                         SEQUENCE LISTING

<110>  Cardiff Metropolitan University
 
<120>  Frailty Prognostic

<130>  0279P/WO

<150>  GB1811517.0
<151>  2018-07-13

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Glu Gly Phe Asp Lys 
                325                 330                 335     


Val Arg Glu Ala Glu Asp Ser Pro Gln His Met 
            340                 345         


<210>  2
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly 
                325                 330     


<210>  3
<211>  1463
<212>  DNA
<213>  Homo sapiens

<400>  3
ctgaaagatg ggggctggag agagggtgca ggccccacct agggcggagg ccacagcagg       60

gagaggggca gacagagcca ggaccctgga aggaagcagg atggcagccg gaacagcagt      120

tggagcctgg gtgctggtcc tcagtctgtg gggggcagta gtaggtgctc aaaacatcac      180

agcccggatt ggcgagccac tggtgctgaa gtgtaagggg gcccccaaga aaccacccca      240

gcggctggaa tggaaactga acacaggccg gacagaagct tggaaggtcc tgtctcccca      300

gggaggaggc ccctgggaca gtgtggctcg tgtccttccc aacggctccc tcttccttcc      360

ggctgtcggg atccaggatg aggggatttt ccggtgccag gcaatgaaca ggaatggaaa      420

ggagaccaag tccaactacc gagtccgtgt ctaccagatt cctgggaagc cagaaattgt      480

agattctgcc tctgaactca cggctggtgt tcccaataag gtggggacat gtgtgtcaga      540

gggaagctac cctgcaggga ctcttagctg gcacttggat gggaagcccc tggtgcctaa      600

tgagaaggga gtatctgtga aggaacagac caggagacac cctgagacag ggctcttcac      660

actgcagtcg gagctaatgg tgaccccagc ccggggagga gatccccgtc ccaccttctc      720

ctgtagcttc agcccaggcc ttccccgaca ccgggccttg cgcacagccc ccatccagcc      780

ccgtgtctgg gagcctgtgc ctctggagga ggtccaattg gtggtggagc cagaaggtgg      840

agcagtagct cctggtggaa ccgtaaccct gacctgtgaa gtccctgccc agccctctcc      900

tcaaatccac tggatgaagg atggtgtgcc cttgcccctt ccccccagcc ctgtgctgat      960

cctccctgag atagggcctc aggaccaggg aacctacagc tgtgtggcca cccattccag     1020

ccacgggccc caggaaagcc gtgctgtcag catcagcatc atcgaaccag gcgaggaggg     1080

gccaactgca ggtgaggggt ttgataaagt cagggaagca gaagatagcc cccaacacat     1140

gtgactgggg ggatggtcaa caagaaagga atggaaggcc ccagaaaacc aggaggaaga     1200

ggaggagcgt gcagaactga atcagtcgga ggaacctgag gcaggcgaga gtagtactgg     1260

agggccttga ggggcccaca gacagatccc atccatcagc tcccttttct ttttcccttg     1320

aactgttctg gcctcagacc aactctctcc tgtataatct ctctcctgta taaccccacc     1380

ttgccaagct ttcttctaca accagagccc cccacaatga tgattaaaca cctgacacat     1440

cttgcaaaaa aaaaaaaaaa aaa                                             1463


<210>  4
<211>  1508
<212>  DNA
<213>  Homo sapiens

<400>  4
ctgaaagatg ggggctggag agagggtgca ggccccacct agggcggagg ccacagcagg       60

gagaggggca gacagagcca ggaccctgga aggaagcagg atggcagccg gaacagcagt      120

tggagcctgg gtgctggtcc tcagtctgtg gggggcagta gtaggtgctc aaaacatcac      180

agcccggatt ggcgagccac tggtgctgaa gtgtaagggg gcccccaaga aaccacccca      240

gcggctggaa tggaaactga acacaggccg gacagaagct tggaaggtcc tgtctcccca      300

gggaggaggc ccctgggaca gtgtggctcg tgtccttccc aacggctccc tcttccttcc      360

ggctgtcggg atccaggatg aggggatttt ccggtgccag gcaatgaaca ggaatggaaa      420

ggagaccaag tccaactacc gagtccgtgt ctaccagatt cctgggaagc cagaaattgt      480

agattctgcc tctgaactca cggctggtgt tcccaataag gtggggacat gtgtgtcaga      540

gggaagctac cctgcaggga ctcttagctg gcacttggat gggaagcccc tggtgcctaa      600

tgagaaggga gtatctgtga aggaacagac caggagacac cctgagacag ggctcttcac      660

actgcagtcg gagctaatgg tgaccccagc ccggggagga gatccccgtc ccaccttctc      720

ctgtagcttc agcccaggcc ttccccgaca ccgggccttg cgcacagccc ccatccagcc      780

ccgtgtctgg gagcctgtgc ctctggagga ggtccaattg gtggtggagc cagaaggtgg      840

agcagtagct cctggtggaa ccgtaaccct gacctgtgaa gtccctgccc agccctctcc      900

tcaaatccac tggatgaagg atggtgtgcc cttgcccctt ccccccagcc ctgtgctgat      960

cctccctgag atagggcctc aggaccaggg aacctacagc tgtgtggcca cccattccag     1020

ccacgggccc caggaaagcc gtgctgtcag catcagcatc atcgaaccag gcgaggaggg     1080

gccaactgca ggctctgtgg gaggatcagg gctgggaact ctagccctgg ccctggggat     1140

cctgggaggc ctggggacag ccgccctgct cattggggtc atcttgtggc aaaggcggca     1200

acgccgagga gaggagagga aggccccaga aaaccaggag gaagaggagg agcgtgcaga     1260

actgaatcag tcggaggaac ctgaggcagg cgagagtagt actggagggc cttgaggggc     1320

ccacagacag atcccatcca tcagctccct tttctttttc ccttgaactg ttctggcctc     1380

agaccaactc tctcctgtat aatctctctc ctgtataacc ccaccttgcc aagctttctt     1440

ctacaaccag agccccccac aatgatgatt aaacacctga cacatcttgc aaaaaaaaaa     1500

aaaaaaaa                                                              1508


