                         SEQUENCE LISTING

<110>  HAV VACCINES LIMITED
 
<120>  VACCINE

<130>  N413293WO

<150>  GB1811382.9
<151>  2018-07-11

<160>  146   

<170>  PatentIn version 3.5

<210>  1
<211>  213
<212>  DNA
<213>  Mycobacterium avium paratuberculosis

<400>  1
atgaccgtga ccgaggtggt ggtggcccag cccgtgtggg ccggcgtgga cgccggcaag       60

gccgaccact actgcatggt gatcaacgac gacgcccaga ggctgctgag ccagagggtg      120

gccaacgacg aggccgccct gctggagctg atcgccgccg tgaccaccct ggccgacggc      180

ggcgaggtga cctgggccat cgacctgaac gcc                                   213


<210>  2
<211>  71
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  2

Met Thr Val Thr Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val 
1               5                   10                  15      


Asp Ala Gly Lys Ala Asp His Tyr Cys Met Val Ile Asn Asp Asp Ala 
            20                  25                  30          


Gln Arg Leu Leu Ser Gln Arg Val Ala Asn Asp Glu Ala Ala Leu Leu 
        35                  40                  45              


Glu Leu Ile Ala Ala Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr 
    50                  55                  60                  


Trp Ala Ile Asp Leu Asn Ala 
65                  70      


<210>  3
<211>  14
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  3

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg 
1               5                   10                  


<210>  4
<211>  26
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  4

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Val Ala 
1               5                   10                  15      


Asn Asp Glu Ala Ala Leu Leu Glu Leu Ile 
            20                  25      


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphorylated A0X short peptide


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  PHOSPHORYLATION

<400>  5

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg 
1               5                   10                  


<210>  6
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphorylated A0X long peptide


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  PHOSPHORYLATION

<400>  6

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Val Ala 
1               5                   10                  15      


Asn Asp Glu Ala Ala Leu Leu Glu Leu Ile 
            20                  25      


<210>  7
<211>  15
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  7

Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr Trp Ala Ile Asp 
1               5                   10                  15  


<210>  8
<211>  18
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  8

Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr Trp Ala Ile Asp Leu 
1               5                   10                  15      


Asn Ala 
        


<210>  9
<211>  20
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  9

Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val Asp Ala Gly Lys 
1               5                   10                  15      


Ala Asp His Tyr 
            20  


<210>  10
<211>  24
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  10

Met Thr Val Thr Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val 
1               5                   10                  15      


Asp Ala Gly Lys Ala Asp His Tyr 
            20                  


<210>  11
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is a peptide linker, A, or AA

<400>  11

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Xaa Val 
1               5                   10                  15      


Thr Thr Leu Ala Asp Gly Gly Glu Val Thr Trp Ala Ile Asp 
            20                  25                  30  


<210>  12
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is a peptide linker, A, or AA

<400>  12

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Xaa Val 
1               5                   10                  15      


Thr Thr Leu Ala Asp Gly Gly Glu Val Thr Trp Ala Ile Asp Leu Asn 
            20                  25                  30          


Ala 
    


<210>  13
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is a peptide linker, A, or AA

<400>  13

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Val Ala 
1               5                   10                  15      


Asn Asp Glu Ala Ala Leu Leu Glu Leu Ile Xaa Val Thr Thr Leu Ala 
            20                  25                  30          


Asp Gly Gly Glu Val Thr Trp Ala Ile Asp 
        35                  40          


<210>  14
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is a peptide linker, A, or AA

<400>  14

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Val Ala 
1               5                   10                  15      


Asn Asp Glu Ala Ala Leu Leu Glu Leu Ile Xaa Val Thr Thr Leu Ala 
            20                  25                  30          


Asp Gly Gly Glu Val Thr Trp Ala Ile Asp Leu Asn Ala 
        35                  40                  45  


<210>  15
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X is a peptide linker or C

<400>  15

Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val Asp Ala Gly Lys 
1               5                   10                  15      


Ala Asp His Tyr Xaa Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu 
            20                  25                  30          


Ser Gln Arg 
        35  


<210>  16
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X is a peptide linker or C

<400>  16

Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val Asp Ala Gly Lys 
1               5                   10                  15      


Ala Asp His Tyr Xaa Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu 
            20                  25                  30          


Ser Gln Arg Val Ala Asn Asp Glu Ala Ala Leu Leu Glu Leu Ile 
        35                  40                  45          


<210>  17
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is a peptide linker or C

<400>  17

Met Thr Val Thr Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val 
1               5                   10                  15      


Asp Ala Gly Lys Ala Asp His Tyr Xaa Met Val Ile Asn Asp Asp Ala 
            20                  25                  30          


Gln Arg Leu Leu Ser Gln Arg 
        35                  


<210>  18
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is a peptide linker or C

<400>  18

Met Thr Val Thr Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val 
1               5                   10                  15      


Asp Ala Gly Lys Ala Asp His Tyr Xaa Met Val Ile Asn Asp Asp Ala 
            20                  25                  30          


Gln Arg Leu Leu Ser Gln Arg Val Ala Asn Asp Glu Ala Ala Leu Leu 
        35                  40                  45              


Glu Leu Ile 
    50      


<210>  19
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X is a peptide linker or C

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  X is a peptide linker, A, or AA

<400>  19

Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val Asp Ala Gly Lys 
1               5                   10                  15      


Ala Asp His Tyr Xaa Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu 
            20                  25                  30          


Ser Gln Arg Val Ala Asn Asp Glu Ala Ala Leu Leu Glu Leu Ile Xaa 
        35                  40                  45              


Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr Trp Ala Ile Asp Leu 
    50                  55                  60                  


Asn Ala 
65      


<210>  20
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is a peptide linker or C

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  X is a peptide linker, A, or AA

<400>  20

Met Thr Val Thr Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val 
1               5                   10                  15      


Asp Ala Gly Lys Ala Asp His Tyr Xaa Met Val Ile Asn Asp Asp Ala 
            20                  25                  30          


Gln Arg Leu Leu Ser Gln Arg Val Ala Asn Asp Glu Ala Ala Leu Leu 
        35                  40                  45              


Glu Leu Ile Xaa Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr Trp 
    50                  55                  60                  


Ala Ile Asp Leu Asn Ala 
65                  70  


<210>  21
<211>  606
<212>  DNA
<213>  Mycobacterium avium paratuberculosis

<400>  21
atgcctctgc tgaccatcgg cgatcagttc cccgcctacg agcttgaccg cgtgatcgcg       60

ggcgacctgt ccaaggtcga cgccaagcag cccggtgact acttcaccac cgtcaccagc      120

gaggaccacg ccggcaagtg gcgcgtggtg ttcttctggc ccaaggactt caccttcgtc      180

tgccccaccg agatcgccac cttcggcaag ctcaacgacg agttcgagga ccgcgacgcc      240

caggtgctcg gcgtctcgat cgacagcgag ttcgtccact tcaactggcg cgcccagcac      300

gaggacctga agaacctgcc gttcccgatg ctctcggaca tcaagcgcga actgagcctg      360

gccaccggtg ttctcaacgc cgacggcgtg gccgaccggg ccaccttcat cgtcgacccg      420

aacaacgaga tccagttcgt ctcggtcacc gcgggttcgg tgggccgcaa cgtcgaggaa      480

gtgctgcggg tgctggatgc gctgcagtcc gacgagctgt gcgcgtgcaa ctggcgcaag      540

ggtgacccga cgctgaacgc caccgaactg ctcaaggcct ctgcttaaaa gggcgaattc      600

gtttaa                                                                 606


<210>  22
<211>  195
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  22

Met Pro Leu Leu Thr Ile Gly Asp Gln Phe Pro Ala Tyr Glu Leu Asp 
1               5                   10                  15      


Arg Val Ile Ala Gly Asp Leu Ser Lys Val Asp Ala Lys Gln Pro Gly 
            20                  25                  30          


Asp Tyr Phe Thr Thr Val Thr Ser Glu Asp His Ala Gly Lys Trp Arg 
        35                  40                  45              


Val Val Phe Phe Trp Pro Lys Asp Phe Thr Phe Val Cys Pro Thr Glu 
    50                  55                  60                  


Ile Ala Thr Phe Gly Lys Leu Asn Asp Glu Phe Glu Asp Arg Asp Ala 
65                  70                  75                  80  


Gln Val Leu Gly Val Ser Ile Asp Ser Glu Phe Val His Phe Asn Trp 
                85                  90                  95      


Arg Ala Gln His Glu Asp Leu Lys Asn Leu Pro Phe Pro Met Leu Ser 
            100                 105                 110         


Asp Ile Lys Arg Glu Leu Ser Leu Ala Thr Gly Val Leu Asn Ala Asp 
        115                 120                 125             


Gly Val Ala Asp Arg Ala Thr Phe Ile Val Asp Pro Asn Asn Glu Ile 
    130                 135                 140                 


Gln Phe Val Ser Val Thr Ala Gly Ser Val Gly Arg Asn Val Glu Glu 
145                 150                 155                 160 


Val Leu Arg Val Leu Asp Ala Leu Gln Ser Asp Glu Leu Cys Ala Cys 
                165                 170                 175     


Asn Trp Arg Lys Gly Asp Pro Thr Leu Asn Ala Thr Glu Leu Leu Lys 
            180                 185                 190         


Ala Ser Ala 
        195 


<210>  23
<211>  801
<212>  DNA
<213>  Mycobacterium avium

<400>  23
atgactgcgc cagtgttctc gataattatc cctaccttca atgcagcggt gacgctgcaa       60

gcctgcctcg gaagcatcgt cgggcagacc taccgggaag tggaagtggt ccttgtcgac      120

ggcggttcga ccgatcggac cctcgacatc gcgaacagtt tccgcccgga actcggctcg      180

cgactggtcg ttcacagcgg gcccgatgat ggcccctacg acgccatgaa ccgcggcgtc      240

ggcgtagcca caggcgaatg ggtacttttt ttaggcgccg acgacaccct ctacgaacca      300

accacgttgg cccaggtagc cgcttttctc ggcgaccatg cggcaagcca tcttgtctat      360

ggcgatgttg tgatgcgttc gacgaaaagc cggcatgccg gacctttcga cctcgaccgc      420

ctcctatttg agacgaattt gtgccaccaa tcgatctttt accgccgtga gcttttcgac      480

ggcatcggcc cttacaacct gcgctaccga gtctgggcgg actgggactt caatattcgc      540

tgcttctcca acccggcgct gattacccgc tacatggacg tcgtgatttc cgaatacaac      600

gacatgaccg gcttcagcat gaggcagggg actgataaag agttcagaaa acggctgcca      660

atgtacttct gggttgcagg gtgggagact tgcaggcgca tgctggcgtt tttgaaagac      720

aaggagaatc gccgtctggc cttgcgtacg cggttgataa gggttaaggc cgtctccaaa      780

gaacgaagcg cagaaccgta g                                                801


<210>  24
<211>  266
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  24

Met Thr Ala Pro Val Phe Ser Ile Ile Ile Pro Thr Phe Asn Ala Ala 
1               5                   10                  15      


Val Thr Leu Gln Ala Cys Leu Gly Ser Ile Val Gly Gln Thr Tyr Arg 
            20                  25                  30          


Glu Val Glu Val Val Leu Val Asp Gly Gly Ser Thr Asp Arg Thr Leu 
        35                  40                  45              


Asp Ile Ala Asn Ser Phe Arg Pro Glu Leu Gly Ser Arg Leu Val Val 
    50                  55                  60                  


His Ser Gly Pro Asp Asp Gly Pro Tyr Asp Ala Met Asn Arg Gly Val 
65                  70                  75                  80  


Gly Val Ala Thr Gly Glu Trp Val Leu Phe Leu Gly Ala Asp Asp Thr 
                85                  90                  95      


Leu Tyr Glu Pro Thr Thr Leu Ala Gln Val Ala Ala Phe Leu Gly Asp 
            100                 105                 110         


His Ala Ala Ser His Leu Val Tyr Gly Asp Val Val Met Arg Ser Thr 
        115                 120                 125             


Lys Ser Arg His Ala Gly Pro Phe Asp Leu Asp Arg Leu Leu Phe Glu 
    130                 135                 140                 


Thr Asn Leu Cys His Gln Ser Ile Phe Tyr Arg Arg Glu Leu Phe Asp 
145                 150                 155                 160 


Gly Ile Gly Pro Tyr Asn Leu Arg Tyr Arg Val Trp Ala Asp Trp Asp 
                165                 170                 175     


Phe Asn Ile Arg Cys Phe Ser Asn Pro Ala Leu Ile Thr Arg Tyr Met 
            180                 185                 190         


Asp Val Val Ile Ser Glu Tyr Asn Asp Met Thr Gly Phe Ser Met Arg 
        195                 200                 205             


Gln Gly Thr Asp Lys Glu Phe Arg Lys Arg Leu Pro Met Tyr Phe Trp 
    210                 215                 220                 


Val Ala Gly Trp Glu Thr Cys Arg Arg Met Leu Ala Phe Leu Lys Asp 
225                 230                 235                 240 


Lys Glu Asn Arg Arg Leu Ala Leu Arg Thr Arg Leu Ile Arg Val Lys 
                245                 250                 255     


Ala Val Ser Lys Glu Arg Ser Ala Glu Pro 
            260                 265     


<210>  25
<211>  417
<212>  DNA
<213>  Mycobacterium avium paratuberculosis

<400>  25
cgatttcgcc gccaccgcca cgccgaaatc atcctgagca tgcccggatt cggcgtcatc       60

ctgggcgctg agttcctcgc cgccaccggc ggggacatgg ccgcattcgc ctccgccgac      120

cgcctcgccg gcgtcgccgg cctggcgccg gtaccacgag attccggccg catcagcgga      180

aacctcaaac gcccccgacg ctacgaccgg cgcctgctgc gcgcctgcta cctgtcggcc      240

ttggtcagca tccgcaccga cccctcctcg cgcacctact acgaccgaaa acgcaccgaa      300

ggaaaacgcc acacccaagc cgtcctcgcc ctggcccgcc gccgcctcaa cgtcctgtgg      360

gccatgctgc gcgaccacgc tgtctaccac cccgcaacca ctaccgcggc ggcttga         417


<210>  26
<211>  138
<212>  PRT
<213>  Mycobacterium avium

<400>  26

Arg Phe Arg Arg His Arg His Ala Glu Ile Ile Leu Ser Met Pro Gly 
1               5                   10                  15      


Phe Gly Val Ile Leu Gly Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp 
            20                  25                  30          


Met Ala Ala Phe Ala Ser Ala Asp Arg Leu Ala Gly Val Ala Gly Leu 
        35                  40                  45              


Ala Pro Val Pro Arg Asp Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg 
    50                  55                  60                  


Pro Arg Arg Tyr Asp Arg Arg Leu Leu Arg Ala Cys Tyr Leu Ser Ala 
65                  70                  75                  80  


Leu Val Ser Ile Arg Thr Asp Pro Ser Ser Arg Thr Tyr Tyr Asp Arg 
                85                  90                  95      


Lys Arg Thr Glu Gly Lys Arg His Thr Gln Ala Val Leu Ala Leu Ala 
            100                 105                 110         


Arg Arg Arg Leu Asn Val Leu Trp Ala Met Leu Arg Asp His Ala Val 
        115                 120                 125             


Tyr His Pro Ala Thr Thr Thr Ala Ala Ala 
    130                 135             


<210>  27
<211>  402
<212>  DNA
<213>  Mycobacterium avium paratuberculosis

<400>  27
cgatttcgcc gccaccgcca cgccgaaatc atcctgagca tgcccggatt cggcgtcatc       60

ctgggcgctg agttcctcgc cgccaccggc ggggacatgg ccgcattcgc ctccgccgac      120

cgcctcgccg gcgtcgccgg cctggcgccg gtaccacgag attccggccg catcagcgga      180

aacctcaaac gcccccgacg ctacgaccgg cgcctgctgc gcgcctgcgt cagcatccgc      240

accgacccct cctcgcgcac ctactacgac cgaaaacgca ccgaaggaaa acgccacacc      300

caagccgtcc tcgccctggc ccgccgccgc ctcaacgtcc tgtgggccat gctgcgcgac      360

cacgctgtct accaccccgc aaccactacc gcggcggctt ga                         402


<210>  28
<211>  133
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  28

Arg Phe Arg Arg His Arg His Ala Glu Ile Ile Leu Ser Met Pro Gly 
1               5                   10                  15      


Phe Gly Val Ile Leu Gly Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp 
            20                  25                  30          


Met Ala Ala Phe Ala Ser Ala Asp Arg Leu Ala Gly Val Ala Gly Leu 
        35                  40                  45              


Ala Pro Val Pro Arg Asp Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg 
    50                  55                  60                  


Pro Arg Arg Tyr Asp Arg Arg Leu Leu Arg Ala Cys Val Ser Ile Arg 
65                  70                  75                  80  


Thr Asp Pro Ser Ser Arg Thr Tyr Tyr Asp Arg Lys Arg Thr Glu Gly 
                85                  90                  95      


Lys Arg His Thr Gln Ala Val Leu Ala Leu Ala Arg Arg Arg Leu Asn 
            100                 105                 110         


Val Leu Trp Ala Met Leu Arg Asp His Ala Val Tyr His Pro Ala Thr 
        115                 120                 125             


Thr Thr Ala Ala Ala 
    130             


<210>  29
<211>  1335
<212>  DNA
<213>  Mycobacterium avium paratuberculosis

<400>  29
gtgactgaag ccaatgagtg caactcggcg tcgcgaaagg tttcagtcgc ggttgagcaa       60

gacaccgcaa gactactgga gtgcgtgcac aagcgccccc agctcgcggc tgaaagcgga      120

tgcaaagggg ttcgaagctt gagcaacatg cgaaggggag aacggcctat gagcctggga      180

caggttttcg acccgcgcgc gaatgcactt aatgcgtggc gcttggtgtt ggcgagcggg      240

gtgatcctat ggcattcgtt tccgctcact ggacgtatgc cgtgggcgcc gttcgtccag      300

ttgcttggcc ttggatgcgt tgatggtttc tttgcggtct ccggctatct catcgtctcg      360

agctggcttc gcaacccgca tcccgcccaa tacttcaccg ctcgatgtct tcgtattctc      420

ccgggtctgt ggatctgtct catcttgacg gcgtttgtca tcgctccgat aggtgtgggc      480

gcccagggcg gttcggccgc gaaactactg atgtccggcg ctccgatcga gtatgtgcta      540

aaagacagtg cggtttggat ggttaagttc gatatcggtg gcacacctcg cgatattcca      600

gttgcgggta tttggaacgg ttctctgtgg acattgggtt gggaggtgct ttgctatatc      660

ggcgtagcag tatttggtat gctcggactt cttagtcgcc gttggttcgt tccagggata      720

ttgatcctgg cgctgtcgtg gtcggtgttc ttgccggcat ggggcggaat acacgcgatc      780

gcctccaatg ctgcgcgatt cgctgtgatg ttttcggccg gagcgttgct gtatcaattc      840

cgtaacgtga ttccggctcg gtggtccttc gttgccgtcg gcctcattat cgttgtggtt      900

tcctctgccg tgctgccgga ctaccggttg gtggcggccc ttccgatggc gtacctaatc      960

atcgcttcgg gttcgctcat ccacaatcaa aggatgaggt tccgcaccga tctatcctat     1020

ggagtatata tttatgcgtt tccaattcag caagtgctgg tcctgtgtgg attcgccgag     1080

ataaatccaa tcgctttctg cgcgatttct gtcgcagcta ttttgccgct cgccgcgctc     1140

agttggttct tggtcgagaa acctgcgttg tcctggaaga gtcgtctccg gcggaaaaac     1200

agttcaattg cgctagccaa tatggaagat ggtggatcag tcggccgctc aaatgacatt     1260

cccggaaggc gggcccgctt tattggcgag aaagccgaag atcctcccgc gccgagccca     1320

agaccggctt tgtaa                                                      1335


<210>  30
<211>  444
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  30

Val Thr Glu Ala Asn Glu Cys Asn Ser Ala Ser Arg Lys Val Ser Val 
1               5                   10                  15      


Ala Val Glu Gln Asp Thr Ala Arg Leu Leu Glu Cys Val His Lys Arg 
            20                  25                  30          


Pro Gln Leu Ala Ala Glu Ser Gly Cys Lys Gly Val Arg Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Arg Gly Glu Arg Pro Met Ser Leu Gly Gln Val Phe Asp 
    50                  55                  60                  


Pro Arg Ala Asn Ala Leu Asn Ala Trp Arg Leu Val Leu Ala Ser Gly 
65                  70                  75                  80  


Val Ile Leu Trp His Ser Phe Pro Leu Thr Gly Arg Met Pro Trp Ala 
                85                  90                  95      


Pro Phe Val Gln Leu Leu Gly Leu Gly Cys Val Asp Gly Phe Phe Ala 
            100                 105                 110         


Val Ser Gly Tyr Leu Ile Val Ser Ser Trp Leu Arg Asn Pro His Pro 
        115                 120                 125             


Ala Gln Tyr Phe Thr Ala Arg Cys Leu Arg Ile Leu Pro Gly Leu Trp 
    130                 135                 140                 


Ile Cys Leu Ile Leu Thr Ala Phe Val Ile Ala Pro Ile Gly Val Gly 
145                 150                 155                 160 


Ala Gln Gly Gly Ser Ala Ala Lys Leu Leu Met Ser Gly Ala Pro Ile 
                165                 170                 175     


Glu Tyr Val Leu Lys Asp Ser Ala Val Trp Met Val Lys Phe Asp Ile 
            180                 185                 190         


Gly Gly Thr Pro Arg Asp Ile Pro Val Ala Gly Ile Trp Asn Gly Ser 
        195                 200                 205             


Leu Trp Thr Leu Gly Trp Glu Val Leu Cys Tyr Ile Gly Val Ala Val 
    210                 215                 220                 


Phe Gly Met Leu Gly Leu Leu Ser Arg Arg Trp Phe Val Pro Gly Ile 
225                 230                 235                 240 


Leu Ile Leu Ala Leu Ser Trp Ser Val Phe Leu Pro Ala Trp Gly Gly 
                245                 250                 255     


Ile His Ala Ile Ala Ser Asn Ala Ala Arg Phe Ala Val Met Phe Ser 
            260                 265                 270         


Ala Gly Ala Leu Leu Tyr Gln Phe Arg Asn Val Ile Pro Ala Arg Trp 
        275                 280                 285             


Ser Phe Val Ala Val Gly Leu Ile Ile Val Val Val Ser Ser Ala Val 
    290                 295                 300                 


Leu Pro Asp Tyr Arg Leu Val Ala Ala Leu Pro Met Ala Tyr Leu Ile 
305                 310                 315                 320 


Ile Ala Ser Gly Ser Leu Ile His Asn Gln Arg Met Arg Phe Arg Thr 
                325                 330                 335     


Asp Leu Ser Tyr Gly Val Tyr Ile Tyr Ala Phe Pro Ile Gln Gln Val 
            340                 345                 350         


Leu Val Leu Cys Gly Phe Ala Glu Ile Asn Pro Ile Ala Phe Cys Ala 
        355                 360                 365             


Ile Ser Val Ala Ala Ile Leu Pro Leu Ala Ala Leu Ser Trp Phe Leu 
    370                 375                 380                 


Val Glu Lys Pro Ala Leu Ser Trp Lys Ser Arg Leu Arg Arg Lys Asn 
385                 390                 395                 400 


Ser Ser Ile Ala Leu Ala Asn Met Glu Asp Gly Gly Ser Val Gly Arg 
                405                 410                 415     


Ser Asn Asp Ile Pro Gly Arg Arg Ala Arg Phe Ile Gly Glu Lys Ala 
            420                 425                 430         


Glu Asp Pro Pro Ala Pro Ser Pro Arg Pro Ala Leu 
        435                 440                 


<210>  31
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimised ahpC

<400>  31
ccccttctca ctatcggaga ccagttcccc gcttacgaac ttacagctct tatcgctgga       60

gatctgagta aggttgacgc caaacagccc ggcgattatt tcactaccgt taccagtgag      120

gatcacgcag gtaaatggag agtcgtcttc ttctggccta aagacttcac ctttgtgtgc      180

cctactgaga tcgcaacatt cgggaagctg aacgatgagt tcgaagatcg agacgcacag      240

gttttgggcg tgtctatcga ttccgagttc gtgcacttca actggagagc acagcatgaa      300

gatctcaaga accttccatt ccccatgctc agcgacatca agagagaact gagcttggca      360

acaggtgttc tgaatgctga tggcgttgct gacagagcaa cattcattgt tgaccccaat      420

aacgagatcc agttcgtttc cgttactgct ggttctgtcg gtagaaacgt tgaagaggtc      480

ctgagagttc tcgacgcact tcagagtgat gaactgtgtg cctgcaattg gcggaaagga      540

gatcctactc tcaatgccac agagctgctt aaagcaagtg ctctc                      585


<210>  32
<211>  195
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  32

Pro Leu Leu Thr Ile Gly Asp Gln Phe Pro Ala Tyr Glu Leu Thr Ala 
1               5                   10                  15      


Leu Ile Ala Gly Asp Leu Ser Lys Val Asp Ala Lys Gln Pro Gly Asp 
            20                  25                  30          


Tyr Phe Thr Thr Val Thr Ser Glu Asp His Ala Gly Lys Trp Arg Val 
        35                  40                  45              


Val Phe Phe Trp Pro Lys Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
    50                  55                  60                  


Ala Thr Phe Gly Lys Leu Asn Asp Glu Phe Glu Asp Arg Asp Ala Gln 
65                  70                  75                  80  


Val Leu Gly Val Ser Ile Asp Ser Glu Phe Val His Phe Asn Trp Arg 
                85                  90                  95      


Ala Gln His Glu Asp Leu Lys Asn Leu Pro Phe Pro Met Leu Ser Asp 
            100                 105                 110         


Ile Lys Arg Glu Leu Ser Leu Ala Thr Gly Val Leu Asn Ala Asp Gly 
        115                 120                 125             


Val Ala Asp Arg Ala Thr Phe Ile Val Asp Pro Asn Asn Glu Ile Gln 
    130                 135                 140                 


Phe Val Ser Val Thr Ala Gly Ser Val Gly Arg Asn Val Glu Glu Val 
145                 150                 155                 160 


Leu Arg Val Leu Asp Ala Leu Gln Ser Asp Glu Leu Cys Ala Cys Asn 
                165                 170                 175     


Trp Arg Lys Gly Asp Pro Thr Leu Asn Ala Thr Glu Leu Leu Lys Ala 
            180                 185                 190         


Ser Ala Leu 
        195 


<210>  33
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Gsd

<400>  33
ggatccattg tcggacagac ctatagagag gtggaagttg tcctggtcga tggtggatct       60

acagatagga ctctcgacat tgccaactcc tttagaccag agctcggttc aaggctcgtt      120

gttcattctg gaccagatga tggaccatac gacgccatga acagaggtgt tggagttgct      180

acaggagaat gggtcttgtt ccttggagct gatgacactc tgtacgaacc gactacattg      240

gctcaggttg cagcattttt gggagatcat gcagcttctc accttgtgta cggagatgtg      300

gtcatgagat ccaccaagtc cagacatgct ggaccattcg atcttgacag actcctgttc      360

gagaccaacc tctgtcatca gagcatcttc tacagacggg aactcttcga cggaattgga      420

ccttacaacc tcaggtacag ggtttgggca gactgggatt tcaacatcag gtgcttctcg      480

aacccagctt tgatcacacg gtacatggat gttgtgatct ccgagtacaa cgatatgacc      540

ggcttctcca tgagacaggg aaccgacaaa gagttcagga agcgcttgcc aatgtacttc      600

tgggttgctg gatgggaaac atgtcggaga atgcttgctt tcctgaagga caaggagaac      660

aggagacttg ctctcaggac tagactcatc agggtcaaag cagtgtccaa ggaaaggagt      720

gctgaacct                                                              729


<210>  34
<211>  243
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  34

Gly Ser Ile Val Gly Gln Thr Tyr Arg Glu Val Glu Val Val Leu Val 
1               5                   10                  15      


Asp Gly Gly Ser Thr Asp Arg Thr Leu Asp Ile Ala Asn Ser Phe Arg 
            20                  25                  30          


Pro Glu Leu Gly Ser Arg Leu Val Val His Ser Gly Pro Asp Asp Gly 
        35                  40                  45              


Pro Tyr Asp Ala Met Asn Arg Gly Val Gly Val Ala Thr Gly Glu Trp 
    50                  55                  60                  


Val Leu Phe Leu Gly Ala Asp Asp Thr Leu Tyr Glu Pro Thr Thr Leu 
65                  70                  75                  80  


Ala Gln Val Ala Ala Phe Leu Gly Asp His Ala Ala Ser His Leu Val 
                85                  90                  95      


Tyr Gly Asp Val Val Met Arg Ser Thr Lys Ser Arg His Ala Gly Pro 
            100                 105                 110         


Phe Asp Leu Asp Arg Leu Leu Phe Glu Thr Asn Leu Cys His Gln Ser 
        115                 120                 125             


Ile Phe Tyr Arg Arg Glu Leu Phe Asp Gly Ile Gly Pro Tyr Asn Leu 
    130                 135                 140                 


Arg Tyr Arg Val Trp Ala Asp Trp Asp Phe Asn Ile Arg Cys Phe Ser 
145                 150                 155                 160 


Asn Pro Ala Leu Ile Thr Arg Tyr Met Asp Val Val Ile Ser Glu Tyr 
                165                 170                 175     


Asn Asp Met Thr Gly Phe Ser Met Arg Gln Gly Thr Asp Lys Glu Phe 
            180                 185                 190         


Arg Lys Arg Leu Pro Met Tyr Phe Trp Val Ala Gly Trp Glu Thr Cys 
        195                 200                 205             


Arg Arg Met Leu Ala Phe Leu Lys Asp Lys Glu Asn Arg Arg Leu Ala 
    210                 215                 220                 


Leu Arg Thr Arg Leu Ile Arg Val Lys Ala Val Ser Lys Glu Arg Ser 
225                 230                 235                 240 


Ala Glu Pro 
            


<210>  35
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimised P12

<400>  35
agaattcgga gacatagaca tgcagagatc atcctgagca tgcctggatt tggcgttatc       60

ctcggagctg aatttcttgc agcaacagga ggtgatatgg cagctttcgc atcagctgac      120

agattggctg gagttgcagg tttggctcca gttccaagag attcagggag aatcagcggt      180

aacctcaaga gacctagacg ctacgacaga agactgctta gagcctgcta tctgagtgct      240

ttggttagca ttagaaccga cccctctagt cgaacctact acgataggaa gcggactgaa      300

ggtaagagac atacccaggc agtgttggca cttgctagaa gacggcttaa tgttctgtgg      360

gctatgctga gagatcatgc cgtgtaccat cctgctacca caacagctgc tgctagactt      420


<210>  36
<211>  140
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  36

Arg Ile Arg Arg His Arg His Ala Glu Ile Ile Leu Ser Met Pro Gly 
1               5                   10                  15      


Phe Gly Val Ile Leu Gly Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp 
            20                  25                  30          


Met Ala Ala Phe Ala Ser Ala Asp Arg Leu Ala Gly Val Ala Gly Leu 
        35                  40                  45              


Ala Pro Val Pro Arg Asp Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg 
    50                  55                  60                  


Pro Arg Arg Tyr Asp Arg Arg Leu Leu Arg Ala Cys Tyr Leu Ser Ala 
65                  70                  75                  80  


Leu Val Ser Ile Arg Thr Asp Pro Ser Ser Arg Thr Tyr Tyr Asp Arg 
                85                  90                  95      


Lys Arg Thr Glu Gly Lys Arg His Thr Gln Ala Val Leu Ala Leu Ala 
            100                 105                 110         


Arg Arg Arg Leu Asn Val Leu Trp Ala Met Leu Arg Asp His Ala Val 
        115                 120                 125             


Tyr His Pro Ala Thr Thr Thr Ala Ala Ala Arg Leu 
    130                 135                 140 


<210>  37
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified P12

<400>  37
agaattcgga gacatagaca tgcagagatc atcctgagca tgcctggatt tggcgttatc       60

ctcggagctg aatttcttgc agcaacagga ggtgatatgg cagctttcgc atcagctgac      120

agattggctg gagttgcagg tttggctcca gttccaagag attcagggag aatcagcggt      180

aacctcaaga gacctagacg ctacgacaga agactgctta gagcctgcgt tagcattaga      240

accgacccct ctagtcgaac ctactacgat aggaagcgga ctgaaggtaa gagacatacc      300

caggcagtgt tggcacttgc tagaagacgg cttaatgttc tgtgggctat gctgagagat      360

catgccgtgt accatcctgc taccacaaca gctgctgcta gactt                      405


<210>  38
<211>  135
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  38

Arg Ile Arg Arg His Arg His Ala Glu Ile Ile Leu Ser Met Pro Gly 
1               5                   10                  15      


Phe Gly Val Ile Leu Gly Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp 
            20                  25                  30          


Met Ala Ala Phe Ala Ser Ala Asp Arg Leu Ala Gly Val Ala Gly Leu 
        35                  40                  45              


Ala Pro Val Pro Arg Asp Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg 
    50                  55                  60                  


Pro Arg Arg Tyr Asp Arg Arg Leu Leu Arg Ala Cys Val Ser Ile Arg 
65                  70                  75                  80  


Thr Asp Pro Ser Ser Arg Thr Tyr Tyr Asp Arg Lys Arg Thr Glu Gly 
                85                  90                  95      


Lys Arg His Thr Gln Ala Val Leu Ala Leu Ala Arg Arg Arg Leu Asn 
            100                 105                 110         


Val Leu Trp Ala Met Leu Arg Asp His Ala Val Tyr His Pro Ala Thr 
        115                 120                 125             


Thr Thr Ala Ala Ala Arg Leu 
    130                 135 


<210>  39
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Mpa

<400>  39
aagcttcgca gaggtgagag acctatgagt cttggccagg tctttgatcc tagagctaat       60

gcactgcact ctttccctct tacaggacgc atgccttggg ctccatttat cgttagttcc      120

tggctcagaa accctcatcc agctcagtac ttcacagcca gatgtctcag aatccttcct      180

ggtctttgga ttggagcaca gggtggttcc gcagctaagc tgttgatgag tggtgcacca      240

atcgaatacg tcctgaaaga ctcagcagtg tggatgttca agttcgacat tggaggaaca      300

ccaagggata ttcctgtcgc tggtatctgg aatggaagtt tgtggacccc agcatgggga      360

ggtattcatg ctatcgcttc caacgcttac cagttccgaa atgtgatccc tgcaagatgg      420

tctgtgagtt cagccgtgtt gccaaactat agacttgttg ctgctctccc catggcctac      480

cataatcagc gaatgaggtt tcggacagat ctgtcctatg gtgtgtacgg gttcgctgaa      540

atcaatccca tcgctctggt tgagaaacct gccctgtctt ggaaatccag actgagacgg      600

aagaactctt ccatcgctct cgcaaacatg gaagatggtg gtagtgttgg aaggagtaac      660

gacatccctg ggaggagggc tagatttatt ggtgagaaag ccgaagatcc tcctgctcca      720

tctcctagac ccgccttg                                                    738


<210>  40
<211>  246
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  40

Lys Leu Arg Arg Gly Glu Arg Pro Met Ser Leu Gly Gln Val Phe Asp 
1               5                   10                  15      


Pro Arg Ala Asn Ala Leu His Ser Phe Pro Leu Thr Gly Arg Met Pro 
            20                  25                  30          


Trp Ala Pro Phe Ile Val Ser Ser Trp Leu Arg Asn Pro His Pro Ala 
        35                  40                  45              


Gln Tyr Phe Thr Ala Arg Cys Leu Arg Ile Leu Pro Gly Leu Trp Ile 
    50                  55                  60                  


Gly Ala Gln Gly Gly Ser Ala Ala Lys Leu Leu Met Ser Gly Ala Pro 
65                  70                  75                  80  


Ile Glu Tyr Val Leu Lys Asp Ser Ala Val Trp Met Phe Lys Phe Asp 
                85                  90                  95      


Ile Gly Gly Thr Pro Arg Asp Ile Pro Val Ala Gly Ile Trp Asn Gly 
            100                 105                 110         


Ser Leu Trp Thr Pro Ala Trp Gly Gly Ile His Ala Ile Ala Ser Asn 
        115                 120                 125             


Ala Tyr Gln Phe Arg Asn Val Ile Pro Ala Arg Trp Ser Val Ser Ser 
    130                 135                 140                 


Ala Val Leu Pro Asn Tyr Arg Leu Val Ala Ala Leu Pro Met Ala Tyr 
145                 150                 155                 160 


His Asn Gln Arg Met Arg Phe Arg Thr Asp Leu Ser Tyr Gly Val Tyr 
                165                 170                 175     


Gly Phe Ala Glu Ile Asn Pro Ile Ala Leu Val Glu Lys Pro Ala Leu 
            180                 185                 190         


Ser Trp Lys Ser Arg Leu Arg Arg Lys Asn Ser Ser Ile Ala Leu Ala 
        195                 200                 205             


Asn Met Glu Asp Gly Gly Ser Val Gly Arg Ser Asn Asp Ile Pro Gly 
    210                 215                 220                 


Arg Arg Ala Arg Phe Ile Gly Glu Lys Ala Glu Asp Pro Pro Ala Pro 
225                 230                 235                 240 


Ser Pro Arg Pro Ala Leu 
                245     


<210>  41
<211>  833
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vaccine polypeptide

<400>  41

Met Gln Ile Phe Val Lys Leu Pro Leu Leu Thr Ile Gly Asp Gln Phe 
1               5                   10                  15      


Pro Ala Tyr Glu Leu Thr Ala Leu Ile Ala Gly Asp Leu Ser Lys Val 
            20                  25                  30          


Asp Ala Lys Gln Pro Gly Asp Tyr Phe Thr Thr Val Thr Ser Glu Asp 
        35                  40                  45              


His Ala Gly Lys Trp Arg Val Val Phe Phe Trp Pro Lys Asp Phe Thr 
    50                  55                  60                  


Gly Pro Glu Ile Ala Thr Phe Gly Lys Leu Asn Asp Glu Phe Glu Asp 
65                  70                  75                  80  


Arg Asp Ala Gln Val Leu Gly Val Ser Ile Asp Ser Glu Phe Val His 
                85                  90                  95      


Phe Asn Trp Arg Ala Gln His Glu Asp Leu Lys Asn Leu Pro Phe Pro 
            100                 105                 110         


Met Leu Ser Asp Ile Lys Arg Glu Leu Ser Leu Ala Thr Gly Val Leu 
        115                 120                 125             


Asn Ala Asp Gly Val Ala Asp Arg Ala Thr Phe Ile Val Asp Pro Asn 
    130                 135                 140                 


Asn Glu Ile Gln Phe Val Ser Val Thr Ala Gly Ser Val Gly Arg Asn 
145                 150                 155                 160 


Val Glu Glu Val Leu Arg Val Leu Asp Ala Leu Gln Ser Asp Glu Leu 
                165                 170                 175     


Cys Ala Cys Asn Trp Arg Lys Gly Asp Pro Thr Leu Asn Ala Thr Glu 
            180                 185                 190         


Leu Leu Lys Ala Ser Ala Leu Gly Ser Ile Val Gly Gln Thr Tyr Arg 
        195                 200                 205             


Glu Val Glu Val Val Leu Val Asp Gly Gly Ser Thr Asp Arg Thr Leu 
    210                 215                 220                 


Asp Ile Ala Asn Ser Phe Arg Pro Glu Leu Gly Ser Arg Leu Val Val 
225                 230                 235                 240 


His Ser Gly Pro Asp Asp Gly Pro Tyr Asp Ala Met Asn Arg Gly Val 
                245                 250                 255     


Gly Val Ala Thr Gly Glu Trp Val Leu Phe Leu Gly Ala Asp Asp Thr 
            260                 265                 270         


Leu Tyr Glu Pro Thr Thr Leu Ala Gln Val Ala Ala Phe Leu Gly Asp 
        275                 280                 285             


His Ala Ala Ser His Leu Val Tyr Gly Asp Val Val Met Arg Ser Thr 
    290                 295                 300                 


Lys Ser Arg His Ala Gly Pro Phe Asp Leu Asp Arg Leu Leu Phe Glu 
305                 310                 315                 320 


Thr Asn Leu Cys His Gln Ser Ile Phe Tyr Arg Arg Glu Leu Phe Asp 
                325                 330                 335     


Gly Ile Gly Pro Tyr Asn Leu Arg Tyr Arg Val Trp Ala Asp Trp Asp 
            340                 345                 350         


Phe Asn Ile Arg Cys Phe Ser Asn Pro Ala Leu Ile Thr Arg Tyr Met 
        355                 360                 365             


Asp Val Val Ile Ser Glu Tyr Asn Asp Met Thr Gly Phe Ser Met Arg 
    370                 375                 380                 


Gln Gly Thr Asp Lys Glu Phe Arg Lys Arg Leu Pro Met Tyr Phe Trp 
385                 390                 395                 400 


Val Ala Gly Trp Glu Thr Cys Arg Arg Met Leu Ala Phe Leu Lys Asp 
                405                 410                 415     


Lys Glu Asn Arg Arg Leu Ala Leu Arg Thr Arg Leu Ile Arg Val Lys 
            420                 425                 430         


Ala Val Ser Lys Glu Arg Ser Ala Glu Pro Arg Ile Arg Arg His Arg 
        435                 440                 445             


His Ala Glu Ile Ile Leu Ser Met Pro Gly Phe Gly Val Ile Leu Gly 
    450                 455                 460                 


Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp Met Ala Ala Phe Ala Ser 
465                 470                 475                 480 


Ala Asp Arg Leu Ala Gly Val Ala Gly Leu Ala Pro Val Pro Arg Asp 
                485                 490                 495     


Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg Pro Arg Arg Tyr Asp Arg 
            500                 505                 510         


Arg Leu Leu Arg Ala Cys Val Ser Ile Arg Thr Asp Pro Ser Ser Arg 
        515                 520                 525             


Thr Tyr Tyr Asp Arg Lys Arg Thr Glu Gly Lys Arg His Thr Gln Ala 
    530                 535                 540                 


Val Leu Ala Leu Ala Arg Arg Arg Leu Asn Val Leu Trp Ala Met Leu 
545                 550                 555                 560 


Arg Asp His Ala Val Tyr His Pro Ala Thr Thr Thr Ala Ala Ala Arg 
                565                 570                 575     


Leu Lys Leu Arg Arg Gly Glu Arg Pro Met Ser Leu Gly Gln Val Phe 
            580                 585                 590         


Asp Pro Arg Ala Asn Ala Leu His Ser Phe Pro Leu Thr Gly Arg Met 
        595                 600                 605             


Pro Trp Ala Pro Phe Ile Val Ser Ser Trp Leu Arg Asn Pro His Pro 
    610                 615                 620                 


Ala Gln Tyr Phe Thr Ala Arg Cys Leu Arg Ile Leu Pro Gly Leu Trp 
625                 630                 635                 640 


Ile Gly Ala Gln Gly Gly Ser Ala Ala Lys Leu Leu Met Ser Gly Ala 
                645                 650                 655     


Pro Ile Glu Tyr Val Leu Lys Asp Ser Ala Val Trp Met Phe Lys Phe 
            660                 665                 670         


Asp Ile Gly Gly Thr Pro Arg Asp Ile Pro Val Ala Gly Ile Trp Asn 
        675                 680                 685             


Gly Ser Leu Trp Thr Pro Ala Trp Gly Gly Ile His Ala Ile Ala Ser 
    690                 695                 700                 


Asn Ala Tyr Gln Phe Arg Asn Val Ile Pro Ala Arg Trp Ser Val Ser 
705                 710                 715                 720 


Ser Ala Val Leu Pro Asn Tyr Arg Leu Val Ala Ala Leu Pro Met Ala 
                725                 730                 735     


Tyr His Asn Gln Arg Met Arg Phe Arg Thr Asp Leu Ser Tyr Gly Val 
            740                 745                 750         


Tyr Gly Phe Ala Glu Ile Asn Pro Ile Ala Leu Val Glu Lys Pro Ala 
        755                 760                 765             


Leu Ser Trp Lys Ser Arg Leu Arg Arg Lys Asn Ser Ser Ile Ala Leu 
    770                 775                 780                 


Ala Asn Met Glu Asp Gly Gly Ser Val Gly Arg Ser Asn Asp Ile Pro 
785                 790                 795                 800 


Gly Arg Arg Ala Arg Phe Ile Gly Glu Lys Ala Glu Asp Pro Pro Ala 
                805                 810                 815     


Pro Ser Pro Arg Pro Ala Leu Arg Ile Pro Asn Pro Leu Leu Gly Leu 
            820                 825                 830         


Asp 
    


<210>  42
<211>  838
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vaccine polypeptide

<400>  42

Met Gln Ile Phe Val Lys Leu Pro Leu Leu Thr Ile Gly Asp Gln Phe 
1               5                   10                  15      


Pro Ala Tyr Glu Leu Thr Ala Leu Ile Ala Gly Asp Leu Ser Lys Val 
            20                  25                  30          


Asp Ala Lys Gln Pro Gly Asp Tyr Phe Thr Thr Val Thr Ser Glu Asp 
        35                  40                  45              


His Ala Gly Lys Trp Arg Val Val Phe Phe Trp Pro Lys Asp Phe Thr 
    50                  55                  60                  


Gly Pro Glu Ile Ala Thr Phe Gly Lys Leu Asn Asp Glu Phe Glu Asp 
65                  70                  75                  80  


Arg Asp Ala Gln Val Leu Gly Val Ser Ile Asp Ser Glu Phe Val His 
                85                  90                  95      


Phe Asn Trp Arg Ala Gln His Glu Asp Leu Lys Asn Leu Pro Phe Pro 
            100                 105                 110         


Met Leu Ser Asp Ile Lys Arg Glu Leu Ser Leu Ala Thr Gly Val Leu 
        115                 120                 125             


Asn Ala Asp Gly Val Ala Asp Arg Ala Thr Phe Ile Val Asp Pro Asn 
    130                 135                 140                 


Asn Glu Ile Gln Phe Val Ser Val Thr Ala Gly Ser Val Gly Arg Asn 
145                 150                 155                 160 


Val Glu Glu Val Leu Arg Val Leu Asp Ala Leu Gln Ser Asp Glu Leu 
                165                 170                 175     


Cys Ala Cys Asn Trp Arg Lys Gly Asp Pro Thr Leu Asn Ala Thr Glu 
            180                 185                 190         


Leu Leu Lys Ala Ser Ala Leu Gly Ser Ile Val Gly Gln Thr Tyr Arg 
        195                 200                 205             


Glu Val Glu Val Val Leu Val Asp Gly Gly Ser Thr Asp Arg Thr Leu 
    210                 215                 220                 


Asp Ile Ala Asn Ser Phe Arg Pro Glu Leu Gly Ser Arg Leu Val Val 
225                 230                 235                 240 


His Ser Gly Pro Asp Asp Gly Pro Tyr Asp Ala Met Asn Arg Gly Val 
                245                 250                 255     


Gly Val Ala Thr Gly Glu Trp Val Leu Phe Leu Gly Ala Asp Asp Thr 
            260                 265                 270         


Leu Tyr Glu Pro Thr Thr Leu Ala Gln Val Ala Ala Phe Leu Gly Asp 
        275                 280                 285             


His Ala Ala Ser His Leu Val Tyr Gly Asp Val Val Met Arg Ser Thr 
    290                 295                 300                 


Lys Ser Arg His Ala Gly Pro Phe Asp Leu Asp Arg Leu Leu Phe Glu 
305                 310                 315                 320 


Thr Asn Leu Cys His Gln Ser Ile Phe Tyr Arg Arg Glu Leu Phe Asp 
                325                 330                 335     


Gly Ile Gly Pro Tyr Asn Leu Arg Tyr Arg Val Trp Ala Asp Trp Asp 
            340                 345                 350         


Phe Asn Ile Arg Cys Phe Ser Asn Pro Ala Leu Ile Thr Arg Tyr Met 
        355                 360                 365             


Asp Val Val Ile Ser Glu Tyr Asn Asp Met Thr Gly Phe Ser Met Arg 
    370                 375                 380                 


Gln Gly Thr Asp Lys Glu Phe Arg Lys Arg Leu Pro Met Tyr Phe Trp 
385                 390                 395                 400 


Val Ala Gly Trp Glu Thr Cys Arg Arg Met Leu Ala Phe Leu Lys Asp 
                405                 410                 415     


Lys Glu Asn Arg Arg Leu Ala Leu Arg Thr Arg Leu Ile Arg Val Lys 
            420                 425                 430         


Ala Val Ser Lys Glu Arg Ser Ala Glu Pro Arg Ile Arg Arg His Arg 
        435                 440                 445             


His Ala Glu Ile Ile Leu Ser Met Pro Gly Phe Gly Val Ile Leu Gly 
    450                 455                 460                 


Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp Met Ala Ala Phe Ala Ser 
465                 470                 475                 480 


Ala Asp Arg Leu Ala Gly Val Ala Gly Leu Ala Pro Val Pro Arg Asp 
                485                 490                 495     


Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg Pro Arg Arg Tyr Asp Arg 
            500                 505                 510         


Arg Leu Leu Arg Ala Cys Tyr Leu Ser Ala Leu Val Ser Ile Arg Thr 
        515                 520                 525             


Asp Pro Ser Ser Arg Thr Tyr Tyr Asp Arg Lys Arg Thr Glu Gly Lys 
    530                 535                 540                 


Arg His Thr Gln Ala Val Leu Ala Leu Ala Arg Arg Arg Leu Asn Val 
545                 550                 555                 560 


Leu Trp Ala Met Leu Arg Asp His Ala Val Tyr His Pro Ala Thr Thr 
                565                 570                 575     


Thr Ala Ala Ala Arg Leu Lys Leu Arg Arg Gly Glu Arg Pro Met Ser 
            580                 585                 590         


Leu Gly Gln Val Phe Asp Pro Arg Ala Asn Ala Leu His Ser Phe Pro 
        595                 600                 605             


Leu Thr Gly Arg Met Pro Trp Ala Pro Phe Ile Val Ser Ser Trp Leu 
    610                 615                 620                 


Arg Asn Pro His Pro Ala Gln Tyr Phe Thr Ala Arg Cys Leu Arg Ile 
625                 630                 635                 640 


Leu Pro Gly Leu Trp Ile Gly Ala Gln Gly Gly Ser Ala Ala Lys Leu 
                645                 650                 655     


Leu Met Ser Gly Ala Pro Ile Glu Tyr Val Leu Lys Asp Ser Ala Val 
            660                 665                 670         


Trp Met Phe Lys Phe Asp Ile Gly Gly Thr Pro Arg Asp Ile Pro Val 
        675                 680                 685             


Ala Gly Ile Trp Asn Gly Ser Leu Trp Thr Pro Ala Trp Gly Gly Ile 
    690                 695                 700                 


His Ala Ile Ala Ser Asn Ala Tyr Gln Phe Arg Asn Val Ile Pro Ala 
705                 710                 715                 720 


Arg Trp Ser Val Ser Ser Ala Val Leu Pro Asn Tyr Arg Leu Val Ala 
                725                 730                 735     


Ala Leu Pro Met Ala Tyr His Asn Gln Arg Met Arg Phe Arg Thr Asp 
            740                 745                 750         


Leu Ser Tyr Gly Val Tyr Gly Phe Ala Glu Ile Asn Pro Ile Ala Leu 
        755                 760                 765             


Val Glu Lys Pro Ala Leu Ser Trp Lys Ser Arg Leu Arg Arg Lys Asn 
    770                 775                 780                 


Ser Ser Ile Ala Leu Ala Asn Met Glu Asp Gly Gly Ser Val Gly Arg 
785                 790                 795                 800 


Ser Asn Asp Ile Pro Gly Arg Arg Ala Arg Phe Ile Gly Glu Lys Ala 
                805                 810                 815     


Glu Asp Pro Pro Ala Pro Ser Pro Arg Pro Ala Leu Arg Ile Pro Asn 
            820                 825                 830         


Pro Leu Leu Gly Leu Asp 
        835             


<210>  43
<211>  406
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  43

Met Thr Val Thr Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val 
1               5                   10                  15      


Asp Ala Gly Lys Ala Asp His Tyr Cys Met Val Ile Asn Asp Asp Ala 
            20                  25                  30          


Gln Arg Leu Leu Ser Gln Arg Val Ala Asn Asp Glu Ala Ala Leu Leu 
        35                  40                  45              


Glu Leu Ile Ala Ala Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr 
    50                  55                  60                  


Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly Arg Thr Val 
                85                  90                  95      


His His Ala Ala Gly Ser Tyr Arg Gly Glu Gly Lys Thr Asp Ala Lys 
            100                 105                 110         


Asp Ala Ala Ile Ile Ala Asp Gln Ala Arg Met Arg His Asp Leu Gln 
        115                 120                 125             


Pro Leu Arg Ala Gly Asp Asp Ile Ala Val Glu Leu Arg Ile Leu Thr 
    130                 135                 140                 


Ser Arg Arg Ser Asp Leu Val Ala Asp Arg Thr Arg Ala Ile Asn Arg 
145                 150                 155                 160 


Met Arg Ala Gln Leu Leu Glu Tyr Phe Pro Ala Leu Glu Arg Ala Phe 
                165                 170                 175     


Asp Tyr Asn Lys Ser Arg Ala Ala Leu Ile Leu Leu Thr Gly Tyr Gln 
            180                 185                 190         


Thr Pro Asp Ala Leu Arg Ser Ala Gly Gly Ala Arg Val Ala Ala Phe 
        195                 200                 205             


Leu Arg Lys Arg Lys Ala Arg Asn Ala Asp Thr Val Ala Ala Thr Ala 
    210                 215                 220                 


Leu Gln Ala Ala Asn Ala Gln His Ser Ile Val Pro Gly Gln Gln Leu 
225                 230                 235                 240 


Ala Ala Thr Val Val Ala Arg Leu Ala Lys Glu Val Met Ala Leu Asp 
                245                 250                 255     


Thr Glu Ile Gly Asp Thr Asp Ala Met Ile Glu Glu Arg Phe Arg Arg 
            260                 265                 270         


His Arg His Ala Glu Ile Ile Leu Ser Met Pro Gly Phe Gly Val Ile 
        275                 280                 285             


Leu Gly Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp Met Ala Ala Phe 
    290                 295                 300                 


Ala Ser Ala Asp Arg Leu Ala Gly Val Ala Gly Leu Ala Pro Val Pro 
305                 310                 315                 320 


Arg Asp Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg Pro Arg Arg Tyr 
                325                 330                 335     


Asp Arg Arg Leu Leu Arg Ala Cys Tyr Leu Ser Ala Leu Val Ser Ile 
            340                 345                 350         


Arg Thr Asp Pro Ser Ser Arg Thr Tyr Tyr Asp Arg Lys Arg Thr Glu 
        355                 360                 365             


Gly Lys Arg His Thr Gln Ala Val Leu Ala Leu Ala Arg Arg Arg Leu 
    370                 375                 380                 


Asn Val Leu Trp Ala Met Leu Arg Asp His Ala Val Tyr His Pro Ala 
385                 390                 395                 400 


Thr Thr Thr Ala Ala Ala 
                405     


<210>  44
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  44

Val Ser Ile Arg Thr Asp Pro Ser Ser Arg 
1               5                   10  


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphorylated A4 peptide


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<400>  45

Val Ser Ile Arg Thr Asp Pro Ser Ser Arg 
1               5                   10  


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphorylated A4 peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  PHOSPHORYLATION

<400>  46

Val Ser Ile Arg Thr Asp Pro Ser Ser Arg 
1               5                   10  


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphorylated A4 peptide


<220>
<221>  MOD_RES
<222>  (8)..(9)
<223>  PHOSPHORYLATION

<400>  47

Val Ser Ile Arg Thr Asp Pro Ser Ser Arg 
1               5                   10  


<210>  48
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  48

Asn Leu Lys Arg Pro Arg Arg Tyr Asp Arg 
1               5                   10  


<210>  49
<211>  2522
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vaccine polynucleotide sequence

<400>  49
atgcagatct tcgtcaaact gccccttctc actatcggag accagttccc cgcttacgaa       60

cttacagctc ttatcgctgg agatctgagt aaggttgacg ccaaacagcc cggcgattat      120

ttcactaccg ttaccagtga ggatcacgca ggtaaatgga gagtcgtctt cttctggcct      180

aaagacttca cctttgtgtg ccctactgag atcgcaacat tcgggaagct gaacgatgag      240

ttcgaagatc gagacgcaca ggttttgggc gtgtctatcg attccgagtt cgtgcacttc      300

aactggagag cacagcatga agatctcaag aaccttccat tccccatgct cagcgacatc      360

aagagagaac tgagcttggc aacaggtgtt ctgaatgctg atggcgttgc tgacagagca      420

acattcattg ttgaccccaa taacgagatc cagttcgttt ccgttactgc tggttctgtc      480

ggtagaaacg ttgaagaggt cctgagagtt ctcgacgcac ttcagagtga tgaactgtgt      540

gcctgcaatt ggcggaaagg agatcctact ctcaatgcca cagagctgct taaagcaagt      600

gctctcggat ccattgtcgg acagacctat agagaggtgg aagttgtcct ggtcgatggt      660

ggatctacag ataggactct cgacattgcc aactccttta gaccagagct cggttcaagg      720

ctcgttgttc attctggacc agatgatgga ccatacgacg ccatgaacag aggtgttgga      780

gttgctacag gagaatgggt cttgttcctt ggagctgatg acactctgta cgaaccgact      840

acattggctc aggttgcagc atttttggga gatcatgcag cttctcacct tgtgtacgga      900

gatgtggtca tgagatccac caagtccaga catgctggac cattcgatct tgacagactc      960

ctgttcgaga ccaacctctg tcatcagagc atcttctaca gacgggaact cttcgacgga     1020

attggacctt acaacctcag gtacagggtt tgggcagact gggatttcaa catcaggtgc     1080

ttctcgaacc cagctttgat cacacggtac atggatgttg tgatctccga gtacaacgat     1140

atgaccggct tctccatgag acagggaacc gacaaagagt tcaggaagcg cttgccaatg     1200

tacttctggg ttgctggatg ggaaacatgt cggagaatgc ttgctttcct gaaggacaag     1260

gagaacagga gacttgctct caggactaga ctcatcaggg tcaaagcagt gtccaaggaa     1320

aggagtgctg aacctagaat tcggagacat agacatgcag agatcatcct gagcatgcct     1380

ggatttggcg ttatcctcgg agctgaattt cttgcagcaa caggaggtga tatggcagct     1440

ttcgcatcag ctgacagatt ggctggagtt gcaggtttgg ctccagttcc aagagattca     1500

gggagaatca gcggtaacct caagagacct agacgctacg acagaagact gcttagagcc     1560

tgctatctga gtgctttggt tagcattaga accgacccct ctagtcgaac ctactacgat     1620

aggaagcgga ctgaaggtaa gagacatacc caggcagtgt tggcacttgc tagaagacgg     1680

cttaatgttc tgtgggctat gctgagagat catgccgtgt accatcctgc taccacaaca     1740

gctgctgcta gacttaagct tcgcagaggt gagagaccta tgagtcttgg ccaggtcttt     1800

gatcctagag ctaatgcact gcactctttc cctcttacag gacgcatgcc ttgggctcca     1860

tttatcgtta gttcctggct cagaaaccct catccagctc agtacttcac agccagatgt     1920

ctcagaatcc ttcctggtct ttggattgga gcacagggtg gttccgcagc taagctgttg     1980

atgagtggtg caccaatcga atacgtcctg aaagactcag cagtgtggat gttcaagttc     2040

gacattggag gaacaccaag ggatattcct gtcgctggta tctggaatgg aagtttgtgg     2100

accccagcat ggggaggtat tcatgctatc gcttccaacg cttaccagtt ccgaaatgtg     2160

atccctgcaa gatggtctgt gagttcagcc gtgttgccaa actatagact tgttgctgct     2220

ctccccatgg cctaccataa tcagcgaatg aggtttcgga cagatctgtc ctatggtgtg     2280

tacgggttcg ctgaaatcaa tcccatcgct ctggttgaga aacctgccct gtcttggaaa     2340

tccagactga gacggaagaa ctcttccatc gctctcgcaa acatggaaga tggtggtagt     2400

gttggaagga gtaacgacat ccctgggagg agggctagat ttattggtga gaaagccgaa     2460

gatcctcctg ctccatctcc tagacccgcc ttgaggattc caaaccctct tctcggtctt     2520

ga                                                                    2522


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  50

Val Asp Ala Gly Lys Ala Asp His Tyr 
1               5                   


<210>  51
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Met Thr Val Thr Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val 
1               5                   10                  15      


Asp Ala Gly Lys Ala Asp His Tyr Cys Met Val Ile Asn Asp Asp Ala 
            20                  25                  30          


Gln Arg Leu Leu Ser Gln Arg Val Ala Asn Asp Glu Ala Ala Leu Leu 
        35                  40                  45              


Glu Leu Ile Ala Ala Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr 
    50                  55                  60                  


Trp Ala Ile Asp 
65              


<210>  52
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Val Asp 
1               5                   10                  15      


Ala Gly Lys Ala Asp His Tyr Ala Val Thr Thr Leu Ala Asp Gly Gly 
            20                  25                  30          


Glu Val Thr Trp Ala Ile Asp 
        35                  


<210>  53
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Leu Asn Ala Gly Gly Ala Ala Leu Leu Ile Ala Leu Leu Ile Ala Ala 
1               5                   10                  15      


Gly Gln Arg Leu Leu Tyr 
            20          


<210>  54
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  54

Ile Pro Gly Arg Thr Val His His Ala Ala Gly Ser Tyr Arg Gly Glu 
1               5                   10                  15      


<210>  55
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  55

Ile Pro Gly Ala Thr Val His His Ala Ala Gly Ser Tyr Arg Gly Glu 
1               5                   10                  15      


<210>  56
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  56

Leu Asn Ala Gly Gly Ala Ala Leu Leu Ile Ala Leu Leu Ile Ala Ala 
1               5                   10                  15      


Gly Gln Arg Leu Leu Tyr Ile Pro Gly Arg Thr Val His His Ala Ala 
            20                  25                  30          


Gly Ser Tyr Arg Gly Glu 
        35              


<210>  57
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Leu Asn Ala Gly Gly Ala Ala Leu Leu Ile Ala Leu Leu Ile Ala Ala 
1               5                   10                  15      


Gly Gln Arg Leu Leu Tyr Ile Pro Gly Ala Thr Val His His Ala Ala 
            20                  25                  30          


Gly Ser Tyr Arg Gly Glu 
        35              


<210>  58
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  58

Met Thr Val Thr Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val 
1               5                   10                  15      


Asp Ala Gly Lys Ala Asp His Tyr Cys Met Val Ile Asn Asp Asp Ala 
            20                  25                  30          


Gln Arg Leu Leu Ser Gln Arg Val Ala Asn Asp Glu Ala Ala Leu Leu 
        35                  40                  45              


Glu Leu Ile Ala Ala Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr 
    50                  55                  60                  


Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly Arg Thr Val 
                85                  90                  95      


His His Ala Ala Gly Ser Tyr Arg Gly Glu 
            100                 105     


<210>  59
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Met Thr Val Thr Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val 
1               5                   10                  15      


Asp Ala Gly Lys Ala Asp His Tyr Cys Met Val Ile Asn Asp Asp Ala 
            20                  25                  30          


Gln Arg Leu Leu Ser Gln Arg Val Ala Asn Asp Glu Ala Ala Leu Leu 
        35                  40                  45              


Glu Leu Ile Ala Ala Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr 
    50                  55                  60                  


Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly Ala Thr Val 
                85                  90                  95      


His His Ala Ala Gly Ser Tyr Arg Gly Glu 
            100                 105     


<210>  60
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  60

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Val Asp 
1               5                   10                  15      


Ala Gly Lys Ala Asp His Tyr Ala Val Thr Thr Leu Ala Asp Gly Gly 
            20                  25                  30          


Glu Val Thr Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu 
        35                  40                  45              


Ile Ala Leu Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly 
    50                  55                  60                  


Arg Thr Val His His Ala Ala Gly Ser Tyr Arg Gly Glu 
65                  70                  75          


<210>  61
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  61

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Val Asp 
1               5                   10                  15      


Ala Gly Lys Ala Asp His Tyr Ala Val Thr Thr Leu Ala Asp Gly Gly 
            20                  25                  30          


Glu Val Thr Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu 
        35                  40                  45              


Ile Ala Leu Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly 
    50                  55                  60                  


Ala Thr Val His His Ala Ala Gly Ser Tyr Arg Gly Glu 
65                  70                  75          


<210>  62
<211>  968
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vaccine polypeptide

<400>  62

Met Thr Val Thr Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val 
1               5                   10                  15      


Asp Ala Gly Lys Ala Asp His Tyr Cys Met Val Ile Asn Asp Asp Ala 
            20                  25                  30          


Gln Arg Leu Leu Ser Gln Arg Val Ala Asn Asp Glu Ala Ala Leu Leu 
        35                  40                  45              


Glu Leu Ile Ala Ala Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr 
    50                  55                  60                  


Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly Ala Thr Val 
                85                  90                  95      


His His Ala Ala Gly Ser Tyr Arg Gly Glu Ala Pro Val Lys Gln Thr 
            100                 105                 110         


Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
        115                 120                 125             


Gly Pro Met Gln Ile Phe Val Lys Leu Pro Leu Leu Thr Ile Gly Asp 
    130                 135                 140                 


Gln Phe Pro Ala Tyr Glu Leu Thr Ala Leu Ile Ala Gly Asp Leu Ser 
145                 150                 155                 160 


Lys Val Asp Ala Lys Gln Pro Gly Asp Tyr Phe Thr Thr Val Thr Ser 
                165                 170                 175     


Glu Asp His Ala Gly Lys Trp Arg Val Val Phe Phe Trp Pro Lys Asp 
            180                 185                 190         


Phe Thr Gly Pro Glu Ile Ala Thr Phe Gly Lys Leu Asn Asp Glu Phe 
        195                 200                 205             


Glu Asp Arg Asp Ala Gln Val Leu Gly Val Ser Ile Asp Ser Glu Phe 
    210                 215                 220                 


Val His Phe Asn Trp Arg Ala Gln His Glu Asp Leu Lys Asn Leu Pro 
225                 230                 235                 240 


Phe Pro Met Leu Ser Asp Ile Lys Arg Glu Leu Ser Leu Ala Thr Gly 
                245                 250                 255     


Val Leu Asn Ala Asp Gly Val Ala Asp Arg Ala Thr Phe Ile Val Asp 
            260                 265                 270         


Pro Asn Asn Glu Ile Gln Phe Val Ser Val Thr Ala Gly Ser Val Gly 
        275                 280                 285             


Arg Asn Val Glu Glu Val Leu Arg Val Leu Asp Ala Leu Gln Ser Asp 
    290                 295                 300                 


Glu Leu Cys Ala Cys Asn Trp Arg Lys Gly Asp Pro Thr Leu Asn Ala 
305                 310                 315                 320 


Thr Glu Leu Leu Lys Ala Ser Ala Leu Gly Ser Ile Val Gly Gln Thr 
                325                 330                 335     


Tyr Arg Glu Val Glu Val Val Leu Val Asp Gly Gly Ser Thr Asp Arg 
            340                 345                 350         


Thr Leu Asp Ile Ala Asn Ser Phe Arg Pro Glu Leu Gly Ser Arg Leu 
        355                 360                 365             


Val Val His Ser Gly Pro Asp Asp Gly Pro Tyr Asp Ala Met Asn Arg 
    370                 375                 380                 


Gly Val Gly Val Ala Thr Gly Glu Trp Val Leu Phe Leu Gly Ala Asp 
385                 390                 395                 400 


Asp Thr Leu Tyr Glu Pro Thr Thr Leu Ala Gln Val Ala Ala Phe Leu 
                405                 410                 415     


Gly Asp His Ala Ala Ser His Leu Val Tyr Gly Asp Val Val Met Arg 
            420                 425                 430         


Ser Thr Lys Ser Arg His Ala Gly Pro Phe Asp Leu Asp Arg Leu Leu 
        435                 440                 445             


Phe Glu Thr Asn Leu Cys His Gln Ser Ile Phe Tyr Arg Arg Glu Leu 
    450                 455                 460                 


Phe Asp Gly Ile Gly Pro Tyr Asn Leu Arg Tyr Arg Val Trp Ala Asp 
465                 470                 475                 480 


Trp Asp Phe Asn Ile Arg Cys Phe Ser Asn Pro Ala Leu Ile Thr Arg 
                485                 490                 495     


Tyr Met Asp Val Val Ile Ser Glu Tyr Asn Asp Met Thr Gly Phe Ser 
            500                 505                 510         


Met Arg Gln Gly Thr Asp Lys Glu Phe Arg Lys Arg Leu Pro Met Tyr 
        515                 520                 525             


Phe Trp Val Ala Gly Trp Glu Thr Cys Arg Arg Met Leu Ala Phe Leu 
    530                 535                 540                 


Lys Asp Lys Glu Asn Arg Arg Leu Ala Leu Arg Thr Arg Leu Ile Arg 
545                 550                 555                 560 


Val Lys Ala Val Ser Lys Glu Arg Ser Ala Glu Pro Arg Ile Arg Arg 
                565                 570                 575     


His Arg His Ala Glu Ile Ile Leu Ser Met Pro Gly Phe Gly Val Ile 
            580                 585                 590         


Leu Gly Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp Met Ala Ala Phe 
        595                 600                 605             


Ala Ser Ala Asp Arg Leu Ala Gly Val Ala Gly Leu Ala Pro Val Pro 
    610                 615                 620                 


Arg Asp Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg Pro Arg Arg Tyr 
625                 630                 635                 640 


Asp Arg Arg Leu Leu Arg Ala Cys Tyr Leu Ser Ala Leu Val Ser Ile 
                645                 650                 655     


Arg Thr Asp Pro Ser Ser Arg Thr Tyr Tyr Asp Arg Lys Arg Thr Glu 
            660                 665                 670         


Gly Lys Arg His Thr Gln Ala Val Leu Ala Leu Ala Arg Arg Arg Leu 
        675                 680                 685             


Asn Val Leu Trp Ala Met Leu Arg Asp His Ala Val Tyr His Pro Ala 
    690                 695                 700                 


Thr Thr Thr Ala Ala Ala Arg Leu Lys Leu Arg Arg Gly Glu Arg Pro 
705                 710                 715                 720 


Met Ser Leu Gly Gln Val Phe Asp Pro Arg Ala Asn Ala Leu His Ser 
                725                 730                 735     


Phe Pro Leu Thr Gly Arg Met Pro Trp Ala Pro Phe Ile Val Ser Ser 
            740                 745                 750         


Trp Leu Arg Asn Pro His Pro Ala Gln Tyr Phe Thr Ala Arg Cys Leu 
        755                 760                 765             


Arg Ile Leu Pro Gly Leu Trp Ile Gly Ala Gln Gly Gly Ser Ala Ala 
    770                 775                 780                 


Lys Leu Leu Met Ser Gly Ala Pro Ile Glu Tyr Val Leu Lys Asp Ser 
785                 790                 795                 800 


Ala Val Trp Met Phe Lys Phe Asp Ile Gly Gly Thr Pro Arg Asp Ile 
                805                 810                 815     


Pro Val Ala Gly Ile Trp Asn Gly Ser Leu Trp Thr Pro Ala Trp Gly 
            820                 825                 830         


Gly Ile His Ala Ile Ala Ser Asn Ala Tyr Gln Phe Arg Asn Val Ile 
        835                 840                 845             


Pro Ala Arg Trp Ser Val Ser Ser Ala Val Leu Pro Asn Tyr Arg Leu 
    850                 855                 860                 


Val Ala Ala Leu Pro Met Ala Tyr His Asn Gln Arg Met Arg Phe Arg 
865                 870                 875                 880 


Thr Asp Leu Ser Tyr Gly Val Tyr Gly Phe Ala Glu Ile Asn Pro Ile 
                885                 890                 895     


Ala Leu Val Glu Lys Pro Ala Leu Ser Trp Lys Ser Arg Leu Arg Arg 
            900                 905                 910         


Lys Asn Ser Ser Ile Ala Leu Ala Asn Met Glu Asp Gly Gly Ser Val 
        915                 920                 925             


Gly Arg Ser Asn Asp Ile Pro Gly Arg Arg Ala Arg Phe Ile Gly Glu 
    930                 935                 940                 


Lys Ala Glu Asp Pro Pro Ala Pro Ser Pro Arg Pro Ala Leu Arg Ile 
945                 950                 955                 960 


Pro Asn Pro Leu Leu Gly Leu Asp 
                965             


<210>  63
<211>  963
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vaccine polypeptide

<400>  63

Met Thr Val Thr Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val 
1               5                   10                  15      


Asp Ala Gly Lys Ala Asp His Tyr Cys Met Val Ile Asn Asp Asp Ala 
            20                  25                  30          


Gln Arg Leu Leu Ser Gln Arg Val Ala Asn Asp Glu Ala Ala Leu Leu 
        35                  40                  45              


Glu Leu Ile Ala Ala Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr 
    50                  55                  60                  


Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly Ala Thr Val 
                85                  90                  95      


His His Ala Ala Gly Ser Tyr Arg Gly Glu Ala Pro Val Lys Gln Thr 
            100                 105                 110         


Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
        115                 120                 125             


Gly Pro Met Gln Ile Phe Val Lys Leu Pro Leu Leu Thr Ile Gly Asp 
    130                 135                 140                 


Gln Phe Pro Ala Tyr Glu Leu Thr Ala Leu Ile Ala Gly Asp Leu Ser 
145                 150                 155                 160 


Lys Val Asp Ala Lys Gln Pro Gly Asp Tyr Phe Thr Thr Val Thr Ser 
                165                 170                 175     


Glu Asp His Ala Gly Lys Trp Arg Val Val Phe Phe Trp Pro Lys Asp 
            180                 185                 190         


Phe Thr Gly Pro Glu Ile Ala Thr Phe Gly Lys Leu Asn Asp Glu Phe 
        195                 200                 205             


Glu Asp Arg Asp Ala Gln Val Leu Gly Val Ser Ile Asp Ser Glu Phe 
    210                 215                 220                 


Val His Phe Asn Trp Arg Ala Gln His Glu Asp Leu Lys Asn Leu Pro 
225                 230                 235                 240 


Phe Pro Met Leu Ser Asp Ile Lys Arg Glu Leu Ser Leu Ala Thr Gly 
                245                 250                 255     


Val Leu Asn Ala Asp Gly Val Ala Asp Arg Ala Thr Phe Ile Val Asp 
            260                 265                 270         


Pro Asn Asn Glu Ile Gln Phe Val Ser Val Thr Ala Gly Ser Val Gly 
        275                 280                 285             


Arg Asn Val Glu Glu Val Leu Arg Val Leu Asp Ala Leu Gln Ser Asp 
    290                 295                 300                 


Glu Leu Cys Ala Cys Asn Trp Arg Lys Gly Asp Pro Thr Leu Asn Ala 
305                 310                 315                 320 


Thr Glu Leu Leu Lys Ala Ser Ala Leu Gly Ser Ile Val Gly Gln Thr 
                325                 330                 335     


Tyr Arg Glu Val Glu Val Val Leu Val Asp Gly Gly Ser Thr Asp Arg 
            340                 345                 350         


Thr Leu Asp Ile Ala Asn Ser Phe Arg Pro Glu Leu Gly Ser Arg Leu 
        355                 360                 365             


Val Val His Ser Gly Pro Asp Asp Gly Pro Tyr Asp Ala Met Asn Arg 
    370                 375                 380                 


Gly Val Gly Val Ala Thr Gly Glu Trp Val Leu Phe Leu Gly Ala Asp 
385                 390                 395                 400 


Asp Thr Leu Tyr Glu Pro Thr Thr Leu Ala Gln Val Ala Ala Phe Leu 
                405                 410                 415     


Gly Asp His Ala Ala Ser His Leu Val Tyr Gly Asp Val Val Met Arg 
            420                 425                 430         


Ser Thr Lys Ser Arg His Ala Gly Pro Phe Asp Leu Asp Arg Leu Leu 
        435                 440                 445             


Phe Glu Thr Asn Leu Cys His Gln Ser Ile Phe Tyr Arg Arg Glu Leu 
    450                 455                 460                 


Phe Asp Gly Ile Gly Pro Tyr Asn Leu Arg Tyr Arg Val Trp Ala Asp 
465                 470                 475                 480 


Trp Asp Phe Asn Ile Arg Cys Phe Ser Asn Pro Ala Leu Ile Thr Arg 
                485                 490                 495     


Tyr Met Asp Val Val Ile Ser Glu Tyr Asn Asp Met Thr Gly Phe Ser 
            500                 505                 510         


Met Arg Gln Gly Thr Asp Lys Glu Phe Arg Lys Arg Leu Pro Met Tyr 
        515                 520                 525             


Phe Trp Val Ala Gly Trp Glu Thr Cys Arg Arg Met Leu Ala Phe Leu 
    530                 535                 540                 


Lys Asp Lys Glu Asn Arg Arg Leu Ala Leu Arg Thr Arg Leu Ile Arg 
545                 550                 555                 560 


Val Lys Ala Val Ser Lys Glu Arg Ser Ala Glu Pro Arg Ile Arg Arg 
                565                 570                 575     


His Arg His Ala Glu Ile Ile Leu Ser Met Pro Gly Phe Gly Val Ile 
            580                 585                 590         


Leu Gly Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp Met Ala Ala Phe 
        595                 600                 605             


Ala Ser Ala Asp Arg Leu Ala Gly Val Ala Gly Leu Ala Pro Val Pro 
    610                 615                 620                 


Arg Asp Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg Pro Arg Arg Tyr 
625                 630                 635                 640 


Asp Arg Arg Leu Leu Arg Ala Cys Val Ser Ile Arg Thr Asp Pro Ser 
                645                 650                 655     


Ser Arg Thr Tyr Tyr Asp Arg Lys Arg Thr Glu Gly Lys Arg His Thr 
            660                 665                 670         


Gln Ala Val Leu Ala Leu Ala Arg Arg Arg Leu Asn Val Leu Trp Ala 
        675                 680                 685             


Met Leu Arg Asp His Ala Val Tyr His Pro Ala Thr Thr Thr Ala Ala 
    690                 695                 700                 


Ala Arg Leu Lys Leu Arg Arg Gly Glu Arg Pro Met Ser Leu Gly Gln 
705                 710                 715                 720 


Val Phe Asp Pro Arg Ala Asn Ala Leu His Ser Phe Pro Leu Thr Gly 
                725                 730                 735     


Arg Met Pro Trp Ala Pro Phe Ile Val Ser Ser Trp Leu Arg Asn Pro 
            740                 745                 750         


His Pro Ala Gln Tyr Phe Thr Ala Arg Cys Leu Arg Ile Leu Pro Gly 
        755                 760                 765             


Leu Trp Ile Gly Ala Gln Gly Gly Ser Ala Ala Lys Leu Leu Met Ser 
    770                 775                 780                 


Gly Ala Pro Ile Glu Tyr Val Leu Lys Asp Ser Ala Val Trp Met Phe 
785                 790                 795                 800 


Lys Phe Asp Ile Gly Gly Thr Pro Arg Asp Ile Pro Val Ala Gly Ile 
                805                 810                 815     


Trp Asn Gly Ser Leu Trp Thr Pro Ala Trp Gly Gly Ile His Ala Ile 
            820                 825                 830         


Ala Ser Asn Ala Tyr Gln Phe Arg Asn Val Ile Pro Ala Arg Trp Ser 
        835                 840                 845             


Val Ser Ser Ala Val Leu Pro Asn Tyr Arg Leu Val Ala Ala Leu Pro 
    850                 855                 860                 


Met Ala Tyr His Asn Gln Arg Met Arg Phe Arg Thr Asp Leu Ser Tyr 
865                 870                 875                 880 


Gly Val Tyr Gly Phe Ala Glu Ile Asn Pro Ile Ala Leu Val Glu Lys 
                885                 890                 895     


Pro Ala Leu Ser Trp Lys Ser Arg Leu Arg Arg Lys Asn Ser Ser Ile 
            900                 905                 910         


Ala Leu Ala Asn Met Glu Asp Gly Gly Ser Val Gly Arg Ser Asn Asp 
        915                 920                 925             


Ile Pro Gly Arg Arg Ala Arg Phe Ile Gly Glu Lys Ala Glu Asp Pro 
    930                 935                 940                 


Pro Ala Pro Ser Pro Arg Pro Ala Leu Arg Ile Pro Asn Pro Leu Leu 
945                 950                 955                 960 


Gly Leu Asp 
            


<210>  64
<211>  968
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vaccine polypeptide

<400>  64

Met Thr Val Thr Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val 
1               5                   10                  15      


Asp Ala Gly Lys Ala Asp His Tyr Cys Met Val Ile Asn Asp Asp Ala 
            20                  25                  30          


Gln Arg Leu Leu Ser Gln Arg Val Ala Asn Asp Glu Ala Ala Leu Leu 
        35                  40                  45              


Glu Leu Ile Ala Ala Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr 
    50                  55                  60                  


Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly Arg Thr Val 
                85                  90                  95      


His His Ala Ala Gly Ser Tyr Arg Gly Glu Ala Pro Val Lys Gln Thr 
            100                 105                 110         


Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
        115                 120                 125             


Gly Pro Met Gln Ile Phe Val Lys Leu Pro Leu Leu Thr Ile Gly Asp 
    130                 135                 140                 


Gln Phe Pro Ala Tyr Glu Leu Thr Ala Leu Ile Ala Gly Asp Leu Ser 
145                 150                 155                 160 


Lys Val Asp Ala Lys Gln Pro Gly Asp Tyr Phe Thr Thr Val Thr Ser 
                165                 170                 175     


Glu Asp His Ala Gly Lys Trp Arg Val Val Phe Phe Trp Pro Lys Asp 
            180                 185                 190         


Phe Thr Gly Pro Glu Ile Ala Thr Phe Gly Lys Leu Asn Asp Glu Phe 
        195                 200                 205             


Glu Asp Arg Asp Ala Gln Val Leu Gly Val Ser Ile Asp Ser Glu Phe 
    210                 215                 220                 


Val His Phe Asn Trp Arg Ala Gln His Glu Asp Leu Lys Asn Leu Pro 
225                 230                 235                 240 


Phe Pro Met Leu Ser Asp Ile Lys Arg Glu Leu Ser Leu Ala Thr Gly 
                245                 250                 255     


Val Leu Asn Ala Asp Gly Val Ala Asp Arg Ala Thr Phe Ile Val Asp 
            260                 265                 270         


Pro Asn Asn Glu Ile Gln Phe Val Ser Val Thr Ala Gly Ser Val Gly 
        275                 280                 285             


Arg Asn Val Glu Glu Val Leu Arg Val Leu Asp Ala Leu Gln Ser Asp 
    290                 295                 300                 


Glu Leu Cys Ala Cys Asn Trp Arg Lys Gly Asp Pro Thr Leu Asn Ala 
305                 310                 315                 320 


Thr Glu Leu Leu Lys Ala Ser Ala Leu Gly Ser Ile Val Gly Gln Thr 
                325                 330                 335     


Tyr Arg Glu Val Glu Val Val Leu Val Asp Gly Gly Ser Thr Asp Arg 
            340                 345                 350         


Thr Leu Asp Ile Ala Asn Ser Phe Arg Pro Glu Leu Gly Ser Arg Leu 
        355                 360                 365             


Val Val His Ser Gly Pro Asp Asp Gly Pro Tyr Asp Ala Met Asn Arg 
    370                 375                 380                 


Gly Val Gly Val Ala Thr Gly Glu Trp Val Leu Phe Leu Gly Ala Asp 
385                 390                 395                 400 


Asp Thr Leu Tyr Glu Pro Thr Thr Leu Ala Gln Val Ala Ala Phe Leu 
                405                 410                 415     


Gly Asp His Ala Ala Ser His Leu Val Tyr Gly Asp Val Val Met Arg 
            420                 425                 430         


Ser Thr Lys Ser Arg His Ala Gly Pro Phe Asp Leu Asp Arg Leu Leu 
        435                 440                 445             


Phe Glu Thr Asn Leu Cys His Gln Ser Ile Phe Tyr Arg Arg Glu Leu 
    450                 455                 460                 


Phe Asp Gly Ile Gly Pro Tyr Asn Leu Arg Tyr Arg Val Trp Ala Asp 
465                 470                 475                 480 


Trp Asp Phe Asn Ile Arg Cys Phe Ser Asn Pro Ala Leu Ile Thr Arg 
                485                 490                 495     


Tyr Met Asp Val Val Ile Ser Glu Tyr Asn Asp Met Thr Gly Phe Ser 
            500                 505                 510         


Met Arg Gln Gly Thr Asp Lys Glu Phe Arg Lys Arg Leu Pro Met Tyr 
        515                 520                 525             


Phe Trp Val Ala Gly Trp Glu Thr Cys Arg Arg Met Leu Ala Phe Leu 
    530                 535                 540                 


Lys Asp Lys Glu Asn Arg Arg Leu Ala Leu Arg Thr Arg Leu Ile Arg 
545                 550                 555                 560 


Val Lys Ala Val Ser Lys Glu Arg Ser Ala Glu Pro Arg Ile Arg Arg 
                565                 570                 575     


His Arg His Ala Glu Ile Ile Leu Ser Met Pro Gly Phe Gly Val Ile 
            580                 585                 590         


Leu Gly Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp Met Ala Ala Phe 
        595                 600                 605             


Ala Ser Ala Asp Arg Leu Ala Gly Val Ala Gly Leu Ala Pro Val Pro 
    610                 615                 620                 


Arg Asp Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg Pro Arg Arg Tyr 
625                 630                 635                 640 


Asp Arg Arg Leu Leu Arg Ala Cys Tyr Leu Ser Ala Leu Val Ser Ile 
                645                 650                 655     


Arg Thr Asp Pro Ser Ser Arg Thr Tyr Tyr Asp Arg Lys Arg Thr Glu 
            660                 665                 670         


Gly Lys Arg His Thr Gln Ala Val Leu Ala Leu Ala Arg Arg Arg Leu 
        675                 680                 685             


Asn Val Leu Trp Ala Met Leu Arg Asp His Ala Val Tyr His Pro Ala 
    690                 695                 700                 


Thr Thr Thr Ala Ala Ala Arg Leu Lys Leu Arg Arg Gly Glu Arg Pro 
705                 710                 715                 720 


Met Ser Leu Gly Gln Val Phe Asp Pro Arg Ala Asn Ala Leu His Ser 
                725                 730                 735     


Phe Pro Leu Thr Gly Arg Met Pro Trp Ala Pro Phe Ile Val Ser Ser 
            740                 745                 750         


Trp Leu Arg Asn Pro His Pro Ala Gln Tyr Phe Thr Ala Arg Cys Leu 
        755                 760                 765             


Arg Ile Leu Pro Gly Leu Trp Ile Gly Ala Gln Gly Gly Ser Ala Ala 
    770                 775                 780                 


Lys Leu Leu Met Ser Gly Ala Pro Ile Glu Tyr Val Leu Lys Asp Ser 
785                 790                 795                 800 


Ala Val Trp Met Phe Lys Phe Asp Ile Gly Gly Thr Pro Arg Asp Ile 
                805                 810                 815     


Pro Val Ala Gly Ile Trp Asn Gly Ser Leu Trp Thr Pro Ala Trp Gly 
            820                 825                 830         


Gly Ile His Ala Ile Ala Ser Asn Ala Tyr Gln Phe Arg Asn Val Ile 
        835                 840                 845             


Pro Ala Arg Trp Ser Val Ser Ser Ala Val Leu Pro Asn Tyr Arg Leu 
    850                 855                 860                 


Val Ala Ala Leu Pro Met Ala Tyr His Asn Gln Arg Met Arg Phe Arg 
865                 870                 875                 880 


Thr Asp Leu Ser Tyr Gly Val Tyr Gly Phe Ala Glu Ile Asn Pro Ile 
                885                 890                 895     


Ala Leu Val Glu Lys Pro Ala Leu Ser Trp Lys Ser Arg Leu Arg Arg 
            900                 905                 910         


Lys Asn Ser Ser Ile Ala Leu Ala Asn Met Glu Asp Gly Gly Ser Val 
        915                 920                 925             


Gly Arg Ser Asn Asp Ile Pro Gly Arg Arg Ala Arg Phe Ile Gly Glu 
    930                 935                 940                 


Lys Ala Glu Asp Pro Pro Ala Pro Ser Pro Arg Pro Ala Leu Arg Ile 
945                 950                 955                 960 


Pro Asn Pro Leu Leu Gly Leu Asp 
                965             


<210>  65
<211>  963
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vaccine polypeptide

<400>  65

Met Thr Val Thr Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val 
1               5                   10                  15      


Asp Ala Gly Lys Ala Asp His Tyr Cys Met Val Ile Asn Asp Asp Ala 
            20                  25                  30          


Gln Arg Leu Leu Ser Gln Arg Val Ala Asn Asp Glu Ala Ala Leu Leu 
        35                  40                  45              


Glu Leu Ile Ala Ala Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr 
    50                  55                  60                  


Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly Arg Thr Val 
                85                  90                  95      


His His Ala Ala Gly Ser Tyr Arg Gly Glu Ala Pro Val Lys Gln Thr 
            100                 105                 110         


Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
        115                 120                 125             


Gly Pro Met Gln Ile Phe Val Lys Leu Pro Leu Leu Thr Ile Gly Asp 
    130                 135                 140                 


Gln Phe Pro Ala Tyr Glu Leu Thr Ala Leu Ile Ala Gly Asp Leu Ser 
145                 150                 155                 160 


Lys Val Asp Ala Lys Gln Pro Gly Asp Tyr Phe Thr Thr Val Thr Ser 
                165                 170                 175     


Glu Asp His Ala Gly Lys Trp Arg Val Val Phe Phe Trp Pro Lys Asp 
            180                 185                 190         


Phe Thr Gly Pro Glu Ile Ala Thr Phe Gly Lys Leu Asn Asp Glu Phe 
        195                 200                 205             


Glu Asp Arg Asp Ala Gln Val Leu Gly Val Ser Ile Asp Ser Glu Phe 
    210                 215                 220                 


Val His Phe Asn Trp Arg Ala Gln His Glu Asp Leu Lys Asn Leu Pro 
225                 230                 235                 240 


Phe Pro Met Leu Ser Asp Ile Lys Arg Glu Leu Ser Leu Ala Thr Gly 
                245                 250                 255     


Val Leu Asn Ala Asp Gly Val Ala Asp Arg Ala Thr Phe Ile Val Asp 
            260                 265                 270         


Pro Asn Asn Glu Ile Gln Phe Val Ser Val Thr Ala Gly Ser Val Gly 
        275                 280                 285             


Arg Asn Val Glu Glu Val Leu Arg Val Leu Asp Ala Leu Gln Ser Asp 
    290                 295                 300                 


Glu Leu Cys Ala Cys Asn Trp Arg Lys Gly Asp Pro Thr Leu Asn Ala 
305                 310                 315                 320 


Thr Glu Leu Leu Lys Ala Ser Ala Leu Gly Ser Ile Val Gly Gln Thr 
                325                 330                 335     


Tyr Arg Glu Val Glu Val Val Leu Val Asp Gly Gly Ser Thr Asp Arg 
            340                 345                 350         


Thr Leu Asp Ile Ala Asn Ser Phe Arg Pro Glu Leu Gly Ser Arg Leu 
        355                 360                 365             


Val Val His Ser Gly Pro Asp Asp Gly Pro Tyr Asp Ala Met Asn Arg 
    370                 375                 380                 


Gly Val Gly Val Ala Thr Gly Glu Trp Val Leu Phe Leu Gly Ala Asp 
385                 390                 395                 400 


Asp Thr Leu Tyr Glu Pro Thr Thr Leu Ala Gln Val Ala Ala Phe Leu 
                405                 410                 415     


Gly Asp His Ala Ala Ser His Leu Val Tyr Gly Asp Val Val Met Arg 
            420                 425                 430         


Ser Thr Lys Ser Arg His Ala Gly Pro Phe Asp Leu Asp Arg Leu Leu 
        435                 440                 445             


Phe Glu Thr Asn Leu Cys His Gln Ser Ile Phe Tyr Arg Arg Glu Leu 
    450                 455                 460                 


Phe Asp Gly Ile Gly Pro Tyr Asn Leu Arg Tyr Arg Val Trp Ala Asp 
465                 470                 475                 480 


Trp Asp Phe Asn Ile Arg Cys Phe Ser Asn Pro Ala Leu Ile Thr Arg 
                485                 490                 495     


Tyr Met Asp Val Val Ile Ser Glu Tyr Asn Asp Met Thr Gly Phe Ser 
            500                 505                 510         


Met Arg Gln Gly Thr Asp Lys Glu Phe Arg Lys Arg Leu Pro Met Tyr 
        515                 520                 525             


Phe Trp Val Ala Gly Trp Glu Thr Cys Arg Arg Met Leu Ala Phe Leu 
    530                 535                 540                 


Lys Asp Lys Glu Asn Arg Arg Leu Ala Leu Arg Thr Arg Leu Ile Arg 
545                 550                 555                 560 


Val Lys Ala Val Ser Lys Glu Arg Ser Ala Glu Pro Arg Ile Arg Arg 
                565                 570                 575     


His Arg His Ala Glu Ile Ile Leu Ser Met Pro Gly Phe Gly Val Ile 
            580                 585                 590         


Leu Gly Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp Met Ala Ala Phe 
        595                 600                 605             


Ala Ser Ala Asp Arg Leu Ala Gly Val Ala Gly Leu Ala Pro Val Pro 
    610                 615                 620                 


Arg Asp Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg Pro Arg Arg Tyr 
625                 630                 635                 640 


Asp Arg Arg Leu Leu Arg Ala Cys Val Ser Ile Arg Thr Asp Pro Ser 
                645                 650                 655     


Ser Arg Thr Tyr Tyr Asp Arg Lys Arg Thr Glu Gly Lys Arg His Thr 
            660                 665                 670         


Gln Ala Val Leu Ala Leu Ala Arg Arg Arg Leu Asn Val Leu Trp Ala 
        675                 680                 685             


Met Leu Arg Asp His Ala Val Tyr His Pro Ala Thr Thr Thr Ala Ala 
    690                 695                 700                 


Ala Arg Leu Lys Leu Arg Arg Gly Glu Arg Pro Met Ser Leu Gly Gln 
705                 710                 715                 720 


Val Phe Asp Pro Arg Ala Asn Ala Leu His Ser Phe Pro Leu Thr Gly 
                725                 730                 735     


Arg Met Pro Trp Ala Pro Phe Ile Val Ser Ser Trp Leu Arg Asn Pro 
            740                 745                 750         


His Pro Ala Gln Tyr Phe Thr Ala Arg Cys Leu Arg Ile Leu Pro Gly 
        755                 760                 765             


Leu Trp Ile Gly Ala Gln Gly Gly Ser Ala Ala Lys Leu Leu Met Ser 
    770                 775                 780                 


Gly Ala Pro Ile Glu Tyr Val Leu Lys Asp Ser Ala Val Trp Met Phe 
785                 790                 795                 800 


Lys Phe Asp Ile Gly Gly Thr Pro Arg Asp Ile Pro Val Ala Gly Ile 
                805                 810                 815     


Trp Asn Gly Ser Leu Trp Thr Pro Ala Trp Gly Gly Ile His Ala Ile 
            820                 825                 830         


Ala Ser Asn Ala Tyr Gln Phe Arg Asn Val Ile Pro Ala Arg Trp Ser 
        835                 840                 845             


Val Ser Ser Ala Val Leu Pro Asn Tyr Arg Leu Val Ala Ala Leu Pro 
    850                 855                 860                 


Met Ala Tyr His Asn Gln Arg Met Arg Phe Arg Thr Asp Leu Ser Tyr 
865                 870                 875                 880 


Gly Val Tyr Gly Phe Ala Glu Ile Asn Pro Ile Ala Leu Val Glu Lys 
                885                 890                 895     


Pro Ala Leu Ser Trp Lys Ser Arg Leu Arg Arg Lys Asn Ser Ser Ile 
            900                 905                 910         


Ala Leu Ala Asn Met Glu Asp Gly Gly Ser Val Gly Arg Ser Asn Asp 
        915                 920                 925             


Ile Pro Gly Arg Arg Ala Arg Phe Ile Gly Glu Lys Ala Glu Asp Pro 
    930                 935                 940                 


Pro Ala Pro Ser Pro Arg Pro Ala Leu Arg Ile Pro Asn Pro Leu Leu 
945                 950                 955                 960 


Gly Leu Asp 
            


<210>  66
<211>  939
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vaccine polypeptide

<400>  66

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Val Asp 
1               5                   10                  15      


Ala Gly Lys Ala Asp His Tyr Ala Val Thr Thr Leu Ala Asp Gly Gly 
            20                  25                  30          


Glu Val Thr Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu 
        35                  40                  45              


Ile Ala Leu Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly 
    50                  55                  60                  


Ala Thr Val His His Ala Ala Gly Ser Tyr Arg Gly Glu Ala Pro Val 
65                  70                  75                  80  


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                85                  90                  95      


Ser Asn Pro Gly Pro Met Gln Ile Phe Val Lys Leu Pro Leu Leu Thr 
            100                 105                 110         


Ile Gly Asp Gln Phe Pro Ala Tyr Glu Leu Thr Ala Leu Ile Ala Gly 
        115                 120                 125             


Asp Leu Ser Lys Val Asp Ala Lys Gln Pro Gly Asp Tyr Phe Thr Thr 
    130                 135                 140                 


Val Thr Ser Glu Asp His Ala Gly Lys Trp Arg Val Val Phe Phe Trp 
145                 150                 155                 160 


Pro Lys Asp Phe Thr Gly Pro Glu Ile Ala Thr Phe Gly Lys Leu Asn 
                165                 170                 175     


Asp Glu Phe Glu Asp Arg Asp Ala Gln Val Leu Gly Val Ser Ile Asp 
            180                 185                 190         


Ser Glu Phe Val His Phe Asn Trp Arg Ala Gln His Glu Asp Leu Lys 
        195                 200                 205             


Asn Leu Pro Phe Pro Met Leu Ser Asp Ile Lys Arg Glu Leu Ser Leu 
    210                 215                 220                 


Ala Thr Gly Val Leu Asn Ala Asp Gly Val Ala Asp Arg Ala Thr Phe 
225                 230                 235                 240 


Ile Val Asp Pro Asn Asn Glu Ile Gln Phe Val Ser Val Thr Ala Gly 
                245                 250                 255     


Ser Val Gly Arg Asn Val Glu Glu Val Leu Arg Val Leu Asp Ala Leu 
            260                 265                 270         


Gln Ser Asp Glu Leu Cys Ala Cys Asn Trp Arg Lys Gly Asp Pro Thr 
        275                 280                 285             


Leu Asn Ala Thr Glu Leu Leu Lys Ala Ser Ala Leu Gly Ser Ile Val 
    290                 295                 300                 


Gly Gln Thr Tyr Arg Glu Val Glu Val Val Leu Val Asp Gly Gly Ser 
305                 310                 315                 320 


Thr Asp Arg Thr Leu Asp Ile Ala Asn Ser Phe Arg Pro Glu Leu Gly 
                325                 330                 335     


Ser Arg Leu Val Val His Ser Gly Pro Asp Asp Gly Pro Tyr Asp Ala 
            340                 345                 350         


Met Asn Arg Gly Val Gly Val Ala Thr Gly Glu Trp Val Leu Phe Leu 
        355                 360                 365             


Gly Ala Asp Asp Thr Leu Tyr Glu Pro Thr Thr Leu Ala Gln Val Ala 
    370                 375                 380                 


Ala Phe Leu Gly Asp His Ala Ala Ser His Leu Val Tyr Gly Asp Val 
385                 390                 395                 400 


Val Met Arg Ser Thr Lys Ser Arg His Ala Gly Pro Phe Asp Leu Asp 
                405                 410                 415     


Arg Leu Leu Phe Glu Thr Asn Leu Cys His Gln Ser Ile Phe Tyr Arg 
            420                 425                 430         


Arg Glu Leu Phe Asp Gly Ile Gly Pro Tyr Asn Leu Arg Tyr Arg Val 
        435                 440                 445             


Trp Ala Asp Trp Asp Phe Asn Ile Arg Cys Phe Ser Asn Pro Ala Leu 
    450                 455                 460                 


Ile Thr Arg Tyr Met Asp Val Val Ile Ser Glu Tyr Asn Asp Met Thr 
465                 470                 475                 480 


Gly Phe Ser Met Arg Gln Gly Thr Asp Lys Glu Phe Arg Lys Arg Leu 
                485                 490                 495     


Pro Met Tyr Phe Trp Val Ala Gly Trp Glu Thr Cys Arg Arg Met Leu 
            500                 505                 510         


Ala Phe Leu Lys Asp Lys Glu Asn Arg Arg Leu Ala Leu Arg Thr Arg 
        515                 520                 525             


Leu Ile Arg Val Lys Ala Val Ser Lys Glu Arg Ser Ala Glu Pro Arg 
    530                 535                 540                 


Ile Arg Arg His Arg His Ala Glu Ile Ile Leu Ser Met Pro Gly Phe 
545                 550                 555                 560 


Gly Val Ile Leu Gly Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp Met 
                565                 570                 575     


Ala Ala Phe Ala Ser Ala Asp Arg Leu Ala Gly Val Ala Gly Leu Ala 
            580                 585                 590         


Pro Val Pro Arg Asp Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg Pro 
        595                 600                 605             


Arg Arg Tyr Asp Arg Arg Leu Leu Arg Ala Cys Tyr Leu Ser Ala Leu 
    610                 615                 620                 


Val Ser Ile Arg Thr Asp Pro Ser Ser Arg Thr Tyr Tyr Asp Arg Lys 
625                 630                 635                 640 


Arg Thr Glu Gly Lys Arg His Thr Gln Ala Val Leu Ala Leu Ala Arg 
                645                 650                 655     


Arg Arg Leu Asn Val Leu Trp Ala Met Leu Arg Asp His Ala Val Tyr 
            660                 665                 670         


His Pro Ala Thr Thr Thr Ala Ala Ala Arg Leu Lys Leu Arg Arg Gly 
        675                 680                 685             


Glu Arg Pro Met Ser Leu Gly Gln Val Phe Asp Pro Arg Ala Asn Ala 
    690                 695                 700                 


Leu His Ser Phe Pro Leu Thr Gly Arg Met Pro Trp Ala Pro Phe Ile 
705                 710                 715                 720 


Val Ser Ser Trp Leu Arg Asn Pro His Pro Ala Gln Tyr Phe Thr Ala 
                725                 730                 735     


Arg Cys Leu Arg Ile Leu Pro Gly Leu Trp Ile Gly Ala Gln Gly Gly 
            740                 745                 750         


Ser Ala Ala Lys Leu Leu Met Ser Gly Ala Pro Ile Glu Tyr Val Leu 
        755                 760                 765             


Lys Asp Ser Ala Val Trp Met Phe Lys Phe Asp Ile Gly Gly Thr Pro 
    770                 775                 780                 


Arg Asp Ile Pro Val Ala Gly Ile Trp Asn Gly Ser Leu Trp Thr Pro 
785                 790                 795                 800 


Ala Trp Gly Gly Ile His Ala Ile Ala Ser Asn Ala Tyr Gln Phe Arg 
                805                 810                 815     


Asn Val Ile Pro Ala Arg Trp Ser Val Ser Ser Ala Val Leu Pro Asn 
            820                 825                 830         


Tyr Arg Leu Val Ala Ala Leu Pro Met Ala Tyr His Asn Gln Arg Met 
        835                 840                 845             


Arg Phe Arg Thr Asp Leu Ser Tyr Gly Val Tyr Gly Phe Ala Glu Ile 
    850                 855                 860                 


Asn Pro Ile Ala Leu Val Glu Lys Pro Ala Leu Ser Trp Lys Ser Arg 
865                 870                 875                 880 


Leu Arg Arg Lys Asn Ser Ser Ile Ala Leu Ala Asn Met Glu Asp Gly 
                885                 890                 895     


Gly Ser Val Gly Arg Ser Asn Asp Ile Pro Gly Arg Arg Ala Arg Phe 
            900                 905                 910         


Ile Gly Glu Lys Ala Glu Asp Pro Pro Ala Pro Ser Pro Arg Pro Ala 
        915                 920                 925             


Leu Arg Ile Pro Asn Pro Leu Leu Gly Leu Asp 
    930                 935                 


<210>  67
<211>  934
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vaccine polypeptide

<400>  67

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Val Asp 
1               5                   10                  15      


Ala Gly Lys Ala Asp His Tyr Ala Val Thr Thr Leu Ala Asp Gly Gly 
            20                  25                  30          


Glu Val Thr Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu 
        35                  40                  45              


Ile Ala Leu Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly 
    50                  55                  60                  


Ala Thr Val His His Ala Ala Gly Ser Tyr Arg Gly Glu Ala Pro Val 
65                  70                  75                  80  


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                85                  90                  95      


Ser Asn Pro Gly Pro Met Gln Ile Phe Val Lys Leu Pro Leu Leu Thr 
            100                 105                 110         


Ile Gly Asp Gln Phe Pro Ala Tyr Glu Leu Thr Ala Leu Ile Ala Gly 
        115                 120                 125             


Asp Leu Ser Lys Val Asp Ala Lys Gln Pro Gly Asp Tyr Phe Thr Thr 
    130                 135                 140                 


Val Thr Ser Glu Asp His Ala Gly Lys Trp Arg Val Val Phe Phe Trp 
145                 150                 155                 160 


Pro Lys Asp Phe Thr Gly Pro Glu Ile Ala Thr Phe Gly Lys Leu Asn 
                165                 170                 175     


Asp Glu Phe Glu Asp Arg Asp Ala Gln Val Leu Gly Val Ser Ile Asp 
            180                 185                 190         


Ser Glu Phe Val His Phe Asn Trp Arg Ala Gln His Glu Asp Leu Lys 
        195                 200                 205             


Asn Leu Pro Phe Pro Met Leu Ser Asp Ile Lys Arg Glu Leu Ser Leu 
    210                 215                 220                 


Ala Thr Gly Val Leu Asn Ala Asp Gly Val Ala Asp Arg Ala Thr Phe 
225                 230                 235                 240 


Ile Val Asp Pro Asn Asn Glu Ile Gln Phe Val Ser Val Thr Ala Gly 
                245                 250                 255     


Ser Val Gly Arg Asn Val Glu Glu Val Leu Arg Val Leu Asp Ala Leu 
            260                 265                 270         


Gln Ser Asp Glu Leu Cys Ala Cys Asn Trp Arg Lys Gly Asp Pro Thr 
        275                 280                 285             


Leu Asn Ala Thr Glu Leu Leu Lys Ala Ser Ala Leu Gly Ser Ile Val 
    290                 295                 300                 


Gly Gln Thr Tyr Arg Glu Val Glu Val Val Leu Val Asp Gly Gly Ser 
305                 310                 315                 320 


Thr Asp Arg Thr Leu Asp Ile Ala Asn Ser Phe Arg Pro Glu Leu Gly 
                325                 330                 335     


Ser Arg Leu Val Val His Ser Gly Pro Asp Asp Gly Pro Tyr Asp Ala 
            340                 345                 350         


Met Asn Arg Gly Val Gly Val Ala Thr Gly Glu Trp Val Leu Phe Leu 
        355                 360                 365             


Gly Ala Asp Asp Thr Leu Tyr Glu Pro Thr Thr Leu Ala Gln Val Ala 
    370                 375                 380                 


Ala Phe Leu Gly Asp His Ala Ala Ser His Leu Val Tyr Gly Asp Val 
385                 390                 395                 400 


Val Met Arg Ser Thr Lys Ser Arg His Ala Gly Pro Phe Asp Leu Asp 
                405                 410                 415     


Arg Leu Leu Phe Glu Thr Asn Leu Cys His Gln Ser Ile Phe Tyr Arg 
            420                 425                 430         


Arg Glu Leu Phe Asp Gly Ile Gly Pro Tyr Asn Leu Arg Tyr Arg Val 
        435                 440                 445             


Trp Ala Asp Trp Asp Phe Asn Ile Arg Cys Phe Ser Asn Pro Ala Leu 
    450                 455                 460                 


Ile Thr Arg Tyr Met Asp Val Val Ile Ser Glu Tyr Asn Asp Met Thr 
465                 470                 475                 480 


Gly Phe Ser Met Arg Gln Gly Thr Asp Lys Glu Phe Arg Lys Arg Leu 
                485                 490                 495     


Pro Met Tyr Phe Trp Val Ala Gly Trp Glu Thr Cys Arg Arg Met Leu 
            500                 505                 510         


Ala Phe Leu Lys Asp Lys Glu Asn Arg Arg Leu Ala Leu Arg Thr Arg 
        515                 520                 525             


Leu Ile Arg Val Lys Ala Val Ser Lys Glu Arg Ser Ala Glu Pro Arg 
    530                 535                 540                 


Ile Arg Arg His Arg His Ala Glu Ile Ile Leu Ser Met Pro Gly Phe 
545                 550                 555                 560 


Gly Val Ile Leu Gly Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp Met 
                565                 570                 575     


Ala Ala Phe Ala Ser Ala Asp Arg Leu Ala Gly Val Ala Gly Leu Ala 
            580                 585                 590         


Pro Val Pro Arg Asp Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg Pro 
        595                 600                 605             


Arg Arg Tyr Asp Arg Arg Leu Leu Arg Ala Cys Val Ser Ile Arg Thr 
    610                 615                 620                 


Asp Pro Ser Ser Arg Thr Tyr Tyr Asp Arg Lys Arg Thr Glu Gly Lys 
625                 630                 635                 640 


Arg His Thr Gln Ala Val Leu Ala Leu Ala Arg Arg Arg Leu Asn Val 
                645                 650                 655     


Leu Trp Ala Met Leu Arg Asp His Ala Val Tyr His Pro Ala Thr Thr 
            660                 665                 670         


Thr Ala Ala Ala Arg Leu Lys Leu Arg Arg Gly Glu Arg Pro Met Ser 
        675                 680                 685             


Leu Gly Gln Val Phe Asp Pro Arg Ala Asn Ala Leu His Ser Phe Pro 
    690                 695                 700                 


Leu Thr Gly Arg Met Pro Trp Ala Pro Phe Ile Val Ser Ser Trp Leu 
705                 710                 715                 720 


Arg Asn Pro His Pro Ala Gln Tyr Phe Thr Ala Arg Cys Leu Arg Ile 
                725                 730                 735     


Leu Pro Gly Leu Trp Ile Gly Ala Gln Gly Gly Ser Ala Ala Lys Leu 
            740                 745                 750         


Leu Met Ser Gly Ala Pro Ile Glu Tyr Val Leu Lys Asp Ser Ala Val 
        755                 760                 765             


Trp Met Phe Lys Phe Asp Ile Gly Gly Thr Pro Arg Asp Ile Pro Val 
    770                 775                 780                 


Ala Gly Ile Trp Asn Gly Ser Leu Trp Thr Pro Ala Trp Gly Gly Ile 
785                 790                 795                 800 


His Ala Ile Ala Ser Asn Ala Tyr Gln Phe Arg Asn Val Ile Pro Ala 
                805                 810                 815     


Arg Trp Ser Val Ser Ser Ala Val Leu Pro Asn Tyr Arg Leu Val Ala 
            820                 825                 830         


Ala Leu Pro Met Ala Tyr His Asn Gln Arg Met Arg Phe Arg Thr Asp 
        835                 840                 845             


Leu Ser Tyr Gly Val Tyr Gly Phe Ala Glu Ile Asn Pro Ile Ala Leu 
    850                 855                 860                 


Val Glu Lys Pro Ala Leu Ser Trp Lys Ser Arg Leu Arg Arg Lys Asn 
865                 870                 875                 880 


Ser Ser Ile Ala Leu Ala Asn Met Glu Asp Gly Gly Ser Val Gly Arg 
                885                 890                 895     


Ser Asn Asp Ile Pro Gly Arg Arg Ala Arg Phe Ile Gly Glu Lys Ala 
            900                 905                 910         


Glu Asp Pro Pro Ala Pro Ser Pro Arg Pro Ala Leu Arg Ile Pro Asn 
        915                 920                 925             


Pro Leu Leu Gly Leu Asp 
    930                 


<210>  68
<211>  939
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vaccine polypeptide

<400>  68

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Val Asp 
1               5                   10                  15      


Ala Gly Lys Ala Asp His Tyr Ala Val Thr Thr Leu Ala Asp Gly Gly 
            20                  25                  30          


Glu Val Thr Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu 
        35                  40                  45              


Ile Ala Leu Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly 
    50                  55                  60                  


Arg Thr Val His His Ala Ala Gly Ser Tyr Arg Gly Glu Ala Pro Val 
65                  70                  75                  80  


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                85                  90                  95      


Ser Asn Pro Gly Pro Met Gln Ile Phe Val Lys Leu Pro Leu Leu Thr 
            100                 105                 110         


Ile Gly Asp Gln Phe Pro Ala Tyr Glu Leu Thr Ala Leu Ile Ala Gly 
        115                 120                 125             


Asp Leu Ser Lys Val Asp Ala Lys Gln Pro Gly Asp Tyr Phe Thr Thr 
    130                 135                 140                 


Val Thr Ser Glu Asp His Ala Gly Lys Trp Arg Val Val Phe Phe Trp 
145                 150                 155                 160 


Pro Lys Asp Phe Thr Gly Pro Glu Ile Ala Thr Phe Gly Lys Leu Asn 
                165                 170                 175     


Asp Glu Phe Glu Asp Arg Asp Ala Gln Val Leu Gly Val Ser Ile Asp 
            180                 185                 190         


Ser Glu Phe Val His Phe Asn Trp Arg Ala Gln His Glu Asp Leu Lys 
        195                 200                 205             


Asn Leu Pro Phe Pro Met Leu Ser Asp Ile Lys Arg Glu Leu Ser Leu 
    210                 215                 220                 


Ala Thr Gly Val Leu Asn Ala Asp Gly Val Ala Asp Arg Ala Thr Phe 
225                 230                 235                 240 


Ile Val Asp Pro Asn Asn Glu Ile Gln Phe Val Ser Val Thr Ala Gly 
                245                 250                 255     


Ser Val Gly Arg Asn Val Glu Glu Val Leu Arg Val Leu Asp Ala Leu 
            260                 265                 270         


Gln Ser Asp Glu Leu Cys Ala Cys Asn Trp Arg Lys Gly Asp Pro Thr 
        275                 280                 285             


Leu Asn Ala Thr Glu Leu Leu Lys Ala Ser Ala Leu Gly Ser Ile Val 
    290                 295                 300                 


Gly Gln Thr Tyr Arg Glu Val Glu Val Val Leu Val Asp Gly Gly Ser 
305                 310                 315                 320 


Thr Asp Arg Thr Leu Asp Ile Ala Asn Ser Phe Arg Pro Glu Leu Gly 
                325                 330                 335     


Ser Arg Leu Val Val His Ser Gly Pro Asp Asp Gly Pro Tyr Asp Ala 
            340                 345                 350         


Met Asn Arg Gly Val Gly Val Ala Thr Gly Glu Trp Val Leu Phe Leu 
        355                 360                 365             


Gly Ala Asp Asp Thr Leu Tyr Glu Pro Thr Thr Leu Ala Gln Val Ala 
    370                 375                 380                 


Ala Phe Leu Gly Asp His Ala Ala Ser His Leu Val Tyr Gly Asp Val 
385                 390                 395                 400 


Val Met Arg Ser Thr Lys Ser Arg His Ala Gly Pro Phe Asp Leu Asp 
                405                 410                 415     


Arg Leu Leu Phe Glu Thr Asn Leu Cys His Gln Ser Ile Phe Tyr Arg 
            420                 425                 430         


Arg Glu Leu Phe Asp Gly Ile Gly Pro Tyr Asn Leu Arg Tyr Arg Val 
        435                 440                 445             


Trp Ala Asp Trp Asp Phe Asn Ile Arg Cys Phe Ser Asn Pro Ala Leu 
    450                 455                 460                 


Ile Thr Arg Tyr Met Asp Val Val Ile Ser Glu Tyr Asn Asp Met Thr 
465                 470                 475                 480 


Gly Phe Ser Met Arg Gln Gly Thr Asp Lys Glu Phe Arg Lys Arg Leu 
                485                 490                 495     


Pro Met Tyr Phe Trp Val Ala Gly Trp Glu Thr Cys Arg Arg Met Leu 
            500                 505                 510         


Ala Phe Leu Lys Asp Lys Glu Asn Arg Arg Leu Ala Leu Arg Thr Arg 
        515                 520                 525             


Leu Ile Arg Val Lys Ala Val Ser Lys Glu Arg Ser Ala Glu Pro Arg 
    530                 535                 540                 


Ile Arg Arg His Arg His Ala Glu Ile Ile Leu Ser Met Pro Gly Phe 
545                 550                 555                 560 


Gly Val Ile Leu Gly Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp Met 
                565                 570                 575     


Ala Ala Phe Ala Ser Ala Asp Arg Leu Ala Gly Val Ala Gly Leu Ala 
            580                 585                 590         


Pro Val Pro Arg Asp Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg Pro 
        595                 600                 605             


Arg Arg Tyr Asp Arg Arg Leu Leu Arg Ala Cys Tyr Leu Ser Ala Leu 
    610                 615                 620                 


Val Ser Ile Arg Thr Asp Pro Ser Ser Arg Thr Tyr Tyr Asp Arg Lys 
625                 630                 635                 640 


Arg Thr Glu Gly Lys Arg His Thr Gln Ala Val Leu Ala Leu Ala Arg 
                645                 650                 655     


Arg Arg Leu Asn Val Leu Trp Ala Met Leu Arg Asp His Ala Val Tyr 
            660                 665                 670         


His Pro Ala Thr Thr Thr Ala Ala Ala Arg Leu Lys Leu Arg Arg Gly 
        675                 680                 685             


Glu Arg Pro Met Ser Leu Gly Gln Val Phe Asp Pro Arg Ala Asn Ala 
    690                 695                 700                 


Leu His Ser Phe Pro Leu Thr Gly Arg Met Pro Trp Ala Pro Phe Ile 
705                 710                 715                 720 


Val Ser Ser Trp Leu Arg Asn Pro His Pro Ala Gln Tyr Phe Thr Ala 
                725                 730                 735     


Arg Cys Leu Arg Ile Leu Pro Gly Leu Trp Ile Gly Ala Gln Gly Gly 
            740                 745                 750         


Ser Ala Ala Lys Leu Leu Met Ser Gly Ala Pro Ile Glu Tyr Val Leu 
        755                 760                 765             


Lys Asp Ser Ala Val Trp Met Phe Lys Phe Asp Ile Gly Gly Thr Pro 
    770                 775                 780                 


Arg Asp Ile Pro Val Ala Gly Ile Trp Asn Gly Ser Leu Trp Thr Pro 
785                 790                 795                 800 


Ala Trp Gly Gly Ile His Ala Ile Ala Ser Asn Ala Tyr Gln Phe Arg 
                805                 810                 815     


Asn Val Ile Pro Ala Arg Trp Ser Val Ser Ser Ala Val Leu Pro Asn 
            820                 825                 830         


Tyr Arg Leu Val Ala Ala Leu Pro Met Ala Tyr His Asn Gln Arg Met 
        835                 840                 845             


Arg Phe Arg Thr Asp Leu Ser Tyr Gly Val Tyr Gly Phe Ala Glu Ile 
    850                 855                 860                 


Asn Pro Ile Ala Leu Val Glu Lys Pro Ala Leu Ser Trp Lys Ser Arg 
865                 870                 875                 880 


Leu Arg Arg Lys Asn Ser Ser Ile Ala Leu Ala Asn Met Glu Asp Gly 
                885                 890                 895     


Gly Ser Val Gly Arg Ser Asn Asp Ile Pro Gly Arg Arg Ala Arg Phe 
            900                 905                 910         


Ile Gly Glu Lys Ala Glu Asp Pro Pro Ala Pro Ser Pro Arg Pro Ala 
        915                 920                 925             


Leu Arg Ile Pro Asn Pro Leu Leu Gly Leu Asp 
    930                 935                 


<210>  69
<211>  934
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vaccine polypeptide

<400>  69

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Val Asp 
1               5                   10                  15      


Ala Gly Lys Ala Asp His Tyr Ala Val Thr Thr Leu Ala Asp Gly Gly 
            20                  25                  30          


Glu Val Thr Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu 
        35                  40                  45              


Ile Ala Leu Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly 
    50                  55                  60                  


Arg Thr Val His His Ala Ala Gly Ser Tyr Arg Gly Glu Ala Pro Val 
65                  70                  75                  80  


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                85                  90                  95      


Ser Asn Pro Gly Pro Met Gln Ile Phe Val Lys Leu Pro Leu Leu Thr 
            100                 105                 110         


Ile Gly Asp Gln Phe Pro Ala Tyr Glu Leu Thr Ala Leu Ile Ala Gly 
        115                 120                 125             


Asp Leu Ser Lys Val Asp Ala Lys Gln Pro Gly Asp Tyr Phe Thr Thr 
    130                 135                 140                 


Val Thr Ser Glu Asp His Ala Gly Lys Trp Arg Val Val Phe Phe Trp 
145                 150                 155                 160 


Pro Lys Asp Phe Thr Gly Pro Glu Ile Ala Thr Phe Gly Lys Leu Asn 
                165                 170                 175     


Asp Glu Phe Glu Asp Arg Asp Ala Gln Val Leu Gly Val Ser Ile Asp 
            180                 185                 190         


Ser Glu Phe Val His Phe Asn Trp Arg Ala Gln His Glu Asp Leu Lys 
        195                 200                 205             


Asn Leu Pro Phe Pro Met Leu Ser Asp Ile Lys Arg Glu Leu Ser Leu 
    210                 215                 220                 


Ala Thr Gly Val Leu Asn Ala Asp Gly Val Ala Asp Arg Ala Thr Phe 
225                 230                 235                 240 


Ile Val Asp Pro Asn Asn Glu Ile Gln Phe Val Ser Val Thr Ala Gly 
                245                 250                 255     


Ser Val Gly Arg Asn Val Glu Glu Val Leu Arg Val Leu Asp Ala Leu 
            260                 265                 270         


Gln Ser Asp Glu Leu Cys Ala Cys Asn Trp Arg Lys Gly Asp Pro Thr 
        275                 280                 285             


Leu Asn Ala Thr Glu Leu Leu Lys Ala Ser Ala Leu Gly Ser Ile Val 
    290                 295                 300                 


Gly Gln Thr Tyr Arg Glu Val Glu Val Val Leu Val Asp Gly Gly Ser 
305                 310                 315                 320 


Thr Asp Arg Thr Leu Asp Ile Ala Asn Ser Phe Arg Pro Glu Leu Gly 
                325                 330                 335     


Ser Arg Leu Val Val His Ser Gly Pro Asp Asp Gly Pro Tyr Asp Ala 
            340                 345                 350         


Met Asn Arg Gly Val Gly Val Ala Thr Gly Glu Trp Val Leu Phe Leu 
        355                 360                 365             


Gly Ala Asp Asp Thr Leu Tyr Glu Pro Thr Thr Leu Ala Gln Val Ala 
    370                 375                 380                 


Ala Phe Leu Gly Asp His Ala Ala Ser His Leu Val Tyr Gly Asp Val 
385                 390                 395                 400 


Val Met Arg Ser Thr Lys Ser Arg His Ala Gly Pro Phe Asp Leu Asp 
                405                 410                 415     


Arg Leu Leu Phe Glu Thr Asn Leu Cys His Gln Ser Ile Phe Tyr Arg 
            420                 425                 430         


Arg Glu Leu Phe Asp Gly Ile Gly Pro Tyr Asn Leu Arg Tyr Arg Val 
        435                 440                 445             


Trp Ala Asp Trp Asp Phe Asn Ile Arg Cys Phe Ser Asn Pro Ala Leu 
    450                 455                 460                 


Ile Thr Arg Tyr Met Asp Val Val Ile Ser Glu Tyr Asn Asp Met Thr 
465                 470                 475                 480 


Gly Phe Ser Met Arg Gln Gly Thr Asp Lys Glu Phe Arg Lys Arg Leu 
                485                 490                 495     


Pro Met Tyr Phe Trp Val Ala Gly Trp Glu Thr Cys Arg Arg Met Leu 
            500                 505                 510         


Ala Phe Leu Lys Asp Lys Glu Asn Arg Arg Leu Ala Leu Arg Thr Arg 
        515                 520                 525             


Leu Ile Arg Val Lys Ala Val Ser Lys Glu Arg Ser Ala Glu Pro Arg 
    530                 535                 540                 


Ile Arg Arg His Arg His Ala Glu Ile Ile Leu Ser Met Pro Gly Phe 
545                 550                 555                 560 


Gly Val Ile Leu Gly Ala Glu Phe Leu Ala Ala Thr Gly Gly Asp Met 
                565                 570                 575     


Ala Ala Phe Ala Ser Ala Asp Arg Leu Ala Gly Val Ala Gly Leu Ala 
            580                 585                 590         


Pro Val Pro Arg Asp Ser Gly Arg Ile Ser Gly Asn Leu Lys Arg Pro 
        595                 600                 605             


Arg Arg Tyr Asp Arg Arg Leu Leu Arg Ala Cys Val Ser Ile Arg Thr 
    610                 615                 620                 


Asp Pro Ser Ser Arg Thr Tyr Tyr Asp Arg Lys Arg Thr Glu Gly Lys 
625                 630                 635                 640 


Arg His Thr Gln Ala Val Leu Ala Leu Ala Arg Arg Arg Leu Asn Val 
                645                 650                 655     


Leu Trp Ala Met Leu Arg Asp His Ala Val Tyr His Pro Ala Thr Thr 
            660                 665                 670         


Thr Ala Ala Ala Arg Leu Lys Leu Arg Arg Gly Glu Arg Pro Met Ser 
        675                 680                 685             


Leu Gly Gln Val Phe Asp Pro Arg Ala Asn Ala Leu His Ser Phe Pro 
    690                 695                 700                 


Leu Thr Gly Arg Met Pro Trp Ala Pro Phe Ile Val Ser Ser Trp Leu 
705                 710                 715                 720 


Arg Asn Pro His Pro Ala Gln Tyr Phe Thr Ala Arg Cys Leu Arg Ile 
                725                 730                 735     


Leu Pro Gly Leu Trp Ile Gly Ala Gln Gly Gly Ser Ala Ala Lys Leu 
            740                 745                 750         


Leu Met Ser Gly Ala Pro Ile Glu Tyr Val Leu Lys Asp Ser Ala Val 
        755                 760                 765             


Trp Met Phe Lys Phe Asp Ile Gly Gly Thr Pro Arg Asp Ile Pro Val 
    770                 775                 780                 


Ala Gly Ile Trp Asn Gly Ser Leu Trp Thr Pro Ala Trp Gly Gly Ile 
785                 790                 795                 800 


His Ala Ile Ala Ser Asn Ala Tyr Gln Phe Arg Asn Val Ile Pro Ala 
                805                 810                 815     


Arg Trp Ser Val Ser Ser Ala Val Leu Pro Asn Tyr Arg Leu Val Ala 
            820                 825                 830         


Ala Leu Pro Met Ala Tyr His Asn Gln Arg Met Arg Phe Arg Thr Asp 
        835                 840                 845             


Leu Ser Tyr Gly Val Tyr Gly Phe Ala Glu Ile Asn Pro Ile Ala Leu 
    850                 855                 860                 


Val Glu Lys Pro Ala Leu Ser Trp Lys Ser Arg Leu Arg Arg Lys Asn 
865                 870                 875                 880 


Ser Ser Ile Ala Leu Ala Asn Met Glu Asp Gly Gly Ser Val Gly Arg 
                885                 890                 895     


Ser Asn Asp Ile Pro Gly Arg Arg Ala Arg Phe Ile Gly Glu Lys Ala 
            900                 905                 910         


Glu Asp Pro Pro Ala Pro Ser Pro Arg Pro Ala Leu Arg Ile Pro Asn 
        915                 920                 925             


Pro Leu Leu Gly Leu Asp 
    930                 


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a 2A peptide fragment


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  70

Gly Asp Val Glu Xaa Asn Pro Gly Pro 
1               5                   


<210>  71
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a 2A peptide

<400>  71

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  72
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment

<400>  72

Met Thr Val Thr 
1               


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  73

Val Asp Ala Gly Lys Ala Asp His Tyr Ala 
1               5                   10  


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  74

Met Gln Ile Phe Val Lys Leu 
1               5           


<210>  75
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide tag

<400>  75

Pro Ala Leu Arg Ile Pro Asn Pro Leu Leu Gly Leu Asp 
1               5                   10              


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpa T cell epitope

<400>  76

Gly Phe Ala Glu Ile Asn Pro Ile Ala 
1               5                   


<210>  77
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  77

Ser Gly Ser Gly 
1               


<210>  78
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  78

Gly Gly Gly Ser 
1               


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  79

Glu Ala Ala Ala Lys 
1               5   


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  80

His Glu Tyr Gly Ala Glu Ala Leu Glu Arg Ala Gly 
1               5                   10          


<210>  81
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  81

Tyr Leu Ser Ala Leu Val Ser Ile Arg Thr Asp Pro Ser Ser Arg 
1               5                   10                  15  


<210>  82
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  PHOSPHORYLATION

<400>  82

Tyr Leu Ser Ala Leu Val Ser Ile Arg Thr Asp Pro Ser Ser Arg 
1               5                   10                  15  


<210>  83
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vaccine polypeptide

<400>  83

Met Thr Val Thr Glu Val Val Val Ala Gln Pro Val Trp Ala Gly Val 
1               5                   10                  15      


Asp Ala Gly Lys Ala Asp His Tyr Cys Met Val Ile Asn Asp Asp Ala 
            20                  25                  30          


Gln Arg Leu Leu Ser Gln Arg Val Ala Asn Asp Glu Ala Ala Leu Leu 
        35                  40                  45              


Glu Leu Ile Ala Ala Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr 
    50                  55                  60                  


Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly Ala Thr Val 
                85                  90                  95      


His His Ala Ala Gly Ser Tyr Arg Gly Glu 
            100                 105     


<210>  84
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vaccine polypeptide

<400>  84

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Val Asp 
1               5                   10                  15      


Ala Gly Lys Ala Asp His Tyr Ala Val Thr Thr Leu Ala Asp Gly Gly 
            20                  25                  30          


Glu Val Thr Trp Ala Ile Asp Leu Asn Ala Gly Gly Ala Ala Leu Leu 
        35                  40                  45              


Ile Ala Leu Leu Ile Ala Ala Gly Gln Arg Leu Leu Tyr Ile Pro Gly 
    50                  55                  60                  


Ala Thr Val His His Ala Ala Gly Ser Tyr Arg Gly Glu 
65                  70                  75          


<210>  85
<211>  15
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  85

Glu Leu Ile Ala Ala Val Thr Thr Leu Ala Asp Gly Gly Glu Val 
1               5                   10                  15  


<210>  86
<211>  15
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  86

Asp Arg Lys Arg Thr Glu Gly Lys Arg His Thr Gln Ala Val Leu 
1               5                   10                  15  


<210>  87
<211>  15
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  87

Asn Lys Ser Arg Ala Ala Leu Ile Leu Leu Thr Gly Tyr Gln Thr 
1               5                   10                  15  


<210>  88
<211>  15
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  88

Ala Lys Glu Val Met Ala Leu Asp Thr Glu Ile Gly Asp Thr Asp 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  89

Ala Leu Asp Thr Glu Ile Gly Asp Thr Asp Ala Met Ile Glu Glu 
1               5                   10                  15  


<210>  90
<211>  40
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  90

Gly Arg Ile Ser Gly Asn Leu Lys Arg Pro Arg Arg Tyr Asp Arg Arg 
1               5                   10                  15      


Leu Leu Arg Ala Cys Tyr Leu Ser Ala Leu Val Ser Ile Arg Thr Asp 
            20                  25                  30          


Pro Ser Ser Arg Thr Tyr Tyr Asp 
        35                  40  


<210>  91
<211>  18
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  91

Asn Lys Ser Arg Ala Ala Leu Ile Leu Leu Thr Gly Tyr Gln Thr Pro 
1               5                   10                  15      


Asp Ala 
        


<210>  92
<211>  18
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  92

Asn Leu Lys Arg Pro Arg Arg Tyr Asp Arg Arg Leu Leu Arg Ala Gly 
1               5                   10                  15      


Tyr Leu 
        


<210>  93
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  93

Met Val Ile Asn Asp Asp Ala Gln Arg Leu 
1               5                   10  


<210>  94
<211>  11
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  94

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Cys 
1               5                   10      


<210>  95
<211>  11
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  95

Cys Asn Leu Lys Arg Pro Arg Arg Tyr Asp Arg 
1               5                   10      


<210>  96
<211>  11
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  96

Cys Val Ser Ile Arg Thr Asp Pro Ser Ser Arg 
1               5                   10      


<210>  97
<211>  15
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  97

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Cys 
1               5                   10                  15  


<210>  98
<211>  16
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  98

Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr Trp Ala Ile Asp Cys 
1               5                   10                  15      


<210>  99
<211>  16
<212>  PRT
<213>  Mycobacterium avium paratuberculosis

<400>  99

Tyr Leu Ser Ala Leu Val Ser Ile Arg Thr Asp Pro Ser Ser Arg Cys 
1               5                   10                  15      


<210>  100
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  8branchedPolylysineOctamer

<400>  100

Met Val Ile Asn Asp Asp Ala Gln Arg Leu 
1               5                   10  


<210>  101
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  101

Met Val Ile Asn Asp Asp Ala Gln Arg Leu 
1               5                   10  


<210>  102
<211>  9
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  102

Met Val Ile Asn Asp Asp Leu Gln Arg 
1               5                   


<210>  103
<211>  8
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  103

Met Val Ile Asn Asn Asp Ala Glu 
1               5               


<210>  104
<211>  11
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  8branchedPolylysineOctamer

<400>  104

Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr 
1               5                   10      


<210>  105
<211>  11
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  105

Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr 
1               5                   10      


<210>  106
<211>  11
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  106

Val Ala Thr Met Ala Asp Gly Gly Glu Val Thr 
1               5                   10      


<210>  107
<211>  11
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  107

Val Thr Arg Leu Ala Asp Gly Gly Glu Val Thr 
1               5                   10      


<210>  108
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  8branchedPolylysineOctamer

<400>  108

Asn Leu Lys Arg Pro Arg Arg Tyr Asp Arg 
1               5                   10  


<210>  109
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  109

Asn Leu Lys Arg Pro Arg Arg Tyr Asp Arg 
1               5                   10  


<210>  110
<211>  7
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  110

Asn Leu Lys Arg Pro Arg Arg 
1               5           


<210>  111
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  ACETYLATION

<400>  111

Asn Leu Arg Arg Pro Arg Arg Tyr His Arg 
1               5                   10  


<210>  112
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  112

Asn Leu His Arg Pro Arg Arg Tyr His Arg 
1               5                   10  


<210>  113
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  113

Asn Met Arg Arg Pro Arg Arg Tyr Asn Arg 
1               5                   10  


<210>  114
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  114

Asn Leu Arg Arg Pro Lys Arg Tyr Asn Arg 
1               5                   10  


<210>  115
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  115

Asn Leu Gln Arg Pro Arg Arg Tyr Asn Arg 
1               5                   10  


<210>  116
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  8branchedPolylysineOctamer

<400>  116

Val Ser Ile Arg Thr Asp Pro Ser Ser Arg 
1               5                   10  


<210>  117
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  117

Val Ser Ile Arg Thr Asp Pro Ser Ser Arg 
1               5                   10  


<210>  118
<211>  7
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  biotinyl

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  118

Val Ser Ile Arg Thr Asp Pro 
1               5           


<210>  119
<211>  9
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  119

Ser Ile Arg Ser Asp Pro Ser Ser Arg 
1               5                   


<210>  120
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  120

Tyr Ser Ile Arg Ser Asp Pro Ala Ser Arg 
1               5                   10  


<210>  121
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  121

Val Ser Val Arg Tyr Asp Pro Ser Ser Arg 
1               5                   10  


<210>  122
<211>  10
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  122

Ile Ala Ile Arg Thr Asp Pro Ala Ser Arg 
1               5                   10  


<210>  123
<211>  11
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  123

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Cys 
1               5                   10      


<210>  124
<211>  12
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  124

Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr Cys 
1               5                   10          


<210>  125
<211>  11
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  125

Asn Leu Lys Arg Pro Arg Arg Tyr Asp Arg Cys 
1               5                   10      


<210>  126
<211>  11
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  126

Val Ser Ile Arg Thr Asp Pro Ser Ser Arg Cys 
1               5                   10      


<210>  127
<211>  15
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  127

Cys Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg 
1               5                   10                  15  


<210>  128
<211>  14
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AMIDATION

<400>  128

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg 
1               5                   10                  


<210>  129
<211>  14
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AMIDATION

<400>  129

Met Val Ile Asn Asp Asp Leu Gln Arg Ile Ile Leu Phe Leu 
1               5                   10                  


<210>  130
<211>  14
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AMIDATION

<400>  130

Met Ser Ile Asn Asp Asp Ala Gln Lys Leu Lys Asp Arg Leu 
1               5                   10                  


<210>  131
<211>  15
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Amide BSA conjugated

<400>  131

Cys Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg 
1               5                   10                  15  


<210>  132
<211>  14
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AMIDATION

<400>  132

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg 
1               5                   10                  


<210>  133
<211>  14
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AMIDATION

<400>  133

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg 
1               5                   10                  


<210>  134
<211>  21
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  BSA conjugated

<400>  134

Ala Ala Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr Trp Ala Ile 
1               5                   10                  15      


Asp Gly Lys Lys Cys 
            20      


<210>  135
<211>  20
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  AMIDATION

<400>  135

Lys Lys Gly Ala Ala Val Thr Thr Leu Ala Asp Gly Gly Glu Val Thr 
1               5                   10                  15      


Trp Ala Ile Asp 
            20  


<210>  136
<211>  20
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  AMIDATION

<400>  136

Lys Lys Gly Ala Ala Gly Thr Thr Leu Ala Asp Gly Gly Glu Val Thr 
1               5                   10                  15      


Trp Ala Ile Asp 
            20  


<210>  137
<211>  20
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  AMIDATION

<400>  137

Lys Lys Gly Ser Thr Val Ala Thr Met Ala Asp Gly Gly Glu Val Thr 
1               5                   10                  15      


Trp Ala Ile Asp 
            20  


<210>  138
<211>  20
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  AMIDATION

<400>  138

Lys Lys Gly Gln Ala Val Thr Arg Leu Ala Asp Gly Gly Glu Val Thr 
1               5                   10                  15      


Trp Ala Val Asp 
            20  


<210>  139
<211>  20
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  AMIDATION

<400>  139

Lys Lys Gly Phe Glu Val Thr Thr Leu Ala Asp Gly Thr Glu Val Ala 
1               5                   10                  15      


Thr Ser Pro Leu 
            20  


<210>  140
<211>  16
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Amide BSA conjugated

<400>  140

Cys Tyr Leu Ser Ala Leu Val Ser Ile Arg Thr Asp Pro Ser Ser Arg 
1               5                   10                  15      


<210>  141
<211>  15
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  141

Tyr Leu Ser Ala Leu Val Ser Ile Arg Thr Asp Pro Ser Ser Arg 
1               5                   10                  15  


<210>  142
<211>  15
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  142

Tyr Leu Ser Ala Leu Val Ser Ile Arg Thr Asp Pro Ser Ser Arg 
1               5                   10                  15  


<210>  143
<211>  15
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  143

Tyr Leu Ser Ala Leu Tyr Ser Ile Arg Ser Asp Pro Ala Ser Arg 
1               5                   10                  15  


<210>  144
<211>  15
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  144

Tyr Leu Ser Ala Leu Val Ser Val Arg Tyr Asp Pro Ser Ser Arg 
1               5                   10                  15  


<210>  145
<211>  15
<212>  PRT
<213>  Mycobacterium avium paratuberculosis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinyl

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  145

Tyr Leu Ser Ala Gln Ile Ala Ile Arg Thr Asp Pro Ala Ser Arg 
1               5                   10                  15  


<210>  146
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  146

Met Val Ile Asn Asp Asp Ala Gln Arg Leu Leu Ser Gln Arg Val Asp 
1               5                   10                  15      


Ala Gly Lys Ala Asp His Tyr Ala Val Thr Thr Leu Ala Asp Gly Gly 
            20                  25                  30          


Glu Val Thr Trp Ala Ile Asp Leu Asn Ala 
        35                  40          


