                         SEQUENCE LISTING

<110>  Thyrolytics AB
 
<120>  Biosensor for Diagnosis of Thyroid Dysfunction

<130>  P4912PC00

<150>  EP 18183439.1
<151>  2018-07-13

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  249
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(1)
<223>  DIO1

<220>
<221>  PEPTIDE
<222>  (126)..(126)
<223>  X=Selenocystein

<400>  1

Met Gly Leu Pro Gln Pro Gly Leu Trp Leu Lys Arg Leu Trp Val Leu 
1               5                   10                  15      


Leu Glu Val Ala Val His Val Val Val Gly Lys Val Leu Leu Ile Leu 
            20                  25                  30          


Phe Pro Asp Arg Val Lys Arg Asn Ile Leu Ala Met Gly Glu Lys Thr 
        35                  40                  45              


Gly Met Thr Arg Asn Pro His Phe Ser His Asp Asn Trp Ile Pro Thr 
    50                  55                  60                  


Phe Phe Ser Thr Gln Tyr Phe Trp Phe Val Leu Lys Val Arg Trp Gln 
65                  70                  75                  80  


Arg Leu Glu Asp Thr Thr Glu Leu Gly Gly Leu Ala Pro Asn Cys Pro 
                85                  90                  95      


Val Val Arg Leu Ser Gly Gln Arg Cys Asn Ile Trp Glu Phe Met Gln 
            100                 105                 110         


Gly Asn Arg Pro Leu Val Leu Asn Phe Gly Ser Cys Thr Xaa Pro Ser 
        115                 120                 125             


Phe Met Phe Lys Phe Asp Gln Phe Lys Arg Leu Ile Glu Asp Phe Ser 
    130                 135                 140                 


Ser Ile Ala Asp Phe Leu Val Ile Tyr Ile Glu Glu Ala His Ala Ser 
145                 150                 155                 160 


Asp Gly Trp Ala Phe Lys Asn Asn Met Asp Ile Arg Asn His Gln Asn 
                165                 170                 175     


Leu Gln Asp Arg Leu Gln Ala Ala His Leu Leu Leu Ala Arg Ser Pro 
            180                 185                 190         


Gln Cys Pro Val Val Val Asp Thr Met Gln Asn Gln Ser Ser Gln Leu 
        195                 200                 205             


Tyr Ala Ala Leu Pro Glu Arg Leu Tyr Ile Ile Gln Glu Gly Arg Ile 
    210                 215                 220                 


Leu Tyr Lys Gly Lys Ser Gly Pro Trp Asn Tyr Asn Pro Glu Glu Val 
225                 230                 235                 240 


Arg Ala Val Leu Glu Lys Leu His Ser 
                245                 


<210>  2
<211>  273
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(1)
<223>  DIO2

<220>
<221>  PEPTIDE
<222>  (133)..(133)
<223>  X=selenocysteine

<220>
<221>  PEPTIDE
<222>  (266)..(266)
<223>  X=selenocysteine

<400>  2

Met Gly Ile Leu Ser Val Asp Leu Leu Ile Thr Leu Gln Ile Leu Pro 
1               5                   10                  15      


Val Phe Phe Ser Asn Cys Leu Phe Leu Ala Leu Tyr Asp Ser Val Ile 
            20                  25                  30          


Leu Leu Lys His Val Val Leu Leu Leu Ser Arg Ser Lys Ser Thr Arg 
        35                  40                  45              


Gly Glu Trp Arg Arg Met Leu Thr Ser Glu Gly Leu Arg Cys Val Trp 
    50                  55                  60                  


Lys Ser Phe Leu Leu Asp Ala Tyr Lys Gln Val Lys Leu Gly Glu Asp 
65                  70                  75                  80  


Ala Pro Asn Ser Ser Val Val His Val Ser Ser Thr Glu Gly Gly Asp 
                85                  90                  95      


Asn Ser Gly Asn Gly Thr Gln Glu Lys Ile Ala Glu Gly Ala Thr Cys 
            100                 105                 110         


His Leu Leu Asp Phe Ala Ser Pro Glu Arg Pro Leu Val Val Asn Phe 
        115                 120                 125             


Gly Ser Ala Thr Xaa Pro Pro Phe Thr Ser Gln Leu Pro Ala Phe Arg 
    130                 135                 140                 


Lys Leu Val Glu Glu Phe Ser Ser Val Ala Asp Phe Leu Leu Val Tyr 
145                 150                 155                 160 


Ile Asp Glu Ala His Pro Ser Asp Gly Trp Ala Ile Pro Gly Asp Ser 
                165                 170                 175     


Ser Leu Ser Phe Glu Val Lys Lys His Gln Asn Gln Glu Asp Arg Cys 
            180                 185                 190         


Ala Ala Ala Gln Gln Leu Leu Glu Arg Phe Ser Leu Pro Pro Gln Cys 
        195                 200                 205             


Arg Val Val Ala Asp Arg Met Asp Asn Asn Ala Asn Ile Ala Tyr Gly 
    210                 215                 220                 


Val Ala Phe Glu Arg Val Cys Ile Val Gln Arg Gln Lys Ile Ala Tyr 
225                 230                 235                 240 


Leu Gly Gly Lys Gly Pro Phe Ser Tyr Asn Leu Gln Glu Val Arg His 
                245                 250                 255     


Trp Leu Glu Lys Asn Phe Ser Lys Arg Xaa Lys Lys Thr Arg Leu Ala 
            260                 265                 270         


Gly 
    


<210>  3
<211>  304
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(1)
<223>  DIO3

<220>
<221>  PEPTIDE
<222>  (170)..(170)
<223>  X=selenocysteine

<400>  3

Met Pro Arg Gln Ala Thr Ser Arg Leu Val Val Gly Glu Gly Glu Gly 
1               5                   10                  15      


Ser Gln Gly Ala Ser Gly Pro Ala Ala Thr Met Leu Arg Ser Leu Leu 
            20                  25                  30          


Leu His Ser Leu Arg Leu Cys Ala Gln Thr Ala Ser Cys Leu Val Leu 
        35                  40                  45              


Phe Pro Arg Phe Leu Gly Thr Ala Phe Met Leu Trp Leu Leu Asp Phe 
    50                  55                  60                  


Leu Cys Ile Arg Lys His Phe Leu Gly Arg Arg Arg Arg Gly Gln Pro 
65                  70                  75                  80  


Glu Pro Glu Val Glu Leu Asn Ser Glu Gly Glu Glu Val Pro Pro Asp 
                85                  90                  95      


Asp Pro Pro Ile Cys Val Ser Asp Asp Asn Arg Leu Cys Thr Leu Ala 
            100                 105                 110         


Ser Leu Lys Ala Val Trp His Gly Gln Lys Leu Asp Phe Phe Lys Gln 
        115                 120                 125             


Ala His Glu Gly Gly Pro Ala Pro Asn Ser Glu Val Val Leu Pro Asp 
    130                 135                 140                 


Gly Phe Gln Ser Gln His Ile Leu Asp Tyr Ala Gln Gly Asn Arg Pro 
145                 150                 155                 160 


Leu Val Leu Asn Phe Gly Ser Cys Thr Xaa Pro Pro Phe Met Ala Arg 
                165                 170                 175     


Met Ser Ala Phe Gln Arg Leu Val Thr Lys Tyr Gln Arg Asp Val Asp 
            180                 185                 190         


Phe Leu Ile Ile Tyr Ile Glu Glu Ala His Pro Ser Asp Gly Trp Val 
        195                 200                 205             


Thr Thr Asp Ser Pro Tyr Ile Ile Pro Gln His Arg Ser Leu Glu Asp 
    210                 215                 220                 


Arg Val Ser Ala Ala Arg Val Leu Gln Gln Gly Ala Pro Gly Cys Ala 
225                 230                 235                 240 


Leu Val Leu Asp Thr Met Ala Asn Ser Ser Ser Ser Ala Tyr Gly Ala 
                245                 250                 255     


Tyr Phe Glu Arg Leu Tyr Val Ile Gln Ser Gly Thr Ile Met Tyr Gln 
            260                 265                 270         


Gly Gly Arg Gly Pro Asp Gly Tyr Gln Val Ser Glu Leu Arg Thr Trp 
        275                 280                 285             


Leu Glu Arg Tyr Asp Glu Gln Leu His Gly Ala Arg Pro Arg Arg Val 
    290                 295                 300                 


