                         SEQUENCE LISTING

<110>  Inserm
 
<120>  ANTIBODIES HAVING SPECIFICITY FOR THE ORF2I PROTEIN OF HEPATITIS 
       E VIRUS AND USES THEREOF FOR DIAGNOSTIC PURPOSES

<130>  BIO18236 COCQUEREL / MC

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  647
<212>  PRT
<213>  Hepatitis E virus

<400>  1

Leu Pro Met Leu Pro Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg 
1               5                   10                  15      


Arg Gly Arg Arg Ser Gly Gly Ala Gly Gly Gly Phe Trp Gly Asp Arg 
            20                  25                  30          


Val Asp Ser Gln Pro Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro 
        35                  40                  45              


Phe Ala Ala Asp Ile Val Ser Gln Ser Gly Ala Gly Thr Arg Pro Arg 
    50                  55                  60                  


Gln Pro Pro Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg 
65                  70                  75                  80  


Pro Ser Ala Ala Pro Arg Arg Arg Ser Ala Pro Ala Gly Ala Ala Pro 
                85                  90                  95      


Leu Thr Ala Val Ser Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val 
            100                 105                 110         


Asp Ser Arg Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser 
        115                 120                 125             


Pro Leu Thr Ser Ser Val Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala 
    130                 135                 140                 


Ala Pro Leu Asn Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His 
145                 150                 155                 160 


Ile Met Ala Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg 
                165                 170                 175     


Ala Thr Ile Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr 
            180                 185                 190         


Ala Ile Ser Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser 
        195                 200                 205             


Val Asp Met Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln 
    210                 215                 220                 


Pro Gly Ile Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr 
225                 230                 235                 240 


Arg Asn Gln Gly Trp Arg Ser Val Glu Thr Thr Gly Val Ala Glu Glu 
                245                 250                 255     


Glu Ala Thr Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val 
            260                 265                 270         


Asn Ser Tyr Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp 
        275                 280                 285             


Phe Ala Leu Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn 
    290                 295                 300                 


Thr Arg Val Ser Arg Tyr Thr Ser Thr Ala Arg His Arg Leu Arg Arg 
305                 310                 315                 320 


Gly Ala Asp Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe 
                325                 330                 335     


Met Lys Asp Leu His Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly 
            340                 345                 350         


Arg Gly Ile Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly 
        355                 360                 365             


Gly Leu Pro Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr 
    370                 375                 380                 


Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr 
385                 390                 395                 400 


Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile Thr Ile Pro His 
                405                 410                 415     


Asp Ile Asp Leu Gly Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn 
            420                 425                 430         


Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro 
        435                 440                 445             


Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala 
    450                 455                 460                 


Ala Glu Tyr Asp Gln Ala Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr 
465                 470                 475                 480 


Val Ser Asp Thr Val Thr Phe Val Asn Val Ala Thr Gly Ala Gln Ala 
                485                 490                 495     


Val Ala Arg Ser Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro 
            500                 505                 510         


Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Tyr Val Leu Pro Leu 
        515                 520                 525             


Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr Arg Ala Gly Tyr 
    530                 535                 540                 


Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn 
545                 550                 555                 560 


Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly 
                565                 570                 575     


Ala Gly Pro Ala Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ser 
            580                 585                 590         


Ala Leu Ala Val Leu Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His 
        595                 600                 605             


Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Thr Leu Gly Leu Gln Gly 
    610                 615                 620                 


Cys Ala Phe Gln Ser Thr Ile Ala Glu Leu Gln Arg Leu Lys Thr Glu 
625                 630                 635                 640 


Val Gly Lys Thr Arg Glu Ser 
                645         


<210>  2
<211>  627
<212>  PRT
<213>  Hepatitis E virus

<400>  2

Ser Gly Gly Ala Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser Gln 
1               5                   10                  15      


Pro Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ala Asp 
            20                  25                  30          


Ile Val Ser Gln Ser Gly Ala Gly Thr Arg Pro Arg Gln Pro Pro Arg 
        35                  40                  45              


Pro Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ser Ala Ala 
    50                  55                  60                  


Pro Arg Arg Arg Ser Ala Pro Ala Gly Ala Ala Pro Leu Thr Ala Val 
65                  70                  75                  80  


Ser Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg Gly 
                85                  90                  95      


Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr Ser 
            100                 105                 110         


Ser Val Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu Asn 
        115                 120                 125             


Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala Thr 
    130                 135                 140                 


Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile Arg 
145                 150                 155                 160 


Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser Ile 
                165                 170                 175     


Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met Asn 
            180                 185                 190         


Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile Ala 
        195                 200                 205             


Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln Gly 
    210                 215                 220                 


Trp Arg Ser Val Glu Thr Thr Gly Val Ala Glu Glu Glu Ala Thr Ser 
225                 230                 235                 240 


Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr Thr 
                245                 250                 255     


Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu Glu 
            260                 265                 270         


Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val Ser 
        275                 280                 285             


Arg Tyr Thr Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp Gly 
    290                 295                 300                 


Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu 
305                 310                 315                 320 


His Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile Ala 
                325                 330                 335     


Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr 
            340                 345                 350         


Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val 
        355                 360                 365             


Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu 
    370                 375                 380                 


Asn Ala Gln Gln Asp Lys Gly Ile Thr Ile Pro His Asp Ile Asp Leu 
385                 390                 395                 400 


Gly Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln 
                405                 410                 415     


Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu 
            420                 425                 430         


Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp 
        435                 440                 445             


Gln Ala Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr 
    450                 455                 460                 


Val Thr Phe Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg Ser 
465                 470                 475                 480 


Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr Ile 
                485                 490                 495     


Gln Gln Tyr Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys Leu 
            500                 505                 510         


Ser Phe Trp Glu Ala Gly Thr Thr Arg Ala Gly Tyr Pro Tyr Asn Tyr 
        515                 520                 525             


Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His 
    530                 535                 540                 


Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro Ala 
545                 550                 555                 560 


Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Val 
                565                 570                 575     


Leu Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp Asp 
            580                 585                 590         


Phe Cys Pro Glu Cys Arg Thr Leu Gly Leu Gln Gly Cys Ala Phe Gln 
        595                 600                 605             


Ser Thr Ile Ala Glu Leu Gln Arg Leu Lys Thr Glu Val Gly Lys Thr 
    610                 615                 620                 


Arg Glu Ser 
625         


<210>  3
<211>  559
<212>  PRT
<213>  Hepatitis E virus

<400>  3

Ser Ala Pro Ala Gly Ala Ala Pro Leu Thr Ala Val Ser Pro Ala Pro 
1               5                   10                  15      


Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg Gly Ala Ile Leu Arg 
            20                  25                  30          


Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr Ser Ser Val Ala Ser 
        35                  40                  45              


Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu Asn Pro Leu Leu Pro 
    50                  55                  60                  


Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala Thr Glu Ala Ser Asn 
65                  70                  75                  80  


Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile Arg Tyr Arg Pro Leu 
                85                  90                  95      


Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser Ile Ser Phe Trp Pro 
            100                 105                 110         


Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met Asn Ser Ile Thr Ser 
        115                 120                 125             


Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile Ala Ser Glu Leu Val 
    130                 135                 140                 


Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln Gly Trp Arg Ser Val 
145                 150                 155                 160 


Glu Thr Thr Gly Val Ala Glu Glu Glu Ala Thr Ser Gly Leu Val Met 
                165                 170                 175     


Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr Thr Asn Thr Pro Tyr 
            180                 185                 190         


Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu Glu Leu Glu Phe Arg 
        195                 200                 205             


Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val Ser Arg Tyr Thr Ser 
    210                 215                 220                 


Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp Gly Thr Ala Glu Leu 
225                 230                 235                 240 


Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu His Phe Thr Gly 
                245                 250                 255     


Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile Ala Leu Thr Leu Phe 
            260                 265                 270         


Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr Glu Leu Ile Ser 
        275                 280                 285             


Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn 
    290                 295                 300                 


Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln 
305                 310                 315                 320 


Asp Lys Gly Ile Thr Ile Pro His Asp Ile Asp Leu Gly Asp Ser Arg 
                325                 330                 335     


Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr 
            340                 345                 350         


Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp 
        355                 360                 365             


Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln Ala Thr Tyr 
    370                 375                 380                 


Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val 
385                 390                 395                 400 


Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Ser 
                405                 410                 415     


Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser 
            420                 425                 430         


Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu 
        435                 440                 445             


Ala Gly Thr Thr Arg Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala 
    450                 455                 460                 


Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg Val Ala Ile 
465                 470                 475                 480 


Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro Ala Ser Ile Ser Ala 
                485                 490                 495     


Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Val Leu Glu Asp Thr 
            500                 505                 510         


Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu 
        515                 520                 525             


Cys Arg Thr Leu Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Ile Ala 
    530                 535                 540                 


Glu Leu Gln Arg Leu Lys Thr Glu Val Gly Lys Thr Arg Glu Ser 
545                 550                 555                 


<210>  4
<211>  14
<212>  PRT
<213>  Hepatitis E virus

<400>  4

Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg Arg Ser Gly Gly 
1               5                   10                  


