                         SEQUENCE LISTING

<110>  KAHR Medical Ltd.
       PECKER, Iris
       BLOCH, Itai
 
<120>  SIRPalpha-4-1BBL VARIANT FUSION PROTEIN AND METHODS OF USE 
       THEREOF

<130>  77794

<150>  US 62/696,362
<151>  2018-07-11

<160>  99    

<170>  PatentIn version 3.5

<210>  1
<211>  555
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ORIGINAL SIRPa-4-1BBL with C-terminal His Tag

<400>  1

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Gly Ala Cys Pro Trp Ala Val Ser Gly 
            340                 345                 350         


Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
        355                 360                 365             


Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln 
    370                 375                 380                 


Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
385                 390                 395                 400 


Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
                405                 410                 415     


Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
            420                 425                 430         


Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
        435                 440                 445             


Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
    450                 455                 460                 


Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
465                 470                 475                 480 


Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
                485                 490                 495     


Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His 
            500                 505                 510         


Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
        515                 520                 525             


Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro 
    530                 535                 540                 


Ser Pro Arg Ser Glu His His His His His His 
545                 550                 555 


<210>  2
<211>  343
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ORIGINAL SIRPa DOMAIN

<400>  2

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr 
            340             


<210>  3
<211>  205
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ORIGINAL 4-1BBL DOMAIN

<400>  3

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            20                  25                  30          


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        35                  40                  45              


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    50                  55                  60                  


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
65                  70                  75                  80  


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                85                  90                  95      


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            100                 105                 110         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        115                 120                 125             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    130                 135                 140                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
145                 150                 155                 160 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                165                 170                 175     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            180                 185                 190         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200                 205 


<210>  4
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SIGNAL PEPTIDE

<400>  4

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  5
<211>  549
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ORIGINAL SIRPa-4-1BBL without His Tag

<400>  5

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Gly Ala Cys Pro Trp Ala Val Ser Gly 
            340                 345                 350         


Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
        355                 360                 365             


Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln 
    370                 375                 380                 


Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
385                 390                 395                 400 


Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
                405                 410                 415     


Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
            420                 425                 430         


Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
        435                 440                 445             


Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
    450                 455                 460                 


Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
465                 470                 475                 480 


Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
                485                 490                 495     


Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His 
            500                 505                 510         


Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
        515                 520                 525             


Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro 
    530                 535                 540                 


Ser Pro Arg Ser Glu 
545                 


<210>  6
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  partial sequence of the n-terminal of 4-1BBL domain

<400>  6

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly 
1               5                   10                  


<210>  7
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  partial sequence of the n-terminal of 4-1BBL domain

<400>  7

Ala Cys Pro Trp Ala Val 
1               5       


<210>  8
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  partial sequence of the C-terminal of SIRP-alpha

<400>  8

Thr Glu Leu Ser Val Arg Ala Lys Pro Ser 
1               5                   10  


<210>  9
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  partial sequence of SIRP-alpha

<400>  9

Val Ser Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn 
1               5                   10                  15      


Thr Gly Ser Asn Glu Arg Asn Ile Tyr 
            20                  25  


<210>  10
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  partial sequence of the 4-1BB-L

<400>  10

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
            20                  25                  30  


<210>  11
<211>  543
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107_var1 without His Tag

<400>  11

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Gly Ser Gly Ala Arg Ala Ser Pro Gly 
            340                 345                 350         


Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
        355                 360                 365             


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
    370                 375                 380                 


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
385                 390                 395                 400 


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
                405                 410                 415     


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
            420                 425                 430         


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
        435                 440                 445             


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
    450                 455                 460                 


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
465                 470                 475                 480 


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
                485                 490                 495     


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
            500                 505                 510         


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
        515                 520                 525             


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
    530                 535                 540             


<210>  12
<211>  549
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107_var1 with His Tag

<400>  12

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Gly Ser Gly Ala Arg Ala Ser Pro Gly 
            340                 345                 350         


Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
        355                 360                 365             


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
    370                 375                 380                 


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
385                 390                 395                 400 


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
                405                 410                 415     


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
            420                 425                 430         


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
        435                 440                 445             


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
    450                 455                 460                 


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
465                 470                 475                 480 


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
                485                 490                 495     


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
            500                 505                 510         


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
        515                 520                 525             


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu His 
    530                 535                 540                 


His His His His His 
545                 


<210>  13
<211>  535
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107_var2 without His Tag

<400>  13

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Gly Ser Ala Ala Ser Pro Arg Leu Arg 
            340                 345                 350         


Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
        355                 360                 365             


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
    370                 375                 380                 


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
385                 390                 395                 400 


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
                405                 410                 415     


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
            420                 425                 430         


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
        435                 440                 445             


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
    450                 455                 460                 


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
465                 470                 475                 480 


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                485                 490                 495     


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
            500                 505                 510         


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
        515                 520                 525             


Leu Pro Ser Pro Arg Ser Glu 
    530                 535 


<210>  14
<211>  541
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107_var2 with His Tag

<400>  14

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Gly Ser Ala Ala Ser Pro Arg Leu Arg 
            340                 345                 350         


Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
        355                 360                 365             


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
    370                 375                 380                 


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
385                 390                 395                 400 


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
                405                 410                 415     


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
            420                 425                 430         


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
        435                 440                 445             


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
    450                 455                 460                 


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
465                 470                 475                 480 


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                485                 490                 495     


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
            500                 505                 510         


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
        515                 520                 525             


Leu Pro Ser Pro Arg Ser Glu His His His His His His 
    530                 535                 540     


<210>  15
<211>  322
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107_var3 without His Tag

<400>  15

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Gly Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala 
        115                 120                 125             


Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu 
    130                 135                 140                 


Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe 
145                 150                 155                 160 


Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser 
                165                 170                 175     


Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
            180                 185                 190         


Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
        195                 200                 205             


Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu 
    210                 215                 220                 


Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser 
225                 230                 235                 240 


Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala 
                245                 250                 255     


Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu 
            260                 265                 270         


His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala 
        275                 280                 285             


Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly 
    290                 295                 300                 


Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg 
305                 310                 315                 320 


Ser Glu 
        


<210>  16
<211>  316
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107_var3.1 without His Tag

<400>  16

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Gly Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala 
        115                 120                 125             


Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala 
    130                 135                 140                 


Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
145                 150                 155                 160 


Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
                165                 170                 175     


Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
            180                 185                 190         


Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
        195                 200                 205             


Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
    210                 215                 220                 


Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
225                 230                 235                 240 


Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
                245                 250                 255     


Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
            260                 265                 270         


Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
        275                 280                 285             


Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 
    290                 295                 300                 


Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
305                 310                 315     


<210>  17
<211>  322
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107_var3.1 with His Tag

<400>  17

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Gly Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala 
        115                 120                 125             


Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala 
    130                 135                 140                 


Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
145                 150                 155                 160 


Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
                165                 170                 175     


Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
            180                 185                 190         


Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
        195                 200                 205             


Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
    210                 215                 220                 


Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
225                 230                 235                 240 


Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
                245                 250                 255     


Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
            260                 265                 270         


Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
        275                 280                 285             


Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 
    290                 295                 300                 


Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu His His His His 
305                 310                 315                 320 


His His 
        


<210>  18
<211>  543
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107_Var1Mut without His Tag

<400>  18

Glu Glu Glu Ile Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Gly Ser Gly Ala Arg Ala Ser Pro Gly 
            340                 345                 350         


Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
        355                 360                 365             


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
    370                 375                 380                 


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
385                 390                 395                 400 


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
                405                 410                 415     


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
            420                 425                 430         


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
        435                 440                 445             


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
    450                 455                 460                 


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
465                 470                 475                 480 


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
                485                 490                 495     


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
            500                 505                 510         


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
        515                 520                 525             


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
    530                 535                 540             


<210>  19
<211>  535
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107_Var2Mut without His Tag

<400>  19

Glu Glu Glu Ile Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Gly Ser Ala Ala Ser Pro Arg Leu Arg 
            340                 345                 350         


Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
        355                 360                 365             


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
    370                 375                 380                 


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
385                 390                 395                 400 


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
                405                 410                 415     


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
            420                 425                 430         


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
        435                 440                 445             


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
    450                 455                 460                 


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
465                 470                 475                 480 


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                485                 490                 495     


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
            500                 505                 510         


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
        515                 520                 525             


Leu Pro Ser Pro Arg Ser Glu 
    530                 535 


<210>  20
<211>  322
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107_Var3Mut without His Tag

<400>  20

Glu Glu Glu Ile Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Gly Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala 
        115                 120                 125             


Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu 
    130                 135                 140                 


Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe 
145                 150                 155                 160 


Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser 
                165                 170                 175     


Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
            180                 185                 190         


Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
        195                 200                 205             


Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu 
    210                 215                 220                 


Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser 
225                 230                 235                 240 


Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala 
                245                 250                 255     


Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu 
            260                 265                 270         


His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala 
        275                 280                 285             


Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly 
    290                 295                 300                 


Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg 
305                 310                 315                 320 


Ser Glu 
        


<210>  21
<211>  315
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP170_Var3.1Mut without His tag

<400>  21

Glu Glu Glu Ile Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser 
        115                 120                 125             


Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
    130                 135                 140                 


Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn 
145                 150                 155                 160 


Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu 
                165                 170                 175     


Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
            180                 185                 190         


Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
        195                 200                 205             


Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
    210                 215                 220                 


Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu 
225                 230                 235                 240 


Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
                245                 250                 255     


Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
            260                 265                 270         


Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
        275                 280                 285             


Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
    290                 295                 300                 


Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
305                 310                 315 


<210>  22
<211>  199
<212>  PRT
<213>  Artificial sequence

<220>
<223>  199 amino acid sequence of 4-1BBL segment

<400>  22

Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg 
1               5                   10                  15      


Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
            20                  25                  30          


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
        35                  40                  45              


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
    50                  55                  60                  


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
65                  70                  75                  80  


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
                85                  90                  95      


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
            100                 105                 110         


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
        115                 120                 125             


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
    130                 135                 140                 


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
145                 150                 155                 160 


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
                165                 170                 175     


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
            180                 185                 190         


Leu Pro Ser Pro Arg Ser Glu 
        195                 


<210>  23
<211>  191
<212>  PRT
<213>  Artificial sequence

<220>
<223>  191 amino acid sequence of 4-1BBL segment

<400>  23

Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
1               5                   10                  15      


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
            20                  25                  30          


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
        35                  40                  45              


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
    50                  55                  60                  


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
65                  70                  75                  80  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
                85                  90                  95      


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
            100                 105                 110         


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
        115                 120                 125             


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
    130                 135                 140                 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
145                 150                 155                 160 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
                165                 170                 175     


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 185                 190     


<210>  24
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  116 amino acid sequence of SIRPa segment

<400>  24

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala 
        115     


<210>  25
<211>  343
<212>  PRT
<213>  Artificial sequence

<220>
<223>  343 amino acids sequence of SIRPa with 4 point mutations

<400>  25

Glu Glu Glu Ile Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr 
            340             


<210>  26
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  116 amino acids sequence of SIRPa with 4 point mutations

<400>  26

Glu Glu Glu Ile Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala 
        115     


<210>  27
<211>  197
<212>  PRT
<213>  Artificial sequence

<220>
<223>  197 amino acid sequence of 4-1BBL segment

<400>  27

Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
1               5                   10                  15      


Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln 
            20                  25                  30          


Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
        35                  40                  45              


Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
    50                  55                  60                  


Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
65                  70                  75                  80  


Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
                85                  90                  95      


Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
            100                 105                 110         


Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
        115                 120                 125             


Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
    130                 135                 140                 


Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His 
145                 150                 155                 160 


Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
                165                 170                 175     


Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro 
            180                 185                 190         


Ser Pro Arg Ser Glu 
        195         


<210>  28
<211>  185
<212>  PRT
<213>  Artificial sequence

<220>
<223>  185 amino acid sequence of 4-1BBL segment

<400>  28

Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu 
1               5                   10                  15      


Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
            20                  25                  30          


Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
        35                  40                  45              


Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
    50                  55                  60                  


Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
65                  70                  75                  80  


Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
                85                  90                  95      


His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
            100                 105                 110         


Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
        115                 120                 125             


Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
    130                 135                 140                 


Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
145                 150                 155                 160 


Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
                165                 170                 175     


Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 185 


<210>  29
<211>  504
<212>  PRT
<213>  Artificial sequence

<220>
<223>  amino acid sequence of full length SIRP

<400>  29

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
    130                 135                 140                 


Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
145                 150                 155                 160 


Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
                165                 170                 175     


Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
            180                 185                 190         


Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
        195                 200                 205             


Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
    210                 215                 220                 


Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
225                 230                 235                 240 


Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
                245                 250                 255     


Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
            260                 265                 270         


Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
        275                 280                 285             


Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
    290                 295                 300                 


Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
305                 310                 315                 320 


Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
                325                 330                 335     


Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 
            340                 345                 350         


Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 
        355                 360                 365             


Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 
    370                 375                 380                 


Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 
385                 390                 395                 400 


Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 
                405                 410                 415     


Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 
            420                 425                 430         


Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 
        435                 440                 445             


Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 
    450                 455                 460                 


Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 
465                 470                 475                 480 


Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 
                485                 490                 495     


Ala Ser Val Gln Val Pro Arg Lys 
            500                 


<210>  30
<211>  1512
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence of full length SIRP

<400>  30
atggagcccg ccggcccggc ccccggccgc ctcgggccgc tgctctgcct gctgctcgcc       60

gcgtcctgcg cctggtcagg agtggcgggt gaggaggagc tgcaggtgat tcagcctgac      120

aagtccgtat cagttgcagc tggagagtcg gccattctgc actgcactgt gacctccctg      180

atccctgtgg ggcccatcca gtggttcaga ggagctggac cagcccggga attaatctac      240

aatcaaaaag aaggccactt cccccgggta acaactgttt cagagtccac aaagagagaa      300

aacatggact tttccatcag catcagtaac atcaccccag cagatgccgg cacctactac      360

tgtgtgaagt tccggaaagg gagccctgac acggagttta agtctggagc aggcactgag      420

ctgtctgtgc gtgccaaacc ctctgccccc gtggtatcgg gccctgcggc gagggccaca      480

cctcagcaca cagtgagctt cacctgcgag tcccacggct tctcacccag agacatcacc      540

ctgaaatggt tcaaaaatgg gaatgagctc tcagacttcc agaccaacgt ggaccccgta      600

ggagagagcg tgtcctacag catccacagc acagccaagg tggtgctgac ccgcgaggac      660

gttcactctc aagtcatctg cgaggtggcc cacgtcacct tgcaggggga ccctcttcgt      720

gggactgcca acttgtctga gaccatccga gttccaccca ccttggaggt tactcaacag      780

cccgtgaggg cagagaacca ggtgaatgtc acctgccagg tgaggaagtt ctacccccag      840

agactacagc tgacctggtt ggagaatgga aacgtgtccc ggacagaaac ggcctcaacc      900

gttacagaga acaaggatgg tacctacaac tggatgagct ggctcctggt gaatgtatct      960

gcccacaggg atgatgtgaa gctcacctgc caggtggagc atgacgggca gccagcggtc     1020

agcaaaagcc atgacctgaa ggtctcagcc cacccgaagg agcagggctc aaataccgcc     1080

gctgagaaca ctggatctaa tgaacggaac atctatattg tggtgggtgt ggtgtgcacc     1140

ttgctggtgg ccctactgat ggcggccctc tacctcgtcc gaatcagaca gaagaaagcc     1200

cagggctcca cttcttctac aaggttgcat gagcccgaga agaatgccag agaaataaca     1260

caggacacaa atgatatcac atatgcagac ctgaacctgc ccaaggggaa gaagcctgct     1320

ccccaggctg cggagcccaa caaccacacg gagtatgcca gcattcagac cagcccgcag     1380

cccgcgtcgg aggacaccct cacctatgct gacctggaca tggtccacct caaccggacc     1440

cccaagcagc cggcccccaa gcctgagccg tccttctcag agtacgccag cgtccaggtc     1500

ccgaggaagt ga                                                         1512


<210>  31
<211>  1029
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 2

<400>  31
gaggaggagc tgcaggtgat tcagcctgac aagtccgtat cagttgcagc tggagagtcg       60

gccattctgc actgcactgt gacctccctg atccctgtgg ggcccatcca gtggttcaga      120

ggagctggac cagcccggga attaatctac aatcaaaaag aaggccactt cccccgggta      180

acaactgttt cagagtccac aaagagagaa aacatggact tttccatcag catcagtaac      240

atcaccccag cagatgccgg cacctactac tgtgtgaagt tccggaaagg gagccctgac      300

acggagttta agtctggagc aggcactgag ctgtctgtgc gtgccaaacc ctctgccccc      360

gtggtatcgg gccctgcggc gagggccaca cctcagcaca cagtgagctt cacctgcgag      420

tcccacggct tctcacccag agacatcacc ctgaaatggt tcaaaaatgg gaatgagctc      480

tcagacttcc agaccaacgt ggaccccgta ggagagagcg tgtcctacag catccacagc      540

acagccaagg tggtgctgac ccgcgaggac gttcactctc aagtcatctg cgaggtggcc      600

cacgtcacct tgcaggggga ccctcttcgt gggactgcca acttgtctga gaccatccga      660

gttccaccca ccttggaggt tactcaacag cccgtgaggg cagagaacca ggtgaatgtc      720

acctgccagg tgaggaagtt ctacccccag agactacagc tgacctggtt ggagaatgga      780

aacgtgtccc ggacagaaac ggcctcaacc gttacagaga acaaggatgg tacctacaac      840

tggatgagct ggctcctggt gaatgtatct gcccacaggg atgatgtgaa gctcacctgc      900

caggtggagc atgacgggca gccagcggtc agcaaaagcc atgacctgaa ggtctcagcc      960

cacccgaagg agcagggctc aaataccgcc gctgagaaca ctggatctaa tgaacggaac     1020

atctatatt                                                             1029


<210>  32
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  THE DELETED PART OF SEQ ID NO: 2 FOR GENERATION OF THE 116 AA 
       VARIANT

<400>  32

Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro 
1               5                   10                  15      


Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg 
            20                  25                  30          


Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe 
        35                  40                  45              


Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile His 
    50                  55                  60                  


Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val 
65                  70                  75                  80  


Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly 
                85                  90                  95      


Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu Val 
            100                 105                 110         


Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys Gln 
        115                 120                 125             


Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn 
    130                 135                 140                 


Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn Lys 
145                 150                 155                 160 


Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser Ala 
                165                 170                 175     


His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly Gln 
            180                 185                 190         


Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His Pro Lys 
        195                 200                 205             


Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn Glu Arg 
    210                 215                 220                 


Asn Ile Tyr 
225         


<210>  33
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 24

<400>  33
gaagaggaac tgcaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccgc cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagaga gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcgtgaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagct                   348


<210>  34
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 26

<400>  34
gaagaggaaa tccaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccat cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagagt gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcatcaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagct                   348


<210>  35
<211>  1029
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 25

<400>  35
gaagaggaaa tccaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccat cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagagt gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcatcaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagctaa accttctgct      360

cccgtggtgt ctggccctgc cgctagagct acacctcagc acaccgtgtc ttttacctgc      420

gagtcccacg gcttcagccc tagagacatc accctgaagt ggttcaagaa cggcaacgag      480

ctgtccgact tccagaccaa cgtggaccct gtgggagagt ccgtgtccta ctccatccac      540

tctaccgcca aggtggtgct gacccgagag gacgtgcaca gccaagtgat ctgtgaagtg      600

gcccacgtga ccctccaggg cgatcctttg agaggcaccg ccaacctgtc cgagacaatc      660

agagtgcctc ctacactgga agtgacccag cagcctgtgc gggccgagaa tcaagtgaac      720

gtgacctgcc aagtgcggaa gttctaccct cagagactgc agctgacctg gctggaaaac      780

ggcaatgtgt ccagaaccga gacagcctcc accgtgaccg agaacaagga tggcacctac      840

aattggatgt cctggctgct cgtgaacgtg tccgctcaca gagatgacgt gaagctgaca      900

tgccaggtgg aacacgatgg ccagcctgcc gtgtctaagt cccacgacct gaaagtgtct      960

gctcacccca aagagcaggg ctccaatacc gccgctgaga acaccggctc caacgagaga     1020

aacatctac                                                             1029


<210>  36
<211>  254
<212>  PRT
<213>  Artificial sequence

<220>
<223>  amino acid sequence of full length 4-1BBL

<400>  36

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  37
<211>  765
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence of full length 4-1BBL

<400>  37
atggaatacg cctctgacgc ttcactggac cccgaagccc cgtggcctcc cgcgccccgc       60

gctcgcgcct gccgcgtact gccttgggcc ctggtcgcgg ggctgctgct gctgctgctg      120

ctcgctgccg cctgcgccgt cttcctcgcc tgcccctggg ccgtgtccgg ggctcgcgcc      180

tcgcccggct ccgcggccag cccgagactc cgcgagggtc ccgagctttc gcccgacgat      240

cccgccggcc tcttggacct gcggcagggc atgtttgcgc agctggtggc ccaaaatgtt      300

ctgctgatcg atgggcccct gagctggtac agtgacccag gcctggcagg cgtgtccctg      360

acggggggcc tgagctacaa agaggacacg aaggagctgg tggtggccaa ggctggagtc      420

tactatgtct tctttcaact agagctgcgg cgcgtggtgg ccggcgaggg ctcaggctcc      480

gtttcacttg cgctgcacct gcagccactg cgctctgctg ctggggccgc cgccctggct      540

ttgaccgtgg acctgccacc cgcctcctcc gaggctcgga actcggcctt cggtttccag      600

ggccgcttgc tgcacctgag tgccggccag cgcctgggcg tccatcttca cactgaggcc      660

agggcacgcc atgcctggca gcttacccag ggcgccacag tcttgggact cttccgggtg      720

acccccgaaa tcccagccgg actcccttca ccgaggtcgg aataa                      765


<210>  38
<211>  615
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 3

<400>  38
gcctgcccct gggccgtgtc cggggctcgc gcctcgcccg gctccgcggc cagcccgaga       60

ctccgcgagg gtcccgagct ttcgcccgac gatcccgccg gcctcttgga cctgcggcag      120

ggcatgtttg cgcagctggt ggcccaaaat gttctgctga tcgatgggcc cctgagctgg      180

tacagtgacc caggcctggc aggcgtgtcc ctgacggggg gcctgagcta caaagaggac      240

acgaaggagc tggtggtggc caaggctgga gtctactatg tcttctttca actagagctg      300

cggcgcgtgg tggccggcga gggctcaggc tccgtttcac ttgcgctgca cctgcagcca      360

ctgcgctctg ctgctggggc cgccgccctg gctttgaccg tggacctgcc acccgcctcc      420

tccgaggctc ggaactcggc cttcggtttc cagggccgct tgctgcacct gagtgccggc      480

cagcgcctgg gcgtccatct tcacactgag gccagggcac gccatgcctg gcagcttacc      540

cagggcgcca cagtcttggg actcttccgg gtgacccccg aaatcccagc cggactccct      600

tcaccgaggt cggaa                                                       615


<210>  39
<211>  624
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 22

<400>  39
atctacggcg cctgtccttg ggctgtgtct ggcgctagag catctcctgg ctctgctgcc       60

tctcctagac tgagagaggg acctgagctg tctcctgatg atcctgctgg cctgctggat      120

ctgagacagg gcatgtttgc tcagctggtg gcccagaacg tgctgctgat tgatggccct      180

ctgtcctggt actctgatcc tggattggct ggcgtgtccc tgactggcgg cctgtcttac      240

aaagaggaca ccaaagaact ggtggtggcc aaggccggcg tgtactacgt gttctttcag      300

ctggaactgc ggagagtggt ggccggcgaa ggatctggat ctgtgtctct ggcactgcat      360

ctgcagcccc tgagatctgc tgcaggcgct gctgctctgg ctctgacagt tgatctgcct      420

cctgcctcct ccgaggccag aaactccgcc tttggcttcc aaggcagact gctgcatctg      480

tctgccggcc agagactggg agtccatctg catacagagg ctagagccag gcacgcctgg      540

cagttgacac aaggtgctac agtgctgggc ctgttcagag tgaccccaga gattccagcc      600

ggcctgcctt ctccaagatc cgag                                             624


<210>  40
<211>  573
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 23

<400>  40
tctgctgcct ctcctagact gagagaggga cctgagctgt ctcctgatga tcctgctggc       60

ctgctggatc tgagacaggg catgtttgct cagctggtgg cccagaacgt gctgctgatt      120

gatggccctc tgtcctggta ctctgatcct ggattggctg gcgtgtccct gactggcggc      180

ctgtcttaca aagaggacac caaagaactg gtggtggcca aggccggcgt gtactacgtg      240

ttctttcagc tggaactgcg gagagtggtg gccggcgaag gatctggatc tgtgtctctg      300

gcactgcatc tgcagcccct gagatctgct gcaggcgctg ctgctctggc tctgacagtt      360

gatctgcctc ctgcctcctc cgaggccaga aactccgcct ttggcttcca aggcagactg      420

ctgcatctgt ctgccggcca gagactggga gtccatctgc atacagaggc tagagccagg      480

cacgcctggc agttgacaca aggtgctaca gtgctgggcc tgttcagagt gaccccagag      540

attccagccg gcctgccttc tccaagatcc gag                                   573


<210>  41
<211>  591
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 27

<400>  41
gctagagcat ctcctggctc tgctgcctct cctagactga gagagggacc tgagctgtct       60

cctgatgatc ctgctggcct gctggatctg agacagggca tgtttgctca gctggtggcc      120

cagaacgtgc tgctgattga tggccctctg tcctggtact ctgatcctgg attggctggc      180

gtgtccctga ctggcggcct gtcttacaaa gaggacacca aagaactggt ggtggccaag      240

gccggcgtgt actacgtgtt ctttcagctg gaactgcgga gagtggtggc cggcgaagga      300

tctggatctg tgtctctggc actgcatctg cagcccctga gatctgctgc aggcgctgct      360

gctctggctc tgacagttga tctgcctcct gcctcctccg aggccagaaa ctccgccttt      420

ggcttccaag gcagactgct gcatctgtct gccggccaga gactgggagt ccatctgcat      480

acagaggcta gagccaggca cgcctggcag ttgacacaag gtgctacagt gctgggcctg      540

ttcagagtga ccccagagat tccagccggc ctgccttctc caagatccga g               591


<210>  42
<211>  555
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 28

<400>  42
ctgagagagg gacctgagct gtctcctgat gatcctgctg gcctgctgga tctgagacag       60

ggcatgtttg ctcagctggt ggcccagaac gtgctgctga ttgatggccc tctgtcctgg      120

tactctgatc ctggattggc tggcgtgtcc ctgactggcg gcctgtctta caaagaggac      180

accaaagaac tggtggtggc caaggccggc gtgtactacg tgttctttca gctggaactg      240

cggagagtgg tggccggcga aggatctgga tctgtgtctc tggcactgca tctgcagccc      300

ctgagatctg ctgcaggcgc tgctgctctg gctctgacag ttgatctgcc tcctgcctcc      360

tccgaggcca gaaactccgc ctttggcttc caaggcagac tgctgcatct gtctgccggc      420

cagagactgg gagtccatct gcatacagag gctagagcca ggcacgcctg gcagttgaca      480

caaggtgcta cagtgctggg cctgttcaga gtgaccccag agattccagc cggcctgcct      540

tctccaagat ccgag                                                       555


<210>  43
<211>  574
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ORIGINAL SIRPa-4-1BBL with signal peptide and C-term His Tag

<400>  43

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val 
            20                  25                  30          


Leu Val Ala Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser 
        35                  40                  45              


Leu Ile Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly 
    50                  55                  60                  


Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr 
65                  70                  75                  80  


Thr Val Ser Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg 
                85                  90                  95      


Ile Gly Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys 
            100                 105                 110         


Phe Arg Lys Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly 
        115                 120                 125             


Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly 
    130                 135                 140                 


Pro Ala Ala Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu 
145                 150                 155                 160 


Ser His Gly Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn 
                165                 170                 175     


Gly Asn Glu Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu 
            180                 185                 190         


Ser Val Ser Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg 
        195                 200                 205             


Glu Asp Val His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu 
    210                 215                 220                 


Gln Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg 
225                 230                 235                 240 


Val Pro Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn 
                245                 250                 255     


Gln Val Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu 
            260                 265                 270         


Gln Leu Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala 
        275                 280                 285             


Ser Thr Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp 
    290                 295                 300                 


Leu Leu Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys 
305                 310                 315                 320 


Gln Val Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu 
                325                 330                 335     


Lys Val Ser Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu 
            340                 345                 350         


Asn Thr Gly Ser Asn Glu Arg Asn Ile Tyr Gly Ala Cys Pro Trp Ala 
        355                 360                 365             


Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu 
    370                 375                 380                 


Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
385                 390                 395                 400 


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
                405                 410                 415     


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
            420                 425                 430         


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
        435                 440                 445             


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
    450                 455                 460                 


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
465                 470                 475                 480 


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
                485                 490                 495     


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
            500                 505                 510         


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
        515                 520                 525             


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
    530                 535                 540                 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
545                 550                 555                 560 


Gly Leu Pro Ser Pro Arg Ser Glu His His His His His His 
                565                 570                 


<210>  44
<211>  555
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ORIGINAL SIRPa-4-1BBL with signal peptide and  N-terminal His Tag

<400>  44

His His His His His His Glu Glu Glu Leu Gln Val Ile Gln Pro Asp 
1               5                   10                  15      


Lys Ser Val Leu Val Ala Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr 
            20                  25                  30          


Ala Thr Ser Leu Ile Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala 
        35                  40                  45              


Gly Pro Gly Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro 
    50                  55                  60                  


Arg Val Thr Thr Val Ser Asp Leu Thr Lys Arg Asn Asn Met Asp Phe 
65                  70                  75                  80  


Ser Ile Arg Ile Gly Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr 
                85                  90                  95      


Cys Val Lys Phe Arg Lys Gly Ser Pro Asp Asp Val Glu Phe Lys Ser 
            100                 105                 110         


Gly Ala Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Ala Pro Val 
        115                 120                 125             


Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln His Thr Val Ser Phe 
    130                 135                 140                 


Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp 
145                 150                 155                 160 


Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln Thr Asn Val Asp Pro 
                165                 170                 175     


Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser Thr Ala Lys Val Val 
            180                 185                 190         


Leu Thr Arg Glu Asp Val His Ser Gln Val Ile Cys Glu Val Ala His 
        195                 200                 205             


Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu 
    210                 215                 220                 


Thr Ile Arg Val Pro Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg 
225                 230                 235                 240 


Ala Glu Asn Gln Val Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro 
                245                 250                 255     


Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr 
            260                 265                 270         


Glu Thr Ala Ser Thr Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp 
        275                 280                 285             


Met Ser Trp Leu Leu Val Asn Val Ser Ala His Arg Asp Asp Val Lys 
    290                 295                 300                 


Leu Thr Cys Gln Val Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser 
305                 310                 315                 320 


His Asp Leu Lys Val Ser Ala His Pro Lys Glu Gln Gly Ser Asn Thr 
                325                 330                 335     


Ala Ala Glu Asn Thr Gly Ser Asn Glu Arg Asn Ile Tyr Gly Ala Cys 
            340                 345                 350         


Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser 
        355                 360                 365             


Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
    370                 375                 380                 


Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn 
385                 390                 395                 400 


Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu 
                405                 410                 415     


Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
            420                 425                 430         


Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
        435                 440                 445             


Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
    450                 455                 460                 


Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu 
465                 470                 475                 480 


Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
                485                 490                 495     


Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
            500                 505                 510         


Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
        515                 520                 525             


Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
    530                 535                 540                 


Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
545                 550                 555 


<210>  45
<211>  541
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107 Var. 4 [SIRP SEQ ID NO: 2 (343 amino acids), glycine 
       linker, 4-1BBL SEQ ID NO: 27 (197 aa)]

<400>  45

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Gly Ala Arg Ala Ser Pro Gly Ser Ala 
            340                 345                 350         


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
        355                 360                 365             


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
    370                 375                 380                 


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
385                 390                 395                 400 


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
                405                 410                 415     


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
            420                 425                 430         


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
        435                 440                 445             


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
    450                 455                 460                 


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
465                 470                 475                 480 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
                485                 490                 495     


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
            500                 505                 510         


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
        515                 520                 525             


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
    530                 535                 540     


<210>  46
<211>  529
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107 Var. 5: SIRP SEQ ID NO: 2 (343 amino acids), glycine 
       linker, 4-1BBL SEQ ID NO: 28 (185 aa)

<400>  46

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Gly Leu Arg Glu Gly Pro Glu Leu Ser 
            340                 345                 350         


Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
        355                 360                 365             


Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
    370                 375                 380                 


Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
385                 390                 395                 400 


Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
                405                 410                 415     


Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly 
            420                 425                 430         


Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
        435                 440                 445             


Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 
    450                 455                 460                 


Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His 
465                 470                 475                 480 


Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
                485                 490                 495     


Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
            500                 505                 510         


Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser 
        515                 520                 525             


Glu 
    


<210>  47
<211>  308
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107 Var 6: SIRP SEQ ID NO: 24 (116 amino acids), glycine 
       linker, 4-1BBL SEQ ID NO: 23 (191 amino acids):]

<400>  47

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro 
        115                 120                 125             


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
    130                 135                 140                 


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
145                 150                 155                 160 


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
                165                 170                 175     


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
            180                 185                 190         


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
        195                 200                 205             


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
    210                 215                 220                 


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
225                 230                 235                 240 


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
                245                 250                 255     


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
            260                 265                 270         


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
        275                 280                 285             


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser 
    290                 295                 300                 


Pro Arg Ser Glu 
305             


<210>  48
<211>  314
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Var 7: SIRP SEQ ID NO: 24 (116 amino acids), glycine linker, 
       4-1BBL SEQ ID NO: 27 (197 aa)

<400>  48

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro 
        115                 120                 125             


Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
    130                 135                 140                 


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
145                 150                 155                 160 


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
                165                 170                 175     


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
            180                 185                 190         


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
        195                 200                 205             


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
    210                 215                 220                 


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
225                 230                 235                 240 


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
                245                 250                 255     


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
            260                 265                 270         


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
        275                 280                 285             


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
    290                 295                 300                 


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
305                 310                 


<210>  49
<211>  302
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107 Var 8: SIRP SEQ ID NO: 24 (116 amino acids), glycine 
       linker, 4-1BBL SEQ ID NO: 28 (185 aa)

<400>  49

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Gly Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
        115                 120                 125             


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
    130                 135                 140                 


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
145                 150                 155                 160 


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
                165                 170                 175     


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
            180                 185                 190         


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
        195                 200                 205             


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
    210                 215                 220                 


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
225                 230                 235                 240 


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
                245                 250                 255     


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
            260                 265                 270         


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
        275                 280                 285             


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
    290                 295                 300         


<210>  50
<211>  1722
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 44

<400>  50
atgggctggt cctgcatcat cctgtttctg gtggctaccg ctaccggcgt gcactcccac       60

caccaccatc accacgaaga ggaactgcaa gtgatccagc ctgacaagtc cgtgctggtg      120

gctgctggcg aaaccgccac actgagatgt accgccacct ctctgatccc tgtgggccct      180

atccagtggt ttagaggcgc tggacctggc agagagctga tctacaacca gaaagagggc      240

cactttccta gagtgaccac cgtgtccgac ctgaccaagc ggaacaacat ggacttctcc      300

atccggatcg gcaacatcac ccctgctgat gccggcacct actactgcgt gaagttccgg      360

aagggctccc ctgacgacgt cgagtttaaa tccggcgctg gcaccgaact gtccgtgcga      420

gctaaacctt ctgctcccgt ggtgtctggc cctgccgcta gagctacacc tcagcacacc      480

gtgtctttta cctgcgagtc ccacggcttc agccctagag acatcaccct gaagtggttc      540

aagaacggca acgagctgtc cgacttccag accaacgtgg accctgtggg agagtccgtg      600

tcctactcca tccactctac cgccaaggtg gtgctgaccc gagaggacgt gcacagccaa      660

gtgatctgtg aagtggccca cgtgaccctc cagggcgatc ctttgagagg caccgccaac      720

ctgtccgaga caatcagagt gcctcctaca ctggaagtga cccagcagcc tgtgcgggcc      780

gagaatcaag tgaacgtgac ctgccaagtg cggaagttct accctcagag actgcagctg      840

acctggctgg aaaacggcaa tgtgtccaga accgagacag cctccaccgt gaccgagaac      900

aaggatggca cctacaattg gatgtcctgg ctgctcgtga acgtgtccgc tcacagagat      960

gacgtgaagc tgacatgcca ggtggaacac gatggccagc ctgccgtgtc taagtcccac     1020

gacctgaaag tgtctgctca ccccaaagag cagggctcca ataccgccgc tgagaacacc     1080

ggctccaacg agagaaacat ctacggcgcc tgtccttggg ctgtgtctgg cgctagagca     1140

tctcctggct ctgctgcctc tcctagactg agagagggac ctgagctgtc tcctgatgat     1200

cctgctggcc tgctggatct gagacagggc atgtttgctc agctggtggc ccagaacgtg     1260

ctgctgattg atggccctct gtcctggtac tctgatcctg gattggctgg cgtgtccctg     1320

actggcggcc tgtcttacaa agaggacacc aaagaactgg tggtggccaa ggccggcgtg     1380

tactacgtgt tctttcagct ggaactgcgg agagtggtgg ccggcgaagg atctggatct     1440

gtgtctctgg cactgcatct gcagcccctg agatctgctg caggcgctgc tgctctggct     1500

ctgacagttg atctgcctcc tgcctcctcc gaggccagaa actccgcctt tggcttccaa     1560

ggcagactgc tgcatctgtc tgccggccag agactgggag tccatctgca tacagaggct     1620

agagccaggc acgcctggca gttgacacaa ggtgctacag tgctgggcct gttcagagtg     1680

accccagaga ttccagccgg cctgccttct ccaagatccg ag                        1722


<210>  51
<211>  1749
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cloned sequence of the C-terminal his-tagged (CH)-DSP-107

<400>  51
gaattcccgc cgccaccatg ggctggtcct gcatcatcct gtttctggtg gctaccgcta       60

ccggcgtgca ctccgaagag gaactgcaag tgatccagcc tgacaagtcc gtgctggtgg      120

ctgctggcga aaccgccaca ctgagatgta ccgccacctc tctgatccct gtgggcccta      180

tccagtggtt tagaggcgct ggacctggca gagagctgat ctacaaccag aaagagggcc      240

actttcctag agtgaccacc gtgtccgacc tgaccaagcg gaacaacatg gacttctcca      300

tccggatcgg caacatcacc cctgctgatg ccggcaccta ctactgcgtg aagttccgga      360

agggctcccc tgacgacgtc gagtttaaat ccggcgctgg caccgaactg tccgtgcgag      420

ctaaaccttc tgctcccgtg gtgtctggcc ctgccgctag agctacacct cagcacaccg      480

tgtcttttac ctgcgagtcc cacggcttca gccctagaga catcaccctg aagtggttca      540

agaacggcaa cgagctgtcc gacttccaga ccaacgtgga ccctgtggga gagtccgtgt      600

cctactccat ccactctacc gccaaggtgg tgctgacccg agaggacgtg cacagccaag      660

tgatctgtga agtggcccac gtgaccctcc agggcgatcc tttgagaggc accgccaacc      720

tgtccgagac aatcagagtg cctcctacac tggaagtgac ccagcagcct gtgcgggccg      780

agaatcaagt gaacgtgacc tgccaagtgc ggaagttcta ccctcagaga ctgcagctga      840

cctggctgga aaacggcaat gtgtccagaa ccgagacagc ctccaccgtg accgagaaca      900

aggatggcac ctacaattgg atgtcctggc tgctcgtgaa cgtgtccgct cacagagatg      960

acgtgaagct gacatgccag gtggaacacg atggccagcc tgccgtgtct aagtcccacg     1020

acctgaaagt gtctgctcac cccaaagagc agggctccaa taccgccgct gagaacaccg     1080

gctccaacga gagaaacatc tacggcgcct gtccttgggc tgtgtctggc gctagagcat     1140

ctcctggctc tgctgcctct cctagactga gagagggacc tgagctgtct cctgatgatc     1200

ctgctggcct gctggatctg agacagggca tgtttgctca gctggtggcc cagaacgtgc     1260

tgctgattga tggccctctg tcctggtact ctgatcctgg attggctggc gtgtccctga     1320

ctggcggcct gtcttacaaa gaggacacca aagaactggt ggtggccaag gccggcgtgt     1380

actacgtgtt ctttcagctg gaactgcgga gagtggtggc cggcgaagga tctggatctg     1440

tgtctctggc actgcatctg cagcccctga gatctgctgc aggcgctgct gctctggctc     1500

tgacagttga tctgcctcct gcctcctccg aggccagaaa ctccgccttt ggcttccaag     1560

gcagactgct gcatctgtct gccggccaga gactgggagt ccatctgcat acagaggcta     1620

gagccaggca cgcctggcag ttgacacaag gtgctacagt gctgggcctg ttcagagtga     1680

ccccagagat tccagccggc ctgccttctc caagatccga gcaccaccac catcaccact     1740

gataagctt                                                             1749


<210>  52
<211>  1731
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cloned sequence of the C-terminal his-tagged (CH)-V1 DSP-107

<400>  52
gaattcccgc cgccaccatg ggctggtcct gcatcatcct gtttctggtg gctaccgcta       60

ccggcgtgca ctccgaagag gaactgcaag tgatccagcc tgacaagtcc gtgctggtgg      120

ctgctggcga aaccgccaca ctgagatgta ccgccacctc tctgatccct gtgggcccta      180

tccagtggtt tagaggcgct ggacctggca gagagctgat ctacaaccag aaagagggcc      240

actttcctag agtgaccacc gtgtccgacc tgaccaagcg gaacaacatg gacttctcca      300

tccggatcgg caacatcacc cctgctgatg ccggcaccta ctactgcgtg aagttccgga      360

agggctcccc tgacgacgtc gagtttaaat ccggcgctgg caccgaactg tccgtgcgag      420

ctaaaccttc tgctcccgtg gtgtctggcc ctgccgctag agctacacct cagcacaccg      480

tgtcttttac ctgcgagtcc cacggcttca gccctagaga catcaccctg aagtggttca      540

agaacggcaa cgagctgtcc gacttccaga ccaacgtgga ccctgtggga gagtccgtgt      600

cctactccat ccactctacc gccaaggtgg tgctgacccg agaggacgtg cacagccaag      660

tgatctgtga agtggcccac gtgaccctcc agggcgatcc tttgagaggc accgccaacc      720

tgtccgagac aatcagagtg cctcctacac tggaagtgac ccagcagcct gtgcgggccg      780

agaatcaagt gaacgtgacc tgccaagtgc ggaagttcta ccctcagaga ctgcagctga      840

cctggctgga aaacggcaat gtgtccagaa ccgagacagc ctccaccgtg accgagaaca      900

aggatggcac ctacaattgg atgtcctggc tgctcgtgaa cgtgtccgct cacagagatg      960

acgtgaagct gacatgccag gtggaacacg atggccagcc tgccgtgtct aagtcccacg     1020

acctgaaagt gtctgctcac cccaaagagc agggctccaa taccgccgct gagaacaccg     1080

gctccaacga gagaaacatc tacggctctg gcgctagggc ctctcctgga tctgctgctt     1140

ctcccagact gagagagggc cctgagctgt ctcctgatga tcctgctgga ctgctggatc     1200

tgagacaggg catgtttgct cagctggtgg cccagaacgt gctgctgatt gatggccctc     1260

tgtcctggta ctctgatcct ggattggctg gcgtgtccct gactggcggc ctgtcttaca     1320

aagaggacac caaagaactg gtggtggcca aggccggcgt gtactacgtg ttctttcagc     1380

tggaactgcg gagagtggtg gccggcgaag gatctggatc tgtgtctctg gctctgcatc     1440

tgcagcccct gagatctgca gcaggcgctg cagctctggc actgacagtt gatctgcctc     1500

ctgcctcctc cgaggccaga aactccgcct ttggcttcca aggcagactg ctgcacctgt     1560

ctgctggaca gagactggga gtgcacctcc acacagaggc cagagctaga catgcctggc     1620

agttgacaca gggcgctaca gtgctgggcc tgttcagagt gacacctgag attccagccg     1680

gcctgccttc tccaagatcc gagcaccacc accatcacca ctgataagct t              1731


<210>  53
<211>  1707
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cloned sequence of  the C-terminal his-tagged (CH)-V2 DSP-107

<400>  53
gaattcccgc cgccaccatg ggctggtcct gcatcatcct gtttctggtg gctaccgcta       60

ccggcgtgca ctccgaagag gaactgcaag tgatccagcc tgacaagtcc gtgctggtgg      120

ctgctggcga aaccgccaca ctgagatgta ccgccacctc tctgatccct gtgggcccta      180

tccagtggtt tagaggcgct ggacctggca gagagctgat ctacaaccag aaagagggcc      240

actttcctag agtgaccacc gtgtccgacc tgaccaagcg gaacaacatg gacttctcca      300

tccggatcgg caacatcacc cctgctgatg ccggcaccta ctactgcgtg aagttccgga      360

agggctcccc tgacgacgtc gagtttaaat ccggcgctgg caccgaactg tccgtgcgag      420

ctaaaccttc tgctcccgtg gtgtctggcc ctgccgctag agctacacct cagcacaccg      480

tgtcttttac ctgcgagtcc cacggcttca gccctagaga catcaccctg aagtggttca      540

agaacggcaa cgagctgtcc gacttccaga ccaacgtgga ccctgtggga gagtccgtgt      600

cctactccat ccactctacc gccaaggtgg tgctgacccg agaggacgtg cacagccaag      660

tgatctgtga agtggcccac gtgaccctcc agggcgatcc tttgagaggc accgccaacc      720

tgtccgagac aatcagagtg cctcctacac tggaagtgac ccagcagcct gtgcgggccg      780

agaatcaagt gaacgtgacc tgccaagtgc ggaagttcta ccctcagaga ctgcagctga      840

cctggctgga aaacggcaat gtgtccagaa ccgagacagc ctccaccgtg accgagaaca      900

aggatggcac ctacaattgg atgtcctggc tgctcgtgaa cgtgtccgct cacagagatg      960

acgtgaagct gacatgccag gtggaacacg atggccagcc tgccgtgtct aagtcccacg     1020

acctgaaagt gtctgctcac cccaaagagc agggctccaa taccgccgct gagaacaccg     1080

gctccaacga gagaaacatc tacggctctg ccgcctctcc tagactgaga gagggacctg     1140

agctgtctcc tgatgatcct gctggcctgc tggatctgag acagggcatg tttgctcagc     1200

tggtggccca gaacgtgctg ctgattgatg gccctctgtc ctggtactct gatcctggat     1260

tggctggcgt gtccctgact ggcggcctgt cttacaaaga ggacaccaaa gaactggtgg     1320

tggccaaggc cggcgtgtac tacgtgttct ttcagctgga actgcggaga gtggtggccg     1380

gcgaaggatc tggatctgtg tctctggctc tgcatctgca gcccctgaga tctgctgcag     1440

gcgctgctgc tctggcactg acagttgatc tgcctcctgc ctcctccgag gccagaaact     1500

ccgcctttgg cttccaaggc agactgctgc atctgtctgc cggccagaga ctgggagtcc     1560

atctgcatac agaggccaga gctagacacg cttggcagtt gacacagggc gctacagtgc     1620

tgggcctgtt cagagtgaca cctgagatcc cagccggcct gccttctcca agatctgagc     1680

accaccacca tcaccactga taagctt                                         1707


<210>  54
<211>  1047
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cloned sequence of  the C-terminal his-tagged (CH)-V3.1 DSP-107

<400>  54
gaattcccgc cgccaccatg ggctggtcct gcatcatcct gtttctggtg gctaccgcta       60

ccggcgtgca ctccgaagag gaactgcaag tgatccagcc tgacaagtcc gtgctggtgg      120

ctgctggcga aaccgccaca ctgagatgta ccgccacctc tctgatccct gtgggcccta      180

tccagtggtt tagaggcgct ggacctggca gagagctgat ctacaaccag aaagagggcc      240

actttcctag agtgaccacc gtgtccgacc tgaccaagcg gaacaacatg gacttctcca      300

tccggatcgg caacatcacc cctgctgatg ccggcaccta ctactgcgtg aagttccgga      360

agggctcccc tgacgacgtc gagtttaaat ccggcgctgg caccgagctg tccgtcagag      420

cttctggtgc tagagcctct cctggctctg ccgcttctcc tagactgaga gagggacctg      480

agctgtctcc tgatgatcct gctggcctgc tggatctgag acagggcatg tttgctcagc      540

tggtggccca gaacgtgctg ctgattgatg gccctctgtc ctggtactct gatcctggat      600

tggctggcgt gtccctgact ggcggcctgt cttacaaaga ggacaccaaa gaactggtgg      660

tggccaaggc cggcgtgtac tacgtgttct ttcagctgga actgcggaga gtggtggccg      720

gcgaaggatc tggatctgtg tctctggcac tgcatctgca gcctctgaga tctgctgcag      780

gcgctgctgc tctggctctg acagttgatc tgcctcctgc ctcctccgag gccagaaact      840

ccgcctttgg cttccaaggc agactgctgc atctgtctgc cggccagaga ctgggagtcc      900

atctgcatac agaggccaga gctagacacg cttggcagtt gacacagggc gctacagtgc      960

tgggcctgtt cagagtgaca cctgagatcc cagccggcct gccttctcca agatctgagc     1020

accaccacca tcaccactga taagctt                                         1047


<210>  55
<211>  1629
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 11 (DSP107_var1 without
       His Tag

<400>  55
gaagaggaac tgcaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccgc cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagaga gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcgtgaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagctaa accttctgct      360

cccgtggtgt ctggccctgc cgctagagct acacctcagc acaccgtgtc ttttacctgc      420

gagtcccacg gcttcagccc tagagacatc accctgaagt ggttcaagaa cggcaacgag      480

ctgtccgact tccagaccaa cgtggaccct gtgggagagt ccgtgtccta ctccatccac      540

tctaccgcca aggtggtgct gacccgagag gacgtgcaca gccaagtgat ctgtgaagtg      600

gcccacgtga ccctccaggg cgatcctttg agaggcaccg ccaacctgtc cgagacaatc      660

agagtgcctc ctacactgga agtgacccag cagcctgtgc gggccgagaa tcaagtgaac      720

gtgacctgcc aagtgcggaa gttctaccct cagagactgc agctgacctg gctggaaaac      780

ggcaatgtgt ccagaaccga gacagcctcc accgtgaccg agaacaagga tggcacctac      840

aattggatgt cctggctgct cgtgaacgtg tccgctcaca gagatgacgt gaagctgaca      900

tgccaggtgg aacacgatgg ccagcctgcc gtgtctaagt cccacgacct gaaagtgtct      960

gctcacccca aagagcaggg ctccaatacc gccgctgaga acaccggctc caacgagaga     1020

aacatctacg gctctggcgc tagggcctct cctggatctg ctgcttctcc cagactgaga     1080

gagggccctg agctgtctcc tgatgatcct gctggactgc tggatctgag acagggcatg     1140

tttgctcagc tggtggccca gaacgtgctg ctgattgatg gccctctgtc ctggtactct     1200

gatcctggat tggctggcgt gtccctgact ggcggcctgt cttacaaaga ggacaccaaa     1260

gaactggtgg tggccaaggc cggcgtgtac tacgtgttct ttcagctgga actgcggaga     1320

gtggtggccg gcgaaggatc tggatctgtg tctctggctc tgcatctgca gcccctgaga     1380

tctgcagcag gcgctgcagc tctggcactg acagttgatc tgcctcctgc ctcctccgag     1440

gccagaaact ccgcctttgg cttccaaggc agactgctgc acctgtctgc tggacagaga     1500

ctgggagtgc acctccacac agaggccaga gctagacatg cctggcagtt gacacagggc     1560

gctacagtgc tgggcctgtt cagagtgaca cctgagattc cagccggcct gccttctcca     1620

agatccgag                                                             1629


<210>  56
<211>  1605
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 13 (DSP107_var2 without
       His Tag)

<400>  56
gaagaggaac tgcaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccgc cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagaga gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcgtgaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagctaa accttctgct      360

cccgtggtgt ctggccctgc cgctagagct acacctcagc acaccgtgtc ttttacctgc      420

gagtcccacg gcttcagccc tagagacatc accctgaagt ggttcaagaa cggcaacgag      480

ctgtccgact tccagaccaa cgtggaccct gtgggagagt ccgtgtccta ctccatccac      540

tctaccgcca aggtggtgct gacccgagag gacgtgcaca gccaagtgat ctgtgaagtg      600

gcccacgtga ccctccaggg cgatcctttg agaggcaccg ccaacctgtc cgagacaatc      660

agagtgcctc ctacactgga agtgacccag cagcctgtgc gggccgagaa tcaagtgaac      720

gtgacctgcc aagtgcggaa gttctaccct cagagactgc agctgacctg gctggaaaac      780

ggcaatgtgt ccagaaccga gacagcctcc accgtgaccg agaacaagga tggcacctac      840

aattggatgt cctggctgct cgtgaacgtg tccgctcaca gagatgacgt gaagctgaca      900

tgccaggtgg aacacgatgg ccagcctgcc gtgtctaagt cccacgacct gaaagtgtct      960

gctcacccca aagagcaggg ctccaatacc gccgctgaga acaccggctc caacgagaga     1020

aacatctacg gctctgccgc ctctcctaga ctgagagagg gacctgagct gtctcctgat     1080

gatcctgctg gcctgctgga tctgagacag ggcatgtttg ctcagctggt ggcccagaac     1140

gtgctgctga ttgatggccc tctgtcctgg tactctgatc ctggattggc tggcgtgtcc     1200

ctgactggcg gcctgtctta caaagaggac accaaagaac tggtggtggc caaggccggc     1260

gtgtactacg tgttctttca gctggaactg cggagagtgg tggccggcga aggatctgga     1320

tctgtgtctc tggctctgca tctgcagccc ctgagatctg ctgcaggcgc tgctgctctg     1380

gcactgacag ttgatctgcc tcctgcctcc tccgaggcca gaaactccgc ctttggcttc     1440

caaggcagac tgctgcatct gtctgccggc cagagactgg gagtccatct gcatacagag     1500

gccagagcta gacacgcttg gcagttgaca cagggcgcta cagtgctggg cctgttcaga     1560

gtgacacctg agatcccagc cggcctgcct tctccaagat ctgag                     1605


<210>  57
<211>  966
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 15 (DSP107_var3 without
       His Tag)

<400>  57
gaagaggaac tgcaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccgc cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagaga gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcgtgaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagctgg cgcctgtcct      360

tgggctgtgt ctggcgctag agcatctcct ggctctgctg cctctcctag actgagagag      420

ggacctgagc tgtctcctga tgatcctgct ggcctgctgg atctgagaca gggcatgttt      480

gctcagctgg tggcccagaa cgtgctgctg attgatggcc ctctgtcctg gtactctgat      540

cctggattgg ctggcgtgtc cctgactggc ggcctgtctt acaaagagga caccaaagaa      600

ctggtggtgg ccaaggccgg cgtgtactac gtgttctttc agctggaact gcggagagtg      660

gtggccggcg aaggatctgg atctgtgtct ctggcactgc atctgcagcc cctgagatct      720

gctgcaggcg ctgctgctct ggctctgaca gttgatctgc ctcctgcctc ctccgaggcc      780

agaaactccg cctttggctt ccaaggcaga ctgctgcatc tgtctgccgg ccagagactg      840

ggagtccatc tgcatacaga ggctagagcc aggcacgcct ggcagttgac acaaggtgct      900

acagtgctgg gcctgttcag agtgacccca gagattccag ccggcctgcc ttctccaaga      960

tccgag                                                                 966


<210>  58
<211>  945
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 16: (DSP107_var3.1 
       without His Tag)

<400>  58
gaagaggaac tgcaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccgc cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagaga gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcgtgaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gagctgtccg tcagagcttc tggtgctaga      360

gcctctcctg gctctgccgc ttctcctaga ctgagagagg gacctgagct gtctcctgat      420

gatcctgctg gcctgctgga tctgagacag ggcatgtttg ctcagctggt ggcccagaac      480

gtgctgctga ttgatggccc tctgtcctgg tactctgatc ctggattggc tggcgtgtcc      540

ctgactggcg gcctgtctta caaagaggac accaaagaac tggtggtggc caaggccggc      600

gtgtactacg tgttctttca gctggaactg cggagagtgg tggccggcga aggatctgga      660

tctgtgtctc tggcactgca tctgcagcct ctgagatctg ctgcaggcgc tgctgctctg      720

gctctgacag ttgatctgcc tcctgcctcc tccgaggcca gaaactccgc ctttggcttc      780

caaggcagac tgctgcatct gtctgccggc cagagactgg gagtccatct gcatacagag      840

gccagagcta gacacgcttg gcagttgaca cagggcgcta cagtgctggg cctgttcaga      900

gtgacacctg agatcccagc cggcctgcct tctccaagat ctgag                      945


<210>  59
<211>  1629
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 18 (DSP107_Var1Mut 
       without His Tag)

<400>  59
gaagaggaaa tccaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccat cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagaat gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatcgact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcgtgaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagctaa accttctgct      360

cccgtggtgt ctggccctgc cgctagagct acacctcagc acaccgtgtc ttttacctgc      420

gagtcccacg gcttcagccc tagagacatc accctgaagt ggttcaagaa cggcaacgag      480

ctgtccgact tccagaccaa cgtggaccct gtgggagagt ccgtgtccta ctccatccac      540

tctaccgcca aggtggtgct gacccgagag gacgtgcaca gccaagtgat ctgtgaagtg      600

gcccacgtga ccctccaggg cgatcctttg agaggcaccg ccaacctgtc cgagacaatc      660

agagtgcctc ctacactgga agtgacccag cagcctgtgc gggccgagaa tcaagtgaac      720

gtgacctgcc aagtgcggaa gttctaccct cagagactgc agctgacctg gctggaaaac      780

ggcaatgtgt ccagaaccga gacagcctcc accgtgaccg agaacaagga tggcacctac      840

aattggatgt cctggctgct cgtgaacgtg tccgctcaca gagatgacgt gaagctgaca      900

tgccaggtgg aacacgatgg ccagcctgcc gtgtctaagt cccacgacct gaaagtgtct      960

gctcacccca aagagcaggg ctccaatacc gccgctgaga acaccggctc caacgagaga     1020

aacatctacg gctctggcgc tagggcctct cctggatctg ctgcttctcc cagactgaga     1080

gagggccctg agctgtctcc tgatgatcct gctggactgc tggatctgag acagggcatg     1140

tttgctcagc tggtggccca gaacgtgctg ctgattgatg gccctctgtc ctggtactct     1200

gatcctggat tggctggcgt gtccctgact ggcggcctgt cttacaaaga ggacaccaaa     1260

gaactggtgg tggccaaggc cggcgtgtac tacgtgttct ttcagctgga actgcggaga     1320

gtggtggccg gcgaaggatc tggatctgtg tctctggctc tgcatctgca gcccctgaga     1380

tctgcagcag gcgctgcagc tctggcactg acagttgatc tgcctcctgc ctcctccgag     1440

gccagaaact ccgcctttgg cttccaaggc agactgctgc acctgtctgc tggacagaga     1500

ctgggagtgc acctccacac agaggccaga gctagacatg cctggcagtt gacacagggc     1560

gctacagtgc tgggcctgtt cagagtgaca cctgagattc cagccggcct gccttctcca     1620

agatccgag                                                             1629


<210>  60
<211>  1605
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 19: (DSP107_Var2Mut 
       without His Tag)

<400>  60
gaagaggaaa tccaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccat cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagaat gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatcgact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcgtgaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagctaa accttctgct      360

cccgtggtgt ctggccctgc cgctagagct acacctcagc acaccgtgtc ttttacctgc      420

gagtcccacg gcttcagccc tagagacatc accctgaagt ggttcaagaa cggcaacgag      480

ctgtccgact tccagaccaa cgtggaccct gtgggagagt ccgtgtccta ctccatccac      540

tctaccgcca aggtggtgct gacccgagag gacgtgcaca gccaagtgat ctgtgaagtg      600

gcccacgtga ccctccaggg cgatcctttg agaggcaccg ccaacctgtc cgagacaatc      660

agagtgcctc ctacactgga agtgacccag cagcctgtgc gggccgagaa tcaagtgaac      720

gtgacctgcc aagtgcggaa gttctaccct cagagactgc agctgacctg gctggaaaac      780

ggcaatgtgt ccagaaccga gacagcctcc accgtgaccg agaacaagga tggcacctac      840

aattggatgt cctggctgct cgtgaacgtg tccgctcaca gagatgacgt gaagctgaca      900

tgccaggtgg aacacgatgg ccagcctgcc gtgtctaagt cccacgacct gaaagtgtct      960

gctcacccca aagagcaggg ctccaatacc gccgctgaga acaccggctc caacgagaga     1020

aacatctacg gctctgccgc ctctcctaga ctgagagagg gacctgagct gtctcctgat     1080

gatcctgctg gcctgctgga tctgagacag ggcatgtttg ctcagctggt ggcccagaac     1140

gtgctgctga ttgatggccc tctgtcctgg tactctgatc ctggattggc tggcgtgtcc     1200

ctgactggcg gcctgtctta caaagaggac accaaagaac tggtggtggc caaggccggc     1260

gtgtactacg tgttctttca gctggaactg cggagagtgg tggccggcga aggatctgga     1320

tctgtgtctc tggctctgca tctgcagccc ctgagatctg ctgcaggcgc tgctgctctg     1380

gcactgacag ttgatctgcc tcctgcctcc tccgaggcca gaaactccgc ctttggcttc     1440

caaggcagac tgctgcatct gtctgccggc cagagactgg gagtccatct gcatacagag     1500

gccagagcta gacacgcttg gcagttgaca cagggcgcta cagtgctggg cctgttcaga     1560

gtgacacctg agatcccagc cggcctgcct tctccaagat ctgag                     1605


<210>  61
<211>  966
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 20 (DSP107_Var3Mut 
       without His Tag)

<400>  61
gaagaggaaa tccaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccat cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagagt gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcatcaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagctgg cgcctgtcct      360

tgggctgtgt ctggcgctag agcatctcct ggctctgctg cctctcctag actgagagag      420

ggacctgagc tgtctcctga tgatcctgct ggcctgctgg atctgagaca gggcatgttt      480

gctcagctgg tggcccagaa cgtgctgctg attgatggcc ctctgtcctg gtactctgat      540

cctggattgg ctggcgtgtc cctgactggc ggcctgtctt acaaagagga caccaaagaa      600

ctggtggtgg ccaaggccgg cgtgtactac gtgttctttc agctggaact gcggagagtg      660

gtggccggcg aaggatctgg atctgtgtct ctggcactgc atctgcagcc cctgagatct      720

gctgcaggcg ctgctgctct ggctctgaca gttgatctgc ctcctgcctc ctccgaggcc      780

agaaactccg cctttggctt ccaaggcaga ctgctgcatc tgtctgccgg ccagagactg      840

ggagtccatc tgcatacaga ggctagagcc aggcacgcct ggcagttgac acaaggtgct      900

acagtgctgg gcctgttcag agtgacccca gagattccag ccggcctgcc ttctccaaga      960

tccgag                                                                 966


<210>  62
<211>  1623
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 45 (Var 4)

<400>  62
gaagaggaac tgcaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccgc cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagaga gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcgtgaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagctaa accttctgct      360

cccgtggtgt ctggccctgc cgctagagct acacctcagc acaccgtgtc ttttacctgc      420

gagtcccacg gcttcagccc tagagacatc accctgaagt ggttcaagaa cggcaacgag      480

ctgtccgact tccagaccaa cgtggaccct gtgggagagt ccgtgtccta ctccatccac      540

tctaccgcca aggtggtgct gacccgagag gacgtgcaca gccaagtgat ctgtgaagtg      600

gcccacgtga ccctccaggg cgatcctttg agaggcaccg ccaacctgtc cgagacaatc      660

agagtgcctc ctacactgga agtgacccag cagcctgtgc gggccgagaa tcaagtgaac      720

gtgacctgcc aagtgcggaa gttctaccct cagagactgc agctgacctg gctggaaaac      780

ggcaatgtgt ccagaaccga gacagcctcc accgtgaccg agaacaagga tggcacctac      840

aattggatgt cctggctgct cgtgaacgtg tccgctcaca gagatgacgt gaagctgaca      900

tgccaggtgg aacacgatgg ccagcctgcc gtgtctaagt cccacgacct gaaagtgtct      960

gctcacccca aagagcaggg ctccaatacc gccgctgaga acaccggctc caacgagaga     1020

aacatctacg gagctagagc atctcctggc tctgctgcct ctcctagact gagagaggga     1080

cctgagctgt ctcctgatga tcctgctggc ctgctggatc tgagacaggg catgtttgct     1140

cagctggtgg cccagaacgt gctgctgatt gatggccctc tgtcctggta ctctgatcct     1200

ggattggctg gcgtgtccct gactggcggc ctgtcttaca aagaggacac caaagaactg     1260

gtggtggcca aggccggcgt gtactacgtg ttctttcagc tggaactgcg gagagtggtg     1320

gccggcgaag gatctggatc tgtgtctctg gcactgcatc tgcagcccct gagatctgct     1380

gcaggcgctg ctgctctggc tctgacagtt gatctgcctc ctgcctcctc cgaggccaga     1440

aactccgcct ttggcttcca aggcagactg ctgcatctgt ctgccggcca gagactggga     1500

gtccatctgc atacagaggc tagagccagg cacgcctggc agttgacaca aggtgctaca     1560

gtgctgggcc tgttcagagt gaccccagag attccagccg gcctgccttc tccaagatcc     1620

gag                                                                   1623


<210>  63
<211>  1587
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 46 (Var 5)

<400>  63
gaagaggaac tgcaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccgc cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagaga gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcgtgaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagctaa accttctgct      360

cccgtggtgt ctggccctgc cgctagagct acacctcagc acaccgtgtc ttttacctgc      420

gagtcccacg gcttcagccc tagagacatc accctgaagt ggttcaagaa cggcaacgag      480

ctgtccgact tccagaccaa cgtggaccct gtgggagagt ccgtgtccta ctccatccac      540

tctaccgcca aggtggtgct gacccgagag gacgtgcaca gccaagtgat ctgtgaagtg      600

gcccacgtga ccctccaggg cgatcctttg agaggcaccg ccaacctgtc cgagacaatc      660

agagtgcctc ctacactgga agtgacccag cagcctgtgc gggccgagaa tcaagtgaac      720

gtgacctgcc aagtgcggaa gttctaccct cagagactgc agctgacctg gctggaaaac      780

ggcaatgtgt ccagaaccga gacagcctcc accgtgaccg agaacaagga tggcacctac      840

aattggatgt cctggctgct cgtgaacgtg tccgctcaca gagatgacgt gaagctgaca      900

tgccaggtgg aacacgatgg ccagcctgcc gtgtctaagt cccacgacct gaaagtgtct      960

gctcacccca aagagcaggg ctccaatacc gccgctgaga acaccggctc caacgagaga     1020

aacatctacg gactgagaga gggacctgag ctgtctcctg atgatcctgc tggcctgctg     1080

gatctgagac agggcatgtt tgctcagctg gtggcccaga acgtgctgct gattgatggc     1140

cctctgtcct ggtactctga tcctggattg gctggcgtgt ccctgactgg cggcctgtct     1200

tacaaagagg acaccaaaga actggtggtg gccaaggccg gcgtgtacta cgtgttcttt     1260

cagctggaac tgcggagagt ggtggccggc gaaggatctg gatctgtgtc tctggcactg     1320

catctgcagc ccctgagatc tgctgcaggc gctgctgctc tggctctgac agttgatctg     1380

cctcctgcct cctccgaggc cagaaactcc gcctttggct tccaaggcag actgctgcat     1440

ctgtctgccg gccagagact gggagtccat ctgcatacag aggctagagc caggcacgcc     1500

tggcagttga cacaaggtgc tacagtgctg ggcctgttca gagtgacccc agagattcca     1560

gccggcctgc cttctccaag atccgag                                         1587


<210>  64
<211>  924
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 47 (Var 6)

<400>  64
gaagaggaac tgcaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccgc cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagaga gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcgtgaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagctgg atctgctgcc      360

tctcctagac tgagagaggg acctgagctg tctcctgatg atcctgctgg cctgctggat      420

ctgagacagg gcatgtttgc tcagctggtg gcccagaacg tgctgctgat tgatggccct      480

ctgtcctggt actctgatcc tggattggct ggcgtgtccc tgactggcgg cctgtcttac      540

aaagaggaca ccaaagaact ggtggtggcc aaggccggcg tgtactacgt gttctttcag      600

ctggaactgc ggagagtggt ggccggcgaa ggatctggat ctgtgtctct ggcactgcat      660

ctgcagcccc tgagatctgc tgcaggcgct gctgctctgg ctctgacagt tgatctgcct      720

cctgcctcct ccgaggccag aaactccgcc tttggcttcc aaggcagact gctgcatctg      780

tctgccggcc agagactggg agtccatctg catacagagg ctagagccag gcacgcctgg      840

cagttgacac aaggtgctac agtgctgggc ctgttcagag tgaccccaga gattccagcc      900

ggcctgcctt ctccaagatc cgag                                             924


<210>  65
<211>  942
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 48 (Var 7)

<400>  65
gaagaggaac tgcaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccgc cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagaga gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcgtgaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagctgg agctagagca      360

tctcctggct ctgctgcctc tcctagactg agagagggac ctgagctgtc tcctgatgat      420

cctgctggcc tgctggatct gagacagggc atgtttgctc agctggtggc ccagaacgtg      480

ctgctgattg atggccctct gtcctggtac tctgatcctg gattggctgg cgtgtccctg      540

actggcggcc tgtcttacaa agaggacacc aaagaactgg tggtggccaa ggccggcgtg      600

tactacgtgt tctttcagct ggaactgcgg agagtggtgg ccggcgaagg atctggatct      660

gtgtctctgg cactgcatct gcagcccctg agatctgctg caggcgctgc tgctctggct      720

ctgacagttg atctgcctcc tgcctcctcc gaggccagaa actccgcctt tggcttccaa      780

ggcagactgc tgcatctgtc tgccggccag agactgggag tccatctgca tacagaggct      840

agagccaggc acgcctggca gttgacacaa ggtgctacag tgctgggcct gttcagagtg      900

accccagaga ttccagccgg cctgccttct ccaagatccg ag                         942


<210>  66
<211>  906
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO: 49 (Var 8)

<400>  66
gaagaggaac tgcaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccgc cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagaga gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcgtgaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagctgg actgagagag      360

ggacctgagc tgtctcctga tgatcctgct ggcctgctgg atctgagaca gggcatgttt      420

gctcagctgg tggcccagaa cgtgctgctg attgatggcc ctctgtcctg gtactctgat      480

cctggattgg ctggcgtgtc cctgactggc ggcctgtctt acaaagagga caccaaagaa      540

ctggtggtgg ccaaggccgg cgtgtactac gtgttctttc agctggaact gcggagagtg      600

gtggccggcg aaggatctgg atctgtgtct ctggcactgc atctgcagcc cctgagatct      660

gctgcaggcg ctgctgctct ggctctgaca gttgatctgc ctcctgcctc ctccgaggcc      720

agaaactccg cctttggctt ccaaggcaga ctgctgcatc tgtctgccgg ccagagactg      780

ggagtccatc tgcatacaga ggctagagcc aggcacgcct ggcagttgac acaaggtgct      840

acagtgctgg gcctgttcag agtgacccca gagattccag ccggcctgcc ttctccaaga      900

tccgag                                                                 906


<210>  67
<211>  1029
<212>  DNA
<213>  Artificial sequence

<220>
<223>  alternative nucleic acid sequence encoding SEQ ID NO: 2 (original
       SIRP fragment)

<400>  67
gaagaggaac tgcaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccgc cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagaga gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcgtgaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gaactgtccg tgcgagctaa accttctgct      360

cccgtggtgt ctggccctgc cgctagagct acacctcagc acaccgtgtc ttttacctgc      420

gagtcccacg gcttcagccc tagagacatc accctgaagt ggttcaagaa cggcaacgag      480

ctgtccgact tccagaccaa cgtggaccct gtgggagagt ccgtgtccta ctccatccac      540

tctaccgcca aggtggtgct gacccgagag gacgtgcaca gccaagtgat ctgtgaagtg      600

gcccacgtga ccctccaggg cgatcctttg agaggcaccg ccaacctgtc cgagacaatc      660

agagtgcctc ctacactgga agtgacccag cagcctgtgc gggccgagaa tcaagtgaac      720

gtgacctgcc aagtgcggaa gttctaccct cagagactgc agctgacctg gctggaaaac      780

ggcaatgtgt ccagaaccga gacagcctcc accgtgaccg agaacaagga tggcacctac      840

aattggatgt cctggctgct cgtgaacgtg tccgctcaca gagatgacgt gaagctgaca      900

tgccaggtgg aacacgatgg ccagcctgcc gtgtctaagt cccacgacct gaaagtgtct      960

gctcacccca aagagcaggg ctccaatacc gccgctgaga acaccggctc caacgagaga     1020

aacatctac                                                             1029


<210>  68
<211>  945
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid SEQUENCE FOR SEQ ID NO: 21

<400>  68
gaagaggaaa tccaagtgat ccagcctgac aagtccgtgc tggtggctgc tggcgaaacc       60

gccacactga gatgtaccat cacctctctg atccctgtgg gccctatcca gtggtttaga      120

ggcgctggac ctggcagagt gctgatctac aaccagaaag agggccactt tcctagagtg      180

accaccgtgt ccgacctgac caagcggaac aacatggact tctccatccg gatcggcaac      240

atcacccctg ctgatgccgg cacctactac tgcatcaagt tccggaaggg ctcccctgac      300

gacgtcgagt ttaaatccgg cgctggcacc gagctgtccg tcagagcttc tggtgctaga      360

gcctctcctg gctctgccgc ttctcctaga ctgagagagg gacctgagct gtctcctgat      420

gatcctgctg gcctgctgga tctgagacag ggcatgtttg ctcagctggt ggcccagaac      480

gtgctgctga ttgatggccc tctgtcctgg tactctgatc ctggattggc tggcgtgtcc      540

ctgactggcg gcctgtctta caaagaggac accaaagaac tggtggtggc caaggccggc      600

gtgtactacg tgttctttca gctggaactg cggagagtgg tggccggcga aggatctgga      660

tctgtgtctc tggcactgca tctgcagcct ctgagatctg ctgcaggcgc tgctgctctg      720

gctctgacag ttgatctgcc tcctgcctcc tccgaggcca gaaactccgc ctttggcttc      780

caaggcagac tgctgcatct gtctgccggc cagagactgg gagtccatct gcatacagag      840

gccagagcta gacacgcttg gcagttgaca cagggcgcta cagtgctggg cctgttcaga      900

gtgacacctg agatcccagc cggcctgcct tctccaagat ctgag                      945


<210>  69
<211>  1749
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cloned sequence of the N-terminal his-tagged (NH)-DSP-107

<400>  69
gaattcccgc cgccaccatg ggctggtcct gcatcattct gtttctggtg gccacagcca       60

ccggcgtgca ctctcaccat catcaccacc atgaagagga actgcaagtg atccagcctg      120

acaagagcgt gctggtggct gctggcgaaa cagccacact gagatgtacc gccacctctc      180

tgatccctgt gggccctatc cagtggttta gaggcgctgg acctggcaga gagctgatct      240

acaaccagaa agagggacac ttccccagag tgaccaccgt gtccgacctg accaagcgga      300

acaacatgga cttcagcatc cggatcggca acatcacccc tgccgatgcc ggcacctact      360

actgcgtgaa gttcagaaag ggcagccccg acgacgtcga gtttaaaagc ggagccggca      420

cagagctgag cgtgcgggct aaaccttctg ctcctgtggt gtctggacct gccgctagag      480

ctacacctca gcacaccgtg tcttttacct gcgagagcca cggcttcagc cccagagata      540

tcaccctgaa gtggttcaag aacggcaacg agctgtccga cttccagacc aacgtggacc      600

ctgtgggaga gagcgtgtcc tacagcatcc acagcacagc caaggtggtg ctgacccggg      660

aagatgtgca ctcccaagtg atttgcgagg tggcccacgt taccctgcaa ggcgatcctc      720

tgagaggcac cgccaatctg agcgagacaa tccgggtgcc acctacactg gaagtgaccc      780

agcagcctgt gcgggccgag aatcaagtga acgtgacctg ccaagtgcgg aagttctacc      840

ctcagagact gcagctgacc tggctggaaa acggcaatgt gtccagaacc gagacagcca      900

gcaccgtgac cgagaacaag gatggcacct acaattggat gagctggctg ctcgtgaatg      960

tgtctgccca ccgggacgat gtgaagctga catgccaggt ggaacacgat ggccagcctg     1020

ccgtgtctaa gagccacgac ctgaaggtgt ccgctcatcc caaagagcag ggctctaata     1080

ctgccgccga gaacaccggc agcaacgaga gaaatatcta cggcgcttgt ccttgggccg     1140

tttctggcgc tagagcctct cctggatctg ccgcttctcc cagactgaga gagggacctg     1200

agctgagccc tgatgatcct gctggactgc tggatctgag acagggcatg tttgcccagc     1260

tggtggccca gaatgtgctg ctgattgatg gccctctgtc ctggtacagc gatcctggac     1320

ttgctggcgt tagcctgact ggcggcctga gctacaaaga ggacaccaaa gaactggtgg     1380

tggccaaggc cggcgtgtac tacgtgttct ttcagctgga actgcggaga gtggtggccg     1440

gcgaaggatc tggatctgtg tctctggctc tgcatctgca gcctctgaga tctgctgctg     1500

gtgctgctgc tctggccctg acagttgatc tgcctcctgc ctctagcgag gccagaaact     1560

ccgcctttgg cttccaaggc agactgctgc acctgagcgc tggacagaga ctgggagtcc     1620

atctgcacac agaagccaga gctagacacg cctggcagct gacacaaggc gctacagtgc     1680

tgggcctgtt cagagtgacc cctgagattc cagccggcct gccatctcct agatctgagt     1740

gataagctt                                                             1749


<210>  70
<211>  184
<212>  PRT
<213>  Artificial sequence

<220>
<223>  4-1BBL -21-0  184 aa

<400>  70

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 


<210>  71
<211>  552
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 70

<400>  71
agagagggcc ctgagctgtc tcctgatgat cctgctggac tgctggacct gagacagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgattg atggccctct gtcctggtac      120

tctgatcctg gattggctgg cgtgtccctg actggcggcc tgtcttacaa agaggacacc      180

aaagaactgg tggtcgccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ctggcgaagg atctggatct gtgtctctgg ccctgcatct gcagcctctg      300

agaagtgctg caggcgctgc tgcactggct ctgacagttg atctgcctcc tgcctcctcc      360

gaggccagaa actccgcctt tggcttccaa ggcagactgc tgcatctgtc tgccggacag      420

agactgggag tgcacctcca tacagaggcc agagctagac acgcttggca gttgacacag      480

ggcgctacag tgctgggcct gtttagagtg acacctgaga tcccagccgg cctgccatct      540

ccaagatctg aa                                                          552


<210>  72
<211>  182
<212>  PRT
<213>  Artificial sequence

<220>
<223>  4-1BBL -23-0 182 aa

<400>  72

Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
1               5                   10                  15      


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
            20                  25                  30          


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
        35                  40                  45              


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
    50                  55                  60                  


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
65                  70                  75                  80  


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
                85                  90                  95      


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
            100                 105                 110         


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
        115                 120                 125             


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
    130                 135                 140                 


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
145                 150                 155                 160 


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
                165                 170                 175     


Pro Ser Pro Arg Ser Glu 
            180         


<210>  73
<211>  546
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 72

<400>  73
ggccctgagc tgtctcctga tgatcctgct ggactgctgg acctgagaca gggcatgttt       60

gctcagctgg tggcccagaa cgtgctgctg attgatggcc ctctgtcctg gtactctgat      120

cctggattgg ctggcgtgtc cctgactggc ggcctgtctt acaaagagga caccaaagaa      180

ctggtggtcg ccaaggccgg cgtgtactac gtgttctttc agctggaact gcggagagtg      240

gtggctggcg aaggatctgg atctgtgtct ctggccctgc atctgcagcc tctgagaagt      300

gctgcaggcg ctgctgcact ggctctgaca gttgatctgc ctcctgcctc ctccgaggcc      360

agaaactccg cctttggctt ccaaggcaga ctgctgcatc tgtctgccgg acagagactg      420

ggagtgcacc tccatacaga ggccagagct agacacgctt ggcagttgac acagggcgct      480

acagtgctgg gcctgtttag agtgacacct gagatcccag ccggcctgcc atctccaaga      540

tctgaa                                                                 546


<210>  74
<211>  183
<212>  PRT
<213>  Artificial sequence

<220>
<223>  4-1BBL -14-8 183 aa

<400>  74

Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
1               5                   10                  15      


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
            20                  25                  30          


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
        35                  40                  45              


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
    50                  55                  60                  


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
65                  70                  75                  80  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
                85                  90                  95      


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
            100                 105                 110         


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
        115                 120                 125             


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
    130                 135                 140                 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
145                 150                 155                 160 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
                165                 170                 175     


Val Thr Pro Glu Ile Pro Ala 
            180             


<210>  75
<211>  551
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 74 551 bp

<400>  75
gatctgccgc ttctcctaga ctgagagagg gccctgagct gtctcctgat gatcctgctg       60

gactgctgga cctgagacag ggcatgtttg ctcagctggt ggcccagaac gtgctgctga      120

ttgatggccc tctgtcctgg tactctgatc ctggattggc tggcgtgtcc ctgactggcg      180

gcctgtctta caaagaggac accaaagaac tggtggtcgc caaggccggc gtgtactacg      240

tgttctttca gctggaactg cggagagtgg tggctggcga aggatctgga tctgtgtctc      300

tggccctgca tctgcagcct ctgagaagtg ctgcaggcgc tgctgcactg gctctgacag      360

ttgatctgcc tcctgcctcc tccgaggcca gaaactccgc ctttggcttc caaggcagac      420

tgctgcatct gtctgccgga cagagactgg gagtgcacct ccatacagag gccagagcta      480

gacacgcttg gcagttgaca cagggcgcta cagtgctggg cctgtttaga gtgacacctg      540

agatcccagc c                                                           551


<210>  76
<211>  176
<212>  PRT
<213>  Artificial sequence

<220>
<223>  4-1BBL -21-8  176 aa

<400>  76

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


<210>  77
<211>  528
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 76 528 bp

<400>  77
agagagggcc ctgagctgtc tcctgatgat cctgctggac tgctggacct gagacagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgattg atggccctct gtcctggtac      120

tctgatcctg gattggctgg cgtgtccctg actggcggcc tgtcttacaa agaggacacc      180

aaagaactgg tggtcgccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ctggcgaagg atctggatct gtgtctctgg ccctgcatct gcagcctctg      300

agaagtgctg caggcgctgc tgcactggct ctgacagttg atctgcctcc tgcctcctcc      360

gaggccagaa actccgcctt tggcttccaa ggcagactgc tgcatctgtc tgccggacag      420

agactgggag tgcacctcca tacagaggcc agagctagac acgcttggca gttgacacag      480

ggcgctacag tgctgggcct gtttagagtg acacctgaga tcccagcc                   528


<210>  78
<211>  601
<212>  PRT
<213>  Artificial sequence

<220>
<223>  sc3x4-1BBL -14-0  601 aa

<400>  78

Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
1               5                   10                  15      


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
            20                  25                  30          


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
        35                  40                  45              


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
    50                  55                  60                  


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
65                  70                  75                  80  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
                85                  90                  95      


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
            100                 105                 110         


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
        115                 120                 125             


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
    130                 135                 140                 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
145                 150                 155                 160 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
                165                 170                 175     


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala 
        195                 200                 205             


Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala 
    210                 215                 220                 


Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
225                 230                 235                 240 


Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
                245                 250                 255     


Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
            260                 265                 270         


Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
        275                 280                 285             


Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
    290                 295                 300                 


Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
305                 310                 315                 320 


Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
                325                 330                 335     


Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
            340                 345                 350         


Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
        355                 360                 365             


Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 
    370                 375                 380                 


Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ser Pro Arg 
                405                 410                 415     


Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu 
            420                 425                 430         


Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
        435                 440                 445             


Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
    450                 455                 460                 


Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
465                 470                 475                 480 


Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
                485                 490                 495     


Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
            500                 505                 510         


His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
        515                 520                 525             


Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
    530                 535                 540                 


Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
545                 550                 555                 560 


Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                565                 570                 575     


Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
            580                 585                 590         


Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        595                 600     


<210>  79
<211>  1803
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 78

<400>  79
tctgccgcca gccctaggct gcgcgaggga cccgagctga gcccagacga tcccgccggc       60

ctgctggacc tgaggcaggg aatgttcgca cagctggtgg cccagaacgt gctgctgatc      120

gacggccctc tgtcctggta ctctgatcca ggcctggccg gcgtgtccct gacaggaggc      180

ctgtcttata aggaggatac caaggagctg gtggtggcaa aggcaggcgt gtactacgtg      240

ttcttccagc tggagctgag gagagtggtg gcaggagagg gcagcggctc cgtgtctctg      300

gccctgcacc tccagcctct gcggagcgcc gccggcgccg ccgccctggc cctgaccgtg      360

gatctgcctc cagccagctc cgaggccagg aatagcgcct tcggctttca gggccgcctg      420

ctgcacctgt ccgccggcca gcggctggga gtgcacctgc acacagaggc cagagcccgg      480

cacgcatggc agctgacaca gggagcaacc gtgctgggcc tgttccgcgt gacccctgag      540

atcccagccg gcctgccaag cccccggtcc gagggcggcg gcggctctgg cggaggaggc      600

agcggaggcg gcggctctgc cgccagcccc aggctgcgcg agggacccga gctgtcccca      660

gacgatcctg ccggcctgct ggacctgcgc cagggaatgt ttgcccagct ggtggctcaa      720

aacgtgctgt taatcgacgg ccctctgagc tggtactctg atcctggcct ggccggcgtg      780

agcctgaccg gcggcctgtc ctacaaagag gatactaaag agctggtggt cgccaaagcc      840

ggcgtgtact acgtgttctt ccaactggag ctgaggaggg tcgtcgccgg cgaaggcagc      900

ggctccgtgt ctctggccct gcacctccag ccgctgagga gcgccgccgg cgccgccgcc      960

ctggccctga cggtggacct gccacctgcc tctagcgagg caagaaattc tgccttcggc     1020

ttccagggca ggctgctgca cctgagcgcc ggccagcgcc tgggcgtcca cctgcatacc     1080

gaagccagag cccggcatgc ctggcagctg acccagggcg ccaccgtgct gggcctgttc     1140

agagtgaccc cagagatccc cgccggcctg cctagcccaa ggtccgaagg cggcggcggc     1200

tccggcggcg gaggctctgg aggagggggc tctgccgcca gcccaaggct gcgcgaggga     1260

cccgagctgt cgcctgacga tccagccggc ctgctggacc tgcgtcaggg catgttcgcc     1320

cagctggtgg ctcagaacgt gctgttaatc gacggcccac tgtcttggta ttctgatccc     1380

ggcctggccg gcgtgtctct gacaggaggc ctgagctaca aagaggatac aaaagagctg     1440

gtggtcgcta aagctggcgt gtactacgtg ttcttccaac tggagctgcg cagggtcgtc     1500

gccggcgagg gcagcggctc cgtgtctctg gccctgcacc tccagccatt acggagcgcc     1560

gccggcgccg ccgccctggc cctgactgtg gacctgccac cagcctcctc tgaggcacgg     1620

aacagcgcct tcggcttcca aggcagactg ctgcacctgt ctgccggcca gaggctgggc     1680

gtccacctgc acaccgaagc cagagcccgg cacgcctggc agctgactca gggcgctacc     1740

gtgctgggcc tgttccgcgt aaccccagag atccctgccg gcctgcccag ccctcggtcc     1800

gag                                                                   1803


<210>  80
<211>  535
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP107_Var2

<400>  80

Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
1               5                   10                  15      


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
            20                  25                  30          


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
        35                  40                  45              


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
    50                  55                  60                  


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
65                  70                  75                  80  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
                85                  90                  95      


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
            100                 105                 110         


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
        115                 120                 125             


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
    130                 135                 140                 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
145                 150                 155                 160 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
                165                 170                 175     


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly 
            180                 185                 190         


Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
        195                 200                 205             


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
    210                 215                 220                 


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
225                 230                 235                 240 


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
                245                 250                 255     


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
            260                 265                 270         


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
        275                 280                 285             


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
    290                 295                 300                 


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
305                 310                 315                 320 


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
                325                 330                 335     


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
            340                 345                 350         


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
        355                 360                 365             


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
    370                 375                 380                 


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
385                 390                 395                 400 


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
                405                 410                 415     


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
            420                 425                 430         


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
        435                 440                 445             


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
    450                 455                 460                 


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
465                 470                 475                 480 


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
                485                 490                 495     


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
            500                 505                 510         


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
        515                 520                 525             


Ser Asn Glu Arg Asn Ile Tyr 
    530                 535 


<210>  81
<211>  699
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA sequence of SEQ ID NO: 80

<400>  81
tctgctgcct ctcctagact gagagaggga cctgagctgt ctcctgatga tcctgctggc       60

ctgctggatc tgagacaggg catgtttgct cagctggtgg cccagaacgt gctgctgatt      120

gatggccctc tgtcctggta ctctgatcct ggattggctg gcgtgtccct gactggcggc      180

ctgtcttaca aagaggacac caaagaactg gtggtggcca aggccggcgt gtactacgtg      240

ttctttcagc tggaactgcg gagagtggtg gccggcgaag gatctggatc tgtgtctctg      300

gcactgcatc tgcagcccct gagatctgct gcaggcgctg ctgctctggc tctgacagtt      360

gatctgcctc ctgcctcctc cgaggccaga aactccgcct ttggcttcca aggcagactg      420

ctgcatctgt ctgccggcca gagactggga gtccatctgc atacagaggc tagagccagg      480

cacgcctggc agttgacaca aggtgctaca gtgctgggcc tgttcagagt gaccccagag      540

attccagccg gcctgccttc tccaagatcc gagggcgaag aggaactgca agtgatccag      600

cctgacaagt ccgtgctggt ggctgctggc gaaaccgcca cactgagatg taccgccacc      660

tctctgatcc ctgtgggccc tatccagtgg tttagaggc                             699


<210>  82
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  82

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  83
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  83

Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   


<210>  84
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  may repeat 1-4 times

<400>  84

Gly Gly Gly Gly Ser 
1               5   


<210>  85
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  85

Gly Gly Gly Gly Ser 
1               5   


<210>  86
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  86

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  87
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  may repeat 1-3 times

<400>  87

Glu Ala Ala Ala Lys 
1               5   


<210>  88
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker


<220>
<221>  REPEAT
<222>  (2)..(6)
<223>  repeat 2-5 times

<400>  88

Ala Glu Ala Ala Ala Lys Ala 
1               5           


<210>  89
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  89

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  90
<211>  46
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  90

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  91
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  91

Pro Ala Pro Ala Pro 
1               5   


<210>  92
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  92

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  93
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  93

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  94
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  94

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  95
<211>  229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  95

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  96
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  96

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  97
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  97

Gly Leu Pro Ser Pro Arg Ser Glu 
1               5               


<210>  98
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  98

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu 
            20              


<210>  99
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide linker

<400>  99

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val Leu Ser 
            


