                               SEQUENCE LISTING

<110> UNIVERSITY OF GEORGIA RESEARCH FOUNDATION
 
<120> BROADLY REACTIVE IMMUNOGENS OF DENGUE VIRUS, COMPOSITIONS, AND 
      METHODS OF USE THEREOF

<130> 173093.010601/PCT

<140> PCT/US2019/041683
<141> 2019-07-12

<150> 62/697,851
<151> 2018-07-13

<160> 11    

<170> PatentIn version 3.5

<210> 1
<211> 495
<212> PRT
<213> Dengue virus

<400> 1
Met Arg Cys Val Gly Ile Gly Ser Arg Asp Phe Val Glu Gly Leu Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asp Lys Pro Thr Leu Asp Ile Glu Leu Leu Lys Thr 
        35                  40                  45              


Glu Val Thr Asn Pro Ala Val Leu Arg Lys Leu Cys Ile Glu Ala Lys 
    50                  55                  60                  


Ile Ser Asn Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Thr Leu Val Glu Glu Gln Asp Ala Asn Phe Val Cys Arg Arg Thr Phe 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Ile Thr Cys Ala Lys Phe Lys Cys Val Thr Lys Leu Glu Gly Lys 
        115                 120                 125             


Ile Val Gln Tyr Glu Asn Leu Lys Tyr Ser Val Ile Val Thr Val His 
    130                 135                 140                 


Thr Gly Asp Gln His Gln Val Gly Asn Glu Ser Thr Glu His Gly Thr 
145                 150                 155                 160 


Thr Ala Thr Ile Thr Pro Gln Ala Pro Thr Ser Glu Ile Gln Leu Thr 
                165                 170                 175     


Asp Tyr Gly Ala Leu Thr Leu Asp Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Thr Met Lys Glu Lys Ser Trp Leu Val 
        195                 200                 205             


His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala 
    210                 215                 220                 


Ser Thr Ser Gln Glu Thr Trp Asn Arg Gln Asp Leu Leu Val Thr Phe 
225                 230                 235                 240 


Lys Thr Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr 
            260                 265                 270         


Ser Gly Thr Thr Thr Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys 
        275                 280                 285             


Met Asp Lys Leu Thr Leu Lys Gly Met Ser Tyr Val Met Cys Thr Gly 
    290                 295                 300                 


Ser Phe Lys Leu Glu Lys Glu Val Ala Glu Thr Gln His Gly Thr Val 
305                 310                 315                 320 


Leu Val Gln Ile Lys Tyr Glu Gly Thr Asp Ala Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Ser Thr Gln Asp Glu Lys Gly Val Thr Gln Asn Gly Arg Leu Ile 
            340                 345                 350         


Thr Ala Asn Pro Ile Val Thr Asp Lys Glu Lys Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Glu Ser Tyr Ile Val Ile Gly Ala Gly Glu 
    370                 375                 380                 


Lys Ala Leu Lys Leu Ser Trp Phe Lys Lys Gly Ser Ser Ile Gly Lys 
385                 390                 395                 400 


Met Phe Glu Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Thr Ser Val 
            420                 425                 430         


Gly Lys Leu Val His Gln Ile Phe Gly Thr Ala Tyr Gly Val Leu Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Gly Ile Gly Val Leu Leu Thr 
    450                 455                 460                 


Trp Leu Gly Leu Asn Ser Arg Ser Thr Ser Leu Ser Met Thr Cys Ile 
465                 470                 475                 480 


Ala Val Gly Leu Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala 
                485                 490                 495 


<210> 2
<211> 495
<212> PRT
<213> Dengue virus

<400> 2
Met Arg Cys Val Gly Ile Gly Asn Arg Asp Phe Val Glu Gly Leu Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Leu Lys Thr 
        35                  40                  45              


Glu Val Thr Asn Pro Ala Ile Leu Arg Lys Leu Cys Ile Glu Ala Lys 
    50                  55                  60                  


Ile Ser Asn Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Thr Leu Val Glu Glu Gln Asp Ala Asn Phe Val Cys Arg Arg Thr Phe 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Leu Thr Cys Ala Lys Phe Lys Cys Val Thr Lys Leu Glu Gly Lys 
        115                 120                 125             


Ile Val Gln Tyr Glu Asn Leu Lys Tyr Ser Val Ile Val Thr Val His 
    130                 135                 140                 


Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Thr Glu His Gly Thr 
145                 150                 155                 160 


Ile Ala Thr Ile Thr Pro Gln Ala Pro Thr Ser Glu Ile Gln Leu Thr 
                165                 170                 175     


Asp Tyr Gly Ala Leu Thr Leu Asp Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Thr Met Lys Glu Lys Ser Trp Leu Val 
        195                 200                 205             


His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala 
    210                 215                 220                 


Ser Thr Ser Gln Glu Thr Trp Asn Arg Gln Asp Leu Leu Val Thr Phe 
225                 230                 235                 240 


Lys Thr Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr 
            260                 265                 270         


Ser Gly Thr Thr Thr Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys 
        275                 280                 285             


Met Asp Lys Leu Thr Leu Lys Gly Thr Ser Tyr Val Met Cys Thr Gly 
    290                 295                 300                 


Ser Phe Lys Leu Glu Lys Glu Val Ala Glu Thr Gln His Gly Thr Val 
305                 310                 315                 320 


Leu Val Gln Val Lys Tyr Glu Gly Thr Asp Ala Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Ser Thr Gln Asp Glu Lys Gly Val Thr Gln Asn Gly Arg Leu Ile 
            340                 345                 350         


Thr Ala Asn Pro Ile Val Thr Asp Lys Glu Lys Pro Val Asn Ile Glu 
        355                 360                 365             


Thr Glu Pro Pro Phe Gly Glu Ser Tyr Ile Val Val Gly Ala Gly Glu 
    370                 375                 380                 


Lys Ala Leu Lys Leu Ser Trp Phe Lys Lys Gly Ser Ser Ile Gly Lys 
385                 390                 395                 400 


Met Phe Glu Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Thr Ser Val 
            420                 425                 430         


Gly Lys Leu Val His Gln Val Phe Gly Thr Ala Tyr Gly Val Leu Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Gly Ile Gly Ile Leu Leu Thr 
    450                 455                 460                 


Trp Leu Gly Leu Asn Ser Arg Ser Thr Ser Leu Ser Met Thr Cys Ile 
465                 470                 475                 480 


Ala Val Gly Met Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala 
                485                 490                 495 


<210> 3
<211> 495
<212> PRT
<213> Dengue virus

<400> 3
Met Arg Cys Ile Gly Ile Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Ile Val Thr Cys Ala Met Phe Thr Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             


Ile Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His 
    130                 135                 140                 


Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 


Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     


Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Gln Met Glu Asp Lys Ala Trp Leu Val 
        195                 200                 205             


His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 


Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 


Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         


Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             


Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 


Lys Phe Lys Ile Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 


Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         


Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 


Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly Ser Ser Ile Gly Gln 
385                 390                 395                 400 


Met Phe Glu Thr Thr Met Arg Gly Ala Lys Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr Ser Ile 
            420                 425                 430         


Gly Lys Ala Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala Ala Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Leu Ile Gly Val Ile Ile Thr 
    450                 455                 460                 


Trp Ile Gly Met Asn Ser Arg Ser Thr Ser Leu Ser Val Ser Leu Val 
465                 470                 475                 480 


Leu Val Gly Val Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala 
                485                 490                 495 


<210> 4
<211> 493
<212> PRT
<213> Dengue virus

<400> 4
Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Leu Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Gln Lys Thr 
        35                  40                  45              


Glu Ala Thr Gln Leu Ala Thr Leu Arg Lys Leu Cys Ile Glu Gly Lys 
    50                  55                  60                  


Ile Thr Asn Ile Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Thr Leu Pro Glu Glu Gln Asp Gln Asn Tyr Val Cys Lys His Thr Tyr 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Gln Cys Leu Glu Pro Ile Glu Gly Lys 
        115                 120                 125             


Val Val Gln Tyr Glu Asn Leu Lys Tyr Thr Val Ile Ile Thr Val His 
    130                 135                 140                 


Thr Gly Asp Gln His Gln Val Gly Asn Asp Thr Gln Gly Val Thr Val 
145                 150                 155                 160 


Glu Ile Thr Pro Gln Ala Ser Thr Val Glu Ala Ile Leu Pro Glu Tyr 
                165                 170                 175     


Gly Thr Leu Gly Leu Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn 
            180                 185                 190         


Glu Met Ile Leu Leu Thr Met Lys Asn Lys Ala Trp Met Val His Arg 
        195                 200                 205             


Gln Trp Phe Phe Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala Thr Thr 
    210                 215                 220                 


Glu Thr Pro Thr Trp Asn Arg Lys Glu Leu Leu Val Thr Phe Lys Asn 
225                 230                 235                 240 


Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln Glu Gly 
                245                 250                 255     


Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Asn Ser Gly 
            260                 265                 270         


Gly Thr Ser Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys Met Asp 
        275                 280                 285             


Lys Leu Glu Leu Lys Gly Met Ser Tyr Ala Met Cys Leu Asn Thr Phe 
    290                 295                 300                 


Val Leu Lys Lys Glu Val Ser Glu Thr Gln His Gly Thr Ile Leu Ile 
305                 310                 315                 320 


Lys Val Glu Tyr Lys Gly Glu Asp Ala Pro Cys Lys Ile Pro Phe Ser 
                325                 330                 335     


Thr Glu Asp Gly Gln Gly Lys Ala His Asn Gly Arg Leu Ile Thr Ala 
            340                 345                 350         


Asn Pro Val Val Thr Lys Lys Glu Glu Pro Val Asn Ile Glu Ala Glu 
        355                 360                 365             


Pro Pro Phe Gly Glu Ser Asn Ile Val Ile Gly Ile Gly Asp Lys Ala 
    370                 375                 380                 


Leu Lys Ile Asn Trp Tyr Lys Lys Gly Ser Ser Ile Gly Lys Met Phe 
385                 390                 395                 400 


Glu Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly Asp Thr 
                405                 410                 415     


Ala Trp Asp Phe Gly Ser Val Gly Gly Val Leu Asn Ser Leu Gly Lys 
            420                 425                 430         


Met Val His Gln Ile Phe Gly Ser Ala Tyr Thr Ala Leu Phe Ser Gly 
        435                 440                 445             


Val Ser Trp Ile Met Lys Ile Gly Ile Gly Val Leu Leu Thr Trp Ile 
    450                 455                 460                 


Gly Leu Asn Ser Lys Asn Thr Ser Met Ser Phe Ser Cys Ile Ala Ile 
465                 470                 475                 480 


Gly Ile Ile Thr Leu Tyr Leu Gly Ala Val Val Gln Ala 
                485                 490             


<210> 5
<211> 493
<212> PRT
<213> Dengue virus

<400> 5
Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Leu Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Gln Lys Thr 
        35                  40                  45              


Glu Ala Thr Gln Leu Ala Thr Leu Arg Lys Leu Cys Ile Glu Gly Lys 
    50                  55                  60                  


Ile Thr Asn Ile Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Val Leu Pro Glu Glu Gln Asp Gln Asn Tyr Val Cys Lys His Thr Tyr 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Gln Cys Leu Glu Pro Ile Glu Gly Lys 
        115                 120                 125             


Val Val Gln Tyr Glu Asn Leu Lys Tyr Thr Val Ile Ile Thr Val His 
    130                 135                 140                 


Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Gln Gly Val Thr Ala 
145                 150                 155                 160 


Glu Ile Thr Pro Gln Ala Ser Thr Thr Glu Ala Ile Leu Pro Glu Tyr 
                165                 170                 175     


Gly Thr Leu Gly Leu Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn 
            180                 185                 190         


Glu Met Ile Leu Leu Thr Met Lys Asn Lys Ala Trp Met Val His Arg 
        195                 200                 205             


Gln Trp Phe Phe Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala Thr Thr 
    210                 215                 220                 


Glu Thr Pro Thr Trp Asn Arg Lys Glu Leu Leu Val Thr Phe Lys Asn 
225                 230                 235                 240 


Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln Glu Gly 
                245                 250                 255     


Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Asn Ser Gly 
            260                 265                 270         


Gly Thr Ser Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys Met Asp 
        275                 280                 285             


Lys Leu Glu Leu Lys Gly Met Ser Tyr Ala Met Cys Thr Asn Thr Phe 
    290                 295                 300                 


Val Leu Lys Lys Glu Val Ser Glu Thr Gln His Gly Thr Ile Leu Ile 
305                 310                 315                 320 


Lys Val Glu Tyr Lys Gly Glu Asp Val Pro Cys Lys Ile Pro Phe Ser 
                325                 330                 335     


Thr Glu Asp Gly Gln Gly Lys Ala His Asn Gly Arg Leu Ile Thr Ala 
            340                 345                 350         


Asn Pro Val Val Thr Lys Lys Glu Glu Pro Val Asn Ile Glu Ala Glu 
        355                 360                 365             


Pro Pro Phe Gly Glu Ser Asn Ile Val Ile Gly Ile Gly Asp Asn Ala 
    370                 375                 380                 


Leu Lys Ile Asn Trp Tyr Lys Lys Gly Ser Ser Ile Gly Lys Met Phe 
385                 390                 395                 400 


Glu Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly Asp Thr 
                405                 410                 415     


Ala Trp Asp Phe Gly Ser Val Gly Gly Val Leu Asn Ser Leu Gly Lys 
            420                 425                 430         


Met Val His Gln Ile Phe Gly Ser Ala Tyr Thr Ala Leu Phe Ser Gly 
        435                 440                 445             


Val Ser Trp Val Met Lys Ile Gly Ile Gly Val Leu Leu Thr Trp Ile 
    450                 455                 460                 


Gly Leu Asn Ser Lys Asn Thr Ser Met Ser Phe Ser Cys Ile Ala Ile 
465                 470                 475                 480 


Gly Ile Ile Thr Leu Tyr Leu Gly Ala Val Val Gln Ala 
                485                 490             


<210> 6
<211> 495
<212> PRT
<213> Dengue virus

<400> 6
Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ala Trp Val Asp Leu Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Thr Met Ala Gln Gly Lys Pro Thr Leu Asp Phe Glu Leu Thr Lys Thr 
        35                  40                  45              


Thr Ala Lys Glu Val Ala Leu Leu Arg Thr Tyr Cys Ile Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asn Ile Thr Thr Ala Thr Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Tyr Leu Lys Glu Glu Gln Asp Gln Gln Tyr Ile Cys Arg Arg Asp Val 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Val Val Thr Cys Ala Lys Phe Ser Cys Ser Gly Lys Ile Thr Gly Asn 
        115                 120                 125             


Leu Val Gln Ile Glu Asn Leu Glu Tyr Thr Val Val Val Thr Val His 
    130                 135                 140                 


Asn Gly Asp Thr His Ala Val Gly Asn Asp Thr Ser Asn His Gly Val 
145                 150                 155                 160 


Thr Ala Thr Ile Thr Pro Arg Ser Pro Ser Val Glu Val Lys Leu Pro 
                165                 170                 175     


Asp Tyr Gly Glu Leu Thr Leu Asp Cys Glu Pro Arg Ser Gly Ile Asp 
            180                 185                 190         


Phe Asn Glu Met Ile Leu Met Lys Met Lys Lys Lys Thr Trp Leu Val 
        195                 200                 205             


His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ala Gly Ala 
    210                 215                 220                 


Asp Thr Ser Glu Val His Trp Asn Tyr Lys Glu Arg Met Val Thr Phe 
225                 230                 235                 240 


Lys Val Pro His Ala Lys Arg Gln Asp Val Thr Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Ser Ala Leu Ala Gly Ala Thr Glu Val Asp Ser 
            260                 265                 270         


Gly Asp Gly Asn His Met Phe Ala Gly His Leu Lys Cys Lys Val Arg 
        275                 280                 285             


Met Glu Lys Leu Arg Ile Lys Gly Met Ser Tyr Thr Met Cys Ser Gly 
    290                 295                 300                 


Lys Phe Ser Ile Asp Lys Glu Met Ala Glu Thr Gln His Gly Thr Thr 
305                 310                 315                 320 


Val Val Lys Val Lys Tyr Glu Gly Ala Gly Ala Pro Cys Lys Val Pro 
                325                 330                 335     


Ile Glu Ile Arg Asp Val Asn Lys Glu Lys Val Val Gly Arg Ile Ile 
            340                 345                 350         


Ser Ser Thr Pro Phe Ala Glu Asn Thr Asn Ser Val Thr Asn Ile Glu 
        355                 360                 365             


Leu Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp 
    370                 375                 380                 


Ser Ala Leu Thr Leu His Trp Phe Arg Lys Gly Ser Ser Ile Gly Lys 
385                 390                 395                 400 


Met Phe Glu Ser Thr Tyr Arg Gly Ala Lys Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Glu Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Leu Phe Thr Ser Leu 
            420                 425                 430         


Gly Lys Ala Val His Gln Val Phe Gly Ser Val Tyr Thr Thr Met Phe 
        435                 440                 445             


Gly Gly Val Ser Trp Met Ile Arg Ile Leu Ile Gly Phe Leu Val Leu 
    450                 455                 460                 


Trp Ile Gly Thr Asn Ser Arg Asn Thr Ser Met Ala Met Thr Cys Ile 
465                 470                 475                 480 


Ala Val Gly Gly Ile Thr Leu Phe Leu Gly Phe Thr Val Gln Ala 
                485                 490                 495 


<210> 7
<211> 495
<212> PRT
<213> Dengue virus

<400> 7
Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ala Trp Val Asp Leu Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Thr Met Ala Gln Gly Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Thr Ala Lys Glu Val Ala Leu Leu Arg Thr Tyr Cys Ile Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asn Ile Thr Thr Ala Thr Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Tyr Leu Lys Glu Glu Gln Asp Gln Gln Tyr Ile Cys Arg Arg Asp Met 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Val Val Thr Cys Ala Lys Phe Ser Cys Ser Gly Lys Ile Thr Gly Asn 
        115                 120                 125             


Leu Val Gln Ile Glu Asn Leu Glu Tyr Thr Val Val Val Thr Val His 
    130                 135                 140                 


Asn Gly Asp Thr His Ala Val Gly Asn Asp Thr Ser Asn His Gly Val 
145                 150                 155                 160 


Thr Ala Thr Ile Thr Pro Arg Ser Pro Ser Val Glu Val Lys Leu Pro 
                165                 170                 175     


Asp Tyr Gly Glu Leu Thr Leu Asp Cys Glu Pro Arg Ser Gly Ile Asp 
            180                 185                 190         


Phe Asn Glu Met Ile Leu Met Lys Met Lys Thr Lys Thr Trp Leu Val 
        195                 200                 205             


His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ala Gly Ala 
    210                 215                 220                 


Asp Thr Ser Glu Val His Trp Asn His Lys Glu Arg Met Val Thr Phe 
225                 230                 235                 240 


Lys Val Pro His Ala Lys Arg Gln Asp Val Thr Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Ser Ala Leu Ala Gly Ala Thr Glu Val Asp Ser 
            260                 265                 270         


Gly Asp Gly Asn His Met Phe Ala Gly His Leu Lys Cys Lys Val Arg 
        275                 280                 285             


Met Glu Lys Leu Arg Ile Lys Gly Met Ser Tyr Thr Met Cys Ser Gly 
    290                 295                 300                 


Lys Phe Ser Ile Asp Lys Glu Met Ala Glu Thr Gln His Gly Thr Thr 
305                 310                 315                 320 


Val Val Lys Val Lys Tyr Glu Gly Thr Gly Ala Pro Cys Lys Val Pro 
                325                 330                 335     


Ile Glu Ile Arg Asp Val Asn Lys Glu Lys Val Val Gly Arg Ile Ile 
            340                 345                 350         


Ser Ser Thr Pro Phe Ala Glu Asn Thr Asn Ser Val Thr Asn Ile Glu 
        355                 360                 365             


Leu Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp 
    370                 375                 380                 


Ser Ala Leu Thr Leu His Trp Phe Arg Lys Gly Ser Ser Ile Gly Lys 
385                 390                 395                 400 


Met Phe Glu Ser Thr Tyr Arg Gly Ala Lys Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Glu Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Leu Leu Thr Ser Leu 
            420                 425                 430         


Gly Lys Ala Val His Gln Val Phe Gly Ser Val Tyr Thr Thr Met Phe 
        435                 440                 445             


Gly Gly Val Ser Trp Met Val Arg Ile Leu Ile Gly Leu Leu Val Leu 
    450                 455                 460                 


Trp Ile Gly Thr Asn Ser Arg Asn Thr Ser Met Ala Met Ser Cys Ile 
465                 470                 475                 480 


Ala Val Gly Gly Ile Thr Leu Phe Leu Gly Phe Thr Val His Ala 
                485                 490                 495 


<210> 8
<211> 662
<212> PRT
<213> Dengue virus

<400> 8
Ala Phe His Leu Thr Thr Arg Gly Gly Glu Pro His Met Ile Val Ser 
1               5                   10                  15      


Lys Gln Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ser Ala Gly Val 
            20                  25                  30          


Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Leu Cys Glu Asp 
        35                  40                  45              


Thr Met Thr Tyr Lys Cys Pro Arg Ile Thr Glu Ala Glu Pro Asp Asp 
    50                  55                  60                  


Val Asp Cys Trp Cys Asn Ala Thr Asp Thr Trp Val Thr Tyr Gly Thr 
65                  70                  75                  80  


Cys Ser Gln Thr Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala Leu 
                85                  90                  95      


Ala Pro His Val Gly Leu Gly Leu Glu Thr Arg Ala Glu Thr Trp Met 
            100                 105                 110         


Ser Ser Glu Gly Ala Trp Lys Gln Ile Gln Lys Val Glu Thr Trp Ala 
        115                 120                 125             


Leu Arg His Pro Gly Phe Thr Val Ile Ala Leu Phe Leu Ala His Ala 
    130                 135                 140                 


Ile Gly Thr Ser Ile Thr Gln Lys Gly Ile Ile Phe Ile Leu Leu Met 
145                 150                 155                 160 


Leu Val Thr Pro Ser Met Ala Met Arg Cys Val Gly Ile Gly Asn Arg 
                165                 170                 175     


Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val Leu 
            180                 185                 190         


Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu 
        195                 200                 205             


Asp Ile Glu Leu Leu Lys Thr Glu Val Thr Asn Pro Ala Val Leu Arg 
    210                 215                 220                 


Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser Arg 
225                 230                 235                 240 


Cys Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Ala Asn 
                245                 250                 255     


Phe Val Cys Arg Arg Thr Phe Val Asp Arg Gly Trp Gly Asn Gly Cys 
            260                 265                 270         


Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys Cys 
        275                 280                 285             


Val Thr Lys Leu Glu Gly Lys Ile Val Gln Tyr Glu Asn Leu Lys Tyr 
    290                 295                 300                 


Ser Val Ile Val Thr Val His Thr Gly Asp Gln His Gln Val Gly Asn 
305                 310                 315                 320 


Glu Thr Thr Glu His Gly Thr Thr Ala Thr Ile Thr Pro Gln Ala Pro 
                325                 330                 335     


Thr Ser Glu Ile Gln Leu Thr Asp Tyr Gly Ala Leu Thr Leu Asp Cys 
            340                 345                 350         


Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Thr Met 
        355                 360                 365             


Lys Glu Lys Ser Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu Pro 
    370                 375                 380                 


Leu Pro Trp Thr Ser Gly Ala Ser Thr Ser Gln Glu Thr Trp Asn Arg 
385                 390                 395                 400 


Gln Asp Leu Leu Val Thr Phe Lys Thr Ala His Ala Lys Lys Gln Glu 
                405                 410                 415     


Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr 
            420                 425                 430         


Gly Ala Thr Glu Ile Gln Thr Ser Gly Thr Thr Thr Ile Phe Ala Gly 
        435                 440                 445             


His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Thr Leu Lys Gly Met 
    450                 455                 460                 


Ser Tyr Val Met Cys Thr Gly Ser Phe Lys Leu Glu Lys Glu Val Ala 
465                 470                 475                 480 


Glu Thr Gln His Gly Thr Val Leu Val Gln Val Lys Tyr Glu Gly Thr 
                485                 490                 495     


Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr Gln Asp Glu Lys Gly Val 
            500                 505                 510         


Thr Gln Asn Gly Arg Leu Ile Thr Ala Asn Pro Ile Val Thr Asp Lys 
        515                 520                 525             


Glu Lys Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser Tyr 
    530                 535                 540                 


Ile Val Val Gly Ala Gly Glu Lys Ala Leu Lys Leu Ser Trp Phe Lys 
545                 550                 555                 560 


Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly Ala 
                565                 570                 575     


Arg Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile 
            580                 585                 590         


Gly Gly Val Phe Thr Ser Val Gly Lys Leu Val His Gln Ile Phe Gly 
        595                 600                 605             


Thr Ala Tyr Gly Val Leu Phe Ser Gly Val Ser Trp Thr Met Lys Ile 
    610                 615                 620                 


Gly Ile Gly Ile Leu Leu Thr Trp Leu Gly Leu Asn Ser Arg Ser Thr 
625                 630                 635                 640 


Ser Leu Ser Met Thr Cys Ile Ala Val Gly Met Val Thr Leu Tyr Leu 
                645                 650                 655     


Gly Val Met Val Gln Ala 
            660         


<210> 9
<211> 662
<212> PRT
<213> Dengue virus

<400> 9
Met Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val Ser 
1               5                   10                  15      


Arg Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp Gly Val 
            20                  25                  30          


Asn Met Cys Thr Leu Met Ala Met Asp Leu Gly Glu Leu Cys Glu Asp 
        35                  40                  45              


Thr Ile Thr Tyr Lys Cys Pro Phe Leu Lys Gln Asn Glu Pro Glu Asp 
    50                  55                  60                  


Ile Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly Thr 
65                  70                  75                  80  


Cys Thr Thr Thr Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala Leu 
                85                  90                  95      


Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp Met 
            100                 105                 110         


Ser Ser Glu Gly Ala Trp Lys His Ala Gln Arg Ile Glu Thr Trp Ile 
        115                 120                 125             


Leu Arg His Pro Gly Phe Thr Ile Met Ala Ala Ile Leu Ala Tyr Thr 
    130                 135                 140                 


Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu Thr 
145                 150                 155                 160 


Ala Val Ala Pro Ser Met Thr Met Arg Cys Ile Gly Ile Ser Asn Arg 
                165                 170                 175     


Asp Phe Val Glu Gly Val Ser Gly Gly Ser Trp Val Asp Ile Val Leu 
            180                 185                 190         


Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu 
        195                 200                 205             


Asp Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu Arg 
    210                 215                 220                 


Lys Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser Arg 
225                 230                 235                 240 


Cys Pro Thr Gln Gly Glu Pro Ser Leu Asn Glu Glu Gln Asp Lys Arg 
                245                 250                 255     


Phe Val Cys Lys His Ser Met Val Asp Arg Gly Trp Gly Asn Gly Cys 
            260                 265                 270         


Gly Leu Phe Gly Lys Gly Gly Ile Val Thr Cys Ala Met Phe Thr Cys 
        275                 280                 285             


Lys Lys Asn Met Glu Gly Lys Ile Val Gln Pro Glu Asn Leu Glu Tyr 
    290                 295                 300                 


Thr Ile Val Ile Thr Pro His Ser Gly Glu Glu His Ala Val Gly Asn 
305                 310                 315                 320 


Asp Thr Gly Lys His Gly Lys Glu Ile Lys Ile Thr Pro Gln Ser Ser 
                325                 330                 335     


Ile Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met Glu Cys 
            340                 345                 350         


Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Gln Met 
        355                 360                 365             


Glu Asn Lys Ala Trp Leu Val His Arg Gln Trp Phe Leu Asp Leu Pro 
    370                 375                 380                 


Leu Pro Trp Leu Pro Gly Ala Asp Thr Gln Gly Ser Asn Trp Ile Gln 
385                 390                 395                 400 


Lys Glu Thr Leu Val Thr Phe Lys Asn Pro His Ala Lys Lys Gln Asp 
                405                 410                 415     


Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr 
            420                 425                 430         


Gly Ala Thr Glu Ile Gln Met Ser Ser Gly Asn Leu Leu Phe Thr Gly 
        435                 440                 445             


His Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys Gly Met 
    450                 455                 460                 


Ser Tyr Ser Met Cys Thr Gly Lys Phe Lys Val Val Lys Glu Ile Ala 
465                 470                 475                 480 


Glu Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp 
                485                 490                 495     


Gly Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg 
            500                 505                 510         


His Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys 
        515                 520                 525             


Asp Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr 
    530                 535                 540                 


Ile Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe Lys 
545                 550                 555                 560 


Lys Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly Ala 
                565                 570                 575     


Lys Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Leu 
            580                 585                 590         


Gly Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe Gly 
        595                 600                 605             


Ala Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr Met Lys Ile 
    610                 615                 620                 


Leu Ile Gly Val Ile Ile Thr Trp Ile Gly Met Asn Ser Arg Ser Thr 
625                 630                 635                 640 


Ser Leu Ser Val Ser Leu Val Leu Val Gly Ile Val Thr Leu Tyr Leu 
                645                 650                 655     


Gly Val Met Val Gln Ala 
            660         


<210> 10
<211> 660
<212> PRT
<213> Dengue virus

<400> 10
Met Phe His Leu Thr Ser Arg Asp Gly Glu Pro Arg Met Ile Val Gly 
1               5                   10                  15      


Lys Asn Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ala Ser Gly Ile 
            20                  25                  30          


Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys Asp Asp 
        35                  40                  45              


Thr Val Thr Tyr Lys Cys Pro His Ile Thr Glu Val Glu Pro Glu Asp 
    50                  55                  60                  


Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Thr Tyr Gly Thr 
65                  70                  75                  80  


Cys Asn Gln Ala Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala Leu 
                85                  90                  95      


Ala Pro His Val Gly Met Gly Leu Asp Thr Arg Thr Gln Thr Trp Met 
            100                 105                 110         


Ser Ala Glu Gly Ala Trp Arg Gln Val Glu Lys Val Glu Thr Trp Ala 
        115                 120                 125             


Leu Arg His Pro Gly Phe Thr Ile Leu Ala Leu Phe Leu Ala His Tyr 
    130                 135                 140                 


Ile Gly Thr Ser Leu Thr Gln Lys Val Val Ile Phe Ile Leu Leu Met 
145                 150                 155                 160 


Leu Val Thr Pro Ser Met Thr Met Arg Cys Val Gly Val Gly Asn Arg 
                165                 170                 175     


Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val Leu 
            180                 185                 190         


Glu His Gly Gly Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu 
        195                 200                 205             


Asp Ile Glu Leu Gln Lys Thr Glu Ala Thr Gln Leu Ala Thr Leu Arg 
    210                 215                 220                 


Lys Leu Cys Ile Glu Gly Lys Ile Thr Asn Ile Thr Thr Asp Ser Arg 
225                 230                 235                 240 


Cys Pro Thr Gln Gly Glu Ala Ile Leu Pro Glu Glu Gln Asp Gln Asn 
                245                 250                 255     


Tyr Val Cys Lys His Thr Tyr Val Asp Arg Gly Trp Gly Asn Gly Cys 
            260                 265                 270         


Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Gln Cys 
        275                 280                 285             


Leu Glu Pro Ile Glu Gly Lys Val Val Gln His Glu Asn Leu Lys Tyr 
    290                 295                 300                 


Thr Val Ile Ile Thr Val His Thr Gly Asp Gln His Gln Val Gly Asn 
305                 310                 315                 320 


Glu Thr Gln Gly Val Thr Ala Glu Ile Thr Pro Gln Ala Ser Thr Ala 
                325                 330                 335     


Glu Ala Ile Leu Pro Glu Tyr Gly Thr Leu Gly Leu Glu Cys Ser Pro 
            340                 345                 350         


Arg Thr Gly Leu Asp Phe Asn Glu Met Ile Leu Leu Thr Met Lys Asn 
        355                 360                 365             


Lys Ala Trp Met Val His Arg Gln Trp Phe Phe Asp Leu Pro Leu Pro 
    370                 375                 380                 


Trp Thr Ser Gly Ala Thr Thr Glu Thr Pro Thr Trp Asn Arg Lys Glu 
385                 390                 395                 400 


Leu Leu Val Thr Phe Lys Asn Ala His Ala Lys Lys Gln Glu Val Val 
                405                 410                 415     


Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala 
            420                 425                 430         


Thr Glu Ile Gln Asn Ser Gly Gly Thr Ser Ile Phe Ala Gly His Leu 
        435                 440                 445             


Lys Cys Arg Leu Lys Met Asp Lys Leu Glu Leu Lys Gly Met Ser Tyr 
    450                 455                 460                 


Ala Met Cys Ser Asn Thr Phe Val Leu Lys Lys Glu Val Ser Glu Thr 
465                 470                 475                 480 


Gln His Gly Thr Ile Leu Ile Lys Val Glu Tyr Lys Gly Glu Asp Ala 
                485                 490                 495     


Pro Cys Lys Ile Pro Phe Ser Thr Glu Asp Gly Gln Gly Lys Ala His 
            500                 505                 510         


Asn Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr Lys Lys Glu Glu 
        515                 520                 525             


Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser Asn Ile Val 
    530                 535                 540                 


Ile Gly Ile Gly Asp Lys Ala Leu Lys Ile Asn Trp Tyr Lys Lys Gly 
545                 550                 555                 560 


Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly Ala Arg Arg 
                565                 570                 575     


Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly 
            580                 585                 590         


Val Leu Asn Ser Leu Gly Lys Met Val His Gln Ile Phe Gly Ser Ala 
        595                 600                 605             


Tyr Thr Ala Leu Phe Ser Gly Val Ser Trp Ile Met Lys Ile Gly Ile 
    610                 615                 620                 


Gly Val Leu Leu Thr Trp Ile Gly Leu Asn Ser Lys Asn Thr Ser Met 
625                 630                 635                 640 


Ser Phe Ser Cys Ile Ala Ile Gly Ile Ile Thr Leu Tyr Leu Gly Ala 
                645                 650                 655     


Val Val Gln Ala 
            660 


<210> 11
<211> 661
<212> PRT
<213> Dengue virus

<400> 11
Met Phe His Leu Ser Thr Arg Asp Gly Glu Pro Leu Met Ile Val Ala 
1               5                   10                  15      


Lys His Glu Arg Gly Arg Pro Leu Leu Phe Lys Thr Thr Glu Gly Ile 
            20                  25                  30          


Asn Lys Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys Glu Asp 
        35                  40                  45              


Thr Val Thr Tyr Lys Cys Pro Leu Leu Val Asn Thr Glu Pro Glu Asp 
    50                  55                  60                  


Ile Asp Cys Trp Cys Asn Leu Thr Ser Ala Trp Val Met Tyr Gly Thr 
65                  70                  75                  80  


Cys Thr Gln Ser Gly Glu Arg Arg Arg Glu Lys Arg Ser Val Ala Leu 
                85                  90                  95      


Thr Pro His Ser Gly Met Gly Leu Glu Thr Arg Ala Glu Thr Trp Met 
            100                 105                 110         


Ser Ser Glu Gly Ala Trp Lys His Ala Gln Arg Val Glu Ser Trp Ile 
        115                 120                 125             


Leu Arg Asn Pro Gly Phe Ala Leu Leu Ala Gly Phe Met Ala Tyr Met 
    130                 135                 140                 


Ile Gly Gln Thr Gly Ile Gln Arg Thr Val Phe Phe Val Leu Met Met 
145                 150                 155                 160 


Leu Val Ala Pro Ser Tyr Met Arg Cys Val Gly Val Gly Asn Arg Asp 
                165                 170                 175     


Phe Val Glu Gly Val Ser Gly Gly Ala Trp Val Asp Leu Val Leu Glu 
            180                 185                 190         


His Gly Gly Cys Val Thr Thr Met Ala Gln Gly Lys Pro Thr Leu Asp 
        195                 200                 205             


Phe Glu Leu Ile Lys Thr Thr Ala Lys Glu Val Ala Leu Leu Arg Thr 
    210                 215                 220                 


Tyr Cys Ile Glu Ala Ser Ile Ser Asn Ile Thr Thr Ala Thr Arg Cys 
225                 230                 235                 240 


Pro Thr Gln Gly Glu Pro Tyr Leu Lys Glu Glu Gln Asp Gln Gln Tyr 
                245                 250                 255     


Ile Cys Arg Arg Asp Val Val Asp Arg Gly Trp Gly Asn Gly Cys Gly 
            260                 265                 270         


Leu Phe Gly Lys Gly Gly Val Val Thr Cys Ala Lys Phe Ser Cys Ser 
        275                 280                 285             


Gly Lys Ile Thr Gly Asn Leu Val Gln Ile Glu Asn Leu Glu Tyr Thr 
    290                 295                 300                 


Val Val Val Thr Val His Asn Gly Asp Thr His Ala Val Gly Asn Asp 
305                 310                 315                 320 


Thr Ser Asn His Gly Val Thr Ala Thr Ile Thr Pro Arg Ser Pro Ser 
                325                 330                 335     


Val Glu Val Lys Leu Pro Asp Tyr Gly Glu Leu Thr Leu Asp Cys Glu 
            340                 345                 350         


Pro Arg Ser Gly Ile Asp Phe Asn Glu Met Ile Leu Met Lys Met Lys 
        355                 360                 365             


Lys Lys Thr Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu Pro Leu 
    370                 375                 380                 


Pro Trp Thr Ala Gly Ala Asp Thr Ser Glu Val His Trp Asn His Lys 
385                 390                 395                 400 


Glu Arg Met Val Thr Phe Lys Val Pro His Ala Lys Arg Gln Asp Val 
                405                 410                 415     


Thr Val Leu Gly Ser Gln Glu Gly Ala Met His Ser Ala Leu Thr Gly 
            420                 425                 430         


Ala Thr Glu Val Asp Ser Gly Asp Gly Asn His Met Phe Ala Gly His 
        435                 440                 445             


Leu Lys Cys Lys Val Arg Met Glu Lys Leu Arg Ile Lys Gly Met Ser 
    450                 455                 460                 


Tyr Thr Met Cys Ser Gly Lys Phe Ser Ile Asp Lys Glu Met Ala Glu 
465                 470                 475                 480 


Thr Gln His Gly Thr Thr Val Val Lys Val Lys Tyr Glu Gly Thr Gly 
                485                 490                 495     


Ala Pro Cys Lys Val Pro Ile Glu Ile Arg Asp Val Asn Lys Glu Lys 
            500                 505                 510         


Val Val Gly Arg Ile Ile Ser Ser Thr Pro Phe Ala Glu Asn Thr Asn 
        515                 520                 525             


Ser Val Thr Asn Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    530                 535                 540                 


Val Ile Gly Val Gly Asp Ser Ala Leu Thr Leu His Trp Phe Arg Lys 
545                 550                 555                 560 


Gly Ser Ser Ile Gly Lys Met Phe Glu Ser Thr Tyr Arg Gly Ala Lys 
                565                 570                 575     


Arg Met Ala Ile Leu Gly Glu Thr Ala Trp Asp Phe Gly Ser Val Gly 
            580                 585                 590         


Gly Leu Phe Thr Ser Leu Gly Lys Ala Val His Gln Val Phe Gly Ser 
        595                 600                 605             


Val Tyr Thr Thr Met Phe Gly Gly Val Ser Trp Met Ile Arg Ile Leu 
    610                 615                 620                 


Ile Gly Phe Leu Val Leu Trp Ile Gly Thr Asn Ser Arg Asn Thr Ser 
625                 630                 635                 640 


Met Ala Met Thr Cys Ile Ala Val Gly Gly Ile Thr Leu Phe Leu Gly 
                645                 650                 655     


Phe Thr Val Gln Ala 
            660     


