaatg ggtgtcctac atctctcacg gcggaggcga cacctactac 180
cccgactctg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac 240
ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc tcggcactct 300
ggctacgagc ggggctacta ctacgtgatg gactactggg gcaagggcac caccgtgacc 360
gtgtcatctg ct                                                     372

<210> 41
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 41
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Asp Tyr Tyr
            20                  25                  30          
Gly Phe Ser Phe Leu Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Arg Glu Ser Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105                 110         


<210> 42
<211> 337
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 42
agacatcgtg atgacccagt cccccgactc cctggctgtg tctctgggcg agagagccac 60
catcaactgc aagtcctccg agtccgtgga ctactacggc ttctccttcc tgaactggtt 120
ccagcagaag cccggccagc cccctaagct gctgatctac gccgcctcca accgcgagtc 180
tggcgtgccc gatagattct ccggctctgg ctctggcacc gactttaccc tgaccatcag 240
ctccctgcag gccgaggatg tggccgtgta ctactgccag cagtccaaag aggtgccctg 300
gaccttcggc cagggcacaa agctggaaat caagcgg                          337

<210> 43
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 43
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Glu Ser Val Asp Tyr Tyr
            20                  25                  30          
Gly Phe Ser Phe Leu Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Arg Glu Ser Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105                 110         


<210> 44
<211> 337
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 44
agacatcgtg atgacccagt cccccgactc cctggctgtg tctctgggcg agagagccac 60
catcaactgc aaggcctccg agtccgtgga ctactacggc ttctccttcc tgaactggtt 120
ccagcagaag cccggccagc cccctaagct gctgatctac gccgcctcca accgcgagtc 180
tggcgtgccc gatagattct ccggctctgg ctctggcacc gactttaccc tgaccatcag 240
ctccctgcag gccgaggatg tggccgtgta ctactgccag cagtccaaag aggtgccctg 300
gaccttcggc cagggcacaa agctggaaat caagcgg                          337

<210> 45
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 45
Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ser Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Glu Ser Val Asp Tyr Tyr
            20                  25                  30          
Gly Phe Ser Phe Leu Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Arg Gln Ser Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln Gln Ser Lys
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105                 110         


<210> 46
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 46
gacatccagc tgacccagtc ccccgactcc ctgtctgtgt ctctgggcga gagagccacc 60
atcaactgca aggcctccga gtccgtggac tactacggct tctccttcct gaactggttc 120
cagcagaagc ccggccagcc ccctaagctg ctgatctacg ccgcctccaa ccgccagtct 180
ggcgtgcccg atagattctc cggctctggc tctggcaccg actttaccct gaccatcagc 240
tccctgcagg ccgaggatgt ggccgtgtac ttctgccagc agtccaaaga ggtgccctgg 300
accttcggcc agggcacaaa gctggaaatc aagcgg                           336

<210> 47
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 47
ctgtctagaa tgcagatccc acaggcgcc                                   29

<210> 48
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 48
ggatcctcag aggggccaag agcagt                                      26

<210> 49
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 49
Ser Tyr Thr Met Ser
 1               5  


<210> 50
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 50
Tyr Ile Ser His Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 51
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 51
His Ser Gly Tyr Glu Arg Gly Tyr Tyr Tyr Val Met Asp Tyr
 1               5                  10                  


<210> 52
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 52
Lys Ser Ser Glu Ser Val Asp Tyr Tyr Gly Phe Ser Phe Leu Asn
 1               5                  10                  15  


<210> 53
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 53
Ala Ala Ser Asn Arg Glu Ser
 1               5          


<210> 54
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 54
Gln Gln Ser Lys Glu Val Pro Trp Thr
 1               5                  


<210> 55
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 55
Tyr Ile Ser His Gly Gly Gly Asp Thr Tyr Tyr Pro Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 56
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 56
Lys Ala Ser Glu Ser Val Asp Tyr Tyr Gly Phe Ser Phe Leu Asn
 1               5                  10                  15  


<210> 57
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 57
Ala Ala Ser Asn Arg Gln Ser
 1               5          


<210> 58
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 58
Gly Phe Thr Phe Ser Ser Tyr
 1               5          


<210> 59
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 59
Ser His Gly Gly Gly Asp
 1               5      


<210> 60
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 60
Gly Phe Thr Phe Ser Ser Tyr Thr Met Ser
 1               5                  10  


<210> 61
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 61
Tyr Ile Ser His Gly Gly Gly Asp Thr Tyr
 1               5                  10  


<210> 62
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 62
Ser Ser Tyr Thr Met Ser
 1               5      


<210> 63
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 63
Trp Val Ser Tyr Ile Ser His Gly Gly Gly Asp Thr Tyr
 1               5                  10              


<210> 64
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 64
Ala Arg His Ser Gly Tyr Glu Arg Gly Tyr Tyr Tyr Val Met Asp
 1               5                  10                  15  


<210> 65
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 65
Asp Tyr Tyr Gly Phe Ser Phe Leu Asn Trp Phe
 1               5                  10      


<210> 66
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 66
Leu Leu Ile Tyr Ala Ala Ser Asn Arg Glu
 1               5                  10  


<210> 67
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 67
Leu Leu Ile Tyr Ala Ala Ser Asn Arg Gln
 1               5                  10  

