                         SEQUENCE LISTING

<110>  KAHR Medical Ltd.
       PECKER, Iris
       BLOCH, Itai
 
<120>  PD1-4-1BBL VARIANT FUSION PROTEIN AND METHODS OF USE THEREOF

<130>  77792

<150>  62/696,365
<151>  2018-07-11

<150>  62/786,599
<151>  2018-12-31

<160>  169   

<170>  PatentIn version 3.5

<210>  1
<211>  362
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ORIGINAL PD1-41BBL with signal peptide and His Tag

<400>  1

His His His His His His Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg 
1               5                   10                  15      


Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
            20                  25                  30          


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
        35                  40                  45              


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
    50                  55                  60                  


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
65                  70                  75                  80  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
                85                  90                  95      


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
            100                 105                 110         


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
        115                 120                 125             


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
    130                 135                 140                 


Ser Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Gly Ala Cys Pro 
145                 150                 155                 160 


Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro 
                165                 170                 175     


Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
            180                 185                 190         


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
        195                 200                 205             


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
    210                 215                 220                 


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
225                 230                 235                 240 


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
                245                 250                 255     


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
            260                 265                 270         


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
        275                 280                 285             


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
    290                 295                 300                 


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
305                 310                 315                 320 


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
                325                 330                 335     


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
            340                 345                 350         


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        355                 360         


<210>  2
<211>  150
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ORIGINAL PD1 DOMAIN

<400>  2

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  3
<211>  205
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ORIGINAL 41BBL DOMAIN

<400>  3

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            20                  25                  30          


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        35                  40                  45              


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    50                  55                  60                  


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
65                  70                  75                  80  


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                85                  90                  95      


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            100                 105                 110         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        115                 120                 125             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    130                 135                 140                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
145                 150                 155                 160 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                165                 170                 175     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            180                 185                 190         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200                 205 


<210>  4
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SIGNAL PEPTIDE

<400>  4

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  5
<211>  356
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ORIGINAL PD1-41BBL without His Tag

<400>  5

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Gly Ala Cys Pro Trp Ala Val Ser Gly Ala 
145                 150                 155                 160 


Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro 
                165                 170                 175     


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
            180                 185                 190         


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
        195                 200                 205             


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
    210                 215                 220                 


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
225                 230                 235                 240 


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                245                 250                 255     


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
            260                 265                 270         


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
        275                 280                 285             


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
    290                 295                 300                 


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
305                 310                 315                 320 


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
                325                 330                 335     


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser 
            340                 345                 350         


Pro Arg Ser Glu 
        355     


<210>  6
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal segment of PD1

<400>  6

Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln 
1               5                   10                  15      


Phe Gln Thr Leu Val 
            20      


<210>  7
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  N-terminal segment of the 4-1BBL

<400>  7

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
            20                  25                  30  


<210>  8
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  segment of five residues at the N-terminal of PD1

<400>  8

Pro Gly Trp Phe Leu 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  segment of five residues at the C-terminal of PD1

<400>  9

Phe Gln Thr Leu Val 
1               5   


<210>  10
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  N-terminal segment of the 4-1BBL domain

<400>  10

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly 
1               5                   10                  


<210>  11
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  N-terminal segment of the 4-1BBL domain

<400>  11

Ala Cys Pro Trp Ala Val 
1               5       


<210>  12
<211>  332
<212>  PRT
<213>  Artificial sequence

<220>
<223>  K105_var1 without His Tag

<400>  12

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Gly Ser Ala Ala 
    130                 135                 140                 


Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala 
145                 150                 155                 160 


Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
                165                 170                 175     


Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
            180                 185                 190         


Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
        195                 200                 205             


Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
    210                 215                 220                 


Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
225                 230                 235                 240 


Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                245                 250                 255     


Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
            260                 265                 270         


Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
        275                 280                 285             


Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
    290                 295                 300                 


Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 
305                 310                 315                 320 


Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                325                 330         


<210>  13
<211>  338
<212>  PRT
<213>  Artificial sequence

<220>
<223>  K105_var1 with His Tag

<400>  13

His His His His His His Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro 
1               5                   10                  15      


Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr 
            20                  25                  30          


Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp 
        35                  40                  45              


Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro 
    50                  55                  60                  


Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln 
65                  70                  75                  80  


Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg 
                85                  90                  95      


Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys 
            100                 105                 110         


Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120                 125             


Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala 
    130                 135                 140                 


Gly Gln Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu 
145                 150                 155                 160 


Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe 
                165                 170                 175     


Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser 
            180                 185                 190         


Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
        195                 200                 205             


Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
    210                 215                 220                 


Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu 
225                 230                 235                 240 


Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser 
                245                 250                 255     


Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala 
            260                 265                 270         


Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu 
        275                 280                 285             


His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala 
    290                 295                 300                 


Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly 
305                 310                 315                 320 


Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg 
                325                 330                 335     


Ser Glu 
        


<210>  14
<211>  338
<212>  PRT
<213>  Artificial sequence

<220>
<223>  K105_var2 without His Tag

<400>  14

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Gly Ala Arg Ala 
    130                 135                 140                 


Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu 
145                 150                 155                 160 


Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe 
                165                 170                 175     


Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser 
            180                 185                 190         


Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
        195                 200                 205             


Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
    210                 215                 220                 


Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu 
225                 230                 235                 240 


Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser 
                245                 250                 255     


Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala 
            260                 265                 270         


Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu 
        275                 280                 285             


His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala 
    290                 295                 300                 


Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly 
305                 310                 315                 320 


Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg 
                325                 330                 335     


Ser Glu 
        


<210>  15
<211>  344
<212>  PRT
<213>  Artificial sequence

<220>
<223>  K105_var2 with His Tag

<400>  15

His His His His His His Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro 
1               5                   10                  15      


Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr 
            20                  25                  30          


Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp 
        35                  40                  45              


Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro 
    50                  55                  60                  


Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln 
65                  70                  75                  80  


Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg 
                85                  90                  95      


Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys 
            100                 105                 110         


Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120                 125             


Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala 
    130                 135                 140                 


Gly Gln Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu 
145                 150                 155                 160 


Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
                165                 170                 175     


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            180                 185                 190         


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        195                 200                 205             


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    210                 215                 220                 


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
225                 230                 235                 240 


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                245                 250                 255     


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            260                 265                 270         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        275                 280                 285             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    290                 295                 300                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
305                 310                 315                 320 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                325                 330                 335     


Gly Leu Pro Ser Pro Arg Ser Glu 
            340                 


<210>  16
<211>  326
<212>  PRT
<213>  Artificial sequence

<220>
<223>  K105_var3 without His Tag

<400>  16

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Gly Leu Arg Glu 
    130                 135                 140                 


Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
145                 150                 155                 160 


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                165                 170                 175     


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            180                 185                 190         


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        195                 200                 205             


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    210                 215                 220                 


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
225                 230                 235                 240 


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                245                 250                 255     


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            260                 265                 270         


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        275                 280                 285             


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    290                 295                 300                 


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
305                 310                 315                 320 


Pro Ser Pro Arg Ser Glu 
                325     


<210>  17
<211>  332
<212>  PRT
<213>  Artificial sequence

<220>
<223>  K105_var3 with His Tag

<400>  17

His His His His His His Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro 
1               5                   10                  15      


Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr 
            20                  25                  30          


Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp 
        35                  40                  45              


Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro 
    50                  55                  60                  


Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln 
65                  70                  75                  80  


Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg 
                85                  90                  95      


Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys 
            100                 105                 110         


Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120                 125             


Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala 
    130                 135                 140                 


Gly Gln Gly Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala 
145                 150                 155                 160 


Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
                165                 170                 175     


Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
            180                 185                 190         


Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
        195                 200                 205             


Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
    210                 215                 220                 


Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
225                 230                 235                 240 


Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                245                 250                 255     


Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
            260                 265                 270         


Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
        275                 280                 285             


Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
    290                 295                 300                 


Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 
305                 310                 315                 320 


Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                325                 330         


<210>  18
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  140 aa PD1 segment

<400>  18

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln 
    130                 135                 140 


<210>  19
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  128 aa PD1 segment

<400>  19

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


<210>  20
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  135 aa PD1 segment

<400>  20

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


Ser Pro Arg Pro Ala Gly Gln 
    130                 135 


<210>  21
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  133 aa PD1 segment

<400>  21

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro 
    130             


<210>  22
<211>  191
<212>  PRT
<213>  Artificial sequence

<220>
<223>  191 aa 41BBL segment

<400>  22

Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
1               5                   10                  15      


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
            20                  25                  30          


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
        35                  40                  45              


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
    50                  55                  60                  


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
65                  70                  75                  80  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
                85                  90                  95      


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
            100                 105                 110         


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
        115                 120                 125             


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
    130                 135                 140                 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
145                 150                 155                 160 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
                165                 170                 175     


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 185                 190     


<210>  23
<211>  197
<212>  PRT
<213>  Artificial sequence

<220>
<223>  197 aa 41BBL segment

<400>  23

Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
1               5                   10                  15      


Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln 
            20                  25                  30          


Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
        35                  40                  45              


Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
    50                  55                  60                  


Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
65                  70                  75                  80  


Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
                85                  90                  95      


Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
            100                 105                 110         


Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
        115                 120                 125             


Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
    130                 135                 140                 


Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His 
145                 150                 155                 160 


Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
                165                 170                 175     


Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro 
            180                 185                 190         


Ser Pro Arg Ser Glu 
        195         


<210>  24
<211>  185
<212>  PRT
<213>  Artificial sequence

<220>
<223>  185 aa 41BBL segment

<400>  24

Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu 
1               5                   10                  15      


Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
            20                  25                  30          


Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
        35                  40                  45              


Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
    50                  55                  60                  


Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
65                  70                  75                  80  


Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
                85                  90                  95      


His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
            100                 105                 110         


Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
        115                 120                 125             


Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
    130                 135                 140                 


Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
145                 150                 155                 160 


Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
                165                 170                 175     


Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 185 


<210>  25
<211>  199
<212>  PRT
<213>  Artificial sequence

<220>
<223>  199 aa 41BBL segment

<400>  25

Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg 
1               5                   10                  15      


Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
            20                  25                  30          


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
        35                  40                  45              


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
    50                  55                  60                  


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
65                  70                  75                  80  


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
                85                  90                  95      


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
            100                 105                 110         


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
        115                 120                 125             


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
    130                 135                 140                 


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
145                 150                 155                 160 


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
                165                 170                 175     


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
            180                 185                 190         


Leu Pro Ser Pro Arg Ser Glu 
        195                 


<210>  26
<211>  381
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ORIGINAL PD1-41BBL with signal peptide and His Tag

<400>  26

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser His His His His His His Pro Gly Trp Phe Leu Asp Ser 
            20                  25                  30          


Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val 
        35                  40                  45              


Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr 
    50                  55                  60                  


Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln 
65                  70                  75                  80  


Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln 
                85                  90                  95      


Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His 
            100                 105                 110         


Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys 
        115                 120                 125             


Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg 
    130                 135                 140                 


Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His 
145                 150                 155                 160 


Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Gly 
                165                 170                 175     


Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
            180                 185                 190         


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
        195                 200                 205             


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
    210                 215                 220                 


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
225                 230                 235                 240 


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
                245                 250                 255     


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
            260                 265                 270         


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
        275                 280                 285             


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
    290                 295                 300                 


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
305                 310                 315                 320 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
                325                 330                 335     


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
            340                 345                 350         


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
        355                 360                 365             


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
    370                 375                 380     


<210>  27
<211>  288
<212>  PRT
<213>  Artificial sequence

<220>
<223>  aa sequence of full length PD1

<400>  27

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  28
<211>  867
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence of full length PD1

<400>  28
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atctgctccc gggccgcacg agggacaata      600

ggagccaggc gcaccggcca gcccctgaag gaggacccct cagccgtgcc tgtgttctct      660

gtggactatg gggagctgga tttccagtgg cgagagaaga ccccggagcc ccccgtgccc      720

tgtgtccctg agcagacgga gtatgccacc attgtctttc ctagcggaat gggcacctca      780

tcccccgccc gcaggggctc agctgacggc cctcggagtg cccagccact gaggcctgag      840

gatggacact gctcttggcc cctctga                                          867


<210>  29
<211>  450
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 2

<400>  29
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      420

aggccagccg gccagttcca aaccctggtg                                       450


<210>  30
<211>  167
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 amino acid sequence

<400>  30

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln 
                165         


<210>  31
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 amino acid sequence

<400>  31

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  32
<211>  420
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 18

<400>  32
gactcccctg acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgccggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgccggccag      420


<210>  33
<211>  384
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 19

<400>  33
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactgcc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc acct                                             384


<210>  34
<211>  405
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 20

<400>  34
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactgcc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc accttctcca agacctgccg gccag                      405


<210>  35
<211>  399
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 21

<400>  35
gactcccctg acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgccggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacct                             399


<210>  36
<211>  254
<212>  PRT
<213>  Artificial sequence

<220>
<223>  aa sequence of full length 41BBL

<400>  36

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  37
<211>  765
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence of full length 41BBL

<400>  37
atggaatacg cctctgacgc ttcactggac cccgaagccc cgtggcctcc cgcgccccgc       60

gctcgcgcct gccgcgtact gccttgggcc ctggtcgcgg ggctgctgct gctgctgctg      120

ctcgctgccg cctgcgccgt cttcctcgcc tgcccctggg ccgtgtccgg ggctcgcgcc      180

tcgcccggct ccgcggccag cccgagactc cgcgagggtc ccgagctttc gcccgacgat      240

cccgccggcc tcttggacct gcggcagggc atgtttgcgc agctggtggc ccaaaatgtt      300

ctgctgatcg atgggcccct gagctggtac agtgacccag gcctggcagg cgtgtccctg      360

acggggggcc tgagctacaa agaggacacg aaggagctgg tggtggccaa ggctggagtc      420

tactatgtct tctttcaact agagctgcgg cgcgtggtgg ccggcgaggg ctcaggctcc      480

gtttcacttg cgctgcacct gcagccactg cgctctgctg ctggggccgc cgccctggct      540

ttgaccgtgg acctgccacc cgcctcctcc gaggctcgga actcggcctt cggtttccag      600

ggccgcttgc tgcacctgag tgccggccag cgcctgggcg tccatcttca cactgaggcc      660

agggcacgcc atgcctggca gcttacccag ggcgccacag tcttgggact cttccgggtg      720

acccccgaaa tcccagccgg actcccttca ccgaggtcgg aataa                      765


<210>  38
<211>  615
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 3

<400>  38
gcctgcccct gggccgtgtc cggggctcgc gcctcgcccg gctccgcggc cagcccgaga       60

ctccgcgagg gtcccgagct ttcgcccgac gatcccgccg gcctcttgga cctgcggcag      120

ggcatgtttg cgcagctggt ggcccaaaat gttctgctga tcgatgggcc cctgagctgg      180

tacagtgacc caggcctggc aggcgtgtcc ctgacggggg gcctgagcta caaagaggac      240

acgaaggagc tggtggtggc caaggctgga gtctactatg tcttctttca actagagctg      300

cggcgcgtgg tggccggcga gggctcaggc tccgtttcac ttgcgctgca cctgcagcca      360

ctgcgctctg ctgctggggc cgccgccctg gctttgaccg tggacctgcc acccgcctcc      420

tccgaggctc ggaactcggc cttcggtttc cagggccgct tgctgcacct gagtgccggc      480

cagcgcctgg gcgtccatct tcacactgag gccagggcac gccatgcctg gcagcttacc      540

cagggcgcca cagtcttggg actcttccgg gtgacccccg aaatcccagc cggactccct      600

tcaccgaggt cggaa                                                       615


<210>  39
<211>  573
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 22

<400>  39
tctgccgctt ctcccagact gagagaagga cctgagctga gccctgatga tcctgctgga       60

ctgctggatc tgcggcaggg catgtttgct cagttggtgg cccagaacgt gctgctgatc      120

gatggccctc tgtcctggta ctctgatcca ggattggctg gcgtgtccct gactggcggc      180

ctgtcttaca aagaggacac caaagaactg gtggtggcca aggccggcgt gtactacgtg      240

ttctttcagc tggaactgcg gagagtggtg gctggcgaag gatctggatc tgtgtctctg      300

gccctgcatc tgcagcctct gagaagtgct gcaggcgctg ctgcactggc tctgacagtt      360

gatctgcctc ctgcctcctc cgaggccaga aactccgcct ttggcttcca aggcagactg      420

ctgcacctgt ccgctggaca gagactggga gtccatctgc acacagaggc cagagctaga      480

cacgcttggc agttgacaca gggcgctaca gtgctgggcc tgtttagagt gacccctgag      540

attccagccg gcctgccatc tcctagatct gag                                   573


<210>  40
<211>  591
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 23

<400>  40
gctagagctt ctcctggctc tgccgcttct cccagactga gagaaggacc tgagctgagc       60

cctgatgatc ctgctggact gctggatctg cggcagggca tgtttgctca gttggtggcc      120

cagaacgtgc tgctgatcga tggccctctg tcctggtact ctgatccagg attggctggc      180

gtgtccctga ctggcggcct gtcttacaaa gaggacacca aagaactggt ggtggccaag      240

gccggcgtgt actacgtgtt ctttcagctg gaactgcgga gagtggtggc tggcgaagga      300

tctggatctg tgtctctggc cctgcatctg cagcctctga gaagtgctgc aggcgctgct      360

gcactggctc tgacagttga tctgcctcct gcctcctccg aggccagaaa ctccgccttt      420

ggcttccaag gcagactgct gcacctgtcc gctggacaga gactgggagt ccatctgcac      480

acagaggcca gagctagaca cgcttggcag ttgacacagg gcgctacagt gctgggcctg      540

tttagagtga cccctgagat tccagccggc ctgccatctc ctagatctga g               591


<210>  41
<211>  555
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 24

<400>  41
ctgagagaag gacctgagct gagccctgat gatcctgctg gactgctgga tctgcggcag       60

ggcatgtttg ctcagttggt ggcccagaac gtgctgctga tcgatggccc tctgtcctgg      120

tactctgatc caggattggc tggcgtgtcc ctgactggcg gcctgtctta caaagaggac      180

accaaagaac tggtggtggc caaggccggc gtgtactacg tgttctttca gctggaactg      240

cggagagtgg tggctggcga aggatctgga tctgtgtctc tggccctgca tctgcagcct      300

ctgagaagtg ctgcaggcgc tgctgcactg gctctgacag ttgatctgcc tcctgcctcc      360

tccgaggcca gaaactccgc ctttggcttc caaggcagac tgctgcacct gtccgctgga      420

cagagactgg gagtccatct gcacacagag gccagagcta gacacgcttg gcagttgaca      480

cagggcgcta cagtgctggg cctgtttaga gtgacccctg agattccagc cggcctgcca      540

tctcctagat ctgag                                                       555


<210>  42
<211>  597
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 25

<400>  42
tctggcgcta gagcttctcc tggctctgcc gcttctccca gactgagaga aggacctgag       60

ctgagccctg atgatcctgc tggactgctg gatctgcggc agggcatgtt tgctcagttg      120

gtggcccaga acgtgctgct gatcgatggc cctctgtcct ggtactctga tccaggattg      180

gctggcgtgt ccctgactgg cggcctgtct tacaaagagg acaccaaaga actggtggtg      240

gccaaggccg gcgtgtacta cgtgttcttt cagctggaac tgcggagagt ggtggctggc      300

gaaggatctg gatctgtgtc tctggccctg catctgcagc ctctgagaag tgctgcaggc      360

gctgctgcac tggctctgac agttgatctg cctcctgcct cctccgaggc cagaaactcc      420

gcctttggct tccaaggcag actgctgcac ctgtccgctg gacagagact gggagtccat      480

ctgcacacag aggccagagc tagacacgct tggcagttga cacagggcgc tacagtgctg      540

ggcctgttta gagtgacccc tgagattcca gccggcctgc catctcctag atctgag         597


<210>  43

<400>  43
000

<210>  44
<211>  340
<212>  PRT
<213>  Artificial sequence

<220>
<223>  var 4

<400>  44

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Gly Ser Gly Ala 
    130                 135                 140                 


Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro 
145                 150                 155                 160 


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
                165                 170                 175     


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
            180                 185                 190         


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
        195                 200                 205             


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
    210                 215                 220                 


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
225                 230                 235                 240 


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
                245                 250                 255     


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
            260                 265                 270         


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
        275                 280                 285             


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
    290                 295                 300                 


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
305                 310                 315                 320 


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser 
                325                 330                 335     


Pro Arg Ser Glu 
            340 


<210>  45
<211>  333
<212>  PRT
<213>  Artificial sequence

<220>
<223>  var 5

<400>  45

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Gly Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
    130                 135                 140                 


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
145                 150                 155                 160 


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
                165                 170                 175     


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
            180                 185                 190         


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
        195                 200                 205             


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
    210                 215                 220                 


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
225                 230                 235                 240 


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
                245                 250                 255     


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
            260                 265                 270         


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
        275                 280                 285             


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
    290                 295                 300                 


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
305                 310                 315                 320 


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                325                 330             


<210>  46
<211>  325
<212>  PRT
<213>  Artificial sequence

<220>
<223>  var 6

<400>  46

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
    130                 135                 140                 


Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln 
145                 150                 155                 160 


Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
                165                 170                 175     


Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
            180                 185                 190         


Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
        195                 200                 205             


Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
    210                 215                 220                 


Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
225                 230                 235                 240 


Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
                245                 250                 255     


Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
            260                 265                 270         


Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His 
        275                 280                 285             


Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
    290                 295                 300                 


Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro 
305                 310                 315                 320 


Ser Pro Arg Ser Glu 
                325 


<210>  47
<211>  331
<212>  PRT
<213>  Artificial sequence

<220>
<223>  var 7

<400>  47

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser 
    130                 135                 140                 


Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
145                 150                 155                 160 


Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn 
                165                 170                 175     


Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu 
            180                 185                 190         


Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
        195                 200                 205             


Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
    210                 215                 220                 


Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
225                 230                 235                 240 


Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu 
                245                 250                 255     


Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
            260                 265                 270         


Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
        275                 280                 285             


Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
    290                 295                 300                 


Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
305                 310                 315                 320 


Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                325                 330     


<210>  48
<211>  319
<212>  PRT
<213>  Artificial sequence

<220>
<223>  var 8

<400>  48

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Gly Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
    130                 135                 140                 


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
145                 150                 155                 160 


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
                165                 170                 175     


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
            180                 185                 190         


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
        195                 200                 205             


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
    210                 215                 220                 


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
225                 230                 235                 240 


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
                245                 250                 255     


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
            260                 265                 270         


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
        275                 280                 285             


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
    290                 295                 300                 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
305                 310                 315                 


<210>  49
<211>  328
<212>  PRT
<213>  Artificial sequence

<220>
<223>  var 9

<400>  49

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


Gly Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu 
    130                 135                 140                 


Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
145                 150                 155                 160 


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
                165                 170                 175     


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
            180                 185                 190         


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
        195                 200                 205             


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
    210                 215                 220                 


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
225                 230                 235                 240 


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
                245                 250                 255     


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
            260                 265                 270         


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
        275                 280                 285             


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
    290                 295                 300                 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
305                 310                 315                 320 


Gly Leu Pro Ser Pro Arg Ser Glu 
                325             


<210>  50
<211>  320
<212>  PRT
<213>  Artificial sequence

<220>
<223>  var 10

<400>  50

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro 
    130                 135                 140                 


Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
145                 150                 155                 160 


Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
                165                 170                 175     


Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
            180                 185                 190         


Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr 
        195                 200                 205             


Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
    210                 215                 220                 


Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 
225                 230                 235                 240 


Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser 
                245                 250                 255     


Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
            260                 265                 270         


Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
        275                 280                 285             


Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
    290                 295                 300                 


Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
305                 310                 315                 320 


<210>  51
<211>  326
<212>  PRT
<213>  Artificial sequence

<220>
<223>  var 11

<400>  51

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu 
    130                 135                 140                 


Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
145                 150                 155                 160 


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                165                 170                 175     


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            180                 185                 190         


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        195                 200                 205             


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    210                 215                 220                 


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
225                 230                 235                 240 


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                245                 250                 255     


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            260                 265                 270         


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        275                 280                 285             


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    290                 295                 300                 


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
305                 310                 315                 320 


Pro Ser Pro Arg Ser Glu 
                325     


<210>  52
<211>  314
<212>  PRT
<213>  Artificial sequence

<220>
<223>  var 12

<400>  52

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


Gly Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
    130                 135                 140                 


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
145                 150                 155                 160 


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
                165                 170                 175     


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
            180                 185                 190         


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
        195                 200                 205             


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
    210                 215                 220                 


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
225                 230                 235                 240 


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
                245                 250                 255     


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
            260                 265                 270         


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
        275                 280                 285             


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
    290                 295                 300                 


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
305                 310                 


<210>  53
<211>  335
<212>  PRT
<213>  Artificial sequence

<220>
<223>  var 13

<400>  53

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


Ser Pro Arg Pro Ala Gly Gln Gly Ser Gly Ala Arg Ala Ser Pro Gly 
    130                 135                 140                 


Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
145                 150                 155                 160 


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
                165                 170                 175     


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            180                 185                 190         


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        195                 200                 205             


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    210                 215                 220                 


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
225                 230                 235                 240 


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                245                 250                 255     


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            260                 265                 270         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        275                 280                 285             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    290                 295                 300                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
305                 310                 315                 320 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                325                 330                 335 


<210>  54
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  var 14

<400>  54

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


Ser Pro Arg Pro Ala Gly Gln Gly Ser Ala Ala Ser Pro Arg Leu Arg 
    130                 135                 140                 


Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
145                 150                 155                 160 


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
                165                 170                 175     


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
            180                 185                 190         


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
        195                 200                 205             


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
    210                 215                 220                 


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
225                 230                 235                 240 


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
                245                 250                 255     


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
            260                 265                 270         


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
        275                 280                 285             


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
    290                 295                 300                 


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
305                 310                 315                 320 


Leu Pro Ser Pro Arg Ser Glu 
                325         


<210>  55
<211>  333
<212>  PRT
<213>  Artificial sequence

<220>
<223>  var 15

<400>  55

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


Ser Pro Arg Pro Ala Gly Gln Gly Ala Arg Ala Ser Pro Gly Ser Ala 
    130                 135                 140                 


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
145                 150                 155                 160 


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
                165                 170                 175     


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
            180                 185                 190         


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
        195                 200                 205             


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
    210                 215                 220                 


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
225                 230                 235                 240 


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
                245                 250                 255     


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
            260                 265                 270         


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
        275                 280                 285             


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
    290                 295                 300                 


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
305                 310                 315                 320 


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                325                 330             


<210>  56
<211>  321
<212>  PRT
<213>  Artificial sequence

<220>
<223>  var 16

<400>  56

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


Ser Pro Arg Pro Ala Gly Gln Gly Leu Arg Glu Gly Pro Glu Leu Ser 
    130                 135                 140                 


Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
145                 150                 155                 160 


Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                165                 170                 175     


Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
            180                 185                 190         


Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
        195                 200                 205             


Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly 
    210                 215                 220                 


Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
225                 230                 235                 240 


Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 
                245                 250                 255     


Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His 
            260                 265                 270         


Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
        275                 280                 285             


Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
    290                 295                 300                 


Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser 
305                 310                 315                 320 


Glu 
    


<210>  57
<211>  1020
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 44, var 4

<400>  57
gatagcccgg atcgcccgtg gaacccgccg acctttagcc cggcgctgct ggtggtgacc       60

gaaggcgata acgcgacctt tacctgcagc tttagcaaca ccagcgaaag ctttgtgctg      120

aactggtatc gcatgagccc gagcaaccag accgataaac tggcggcgtt tccggaagat      180

cgcagccagc cgggccagga ttgccgcttt cgcgtgaccc agctgccgaa cggccgcgat      240

tttcatatga gcgtggtgcg cgcgcgccgc aacgatagcg gcacctatct gtgcggcgcg      300

attagcctgg cgccgaaagc gcagattaaa gaaagcctgc gcgcggaact gcgcgtgacc      360

gaacgccgcg cggaagtgcc gaccgcgcat ccgagcccga gcccgcgccc ggcgggccag      420

ggcagcggcg cgcgcgcgag cccgggcagc gcggcgagcc cgcgcctgcg cgaaggcccg      480

gaactgagcc cggatgatcc ggcgggcctg ctggatctgc gccagggcat gtttgcgcag      540

ctggtggcgc agaacgtgct gctgattgat ggcccgctga gctggtatag cgatccgggc      600

ctggcgggcg tgagcctgac cggcggcctg agctataaag aagataccaa agaactggtg      660

gtggcgaaag cgggcgtgta ttatgtgttt tttcagctgg aactgcgccg cgtggtggcg      720

ggcgaaggca gcggcagcgt gagcctggcg ctgcatctgc agccgctgcg cagcgcggcg      780

ggcgcggcgg cgctggcgct gaccgtggat ctgccgccgg cgagcagcga agcgcgcaac      840

agcgcgtttg gctttcaggg ccgcctgctg catctgagcg cgggccagcg cctgggcgtg      900

catctgcata ccgaagcgcg cgcgcgccat gcgtggcagc tgacccaggg cgcgaccgtg      960

ctgggcctgt ttcgcgtgac cccggaaatt ccggcgggcc tgccgagccc gcgcagcgaa     1020


<210>  58
<211>  999
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 45, var 5

<400>  58
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgccggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctg gatctggcgc tagagcatct      420

cctggctctg ctgcctctcc tagactgaga gagggacctg agctgtctcc tgatgatcct      480

gctggcctgc tggatctgag acagggcatg tttgctcagc tggtggccca gaacgtgctg      540

ctgattgatg gccctctgtc ctggtactct gatcctggat tggctggcgt gtccctgact      600

ggcggcctgt cttacaaaga ggacaccaaa gaactggtgg tggccaaggc cggcgtgtac      660

tacgtgttct ttcagctgga actgcggaga gtggtggccg gcgaaggatc tggatctgtg      720

tctctggcac tgcatctgca gcccctgaga tctgctgcag gcgctgctgc tctggctctg      780

acagttgatc tgcctcctgc ctcctccgag gccagaaact ccgcctttgg cttccaaggc      840

agactgctgc atctgtctgc cggccagaga ctgggagtcc atctgcatac agaggctaga      900

gccaggcacg cctggcagtt gacacaaggt gctacagtgc tgggcctgtt cagagtgacc      960

ccagagattc cagccggcct gccttctcca agatccgag                             999


<210>  59
<211>  975
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 46, var 6

<400>  59
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgccggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctg gatctgctgc ttcccctaga      420

ctgagagagg gccctgagct gtcccctgat gatcctgctg gattgctgga cctgcggcag      480

ggcatgtttg ctcagttggt ggcccagaac gtgctgctga tcgatggccc tctgtcctgg      540

tactctgatc caggattggc tggcgtgtcc ctgactggcg gcctgtctta caaagaggac      600

accaaagaac tggtggtcgc caaggccggc gtgtactacg tgttctttca gctggaactg      660

cggagagtgg tggctggcga aggatctgga tctgtgtctc tggccctgca tctgcagcct      720

ctgagaagtg ctgcaggcgc tgctgcactg gctctgacag ttgatctgcc tcctgcctcc      780

tccgaggcca gaaactccgc ctttggcttc caaggcagac tgctgcatct gtctgccgga      840

cagagactgg gagtgcacct ccatacagag gccagagcta gacacgcttg gcagttgaca      900

cagggcgcta cagtgctggg cctgtttaga gtgacccctg agatcccagc tggcctgcca      960

tctcctagat ctgag                                                       975


<210>  60
<211>  992
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 47, var 7

<400>  60
actctccaga cagaccttgg aaccctccaa ccttctctcc cgctctgctg gtggttaccg       60

agggcgacaa tgccaccttc acctgttcct tcagcaacac ctccgagtcc ttcgtgctga      120

actggtacag aatgtcccct agcaaccaga ccgacaagct ggccgccttt cctgaggaca      180

gatctcagcc aggccaggac tgccggttca gagttaccca gctgcctaac ggccgggact      240

tccacatgtc tgttgtgcgg gccagacgga acgactctgg cacatatctg tgcggcgcca      300

tctctctggc tcccaaggct cagatcaaag agtctctgcg ggccgagctg agagtgacag      360

aaagacgagc tgaggtgccc accgctcatc cctcacctgg agccagagct tctcctggat      420

ctgctgcttc ccctagactg agagagggcc ctgagctgtc ccctgatgat cctgctggat      480

tgctggacct gcggcagggc atgtttgctc agttggtggc ccagaacgtg ctgctgatcg      540

atggccctct gtcctggtac tctgatccag gattggctgg cgtgtccctg actggcggcc      600

tgtcttacaa agaggacacc aaagaactgg tggtcgccaa ggccggcgtg tactacgtgt      660

tctttcagct ggaactgcgg agagtggtgg ctggcgaagg atctggatct gtgtctctgg      720

ccctgcatct gcagcctctg agaagtgctg caggcgctgc tgcactggct ctgacagttg      780

atctgcctcc tgcctcctcc gaggccagaa actccgcctt tggcttccaa ggcagactgc      840

tgcatctgtc tgccggacag agactgggag tgcacctcca tacagaggcc agagctagac      900

acgcttggca gttgacacag ggcgctacag tgctgggcct gtttagagtg acccctgaga      960

tcccagctgg cctgccatct cctagatctg ag                                    992


<210>  61
<211>  956
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 48, var 8

<400>  61
actctccaga cagaccttgg aaccctccaa ccttctctcc cgctctgctg gtggttaccg       60

agggcgacaa tgccaccttc acctgttcct tcagcaacac ctccgagtcc ttcgtgctga      120

actggtacag aatgtcccct agcaaccaga ccgacaagct ggccgccttt cctgaggaca      180

gatctcagcc aggccaggac tgccggttca gagttaccca gctgcctaac ggccgggact      240

tccacatgtc tgttgtgcgg gccagacgga acgactctgg cacatatctg tgcggcgcca      300

tctctctggc tcccaaggct cagatcaaag agtctctgcg ggccgagctg agagtgacag      360

aaagacgagc tgaggtgccc accgctcatc cctcacctgg actgagagag ggccctgagc      420

tgtcccctga tgatcctgct ggattgctgg acctgcggca gggcatgttt gctcagttgg      480

tggcccagaa cgtgctgctg atcgatggcc ctctgtcctg gtactctgat ccaggattgg      540

ctggcgtgtc cctgactggc ggcctgtctt acaaagagga caccaaagaa ctggtggtcg      600

ccaaggccgg cgtgtactac gtgttctttc agctggaact gcggagagtg gtggctggcg      660

aaggatctgg atctgtgtct ctggccctgc atctgcagcc tctgagaagt gctgcaggcg      720

ctgctgcact ggctctgaca gttgatctgc ctcctgcctc ctccgaggcc agaaactccg      780

cctttggctt ccaaggcaga ctgctgcatc tgtctgccgg acagagactg ggagtgcacc      840

tccatacaga ggccagagct agacacgctt ggcagttgac acagggcgct acagtgctgg      900

gcctgtttag agtgacccct gagatcccag ctggcctgcc atctcctaga tctgag          956


<210>  62
<211>  984
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 49, var 9

<400>  62
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactgcc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc acctggatct ggcgctagag catctcctgg ctctgctgcc      420

tctcctagac tgagagaggg acctgagctg tctcctgatg atcctgctgg cctgctggat      480

ctgagacagg gcatgtttgc tcagctggtg gcccagaacg tgctgctgat tgatggccct      540

ctgtcctggt actctgatcc tggattggct ggcgtgtccc tgactggcgg cctgtcttac      600

aaagaggaca ccaaagaact ggtggtggcc aaggccggcg tgtactacgt gttctttcag      660

ctggaactgc ggagagtggt ggccggcgaa ggatctggat ctgtgtctct ggcactgcat      720

ctgcagcccc tgagatctgc tgcaggcgct gctgctctgg ctctgacagt tgatctgcct      780

cctgcctcct ccgaggccag aaactccgcc tttggcttcc aaggcagact gctgcatctg      840

tctgccggcc agagactggg agtccatctg catacagagg ctagagccag gcacgcctgg      900

cagttgacac aaggtgctac agtgctgggc ctgttcagag tgaccccaga gattccagcc      960

ggcctgcctt ctccaagatc cgag                                             984


<210>  63
<211>  960
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 50, var 10

<400>  63
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactgcc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc acctggatct gctgcttccc ctagactgag agagggccct      420

gagctgtccc ctgatgatcc tgctggattg ctggacctgc ggcagggcat gtttgctcag      480

ttggtggccc agaacgtgct gctgatcgat ggccctctgt cctggtactc tgatccagga      540

ttggctggcg tgtccctgac tggcggcctg tcttacaaag aggacaccaa agaactggtg      600

gtcgccaagg ccggcgtgta ctacgtgttc tttcagctgg aactgcggag agtggtggct      660

ggcgaaggat ctggatctgt gtctctggcc ctgcatctgc agcctctgag aagtgctgca      720

ggcgctgctg cactggctct gacagttgat ctgcctcctg cctcctccga ggccagaaac      780

tccgcctttg gcttccaagg cagactgctg catctgtctg ccggacagag actgggagtg      840

cacctccata cagaggccag agctagacac gcttggcagt tgacacaggg cgctacagtg      900

ctgggcctgt ttagagtgac ccctgagatc ccagctggcc tgccatctcc tagatctgag      960


<210>  64
<211>  978
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 51, var 11

<400>  64
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactgcc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc acctggagcc agagcttctc ctggatctgc tgcttcccct      420

agactgagag agggccctga gctgtcccct gatgatcctg ctggattgct ggacctgcgg      480

cagggcatgt ttgctcagtt ggtggcccag aacgtgctgc tgatcgatgg ccctctgtcc      540

tggtactctg atccaggatt ggctggcgtg tccctgactg gcggcctgtc ttacaaagag      600

gacaccaaag aactggtggt cgccaaggcc ggcgtgtact acgtgttctt tcagctggaa      660

ctgcggagag tggtggctgg cgaaggatct ggatctgtgt ctctggccct gcatctgcag      720

cctctgagaa gtgctgcagg cgctgctgca ctggctctga cagttgatct gcctcctgcc      780

tcctccgagg ccagaaactc cgcctttggc ttccaaggca gactgctgca tctgtctgcc      840

ggacagagac tgggagtgca cctccataca gaggccagag ctagacacgc ttggcagttg      900

acacagggcg ctacagtgct gggcctgttt agagtgaccc ctgagatccc agctggcctg      960

ccatctccta gatctgag                                                    978


<210>  65
<211>  942
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 52, var 12

<400>  65
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactgcc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc acctggactg agagagggcc ctgagctgtc ccctgatgat      420

cctgctggat tgctggacct gcggcagggc atgtttgctc agttggtggc ccagaacgtg      480

ctgctgatcg atggccctct gtcctggtac tctgatccag gattggctgg cgtgtccctg      540

actggcggcc tgtcttacaa agaggacacc aaagaactgg tggtcgccaa ggccggcgtg      600

tactacgtgt tctttcagct ggaactgcgg agagtggtgg ctggcgaagg atctggatct      660

gtgtctctgg ccctgcatct gcagcctctg agaagtgctg caggcgctgc tgcactggct      720

ctgacagttg atctgcctcc tgcctcctcc gaggccagaa actccgcctt tggcttccaa      780

ggcagactgc tgcatctgtc tgccggacag agactgggag tgcacctcca tacagaggcc      840

agagctagac acgcttggca gttgacacag ggcgctacag tgctgggcct gtttagagtg      900

acccctgaga tcccagctgg cctgccatct cctagatctg ag                         942


<210>  66
<211>  1005
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 53, var 13

<400>  66
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactgcc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc accttctcca agacctgctg gccagggatc tggcgctaga      420

gcatctcctg gctctgctgc ctctcctaga ctgagagagg gacctgagct gtctcctgat      480

gatcctgctg gcctgctgga tctgagacag ggcatgtttg ctcagctggt ggcccagaac      540

gtgctgctga ttgatggccc tctgtcctgg tactctgatc ctggattggc tggcgtgtcc      600

ctgactggcg gcctgtctta caaagaggac accaaagaac tggtggtggc caaggccggc      660

gtgtactacg tgttctttca gctggaactg cggagagtgg tggccggcga aggatctgga      720

tctgtgtctc tggcactgca tctgcagccc ctgagatctg ctgcaggcgc tgctgctctg      780

gctctgacag ttgatctgcc tcctgcctcc tccgaggcca gaaactccgc ctttggcttc      840

caaggcagac tgctgcatct gtctgccggc cagagactgg gagtccatct gcatacagag      900

gctagagcca ggcacgcctg gcagttgaca caaggtgcta cagtgctggg cctgttcaga      960

gtgaccccag agattccagc cggcctgcct tctccaagat ccgag                     1005


<210>  67
<211>  981
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 54, var 14

<400>  67
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactgcc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc accttctcca agacctgctg gccagggatc tgctgcttcc      420

cctagactga gagagggccc tgagctgtcc cctgatgatc ctgctggatt gctggacctg      480

cggcagggca tgtttgctca gttggtggcc cagaacgtgc tgctgatcga tggccctctg      540

tcctggtact ctgatccagg attggctggc gtgtccctga ctggcggcct gtcttacaaa      600

gaggacacca aagaactggt ggtcgccaag gccggcgtgt actacgtgtt ctttcagctg      660

gaactgcgga gagtggtggc tggcgaagga tctggatctg tgtctctggc cctgcatctg      720

cagcctctga gaagtgctgc aggcgctgct gcactggctc tgacagttga tctgcctcct      780

gcctcctccg aggccagaaa ctccgccttt ggcttccaag gcagactgct gcatctgtct      840

gccggacaga gactgggagt gcacctccat acagaggcca gagctagaca cgcttggcag      900

ttgacacagg gcgctacagt gctgggcctg tttagagtga cccctgagat cccagctggc      960

ctgccatctc ctagatctga g                                                981


<210>  68
<211>  999
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 55, var 15

<400>  68
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactgcc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc accttctcca agacctgctg gccagggagc cagagcttct      420

cctggatctg ctgcttcccc tagactgaga gagggccctg agctgtcccc tgatgatcct      480

gctggattgc tggacctgcg gcagggcatg tttgctcagt tggtggccca gaacgtgctg      540

ctgatcgatg gccctctgtc ctggtactct gatccaggat tggctggcgt gtccctgact      600

ggcggcctgt cttacaaaga ggacaccaaa gaactggtgg tcgccaaggc cggcgtgtac      660

tacgtgttct ttcagctgga actgcggaga gtggtggctg gcgaaggatc tggatctgtg      720

tctctggccc tgcatctgca gcctctgaga agtgctgcag gcgctgctgc actggctctg      780

acagttgatc tgcctcctgc ctcctccgag gccagaaact ccgcctttgg cttccaaggc      840

agactgctgc atctgtctgc cggacagaga ctgggagtgc acctccatac agaggccaga      900

gctagacacg cttggcagtt gacacagggc gctacagtgc tgggcctgtt tagagtgacc      960

cctgagatcc cagctggcct gccatctcct agatctgag                             999


<210>  69
<211>  963
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 56, var 16

<400>  69
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactgcc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc accttctcca agacctgctg gccagggact gagagagggc      420

cctgagctgt cccctgatga tcctgctgga ttgctggacc tgcggcaggg catgtttgct      480

cagttggtgg cccagaacgt gctgctgatc gatggccctc tgtcctggta ctctgatcca      540

ggattggctg gcgtgtccct gactggcggc ctgtcttaca aagaggacac caaagaactg      600

gtggtcgcca aggccggcgt gtactacgtg ttctttcagc tggaactgcg gagagtggtg      660

gctggcgaag gatctggatc tgtgtctctg gccctgcatc tgcagcctct gagaagtgct      720

gcaggcgctg ctgcactggc tctgacagtt gatctgcctc ctgcctcctc cgaggccaga      780

aactccgcct ttggcttcca aggcagactg ctgcatctgt ctgccggaca gagactggga      840

gtgcacctcc atacagaggc cagagctaga cacgcttggc agttgacaca gggcgctaca      900

gtgctgggcc tgtttagagt gacccctgag atcccagctg gcctgccatc tcctagatct      960

gag                                                                    963


<210>  70
<211>  996
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 12

<400>  70
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgccggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgctggccag      420

ggatctgccg cttctcctag actgagagag ggccctgagc tgtctcctga tgatcctgct      480

ggactgctgg acctgagaca gggcatgttt gcccagctgg tggcccagaa tgtgctgctg      540

attgacggcc ctctgtcctg gtactctgat ccaggattgg ctggcgtgtc cctgactggc      600

ggcctgtctt acaaagagga caccaaagaa ctggtggtcg ccaaggccgg cgtgtactac      660

gtgttctttc agctggaact gcggagagtg gtggctggcg aaggatctgg atctgtgtct      720

ctggccctgc atctgcagcc tctgagaagt gctgcaggcg ctgctgcact ggctctgaca      780

gttgatctgc ctcctgcctc ctccgaggcc agaaactccg cctttggctt ccaaggcaga      840

ctgctgcatc tgtctgccgg acagagactg ggagtgcacc tccatacaga ggccagagct      900

agacacgctt ggcagttgac acagggcgct acagtgctgg gcctgtttag agtgacccct      960

gagattccag ccggcctgcc atctccaaga tctgag                                996


<210>  71
<211>  1014
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 14

<400>  71
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgccggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgctggacag      420

ggcgccagag cttctcctgg atctgctgct tcccctagac tgagagaggg ccctgagctg      480

tcccctgatg atcctgctgg attgctggac ctgcggcagg gcatgtttgc tcagttggtg      540

gcccagaacg tgctgctgat cgatggccct ctgtcctggt actctgatcc aggattggct      600

ggcgtgtccc tgactggcgg cctgtcttac aaagaggaca ccaaagaact ggtggtcgcc      660

aaggccggcg tgtactacgt gttctttcag ctggaactgc ggagagtggt ggctggcgaa      720

ggatctggat ctgtgtctct ggccctgcat ctgcagcctc tgagaagtgc tgcaggcgct      780

gctgcactgg ctctgacagt tgatctgcct cctgcctcct ccgaggccag aaactccgcc      840

tttggcttcc aaggcagact gctgcatctg tctgccggac agagactggg agtgcacctc      900

catacagagg ccagagctag acacgcttgg cagttgacac agggcgctac agtgctgggc      960

ctgtttagag tgacccctga gatcccagct ggcctgccat ctcctagatc tgag           1014


<210>  72
<211>  978
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA seq of SEQ ID NO: 16

<400>  72
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgccggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgctggccag      420

ggactgagag agggacctga actgtctcct gatgatcctg ccggcctgct ggatctgaga      480

cagggcatgt ttgcccagct ggtggcccag aatgtgctgc tgattgacgg ccctctgtcc      540

tggtactctg atccaggatt ggctggcgtg tccctgactg gcggcctgtc ttacaaagag      600

gacaccaaag aactggtggt cgccaaggcc ggcgtgtact acgtgttctt tcagctggaa      660

ctgcggagag tggtggctgg cgaaggatct ggatctgtgt ctctggccct gcatctgcag      720

cctctgagaa gtgctgcagg cgctgctgca ctggctctga cagttgatct gcctcctgcc      780

tcctccgagg ccagaaactc cgcctttggc ttccaaggca gactgctgca tctgtctgcc      840

ggacagagac tgggagtgca cctccataca gaggccagag ctagacacgc ttggcagttg      900

acacagggcg ctacagtgct gggcctgttt agagtgaccc ctgagatccc tgctggactg      960

ccctctccaa gatctgag                                                    978


<210>  73
<211>  150
<212>  PRT
<213>  Artificial sequence

<220>
<223>  73  PD1 ECD Full with CYS93>Ser substitution

<400>  73

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  74
<211>  450
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO:73

<400>  74
cccggctggt ttctggactc tccagacaga ccttggaacc ctccaacctt ctctcccgct       60

ctgctggtgg ttaccgaggg cgacaatgcc accttcacct gttccttcag caacacctcc      120

gagtccttcg tgctgaactg gtacagaatg tcccctagca accagaccga caagctggcc      180

gcctttcctg aggacagatc tcagccaggc caggactctc ggttcagagt tacccagctg      240

cctaacggcc gggacttcca catgtctgtt gtgcgggcca gacggaacga ctctggcaca      300

tatctgtgcg gcgccatctc tctggctccc aaggctcaga tcaaagagtc tctgcgggcc      360

gagctgagag tgacagaaag acgagctgag gtgcccaccg ctcatccctc accttctcca      420

agacctgctg gccagtttca gacactcgtg                                       450


<210>  75
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -5-5 from var17 (DSP105 var 1 with CYS93>Ser substitution)

<400>  75

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln 
    130                 135                 140 


<210>  76
<211>  420
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 75  420 bp

<400>  76
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctctcggttc agagtgaccc agctgcctaa cggcagagac      240

ttccacatgt ccgtcgtgcg ggccagaaga aacgactctg gcacctatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgctggccag      420


<210>  77
<211>  146
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -5-5 with His Tag with CYS93>Ser substitution

<400>  77

His His His His His His Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro 
1               5                   10                  15      


Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr 
            20                  25                  30          


Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp 
        35                  40                  45              


Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro 
    50                  55                  60                  


Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln 
65                  70                  75                  80  


Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg 
                85                  90                  95      


Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys 
            100                 105                 110         


Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120                 125             


Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala 
    130                 135                 140                 


Gly Gln 
145     


<210>  78
<211>  438
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO:77  438 bp

<400>  78
caccaccacc atcaccacga ctctccagac agaccttgga accctccaac cttctctccc       60

gctctgctgg tggttaccga gggcgacaat gccaccttca cctgttcctt cagcaacacc      120

tccgagtcct tcgtgctgaa ctggtacaga atgtccccta gcaaccagac cgacaagctg      180

gccgcctttc ctgaggacag atctcagcca ggccaggact ctcggttcag agtgacccag      240

ctgcctaacg gcagagactt ccacatgtcc gtcgtgcggg ccagaagaaa cgactctggc      300

acctatctgt gcggcgccat ctctctggct cccaaggctc agatcaaaga gtctctgcgg      360

gccgagctga gagtgacaga aagacgagct gaggtgccca ccgctcatcc ctcaccttct      420

ccaagacctg ctggccag                                                    438


<210>  79
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -10-5 (with CYS93>Ser substitution)

<400>  79

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


Ser Pro Arg Pro Ala Gly Gln 
    130                 135 


<210>  80
<211>  405
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO:79  405 bp

<400>  80
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactctc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc accttctcca agacctgctg gccag                      405


<210>  81
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -10-12 (with CYS93>Ser substitution)

<400>  81

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
1               5                   10                  15      


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
            20                  25                  30          


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
        35                  40                  45              


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg 
    50                  55                  60                  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
65                  70                  75                  80  


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
                85                  90                  95      


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


<210>  82
<211>  384
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO:81   384 bp

<400>  82
ccttggaacc ctccaacctt ctctcccgct ctgctggtgg ttaccgaggg cgacaatgcc       60

accttcacct gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg      120

tcccctagca accagaccga caagctggcc gcctttcctg aggacagatc tcagccaggc      180

caggactctc ggttcagagt tacccagctg cctaacggcc gggacttcca catgtctgtt      240

gtgcgggcca gacggaacga ctctggcaca tatctgtgcg gcgccatctc tctggctccc      300

aaggctcaga tcaaagagtc tctgcgggcc gagctgagag tgacagaaag acgagctgag      360

gtgcccaccg ctcatccctc acct                                             384


<210>  83
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -5-12 (New, from V20) (with CYS93>Ser substitution)

<400>  83

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro 
    130             


<210>  84
<211>  399
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO:83   399 bp

<400>  84
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctctcggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacct                             399


<210>  85
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -11-12

<400>  85

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
                85                  90                  95      


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125         


<210>  86
<211>  381
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 85   381 bp

<400>  86
tggaaccctc caaccttctc tcccgctctg ctggtggtta ccgagggcga caatgccacc       60

ttcacctgtt ccttcagcaa cacctccgag tccttcgtgc tgaactggta cagaatgtcc      120

cctagcaacc agaccgacaa gctggccgcc tttcctgagg acagatctca gccaggccag      180

gactgtcggt tcagagtgac ccagctgcct aacggcagag acttccacat gtccgtcgtg      240

cgggccagaa gaaacgactc tggcacctat ctgtgcggcg ccatctctct ggctcccaag      300

gctcagatca aagagtctct gcgggccgag ctgagagtga cagaaagacg agctgaggtg      360

cccaccgctc atccctcacc t                                                381


<210>  87
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -11-12 (New, from V18) (with CYS93>Ser substitution)

<400>  87

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
                85                  90                  95      


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125         


<210>  88
<211>  381
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 87   381 bp

<400>  88
tggaaccctc caaccttctc tcccgctctg ctggtggtta ccgagggcga caatgccacc       60

ttcacctgtt ccttcagcaa cacctccgag tccttcgtgc tgaactggta cagaatgtcc      120

cctagcaacc agaccgacaa gctggccgcc tttcctgagg acagatctca gccaggccag      180

gactctcggt tcagagtgac ccagctgcct aacggcagag acttccacat gtccgtcgtg      240

cgggccagaa gaaacgactc tggcacctat ctgtgcggcg ccatctctct ggctcccaag      300

gctcagatca aagagtctct gcgggccgag ctgagagtga cagaaagacg agctgaggtg      360

cccaccgctc atccctcacc t                                                381


<210>  89
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -11-5

<400>  89

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
                85                  90                  95      


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro Arg Pro Ala Gly Gln 
    130                 


<210>  90
<211>  402
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 89   402 bp

<400>  90
tggaaccctc caaccttctc tcccgctctg ctggtggtta ccgagggcga caatgccacc       60

ttcacctgtt ccttcagcaa cacctccgag tccttcgtgc tgaactggta cagaatgtcc      120

cctagcaacc agaccgacaa gctggccgcc tttcctgagg acagatctca gccaggccag      180

gactgtcggt tcagagtgac ccagctgcct aacggcagag acttccacat gtccgtcgtg      240

cgggccagaa gaaacgactc tggcacctat ctgtgcggcg ccatctctct ggctcccaag      300

gctcagatca aagagtctct gcgggccgag ctgagagtga cagaaagacg agctgaggtg      360

cccaccgctc atccctcacc ttctccaaga cctgctggcc ag                         402


<210>  91
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -11-5 (New, from V19) (with CYS93>Ser substitution)

<400>  91

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
                85                  90                  95      


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro Arg Pro Ala Gly Gln 
    130                 


<210>  92
<211>  402
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 91   402 bp

<400>  92
tggaaccctc caaccttctc tcccgctctg ctggtggtta ccgagggcga caatgccacc       60

ttcacctgtt ccttcagcaa cacctccgag tccttcgtgc tgaactggta cagaatgtcc      120

cctagcaacc agaccgacaa gctggccgcc tttcctgagg acagatctca gccaggccag      180

gactctcggt tcagagtgac ccagctgcct aacggcagag acttccacat gtccgtcgtg      240

cgggccagaa gaaacgactc tggcacctat ctgtgcggcg ccatctctct ggctcccaag      300

gctcagatca aagagtctct gcgggccgag ctgagagtga cagaaagacg agctgaggtg      360

cccaccgctc atccctcacc ttctccaaga cctgctggcc ag                         402


<210>  93
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -5-7

<400>  93

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala 
    130                 135             


<210>  94
<211>  414
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 93   414 bp

<400>  94
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgtcggttc agagtgaccc agctgcctaa cggcagagac      240

ttccacatgt ccgtcgtgcg ggccagaaga aacgactctg gcacctatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgct            414


<210>  95
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 -5-7 (New, from V21) (with CYS93>Ser substitution)

<400>  95

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala 
    130                 135             


<210>  96
<211>  414
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 95   414 bp

<400>  96
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctctcggttc agagtgaccc agctgcctaa cggcagagac      240

ttccacatgt ccgtcgtgcg ggccagaaga aacgactctg gcacctatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgct            414


<210>  97
<211>  332
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 var17 (var1 with substitution of CYS93 in the PD1 domain 
       to SER) without His tag

<400>  97

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Gly Ser Ala Ala 
    130                 135                 140                 


Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala 
145                 150                 155                 160 


Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
                165                 170                 175     


Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
            180                 185                 190         


Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
        195                 200                 205             


Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
    210                 215                 220                 


Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
225                 230                 235                 240 


Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                245                 250                 255     


Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
            260                 265                 270         


Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
        275                 280                 285             


Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
    290                 295                 300                 


Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 
305                 310                 315                 320 


Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                325                 330         


<210>  98
<211>  996
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 97   996 bp

<400>  98
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctctcggttc agagtgaccc agctgcctaa cggcagagac      240

ttccacatgt ccgtcgtgcg ggccagaaga aacgactctg gcacctatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgctggccag      420

ggatctgccg cttctcctag actgagagag ggccctgagc tgtctcctga tgatcctgct      480

ggactgctgg acctgagaca gggcatgttt gctcagctgg tggcccagaa cgtgctgctg      540

attgatggcc ctctgtcctg gtactctgat cctggattgg ctggcgtgtc cctgactggc      600

ggcctgtctt acaaagagga caccaaagaa ctggtggtcg ccaaggccgg cgtgtactac      660

gtgttctttc agctggaact gcggagagtg gtggctggcg aaggatctgg atctgtgtct      720

ctggccctgc atctgcagcc tctgagaagt gctgcaggcg ctgctgcact ggctctgaca      780

gttgatctgc ctcctgcctc ctccgaggcc agaaactccg cctttggctt ccaaggcaga      840

ctgctgcatc tgtctgccgg acagagactg ggagtgcacc tccatacaga ggccagagct      900

agacacgctt ggcagttgac acagggcgct acagtgctgg gcctgtttag agtgacacct      960

gagatcccag ccggcctgcc atctccaaga tctgaa                                996


<210>  99
<211>  338
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 var17 (var1 with substitution of CYS93 in the PD1 domain 
       to SER) with His tag

<400>  99

His His His His His His Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro 
1               5                   10                  15      


Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr 
            20                  25                  30          


Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp 
        35                  40                  45              


Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro 
    50                  55                  60                  


Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln 
65                  70                  75                  80  


Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg 
                85                  90                  95      


Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys 
            100                 105                 110         


Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120                 125             


Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala 
    130                 135                 140                 


Gly Gln Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu 
145                 150                 155                 160 


Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe 
                165                 170                 175     


Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser 
            180                 185                 190         


Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
        195                 200                 205             


Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
    210                 215                 220                 


Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu 
225                 230                 235                 240 


Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser 
                245                 250                 255     


Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala 
            260                 265                 270         


Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu 
        275                 280                 285             


His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala 
    290                 295                 300                 


Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly 
305                 310                 315                 320 


Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg 
                325                 330                 335     


Ser Glu 
        


<210>  100
<211>  1014
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 99   1014 bp

<400>  100
caccaccacc atcaccacga ctctccagac agaccttgga accctccaac cttctctccc       60

gctctgctgg tggttaccga gggcgacaat gccaccttca cctgttcctt cagcaacacc      120

tccgagtcct tcgtgctgaa ctggtacaga atgtccccta gcaaccagac cgacaagctg      180

gccgcctttc ctgaggacag atctcagcca ggccaggact ctcggttcag agtgacccag      240

ctgcctaacg gcagagactt ccacatgtcc gtcgtgcggg ccagaagaaa cgactctggc      300

acctatctgt gcggcgccat ctctctggct cccaaggctc agatcaaaga gtctctgcgg      360

gccgagctga gagtgacaga aagacgagct gaggtgccca ccgctcatcc ctcaccttct      420

ccaagacctg ctggccaggg atctgccgct tctcctagac tgagagaggg ccctgagctg      480

tctcctgatg atcctgctgg actgctggac ctgagacagg gcatgtttgc tcagctggtg      540

gcccagaacg tgctgctgat tgatggccct ctgtcctggt actctgatcc tggattggct      600

ggcgtgtccc tgactggcgg cctgtcttac aaagaggaca ccaaagaact ggtggtcgcc      660

aaggccggcg tgtactacgt gttctttcag ctggaactgc ggagagtggt ggctggcgaa      720

ggatctggat ctgtgtctct ggccctgcat ctgcagcctc tgagaagtgc tgcaggcgct      780

gctgcactgg ctctgacagt tgatctgcct cctgcctcct ccgaggccag aaactccgcc      840

tttggcttcc aaggcagact gctgcatctg tctgccggac agagactggg agtgcacctc      900

catacagagg ccagagctag acacgcttgg cagttgacac agggcgctac agtgctgggc      960

ctgtttagag tgacacctga gatcccagcc ggcctgccat ctccaagatc tgaa           1014


<210>  101
<211>  319
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 var18

<400>  101

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
                85                  90                  95      


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Gly 
        115                 120                 125             


Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
    130                 135                 140                 


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
145                 150                 155                 160 


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
                165                 170                 175     


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
            180                 185                 190         


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
        195                 200                 205             


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
    210                 215                 220                 


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
225                 230                 235                 240 


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
                245                 250                 255     


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
            260                 265                 270         


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
        275                 280                 285             


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
    290                 295                 300                 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
305                 310                 315                 


<210>  102
<211>  957
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 101   957 bp

<400>  102
tggaaccctc caaccttctc tcccgctctg ctggtggtta ccgagggcga caatgccacc       60

ttcacctgtt ccttcagcaa cacctccgag tccttcgtgc tgaactggta cagaatgtcc      120

cctagcaacc agaccgacaa gctggccgcc tttcctgagg acagatctca gccaggccag      180

gactctcggt tcagagtgac ccagctgcct aacggcagag acttccacat gtccgtcgtg      240

cgggccagaa gaaacgactc tggcacctat ctgtgcggcg ccatctctct ggctcccaag      300

gctcagatca aagagtctct gcgggccgag ctgagagtga cagaaagacg agctgaggtg      360

cccaccgctc atccctcacc tggatctgcc gcttctccta gactgagaga gggccctgag      420

ctgtctcctg atgatcctgc tggactgctg gacctgagac agggcatgtt tgctcagctg      480

gtggcccaga acgtgctgct gattgatggc cctctgtcct ggtactctga tcctggattg      540

gctggcgtgt ccctgactgg cggcctgtct tacaaagagg acaccaaaga actggtggtc      600

gccaaggccg gcgtgtacta cgtgttcttt cagctggaac tgcggagagt ggtggctggc      660

gaaggatctg gatctgtgtc tctggccctg catctgcagc ctctgagaag tgctgcaggc      720

gctgctgcac tggctctgac agttgatctg cctcctgcct cctccgaggc cagaaactcc      780

gcctttggct tccaaggcag actgctgcat ctgtctgccg gacagagact gggagtgcac      840

ctccatacag aggccagagc tagacacgct tggcagttga cacagggcgc tacagtgctg      900

ggcctgttta gagtgacacc tgagatccca gccggcctgc catctccaag atctgaa         957


<210>  103
<211>  326
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 var19

<400>  103

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
                85                  90                  95      


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro Arg Pro Ala Gly Gln Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu 
    130                 135                 140                 


Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
145                 150                 155                 160 


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                165                 170                 175     


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            180                 185                 190         


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        195                 200                 205             


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    210                 215                 220                 


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
225                 230                 235                 240 


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                245                 250                 255     


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            260                 265                 270         


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        275                 280                 285             


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    290                 295                 300                 


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
305                 310                 315                 320 


Pro Ser Pro Arg Ser Glu 
                325     


<210>  104
<211>  978
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 103   977 bp

<400>  104
tggaaccctc caaccttctc tcccgctctg ctggtggtta ccgagggcga caatgccacc       60

ttcacctgtt ccttcagcaa cacctccgag tccttcgtgc tgaactggta cagaatgtcc      120

cctagcaacc agaccgacaa gctggccgcc tttcctgagg acagatctca gccaggccag      180

gactctcggt tcagagtgac ccagctgcct aacggcagag acttccacat gtccgtcgtg      240

cgggccagaa gaaacgactc tggcacctat ctgtgcggcg ccatctctct ggctcccaag      300

gctcagatca aagagtctct gcgggccgag ctgagagtga cagaaagacg agctgaggtg      360

cccaccgctc atccctcacc ttctccaaga cctgctggcc agggatctgc cgcttctcct      420

agactgagag agggccctga gctgtctcct gatgatcctg ctggactgct ggacctgaga      480

cagggcatgt ttgctcagct ggtggcccag aacgtgctgc tgattgatgg ccctctgtcc      540

tggtactctg atcctggatt ggctggcgtg tccctgactg gcggcctgtc ttacaaagag      600

gacaccaaag aactggtggt cgccaaggcc ggcgtgtact acgtgttctt tcagctggaa      660

ctgcggagag tggtggctgg cgaaggatct ggatctgtgt ctctggccct gcatctgcag      720

cctctgagaa gtgctgcagg cgctgctgca ctggctctga cagttgatct gcctcctgcc      780

tcctccgagg ccagaaactc cgcctttggc ttccaaggca gactgctgca tctgtctgcc      840

ggacagagac tgggagtgca cctccataca gaggccagag ctagacacgc ttggcagttg      900

acacagggcg ctacagtgct gggcctgttt agagtgacac ctgagatccc agccggcctg      960

ccatctccaa gatctgaa                                                    978


<210>  105
<211>  325
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 var20

<400>  105

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
    130                 135                 140                 


Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln 
145                 150                 155                 160 


Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
                165                 170                 175     


Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
            180                 185                 190         


Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
        195                 200                 205             


Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
    210                 215                 220                 


Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
225                 230                 235                 240 


Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
                245                 250                 255     


Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
            260                 265                 270         


Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His 
        275                 280                 285             


Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
    290                 295                 300                 


Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro 
305                 310                 315                 320 


Ser Pro Arg Ser Glu 
                325 


<210>  106
<211>  975
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 105   1062 bp

<400>  106
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctctcggttc agagtgaccc agctgcctaa cggcagagac      240

ttccacatgt ccgtcgtgcg ggccagaaga aacgactctg gcacctatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctg gatctgccgc ttctcctaga      420

ctgagagagg gccctgagct gtctcctgat gatcctgctg gactgctgga cctgagacag      480

ggcatgtttg ctcagctggt ggcccagaac gtgctgctga ttgatggccc tctgtcctgg      540

tactctgatc ctggattggc tggcgtgtcc ctgactggcg gcctgtctta caaagaggac      600

accaaagaac tggtggtcgc caaggccggc gtgtactacg tgttctttca gctggaactg      660

cggagagtgg tggctggcga aggatctgga tctgtgtctc tggccctgca tctgcagcct      720

ctgagaagtg ctgcaggcgc tgctgcactg gctctgacag ttgatctgcc tcctgcctcc      780

tccgaggcca gaaactccgc ctttggcttc caaggcagac tgctgcatct gtctgccgga      840

cagagactgg gagtgcacct ccatacagag gccagagcta gacacgcttg gcagttgaca      900

cagggcgcta cagtgctggg cctgtttaga gtgacacctg agatcccagc cggcctgcca      960

tctccaagat ctgaa                                                       975


<210>  107
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 var21

<400>  107

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Ser Ala Ala Ser Pro 
    130                 135                 140                 


Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
145                 150                 155                 160 


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
                165                 170                 175     


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
            180                 185                 190         


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
        195                 200                 205             


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
    210                 215                 220                 


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
225                 230                 235                 240 


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                245                 250                 255     


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
            260                 265                 270         


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
        275                 280                 285             


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
    290                 295                 300                 


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
305                 310                 315                 320 


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                325                 330 


<210>  108
<211>  990
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 107   1077 bp

<400>  108
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctctcggttc agagtgaccc agctgcctaa cggcagagac      240

ttccacatgt ccgtcgtgcg ggccagaaga aacgactctg gcacctatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgctggatct      420

gccgcttctc ctagactgag agagggccct gagctgtctc ctgatgatcc tgctggactg      480

ctggacctga gacagggcat gtttgctcag ctggtggccc agaacgtgct gctgattgat      540

ggccctctgt cctggtactc tgatcctgga ttggctggcg tgtccctgac tggcggcctg      600

tcttacaaag aggacaccaa agaactggtg gtcgccaagg ccggcgtgta ctacgtgttc      660

tttcagctgg aactgcggag agtggtggct ggcgaaggat ctggatctgt gtctctggcc      720

ctgcatctgc agcctctgag aagtgctgca ggcgctgctg cactggctct gacagttgat      780

ctgcctcctg cctcctccga ggccagaaac tccgcctttg gcttccaagg cagactgctg      840

catctgtctg ccggacagag actgggagtg cacctccata cagaggccag agctagacac      900

gcttggcagt tgacacaggg cgctacagtg ctgggcctgt ttagagtgac acctgagatc      960

ccagccggcc tgccatctcc aagatctgaa                                       990


<210>  109
<211>  362
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 var22 362 aa with His tag

<400>  109

His His His His His His Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg 
1               5                   10                  15      


Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
            20                  25                  30          


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
        35                  40                  45              


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
    50                  55                  60                  


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg 
65                  70                  75                  80  


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
                85                  90                  95      


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
            100                 105                 110         


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
        115                 120                 125             


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
    130                 135                 140                 


Ser Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Gly Ala Cys Pro 
145                 150                 155                 160 


Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro 
                165                 170                 175     


Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
            180                 185                 190         


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
        195                 200                 205             


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
    210                 215                 220                 


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
225                 230                 235                 240 


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
                245                 250                 255     


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
            260                 265                 270         


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
        275                 280                 285             


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
    290                 295                 300                 


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
305                 310                 315                 320 


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
                325                 330                 335     


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
            340                 345                 350         


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        355                 360         


<210>  110
<211>  1086
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 109   1086 bp

<400>  110
caccatcatc accaccatcc tggctggttt ctggacagcc ccgacagacc ttggaaccct       60

cctacattca gccccgctct gctggtggtt accgagggcg ataatgccac cttcacctgt      120

agcttcagca acaccagcga gagcttcgtg ctgaactggt acagaatgag ccccagcaac      180

cagaccgaca agctggccgc ctttcctgag gatagatctc agcccggcca ggactctcgg      240

ttcagagtta cacagctgcc caacggccgg gacttccaca tgtctgtcgt ccgggccaga      300

agaaacgaca gcggcacata tctgtgcggc gccatttctc tggcccctaa ggctcagatc      360

aaagagagcc tgagagccga gctgagagtg acagaaagac gggccgaagt gcccacagct      420

cacccttcac cttctccaag acctgccggc cagtttcaga cactcgtggg agcttgtcct      480

tgggccgttt ctggcgctag agcctctcct ggatctgccg cttctcccag actgagagag      540

ggacctgagc tgagccctga tgatcctgct ggactgctgg atctgagaca gggcatgttt      600

gcccagctgg tggcccagaa tgtgctgctg attgatggcc ctctgtcctg gtacagcgat      660

cctggacttg ctggcgttag cctgactggc ggcctgagct acaaagagga caccaaagaa      720

ctggtggtgg ccaaggccgg cgtgtactac gtgttctttc agctggaact gcggagagtg      780

gtggccggcg aaggatctgg atctgtgtct ctggctctgc atctgcagcc tctgagatct      840

gctgctggtg ctgctgctct ggccctgaca gttgatctgc ctcctgcctc tagcgaggcc      900

agaaactccg cctttggctt ccaaggcaga ctgctgcacc tgagcgctgg acagagactg      960

ggagtccatc tgcacacaga agccagagct agacacgcct ggcagctgac acaaggcgct     1020

acagtgctgg gcctgttcag agtgacccct gagattccag ccggcctgcc atctcctaga     1080

tctgag                                                                1086


<210>  111
<211>  356
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 var22 362 aa

<400>  111

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Gly Ala Cys Pro Trp Ala Val Ser Gly Ala 
145                 150                 155                 160 


Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro 
                165                 170                 175     


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
            180                 185                 190         


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
        195                 200                 205             


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
    210                 215                 220                 


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
225                 230                 235                 240 


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                245                 250                 255     


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
            260                 265                 270         


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
        275                 280                 285             


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
    290                 295                 300                 


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
305                 310                 315                 320 


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
                325                 330                 335     


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser 
            340                 345                 350         


Pro Arg Ser Glu 
        355     


<210>  112
<211>  1068
<212>  DNA
<213>  Artificial sequence

<220>
<223>  na sequence encoding SEQ ID NO: 111   1086 bp

<400>  112
cctggctggt ttctggacag ccccgacaga ccttggaacc ctcctacatt cagccccgct       60

ctgctggtgg ttaccgaggg cgataatgcc accttcacct gtagcttcag caacaccagc      120

gagagcttcg tgctgaactg gtacagaatg agccccagca accagaccga caagctggcc      180

gcctttcctg aggatagatc tcagcccggc caggactctc ggttcagagt tacacagctg      240

cccaacggcc gggacttcca catgtctgtc gtccgggcca gaagaaacga cagcggcaca      300

tatctgtgcg gcgccatttc tctggcccct aaggctcaga tcaaagagag cctgagagcc      360

gagctgagag tgacagaaag acgggccgaa gtgcccacag ctcacccttc accttctcca      420

agacctgccg gccagtttca gacactcgtg ggagcttgtc cttgggccgt ttctggcgct      480

agagcctctc ctggatctgc cgcttctccc agactgagag agggacctga gctgagccct      540

gatgatcctg ctggactgct ggatctgaga cagggcatgt ttgcccagct ggtggcccag      600

aatgtgctgc tgattgatgg ccctctgtcc tggtacagcg atcctggact tgctggcgtt      660

agcctgactg gcggcctgag ctacaaagag gacaccaaag aactggtggt ggccaaggcc      720

ggcgtgtact acgtgttctt tcagctggaa ctgcggagag tggtggccgg cgaaggatct      780

ggatctgtgt ctctggctct gcatctgcag cctctgagat ctgctgctgg tgctgctgct      840

ctggccctga cagttgatct gcctcctgcc tctagcgagg ccagaaactc cgcctttggc      900

ttccaaggca gactgctgca cctgagcgct ggacagagac tgggagtcca tctgcacaca      960

gaagccagag ctagacacgc ctggcagctg acacaaggcg ctacagtgct gggcctgttc     1020

agagtgaccc ctgagattcc agccggcctg ccatctccta gatctgag                  1068


<210>  113
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 var23 amino acid sequence

<400>  113

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Ser Ala Ala Ser Pro 
    130                 135                 140                 


Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
145                 150                 155                 160 


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
                165                 170                 175     


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
            180                 185                 190         


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
        195                 200                 205             


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
    210                 215                 220                 


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
225                 230                 235                 240 


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                245                 250                 255     


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
            260                 265                 270         


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
        275                 280                 285             


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
    290                 295                 300                 


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
305                 310                 315                 320 


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                325                 330 


<210>  114
<211>  990
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DSP105 var23 nucleic acid sequence

<400>  114
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgtcggttc agagtgaccc agctgcctaa cggcagagac      240

ttccacatgt ccgtcgtgcg ggccagaaga aacgactctg gcacctatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgctggatct      420

gccgcttctc ctagactgag agagggccct gagctgtctc ctgatgatcc tgctggactg      480

ctggacctga gacagggcat gtttgctcag ctggtggccc agaacgtgct gctgattgat      540

ggccctctgt cctggtactc tgatcctgga ttggctggcg tgtccctgac tggcggcctg      600

tcttacaaag aggacaccaa agaactggtg gtcgccaagg ccggcgtgta ctacgtgttc      660

tttcagctgg aactgcggag agtggtggct ggcgaaggat ctggatctgt gtctctggcc      720

ctgcatctgc agcctctgag aagtgctgca ggcgctgctg cactggctct gacagttgat      780

ctgcctcctg cctcctccga ggccagaaac tccgcctttg gcttccaagg cagactgctg      840

catctgtctg ccggacagag actgggagtg cacctccata cagaggccag agctagacac      900

gcttggcagt tgacacaggg cgctacagtg ctgggcctgt ttagagtgac acctgagatc      960

ccagccggcc tgccatctcc aagatctgaa                                       990


<210>  115
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 variant amino acid sequence

<400>  115

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg 
    130                 135     


<210>  116
<211>  408
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD1 variant nucleic acid sequence

<400>  116
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgtcggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaaga                   408


<210>  117
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 variant amino acid sequence

<400>  117

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln 
145 


<210>  118
<211>  435
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD1 variant nucleic acid sequence

<400>  118
cccggctggt ttctggactc tccagacaga ccttggaacc ctccaacctt ctctcccgct       60

ctgctggtgg ttaccgaggg cgacaatgcc accttcacct gttccttcag caacacctcc      120

gagtccttcg tgctgaactg gtacagaatg tcccctagca accagaccga caagctggcc      180

gcctttcctg aggacagatc tcagccaggc caggactgtc ggttcagagt tacccagctg      240

cctaacggcc gggacttcca catgtctgtt gtgcgggcca gacggaacga ctctggcaca      300

tatctgtgcg gcgccatctc tctggctccc aaggctcaga tcaaagagtc tctgcgggcc      360

gagctgagag tgacagaaag acgagctgag gtgcccaccg ctcatccctc accttctcca      420

agacctgctg gccag                                                       435


<210>  119
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD1 variant amino acid sequence

<400>  119

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala 
    130                 135                 140             


<210>  120
<211>  429
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD1 variant nucleic acid sequence

<400>  120
cccggctggt ttctggactc tccagacaga ccttggaacc ctccaacctt ctctcccgct       60

ctgctggtgg ttaccgaggg cgacaatgcc accttcacct gttccttcag caacacctcc      120

gagtccttcg tgctgaactg gtacagaatg tcccctagca accagaccga caagctggcc      180

gcctttcctg aggacagatc tcagccaggc caggactgtc ggttcagagt tacccagctg      240

cctaacggcc gggacttcca catgtctgtt gtgcgggcca gacggaacga ctctggcaca      300

tatctgtgcg gcgccatctc tctggctccc aaggctcaga tcaaagagtc tctgcgggcc      360

gagctgagag tgacagaaag acgagctgag gtgcccaccg ctcatccctc accttctcca      420

agacctgct                                                              429


<210>  121
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  121

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  122
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  122

Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   


<210>  123
<211>  184
<212>  PRT
<213>  Artificial sequence

<220>
<223>  4-1BBL variant amino acid sequence

<400>  123

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 


<210>  124
<211>  552
<212>  DNA
<213>  Artificial sequence

<220>
<223>  4-1BBL variant nucleic acid sequence

<400>  124
agagagggcc ctgagctgtc tcctgatgat cctgctggac tgctggacct gagacagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgattg atggccctct gtcctggtac      120

tctgatcctg gattggctgg cgtgtccctg actggcggcc tgtcttacaa agaggacacc      180

aaagaactgg tggtcgccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ctggcgaagg atctggatct gtgtctctgg ccctgcatct gcagcctctg      300

agaagtgctg caggcgctgc tgcactggct ctgacagttg atctgcctcc tgcctcctcc      360

gaggccagaa actccgcctt tggcttccaa ggcagactgc tgcatctgtc tgccggacag      420

agactgggag tgcacctcca tacagaggcc agagctagac acgcttggca gttgacacag      480

ggcgctacag tgctgggcct gtttagagtg acacctgaga tcccagccgg cctgccatct      540

ccaagatctg aa                                                          552


<210>  125
<211>  182
<212>  PRT
<213>  Artificial sequence

<220>
<223>  4-1BBL variant amino acid sequence

<400>  125

Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
1               5                   10                  15      


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
            20                  25                  30          


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
        35                  40                  45              


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
    50                  55                  60                  


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
65                  70                  75                  80  


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
                85                  90                  95      


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
            100                 105                 110         


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
        115                 120                 125             


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
    130                 135                 140                 


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
145                 150                 155                 160 


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
                165                 170                 175     


Pro Ser Pro Arg Ser Glu 
            180         


<210>  126
<211>  546
<212>  DNA
<213>  Artificial sequence

<220>
<223>  4-1BBL variant nucleic acid sequence

<400>  126
ggccctgagc tgtctcctga tgatcctgct ggactgctgg acctgagaca gggcatgttt       60

gctcagctgg tggcccagaa cgtgctgctg attgatggcc ctctgtcctg gtactctgat      120

cctggattgg ctggcgtgtc cctgactggc ggcctgtctt acaaagagga caccaaagaa      180

ctggtggtcg ccaaggccgg cgtgtactac gtgttctttc agctggaact gcggagagtg      240

gtggctggcg aaggatctgg atctgtgtct ctggccctgc atctgcagcc tctgagaagt      300

gctgcaggcg ctgctgcact ggctctgaca gttgatctgc ctcctgcctc ctccgaggcc      360

agaaactccg cctttggctt ccaaggcaga ctgctgcatc tgtctgccgg acagagactg      420

ggagtgcacc tccatacaga ggccagagct agacacgctt ggcagttgac acagggcgct      480

acagtgctgg gcctgtttag agtgacacct gagatcccag ccggcctgcc atctccaaga      540

tctgaa                                                                 546


<210>  127
<211>  183
<212>  PRT
<213>  Artificial sequence

<220>
<223>  4-1BBL variant amino acid sequence

<400>  127

Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
1               5                   10                  15      


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
            20                  25                  30          


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
        35                  40                  45              


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
    50                  55                  60                  


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
65                  70                  75                  80  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
                85                  90                  95      


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
            100                 105                 110         


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
        115                 120                 125             


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
    130                 135                 140                 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
145                 150                 155                 160 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
                165                 170                 175     


Val Thr Pro Glu Ile Pro Ala 
            180             


<210>  128
<211>  551
<212>  DNA
<213>  Artificial sequence

<220>
<223>  4-1BBL variant nucleic acid sequence

<400>  128
gatctgccgc ttctcctaga ctgagagagg gccctgagct gtctcctgat gatcctgctg       60

gactgctgga cctgagacag ggcatgtttg ctcagctggt ggcccagaac gtgctgctga      120

ttgatggccc tctgtcctgg tactctgatc ctggattggc tggcgtgtcc ctgactggcg      180

gcctgtctta caaagaggac accaaagaac tggtggtcgc caaggccggc gtgtactacg      240

tgttctttca gctggaactg cggagagtgg tggctggcga aggatctgga tctgtgtctc      300

tggccctgca tctgcagcct ctgagaagtg ctgcaggcgc tgctgcactg gctctgacag      360

ttgatctgcc tcctgcctcc tccgaggcca gaaactccgc ctttggcttc caaggcagac      420

tgctgcatct gtctgccgga cagagactgg gagtgcacct ccatacagag gccagagcta      480

gacacgcttg gcagttgaca cagggcgcta cagtgctggg cctgtttaga gtgacacctg      540

agatcccagc c                                                           551


<210>  129
<211>  176
<212>  PRT
<213>  Artificial sequence

<220>
<223>  4-1BBL variant amino acid sequence

<400>  129

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


<210>  130
<211>  528
<212>  DNA
<213>  Artificial sequence

<220>
<223>  4-1BBL variant nucleic acid sequence

<400>  130
agagagggcc ctgagctgtc tcctgatgat cctgctggac tgctggacct gagacagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgattg atggccctct gtcctggtac      120

tctgatcctg gattggctgg cgtgtccctg actggcggcc tgtcttacaa agaggacacc      180

aaagaactgg tggtcgccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ctggcgaagg atctggatct gtgtctctgg ccctgcatct gcagcctctg      300

agaagtgctg caggcgctgc tgcactggct ctgacagttg atctgcctcc tgcctcctcc      360

gaggccagaa actccgcctt tggcttccaa ggcagactgc tgcatctgtc tgccggacag      420

agactgggag tgcacctcca tacagaggcc agagctagac acgcttggca gttgacacag      480

ggcgctacag tgctgggcct gtttagagtg acacctgaga tcccagcc                   528


<210>  131
<211>  601
<212>  PRT
<213>  Artificial sequence

<220>
<223>  sc3x4-1BBL -14-0 amino acis sequence

<400>  131

Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
1               5                   10                  15      


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
            20                  25                  30          


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
        35                  40                  45              


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
    50                  55                  60                  


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
65                  70                  75                  80  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
                85                  90                  95      


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
            100                 105                 110         


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
        115                 120                 125             


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
    130                 135                 140                 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
145                 150                 155                 160 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
                165                 170                 175     


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala 
        195                 200                 205             


Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala 
    210                 215                 220                 


Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
225                 230                 235                 240 


Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
                245                 250                 255     


Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
            260                 265                 270         


Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
        275                 280                 285             


Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
    290                 295                 300                 


Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
305                 310                 315                 320 


Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
                325                 330                 335     


Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
            340                 345                 350         


Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
        355                 360                 365             


Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 
    370                 375                 380                 


Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ser Pro Arg 
                405                 410                 415     


Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu 
            420                 425                 430         


Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
        435                 440                 445             


Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
    450                 455                 460                 


Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
465                 470                 475                 480 


Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
                485                 490                 495     


Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
            500                 505                 510         


His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
        515                 520                 525             


Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
    530                 535                 540                 


Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
545                 550                 555                 560 


Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                565                 570                 575     


Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
            580                 585                 590         


Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        595                 600     


<210>  132
<211>  1803
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sc3x4-1BBL -14-0 nucleic acis sequence

<400>  132
tctgccgcca gccctaggct gcgcgaggga cccgagctga gcccagacga tcccgccggc       60

ctgctggacc tgaggcaggg aatgttcgca cagctggtgg cccagaacgt gctgctgatc      120

gacggccctc tgtcctggta ctctgatcca ggcctggccg gcgtgtccct gacaggaggc      180

ctgtcttata aggaggatac caaggagctg gtggtggcaa aggcaggcgt gtactacgtg      240

ttcttccagc tggagctgag gagagtggtg gcaggagagg gcagcggctc cgtgtctctg      300

gccctgcacc tccagcctct gcggagcgcc gccggcgccg ccgccctggc cctgaccgtg      360

gatctgcctc cagccagctc cgaggccagg aatagcgcct tcggctttca gggccgcctg      420

ctgcacctgt ccgccggcca gcggctggga gtgcacctgc acacagaggc cagagcccgg      480

cacgcatggc agctgacaca gggagcaacc gtgctgggcc tgttccgcgt gacccctgag      540

atcccagccg gcctgccaag cccccggtcc gagggcggcg gcggctctgg cggaggaggc      600

agcggaggcg gcggctctgc cgccagcccc aggctgcgcg agggacccga gctgtcccca      660

gacgatcctg ccggcctgct ggacctgcgc cagggaatgt ttgcccagct ggtggctcaa      720

aacgtgctgt taatcgacgg ccctctgagc tggtactctg atcctggcct ggccggcgtg      780

agcctgaccg gcggcctgtc ctacaaagag gatactaaag agctggtggt cgccaaagcc      840

ggcgtgtact acgtgttctt ccaactggag ctgaggaggg tcgtcgccgg cgaaggcagc      900

ggctccgtgt ctctggccct gcacctccag ccgctgagga gcgccgccgg cgccgccgcc      960

ctggccctga cggtggacct gccacctgcc tctagcgagg caagaaattc tgccttcggc     1020

ttccagggca ggctgctgca cctgagcgcc ggccagcgcc tgggcgtcca cctgcatacc     1080

gaagccagag cccggcatgc ctggcagctg acccagggcg ccaccgtgct gggcctgttc     1140

agagtgaccc cagagatccc cgccggcctg cctagcccaa ggtccgaagg cggcggcggc     1200

tccggcggcg gaggctctgg aggagggggc tctgccgcca gcccaaggct gcgcgaggga     1260

cccgagctgt cgcctgacga tccagccggc ctgctggacc tgcgtcaggg catgttcgcc     1320

cagctggtgg ctcagaacgt gctgttaatc gacggcccac tgtcttggta ttctgatccc     1380

ggcctggccg gcgtgtctct gacaggaggc ctgagctaca aagaggatac aaaagagctg     1440

gtggtcgcta aagctggcgt gtactacgtg ttcttccaac tggagctgcg cagggtcgtc     1500

gccggcgagg gcagcggctc cgtgtctctg gccctgcacc tccagccatt acggagcgcc     1560

gccggcgccg ccgccctggc cctgactgtg gacctgccac cagcctcctc tgaggcacgg     1620

aacagcgcct tcggcttcca aggcagactg ctgcacctgt ctgccggcca gaggctgggc     1680

gtccacctgc acaccgaagc cagagcccgg cacgcctggc agctgactca gggcgctacc     1740

gtgctgggcc tgttccgcgt aaccccagag atccctgccg gcctgcccag ccctcggtcc     1800

gag                                                                   1803


<210>  133
<211>  321
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 variant amino acid sequence

<400>  133

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Gly Arg Glu Gly Pro Glu Leu Ser 
    130                 135                 140                 


Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
145                 150                 155                 160 


Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                165                 170                 175     


Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
            180                 185                 190         


Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
        195                 200                 205             


Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly 
    210                 215                 220                 


Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
225                 230                 235                 240 


Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 
                245                 250                 255     


Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His 
            260                 265                 270         


Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
        275                 280                 285             


Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
    290                 295                 300                 


Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser 
305                 310                 315                 320 


Glu 
    


<210>  134
<211>  963
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DSP105 variant nucleic acid sequence

<400>  134
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgtcggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagagg aagagagggc      420

cctgagctgt ctcctgatga tcctgctgga ctgctggacc tgagacaggg catgtttgct      480

cagctggtgg cccagaacgt gctgctgatt gatggccctc tgtcctggta ctctgatcct      540

ggattggctg gcgtgtccct gactggcggc ctgtcttaca aagaggacac caaagaactg      600

gtggtcgcca aggccggcgt gtactacgtg ttctttcagc tggaactgcg gagagtggtg      660

gctggcgaag gatctggatc tgtgtctctg gccctgcatc tgcagcctct gagaagtgct      720

gcaggcgctg ctgcactggc tctgacagtt gatctgcctc ctgcctcctc cgaggccaga      780

aactccgcct ttggcttcca aggcagactg ctgcatctgt ctgccggaca gagactggga      840

gtgcacctcc atacagaggc cagagctaga cacgcttggc agttgacaca gggcgctaca      900

gtgctgggcc tgtttagagt gacacctgag atcccagccg gcctgccatc tccaagatct      960

gaa                                                                    963


<210>  135
<211>  319
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 variant amino acid sequence

<400>  135

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Gly Gly Pro Glu Leu Ser Pro Asp 
    130                 135                 140                 


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
145                 150                 155                 160 


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
                165                 170                 175     


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
            180                 185                 190         


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
        195                 200                 205             


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
    210                 215                 220                 


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
225                 230                 235                 240 


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
                245                 250                 255     


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
            260                 265                 270         


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
        275                 280                 285             


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
    290                 295                 300                 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
305                 310                 315                 


<210>  136
<211>  957
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DSP105 variant nucleic acid sequence

<400>  136
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgtcggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagagg aggccctgag      420

ctgtctcctg atgatcctgc tggactgctg gacctgagac agggcatgtt tgctcagctg      480

gtggcccaga acgtgctgct gattgatggc cctctgtcct ggtactctga tcctggattg      540

gctggcgtgt ccctgactgg cggcctgtct tacaaagagg acaccaaaga actggtggtc      600

gccaaggccg gcgtgtacta cgtgttcttt cagctggaac tgcggagagt ggtggctggc      660

gaaggatctg gatctgtgtc tctggccctg catctgcagc ctctgagaag tgctgcaggc      720

gctgctgcac tggctctgac agttgatctg cctcctgcct cctccgaggc cagaaactcc      780

gcctttggct tccaaggcag actgctgcat ctgtctgccg gacagagact gggagtgcac      840

ctccatacag aggccagagc tagacacgct tggcagttga cacagggcgc tacagtgctg      900

ggcctgttta gagtgacacc tgagatccca gccggcctgc catctccaag atctgaa         957


<210>  137
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 variant amino acid sequence

<400>  137

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser 
145                 150                 155                 160 


Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
                165                 170                 175     


Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
            180                 185                 190         


Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
        195                 200                 205             


Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
    210                 215                 220                 


Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly 
225                 230                 235                 240 


Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
                245                 250                 255     


Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 
            260                 265                 270         


Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His 
        275                 280                 285             


Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
    290                 295                 300                 


Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
305                 310                 315                 320 


Phe Arg Val Thr Pro Glu Ile Pro Ala 
                325                 


<210>  138
<211>  987
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DSP105 variant nucleic acid sequence

<400>  138
cccggctggt ttctggactc tccagacaga ccttggaacc ctccaacctt ctctcccgct       60

ctgctggtgg ttaccgaggg cgacaatgcc accttcacct gttccttcag caacacctcc      120

gagtccttcg tgctgaactg gtacagaatg tcccctagca accagaccga caagctggcc      180

gcctttcctg aggacagatc tcagccaggc caggactgtc ggttcagagt tacccagctg      240

cctaacggcc gggacttcca catgtctgtt gtgcgggcca gacggaacga ctctggcaca      300

tatctgtgcg gcgccatctc tctggctccc aaggctcaga tcaaagagtc tctgcgggcc      360

gagctgagag tgacagaaag acgagctgag gtgcccaccg ctcatccctc accttctcca      420

agacctgctg gccagggatc tgccgcttct cctagactga gagagggccc tgagctgtct      480

cctgatgatc ctgctggact gctggacctg agacagggca tgtttgctca gctggtggcc      540

cagaacgtgc tgctgattga tggccctctg tcctggtact ctgatcctgg attggctggc      600

gtgtccctga ctggcggcct gtcttacaaa gaggacacca aagaactggt ggtcgccaag      660

gccggcgtgt actacgtgtt ctttcagctg gaactgcgga gagtggtggc tggcgaagga      720

tctggatctg tgtctctggc cctgcatctg cagcctctga gaagtgctgc aggcgctgct      780

gcactggctc tgacagttga tctgcctcct gcctcctccg aggccagaaa ctccgccttt      840

ggcttccaag gcagactgct gcatctgtct gccggacaga gactgggagt gcacctccat      900

acagaggcca gagctagaca cgcttggcag ttgacacagg gcgctacagt gctgggcctg      960

tttagagtga cacctgagat cccagcc                                          987


<210>  139
<211>  320
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 variant amino acid sequence

<400>  139

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
145                 150                 155                 160 


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
                165                 170                 175     


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
            180                 185                 190         


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
        195                 200                 205             


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
    210                 215                 220                 


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
225                 230                 235                 240 


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
                245                 250                 255     


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
            260                 265                 270         


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
        275                 280                 285             


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
    290                 295                 300                 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
305                 310                 315                 320 


<210>  140
<211>  960
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DSP105 variant nucleic acid sequence

<400>  140
cccggctggt ttctggactc tccagacaga ccttggaacc ctccaacctt ctctcccgct       60

ctgctggtgg ttaccgaggg cgacaatgcc accttcacct gttccttcag caacacctcc      120

gagtccttcg tgctgaactg gtacagaatg tcccctagca accagaccga caagctggcc      180

gcctttcctg aggacagatc tcagccaggc caggactgtc ggttcagagt tacccagctg      240

cctaacggcc gggacttcca catgtctgtt gtgcgggcca gacggaacga ctctggcaca      300

tatctgtgcg gcgccatctc tctggctccc aaggctcaga tcaaagagtc tctgcgggcc      360

gagctgagag tgacagaaag acgagctgag gtgcccaccg ctcatccctc accttctcca      420

agacctgctg gaagagaggg ccctgagctg tctcctgatg atcctgctgg actgctggac      480

ctgagacagg gcatgtttgc tcagctggtg gcccagaacg tgctgctgat tgatggccct      540

ctgtcctggt actctgatcc tggattggct ggcgtgtccc tgactggcgg cctgtcttac      600

aaagaggaca ccaaagaact ggtggtcgcc aaggccggcg tgtactacgt gttctttcag      660

ctggaactgc ggagagtggt ggctggcgaa ggatctggat ctgtgtctct ggccctgcat      720

ctgcagcctc tgagaagtgc tgcaggcgct gctgcactgg ctctgacagt tgatctgcct      780

cctgcctcct ccgaggccag aaactccgcc tttggcttcc aaggcagact gctgcatctg      840

tctgccggac agagactggg agtgcacctc catacagagg ccagagctag acacgcttgg      900

cagttgacac agggcgctac agtgctgggc ctgtttagag tgacacctga gatcccagcc      960


<210>  141
<211>  346
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 variant amino acid sequence

<400>  141

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Gly Ala Cys Pro 
    130                 135                 140                 


Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro 
145                 150                 155                 160 


Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
                165                 170                 175     


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
            180                 185                 190         


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
        195                 200                 205             


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
    210                 215                 220                 


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
225                 230                 235                 240 


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
                245                 250                 255     


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
            260                 265                 270         


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
        275                 280                 285             


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
    290                 295                 300                 


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
305                 310                 315                 320 


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                325                 330                 335     


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            340                 345     


<210>  142
<211>  1038
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DSP105 variant nucleic acid sequence

<400>  142
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgtcggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgctggccag      420

ggagcctgtc cttgggctgt gtctggcgct agagcatctc ctggctctgc tgcctctcct      480

agactgagag agggacctga gctgtctcct gatgatcctg ctggcctgct ggatctgaga      540

cagggcatgt ttgctcagct ggtggcccag aacgtgctgc tgattgatgg ccctctgtcc      600

tggtactctg atcctggatt ggctggcgtg tccctgactg gcggcctgtc ttacaaagag      660

gacaccaaag aactggtggt ggccaaggcc ggcgtgtact acgtgttctt tcagctggaa      720

ctgcggagag tggtggccgg cgaaggatct ggatctgtgt ctctggcact gcatctgcag      780

cccctgagat ctgctgcagg cgctgctgct ctggctctga cagttgatct gcctcctgcc      840

tcctccgagg ccagaaactc cgcctttggc ttccaaggca gactgctgca tctgtctgcc      900

ggccagagac tgggagtcca tctgcataca gaggctagag ccaggcacgc ctggcagttg      960

acacaaggtg ctacagtgct gggcctgttc agagtgaccc cagagattcc agccggcctg     1020

ccttctccaa gatccgag                                                   1038


<210>  143
<211>  350
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 variant amino acid sequence

<400>  143

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Gly Ser Gly Ala Arg Ala Ser Pro Gly Ser 
145                 150                 155                 160 


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
                165                 170                 175     


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
            180                 185                 190         


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
        195                 200                 205             


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
    210                 215                 220                 


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
225                 230                 235                 240 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
                245                 250                 255     


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
            260                 265                 270         


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
        275                 280                 285             


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
    290                 295                 300                 


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
305                 310                 315                 320 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
                325                 330                 335     


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            340                 345                 350 


<210>  144
<211>  1092
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DSP105 variant nucleic acid sequence

<400>  144
cctggctggt ttctggacag ccccgacaga ccttggaacc ctcctacatt cagccccgct       60

ctgctggtgg ttaccgaggg cgataatgcc accttcacct gtagcttcag caacaccagc      120

gagagcttcg tgctgaactg gtacagaatg agccccagca accagaccga caagctggcc      180

gcctttcctg aggatagatc tcagcccggc caggactgtc ggttcagagt tacacagctg      240

cccaacggcc gggacttcca catgtctgtc gtccgggcca gaagaaacga cagcggcaca      300

tatctgtgcg gcgccatttc tctggcccct aaggctcaga tcaaagagag cctgagagcc      360

gagctgagag tgacagaaag acgggccgaa gtgcccacag ctcacccttc accttctcca      420

agacctgccg gccagtttca gacactcgtg ggagcttgtc cttgggccgt ttctggcgct      480

agagcctctc ctggatctgg cgctagagcc tctcctggat ctgccgcttc tcccagactg      540

agagagggac ctgagctgag ccctgatgat cctgctggac tgctggatct gagacagggc      600

atgtttgccc agctggtggc ccagaatgtg ctgctgattg atggccctct gtcctggtac      660

agcgatcctg gacttgctgg cgttagcctg actggcggcc tgagctacaa agaggacacc      720

aaagaactgg tggtggccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      780

agagtggtgg ccggcgaagg atctggatct gtgtctctgg ctctgcatct gcagcctctg      840

agatctgctg ctggtgctgc tgctctggcc ctgacagttg atctgcctcc tgcctctagc      900

gaggccagaa actccgcctt tggcttccaa ggcagactgc tgcacctgag cgctggacag      960

agactgggag tccatctgca cacagaagcc agagctagac acgcctggca gctgacacaa     1020

ggcgctacag tgctgggcct gttcagagtg acccctgaga ttccagccgg cctgccatct     1080

cctagatctg ag                                                         1092


<210>  145
<211>  365
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 variant amino acid sequence

<400>  145

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
                165                 170                 175     


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            180                 185                 190         


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        195                 200                 205             


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    210                 215                 220                 


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
225                 230                 235                 240 


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                245                 250                 255     


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            260                 265                 270         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        275                 280                 285             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    290                 295                 300                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
305                 310                 315                 320 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                325                 330                 335     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            340                 345                 350         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        355                 360                 365 


<210>  146
<211>  1095
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DSP105 variant nucleic acid sequence

<400>  146
cctggctggt ttctggacag ccccgacaga ccttggaacc ctcctacatt cagccccgct       60

ctgctggtgg ttaccgaggg cgataatgcc accttcacct gtagcttcag caacaccagc      120

gagagcttcg tgctgaactg gtacagaatg agccccagca accagaccga caagctggcc      180

gcctttcctg aggatagatc tcagcccggc caggactgtc ggttcagagt tacacagctg      240

cccaacggcc gggacttcca catgtctgtc gtccgggcca gaagaaacga cagcggcaca      300

tatctgtgcg gcgccatttc tctggcccct aaggctcaga tcaaagagag cctgagagcc      360

gagctgagag tgacagaaag acgggccgaa gtgcccacag ctcacccttc accttctcca      420

agacctgccg gccagtttca gacactcgtg ggaggaggag gatccggagg aggaggatcc      480

gcctgtcctt gggctgtgtc tggcgctaga gcatctcctg gctctgctgc ctctcctaga      540

ctgagagagg gacctgagct gtctcctgat gatcctgctg gcctgctgga tctgagacag      600

ggcatgtttg ctcagctggt ggcccagaac gtgctgctga ttgatggccc tctgtcctgg      660

tactctgatc ctggattggc tggcgtgtcc ctgactggcg gcctgtctta caaagaggac      720

accaaagaac tggtggtggc caaggccggc gtgtactacg tgttctttca gctggaactg      780

cggagagtgg tggccggcga aggatctgga tctgtgtctc tggcactgca tctgcagccc      840

ctgagatctg ctgcaggcgc tgctgctctg gctctgacag ttgatctgcc tcctgcctcc      900

tccgaggcca gaaactccgc ctttggcttc caaggcagac tgctgcatct gtctgccggc      960

cagagactgg gagtccatct gcatacagag gctagagcca ggcacgcctg gcagttgaca     1020

caaggtgcta cagtgctggg cctgttcaga gtgaccccag agattccagc cggcctgcct     1080

tctccaagat ccgag                                                      1095


<210>  147
<211>  750
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105 variant amino acid sequence

<400>  147

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
        115                 120                 125             


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro 
145                 150                 155                 160 


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
                165                 170                 175     


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
            180                 185                 190         


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
        195                 200                 205             


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
    210                 215                 220                 


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
225                 230                 235                 240 


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
                245                 250                 255     


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
            260                 265                 270         


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
        275                 280                 285             


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
    290                 295                 300                 


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
305                 310                 315                 320 


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser 
                325                 330                 335     


Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser 
        355                 360                 365             


Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
    370                 375                 380                 


Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
385                 390                 395                 400 


Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
                405                 410                 415     


Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
            420                 425                 430         


Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly 
        435                 440                 445             


Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
    450                 455                 460                 


Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 
465                 470                 475                 480 


Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His 
                485                 490                 495     


Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
            500                 505                 510         


Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
        515                 520                 525             


Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser 
    530                 535                 540                 


Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
                565                 570                 575     


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
            580                 585                 590         


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
        595                 600                 605             


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
    610                 615                 620                 


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
625                 630                 635                 640 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
                645                 650                 655     


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
            660                 665                 670         


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
        675                 680                 685             


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
    690                 695                 700                 


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
705                 710                 715                 720 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
                725                 730                 735     


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            740                 745                 750 


<210>  148
<211>  2250
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DSP105 variant nucleic acid sequence

<400>  148
gactctccag acagaccttg gaaccctcca accttctctc ccgctctgct ggtggttacc       60

gagggcgaca atgccacctt cacctgttcc ttcagcaaca cctccgagtc cttcgtgctg      120

aactggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcctt tcctgaggac      180

agatctcagc caggccagga ctgtcggttc agagttaccc agctgcctaa cggccgggac      240

ttccacatgt ctgttgtgcg ggccagacgg aacgactctg gcacatatct gtgcggcgcc      300

atctctctgg ctcccaaggc tcagatcaaa gagtctctgc gggccgagct gagagtgaca      360

gaaagacgag ctgaggtgcc caccgctcat ccctcacctt ctccaagacc tgctggccag      420

ggcggcggcg gctccggagg aggaggatct gccgccagcc ctaggctgcg cgagggaccc      480

gagctgagcc cagacgatcc cgccggcctg ctggacctga ggcagggaat gttcgcacag      540

ctggtggccc agaacgtgct gctgatcgac ggccctctgt cctggtactc tgatccaggc      600

ctggccggcg tgtccctgac aggaggcctg tcttataagg aggataccaa ggagctggtg      660

gtggcaaagg caggcgtgta ctacgtgttc ttccagctgg agctgaggag agtggtggca      720

ggagagggca gcggctccgt gtctctggcc ctgcacctcc agcctctgcg gagcgccgcc      780

ggcgccgccg ccctggccct gaccgtggat ctgcctccag ccagctccga ggccaggaat      840

agcgccttcg gctttcaggg ccgcctgctg cacctgtccg ccggccagcg gctgggagtg      900

cacctgcaca cagaggccag agcccggcac gcatggcagc tgacacaggg agcaaccgtg      960

ctgggcctgt tccgcgtgac ccctgagatc ccagccggcc tgccaagccc ccggtccgag     1020

ggcggcggcg gctctggcgg aggaggcagc ggaggcggcg gctctgccgc cagccccagg     1080

ctgcgcgagg gacccgagct gtccccagac gatcctgccg gcctgctgga cctgcgccag     1140

ggaatgtttg cccagctggt ggctcaaaac gtgctgttaa tcgacggccc tctgagctgg     1200

tactctgatc ctggcctggc cggcgtgagc ctgaccggcg gcctgtccta caaagaggat     1260

actaaagagc tggtggtcgc caaagccggc gtgtactacg tgttcttcca actggagctg     1320

aggagggtcg tcgccggcga aggcagcggc tccgtgtctc tggccctgca cctccagccg     1380

ctgaggagcg ccgccggcgc cgccgccctg gccctgacgg tggacctgcc acctgcctct     1440

agcgaggcaa gaaattctgc cttcggcttc cagggcaggc tgctgcacct gagcgccggc     1500

cagcgcctgg gcgtccacct gcataccgaa gccagagccc ggcatgcctg gcagctgacc     1560

cagggcgcca ccgtgctggg cctgttcaga gtgaccccag agatccccgc cggcctgcct     1620

agcccaaggt ccgaaggcgg cggcggctcc ggcggcggag gctctggagg agggggctct     1680

gccgccagcc caaggctgcg cgagggaccc gagctgtcgc ctgacgatcc agccggcctg     1740

ctggacctgc gtcagggcat gttcgcccag ctggtggctc agaacgtgct gttaatcgac     1800

ggcccactgt cttggtattc tgatcccggc ctggccggcg tgtctctgac aggaggcctg     1860

agctacaaag aggatacaaa agagctggtg gtcgctaaag ctggcgtgta ctacgtgttc     1920

ttccaactgg agctgcgcag ggtcgtcgcc ggcgagggca gcggctccgt gtctctggcc     1980

ctgcacctcc agccattacg gagcgccgcc ggcgccgccg ccctggccct gactgtggac     2040

ctgccaccag cctcctctga ggcacggaac agcgccttcg gcttccaagg cagactgctg     2100

cacctgtctg ccggccagag gctgggcgtc cacctgcaca ccgaagccag agcccggcac     2160

gcctggcagc tgactcaggg cgctaccgtg ctgggcctgt tccgcgtaac cccagagatc     2220

cctgccggcc tgcccagccc tcggtccgag                                      2250


<210>  149
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  may repeat 1-4 times

<400>  149

Gly Gly Gly Gly Ser 
1               5   


<210>  150
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  150

Gly Gly Gly Gly Ser 
1               5   


<210>  151
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  151

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  152
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  may repeat 1-3 times

<400>  152

Glu Ala Ala Ala Lys 
1               5   


<210>  153
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence


<220>
<221>  REPEAT
<222>  (2)..(6)
<223>  EAAAK

<220>
<221>  REPEAT
<222>  (2)..(6)
<223>  repeat 2-5 times

<400>  153

Ala Glu Ala Ala Ala Lys Ala 
1               5           


<210>  154
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  154

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  155
<211>  46
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  155

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  156
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  156

Pro Ala Pro Ala Pro 
1               5   


<210>  157
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  157

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  158
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  158

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  159
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  159

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  160
<211>  229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hIgG4 Fc linker

<400>  160

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  161
<211>  229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hIgG4 Fc linker

<400>  161

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Cys Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  162
<211>  229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hIgG4 Fc linker

<400>  162

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Cys Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  163
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hIgG4 Fc linker

<400>  163

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  164
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hIgG4 Fc linker

<400>  164

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  165
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hIgG4 Fc linker

<400>  165

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  166
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker amino acid sequence

<400>  166

Gly Leu Pro Ser Pro Arg Ser Glu 
1               5               


<210>  167
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker amino acid sequence

<400>  167

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu 
            20              


<210>  168
<211>  331
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DSP105_V32 (4-1BBL-PD1 FUSION) amino acid sequence

<400>  168

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
1               5                   10                  15      


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
            20                  25                  30          


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
        35                  40                  45              


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
    50                  55                  60                  


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
65                  70                  75                  80  


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
                85                  90                  95      


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
            100                 105                 110         


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
        115                 120                 125             


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
    130                 135                 140                 


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
145                 150                 155                 160 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
                165                 170                 175     


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Asp 
            180                 185                 190         


Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu 
        195                 200                 205             


Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn 
    210                 215                 220                 


Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn 
225                 230                 235                 240 


Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly 
                245                 250                 255     


Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe 
            260                 265                 270         


His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu 
        275                 280                 285             


Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu 
    290                 295                 300                 


Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala 
305                 310                 315                 320 


His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln 
                325                 330     


<210>  169
<211>  996
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DSP105_V32 (4-1BBL-PD1 FUSION) nucleic acid sequence

<400>  169
tctgccgctt ctcccagact gagagaagga cctgagctga gccctgatga tcctgctgga       60

ctgctggatc tgcggcaggg catgtttgct cagttggtgg cccagaacgt gctgctgatc      120

gatggccctc tgtcctggta ctctgatcca ggattggctg gcgtgtccct gactggcggc      180

ctgtcttaca aagaggacac caaagaactg gtggtggcca aggccggcgt gtactacgtg      240

ttctttcagc tggaactgcg gagagtggtg gctggcgaag gatctggatc tgtgtctctg      300

gccctgcatc tgcagcctct gagaagtgct gcaggcgctg ctgcactggc tctgacagtt      360

gatctgcctc ctgcctcctc cgaggccaga aactccgcct ttggcttcca aggcagactg      420

ctgcacctgt ccgctggaca gagactggga gtccatctgc acacagaggc cagagctaga      480

cacgcttggc agttgacaca gggcgctaca gtgctgggcc tgtttagagt gacccctgag      540

attccagccg gcctgccatc tcctagatct gagggcgact cccctgacag accttggaac      600

cctccaacct tctctcccgc tctgctggtg gttaccgagg gcgacaatgc caccttcacc      660

tgttccttca gcaacacctc cgagtccttc gtgctgaact ggtacagaat gtcccctagc      720

aaccagaccg acaagctggc cgcctttcct gaggacagat ctcagccagg ccaggactgc      780

cggttcagag ttacccagct gcctaacggc cgggacttcc acatgtctgt tgtgcgggcc      840

agacggaacg actctggcac atatctgtgc ggcgccatct ctctggctcc caaggctcag      900

atcaaagagt ctctgcgggc cgagctgaga gtgacagaaa gacgagctga ggtgcccacc      960

gctcatccct caccttctcc aagacctgcc ggccag                                996


