                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
       Huffman, Mark A.
       Fryszkowska, Anna
       Kolev, Joshua N.
       Devine, Paul N.
       Campos, Kevin R.
       Truppo, Matthew
       Nawrat, Christopher C.
 
<120>  ENZYMATIC SYNTHESIS OF 4'-ETHYNYL NUCLEOSIDE ANALOGS

<130>  24608-WO-PCT

<150>  62/695508
<151>  2018-07-09

<150>  62/822320
<151>  2019-03-22

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  657
<212>  PRT
<213>  Fusarium graminearum

<400>  1

Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      


Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          


Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              


Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  


Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  


Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      


Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         


Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             


Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 


Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 


Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     


Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         


Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             


Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 


His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 


Val Val Asp Glu Thr Ala Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser 
                245                 250                 255     


Leu Tyr Asp Ser Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln 
            260                 265                 270         


Val Ala Arg Gly Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val 
        275                 280                 285             


Phe Thr Ile Gly Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly 
    290                 295                 300                 


Glu Val Tyr Ser Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala 
305                 310                 315                 320 


Lys Val Asn Pro Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser 
                325                 330                 335     


Asp Asn His Ala Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln 
            340                 345                 350         


Ala Gly Pro Ser Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly 
        355                 360                 365             


Asp Val Lys Ser Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro 
    370                 375                 380                 


Asp Ala Met Cys Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys 
385                 390                 395                 400 


Ile Leu Thr Phe Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr 
                405                 410                 415     


Thr Asn Ala His Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn 
            420                 425                 430         


Thr Val Phe Ala Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr 
        435                 440                 445             


Ser Val Val Leu Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg 
    450                 455                 460                 


Arg Gly Ile Pro Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile 
465                 470                 475                 480 


Tyr Val Pro Glu Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile 
                485                 490                 495     


Val Arg Ala Tyr His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val 
            500                 505                 510         


Phe Asn Gly Gly Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe 
        515                 520                 525             


Asp Ala Gln Ile Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn 
    530                 535                 540                 


Leu Ala Thr Arg Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys 
545                 550                 555                 560 


Val Gly Gly Arg Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala 
                565                 570                 575     


Ser Leu Ile Arg Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln 
            580                 585                 590         


Arg Arg Ile Pro Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser 
        595                 600                 605             


Phe Gln Val Pro Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met 
    610                 615                 620                 


Leu Phe Val Met Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile 
625                 630                 635                 640 


Arg Val Thr Gln Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu 
                645                 650                 655     


Lys 
    


<210>  2
<211>  316
<212>  PRT
<213>  Escherichia coli

<400>  2

Met Ser Ile Lys Glu Gln Thr Leu Met Thr Pro Tyr Leu Gln Phe Asp 
1               5                   10                  15      


Arg Asn Gln Trp Ala Ala Leu Arg Asp Ser Val Pro Met Thr Leu Ser 
            20                  25                  30          


Glu Asp Glu Ile Ala Arg Leu Lys Gly Ile Asn Glu Asp Leu Ser Leu 
        35                  40                  45              


Glu Glu Val Ala Glu Ile Tyr Leu Pro Leu Ser Arg Leu Leu Asn Phe 
    50                  55                  60                  


Tyr Ile Ser Ser Asn Leu Arg Arg Gln Ala Val Leu Glu Gln Phe Leu 
65                  70                  75                  80  


Gly Thr Asn Gly Gln Arg Ile Pro Tyr Ile Ile Ser Ile Ala Gly Ser 
                85                  90                  95      


Val Ala Val Gly Lys Ser Thr Thr Ala Arg Val Leu Gln Ala Leu Leu 
            100                 105                 110         


Ser Arg Trp Pro Glu His Arg Arg Val Glu Leu Ile Thr Thr Asp Gly 
        115                 120                 125             


Phe Leu His Pro Asn Gln Val Leu Lys Glu Arg Gly Leu Met Lys Lys 
    130                 135                 140                 


Lys Gly Phe Pro Glu Ser Tyr Asp Met His Arg Leu Val Lys Phe Val 
145                 150                 155                 160 


Ser Asp Leu Lys Ser Gly Val Pro Asn Val Thr Ala Pro Val Tyr Ser 
                165                 170                 175     


His Leu Ile Tyr Asp Val Ile Pro Asp Gly Asp Lys Thr Val Val Gln 
            180                 185                 190         


Pro Asp Ile Leu Ile Leu Glu Gly Leu Asn Val Leu Gln Ser Gly Met 
        195                 200                 205             


Asp Tyr Pro His Asp Pro His His Val Phe Val Ser Asp Phe Val Asp 
    210                 215                 220                 


Phe Ser Ile Tyr Val Asp Ala Pro Glu Asp Leu Leu Gln Thr Trp Tyr 
225                 230                 235                 240 


Ile Asn Arg Phe Leu Lys Phe Arg Glu Gly Ala Phe Thr Asp Pro Asp 
                245                 250                 255     


Ser Tyr Phe His Asn Tyr Ala Lys Leu Thr Lys Glu Glu Ala Ile Lys 
            260                 265                 270         


Thr Ala Met Thr Ile Trp Lys Glu Met Asn Trp Leu Asn Leu Lys Gln 
        275                 280                 285             


Asn Ile Leu Pro Thr Arg Glu Arg Ala Ser Leu Ile Leu Thr Lys Ser 
    290                 295                 300                 


Ala Asn His Ala Val Glu Glu Val Arg Leu Arg Lys 
305                 310                 315     


<210>  3
<211>  413
<212>  PRT
<213>  Thermotoga maritima

<400>  3

Met Gly Ser His His His His His His Gly Ser Arg Val Leu Val Ile 
1               5                   10                  15      


Asn Ser Gly Ser Ser Ser Ile Lys Tyr Gln Leu Ile Glu Met Glu Gly 
            20                  25                  30          


Glu Lys Val Leu Cys Lys Gly Ile Ala Glu Arg Ile Gly Ile Glu Gly 
        35                  40                  45              


Ser Arg Leu Val His Arg Val Gly Asp Glu Lys His Val Ile Glu Arg 
    50                  55                  60                  


Glu Leu Pro Asp His Glu Glu Ala Leu Lys Leu Ile Leu Asn Thr Leu 
65                  70                  75                  80  


Val Asp Glu Lys Leu Gly Val Ile Lys Asp Leu Lys Glu Ile Asp Ala 
                85                  90                  95      


Val Gly His Arg Val Val His Gly Gly Glu Arg Phe Lys Glu Ser Val 
            100                 105                 110         


Leu Val Asp Glu Glu Val Leu Lys Ala Ile Glu Glu Val Ser Pro Leu 
        115                 120                 125             


Ala Pro Leu His Asn Pro Ala Asn Leu Met Gly Ile Lys Ala Ala Met 
    130                 135                 140                 


Lys Leu Leu Pro Gly Val Pro Asn Val Ala Val Phe Asp Thr Ala Phe 
145                 150                 155                 160 


His Gln Thr Ile Pro Gln Lys Ala Tyr Leu Tyr Ala Ile Pro Tyr Glu 
                165                 170                 175     


Tyr Tyr Glu Lys Tyr Lys Ile Arg Arg Tyr Gly Phe His Gly Thr Ser 
            180                 185                 190         


His Arg Tyr Val Ser Lys Arg Ala Ala Glu Ile Leu Gly Lys Lys Leu 
        195                 200                 205             


Glu Glu Leu Lys Ile Ile Thr Cys His Ile Gly Asn Gly Ala Ser Val 
    210                 215                 220                 


Ala Ala Val Lys Tyr Gly Lys Cys Val Asp Thr Ser Met Gly Phe Thr 
225                 230                 235                 240 


Pro Leu Glu Gly Leu Val Met Gly Thr Arg Ser Gly Asp Leu Asp Pro 
                245                 250                 255     


Ala Ile Pro Phe Phe Ile Met Glu Lys Glu Gly Ile Ser Pro Gln Glu 
            260                 265                 270         


Met Tyr Asp Ile Leu Asn Lys Lys Ser Gly Val Tyr Gly Leu Ser Lys 
        275                 280                 285             


Gly Phe Ser Ser Asp Met Arg Asp Ile Glu Glu Ala Ala Leu Lys Gly 
    290                 295                 300                 


Asp Glu Trp Cys Lys Leu Val Leu Glu Ile Tyr Asp Tyr Arg Ile Ala 
305                 310                 315                 320 


Lys Tyr Ile Gly Ala Tyr Ala Ala Ala Met Asn Gly Val Asp Ala Ile 
                325                 330                 335     


Val Phe Thr Ala Gly Val Gly Glu Asn Ser Pro Ile Thr Arg Glu Asp 
            340                 345                 350         


Val Cys Ser Tyr Leu Glu Phe Leu Gly Val Lys Leu Asp Lys Gln Lys 
        355                 360                 365             


Asn Glu Glu Thr Ile Arg Gly Lys Glu Gly Ile Ile Ser Thr Pro Asp 
    370                 375                 380                 


Ser Arg Val Lys Val Leu Val Val Pro Thr Asn Glu Glu Leu Met Ile 
385                 390                 395                 400 


Ala Arg Asp Thr Lys Glu Ile Val Glu Lys Ile Gly Arg 
                405                 410             


<210>  4
<211>  613
<212>  PRT
<213>  Streptococcus thermophilus

<400>  4

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Thr Val Gly Lys Thr Lys Val Ser Thr Ala Ser 
            20                  25                  30          


Leu Lys Val Leu Ala Gly Trp Gly Ile Asp Thr Ile Tyr Gly Ile Pro 
        35                  40                  45              


Ser Gly Thr Leu Ala Pro Leu Met Glu Ala Leu Gly Glu Gln Glu Glu 
    50                  55                  60                  


Thr Asp Ile Lys Phe Leu Gln Val Lys His Glu Glu Val Gly Ala Met 
65                  70                  75                  80  


Ala Ala Val Met Gln Trp Lys Phe Gly Gly Lys Leu Gly Val Cys Val 
                85                  90                  95      


Gly Ser Gly Gly Pro Gly Ala Ser His Leu Ile Asn Gly Leu Tyr Asp 
            100                 105                 110         


Ala Ala Met Asp Asn Thr Pro Val Leu Ala Ile Leu Gly Ser Pro Pro 
        115                 120                 125             


Gln Arg Glu Leu Asn Met Asp Ala Phe Gln Glu Leu Asn Gln Asn Pro 
    130                 135                 140                 


Met Tyr Asp His Ile Ala Val Tyr Asn Arg Arg Val Ala Tyr Ala Glu 
145                 150                 155                 160 


Gln Leu Pro Lys Leu Ile Asp Asp Ala Ile Arg Thr Ala Ile Ser Lys 
                165                 170                 175     


Arg Gly Val Ala Val Leu Glu Val Pro Gly Asp Phe Gly Tyr Lys Glu 
            180                 185                 190         


Ile Ala Asn Asp Ala Phe Tyr Ser Ser Gly His Ser Tyr Arg Asp Tyr 
        195                 200                 205             


Val Ser Ser Ala Ile Asn Glu Val Asp Ile Asp Ala Ala Val Glu Val 
    210                 215                 220                 


Leu Asn Lys Ser Lys Arg Ala Val Ile Tyr Ala Gly Ile Gly Thr Met 
225                 230                 235                 240 


Gly His Gly Pro Ala Val Gln Glu Leu Ser Arg Lys Ile Lys Ala Pro 
                245                 250                 255     


Ile Ile Thr Thr Ala Lys Asn Phe Glu Thr Phe Asp Tyr Asp Phe Glu 
            260                 265                 270         


Gly Leu Thr Gly Ser Thr Tyr Arg Val Gly Trp Lys Pro Ala Asn Glu 
        275                 280                 285             


Ala Val Lys Glu Ala Asp Thr Val Leu Phe Val Gly Ser Asn Phe Pro 
    290                 295                 300                 


Phe Ala Glu Val Glu Gly Thr Phe Ser Asn Val Glu Asn Phe Ile Gln 
305                 310                 315                 320 


Ile Asp Asn Asn Pro Thr Met Leu Gly Lys Arg His Asn Ala Asp Val 
                325                 330                 335     


Ala Ile Leu Gly Asp Ala Gly Glu Ala Val Gln Met Leu Leu Glu Lys 
            340                 345                 350         


Val Ala Pro Val Glu Glu Ser Ala Trp Trp Asn Ala Asn Leu Lys Asn 
        355                 360                 365             


Ile Gln Asn Trp Arg Asp Tyr Met Thr Lys Leu Glu Thr Lys Glu Asn 
    370                 375                 380                 


Gly Pro Leu Gln Leu Tyr Gln Val Tyr Asn Ala Ile Asn Lys Tyr Ala 
385                 390                 395                 400 


Asp Glu Asp Ala Ile Tyr Ser Ile Asp Val Gly Asn Thr Thr Gln Thr 
                405                 410                 415     


Ser Ile Arg His Leu His Met Thr Pro Lys Asn Met Trp Arg Thr Ser 
            420                 425                 430         


Pro Leu Phe Ala Ser Met Gly Ile Ala Leu Pro Gly Gly Ile Gly Ala 
        435                 440                 445             


Lys Asn Val Tyr Pro Glu Arg Gln Val Phe Asn Leu Met Gly Asp Gly 
    450                 455                 460                 


Ala Phe Ser Met Asn Tyr Gln Asp Ile Val Thr Asn Val Arg Tyr Asn 
465                 470                 475                 480 


Met Pro Val Ile Asn Val Val Phe Thr Asn Thr Glu Tyr Gly Phe Ile 
                485                 490                 495     


Lys Asn Lys Tyr Glu Asp Thr Asn Thr Asn Thr Phe Gly Thr Glu Phe 
            500                 505                 510         


Thr Asp Val Asp Tyr Ala Met Ile Gly Glu Ala Gln Gly Ala Val Gly 
        515                 520                 525             


Phe Thr Val Ser Arg Ile Glu Asp Met Asp Gln Val Met Ala Ala Ala 
    530                 535                 540                 


Val Lys Ala Asn Lys Glu Gly Lys Thr Val Val Ile Asp Ala Lys Ile 
545                 550                 555                 560 


Thr Lys Asp Arg Pro Ile Pro Val Glu Thr Leu Lys Leu Asp Pro Ala 
                565                 570                 575     


Leu Tyr Ser Glu Glu Glu Ile Lys Ala Tyr Lys Glu Arg Tyr Glu Ala 
            580                 585                 590         


Glu Glu Leu Val Pro Phe Ser Glu Phe Leu Lys Ala Glu Gly Leu Glu 
        595                 600                 605             


Ser Lys Val Ala Lys 
    610             


<210>  5
<211>  257
<212>  PRT
<213>  Shewanella halifaxensis

<400>  5

Met Ser Asp Leu Lys Lys Ala Ala Gln Gln Ala Ile Ser Leu Met Asp 
1               5                   10                  15      


Leu Thr Thr Leu Asn Asp Asp Asp Thr Asp Gln Lys Val Ile Glu Leu 
            20                  25                  30          


Cys His Lys Ala Lys Thr Pro Ala Gly Asp Thr Ala Ala Ile Cys Ile 
        35                  40                  45              


Tyr Pro Arg Phe Ile Pro Ile Ala Arg Lys Thr Leu Asn Glu Ile Gly 
    50                  55                  60                  


Gly Asp Asp Ile Lys Ile Ala Thr Val Thr Asn Phe Pro His Gly Asn 
65                  70                  75                  80  


Asp Asp Ile Ala Ile Ala Val Leu Glu Thr Arg Ala Ala Val Ala Tyr 
                85                  90                  95      


Gly Ala Asp Glu Val Asp Val Val Phe Pro Tyr Arg Ala Leu Met Glu 
            100                 105                 110         


Gly Asn Glu Thr Val Gly Phe Glu Leu Val Lys Ala Cys Lys Glu Ala 
        115                 120                 125             


Cys Gly Glu Asp Thr Ile Leu Lys Val Ile Ile Glu Ser Gly Val Leu 
    130                 135                 140                 


Ala Asp Pro Ala Leu Ile Arg Lys Ala Ser Glu Leu Ser Ile Asp Ala 
145                 150                 155                 160 


Gly Ala Asp Phe Ile Lys Thr Ser Thr Gly Lys Val Ala Val Asn Ala 
                165                 170                 175     


Thr Leu Glu Ala Ala Glu Ile Met Met Thr Val Ile Ser Glu Lys Asn 
            180                 185                 190         


Pro Lys Val Gly Phe Lys Pro Ala Gly Gly Val Lys Asp Ala Ala Ala 
        195                 200                 205             


Ala Ala Glu Phe Leu Gly Val Ala Ala Arg Leu Leu Gly Asp Asp Trp 
    210                 215                 220                 


Ala Thr Pro Ala Thr Phe Arg Phe Gly Ala Ser Ser Leu Leu Thr Asn 
225                 230                 235                 240 


Leu Leu His Thr Leu Glu Leu Ala Asp Ala Pro Gln Gly Ala Gln Gly 
                245                 250                 255     


Tyr 
    


<210>  6
<211>  257
<212>  PRT
<213>  Shewanella halifaxensis

<400>  6

Met Cys Asp Leu Lys Lys Ala Ala Gln Arg Ala Ile Ser Leu Met Asp 
1               5                   10                  15      


Leu Thr Thr Leu Asn Asp Asp Asp Thr Asp Gln Lys Val Ile Glu Leu 
            20                  25                  30          


Cys His Lys Ala Lys Thr Pro Ala Gly Asp Thr Ala Ala Ile Val Ile 
        35                  40                  45              


Tyr Pro Arg Phe Ile Pro Ile Ala Arg Lys Thr Leu Asn Glu Ile Gly 
    50                  55                  60                  


Gly Leu Asp Ile Lys Ile Val Thr Val Thr Asn Phe Pro His Gly Asn 
65                  70                  75                  80  


Asp Asp Ile Ala Ile Ala Val Leu Glu Thr Arg Ala Ala Val Ala Tyr 
                85                  90                  95      


Gly Ala Asp Glu Val Asp Val Val Phe Pro Tyr Arg Ala Leu Met Glu 
            100                 105                 110         


Gly Asn Glu Thr Val Gly Phe Glu Leu Val Lys Ala Cys Lys Glu Ala 
        115                 120                 125             


Cys Gly Glu Asp Thr Ile Leu Lys Val Ile Ile Glu Ser Gly Val Leu 
    130                 135                 140                 


Lys Asp Pro Ala Leu Ile Arg Lys Ala Ser Glu Ile Ser Ile Asp Ala 
145                 150                 155                 160 


Gly Ala Asp Phe Ile Lys Thr Ser Thr Gly Lys Val Ala Val Asn Ala 
                165                 170                 175     


Thr Leu Glu Ala Ala Glu Ile Ile Met Thr Val Ile Ser Glu Lys Asn 
            180                 185                 190         


Pro Lys Val Gly Phe Lys Pro Ala Gly Gly Ile Lys Asp Ala Ala Ala 
        195                 200                 205             


Ala Ala Glu Phe Leu Gly Val Ala Ala Arg Leu Leu Gly Asp Asp Trp 
    210                 215                 220                 


Ala Thr Pro Ala Thr Phe Arg Phe Gly Ala Thr Asp Leu Leu Thr Asn 
225                 230                 235                 240 


Leu Leu His Thr Leu Glu Leu Ala Asp Ala Pro Gln Gly Ala Gln Gly 
                245                 250                 255     


Tyr 
    


<210>  7
<211>  500
<212>  PRT
<213>  Alloscardovia omnicolens

<400>  7

Met Lys Asn Lys Val Gln Leu Ile Thr Tyr Ala Asp Arg Leu Gly Asp 
1               5                   10                  15      


Gly Thr Leu Lys Ser Met Thr Glu Thr Leu Arg Lys His Phe Glu Gly 
            20                  25                  30          


Val Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              


Ala Asp Ala Gly Phe Asp Pro Val Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  


Leu Gly Ser Trp Asp Asp Val Ala Glu Leu Ser Thr Thr His Asp Ile 
65                  70                  75                  80  


Met Val Asp Thr Ile Val Asn His Met Ser Trp Glu Ser Glu Gln Phe 
                85                  90                  95      


Gln Asp Val Met Ala Lys Gly Glu Asp Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         


Leu Thr Met Ser Ser Ile Phe Pro Asp Gly Val Thr Glu Glu Asp Leu 
        115                 120                 125             


Thr Ala Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr His Tyr Asn 
    130                 135                 140                 


Trp Gly Gly Lys Thr Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 


Val Asp Ile Asp Thr Asp Ser Glu Met Gly Trp Asn Tyr Leu Leu Ser 
                165                 170                 175     


Ile Leu Asp Gln Leu Ser Gln Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         


Ala Val Gly Tyr Gly Ala Lys Glu Lys Asn Ser Ser Cys Phe Met Thr 
        195                 200                 205             


Pro Lys Thr Phe Lys Leu Ile Glu Arg Ile Lys Ala Glu Gly Glu Lys 
    210                 215                 220                 


Arg Gly Leu Glu Thr Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 


Val Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Ile Pro 
                245                 250                 255     


Gly Leu Leu Leu His Ala Leu Glu Phe Gly Lys Thr Asp Ala Leu Ala 
            260                 265                 270         


Gln Trp Ile Asp Val Arg Pro Asn Asn Ala Val Asn Val Leu Asp Thr 
        275                 280                 285             


His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Met Asp Arg 
    290                 295                 300                 


Ser Leu Ala Gly Leu Val Pro Asp Glu Glu Val Asp Ala Leu Val Glu 
305                 310                 315                 320 


Ser Ile His Arg Asn Ser Lys Gly Glu Ser Gln Glu Ala Thr Gly Ala 
                325                 330                 335     


Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ala 
            340                 345                 350         


Ala Leu Gly Ser Asp Asp Gln Lys Tyr Ile Ala Ala Arg Ala Val Gln 
        355                 360                 365             


Phe Phe Met Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 


Gly Ser Asn Asp Met Asp Leu Leu Lys Arg Thr Asn Val Gly Arg Asp 
385                 390                 395                 400 


Ile Asn Arg His Tyr Tyr Ser Ala Ala Glu Val Ala Ser Glu Val Glu 
                405                 410                 415     


Arg Pro Val Val Gln Ala Leu Asn Ala Leu Gly Arg Phe Arg Asn Thr 
            420                 425                 430         


Leu Ser Ala Phe Asp Gly Glu Phe Ser Tyr Ser Asn Ala Asp Gly Val 
        435                 440                 445             


Leu Thr Met Thr Trp Ala Asp Asp Ala Thr Arg Ala Thr Leu Thr Phe 
    450                 455                 460                 


Ala Pro Lys Ala Asn Ser Asn Gly Ala Ser Val Ala Arg Leu Glu Trp 
465                 470                 475                 480 


Thr Asp Ala Ala Gly Glu His Ala Thr Asp Asp Leu Ile Ala Asn Pro 
                485                 490                 495     


Pro Val Val Ala 
            500 


<210>  8
<211>  407
<212>  PRT
<213>  Escherichia coli

<400>  8

Met Lys Arg Ala Phe Ile Met Val Leu Asp Ser Phe Gly Ile Gly Ala 
1               5                   10                  15      


Thr Glu Asp Ala Glu Arg Phe Gly Asp Val Gly Ala Asp Thr Leu Gly 
            20                  25                  30          


His Ile Ala Glu Ala Cys Ala Lys Gly Glu Ala Asp Asn Gly Arg Lys 
        35                  40                  45              


Gly Pro Leu Asn Leu Pro Asn Leu Thr Arg Leu Gly Leu Ala Lys Ala 
    50                  55                  60                  


His Glu Gly Ser Thr Gly Phe Ile Pro Ala Gly Met Asp Gly Asn Ala 
65                  70                  75                  80  


Glu Val Ile Gly Ala Tyr Ala Trp Ala His Glu Met Ser Ser Gly Lys 
                85                  90                  95      


Asp Ser Val Ser Gly His Trp Glu Ile Ala Gly Val Pro Val Leu Phe 
            100                 105                 110         


Glu Trp Gly Tyr Phe Ser Asp His Glu Asn Ser Phe Pro Gln Glu Leu 
        115                 120                 125             


Leu Asp Lys Leu Val Glu Arg Ala Asn Leu Pro Gly Tyr Leu Gly Asn 
    130                 135                 140                 


Cys Arg Ser Ser Gly Thr Val Ile Leu Asp Gln Leu Gly Glu Glu His 
145                 150                 155                 160 


Met Lys Thr Gly Lys Pro Ile Phe Tyr Thr Ser Ala Ala Ser Val Phe 
                165                 170                 175     


Gln Ile Ala Cys His Glu Glu Thr Phe Gly Leu Asp Lys Leu Tyr Glu 
            180                 185                 190         


Leu Cys Glu Ile Ala Arg Glu Glu Leu Thr Asn Gly Gly Tyr Asn Ile 
        195                 200                 205             


Gly Arg Val Ile Ala Arg Pro Phe Ile Gly Asp Lys Ala Gly Asn Phe 
    210                 215                 220                 


Gln Arg Thr Gly Asn Arg Arg Asp Leu Ala Val Glu Pro Pro Ala Pro 
225                 230                 235                 240 


Thr Val Leu Gln Lys Leu Val Asp Glu Lys His Gly Gln Val Val Ser 
                245                 250                 255     


Val Gly Lys Ile Ala Asp Ile Tyr Ala Asn Cys Gly Ile Thr Lys Lys 
            260                 265                 270         


Val Lys Ala Thr Gly Leu Asp Ala Leu Phe Asp Ala Thr Ile Lys Glu 
        275                 280                 285             


Met Lys Glu Ala Gly Asp Asn Thr Ile Val Phe Thr Asn Phe Val Asp 
    290                 295                 300                 


Phe Asp Ser Ser Trp Gly His Arg Arg Asp Val Ala Gly Tyr Ala Ala 
305                 310                 315                 320 


Gly Leu Glu Leu Phe Asp Arg Arg Leu Pro Glu Leu Met Ser Leu Leu 
                325                 330                 335     


Arg Asp Asp Asp Ile Leu Ile Leu Thr Ala Asp His Gly Cys Asp Pro 
            340                 345                 350         


Thr Trp Thr Gly Thr Asp His Thr Arg Glu His Ile Pro Val Leu Val 
        355                 360                 365             


Tyr Gly Pro Lys Val Lys Pro Gly Ser Leu Gly His Arg Glu Thr Phe 
    370                 375                 380                 


Ala Asp Ile Gly Gln Thr Leu Ala Lys Tyr Phe Gly Thr Ser Asp Met 
385                 390                 395                 400 


Glu Tyr Gly Lys Ala Met Phe 
                405         


<210>  9
<211>  239
<212>  PRT
<213>  Escherichia coli

<400>  9

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Ala Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  10
<211>  650
<212>  PRT
<213>  Fusarium graminearum

<400>  10

Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      


Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          


Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              


Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  


Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  


Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      


Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         


Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             


Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 


Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 


Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     


Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         


Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             


Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 


His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 


Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     


Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         


Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             


Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 


Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 


Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     


Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         


Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             


Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 


Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 


Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     


Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         


Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             


Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 


Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 


Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     


His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         


Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             


Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 


Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 


Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     


Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         


Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             


Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 


Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 


Gly Gln Thr Gly His His His His His His 
                645                 650 


<210>  11
<211>  650
<212>  PRT
<213>  Fusarium graminearum

<400>  11

Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      


Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          


Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              


Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  


Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  


Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      


Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         


Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             


Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 


Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 


Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     


Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         


Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             


Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 


His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 


Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     


Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         


Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             


Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 


Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 


Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     


Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         


Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             


Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 


Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 


Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     


Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         


Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             


Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 


Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 


Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     


His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         


Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             


Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 


Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 


Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     


Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         


Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             


Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 


Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 


Gly Gln Thr Gly His His His His His His 
                645                 650 


<210>  12
<211>  316
<212>  PRT
<213>  Escherichia coli

<400>  12

Met Ser Ile Lys Glu Gln Thr Leu Met Thr Pro Tyr Leu Gln Leu Asp 
1               5                   10                  15      


Arg Asn Gln Trp Ala Ala Leu Arg Asp Ser Asn Pro Met Thr Leu Ser 
            20                  25                  30          


Glu Asp Glu Ile Ala Arg Leu Lys Gly Ile Asn Glu Asp Leu Ser Leu 
        35                  40                  45              


Glu Glu Val Ala Glu Val Tyr Leu Pro Leu Ser Arg Leu Leu Asn Phe 
    50                  55                  60                  


Tyr Ile Ser Ser Asn Leu Arg Arg Gln Ala Val Leu Glu Gln Phe Leu 
65                  70                  75                  80  


Gly Thr Asn Gly Gln Arg Ile Pro Tyr Ile Ile Ser Ile Ala Gly Ser 
                85                  90                  95      


Val Ala Val Gly Lys Ser Thr Thr Ala Arg Val Leu Gln Ala Leu Leu 
            100                 105                 110         


Ser Arg Trp Pro Glu His Arg Arg Val Glu Leu Ile Thr Thr Asp Gly 
        115                 120                 125             


Phe Leu His Pro Asn Gln Val Leu Lys Glu Arg Gly Leu Met Lys Lys 
    130                 135                 140                 


Lys Gly Phe Pro Glu Ser Tyr Asp Met His Arg Leu Met Lys Phe Val 
145                 150                 155                 160 


Lys Asp Leu Lys Ser Gly Val Pro Asn Val Thr Ala Pro Val Tyr Ser 
                165                 170                 175     


His Leu Ile Tyr Asp Val Ile Pro Asp Gly Asp Lys Thr Val Val Gln 
            180                 185                 190         


Pro Asp Ile Leu Ile Leu Glu Gly Leu Asn Val Leu Gln Ser Gly Met 
        195                 200                 205             


Asp Tyr Pro His Asp Pro His His Val Phe Val Ser Asp Phe Val Asp 
    210                 215                 220                 


Phe Ser Ile Tyr Val Asp Ala Pro Glu Asp Leu Leu Gln Thr Trp Tyr 
225                 230                 235                 240 


Ile Asn Arg Phe Leu Lys Phe Arg Glu Gly Ala Phe Thr Asp Pro Asp 
                245                 250                 255     


Ser Tyr Phe His Gly Tyr Ala Lys Leu Thr Lys Glu Glu Ala Ile Lys 
            260                 265                 270         


Thr Ala Met Thr Ile Trp Lys Glu Met Asn His Leu Asn Leu Lys Gln 
        275                 280                 285             


Asn Ile Leu Pro Thr Arg Glu Arg Ala Ser Leu Ile Leu Thr Lys Ser 
    290                 295                 300                 


Ala Asn His Ile Val Glu Glu Val Arg Leu Arg Lys 
305                 310                 315     


<210>  13
<211>  325
<212>  PRT
<213>  Escherichia coli

<400>  13

Met His His His His His His Gly Gly Met Ser Ile Lys Glu Gln Thr 
1               5                   10                  15      


Leu Met Thr Pro Tyr Leu Gln Leu Asp Arg Asn Gln Trp Ala Ala Leu 
            20                  25                  30          


Arg Asp Ser Asn Pro Met Thr Leu Ser Glu Asp Glu Ile Ala Arg Leu 
        35                  40                  45              


Lys Gly Ile Asn Glu Asp Leu Ser Leu Glu Glu Val Ala Glu Val Tyr 
    50                  55                  60                  


Leu Pro Leu Ser Arg Leu Leu Asn Phe Tyr Ile Ser Ser Asn Leu Arg 
65                  70                  75                  80  


Arg Gln Ala Val Leu Glu Gln Phe Leu Gly Thr Asn Gly Gln Arg Ile 
                85                  90                  95      


Pro Tyr Ile Ile Ser Ile Ala Gly Ser Val Ala Val Gly Lys Ser Thr 
            100                 105                 110         


Thr Ala Arg Val Leu Gln Ala Leu Leu Ser Arg Trp Pro Glu His Arg 
        115                 120                 125             


Arg Val Glu His Ile Thr Thr Asp Gly Phe Leu His Pro Asn Gln Val 
    130                 135                 140                 


Leu Lys Glu Arg Gly Leu Met Gly Lys Lys Gly Phe Pro Glu Ser Tyr 
145                 150                 155                 160 


Asp Met His Arg Leu Met Lys Phe Val Lys Asp Leu Lys Ser Gly Val 
                165                 170                 175     


Pro Asn Val Thr Ala Pro Val Tyr Ser His Leu Ile Tyr Asp Val Ile 
            180                 185                 190         


Pro Asp Gly Asp Lys Thr Val Val Gln Pro Asp Ile Leu Ile Leu Glu 
        195                 200                 205             


Gly Leu Asn Val Leu Gln Ser Gly Met Asp Tyr Pro His Asp Pro His 
    210                 215                 220                 


His Val Phe Val Ser Asp Phe Val Asp Phe Ser Ile Tyr Val Asp Ala 
225                 230                 235                 240 


Pro Glu Asp Leu Leu Gln Thr Trp Tyr Ile Asn Arg Phe Leu Lys Phe 
                245                 250                 255     


Arg Glu Gly Ala Phe Thr Asp Pro Asp Ser Tyr Phe His Gly Tyr Ala 
            260                 265                 270         


Lys Leu Thr Lys Glu Glu Ala Ile Lys Thr Ala Met Thr Ile Trp Lys 
        275                 280                 285             


Glu Met Asn His Leu Asn Leu Lys Gln Asn Ile Leu Pro Thr Arg Glu 
    290                 295                 300                 


Arg Ala Ser Leu Ile Leu Thr Lys Ser Ala Asn His Ile Val Glu Glu 
305                 310                 315                 320 


Val Arg Leu Arg Lys 
                325 


<210>  14
<211>  263
<212>  PRT
<213>  Shewanella halifaxensis

<400>  14

Met His His His His His His Cys Asp Leu Lys Lys Ala Ala Gln Arg 
1               5                   10                  15      


Ala Ile Ser Leu Met Asp Leu Thr Thr Leu Asn Asp Asp Asp Thr Asp 
            20                  25                  30          


Gln Lys Val Ile Glu Leu Cys His Lys Ala Lys Thr Pro Ala Gly Asp 
        35                  40                  45              


Thr Ala Ala Ile Val Ile Tyr Pro Arg Phe Ile Pro Ile Ala Arg Lys 
    50                  55                  60                  


Thr Leu Asn Glu Ile Gly Gly Leu Asp Ile Lys Ile Val Thr Val Thr 
65                  70                  75                  80  


Asn Phe Pro His Gly Asn Asp Asp Ile Ala Ile Ala Val Leu Glu Thr 
                85                  90                  95      


Arg Ala Ala Val Ala Tyr Gly Ala Asp Glu Val Asp Val Val Phe Pro 
            100                 105                 110         


Tyr Arg Ala Leu Met Glu Gly Asn Glu Thr Val Gly Phe Glu Leu Val 
        115                 120                 125             


Lys Ala Cys Lys Glu Ala Cys Gly Glu Asp Thr Ile Leu Lys Val Ile 
    130                 135                 140                 


Ile Glu Ser Gly Val Leu Lys Asp Pro Ala Leu Ile Arg Lys Ala Ser 
145                 150                 155                 160 


Glu Ile Ser Ile Asp Ala Gly Ala Asp Phe Ile Lys Thr Ser Thr Gly 
                165                 170                 175     


Lys Val Ala Val Asn Ala Thr Leu Glu Ala Ala Glu Ile Ile Met Thr 
            180                 185                 190         


Val Ile Ser Glu Lys Asn Pro Lys Val Gly Phe Lys Pro Ala Gly Gly 
        195                 200                 205             


Ile Lys Asp Ala Ala Ala Ala Ala Glu Phe Leu Gly Val Ala Ala Arg 
    210                 215                 220                 


Leu Leu Gly Asp Asp Trp Ala Thr Pro Ala Thr Phe Arg Phe Gly Ala 
225                 230                 235                 240 


Thr Asp Leu Leu Thr Asn Leu Leu His Thr Leu Glu Leu Ala Asp Ala 
                245                 250                 255     


Pro Gln Gly Ala Gln Gly Tyr 
            260             


<210>  15
<211>  239
<212>  PRT
<213>  Escherichia coli

<400>  15

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  16
<211>  650
<212>  PRT
<213>  Fusarium graminearum

<400>  16

Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      


Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          


Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              


Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  


Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  


Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      


Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         


Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             


Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 


Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 


Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     


Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         


Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             


Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 


His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 


Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     


Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         


Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             


Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 


Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 


Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     


Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         


Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             


Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 


Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 


Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     


Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         


Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             


Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 


Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 


Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     


His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         


Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             


Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 


Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 


Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     


Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         


Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             


Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 


Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 


Gly Gln Thr Gly His His His His His His 
                645                 650 


<210>  17
<211>  650
<212>  PRT
<213>  Fusarium graminearum

<400>  17

Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      


Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          


Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              


Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  


Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  


Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      


Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         


Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             


Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 


Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 


Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     


Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         


Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             


Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 


His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 


Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     


Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         


Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             


Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 


Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 


Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     


Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         


Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             


Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 


Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 


Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     


Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         


Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             


Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 


Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 


Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     


His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         


Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             


Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 


Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 


Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     


Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         


Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             


Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 


Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 


Gly Gln Thr Gly His His His His His His 
                645                 650 


<210>  18
<211>  650
<212>  PRT
<213>  Fusarium graminearum

<400>  18

Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      


Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          


Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              


Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  


Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  


Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      


Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         


Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             


Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 


Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 


Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     


Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         


Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             


Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 


His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 


Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     


Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         


Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             


Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 


Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 


Met Leu Thr Ala Asp Lys Arg Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     


Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         


Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             


Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 


Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 


Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     


Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         


Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             


Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 


Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 


Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     


His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         


Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             


Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 


Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 


Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     


Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         


Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             


Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 


Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 


Gly Gln Thr Gly His His His His His His 
                645                 650 


<210>  19
<211>  650
<212>  PRT
<213>  Fusarium graminearum

<400>  19

Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      


Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          


Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              


Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  


Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  


Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      


Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         


Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             


Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 


Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 


Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     


Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         


Asp Ala Phe Arg Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             


Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 


His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 


Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     


Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         


Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             


Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 


Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 


Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     


Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         


Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             


Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 


Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 


Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     


Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         


Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             


Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 


Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 


Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     


His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         


Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             


Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 


Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 


Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     


Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         


Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             


Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 


Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 


Gly Gln Thr Gly His His His His His His 
                645                 650 


<210>  20
<211>  326
<212>  PRT
<213>  Escherichia coli

<400>  20

Met His His His His His His Gly Gly Ser Gly Ser Ile Lys Glu Gln 
1               5                   10                  15      


Thr Leu Met Thr Pro Tyr Leu Gln Leu Asp Arg Asn Gln Trp Ala Ala 
            20                  25                  30          


Leu Arg Asp Ser Asn Pro Met Thr Leu Ser Glu Asp Glu Ile Ala Arg 
        35                  40                  45              


Leu Lys Gly Ile Asn Glu Asp Leu Ser Leu Glu Glu Val Ala Glu Val 
    50                  55                  60                  


Tyr Leu Pro Leu Ser Arg Leu Leu Asn Phe Tyr Ile Ser Ser Asn Leu 
65                  70                  75                  80  


Arg Arg Gln Ala Gln Leu Glu Gln Phe Leu Gly Thr Asn Gly Gln Arg 
                85                  90                  95      


Ile Pro Tyr Ile Ile Ser Ile Ala Gly Ser Val Ala Val Gly Lys Ser 
            100                 105                 110         


Thr Phe Ala Arg Val Leu Gln Ala Leu Leu Ser Arg Trp Pro Glu His 
        115                 120                 125             


Arg Arg Val Glu His Ile Thr Thr Asp Gly Phe Leu His Pro Asn Gln 
    130                 135                 140                 


Val Leu Lys Glu Arg Gly Leu Met Gly Lys Lys Gly Phe Pro Glu Ser 
145                 150                 155                 160 


Tyr Asp Met His Arg Leu Met Lys Phe Val Lys Asp Leu Lys Ser Gly 
                165                 170                 175     


Val Pro Asn Val Thr Ala Pro Val Tyr Ser His Leu Ile Tyr Asp Val 
            180                 185                 190         


Ile Pro Asp Gly Asp Lys Thr Val Val Gln Pro Asp Ile Leu Ile Leu 
        195                 200                 205             


Glu Gly Leu Asn Val Leu Gln Ser Gly Met Asp Tyr Pro His Asp Pro 
    210                 215                 220                 


His His Val Phe Val Ser Asp Phe Val Asp Phe Ser Ile Tyr Val Asp 
225                 230                 235                 240 


Ala Pro Glu Asp Leu Leu Gln Thr Trp Tyr Ile Asn Arg Phe Leu Lys 
                245                 250                 255     


Phe Arg Glu Gly Ala Phe Thr Asp Pro Asp Ser Tyr Phe His Gly Tyr 
            260                 265                 270         


Ala Lys Leu Thr Lys Glu Glu Ala Ile Lys Thr Ala Met Thr Ile Trp 
        275                 280                 285             


Lys Glu Met Asn His Val Asn Leu Lys Gln Asn Ile Leu Pro Thr Arg 
    290                 295                 300                 


Glu Arg Ala Ser Leu Ile Leu Thr Lys Ser Ala Asn His Ile Val Glu 
305                 310                 315                 320 


Glu Val Arg Leu Arg Lys 
                325     


<210>  21
<211>  413
<212>  PRT
<213>  Thermotoga maritima

<400>  21

Met Gly Ser His His His His His His Gly Ser Arg Val Leu Asn Ile 
1               5                   10                  15      


Asn Ser Gly Ser Ser Ser Ile Lys Tyr Gln Leu Ile Glu Met Glu Gly 
            20                  25                  30          


Glu Lys Val Leu Cys Lys Gly Ile Ala Glu Arg Ile Gly Ile Glu Gly 
        35                  40                  45              


Ser Arg Leu Val His Arg Val Gly Asp Glu Lys His Val Ile Glu Arg 
    50                  55                  60                  


Glu Leu Pro Asp His Glu Glu Ala Leu Lys Leu Ile Leu Asn Thr Leu 
65                  70                  75                  80  


Val Asp Glu Lys Leu Gly Val Ile Lys Asp Leu Lys Glu Ile Asp Ala 
                85                  90                  95      


Val Gly His Arg Val Val His Gly Gly Glu Arg Phe Lys Glu Ser Val 
            100                 105                 110         


Leu Val Asp Glu Glu Val Leu Lys Ala Ile Glu Glu Val Ser Pro Leu 
        115                 120                 125             


Ala Pro Leu His Asn Pro Ala Asn Leu Met Gly Ile Lys Ala Ala Met 
    130                 135                 140                 


Lys Leu Leu Pro Gly Val Pro Asn Val Gln Val Phe Asp Thr Ala Phe 
145                 150                 155                 160 


His Gln Thr Ile Pro Gln Lys Ala Tyr Leu Tyr Ala Ile Pro Tyr Glu 
                165                 170                 175     


Tyr Tyr Glu Lys Tyr Lys Ile Arg Arg Tyr Gly Phe His Gly Ile Ser 
            180                 185                 190         


His Arg Tyr Val Ser Lys Arg Ala Ala Glu Ile Leu Gly Lys Lys Leu 
        195                 200                 205             


Glu Glu Leu Lys Ile Ile Thr Cys His Ile Gly Asn Gly Ala Ser Val 
    210                 215                 220                 


Ala Ala Val Lys Tyr Gly Lys Cys Val Asp Thr Ser Met Gly Phe Thr 
225                 230                 235                 240 


Pro Leu Glu Gly Leu Val Met Gly Thr Arg Ser Gly Asp Leu Asp Pro 
                245                 250                 255     


Ala Ile Pro Phe Phe Ile Met Glu Lys Glu Gly Ile Ser Pro Gln Glu 
            260                 265                 270         


Met Tyr Asp Ile Leu Asn Lys Lys Ser Gly Val Tyr Gly Leu Ser Lys 
        275                 280                 285             


Gly Phe Ser Ser Asp Met Arg Asp Asn Leu Glu Ala Ala Leu Lys Gly 
    290                 295                 300                 


Asp Glu Trp Cys Lys Leu Val Leu Glu Ile Tyr Asp Tyr Arg Ile Ala 
305                 310                 315                 320 


Lys Tyr Ile Gly Ala Tyr Ala Ala Ala Met Asn Gly Val Asp Ala Ile 
                325                 330                 335     


Val Phe Thr Ala Gly Val Gly Glu Asn Ser Pro Ile Thr Arg Glu Asp 
            340                 345                 350         


Val Cys Lys Tyr Leu Glu Phe Leu Gly Val Lys Leu Asp Lys Gln Lys 
        355                 360                 365             


Asn Glu Glu Thr Ile Arg Gly Lys Glu Gly Ile Ile Ser Thr Pro Asp 
    370                 375                 380                 


Ser Arg Val Lys Val Leu Val Val Pro Thr Asn Glu Glu Leu Met Ile 
385                 390                 395                 400 


Ala Arg Asp Thr Lys Glu Ile Val Glu Lys Ile Gly Arg 
                405                 410             


