                         SEQUENCE LISTING

<110>  CELGENE CORPORATION
 
<120>  USES OF ANTI-BCMA CHIMERIC ANTIGEN RECEPTORS

<130>  14247-321-228

<140>
<141>

<150>  US 62/696,802
<151>  2018-07-11

<160>  36    
<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  1

Arg Ala Ser Glu Ser Val Thr Ile Leu Gly Ser His Leu Ile His 
1               5                   10                  15  


<210>  2
<211>  7
<212>  PRT
<213>  mus musculus

<400>  2

Leu Ala Ser Asn Val Gln Thr 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  mus musculus

<400>  3

Leu Gln Ser Arg Thr Ile Pro Arg Thr 
1               5                   


<210>  4
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  4

Asp Tyr Ser Ile Asn 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  5

Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  6

Asp Tyr Ser Tyr Ala Met Asp Tyr 
1               5               


<210>  7
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  7

Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu Gly 
1               5                   10                  15      


Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile Leu 
            20                  25                  30          


Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  8
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe 
    50                  55                  60                  


Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  9
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-BCMA02 CAR

<400>  9

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr 
    210                 215                 220                 


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp 
225                 230                 235                 240 


Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  10
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-BCMA02 CAR

<400>  10
atggcactcc ccgtcaccgc ccttctcttg cccctcgccc tgctgctgca tgctgccagg       60

cccgacattg tgctcactca gtcacctccc agcctggcca tgagcctggg aaaaagggcc      120

accatctcct gtagagccag tgagtccgtc acaatcttgg ggagccatct tattcactgg      180

tatcagcaga agcccgggca gcctccaacc cttcttattc agctcgcgtc aaacgtccag      240

acgggtgtac ctgccagatt ttctggtagc gggtcccgca ctgattttac actgaccata      300

gatccagtgg aagaagacga tgtggccgtg tattattgtc tgcagagcag aacgattcct      360

cgcacatttg gtgggggtac taagctggag attaagggaa gcacgtccgg ctcagggaag      420

ccgggctccg gcgagggaag cacgaagggg caaattcagc tggtccagag cggacctgag      480

ctgaaaaaac ccggcgagac tgttaagatc agttgtaaag catctggcta taccttcacc      540

gactacagca taaattgggt gaaacgggcc cctggaaagg gcctcaaatg gatgggttgg      600

atcaataccg aaactaggga gcctgcttat gcatatgact tccgcgggag attcgccttt      660

tcactcgaga catctgcctc tactgcttac ctccaaataa acaacctcaa gtatgaagat      720

acagccactt acttttgcgc cctcgactat agttacgcca tggactactg gggacaggga      780

acctccgtta ccgtcagttc cgcggccgca accacaacac ctgctccaag gccccccaca      840

cccgctccaa ctatagccag ccaaccattg agcctcagac ctgaagcttg caggcccgca      900

gcaggaggcg ccgtccatac gcgaggcctg gacttcgcgt gtgatattta tatttgggcc      960

cctttggccg gaacatgtgg ggtgttgctt ctctcccttg tgatcactct gtattgtaag     1020

cgcgggagaa agaagctcct gtacatcttc aagcagcctt ttatgcgacc tgtgcaaacc     1080

actcaggaag aagatgggtg ttcatgccgc ttccccgagg aggaagaagg agggtgtgaa     1140

ctgagggtga aattttctag aagcgccgat gctcccgcat atcagcaggg tcagaatcag     1200

ctctacaatg aattgaatct cggcaggcga gaagagtacg atgttctgga caagagacgg     1260

ggcagggatc ccgagatggg gggaaagccc cggagaaaaa atcctcagga ggggttgtac     1320

aatgagctgc agaaggacaa gatggctgaa gcctatagcg agatcggaat gaaaggcgaa     1380

agacgcagag gcaaggggca tgacggtctg taccagggtc tctctacagc caccaaggac     1440

acttatgatg cgttgcatat gcaagccttg ccaccccgct aatga                     1485


<210>  11
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  12

Asp Gly Gly Gly Ser 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  13

Thr Gly Glu Lys Pro 
1               5   


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  14

Gly Gly Arg Arg 
1               


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  15

Gly Gly Gly Gly Ser 
1               5   


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  16

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  17
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  17

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  18

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  19

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  20

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  21

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  22

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa  is Gly or Ser

<400>  23

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  24

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  25

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  26
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  26

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  27
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  27

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  28
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  28

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  29

Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  30
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  30

Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  31
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  31

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  32
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  32

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            20                  25                  30          


Ile Val Ala Pro Val Lys Gln Thr 
        35                  40  


<210>  33
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  33

Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  34
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  34

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  35
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  35

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  36
<211>  7350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-BCMA02 CAR vector

<400>  36
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatcatat gccagcctat ggtgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc ggttttggca      600

gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat      660

tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa aatgtcgtaa      720

caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag      780

cagagctcgt ttagtgaacc gggtctctct ggttagacca gatctgagcc tgggagctct      840

ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgctcaaag      900

tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt      960

cagtgtggaa aatctctagc agtggcgccc gaacagggac ttgaaagcga aagtaaagcc     1020

agaggagatc tctcgacgca ggactcggct tgctgaagcg cgcacggcaa gaggcgaggg     1080

gcggcgactg gtgagtacgc caaaaatttt gactagcgga ggctagaagg agagagtagg     1140

gtgcgagagc gtcggtatta agcgggggag aattagataa atgggaaaaa attcggttaa     1200

ggccaggggg aaagaaacaa tataaactaa aacatatagt tagggcaagc agggagctag     1260

aacgattcgc agttaatcct ggccttttag agacatcaga aggctgtaga caaatactgg     1320

gacagctaca accatccctt cagacaggat cagaagaact tagatcatta tataatacaa     1380

tagcagtcct ctattgtgtg catcaaagga tagatgtaaa agacaccaag gaagccttag     1440

ataagataga ggaagagcaa aacaaaagta agaaaaaggc acagcaagca gcagctgaca     1500

caggaaacaa cagccaggtc agccaaaatt accctatagt gcagaacctc caggggcaaa     1560

tggtacatca ggccatatca cctagaactt taaattaaga cagcagtaca aatggcagta     1620

ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg ggaaagaata     1680

gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat tacaaaaatt     1740

caaaattttc gggtttatta cagggacagc agagatccag tttggaaagg accagcaaag     1800

ctcctctgga aaggtgaagg ggcagtagta atacaagata atagtgacat aaaagtagtg     1860

ccaagaagaa aagcaaagat catcagggat tatggaaaac agatggcagg tgatgattgt     1920

gtggcaagta gacaggatga ggattaacac atggaaaaga ttagtaaaac accatagctc     1980

tagagcgatc ccgatcttca gacctggagg aggagatatg agggacaatt ggagaagtga     2040

attatataaa tataaagtag taaaaattga accattagga gtagcaccca ccaaggcaaa     2100

gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt tccttgggtt     2160

cttgggagca gcaggaagca ctatgggcgc agcgtcaatg acgctgacgg tacaggccag     2220

acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta ttgaggcgca     2280

acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa gaatcctggc     2340

tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct ctggaaaact     2400

catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc tggaacagat     2460

ttggaatcac acgacctgga tggagtggga cagagaaatt aacaattaca caagcttggt     2520

aggtttaaga atagtttttg ctgtactttc tatagtgaat agagttaggc agggatattc     2580

accattatcg tttcagaccc acctcccaac cccgagggga cccgacaggc ccgaaggaat     2640

agaagaagaa ggtggagaga gagacagaga cagatccatt cgattagtga acggatccat     2700

ctcgacggaa tgaaagaccc cacctgtagg tttggcaagc taggatcaag gttaggaaca     2760

gagagacagc agaatatggg ccaaacagga tatctgtggt aagcagttcc tgccccggct     2820

cagggccaag aacagttgga acagcagaat atgggccaaa caggatatct gtggtaagca     2880

gttcctgccc cggctcaggg ccaagaacag atggtcccca gatgcggtcc cgccctcagc     2940

agtttctaga gaaccatcag atgtttccag ggtgccccaa ggacctgaaa tgaccctgtg     3000

ccttatttga actaaccaat cagttcgctt ctcgcttctg ttcgcgcgct tctgctcccc     3060

gagctcaata aaagagccca caacccctca ctcggcgcga ttcacctgac gcgtctacgc     3120

caccatggca ctccccgtca ccgcccttct cttgcccctc gccctgctgc tgcatgctgc     3180

caggcccgac attgtgctca ctcagtcacc tcccagcctg gccatgagcc tgggaaaaag     3240

ggccaccatc tcctgtagag ccagtgagtc cgtcacaatc ttggggagcc atcttattca     3300

ctggtatcag cagaagcccg ggcagcctcc aacccttctt attcagctcg cgtcaaacgt     3360

ccagacgggt gtacctgcca gattttctgg tagcgggtcc cgcactgatt ttacactgac     3420

catagatcca gtggaagaag acgatgtggc cgtgtattat tgtctgcaga gcagaacgat     3480

tcctcgcaca tttggtgggg gtactaagct ggagattaag ggaagcacgt ccggctcagg     3540

gaagccgggc tccggcgagg gaagcacgaa ggggcaaatt cagctggtcc agagcggacc     3600

tgagctgaaa aaacccggcg agactgttaa gatcagttgt aaagcatctg gctatacctt     3660

caccgactac agcataaatt gggtgaaacg ggcccctgga aagggcctca aatggatggg     3720

ttggatcaat accgaaacta gggagcctgc ttatgcatat gacttccgcg ggagattcgc     3780

cttttcactc gagacatctg cctctactgc ttacctccaa ataaacaacc tcaagtatga     3840

agatacagcc acttactttt gcgccctcga ctatagttac gccatggact actggggaca     3900

gggaacctcc gttaccgtca gttccgcggc cgcaaccaca acacctgctc caaggccccc     3960

cacacccgct ccaactatag ccagccaacc attgagcctc agacctgaag cttgcaggcc     4020

cgcagcagga ggcgccgtcc atacgcgagg cctggacttc gcgtgtgata tttatatttg     4080

ggcccctttg gccggaacat gtggggtgtt gcttctctcc cttgtgatca ctctgtattg     4140

taagcgcggg agaaagaagc tcctgtacat cttcaagcag ccttttatgc gacctgtgca     4200

aaccactcag gaagaagatg ggtgttcatg ccgcttcccc gaggaggaag aaggagggtg     4260

tgaactgagg gtgaaatttt ctagaagcgc cgatgctccc gcatatcagc agggtcagaa     4320

tcagctctac aatgaattga atctcggcag gcgagaagag tacgatgttc tggacaagag     4380

acggggcagg gatcccgaga tggggggaaa gccccggaga aaaaatcctc aggaggggtt     4440

gtacaatgag ctgcagaagg acaagatggc tgaagcctat agcgagatcg gaatgaaagg     4500

cgaaagacgc agaggcaagg ggcatgacgg tctgtaccag ggtctctcta cagccaccaa     4560

ggacacttat gatgcgttgc atatgcaagc cttgccaccc cgctaatgac aggtaccttt     4620

aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag aaaagggggg     4680

actggaaggg ctaattcact cccaaagaag acaagatctg ctttttgcct gtactgggtc     4740

tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct     4800

taagcctcaa taaagcttgc cttgagtgct tcaatgtgtg tgttggtttt ttgtgtgtcg     4860

aaattctagc gattctagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg     4920

ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg     4980

tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc     5040

gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt     5100

gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct     5160

gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga     5220

taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc     5280

cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg     5340

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg     5400

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt     5460

tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt     5520

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg     5580

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact     5640

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt     5700

cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct     5760

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac     5820

cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc     5880

tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg     5940

ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta     6000

aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca     6060

atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc     6120

ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc     6180

tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc     6240

agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat     6300

taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt     6360

tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc     6420

cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag     6480

ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt     6540

tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac     6600

tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg     6660

cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat     6720

tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc     6780

gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc     6840

tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa     6900

atgttgaata ctcatactct tcctttttca atattattga agcatttatc agggttattg     6960

tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg     7020

cacatttccc cgaaaagtgc cacctgggac tagctttttg caaaagccta ggcctccaaa     7080

aaagcctcct cactacttct ggaatagctc agaggccgag gcggcctcgg cctctgcata     7140

aataaaaaaa attagtcagc catggggcgg agaatgggcg gaactgggcg gagttagggg     7200

cgggatgggc ggagttaggg gcgggactat ggttgctgac taattgagat gagcttgcat     7260

gccgacattg attattgact agtccctaag aaaccattct tatcatgaca ttaacctata     7320

aaaataggcg tatcacgagg ccctttcgtc                                      7350


