                         SEQUENCE LISTING

<110>  Arzeda Corp.
 
<120>  METHODS AND COMPOSITIONS FOR PREPARING TAGATOSE FROM FRUCTOSE

<130>  ARZE-028/01WO 311023-2114

<150>  US 62/693,681
<151>  2018-07-03

<150>  US 62/693,660
<151>  2018-07-03

<160>  444   

<170>  PatentIn version 3.5

<210>  1
<211>  453
<212>  PRT
<213>  Caldithrix abyssi

<400>  1

Met Ser Leu His Pro Leu Asn Lys Leu Ile Glu Arg His Lys Lys Gly 
1               5                   10                  15      


Thr Pro Val Gly Ile Tyr Ser Val Cys Ser Ala Asn Pro Phe Val Leu 
            20                  25                  30          


Lys Ala Ala Met Leu Gln Ala Gln Lys Asp Gln Ser Leu Leu Leu Ile 
        35                  40                  45              


Glu Ala Thr Ser Asn Gln Val Asp Gln Phe Gly Gly Tyr Thr Gly Met 
    50                  55                  60                  


Arg Pro Glu Asp Phe Lys Thr Met Thr Leu Glu Leu Ala Ala Glu Asn 
65                  70                  75                  80  


Asn Tyr Asp Pro Gln Gly Leu Ile Leu Gly Gly Asp His Leu Gly Pro 
                85                  90                  95      


Asn Arg Trp Thr Lys Leu Ser Ala Ser Arg Ala Met Asp Tyr Ala Arg 
            100                 105                 110         


Glu Gln Ile Ala Ala Tyr Val Lys Ala Gly Phe Ser Lys Ile His Leu 
        115                 120                 125             


Asp Ala Thr Met Pro Leu Gln Asn Asp Ala Thr Asp Ser Ala Gly Arg 
    130                 135                 140                 


Leu Pro Val Glu Thr Ile Ala Gln Arg Thr Ala Glu Leu Cys Ala Val 
145                 150                 155                 160 


Ala Glu Gln Thr Tyr Arg Gln Ser Asp Gln Leu Phe Pro Pro Pro Val 
                165                 170                 175     


Tyr Ile Val Gly Ser Asp Val Pro Ile Pro Gly Gly Ala Gln Glu Ala 
            180                 185                 190         


Leu Asn Gln Ile His Ile Thr Glu Val Lys Glu Val Gln Gln Thr Ile 
        195                 200                 205             


Asp His Val Arg Arg Ala Phe Glu Lys Asn Gly Leu Glu Ala Ala Tyr 
    210                 215                 220                 


Glu Arg Val Cys Ala Val Val Val Gln Pro Gly Val Glu Phe Ala Asp 
225                 230                 235                 240 


Gln Ile Val Phe Glu Tyr Ala Pro Asp Arg Ala Ala Ala Leu Lys Asp 
                245                 250                 255     


Phe Ile Glu Ser His Ser Gln Leu Val Tyr Glu Ala His Ser Thr Asp 
            260                 265                 270         


Tyr Gln Thr Ala Pro Leu Leu Arg Gln Met Val Lys Asp His Phe Ala 
        275                 280                 285             


Ile Leu Lys Val Gly Pro Ala Leu Thr Phe Ala Leu Arg Glu Ala Ile 
    290                 295                 300                 


Phe Ala Leu Ala Phe Met Glu Lys Glu Leu Leu Pro Leu His Arg Ala 
305                 310                 315                 320 


Leu Lys Pro Ser Ala Ile Leu Glu Thr Leu Asp Gln Thr Met Asp Lys 
                325                 330                 335     


Asn Pro Ala Tyr Trp Gln Lys His Tyr Gly Gly Thr Lys Glu Glu Val 
            340                 345                 350         


Arg Phe Ala Gln Arg Phe Ser Leu Ser Asp Arg Ile Arg Tyr Tyr Trp 
        355                 360                 365             


Pro Phe Pro Lys Val Gln Lys Ala Leu Arg Gln Leu Leu Lys Asn Leu 
    370                 375                 380                 


Gln Gln Ile Ser Ile Pro Leu Thr Leu Val Ser Gln Phe Met Pro Glu 
385                 390                 395                 400 


Glu Tyr Gln Arg Ile Arg Gln Gly Thr Leu Thr Asn Asp Pro Gln Ala 
                405                 410                 415     


Leu Ile Leu Asn Lys Ile Gln Ser Val Leu Lys Gln Tyr Ala Glu Ala 
            420                 425                 430         


Thr Gln Ile Gln Asn Ser Leu Thr Phe Thr Gln Asn Gln Asn Ser Leu 
        435                 440                 445             


Ala Met Glu Arg Leu 
    450             


<210>  2
<211>  429
<212>  PRT
<213>  Anaerolinea thermophila

<400>  2

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  3
<211>  434
<212>  PRT
<213>  Thermoanaerobacterium thermosaccharolyticum

<400>  3

Met Ala Lys Glu His Pro Leu Lys Glu Leu Val Asn Lys Gln Lys Ser 
1               5                   10                  15      


Gly Ile Ser Glu Gly Ile Val Ser Ile Cys Ser Ser Asn Glu Phe Val 
            20                  25                  30          


Ile Glu Ala Ser Met Glu Arg Ala Leu Thr Asn Gly Asp Tyr Val Leu 
        35                  40                  45              


Ile Glu Ser Thr Ala Asn Gln Val Asn Gln Tyr Gly Gly Tyr Ile Gly 
    50                  55                  60                  


Met Thr Pro Ile Glu Phe Lys Lys Phe Val Phe Ser Ile Ala Lys Lys 
65                  70                  75                  80  


Val Asp Phe Pro Leu Asp Lys Leu Ile Leu Gly Gly Asp His Leu Gly 
                85                  90                  95      


Pro Leu Ile Trp Lys Asn Glu Ser Ser Asn Leu Ala Leu Ala Lys Ala 
            100                 105                 110         


Ser Glu Leu Ile Lys Glu Tyr Val Leu Ala Gly Tyr Thr Lys Ile His 
        115                 120                 125             


Ile Asp Thr Ser Met Arg Leu Lys Asp Asp Thr Asp Phe Asn Thr Glu 
    130                 135                 140                 


Ile Ile Ala Gln Arg Ser Ala Val Leu Leu Lys Ala Ala Glu Asn Ala 
145                 150                 155                 160 


Tyr Met Glu Leu Asn Lys Asn Asn Lys Asn Val Leu His Pro Val Tyr 
                165                 170                 175     


Val Ile Gly Ser Glu Val Pro Ile Pro Gly Gly Ser Gln Gly Ser Asp 
            180                 185                 190         


Glu Ser Leu Gln Ile Thr Asp Ala Lys Asp Phe Glu Asn Thr Val Glu 
        195                 200                 205             


Ile Phe Lys Asp Val Phe Ser Lys Tyr Gly Leu Ile Asn Glu Trp Glu 
    210                 215                 220                 


Asn Ile Val Ala Phe Val Val Gln Pro Gly Val Glu Phe Gly Asn Asp 
225                 230                 235                 240 


Phe Val His Glu Tyr Lys Arg Asp Glu Ala Lys Glu Leu Thr Asp Ala 
                245                 250                 255     


Leu Lys Asn Tyr Lys Thr Phe Val Phe Glu Gly His Ser Thr Asp Tyr 
            260                 265                 270         


Gln Thr Arg Glu Ser Leu Lys Gln Met Val Glu Asp Gly Ile Ala Ile 
        275                 280                 285             


Leu Lys Val Gly Pro Ala Leu Thr Phe Ala Leu Arg Glu Ala Leu Ile 
    290                 295                 300                 


Ala Leu Asn Asn Ile Glu Asn Glu Leu Leu Asn Asn Val Asp Ser Ile 
305                 310                 315                 320 


Lys Leu Ser Asn Phe Thr Asn Val Leu Val Ser Glu Met Ile Asn Asn 
                325                 330                 335     


Pro Glu His Trp Lys Asn His Tyr Phe Gly Asp Asp Ala Arg Lys Lys 
            340                 345                 350         


Phe Leu Cys Lys Tyr Ser Tyr Ser Asp Arg Cys Arg Tyr Tyr Leu Pro 
        355                 360                 365             


Thr Arg Asn Val Lys Asn Ser Leu Asn Leu Leu Ile Arg Asn Leu Glu 
    370                 375                 380                 


Asn Val Lys Ile Pro Met Thr Leu Ile Ser Gln Phe Met Pro Leu Gln 
385                 390                 395                 400 


Tyr Asp Asn Ile Arg Arg Gly Leu Ile Lys Asn Glu Pro Ile Ser Leu 
                405                 410                 415     


Ile Lys Asn Ala Ile Met Asn Arg Leu Asn Asp Tyr Tyr Tyr Ala Ile 
            420                 425                 430         


Lys Pro 
        


<210>  4
<211>  446
<212>  PRT
<213>  Thermoanaerobacter thermohydrosulfuricus

<400>  4

Met Asn Thr Glu His Pro Leu Lys Asn Val Val Lys Leu Gln Lys Lys 
1               5                   10                  15      


Gly Ile Pro Ile Gly Ile Tyr Ser Val Cys Ser Ala Asn Glu Ile Val 
            20                  25                  30          


Ile Gln Val Ala Met Glu Lys Ala Leu Ser Met Asp Ser Tyr Val Leu 
        35                  40                  45              


Ile Glu Ala Thr Ala Asn Gln Val Asn Gln Tyr Gly Gly Tyr Thr Asn 
    50                  55                  60                  


Met Lys Pro Ile Asp Phe Arg Asp Phe Val Tyr Ser Ile Ala Lys Arg 
65                  70                  75                  80  


Ile Asn Phe Pro Glu Asn Arg Ile Ile Leu Gly Gly Asp His Leu Gly 
                85                  90                  95      


Pro Leu Pro Trp Lys Asn Gln Gln Ala Lys Lys Ala Met Glu Glu Ala 
            100                 105                 110         


Lys Glu Leu Val Lys Gln Phe Val Met Ala Gly Phe Thr Lys Ile His 
        115                 120                 125             


Val Asp Thr Ser Met Leu Leu Gly Asp Asp Asn Ile Asn Ile Lys Leu 
    130                 135                 140                 


Asp Thr Glu Thr Ile Ala Glu Arg Gly Ala Ile Leu Val Ser Val Ala 
145                 150                 155                 160 


Glu Arg Ala Phe Glu Glu Leu Lys Lys Phe Asn Pro Tyr Ala Leu His 
                165                 170                 175     


Pro Val Tyr Val Ile Gly Ser Glu Val Pro Val Pro Gly Gly Ser Gln 
            180                 185                 190         


Lys Glu Asn Asn Asn Glu Ile Gln Val Thr Lys Pro Thr Asp Phe Glu 
        195                 200                 205             


Glu Thr Val Glu Val Tyr Lys Ser Thr Phe Tyr Lys Tyr Gly Leu Gly 
    210                 215                 220                 


Asn Ala Trp Glu Asp Val Val Ala Val Val Val Gln Ala Gly Val Glu 
225                 230                 235                 240 


Phe Gly Val Glu Asp Ile His Glu Tyr Asp His Gln Gln Ala Glu Asn 
                245                 250                 255     


Leu Val Ser Ala Leu Lys Lys Tyr Pro Asn Leu Val Phe Glu Ala His 
            260                 265                 270         


Ser Thr Asp Tyr Gln Pro Ala Lys Leu Leu Lys Glu Met Val Arg Asp 
        275                 280                 285             


Gly Phe Ala Ile Leu Lys Val Gly Pro Glu Leu Thr Phe Ala Leu Arg 
    290                 295                 300                 


Glu Gly Leu Phe Ala Leu Asn Ile Ile Glu Lys Glu Leu Phe Lys Asp 
305                 310                 315                 320 


Asn His Asp Ile Glu Met Ser Asn Phe Ile Asp Ile Leu Asp Thr Ala 
                325                 330                 335     


Met Leu Asn Asn Pro Lys Tyr Trp Glu Gln Tyr Tyr Tyr Gly Asp Asp 
            340                 345                 350         


Asn Lys Ile Arg Ile Ala Arg Lys Tyr Ser Tyr Ser Asp Arg Cys Arg 
        355                 360                 365             


Tyr Tyr Leu Ile Glu Asn Glu Val Arg Ala Ser Met Ser Arg Leu Phe 
    370                 375                 380                 


Lys Asn Leu Thr Asn Val Glu Ile Pro Leu Thr Leu Ile Ser Gln Tyr 
385                 390                 395                 400 


Met Pro Ile Gln Tyr Glu Lys Ile Arg Met Gly Leu Leu Lys Asn Asp 
                405                 410                 415     


Pro Glu Asn Leu Val Lys Asp Lys Ile Gly Asn Cys Ile Asp Lys Tyr 
            420                 425                 430         


Leu Tyr Ala Thr Asn Pro Thr Ser Gly Glu Phe Lys Leu Ile 
        435                 440                 445     


<210>  5
<211>  429
<212>  PRT
<213>  Caldicellulosiruptor kronotskyensis

<400>  5

Met Ser Pro Gln Asn Pro Leu Ile Gly Leu Phe Lys Asn Arg Glu Lys 
1               5                   10                  15      


Glu Phe Lys Gly Ile Ile Ser Val Cys Ser Ser Asn Glu Ile Val Leu 
            20                  25                  30          


Glu Ala Val Leu Lys Arg Met Lys Asp Thr Asn Leu Pro Ile Ile Ile 
        35                  40                  45              


Glu Ala Thr Ala Asn Gln Val Asn Gln Phe Gly Gly Tyr Ser Gly Leu 
    50                  55                  60                  


Thr Pro Ser Gln Phe Lys Glu Arg Val Ile Lys Ile Ala Gln Lys Val 
65                  70                  75                  80  


Asp Phe Pro Leu Glu Arg Ile Ile Leu Gly Gly Asp His Leu Gly Pro 
                85                  90                  95      


Phe Val Trp Arg Asp Gln Glu Pro Glu Ile Ala Met Glu Tyr Ala Lys 
            100                 105                 110         


Gln Met Ile Lys Glu Tyr Ile Lys Ala Gly Phe Thr Lys Ile His Ile 
        115                 120                 125             


Asp Thr Ser Met Pro Leu Lys Gly Glu Asn Ser Ile Asp Asp Glu Ile 
    130                 135                 140                 


Ile Ala Lys Arg Thr Ala Val Leu Cys Arg Ile Ala Glu Glu Cys Phe 
145                 150                 155                 160 


Glu Lys Ile Ser Ile Asn Asn Pro Tyr Ile Thr Arg Pro Val Tyr Val 
                165                 170                 175     


Ile Gly Ala Asp Val Pro Pro Pro Gly Gly Glu Ser Ser Ile Cys Gln 
            180                 185                 190         


Thr Ile Thr Thr Lys Asp Glu Leu Glu Arg Ser Leu Glu Tyr Phe Lys 
        195                 200                 205             


Glu Ala Phe Lys Lys Glu Gly Ile Glu His Val Phe Asp Tyr Val Val 
    210                 215                 220                 


Ala Val Val Ala Asn Phe Gly Val Glu Phe Gly Ser Asp Glu Ile Val 
225                 230                 235                 240 


Asp Phe Asp Met Glu Lys Val Lys Pro Leu Lys Glu Leu Leu Ala Lys 
                245                 250                 255     


Tyr Asn Ile Val Phe Glu Gly His Ser Thr Asp Tyr Gln Thr Lys Glu 
            260                 265                 270         


Asn Leu Lys Arg Met Val Glu Cys Gly Ile Ala Ile Leu Lys Val Gly 
        275                 280                 285             


Pro Ala Leu Thr Phe Thr Leu Arg Glu Ala Leu Val Ala Leu Ser His 
    290                 295                 300                 


Ile Glu Glu Glu Ile Tyr Ser Asn Glu Lys Glu Lys Leu Ser Arg Phe 
305                 310                 315                 320 


Arg Glu Val Leu Leu Asn Thr Met Leu Thr Cys Lys Asp His Trp Ser 
                325                 330                 335     


Lys Tyr Phe Asp Glu Asn Asp Lys Leu Ile Lys Ser Lys Leu Leu Tyr 
            340                 345                 350         


Ser Tyr Leu Asp Arg Trp Arg Tyr Tyr Phe Glu Asn Glu Ser Val Lys 
        355                 360                 365             


Ser Ala Val Tyr Ser Leu Ile Gly Asn Leu Glu Asn Val Lys Ile Pro 
    370                 375                 380                 


Pro Trp Leu Val Ser Gln Tyr Phe Pro Ser Gln Tyr Gln Lys Met Arg 
385                 390                 395                 400 


Lys Lys Asp Leu Lys Asn Gly Ala Ala Asp Leu Ile Leu Asp Lys Ile 
                405                 410                 415     


Gly Glu Val Ile Asp His Tyr Val Tyr Ala Val Lys Glu 
            420                 425                 


<210>  6
<211>  408
<212>  PRT
<213>  Dictyoglomus turgidum

<400>  6

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  7
<211>  408
<212>  PRT
<213>  Caldilinea aerophila

<400>  7

Met Ser Thr Leu Arg His Ile Ile Leu Arg Leu Ile Glu Leu Arg Glu 
1               5                   10                  15      


Arg Glu Gln Ile His Leu Thr Leu Leu Ala Val Cys Pro Asn Ser Ala 
            20                  25                  30          


Ala Val Leu Glu Ala Ala Val Lys Val Ala Ala Arg Cys His Thr Pro 
        35                  40                  45              


Met Leu Phe Ala Ala Thr Leu Asn Gln Val Asp Arg Asp Gly Gly Tyr 
    50                  55                  60                  


Thr Gly Trp Thr Pro Ala Gln Phe Val Ala Glu Met Arg Arg Tyr Ala 
65                  70                  75                  80  


Val Arg Tyr Gly Cys Thr Thr Pro Leu Tyr Pro Cys Leu Asp His Gly 
                85                  90                  95      


Gly Pro Trp Leu Lys Asp Arg His Ala Gln Glu Lys Leu Pro Leu Asp 
            100                 105                 110         


Gln Ala Met His Glu Val Lys Leu Ser Leu Thr Ala Cys Leu Glu Ala 
        115                 120                 125             


Gly Tyr Ala Leu Leu His Ile Asp Pro Thr Val Asp Arg Thr Leu Pro 
    130                 135                 140                 


Pro Gly Glu Ala Pro Leu Val Pro Ile Val Val Glu Arg Thr Val Glu 
145                 150                 155                 160 


Leu Ile Glu His Ala Glu Gln Glu Arg Gln Arg Leu Asn Leu Pro Ala 
                165                 170                 175     


Val Ala Tyr Glu Val Gly Thr Glu Glu Val His Gly Gly Leu Val Asn 
            180                 185                 190         


Phe Asp Asn Phe Val Ala Phe Leu Asp Leu Leu Lys Ala Arg Leu Glu 
        195                 200                 205             


Gln Arg Ala Leu Met His Ala Trp Pro Ala Phe Val Val Ala Gln Val 
    210                 215                 220                 


Gly Thr Asp Leu His Thr Thr Tyr Phe Asp Pro Ser Ala Ala Gln Arg 
225                 230                 235                 240 


Leu Thr Glu Ile Val Arg Pro Thr Gly Ala Leu Leu Lys Gly His Tyr 
                245                 250                 255     


Thr Asp Trp Val Glu Asn Pro Ala Asp Tyr Pro Arg Val Gly Met Gly 
            260                 265                 270         


Gly Ala Asn Val Gly Pro Glu Phe Thr Ala Ala Glu Phe Glu Ala Leu 
        275                 280                 285             


Glu Ala Leu Glu Arg Arg Glu Gln Arg Leu Cys Ala Asn Arg Lys Leu 
    290                 295                 300                 


Gln Pro Ala Cys Phe Leu Ala Ala Leu Glu Glu Ala Val Val Ala Ser 
305                 310                 315                 320 


Asp Arg Trp Arg Lys Trp Leu Gln Pro Asp Glu Ile Gly Lys Pro Phe 
                325                 330                 335     


Ala Glu Leu Thr Pro Ala Arg Arg Arg Trp Leu Val Gln Thr Gly Ala 
            340                 345                 350         


Arg Tyr Val Trp Thr Ala Pro Lys Val Ile Ala Ala Arg Glu Gln Leu 
        355                 360                 365             


Tyr Ala His Leu Ser Leu Val Gln Ala Asp Pro His Ala Tyr Val Val 
    370                 375                 380                 


Glu Ser Val Ala Arg Ser Ile Glu Arg Tyr Ile Asp Ala Phe Asn Leu 
385                 390                 395                 400 


Tyr Asp Ala Ala Thr Leu Leu Gly 
                405             


<210>  8
<211>  420
<212>  PRT
<213>  Rhodothermus marinus

<400>  8

Met Gln Ala Gln Ala Leu Leu Thr Val Pro Phe Asp Arg Val Ala Thr 
1               5                   10                  15      


His Ala Arg Gly Phe Val Gly Trp Val Ala Glu Leu Leu Gln Gly Pro 
            20                  25                  30          


Leu Ala Tyr Gln His Thr Leu Leu Ala Val Cys Pro Asn Ser Glu Ala 
        35                  40                  45              


Val Thr Arg Ala Ala Leu Glu Ala Ala Ala Glu Ala Asn Ala Pro Leu 
    50                  55                  60                  


Leu Phe Ala Ala Thr Leu Asn Gln Val Asp Leu Asp Gly Gly Tyr Thr 
65                  70                  75                  80  


Gly Trp Thr Pro Ala Thr Leu Ala Arg Phe Val Ala Asp Glu Leu Ala 
                85                  90                  95      


Arg Leu Asp Leu His Ile Pro Val Val Leu Gly Leu Asp His Gly Gly 
            100                 105                 110         


Pro Trp Lys Lys Asp Leu His Ala Arg Asn Arg Leu Ser Phe Glu Glu 
        115                 120                 125             


Thr Phe Gln Ala Val Leu Arg Ala Ile Glu Ala Cys Leu Asp Ala Gly 
    130                 135                 140                 


Tyr Gly Leu Leu His Leu Asp Pro Thr Val Asp Leu Glu Leu Ser Pro 
145                 150                 155                 160 


Gly Thr Pro Val Pro Ile Pro Arg Ile Val Glu Arg Ser Val Ala Leu 
                165                 170                 175     


Leu Arg His Ala Glu Thr Tyr Arg Leu Arg Arg Asn Leu Pro Pro Val 
            180                 185                 190         


Ala Tyr Glu Val Gly Thr Glu Glu Val Gly Gly Gly Leu Gln Ala Glu 
        195                 200                 205             


Ala Arg Met Ala Glu Phe Leu Asp Arg Leu Trp Thr Ala Leu Asp Arg 
    210                 215                 220                 


Glu Gly Leu Pro His Pro Val Phe Val Val Gly Asp Ile Gly Thr Arg 
225                 230                 235                 240 


Leu Asp Thr Arg Thr Phe Asp Phe Glu Arg Ala Arg Arg Leu Asp Ala 
                245                 250                 255     


Leu Val Arg Arg Tyr Gly Ala Leu Ile Lys Gly His Tyr Thr Asp Asp 
            260                 265                 270         


Val Asp Arg Leu Asp Leu Tyr Pro Lys Ala Gly Ile Gly Gly Ala Asn 
        275                 280                 285             


Val Gly Pro Gly Leu Ala Ala Ile Glu Phe Glu Ala Leu Glu Ala Leu 
    290                 295                 300                 


Val Glu Glu Ala Arg Arg Arg Gly Leu Ser Val Thr Phe Asp Gln Ala 
305                 310                 315                 320 


Ile Arg Arg Ala Val Val Glu Ser Gly Arg Trp Thr Lys Trp Leu Gln 
                325                 330                 335     


Pro Glu Glu Lys Gly Gln Pro Phe Asp Ala Leu Asp Pro Glu Arg Gln 
            340                 345                 350         


Arg Trp Leu Val Ala Thr Gly Ser Arg Tyr Val Trp Thr His Pro Ala 
        355                 360                 365             


Val Leu Gln Ala Arg Arg Glu Leu Tyr Glu Ala Leu Ala Pro Trp Leu 
    370                 375                 380                 


Asp Ala Asp Ala Phe Val Arg Thr Arg Ile Lys Ala Arg Leu Met Asp 
385                 390                 395                 400 


Tyr Phe Arg Ala Phe Asn Leu Ile His Phe Asn Glu Arg Leu Gln Ala 
                405                 410                 415     


Phe Leu Pro Glu 
            420 


<210>  9
<211>  401
<212>  PRT
<213>  Methanohalobium evestigatum

<400>  9

Met Thr Asp Glu Asp Phe Glu Pro Ile Cys Glu Ile Ser Glu Gln Phe 
1               5                   10                  15      


Arg Asn Tyr Cys Asn Gln Met Leu Glu Ser Glu Tyr Asp Pro Lys Pro 
            20                  25                  30          


Ser Lys Tyr Ile Phe Asn Ile Leu Gln Asn Gln Lys Thr Ile Val Met 
        35                  40                  45              


Ala Ala Asn Pro Arg Ile Gly Leu Val Thr Arg Gly Ile Leu Arg Ala 
    50                  55                  60                  


Ala Lys Asp Ala Asp Ala Pro Ile Ile Leu Glu Leu Ala Arg Ser Glu 
65                  70                  75                  80  


Cys Asn Leu Glu Asn Gly Tyr Thr Gly Leu Tyr Pro Ser Asp Phe Ser 
                85                  90                  95      


Glu Gln Cys Tyr Gln Ala Ala Lys Asp Val Gly Tyr Asp Ile Trp Ala 
            100                 105                 110         


Leu His Ala Asp His Ile Gly Ile Lys Lys Gly Asp Arg Glu Asp Ile 
        115                 120                 125             


Glu Lys Thr Lys Glu Leu Val Lys Ala Gln Ile Asp Ala Gly Tyr Thr 
    130                 135                 140                 


Ser Phe Ala Ile Asp Ala Ser His Leu Phe Asn Phe Gln Gly Gly Asp 
145                 150                 155                 160 


Leu Arg Glu Glu Leu Lys Asp Asn Ile Asp Ala Thr Thr Glu Ile Ala 
                165                 170                 175     


Lys Phe Ile Glu Glu Gln Met Asp Asp Arg Glu Tyr Gly Leu Glu Val 
            180                 185                 190         


Glu Val Gly Glu Ile Gly Arg Glu Asp Glu His Gly Arg Val Leu Thr 
        195                 200                 205             


Asn Pro Glu Glu Ala Val Thr Phe Ile Lys Ala Leu Asn Glu Asn Gly 
    210                 215                 220                 


Val Tyr Pro Gln Val Leu Ala Ile Ala Asn Gly Ser Ala His Gly Asn 
225                 230                 235                 240 


Thr Tyr Asp Ser Gln Gly Arg Leu Ile Glu Gln Val Ser Ile Asp Ile 
                245                 250                 255     


Pro Gln Thr Ile Lys Val Ala Gln Ala Leu Lys Glu Asn Asn Leu Lys 
            260                 265                 270         


Val Arg Ile Ala Gln His Gly Ile Thr Gly Thr Pro Arg Glu Leu Ile 
        275                 280                 285             


His Asp His Phe Pro His Gly Glu Ile Ile Lys Gly Asn Val Gly Thr 
    290                 295                 300                 


Phe Tyr Met Asn Leu Val Trp Asp Ala Phe Lys Leu Phe Glu Pro Glu 
305                 310                 315                 320 


Leu Tyr Asn Asp Ile Trp Asn Trp Thr Val Glu Asn Tyr Lys Gln Lys 
                325                 330                 335     


Ser Pro Asp Lys Thr Asp Ser Glu Ile Phe Gly Lys Tyr Ser Lys Phe 
            340                 345                 350         


Ala Ile Lys Gln Phe Phe Asp Arg Ile Tyr Ser Val Asn Glu Asp Thr 
        355                 360                 365             


Lys Arg Ala Ile Asp Ala Met Ala Tyr Ala Glu Thr Leu Tyr Phe Leu 
    370                 375                 380                 


Lys Ser Phe Asn Ala Glu Arg Thr Ala Ser Ile Val Arg Asp Gly Ile 
385                 390                 395                 400 


Lys 
    


<210>  10
<211>  343
<212>  PRT
<213>  Thermoanaerobacter thermohydrosulfuricus

<400>  10

Met Asn Thr Glu His Pro Leu Lys Asn Val Val Lys Leu Gln Lys Lys 
1               5                   10                  15      


Gly Ile Pro Ile Gly Ile Tyr Ser Val Cys Ser Ala Asn Glu Ile Val 
            20                  25                  30          


Ile Gln Val Ala Met Glu Lys Ala Leu Ser Met Asp Ser Tyr Val Leu 
        35                  40                  45              


Ile Glu Ala Thr Ala Asn Gln Val Asn Gln Tyr Gly Gly Tyr Thr Asn 
    50                  55                  60                  


Met Lys Pro Ile Asp Phe Arg Asp Phe Val Tyr Ser Ile Ala Lys Arg 
65                  70                  75                  80  


Ile Asn Phe Pro Glu Asn Arg Ile Ile Leu Gly Gly Asp His Leu Gly 
                85                  90                  95      


Pro Leu Pro Trp Lys Asn Gln Gln Ala Lys Lys Ala Met Glu Glu Ala 
            100                 105                 110         


Lys Glu Leu Val Lys Gln Phe Val Met Ala Gly Phe Thr Lys Ile His 
        115                 120                 125             


Val Asp Thr Ser Met Phe Leu Gly Asp Asp Asn Ile Asn Ile Lys Leu 
    130                 135                 140                 


Asp Thr Glu Thr Ile Ala Glu Arg Gly Ala Ile Leu Val Ser Val Ala 
145                 150                 155                 160 


Glu Arg Ala Phe Glu Glu Leu Lys Lys Ser Asn Pro Tyr Ala Leu His 
                165                 170                 175     


Pro Val Tyr Val Ile Gly Ser Glu Val Pro Val Pro Gly Gly Ser Gln 
            180                 185                 190         


Lys Glu Asn Asn Asn Glu Ile Gln Val Thr Lys Pro Ala Asp Phe Glu 
        195                 200                 205             


Glu Thr Val Glu Val Tyr Lys Ser Thr Phe Tyr Lys Tyr Gly Leu Gly 
    210                 215                 220                 


Asn Ala Trp Glu Asp Val Val Ala Val Val Val Gln Pro Gly Val Glu 
225                 230                 235                 240 


Phe Gly Val Glu Asn Ile His Glu Tyr Asp His Gln Gln Ala Glu Asn 
                245                 250                 255     


Leu Val Ser Ala Leu Lys Lys Tyr Pro Asn Leu Val Phe Glu Ala His 
            260                 265                 270         


Ser Thr Asp Tyr Gln Pro Ala Lys Leu Leu Lys Glu Met Val Arg Asp 
        275                 280                 285             


Gly Phe Ala Ile Leu Lys Val Gly Pro Glu Leu Thr Phe Ala Leu Arg 
    290                 295                 300                 


Glu Gly Leu Phe Ala Leu Asn Ile Ile Glu Lys Glu Leu Phe Lys Asp 
305                 310                 315                 320 


Asn His Asp Ile Glu Met Ser Asn Phe Ile Asp Ile Leu Asp Thr Ala 
                325                 330                 335     


Met Leu Asn Asn Pro Lys Tyr 
            340             


<210>  11
<211>  435
<212>  PRT
<213>  Clostridium cavendishii

<400>  11

Met Gln Arg Asn Tyr Leu Leu Asp Ile Val Glu Ala Gln Asn Asn Gly 
1               5                   10                  15      


Ile His Lys Gly Ile Tyr Ser Ala Cys Ser Ala Asn Glu Tyr Val Ile 
            20                  25                  30          


Glu Ala Ala Met Glu Arg Ala Lys Asn Thr Asn Glu Tyr Val Leu Ile 
        35                  40                  45              


Glu Ala Thr Ala Asn Gln Val Asn Gln Tyr Gly Gly Tyr Thr Gly Met 
    50                  55                  60                  


Lys Pro Ile Asp Phe Lys Asn Phe Val Tyr Asp Ile Ala Asp Lys Ile 
65                  70                  75                  80  


Asn Phe Asp Lys Asp Lys Ile Ile Leu Gly Gly Asp His Leu Gly Pro 
                85                  90                  95      


Leu Thr Trp Ser Lys Glu Thr Glu Lys Glu Ala Met Ala Lys Ser His 
            100                 105                 110         


Glu Leu Val Lys Glu Tyr Val Met Ala Gly Phe Thr Lys Ile His Leu 
        115                 120                 125             


Asp Thr Ser Met Tyr Leu Ala Asp Asp Asp Arg Ser Lys Lys Leu Ala 
    130                 135                 140                 


Thr Glu Val Ile Ala Arg Arg Gly Ala Glu Leu Cys Lys Thr Ala Glu 
145                 150                 155                 160 


Glu Ser Phe Lys Ala Leu Lys Glu Arg Asn Ser Met Ala Val Ala Pro 
                165                 170                 175     


Val Tyr Ile Val Gly Ser Glu Val Pro Ile Pro Gly Gly Ile Gln Asp 
            180                 185                 190         


Glu Glu Glu Gly Ile Gln Val Thr Lys Pro Glu Asp Phe Leu Glu Thr 
        195                 200                 205             


Val Lys Val Tyr Lys Ala Glu Phe Lys Asp Lys Gly Ile Asp Glu Val 
    210                 215                 220                 


Trp Asn Arg Val Ile Gly Val Val Val Gln Pro Gly Val Glu Phe Gly 
225                 230                 235                 240 


Asp Glu Ser Val His Glu Tyr Asn Arg Glu Lys Ala Glu Lys Leu Val 
                245                 250                 255     


Asn Ser Leu Arg Gly Val Lys Gly Ile Val Phe Glu Gly His Ser Thr 
            260                 265                 270         


Asp Tyr Gln Thr Lys Thr Lys Leu Lys Glu Met Val Glu Asp Gly Ile 
        275                 280                 285             


Ala Ile Leu Lys Val Gly Pro Ala Leu Thr Tyr Gly Leu Arg Glu Ala 
    290                 295                 300                 


Leu Phe Ala Leu Asn His Ile Glu Asn Glu Ile Phe Lys Tyr Arg Ala 
305                 310                 315                 320 


Asp Ile Lys Leu Ser Asn Phe Ile Asn Val Leu Glu Thr Ser Met Val 
                325                 330                 335     


Glu Glu Pro Thr His Trp Lys Gln His Tyr His Gly Asp Ala Glu Asp 
            340                 345                 350         


Ile Lys Tyr Ala Met Arg Tyr Ser Tyr Ser Asp Arg Cys Arg Tyr Tyr 
        355                 360                 365             


Met Pro Thr Glu Ala Val Asn Lys Ala Met Asn Ile Leu Ile Glu Asn 
    370                 375                 380                 


Leu Glu Ser Val Glu Ile Pro Leu Thr Ile Ile Asp Gln Tyr Met Pro 
385                 390                 395                 400 


Met Gln Tyr Lys Lys Ile Arg Glu Gly Leu Ile Gln Asn Lys Pro Lys 
                405                 410                 415     


Glu Leu Ile Lys Asp Arg Ile Gly Asp Tyr Ile Asp Asp Tyr Leu Tyr 
            420                 425                 430         


Ala Leu Arg 
        435 


<210>  12
<211>  435
<212>  PRT
<213>  Kosmotoga olearia

<400>  12

Met Lys Lys His Pro Leu Gln Asp Ile Val Ser Leu Gln Lys Gln Gly 
1               5                   10                  15      


Ile Pro Lys Gly Val Phe Ser Val Cys Ser Ala Asn Arg Phe Val Ile 
            20                  25                  30          


Glu Thr Thr Leu Glu Tyr Ala Lys Met Lys Gly Thr Thr Val Leu Ile 
        35                  40                  45              


Glu Ala Thr Cys Asn Gln Val Asn Gln Phe Gly Gly Tyr Thr Gly Met 
    50                  55                  60                  


Thr Pro Ala Asp Phe Arg Glu Met Val Phe Ser Ile Ala Glu Asp Ile 
65                  70                  75                  80  


Gly Leu Pro Lys Asn Lys Ile Ile Leu Gly Gly Asp His Leu Gly Pro 
                85                  90                  95      


Asn Pro Trp Lys Gly Gln Pro Ser Asp Gln Ala Met Arg Asn Ala Ile 
            100                 105                 110         


Glu Met Ile Arg Glu Tyr Ala Lys Ala Gly Phe Thr Lys Leu His Leu 
        115                 120                 125             


Asp Ala Ser Met Arg Leu Ala Asp Asp Pro Gly Asn Glu Asn Glu Pro 
    130                 135                 140                 


Leu Asn Pro Glu Val Ile Ala Glu Arg Thr Ala Leu Leu Cys Leu Glu 
145                 150                 155                 160 


Ala Glu Arg Ala Phe Lys Glu Ser Ala Gly Ser Leu Arg Pro Val Tyr 
                165                 170                 175     


Val Ile Gly Thr Asp Val Pro Pro Pro Gly Gly Ala Gln Asn Glu Gly 
            180                 185                 190         


Lys Ser Ile His Val Thr Ser Val Gln Asp Phe Glu Arg Thr Val Glu 
        195                 200                 205             


Leu Thr Lys Lys Ala Phe Phe Asp His Gly Leu Tyr Glu Ala Trp Gly 
    210                 215                 220                 


Arg Val Ile Ala Val Val Val Gln Pro Gly Val Glu Phe Gly Asn Glu 
225                 230                 235                 240 


His Ile Phe Glu Tyr Asp Arg Asn Arg Ala Arg Glu Leu Thr Glu Ala 
                245                 250                 255     


Ile Lys Lys His Pro Asn Ile Val Phe Glu Gly His Ser Thr Asp Tyr 
            260                 265                 270         


Gln Thr Ala Lys Ala Leu Lys Glu Met Val Glu Asp Gly Val Ala Ile 
        275                 280                 285             


Leu Lys Val Gly Pro Ala Leu Thr Phe Ala Leu Arg Glu Ala Phe Phe 
    290                 295                 300                 


Ala Leu Ser Ser Ile Glu Lys Glu Leu Phe Tyr Asp Thr Pro Gly Leu 
305                 310                 315                 320 


Cys Ser Asn Phe Val Glu Val Val Glu Arg Ala Met Leu Asp Asn Pro 
                325                 330                 335     


Lys His Trp Glu Lys Tyr Tyr Gln Gly Glu Glu Arg Glu Asn Arg Leu 
            340                 345                 350         


Ala Arg Lys Tyr Ser Phe Leu Asp Arg Leu Arg Tyr Tyr Trp Asn Leu 
        355                 360                 365             


Pro Glu Val Arg Thr Ala Val Asn Lys Leu Ile Thr Asn Leu Glu Thr 
    370                 375                 380                 


Lys Glu Ile Pro Leu Thr Leu Ile Ser Gln Phe Met Pro Met Gln Tyr 
385                 390                 395                 400 


Gln Lys Ile Arg Asn Gly Leu Leu Arg Lys Asp Pro Ile Ser Leu Ile 
                405                 410                 415     


Lys Asp Arg Ile Thr Leu Val Leu Asp Asp Tyr Tyr Phe Ala Thr His 
            420                 425                 430         


Pro Glu Cys 
        435 


<210>  13
<211>  440
<212>  PRT
<213>  Butyricicoccus pullicaecorum

<400>  13

Met Asn His Asn Pro Leu Lys Lys Ile Val Glu Leu Gln Lys Gln Gly 
1               5                   10                  15      


Lys Asn Val Gly Ile Tyr Ser Val Cys Ser Ala Asn Gly Tyr Val Ile 
            20                  25                  30          


Glu Ala Ala Leu Lys Arg Gly Lys Ser Asp Gly Ser Cys Val Leu Ile 
        35                  40                  45              


Glu Ser Thr Ala Asn Gln Cys Asp Gln Asn Gly Gly Tyr Thr Gly Met 
    50                  55                  60                  


Thr Pro Leu Asp Phe Lys Asn Phe Val Leu Gly Ile Ala Asp Lys Val 
65                  70                  75                  80  


Gly Phe Asp Pro Lys Arg Leu Phe Leu Gly Gly Asp His Leu Gly Pro 
                85                  90                  95      


Leu Thr Phe Ala Gly Met Asp Glu Ala Gln Ala Met Glu Asn Ala Glu 
            100                 105                 110         


Glu Leu Ile Arg His Tyr Val Gly Ala Gly Phe Thr Lys Ile His Ile 
        115                 120                 125             


Asp Thr Ser Met Lys Val Ala Ser Asp Asp Pro Asn Thr Arg Leu Ser 
    130                 135                 140                 


Asp Glu Thr Ile Ala Lys Arg Gly Ala Arg Leu Ala Arg Val Ala Gln 
145                 150                 155                 160 


Asp Thr Tyr His Lys Leu Leu Glu Ser Asp Pro Asp Ala Ile Ala Pro 
                165                 170                 175     


Val Tyr Ile Val Gly Ser Glu Val Pro Ile Pro Gly Gly Ala Val Gly 
            180                 185                 190         


Ala Val Asp Gln Gly Val Gln Val Thr Lys Val Glu Asp Phe Lys Asn 
        195                 200                 205             


Thr Val Ala Thr Phe Glu Lys Ala Phe Arg Glu Gln Gly Leu Asp Glu 
    210                 215                 220                 


Ala Trp Asp Asn Val Ile Gly Val Val Val Gln Pro Gly Val Glu Glu 
225                 230                 235                 240 


Lys Asp Ser Gly Cys Thr Glu Tyr Asp Arg Glu Lys Ala Lys Asp Leu 
                245                 250                 255     


Met Ala Ser Ile Gln Glu Phe Pro Asn Leu Val Phe Glu Gly His Ser 
            260                 265                 270         


Thr Asp Tyr Gln Thr Lys Ile Lys Leu Arg Glu Leu Val Glu Asp Gly 
        275                 280                 285             


Val Gly Ile Leu Lys Val Gly Pro Ala Leu Thr Phe Ala Met Arg Glu 
    290                 295                 300                 


Gly Met Phe Ala Leu Glu Asn Ile Glu Lys Glu Leu Ile Tyr Gly Thr 
305                 310                 315                 320 


Asp Ile Thr Pro Ser Gly Phe Gln Asp Ala Leu Glu Ala Glu Met Leu 
                325                 330                 335     


Lys Glu Gly Lys His Trp Arg Lys His Tyr Gln Gly Thr Glu Leu Glu 
            340                 345                 350         


Leu Arg Met Lys Arg Lys Tyr Ser Phe Ser Asp Arg Cys Arg Tyr Tyr 
        355                 360                 365             


Met Pro Thr Pro Ala Val Glu Ala Ala Lys Glu Arg Leu Ile Ser Asn 
    370                 375                 380                 


Leu Arg Thr Leu Gly Ile Pro Leu Asn Leu Leu Ser Gln Phe Met Pro 
385                 390                 395                 400 


Ile Gln Tyr Thr Lys Val Arg Glu Gly Leu Leu Val Asn Asp Pro Val 
                405                 410                 415     


Glu Leu Val Glu Asp Arg Ile Ile Asn Thr Ile Asp Glu Tyr Leu Tyr 
            420                 425                 430         


Ala Thr His Gln Lys Glu Leu Leu 
        435                 440 


<210>  14
<211>  447
<212>  PRT
<213>  Clostridium thermobutyricum

<400>  14

Met Leu Leu Lys Val Lys Glu His Pro Ile Arg Glu Leu Val Asn Arg 
1               5                   10                  15      


Tyr Lys Asn Gly Glu Asn Val Gly Ile Phe Ser Val Cys Thr Ser Asn 
            20                  25                  30          


Glu Tyr Val Ile Glu Ala Ala Met Glu Arg Val Ile Asp Lys Asp Leu 
        35                  40                  45              


Asp Leu Leu Ile Glu Ser Thr Ala Asn Gln Val Asn Gln Asp Gly Gly 
    50                  55                  60                  


Tyr Thr Gly Met Gln Pro Lys Asp Phe Val Asn Tyr Val Tyr Lys Ile 
65                  70                  75                  80  


Ala Asp Lys Val Asn Phe Pro Lys Asp Arg Ile Ile Leu Gly Gly Asp 
                85                  90                  95      


His Leu Gly Pro Leu Thr Trp Thr Lys Leu Val Gln Glu Glu Ala Met 
            100                 105                 110         


Glu Lys Ala Lys Val Leu Ile Arg Asp Tyr Val Leu Ala Gly Phe Thr 
        115                 120                 125             


Lys Ile His Ile Asp Thr Ser Met Pro Ile Tyr Asp Asp Leu Glu Lys 
    130                 135                 140                 


Gly Val Phe Gly Asp Asp Leu Ile Ala Glu Arg Ala Ala Ile Leu Cys 
145                 150                 155                 160 


Asn Val Ala Glu Ile Ala Tyr Arg Glu Leu Leu Lys Thr Asn Glu Asp 
                165                 170                 175     


Ala Ile His Pro Ile Tyr Val Val Gly Ser Glu Val Pro Val Pro Gly 
            180                 185                 190         


Gly Val Gln Ala Glu Glu Ala Glu Glu Glu Ile Glu Asn Gly Ile Lys 
        195                 200                 205             


Val Thr Arg Val Glu Asp Phe Lys Asn Thr Val Glu Val Phe Lys Lys 
    210                 215                 220                 


Lys Phe Lys Glu His Gly Val Glu Glu Ala Phe Asn Tyr Val Val Gly 
225                 230                 235                 240 


Val Val Val Gln Pro Gly Val Glu Phe Ser Ser Asp Thr Val Trp Lys 
                245                 250                 255     


Tyr Glu Arg Glu Lys Ala Lys Asp Leu Ser Lys Ala Leu Lys Glu Tyr 
            260                 265                 270         


Asp Asn Leu Val Phe Glu Ala His Ser Thr Asp Tyr Gln Ser Pro Lys 
        275                 280                 285             


Ser Leu Arg Glu Met Val Leu Asp Gly Phe Asn Ile Leu Lys Val Gly 
    290                 295                 300                 


Pro Ala Leu Thr Phe Gly Phe Arg Glu Ala Ala Phe Ala Leu Asn Lys 
305                 310                 315                 320 


Ile Glu Glu Glu Met Phe Arg Phe Arg Pro Asp Ile Glu Glu Ser Arg 
                325                 330                 335     


Phe Ile Gln Thr Leu Asp Tyr Asn Met Val Lys His Pro Glu Asn Trp 
            340                 345                 350         


Ile Lys His Tyr Ser Gly Thr Ser Glu Asn Ile Arg Phe Ser Arg Met 
        355                 360                 365             


Tyr Ser Leu Ser Asp Arg Cys Arg Tyr Tyr Met Pro Asn Glu Glu Val 
    370                 375                 380                 


Glu Tyr Ser Phe Asn Lys Met Ile Asn Asn Leu Asp Lys Glu Glu Ile 
385                 390                 395                 400 


Pro Ile Ala Leu Ile Ser Gln Tyr Met His Asn Gln Tyr Lys Lys Val 
                405                 410                 415     


Arg Asp Gly Glu Leu Lys Pro Lys Gly Leu Asn Leu Leu Lys Asp Phe 
            420                 425                 430         


Ile Gly Glu Tyr Val Asp Asp Tyr Ile Phe Ala Val Glu Asp Lys 
        435                 440                 445         


<210>  15
<211>  431
<212>  PRT
<213>  Litorilinea aerophila

<400>  15

Met Tyr Pro Val Leu Glu Asn Ile Leu Arg Ala Gln Gln Gln Gly Glu 
1               5                   10                  15      


Ala Leu Gly Ile Pro Ser Ile Cys Ser Ala His Pro Phe Val Leu Glu 
            20                  25                  30          


Ala Thr Phe Arg His Ala Leu Thr Thr Gly Arg Thr Val Leu Ile Glu 
        35                  40                  45              


Ser Thr Cys Asn Gln Val Asn Gln His Gly Gly Tyr Thr Gly Met Thr 
    50                  55                  60                  


Pro Gly Asp Phe Val Ala Tyr Val Ala Ala Leu Ala Asp Arg Leu His 
65                  70                  75                  80  


Phe Pro Arg Glu Arg Ile Leu Leu Gly Gly Asp His Leu Gly Pro Asn 
                85                  90                  95      


Pro Trp Arg Asp Arg Pro Ala Asp Gln Ala Leu Asn Gln Ala Arg Ile 
            100                 105                 110         


Leu Val Gln Glu Tyr Val Arg Ala Gly Tyr Gly Lys Ile His Leu Asp 
        115                 120                 125             


Ala Ser Met Ala Cys Gly Gly Asp Pro Ala Asp Ala Pro Leu Asp Lys 
    130                 135                 140                 


Ala Val Ala Ala Glu Arg Ala Ala Ala Leu Ala Glu Ala Ala Glu Ala 
145                 150                 155                 160 


Ala Phe Gln Arg Met Gly Ser Gly Thr Pro Pro Cys Tyr Val Ile Gly 
                165                 170                 175     


Thr Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Asp Asp Met Pro Leu 
            180                 185                 190         


Ala Ile Thr Ala Pro Arg Glu Val Ala Glu Thr Ile Glu Leu Thr Gln 
        195                 200                 205             


Ala Ala Phe Arg Arg Arg Gly Leu Glu Ala Ala Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Val Val Val Gln Pro Gly Val Glu Phe Gly Asp Glu Gln Val His 
225                 230                 235                 240 


Pro Tyr Asp Arg Ala Ala Ala Ala Gly Leu Ala Arg Ala Ile Glu Pro 
                245                 250                 255     


Tyr Gly Arg Leu Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Gln Ala Leu Arg Asp Leu Val Ala Asp His Phe Ala Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Phe Arg Glu Ala Val Phe Ala Leu Ala 
    290                 295                 300                 


Ala Val Glu Glu Glu Trp Leu Ala Gly Gln Ala Gly Val Val Leu Ser 
305                 310                 315                 320 


Arg Leu Arg Glu Glu Leu Glu Ala Ala Met Ile Gln Asp Pro Thr His 
                325                 330                 335     


Trp Arg Gly Tyr Tyr Arg Gly Asp Glu Arg His Gln Arg Leu Ala Arg 
            340                 345                 350         


Arg Tyr Ser Tyr Ser Asp Arg Ala Arg Tyr Tyr Trp Pro Arg Pro Ser 
        355                 360                 365             


Val Gln Ala Ala Leu Glu Arg Leu Leu His Asn Leu Glu Ala Ala Pro 
    370                 375                 380                 


Pro Pro Leu Thr Leu Leu Ser Gln Tyr Leu Pro Val Gln Tyr Trp Ser 
385                 390                 395                 400 


Val Arg Glu Gly Leu Leu Glu Pro Thr Pro Arg Ser Leu Ile Val Asp 
                405                 410                 415     


Lys Ile Ile Gln Val Leu Asn Asp Tyr Thr Trp Ala Cys Gly Gly 
            420                 425                 430     


<210>  16
<211>  435
<212>  PRT
<213>  Enterobacter mori.

<400>  16

Met Glu Arg Lys Val Lys His Leu Thr His Met Val Glu Gln His Lys 
1               5                   10                  15      


Arg Gly Asn Ala Asn Gly Ile Tyr Ala Val Cys Ser Ala His Pro Leu 
            20                  25                  30          


Val Leu Glu Ala Ala Ile Arg Tyr Ala Gln Ser His Gln Thr Pro Leu 
        35                  40                  45              


Leu Ile Glu Ala Thr Ser Asn Gln Val Asp Gln Phe Gly Gly Tyr Thr 
    50                  55                  60                  


Gly Met Thr Pro Glu Asp Phe Tyr Gly Phe Val Cys Cys Leu Ala Glu 
65                  70                  75                  80  


Ser Leu Asp Phe Pro Thr Ser Gln Leu Ile Leu Gly Gly Asp His Leu 
                85                  90                  95      


Gly Pro Asn Arg Trp Gln Asn Leu Pro Ala Gln Gln Ala Met Ala Asn 
            100                 105                 110         


Ala Asp Asp Leu Ile Lys Ser Tyr Val Ala Ala Gly Phe Lys Lys Ile 
        115                 120                 125             


His Leu Asp Cys Ser Met Ser Cys Glu Asp Asp Pro Val Pro Leu Thr 
    130                 135                 140                 


Asp Ala Ile Val Ala Glu Arg Ala Ala Arg Leu Ala Lys Ile Ala Glu 
145                 150                 155                 160 


Ala Thr Cys Arg Glu Gln Phe Gly Val Thr Asp Leu Val Tyr Val Ile 
                165                 170                 175     


Gly Thr Glu Val Pro Val Pro Gly Gly Ala His Glu Thr Leu Thr Glu 
            180                 185                 190         


Leu Glu Val Thr Thr Pro Asp Ala Ala Arg Ala Thr Leu Glu Ala His 
        195                 200                 205             


Arg His Ala Leu Glu Lys Glu Gly Leu Asn Asp Ile Trp Pro Arg Ile 
    210                 215                 220                 


Ile Gly Leu Val Val Gln Pro Gly Val Glu Phe Asp His Ala His Val 
225                 230                 235                 240 


Cys Asp Tyr Gln Pro His Lys Ala Val Ala Leu Ser Lys Met Val Glu 
                245                 250                 255     


Ala Tyr Asp Thr Leu Leu Phe Glu Ala His Ser Thr Asp Tyr Gln Thr 
            260                 265                 270         


Pro Gln Ala Leu Arg Gln Leu Val Lys Asp His Phe Ala Ile Leu Lys 
        275                 280                 285             


Val Gly Pro Ala Leu Thr Phe Ala Leu Arg Glu Ala Leu Phe Ser Leu 
    290                 295                 300                 


Ala Ala Ile Glu Glu Glu Leu Leu Pro Ala Lys Ala Ser Ser Gly Leu 
305                 310                 315                 320 


Arg His Val Leu Glu Asn Val Met Leu Asp Arg Pro Glu Tyr Trp Gln 
                325                 330                 335     


Ser His Tyr His Gly Asp Gly Asn Ala Arg Arg Leu Ala Arg Gly Tyr 
            340                 345                 350         


Ser Tyr Ser Asp Arg Val Arg Tyr Tyr Trp Pro Asp Ser Gln Ile Asp 
        355                 360                 365             


Asp Ala Phe Glu Arg Leu Val Arg Asn Leu Ala Asp Glu Pro Ile Pro 
    370                 375                 380                 


Leu Pro Leu Ile Ser Gln Tyr Leu Pro Leu Gln Tyr Gly Lys Val Arg 
385                 390                 395                 400 


Glu Gly Ala Leu Lys Ser Thr Pro Arg Glu Leu Ile Ile Asp His Ile 
                405                 410                 415     


Gln Asp Ile Leu Gln Gln Tyr His Ala Ala Cys Glu Gly Val Thr Thr 
            420                 425                 430         


Gln Asn Ala 
        435 


<210>  17
<211>  415
<212>  PRT
<213>  Caldisericum exile

<400>  17

Met Trp Leu Asp Ser Asn Phe Leu Lys Asn Arg Gly Ile Phe Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Asn Val Leu Asp Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Glu Asp Phe Leu Leu Ile Glu Ala Thr Cys His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Lys Met Thr Pro Glu Ser Phe Ser Lys Lys 
    50                  55                  60                  


Ile Phe Lys Lys Ala Glu Glu Met Asn Phe Asn Pro Glu Arg Leu Leu 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Glu Pro Trp Lys Asn Glu Asn Ala 
                85                  90                  95      


Asp Thr Ala Met Asp Lys Ala Lys Gln Leu Val Ile Glu Phe Val Lys 
            100                 105                 110         


Asn Gly Phe Asn Lys Ile His Leu Asp Cys Ser Met Pro Leu Lys Gly 
        115                 120                 125             


Asp Ser Asp Phe Ser Thr Thr Leu Val Ala Asp Arg Glu Ala Glu Leu 
    130                 135                 140                 


Cys Ala Val Ala Glu Glu Thr Tyr Glu Lys Tyr Gly Gly Asn Arg Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Glu Val Pro Ala Pro Gly Gly Ser Thr Asn 
                165                 170                 175     


Glu Val Pro Glu Val Thr Ser Ile Glu Glu Leu Asp Glu Met Ile Glu 
            180                 185                 190         


Glu Leu Gln Asn Ala Phe Leu Arg Leu Gly Leu Lys Asn Ala Trp Asp 
        195                 200                 205             


Arg Val Ile Ala Ile Val Val Arg Leu Gly Ile Gly Phe Gly Gly Asp 
    210                 215                 220                 


Ser Val Ser Glu Tyr Glu Ser Glu Lys Thr Lys Glu Leu Cys Thr Tyr 
225                 230                 235                 240 


Leu Ser Arg Tyr Tyr Pro Ser Leu Tyr Phe Glu Ala His Ser Thr Asp 
                245                 250                 255     


Tyr Gln Thr Ala Gly Ser Leu Lys Gln Met Val Lys Asp Gly Ile Arg 
            260                 265                 270         


Ile Leu Lys Val Gly Pro Ala Leu Thr Asp Ala Tyr Arg Arg Gly Met 
        275                 280                 285             


Phe Ala Leu Asn Phe Ile Glu Lys Glu Ser Ile Asp Glu Glu Lys Gln 
    290                 295                 300                 


Ser Arg Leu Val Glu Asn Val Leu Lys Val Met Asp Glu Tyr Pro Arg 
305                 310                 315                 320 


Tyr Trp Glu Asp Tyr Tyr Asn Ser Val Gly Lys Thr Leu Arg Leu Asp 
                325                 330                 335     


Gln Met Tyr Ser Tyr Phe Asp Arg Ile Arg Tyr Tyr Trp Gly Phe Glu 
            340                 345                 350         


Glu Val Glu Lys Ser Lys Asn Arg Leu Ile Glu Asn Leu Lys Asp Met 
        355                 360                 365             


Gln Met Asn Leu Ile Arg Gln Tyr Leu Pro Glu Gln Tyr Glu Lys Ile 
    370                 375                 380                 


Arg Glu Asn Lys Leu Asn Lys Asp Pro Arg Ala Leu Ile Asn Tyr Glu 
385                 390                 395                 400 


Ile Lys Lys Val Leu Asn Asp Tyr Gln Lys Ser Val Ile Leu Glu 
                405                 410                 415 


<210>  18
<211>  408
<212>  PRT
<213>  Dictyoglomus thermophilum

<400>  18

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Val Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Asn Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Ile Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Gly Ile Ile Lys Glu Lys Gly Ile Glu Glu Asp Arg Val Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Ser Ser Ala Met Lys Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Leu Asp Cys Ser Met Ser Leu Ser Asp 
        115                 120                 125             


Asp Pro Val Val Leu Ser Pro Glu Lys Ile Ala Glu Arg Glu Arg Glu 
    130                 135                 140                 


Leu Leu Glu Val Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Val Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Val Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Glu Asp Val Pro Arg Ile Trp Asp Arg Ile Ile Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Asn Tyr Glu Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ile Lys Val Arg Lys Ile Leu Glu Glu Val Lys Lys Glu 
225                 230                 235                 240 


Asn Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Thr Lys Arg Ala 
                245                 250                 255     


Leu Arg Asp Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ser Phe Arg Arg Gly Val Phe Leu Leu Ser Ser Ile 
        275                 280                 285             


Glu Asp Glu Leu Ile Ser Glu Asp Lys Arg Ser Asn Ile Lys Lys Val 
    290                 295                 300                 


Val Leu Glu Thr Met Leu Lys Asp Asp Lys Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Lys Glu Ile Lys Ile Ala Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Tyr Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Lys Val Arg Glu Gly Lys Ile Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Asn Glu Ile Lys Lys Val Leu Glu 
385                 390                 395                 400 


Asp Tyr His Tyr Ala Val Asn Leu 
                405             


<210>  19
<211>  420
<212>  PRT
<213>  Rhodothermus marinus

<400>  19

Met Gln Ala Gln Ala Leu Leu Thr Val Pro Phe Asp Arg Val Ala Thr 
1               5                   10                  15      


His Ala Arg Gly Phe Val Gly Trp Val Ala Glu Leu Leu Leu Gly Pro 
            20                  25                  30          


Leu Ala His Gln His Thr Leu Leu Ala Val Cys Pro Asn Ser Glu Ala 
        35                  40                  45              


Val Thr Arg Ala Ala Leu Glu Ala Ala Ala Glu Val Asn Ala Pro Leu 
    50                  55                  60                  


Leu Phe Ala Ala Thr Leu Asn Gln Val Asp Leu Asp Gly Gly Tyr Thr 
65                  70                  75                  80  


Gly Trp Thr Pro Ala Thr Leu Ala Arg Phe Val Ala Asp Glu Leu Ala 
                85                  90                  95      


Arg Leu Asp Leu His Ile Pro Val Val Leu Gly Leu Asp His Gly Gly 
            100                 105                 110         


Pro Trp Lys Lys Asp Leu His Ala Arg Asn Arg Leu Ser Phe Ala Glu 
        115                 120                 125             


Thr Val Gln Ala Val Leu Arg Ala Ile Glu Ala Cys Leu Asp Ala Gly 
    130                 135                 140                 


Tyr Gly Leu Leu His Leu Asp Pro Thr Val Asp Leu Glu Leu Pro Pro 
145                 150                 155                 160 


Gly Thr Pro Val Pro Ile Pro Arg Ile Val Glu Arg Thr Val Ala Leu 
                165                 170                 175     


Leu Arg His Ala Glu Thr Tyr Arg Leu Arg Arg Asn Leu Pro Pro Val 
            180                 185                 190         


Ala Tyr Glu Val Gly Thr Glu Glu Val Gly Gly Gly Leu Gln Ala Glu 
        195                 200                 205             


Ala Arg Met Ala Glu Phe Leu Asp Arg Leu Trp Thr Ala Leu Asp Arg 
    210                 215                 220                 


Glu Gly Leu Pro His Pro Ile Phe Val Val Gly Asp Ile Gly Thr Arg 
225                 230                 235                 240 


Leu Asp Thr Arg Thr Phe Asp Phe Glu Arg Ala Cys Arg Leu Asp Ala 
                245                 250                 255     


Leu Val Arg Arg Tyr Gly Ala Leu Ile Lys Gly His Tyr Thr Asp Asp 
            260                 265                 270         


Val Asp Arg Leu Asp Leu Tyr Pro Lys Ala Gly Ile Gly Gly Ala Asn 
        275                 280                 285             


Val Gly Pro Gly Leu Ala Ala Ile Glu Phe Glu Ala Leu Glu Val Leu 
    290                 295                 300                 


Val Asp Glu Ala Arg Arg Arg Gly Leu Ser Val Thr Phe Asp Gln Ala 
305                 310                 315                 320 


Ile Arg Arg Ala Val Val Glu Ser Gly Arg Trp Thr Lys Trp Leu Gln 
                325                 330                 335     


Pro Glu Glu Lys Gly Arg Pro Phe Glu Ala Leu Asp Pro Glu Arg Gln 
            340                 345                 350         


Arg Trp Leu Val Ala Thr Gly Ser Arg Tyr Val Trp Thr His Pro Ala 
        355                 360                 365             


Val Leu Gln Ala Arg Arg Glu Leu Tyr Glu Ala Leu Ala Pro Trp Leu 
    370                 375                 380                 


Asp Ala Asp Ala Phe Val Arg Glu Arg Ile Lys Ala Arg Leu Met Asp 
385                 390                 395                 400 


Tyr Phe Arg Ala Phe Asn Leu Ile His Phe Asn Glu Arg Leu Gln Ala 
                405                 410                 415     


Phe Leu Pro Glu 
            420 


<210>  20
<211>  420
<212>  PRT
<213>  Rhodothermus profundi

<400>  20

Met Gln Ala His Val Leu Leu Ala Pro Ser Phe Glu Gln Leu Ala Asp 
1               5                   10                  15      


His Arg His Gly Phe Val Gly Trp Leu Val Asp Leu Leu Arg Gly Pro 
            20                  25                  30          


Leu Ala Tyr Arg His Thr Leu Leu Ala Val Cys Pro Asn Ser Glu Ala 
        35                  40                  45              


Val Thr Arg Ala Ala Leu Glu Ala Ala Arg Glu Ala Asn Ala Pro Leu 
    50                  55                  60                  


Phe Phe Ala Ala Thr Leu Asn Gln Val Asp Leu Asp Gly Gly Tyr Thr 
65                  70                  75                  80  


Gly Trp Thr Pro Ala Thr Leu Ala Arg Phe Val Ala Asp Glu Arg Ile 
                85                  90                  95      


Arg Leu Gly Leu Arg Ala Pro Val Val Leu Gly Leu Asp His Gly Gly 
            100                 105                 110         


Pro Trp Lys Lys Asp Trp His Val Arg Asn Arg Leu Pro Tyr Glu Ala 
        115                 120                 125             


Thr Leu Gln Ala Val Leu Arg Ala Ile Glu Ala Cys Leu Asp Ala Gly 
    130                 135                 140                 


Tyr Gly Leu Leu His Leu Asp Pro Thr Val Asp Leu Glu Leu Pro Pro 
145                 150                 155                 160 


Gly Thr Pro Val Pro Ile Pro Arg Ile Val Glu Arg Thr Val Ala Leu 
                165                 170                 175     


Leu Gln His Ala Glu Thr Tyr Arg Gln Gln Arg Arg Leu Pro Pro Val 
            180                 185                 190         


Ala Tyr Glu Val Gly Thr Glu Glu Val Gly Gly Gly Leu Gln Ala Glu 
        195                 200                 205             


Ala Arg Met Ala Glu Phe Leu Asp Arg Leu Trp Thr Val Leu Asp Arg 
    210                 215                 220                 


Glu Gly Leu Pro Arg Pro Val Phe Val Val Gly Asp Ile Gly Thr Arg 
225                 230                 235                 240 


Leu Asp Thr His Thr Phe Asp Phe Glu Arg Ala Arg Arg Leu Asp Ala 
                245                 250                 255     


Leu Val Arg Arg Tyr Gly Ala Leu Ile Lys Gly His Tyr Thr Asp Gly 
            260                 265                 270         


Val Asp Arg Leu Asp Leu Tyr Pro Gln Ala Gly Ile Gly Gly Ala Asn 
        275                 280                 285             


Val Gly Pro Gly Leu Ala Ala Ile Glu Phe Glu Ala Leu Glu Ala Leu 
    290                 295                 300                 


Val Ala Glu Ala His Arg Arg Lys Leu Pro Val Thr Phe Asp Arg Thr 
305                 310                 315                 320 


Ile Arg Gln Ala Val Ile Glu Ser Gly Arg Trp Gln Lys Trp Leu Arg 
                325                 330                 335     


Pro Glu Glu Lys Gly Arg Pro Phe Glu Ala Leu Pro Pro Glu Arg Gln 
            340                 345                 350         


Arg Trp Leu Val Ala Thr Gly Ser Arg Tyr Val Trp Thr His Pro Ala 
        355                 360                 365             


Val Arg Gln Ala Arg His Gln Leu Tyr Gln Val Leu Ala Pro Trp Leu 
    370                 375                 380                 


Asp Ala Asp Ala Phe Val Arg Ala Arg Ile Lys Ala Arg Leu Met Asp 
385                 390                 395                 400 


Tyr Phe Arg Ala Phe Asn Leu Ile Gly Phe Asn Glu Arg Leu Gln Ala 
                405                 410                 415     


Phe Leu Pro Asn 
            420 


<210>  21
<211>  428
<212>  PRT
<213>  Caldibacillus debilis.

<400>  21

Met Ala Lys Ile Pro Ile Gln Ser Ala Val Lys Ala Leu Leu Glu Leu 
1               5                   10                  15      


Gln Asp Glu Gly Lys Gly Gly Thr Leu Leu Gly Ile Gly Pro Met Ser 
            20                  25                  30          


Thr Asn Val Leu Gln Ala Ser Phe Glu Leu Ala Arg Asp Tyr Asp Phe 
        35                  40                  45              


Pro Leu Met Phe Ile Ala Ser Arg Asn Gln Val Asp Leu Asp Glu Leu 
    50                  55                  60                  


Gly Gly Gly Tyr Val Asn Gly Trp Asn Gln Tyr Thr Phe Val Gln Ala 
65                  70                  75                  80  


Ile Arg Glu Met Ala Glu Leu Thr Gly Phe Asp Gly Leu Tyr Tyr Val 
                85                  90                  95      


Cys Arg Asp His Gly Gly Pro Trp Gln Arg Asp Lys Glu Arg Asn Asp 
            100                 105                 110         


His Leu Pro Val Glu Glu Ala Met Ala Leu Gly Lys Lys Ser Tyr Leu 
        115                 120                 125             


Ala Asp Ile Glu Ala Gly Phe Asp Leu Leu Met Ile Asp Pro Thr Lys 
    130                 135                 140                 


Asp Pro Phe Glu Ile Gly Lys Val Ile Pro Leu Glu Lys Val Ile Glu 
145                 150                 155                 160 


Arg Thr Val Glu Leu Ile Glu Phe Cys Glu Lys Glu Arg Gln Ala Arg 
                165                 170                 175     


Asp Leu Pro Glu Ile Gly Tyr Glu Val Gly Thr Glu Glu Thr Asn Gly 
            180                 185                 190         


Gly Leu Thr Ser Thr Glu Thr Tyr Glu Thr Phe Ile Leu Arg Leu Gln 
        195                 200                 205             


Glu Glu Leu Gly Arg Arg Asp Leu Pro Met Pro Thr Phe Ile Val Gly 
    210                 215                 220                 


Gln Thr Gly Thr Leu Val Arg Lys Thr Glu Gln Ala Gly Arg Phe Ser 
225                 230                 235                 240 


Phe Glu Asn Ala Ala Asp Leu Ala Lys Met Ala Lys Lys Tyr Gly Val 
                245                 250                 255     


Gly Leu Lys Glu His Asn Gly Asp Tyr Leu Asp Asp Val Ile Leu Leu 
            260                 265                 270         


Ala His Ile Pro Ser Gln Ile Thr Ala Thr Asn Val Ala Pro Gln Tyr 
        275                 280                 285             


Gly Thr Glu Glu Thr Arg Ala Leu Leu Lys Leu Ala Lys Leu Glu Glu 
    290                 295                 300                 


Lys Leu Lys Glu Gln Gly Leu Ile Gly Gln Pro Ser Lys Val Lys Asp 
305                 310                 315                 320 


Val Leu Leu Tyr His Ser Ile Lys Ser Glu Arg Trp Arg Lys Trp Met 
                325                 330                 335     


Val Gly Ser Gln Arg Glu Leu Ser Val Glu Glu Ile Val Lys Asp Glu 
            340                 345                 350         


Glu Leu Ser Thr Glu Ile Leu Asp Ile Ala Gly His Tyr Thr Phe Asn 
        355                 360                 365             


Ile Asp Glu Val Lys Glu Glu Ile Asn Lys Leu Tyr Arg Asn Leu Ser 
    370                 375                 380                 


Lys Ala His Ile Asp Gly Gln Arg Phe Val Val Asp His Ile Lys Arg 
385                 390                 395                 400 


Ser Ile Arg Asn Tyr Val Glu Cys Phe Asn Leu Lys Gly Leu Thr Ser 
                405                 410                 415     


Arg Ile Lys Glu Lys Leu Asn Gly Ser Lys Asn Ala 
            420                 425             


<210>  22
<211>  421
<212>  PRT
<213>  Caloramator quimbayensis

<400>  22

Met Lys Lys Ile Ser Ile Phe Glu Ile Val Lys Ala Ser Leu Asn Met 
1               5                   10                  15      


Lys Gly Lys Asp Lys Ala Thr Leu Leu Gly Ile Gly Pro Met Ser Lys 
            20                  25                  30          


Thr Leu Ile Lys Ala Ser Met Ile Leu Ala Lys Glu Lys Asp Phe Pro 
        35                  40                  45              


Leu Met Phe Ile Ala Ser Arg Asn Gln Val Asp Leu Lys Glu Leu Gly 
    50                  55                  60                  


Gly Gly Tyr Val Cys Asn Trp Asp Gln Lys Ser Phe Ala Ser Asp Ile 
65                  70                  75                  80  


Lys Lys Ile Ala Glu Glu Val Gly Phe Asn Gly Leu Tyr Phe Leu Cys 
                85                  90                  95      


Arg Asp His Gly Gly Pro Trp Gln Arg Asp Asn Glu Arg Asn Ala His 
            100                 105                 110         


Leu Pro Glu Asn Glu Ala Met Glu Leu Gly Lys Lys Ser Tyr Leu Glu 
        115                 120                 125             


Asp Leu Ile Asn Gly Phe Asp Leu Leu His Ile Asp Pro Thr Lys Asp 
    130                 135                 140                 


Pro Tyr Ile Val Gly Lys Thr Val Pro Met Glu Ile Val Leu Lys Arg 
145                 150                 155                 160 


Thr Ile Glu Leu Ile Glu Tyr Val Glu Arg Glu Arg Lys Glu Arg Asn 
                165                 170                 175     


Leu Pro Pro Ile Ser Tyr Glu Val Gly Thr Glu Glu Thr Asn Gly Gly 
            180                 185                 190         


Leu Thr Ser Glu Glu Ala Tyr Glu Thr Phe Ile Lys Thr Leu Ile Glu 
        195                 200                 205             


Glu Leu Asp Lys Arg Asn Leu Pro Lys Pro Ser Phe Ile Val Gly Gln 
    210                 215                 220                 


Thr Gly Thr Leu Thr Arg Leu Thr Glu Asn Val Gly Asn Phe Asn Thr 
225                 230                 235                 240 


Lys Asn Ser Lys Lys Leu Ala Asp Ile Ala Lys Lys Tyr Ser Val Gly 
                245                 250                 255     


Leu Lys Glu His Asn Gly Asp Tyr Leu Asp Glu Ala Ile Leu Leu Glu 
            260                 265                 270         


His Pro Ala Leu Gly Ile Thr Ala Met Asn Val Ala Pro Glu Phe Gly 
        275                 280                 285             


Ser Val Glu Thr Gln Ala Tyr Leu Lys Leu Ile Glu Val Glu Asn Asn 
    290                 295                 300                 


Leu Tyr Glu His Gly Ile Ile Ser Lys Lys Ser Asn Leu Glu Lys Val 
305                 310                 315                 320 


Ile Lys Glu Glu Ala Val Lys Ser Leu Arg Trp Lys Lys Trp Met Val 
                325                 330                 335     


Gly Asp Lys Val Asn Leu Ser Ile Glu Glu Val Leu Ser Asp Lys Asp 
            340                 345                 350         


Leu Thr Asp Leu Ile Thr Glu Ile Ser Gly His Tyr Thr Phe Asn Asn 
        355                 360                 365             


Glu Arg Val Lys Cys Glu Ile Gln Leu Met Phe Asp Asn Leu Asn Lys 
    370                 375                 380                 


Ala Gly Val Asp Gly Glu Lys Tyr Val Ile Asn Lys Ile Lys Asp Ser 
385                 390                 395                 400 


Ile Asp Lys Tyr Ile Lys Tyr Phe Asn Leu Glu Gly Phe Thr Thr Lys 
                405                 410                 415     


Val Leu Ser Asn Val 
            420     


<210>  23
<211>  378
<212>  PRT
<213>  Methanosalsum zhilinae

<400>  23

Met Thr Asp Thr Asn Tyr Lys Ala Lys Pro Gly Ser Leu Leu Phe Glu 
1               5                   10                  15      


Ser Leu Met Asp Lys Glu Thr Ile Ile Leu Ala Ile Asn Pro Arg Ile 
            20                  25                  30          


Ser Leu Leu Asn Lys Gly Ile Leu Lys Ala Ala Lys Asp Met Asp Ala 
        35                  40                  45              


Pro Ile Ile Leu Glu Leu Ala Lys Ser Glu Cys Asn Leu Glu Gly Gly 
    50                  55                  60                  


Tyr Thr Gly Phe Thr Pro Ser Glu Phe Ser Lys Arg Ala Tyr Glu Ser 
65                  70                  75                  80  


Ala Glu Glu Ile Gly Ile Asp Ile Trp Ser Leu His Ala Asp His Ile 
                85                  90                  95      


Gly Ile Lys Lys Gly Thr Asp Glu Glu Ile Glu Ser Ile Lys Lys Leu 
            100                 105                 110         


Val Lys Ala Gln Ile Asp Ala Gly Tyr Thr Ser Phe Ala Ile Asp Ala 
        115                 120                 125             


Ser His Leu Phe Asn Phe Arg Gly Gly Asn Leu Arg Glu Glu Leu Lys 
    130                 135                 140                 


Asp Asn Ile Glu Ala Thr Thr Lys Val Ala Arg Phe Ile Asp Glu Gln 
145                 150                 155                 160 


Met Glu Asp Arg Asp Tyr Gly Leu Glu Val Glu Val Gly Glu Ile Gly 
                165                 170                 175     


Arg Glu Asp Glu Tyr Gly Arg Val Leu Thr Gln Pro Glu Glu Ala Val 
            180                 185                 190         


Thr Phe Ile Lys Ala Leu Asn Glu Asn Gly Val Tyr Pro Gln Val Leu 
        195                 200                 205             


Ala Ile Ala Asn Gly Ser Ala His Gly Asn Thr Tyr Asp Glu Tyr Gly 
    210                 215                 220                 


His Leu Ile Glu Gln Val Ser Ile Asp Ile Pro Gln Thr Met Ala Val 
225                 230                 235                 240 


Ala Arg Ala Leu Arg Asp Asn Asn Leu Asn Val Arg Ile Ala Gln His 
                245                 250                 255     


Gly Ile Thr Gly Thr Pro Ile Glu Met Ile His Asn His Phe Pro His 
            260                 265                 270         


Gly Asp Ile Ile Lys Gly Asn Val Gly Thr Phe Tyr Leu Asn Leu Val 
        275                 280                 285             


Trp Asp Val Leu Lys Val Phe Glu Pro Gln Leu Tyr Gly Asp Ile Trp 
    290                 295                 300                 


Asp Trp Thr Ile Glu Asn Phe Ser Glu Lys Tyr Pro Asp Lys Ser Glu 
305                 310                 315                 320 


Asn Glu Ile Phe Gly Lys Tyr Ser Lys Tyr Ala Ile Lys Glu Phe Phe 
                325                 330                 335     


Asp Arg Ile Tyr Ser Val Gly Asp Asp Thr Ile Arg Ala Val Glu Ser 
            340                 345                 350         


Arg Ala Tyr Ala Asp Thr Leu Val Phe Leu Lys Ala Phe Lys Ala Ala 
        355                 360                 365             


Gly Met Ala Glu His Val Arg Lys Asn Leu 
    370                 375             


<210>  24
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  24

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Ala Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  25
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  25

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Ala Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  26
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  26

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Gln Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  27
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  27

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Ala 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  28
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  28

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Phe 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  29
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  29

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Ala His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  30
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  30

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asn His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  31
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  31

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp Ala 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  32
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  32

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile Ala Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  33
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  33

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Ala Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  34
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  34

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asn Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  35
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  35

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Ala Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  36
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  36

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Gln Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  37
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  37

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Ala Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  38
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  38

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Gln Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  39
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  39

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala Ala Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  40
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  40

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Ala Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  41
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  41

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asn Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  42
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  42

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Ala Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  43
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  43

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Asp Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Tyr Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  44
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  44

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Ala Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  45
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  45

Met Met Phe Gly Ser Pro Ala Pro Leu Leu Asp Met Val Thr Ala Gln 
1               5                   10                  15      


Lys Gln Gly Met Ala Arg Gly Ile Pro Ser Ile Cys Ser Ala His Pro 
            20                  25                  30          


Val Val Leu Ser Ala Ala Cys His Leu Ala Arg Arg Ser Gly Ala Pro 
        35                  40                  45              


Leu Leu Ile Glu Thr Thr Cys Asn Gln Val Asn His Gln Gly Gly Tyr 
    50                  55                  60                  


Ser Gly Met Thr Pro Ala Asp Phe Val Arg Phe Leu Arg Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Glu Gly Ile Pro Pro Gln Gln Val Ile Leu Gly Gly Asp His 
                85                  90                  95      


Leu Gly Pro Tyr Pro Trp Arg Lys Glu Pro Ala Glu Thr Ala Ile Ala 
            100                 105                 110         


Gln Ala Leu Glu Met Val Arg Ala Tyr Val Gln Ala Gly Tyr Thr Lys 
        115                 120                 125             


Ile His Leu Asp Ala Ser Met Pro Cys Ala Asp Asp Asp Pro Glu Arg 
    130                 135                 140                 


Pro Leu Pro Leu Glu Arg Ile Ala Arg Arg Ala Ala Gln Leu Cys Ala 
145                 150                 155                 160 


Ala Ala Glu Ala Ala Ala Gly Ala Val Gln Pro Val Tyr Val Ile Gly 
                165                 170                 175     


Ser Glu Val Pro Pro Pro Gly Gly Ala Gln Gly Gln Glu Ala Arg Leu 
            180                 185                 190         


His Val Thr Thr Pro Gln Glu Ala Gln Ala Ala Leu Asp Ala Phe Arg 
        195                 200                 205             


Glu Ala Phe Leu Gln Ala Gly Leu Thr Pro Val Trp Glu Arg Val Ile 
    210                 215                 220                 


Ala Leu Val Val Gln Pro Gly Val Glu Phe Gly Val Asp Ser Ile His 
225                 230                 235                 240 


Ala Tyr Gln Arg Glu Ala Ala Arg Pro Leu Lys Thr Phe Ile Glu Gly 
                245                 250                 255     


Val Pro Gly Met Val Tyr Glu Ala His Ser Thr Asp Tyr Gln Thr Arg 
            260                 265                 270         


Ala Ser Leu Arg Ala Leu Val Glu Asp His Phe Ser Ile Leu Lys Val 
        275                 280                 285             


Gly Pro Ala Leu Thr Phe Ala Tyr Arg Glu Ala Val Phe Ala Leu Glu 
    290                 295                 300                 


His Ile Glu Arg Glu Ile Leu Gly Arg Gln Asp Met Pro Leu Ser Arg 
305                 310                 315                 320 


Leu Ser Glu Val Leu Asp Glu Val Met Leu Asn Asp Pro Arg His Trp 
                325                 330                 335     


Gln Gly Tyr Phe Ala Gly Ala Pro Ala Glu Gln Ala Leu Ala Arg Arg 
            340                 345                 350         


Tyr Ser Phe Ser Asp Arg Ile Arg Phe Tyr Trp His His Pro Ala Ala 
        355                 360                 365             


Gln Glu Ala Val Arg Arg Leu Leu Ala Asn Leu Ile Glu Thr Pro Pro 
    370                 375                 380                 


Pro Leu Ser Leu Leu Ser Gln Tyr Leu Pro Arg Glu Tyr Glu Met Val 
385                 390                 395                 400 


Arg Ala Gly Glu Ile Ser Ser His Pro Gln Asp Leu Ile Arg Ala His 
                405                 410                 415     


Ile Gln His Thr Leu Glu Asp Tyr Ala Ala Ala Cys Gly 
            420                 425                 


<210>  46
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  46

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Ala 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Thr Leu Ser Val Leu 
            180                 185                 190         


Lys Lys Ala Phe Lys Asp Leu Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Met Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Ala His Ser Thr Asp Tyr Gln Asp Arg Tyr Ala 
                245                 250                 255     


Leu Arg Ala Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Ser Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Gln Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  47
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  47

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Leu Glu Lys Ile Ala Glu Arg Thr Val Glu 
    130                 135                 140                 


Leu Phe Lys Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Ser Tyr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Ile Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Ala His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Phe Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Asn Leu 
                405             


<210>  48
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  48

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Ala Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Ala Ala Arg Lys Tyr Asn Phe Gln Ala 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Met Ile Ser Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Lys Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Lys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  49
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  49

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Val Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Asp Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ser Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Gln Tyr Phe Asp Val Arg Glu Gly Lys Leu Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  50
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  50

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Glu 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Leu Ser Ile Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Leu Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Lys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  51
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  51

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Lys Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  52
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  52

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Ser Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Glu Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  53
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  53

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Glu 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Ser Ile Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Lys Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Ala His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  54
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  54

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Lys Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Ala His Ser Thr Asp Tyr Gln Ser Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Val Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Lys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Pro Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Tyr Tyr Ala Ile Asn Leu 
                405             


<210>  55
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  55

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Cys Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Asp Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Pro Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  56
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  56

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Ser Leu Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Gln Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  57
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  57

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Leu Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  58
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  58

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ala Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Pro Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  59
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  59

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Pro Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Leu Leu 
            180                 185                 190         


Lys Lys Tyr Phe Glu Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  60
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  60

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Ser Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  61
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  61

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Ala Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Pro Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  62
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  62

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Ala Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Met Ile Ser Val Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Ala 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ser Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Val Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Glu Leu Glu Leu Asp Leu Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Arg Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  63
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  63

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Glu Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Ala Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Ala His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Pro Glu Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Leu Ser Asp Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Leu Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  64
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  64

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Arg Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Thr Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Lys Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Ala His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asp Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  65
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  65

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Ala Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ile Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Arg Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  66
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  66

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Arg Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  67
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  67

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Cys Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Val Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Thr Ile Ser Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Lys Asp His Pro Asn Ile Trp Asp Arg Val Val Ala 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Cys His Ser Thr Asp Tyr Gln Ser Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Val Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asp Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Asp Gly Ile Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Arg Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  68
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  68

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Ile Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Met Ile Ser Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Trp Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Asp Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ala Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  69
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  69

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Ala 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Cys Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  70
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  70

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Asp Glu Ala Met Glu Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Cys Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Thr Ile Ser Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Glu Asp His Pro Asn Met Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Val Gly Phe Ser His Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Asp Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Trp Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Pro Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Pro Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Cys Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  71
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  71

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Asp Gly Asp Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Cys Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Cys Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser His Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Trp Met Val Glu Asp Gly Val Val Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Ser Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Pro Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  72
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  72

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Thr Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Asp Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Leu Ser Glu Gly Val Asp Ile Lys Leu Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  73
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  73

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Glu Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Cys Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Thr Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser His Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Trp Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Pro Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  74
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  74

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Trp Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Cys Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Thr Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser His Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Leu Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  75
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  75

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Glu Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp His Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser His Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Trp Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  76
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  76

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Glu Ala Met Glu Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Thr Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Gly Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  77
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  77

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Phe Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Tyr Val Glu 
            100                 105                 110         


Ser Gly Phe Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Met Glu Lys Ile Ala Glu Arg Thr Ala Glu 
    130                 135                 140                 


Leu Phe Lys Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Tyr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Ala His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Phe Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Lys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Asn Leu 
                405             


<210>  78
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  78

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Phe Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Leu Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ser Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Thr Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Leu Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  79
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  79

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Lys Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Ala 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Ala Glu Asp Phe Arg Ser Ala Ile Ser Ile Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Asp Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Ala His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Glu Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Lys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  80
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  80

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Ala Glu 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ile Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Leu Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  81
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  81

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Met Ile Ser Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Lys Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Glu Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Asn Leu 
                405             


<210>  82
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  82

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Asn Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Val Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Asp Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Lys Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Ala His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Pro Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Tyr Tyr Ala Ile Asn Leu 
                405             


<210>  83
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  83

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Lys Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Val Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Ile Pro Asn Ile Trp Asp Arg Val Val Ala 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Leu Glu Ala His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Ala Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Pro Asp Gln Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  84
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  84

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Leu Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Glu Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Lys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Gln Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  85
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  85

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Thr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Phe 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Asp Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Pro Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  86
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  86

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Asp Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Pro Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  87
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  87

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Glu Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Pro Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Glu Ala Ile Glu Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  88
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  88

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Leu Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Asp Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Asp Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  89
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  89

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Arg Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  90
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  90

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Cys Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Asn Leu 
                405             


<210>  91
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  91

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Trp Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Glu Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Val His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Glu Leu Glu Leu Asp Leu Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Pro Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Arg Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  92
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  92

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Glu Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Thr Ile Ser Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Glu Asp His Pro Arg Ile Trp Asp Arg Val Val Ala 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Cys His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asp Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Glu Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Ala Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Arg Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Cys Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  93
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  93

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Ile Arg Thr Ala Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Met Ile Ser Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Trp Phe Val Glu Ala His Ser Thr Asp Tyr Gln Pro Arg Tyr Ala 
                245                 250                 255     


Leu Arg Trp Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Glu Leu Glu Leu Asp Ile Trp Tyr Ala Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Asp Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Cys Glu Gly Lys Met Lys 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  94
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  94

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Val Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Ser Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Cys Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Leu Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Ala Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Leu Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  95
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  95

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Ala Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Met Ile Ser Val Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Val Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Trp Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asp Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Ala Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Lys Lys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Ile Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  96
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  96

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Thr Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Met Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Cys Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  97
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  97

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Ala Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Lys Lys Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  98
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  98

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Trp Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Asp Gly Asp Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Cys Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Thr Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Asp Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Ala Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Glu Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Pro Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys His Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  99
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  99

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Trp Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Thr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Glu Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Leu Leu 
            180                 185                 190         


Lys Lys Tyr Phe Glu Asp His Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Pro Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Glu Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asp Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Thr Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Cys Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  100
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  100

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Glu Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Lys Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Thr Ile Glu Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser His Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Asp Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn His Glu Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Asp Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys His Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  101
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  101

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Trp Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Ser Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Asp Thr Ala Met Glu Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Cys Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Glu Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser His Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Pro Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ser Arg Asp Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Glu Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Thr Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Arg Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  102
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  102

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Trp Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Gly Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr His Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  103
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  103

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Ile Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Glu Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Cys Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Cys Arg Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Thr Ile Glu Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ala Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Pro Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Trp Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Glu Glu Arg Ser Asn Ile Lys Glu Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile His Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Lys Ala Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Asp Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ala Tyr His Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  104
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  104

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Glu Ala Met Glu Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Cys Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser His Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Thr Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Tyr Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Pro Asp Val Lys Ala Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Leu Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  105
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  105

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Asp Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Leu Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Tyr Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Met Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Lys Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Leu Leu 
            180                 185                 190         


Lys Lys Tyr Phe Lys Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Lys Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Leu Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Phe Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Lys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Pro Asp Ser Tyr Lys Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  106
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  106

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Lys Glu Lys Ile Ala Glu Arg Thr Val Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Asp Ile Leu Glu Glu Leu Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Lys Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Thr Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Leu Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  107
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  107

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Leu Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Val Phe 
            180                 185                 190         


Lys Lys Tyr Phe Lys Asp Leu Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Val Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Gln Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  108
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  108

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Val Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Asp Ile Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Lys Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Glu Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Lys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  109
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  109

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Leu Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Met Ile Asp Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Glu Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Glu Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Gln Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  110
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  110

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Glu Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Leu Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Lys Val Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Phe 
            180                 185                 190         


Lys Lys Tyr Phe Lys Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Asp Arg Lys Ala 
                245                 250                 255     


Leu Arg Asp Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Lys Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Lys Cys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Gln Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  111
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  111

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Glu Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Leu Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Glu Ala Ile Glu Tyr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Glu Asp Leu Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Asp Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Asp Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Asp Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Pro Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  112
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  112

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Leu Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Glu Ala Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Thr Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  113
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  113

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Glu Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Met Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Lys Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Pro Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Lys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Asn Leu 
                405             


<210>  114
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  114

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Glu Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Thr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Glu Ala Ile Glu Ser Phe 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Asp Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Asp Ile Ala Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Lys Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Arg Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  115
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  115

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Glu Ala Met Ala Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Val Leu 
            180                 185                 190         


Lys Lys Tyr Phe Lys Asp Leu Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Met Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Ala His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Trp Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asp Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


His Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Ser Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Pro Asp Val Lys Ala Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  116
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  116

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Cys Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Glu Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Phe Ile Ser Val Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ser Arg Glu Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Asp Asn Ile 
        275                 280                 285             


Glu Lys Asp Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Ser Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Leu Ser Glu Gly Ile Asp Ile Lys Leu Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Thr Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  117
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  117

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Asp Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Gln Glu Lys Ile Ala Glu Arg Thr Ala Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Thr Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Lys Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Ala His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asp Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Pro Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Phe Asp Ile Trp Tyr Ala Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Ala Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Pro Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  118
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  118

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Glu Ala Met Ala Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Val Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Ala 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Val His Ser Thr Asp Tyr Gln Ser Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Val Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


His Asp Ser Lys Asp Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Leu Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  119
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  119

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Trp Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Ala Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Ala Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Leu Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Asp Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Arg Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  120
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  120

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Ser Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln His Glu Pro Ser 
                85                  90                  95      


Asp Thr Ala Met Glu Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Phe Lys Lys Ile His Ile Asp Cys Ser Met Pro Cys Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Asn Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Arg Thr Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp His Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser His Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Ala His Ser Thr Asp Tyr Gln Ala Arg Glu Ala 
                245                 250                 255     


Leu Arg Trp Met Val Glu Asp Gly Val Ala Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asp Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Asp Arg Leu Glu Leu Asp Ile His Tyr Ser Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Ala Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Asp Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Leu Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys His Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Asn Leu 
                405             


<210>  121
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  121

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Trp Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Glu Ala Met Asn Lys Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Cys Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Lys Ala Ile Glu Ala Leu 
            180                 185                 190         


Lys Lys Tyr Phe Ala Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Asp Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Tyr Arg Arg Ser Asn Ile Lys Glu Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Lys Ala Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Leu Ser Glu Gly Val Asp Ile Lys Leu Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  122
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  122

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Ile Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Asp Gly Asp Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Tyr Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Asp Glu Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Cys Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Leu His 
            180                 185                 190         


Lys Lys Tyr Phe Lys Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser His Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Asp Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Trp Met Val Glu Asp Gly Val Ala Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Asp Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Glu Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Ser Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Pro Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Leu Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys His Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  123
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  123

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Trp Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Ala Arg 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Thr Ile Ser Ala Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp His Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser His Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Ala Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Trp Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asp Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Glu Arg Leu Arg Leu Asp Ile His Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Pro Asp Val Lys Glu Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Asp Gly Val Asp Trp Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr His Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  124
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  124

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Trp Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Tyr Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asn Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ala Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Thr Ile Glu Ala Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser His Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Gln Asp Gly Val Ala Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Tyr Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Ser Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Pro Asp Val Lys Ala Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Pro Ile Thr Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Asn Leu 
                405             


<210>  125
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  125

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Lys Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Lys Glu Lys Ile Ala Glu Arg Thr Val Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Gln Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Lys Glu Asp Phe Arg Ser Phe Ile Ser Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asp Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Leu Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Asp Arg Gln Ala 
                245                 250                 255     


Leu Arg Arg Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Ile Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Gln Glu Leu Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Lys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Gln Tyr Phe Asp Val Arg Glu Gly Lys Leu Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  126
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  126

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Phe Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Lys Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Met His Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Leu Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Cys Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Ala 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Thr Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Ala Phe Lys Asp Leu Pro Lys Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Lys Leu 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Gln Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  127
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  127

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Asp Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Phe Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Lys Val Ala Glu Glu Ala Ala Arg Lys Tyr Asn Phe Gln Ala 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Met Ile Glu Val Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Ile Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Lys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  128
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  128

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Met Gly Asp Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Phe Lys Ile Ala Lys Glu Lys Gly Leu Pro Pro Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Glu Ala Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Asp Tyr Phe 
            180                 185                 190         


Lys Lys Tyr Phe Lys Asp Val Pro Asn Ala Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Gly Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Asp Arg Tyr Ala 
                245                 250                 255     


Leu Arg Glu Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Asp Lys Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Glu Arg Leu Arg Leu Asp Ile Trp Tyr Ser Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Pro Asp Val Lys Met Ala Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Pro Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  129
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  129

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Phe Lys Ile Ala Lys Glu Lys Gly Leu Pro Pro Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Asp Glu Lys Ile Ala Glu Arg Glu Arg Glu 
    130                 135                 140                 


Leu Phe Lys Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Arg Phe Ile Glu Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Pro Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Asp Arg Gln Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ala Asn Ile 
        275                 280                 285             


Glu Asn Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Glu Arg Leu Arg Leu Asp Ile Trp Tyr Asn Tyr Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Lys Lys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  130
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  130

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Phe Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Gln Ala Met Glu Lys Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Pro Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Gln Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Glu Phe Arg Asn Met Ile Glu Ser Phe 
            180                 185                 190         


Lys Lys Tyr Phe Asp Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Gly Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Asp Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ser Arg Lys Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asn Glu Ile Ile Pro Glu Arg Lys Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Arg Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Lys Ala Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  131
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  131

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ala Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Asp Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Glu Ala Met Ala Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Ala Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Ser Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Ala His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Trp Met Val Glu Asp Gly Val Val Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asp Ile 
        275                 280                 285             


Glu Ala Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Thr Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Lys Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Asp Gly Ile Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ala Tyr His Asp Val Cys Glu Gly Lys Met Lys 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Asn Leu 
                405             


<210>  132
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  132

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Tyr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Glu Thr Ala Met Ala Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Lys Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Ser Ala Ile Glu Val Leu 
            180                 185                 190         


Lys Lys Tyr Phe Glu Asp His Pro Asn Ala Trp Asp Arg Val Val Ala 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Cys His Ser Thr Asp Tyr Gln Ala Arg Glu Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asp Ile 
        275                 280                 285             


Glu Lys Glu Ile Ile Pro Glu Arg His Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Ala Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Cys Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Lys Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  133
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  133

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Glu Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ala Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ala Asp 
        115                 120                 125             


Glu Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Ala Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Thr Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp His Pro Arg Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser His Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Val His Ser Thr Asp Tyr Gln Pro Arg Glu Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Val Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asp Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Glu Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Ala Val Leu Glu 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Pro Ala Cys Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  134
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  134

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Trp Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Tyr Gln Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln His Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Ala Lys Ala Lys Asp Leu Ile Arg Ala Tyr Val Glu 
            100                 105                 110         


Ser Gly Phe Lys Lys Ile His Ile Asp Cys Ser Met Pro Cys Ser Gly 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Ala Arg 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Arg Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Lys Ala Ile Glu Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp His Pro Asn Ala Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Val Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Pro Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Ala Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ala Asp Ile 
        275                 280                 285             


Glu Lys Glu Ile Ile Pro Glu Arg His Arg Ser Asn Ile Lys Glu Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Glu Asn Leu Arg Leu Asp Ile Trp Tyr Ser Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu His Pro Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Cys Tyr His Ala Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  135
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  135

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Ile Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Trp Val Ile Glu Ala Ala Ile Glu His Ala Lys 
            20                  25                  30          


Glu Asp Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Thr Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Pro Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln His Glu Pro Ala 
                85                  90                  95      


Glu Glu Ala Met Glu Lys Ala Lys Glu Leu Ile Arg Ala Tyr Val Glu 
            100                 105                 110         


Ser Gly Phe Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Ala Val Leu Pro Tyr Asp Lys Ile Ala Glu Arg Thr Ala Glu 
    130                 135                 140                 


Leu Cys Arg Val Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Lys Ala Ile Ser Ser Phe 
            180                 185                 190         


Lys Lys Tyr Phe Gln Asp Val Pro Gln Ile Trp Asn Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Asp Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Pro Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Asn Arg Asp Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Glu Gly Val Phe Leu Leu Ala Asp Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Glu Gln Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Gln Leu Arg Trp Asp Ile Trp Tyr Ser Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Glu Asp Val Lys Met Ala Leu Glu 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Pro Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ala Tyr Phe Asp Val Arg Glu Gly Lys Leu Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  136
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  136

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Ile Tyr Ser Val 
1               5                   10                  15      


Cys Ser Ser Asn Pro Trp Val Ile Glu Ala Ala Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Ser Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Tyr Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asn Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln His Glu Pro Ser 
                85                  90                  95      


Pro Glu Ala Met Ala Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Cys Ala Gly 
        115                 120                 125             


Asp Pro Ala Val Leu Pro Gln Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Cys Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Pro Glu Asp Phe Arg Lys Ala Ile Ser Ser Phe 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp His Gly Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Ala Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Asp Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Ala Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Gln Arg Ser Asn Ile Lys Glu Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Asn Leu Glu Leu Asp Ile His Tyr Ser Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn His Glu Asp Val Lys Met Val Leu Glu 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Ile Asp Trp Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Arg Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr His Tyr Ala Ile Asn Leu 
                405             


<210>  137
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  137

Met Trp Leu Ser Ala Asp Tyr Leu Arg Asn Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Gln Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  138
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  138

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Leu 
            20                  25                  30          


Glu Met Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Gln Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Gln Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  139
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  139

Met Trp Leu Ser Lys Asp Tyr Leu Arg Asn Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Glu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Glu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Asp 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  140
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  140

Met Trp Leu Ser Phe Asp Tyr Leu Arg Met Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Ile Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Ser 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  141
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  141

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Gln Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  142
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  142

Met Trp Leu Ser Lys Asp Tyr Leu Arg Asn Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Ala Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Thr 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  143
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  143

Met Trp Leu Ser Leu Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Gly Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Met Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Leu Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Gln Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  144
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  144

Met Trp Leu Ser Lys Asp Tyr Leu Arg Asn Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Thr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr His Lys Ile His Ile Asp Thr Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Thr Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Glu Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  145
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  145

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Gln Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Val Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Arg Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Thr Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  146
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  146

Met Trp Leu Ser Lys Asp Tyr Leu Arg Arg Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Thr Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  147
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  147

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  148
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  148

Met Trp Leu Ser Lys Asp Tyr Leu Arg Asn Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Leu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Ser 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  149
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  149

Met Trp Leu Ser Lys Asp Tyr Leu Arg Asn Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Leu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Tyr Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Gln Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Val Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys His Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  150
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  150

Met Trp Leu Ser Trp Asp Tyr Leu Arg Arg Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Gln Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Ile Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  151
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  151

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Asn Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Leu Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Thr Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Gln Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Asp 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  152
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  152

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Gln Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Gln Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Thr Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Glu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  153
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  153

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Ile Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  154
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  154

Met Trp Leu Ser Met Asp Tyr Leu Arg Leu Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Trp Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile His Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Asp 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Arg Lys Glu Ile Met Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  155
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  155

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Asn Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Asn Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  156
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  156

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Arg Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  157
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  157

Met Trp Leu Ser His Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Trp Ile His Ile Asp Ala Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Asn Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Ser 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Leu Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  158
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  158

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Asn Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Gln Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Ser Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  159
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  159

Met Trp Leu Ser Leu Asp Tyr Leu Arg Asn Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Gln Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Glu Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Asp 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  160
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  160

Met Trp Leu Ser Lys Asp Tyr Leu Arg Asn Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Ala Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Glu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  161
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  161

Met Trp Leu Ser His Asp Tyr Leu Arg Lys Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Thr Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Glu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Tyr Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  162
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  162

Met Trp Leu Ser Phe Asp Tyr Leu Arg Asn Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Ala Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Gln Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Lys Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Thr Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Gln Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  163
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  163

Met Trp Leu Ser Phe Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Gln Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Thr Gly Leu Glu Glu Asp Gln Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Thr Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Asn Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Thr Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  164
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  164

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Gln Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Ile Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Asn Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Gln Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Val Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys His Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  165
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  165

Met Trp Leu Ser Trp Asp Tyr Leu Arg Arg Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Glu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Arg Thr Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Gln Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Glu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  166
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  166

Met Trp Leu Ser Lys Asp Tyr Leu Arg Leu Tyr Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Thr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Tyr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Tyr Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Ala Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Trp Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Leu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  167
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  167

Met Trp Leu Ser Ala Asp Tyr Leu Arg Lys Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Glu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Gln Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Thr 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  168
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  168

Met Trp Leu Ser Ala Asp Tyr Leu Arg Asn Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Gln Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Glu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Thr Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  169
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  169

Met Trp Leu Ser Phe Asp Tyr Leu Arg Asn Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Ile Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Gln Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Gln Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Thr Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Thr Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Ile Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Gln Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Glu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  170
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  170

Met Trp Leu Ser Ala Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Tyr Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Lys Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Leu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Ala Thr Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Ile Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Thr 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  171
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  171

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Leu Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Val Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Met Leu Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  172
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  172

Met Trp Leu Ser Phe Asp Tyr Leu Arg Lys Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Gln Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Gln Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Thr Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Gln Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Asp 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  173
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  173

Met Trp Leu Ser Phe Asp Tyr Leu Arg Met Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Leu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Gln Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Val Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Trp Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Trp Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Ser 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  174
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  174

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Tyr Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Leu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Val Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Leu Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  175
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  175

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Ile Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Thr Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Glu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  176
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  176

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Leu 
            20                  25                  30          


Glu Tyr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Gln Glu Lys Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Arg Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  177
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  177

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Leu 
            20                  25                  30          


Glu Met Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Gln Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Ser Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Ile Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  178
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  178

Met Trp Leu Ser Lys Asp Tyr Leu Arg Leu Tyr Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Tyr Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Met Ile His Ile Asp Val Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Tyr Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Ala Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Thr Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Val Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Trp Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile His Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Lys Glu Ile Met Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  179
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  179

Met Trp Leu Ser Lys Asp Tyr Leu Arg Asn Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Gly Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Leu 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Ile Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Thr 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  180
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  180

Met Trp Leu Ser Lys Asp Tyr Leu Arg Asn Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Leu 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Gln Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Glu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  181
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  181

Met Trp Leu Ser Leu Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Leu Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Tyr Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  182
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  182

Met Trp Leu Ser Met Asp Tyr Leu Arg Leu Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Leu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Ile Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Asn Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Ser Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Val Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  183
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  183

Met Trp Leu Ser Lys Asp Tyr Leu Arg Asn Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Leu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Ile Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Tyr Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Asn Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Gln Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Trp Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Ser 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  184
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  184

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Gly Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Met Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Gln Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Arg Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Ile Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Tyr Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  185
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  185

Met Trp Leu Ser Leu Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Gly Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Thr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Lys Glu Leu Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Asn Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Tyr Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  186
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  186

Met Trp Leu Ser Trp Asp Tyr Leu Arg Val Tyr Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Thr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Phe Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Tyr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Tyr Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Ala Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Ser Val Arg Gly Ile Leu Glu Glu Val Trp Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Trp Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile His Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Asp 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  187
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  187

Met Trp Leu Ser Trp Asp Tyr Leu Arg Lys Tyr Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Thr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Phe Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Tyr Lys Ile His Ile Asp Val Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Ala Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Trp Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Leu Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Asp 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Tyr Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  188
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  188

Met Trp Leu Ser Ala Asp Tyr Leu Arg Asn Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Leu Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Glu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Gln Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Trp Ile His Ile Asp Thr Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Leu Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Asp 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  189
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  189

Met Trp Leu Ser Leu Asp Tyr Leu Arg Ala Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Gly Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Leu 
            20                  25                  30          


Glu Tyr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Gln Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Arg Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Ile Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Met Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  190
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  190

Met Trp Leu Ser Lys Asp Tyr Leu Arg Asn Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Ile Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Leu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Tyr Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Lys Glu Thr Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Leu Trp Ile His Ile Asp Ala Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Asn Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Val Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Ile Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Met Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Trp Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Lys Glu Ile Arg Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  191
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  191

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Glu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Ala Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Glu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Gln Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Asp 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  192
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  192

Met Trp Leu Ser Ala Asp Tyr Leu Arg Leu Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Leu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Val Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Thr 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Arg Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  193
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  193

Met Trp Leu Ser Met Asp Tyr Leu Arg Lys Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Ser Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Leu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Gln Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Tyr Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Gln Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Val Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Trp Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu His Glu Ile Ile Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  194
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  194

Met Trp Leu Ser His Asp Tyr Leu Arg Asn Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Leu 
            20                  25                  30          


Glu Thr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Gln Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  195
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  195

Met Trp Leu Ser Phe Asp Tyr Leu Arg Leu Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Leu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Gln Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Ile Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Asn Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Gln Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Trp Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Trp Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Asp 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  196
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  196

Met Trp Leu Ser Leu Asp Tyr Leu Arg Lys Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Leu 
            20                  25                  30          


Glu Met Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Gln Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Arg Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Tyr Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  197
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  197

Met Trp Leu Ser Trp Asp Tyr Leu Arg Asn Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Thr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Lys Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Gln Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg His Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Glu Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Thr Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Gln Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  198
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  198

Met Trp Leu Ser Leu Asp Tyr Leu Arg Lys Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Glu Thr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Gln Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Ala Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Tyr Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  199
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  199

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Lys Glu Leu Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Ile Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Thr Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Arg Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Ala Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Lys Glu Ile Met Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  200
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  200

Met Trp Leu Ser His Asp Tyr Leu Arg Lys Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Gly Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Glu Thr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Gln Glu Leu Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Leu Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Thr Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Asn Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Tyr Glu Ile Ile Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  201
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  201

Met Trp Leu Ser Phe Asp Tyr Leu Arg Met Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Ile Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Leu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Gln Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Ile Val Ile His Ile Asp Thr Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Glu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Asn Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Gln Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Val Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Ile Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu His Glu Ile Met Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  202
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  202

Met Trp Leu Ser Trp Asp Tyr Leu Arg Asn Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Ile Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Thr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr His Val Ile His Ile Asp Val Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Thr Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg His Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Glu Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Thr Val Arg Gly Ile Leu Glu Glu Val Arg Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Val Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Gln Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile His Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Asp 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  203
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  203

Met Trp Leu Ser Ala Asp Tyr Leu Arg Asn Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Glu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Gln Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Glu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Thr Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Gln Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Gln Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Asp 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  204
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  204

Met Trp Leu Ser Leu Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Gly Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Glu Met Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Leu Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Thr Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Gln Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Asn Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Ile Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Tyr Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  205
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  205

Met Trp Leu Ser Phe Asp Tyr Leu Arg Asn Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Gln Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Gln Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Gln Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Gln Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Thr Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Asn Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Gln Ser Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Thr Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Gln Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Glu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  206
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  206

Met Trp Leu Ser Leu Asp Tyr Leu Arg Asn Glu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Val Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu His Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Gln Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Arg Val Leu Pro Tyr Glu Glu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Thr Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Asn Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Ser Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Gln Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Asn Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  207
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  207

Met Trp Leu Ser Leu Asp Tyr Leu Arg Asn Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Ile Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ser 
            20                  25                  30          


Glu Phe Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Gln Ile Ala Arg Glu Ile Gly Leu Glu Glu Asp Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Phe Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Trp Val Ile His Ile Asp Ala Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Arg Val Leu Pro Tyr Glu Glu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Ala Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Val Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Ser Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Asn Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Phe Glu Ile Phe Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  208
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  208

Met Trp Leu Ser Leu Asp Tyr Leu Arg Asn Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Leu 
            20                  25                  30          


Glu Met Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Gln Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Gln Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Ile Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Glu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  209
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  209

Met Trp Leu Ser Leu Asp Tyr Leu Arg Ala Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Glu Thr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Gln Glu Lys Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Ile Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Ala Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Glu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  210
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  210

Met Trp Leu Ser Trp Asp Tyr Leu Arg Arg Arg Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Gln Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Gln Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Glu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Asp Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Arg Thr Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Thr Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Gln Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Glu Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Glu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  211
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  211

Met Trp Leu Ser Met Asp Tyr Leu Arg Met Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Ser Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Leu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Ile Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Tyr Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Asn Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Ala Ser Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Trp Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Tyr Glu Ile Met Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  212
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  212

Met Trp Leu Ser Phe Asp Tyr Leu Arg Leu Leu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Leu Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Tyr Asn Phe 
    50                  55                  60                  


Val Met Gln Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Val Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Leu Val Leu Pro Tyr Glu Glu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Val Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Ala Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Met Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Ser Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Tyr Glu Ile Ile Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  213
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  213

Met Trp Leu Ser Leu Asp Tyr Leu Arg Asn Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Ser Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Arg Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Leu Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Gln Val Ile His Ile Asp Thr Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Glu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Ser Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Ser Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Val Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Gln Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Ser Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  214
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  214

Met Trp Leu Ser Leu Asp Tyr Leu Arg Ala Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Gly Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Leu 
            20                  25                  30          


Glu Tyr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Gln Glu Leu Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Arg Val Leu Pro Tyr Glu Ile Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Asn Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Tyr Glu Ile Ile Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  215
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  215

Met Trp Leu Ser Ala Asp Tyr Leu Arg Asn Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Gly Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Glu Thr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Gln Glu Leu Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Ile Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Thr 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Tyr Glu Ile Ile Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  216
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  216

Met Trp Leu Ser Ala Asp Tyr Leu Arg Asn Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Gly Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Glu Met Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Gln Glu Leu Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Ile Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Ser Leu Ile His Ile Asp Thr Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Ala Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Asn Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Tyr Glu Ile Ile Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  217
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  217

Met Trp Leu Ser Leu Asp Tyr Leu Arg Arg Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Gly Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Glu Met Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Val Asn Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Gln Glu Leu Gly Leu Glu Glu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Leu Ile His Ile Asp Thr Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Arg Val Leu Pro Tyr Glu Leu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Arg Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Ile Ala Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Asn Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Leu Met Val Leu Asn 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Tyr Glu Ile Ile Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  218
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  218

Met Trp Leu Ser Arg Asp Tyr Leu Arg Arg Arg Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Arg 
            20                  25                  30          


Glu Arg Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Arg Val Leu Pro Tyr Glu Arg Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Arg Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Arg Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Arg Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Arg Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Arg Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  219
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  219

Met Trp Leu Ser Arg Asp Tyr Leu Arg Arg Arg Gly Val Tyr Ser Ile 
1               5                   10                  15      


Arg Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Arg 
            20                  25                  30          


Glu Arg Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Glu Arg Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Arg Val Leu Pro Tyr Glu Arg Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Arg Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Arg Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Arg Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Arg Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Arg Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Arg Arg Glu Ile Arg Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  220
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  220

Met Trp Leu Ser Arg Asp Tyr Leu Arg Arg Arg Gly Val Tyr Ser Ile 
1               5                   10                  15      


Arg Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Arg 
            20                  25                  30          


Glu Arg Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Asn Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Glu Arg Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Arg Ile His Ile Asp Arg Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Arg Val Leu Pro Tyr Glu Arg Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Arg Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Arg Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Gly Ile Leu Glu Glu Val Arg Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Arg Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Arg Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Arg Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Arg Met Val Leu Asn 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Arg Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Arg Arg Glu Ile Arg Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  221
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  221

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  222
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  222

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  223
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  223

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Thr Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  224
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  224

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Gln Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Val Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  225
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  225

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Leu Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Leu Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  226
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  226

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Gly Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Tyr Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  227
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  227

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Ser Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Val Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  228
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  228

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Arg Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Gln Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  229
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  229

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Gly Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Leu Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Gln Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Asn Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  230
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  230

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Gly Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Asn Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  231
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  231

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Phe Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Ala Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Ala Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  232
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  232

Met Trp Glu Arg Arg Glu Asn Gly Gln Arg Glu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Arg Ala Ser Ile Arg Phe Ala Arg 
            20                  25                  30          


Glu Arg His Asp Arg Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Arg Glu 
    50                  55                  60                  


Val Glu Arg Ile Ala Arg Glu Glu Gly Leu Asp Glu Arg Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Arg 
                85                  90                  95      


Pro Glu Ala Met Asn Glu Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Asp Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Glu Pro Glu Val Leu Asp Tyr Arg Glu Ile Ala Glu Gln Thr Arg Gln 
    130                 135                 140                 


Leu Phe Glu Glu Ala Glu Arg Arg Arg Thr Glu Arg Asp Arg Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Arg Ala Ile Glu Tyr Leu 
            180                 185                 190         


Glu Arg Tyr Phe Pro Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Thr Arg Asp Arg Val Phe Gln 
    210                 215                 220                 


Tyr Asp Arg Glu Glu Val Arg Arg Ile Leu Glu Glu Val Arg Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Arg Arg Gln Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Thr Ser Asp Glu His Arg Arg Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Pro Glu Phe Ile Arg 
        355                 360                 365             


Glu Tyr Phe Tyr Arg Ser Tyr Glu Arg Val Arg Asp Gly Glu Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Glu Glu Glu Ile Arg Gln Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Asp Arg 
                405             


<210>  233
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  233

Met Trp Glu Arg Arg Arg His Gly Glu Glu Arg Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Arg Ala Ser Ile Glu Phe Ala Arg 
            20                  25                  30          


Gln Arg Gly Arg Asp Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln His Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Arg Glu Glu Gly Leu Asp Glu Arg Arg Ile Arg 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Gln Glu Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Gln Glu Glu Ile Ala Arg Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Arg Arg Arg Gln Glu Tyr Glu Glu Glu Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Arg Ala Ile Glu His Leu 
            180                 185                 190         


Glu Glu Tyr Phe Pro Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Thr Arg Asp Arg Val Phe Gln 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Arg Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Arg Arg Gln Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Glu Thr Ser Asp Gln Leu Arg Leu Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Glu Arg Arg Ile Tyr 
        355                 360                 365             


Glu Tyr Phe Tyr Glu Ser Tyr Gln Asp Val Arg Asp Gly Arg Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Arg Glu Glu Ile Arg Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Glu Tyr Ala Ile Asp Gly 
                405             


<210>  234
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  234

Met Trp Leu Arg Lys Gln Asn Asn Glu Pro Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Leu Ser Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Phe Gln Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Arg Ser Lys Gly Leu Asp Glu Arg Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Glu 
                85                  90                  95      


Pro Gln Ala Met Glu Tyr Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Gln Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Asp Trp Arg Arg Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Thr Ser Pro Pro Val Pro Asn Thr Ile 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Thr Leu 
            180                 185                 190         


Glu Arg Tyr Phe Glu Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Asn Phe Ser Tyr Arg Thr Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Glu Glu Ile Leu Arg Glu Val Glu Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Glu Asn Met Val Arg Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Gln Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg His Arg Ser Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Pro Gln Leu Glu Glu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Glu Glu Val Leu Arg 
            340                 345                 350         


Gln Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Asn Gly Asn Met Asp 
    370                 375                 380                 


Thr Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Gln Leu 
                405             


<210>  235
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  235

Met Trp Leu Arg Gln Arg Asn Gly Glu Pro Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Ser Asn Thr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Arg Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Glu Glu Ile Ala Arg Ser Lys Gly Leu Asp Glu Arg Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Gln Glu Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Ser Glu Thr Leu Asp Tyr Arg Glu Ile Ala Arg Gln Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Glu Ala Glu Glu Thr Ala Thr Thr Asp Pro Asn Glu Thr 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Arg Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Glu Leu 
            180                 185                 190         


Glu Arg Tyr Phe Arg Asp Val Asp Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Thr Phe Ser Arg Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Arg Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Arg Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg His Arg Ser Asn Ile Glu Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asn Tyr Tyr 
305                 310                 315                 320 


Glu Asp Ser Asp Gln Leu Arg Glu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Gln Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Asp Gly Arg Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Glu Leu 
                405             


<210>  236
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  236

Met Trp Leu Arg His Gln Asn Asn Glu Pro Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Ser Asn Ser Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln His Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Glu Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Ser Lys Gly Leu Asp Glu Arg Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Gln Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Gln Glu Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Leu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Glu Thr Leu Asp Tyr Arg Glu Ile Ala Arg His Thr Arg Glu 
    130                 135                 140                 


Leu Phe Gln Ile Ala Glu Glu Thr Ser Pro Pro Arg Pro Asn Gln Thr 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Ala Leu 
            180                 185                 190         


Glu Arg Tyr Phe Glu Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Asn Phe Ser Tyr Arg Glu Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Glu Glu Ile Leu Arg Glu Val Glu Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Gln Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg His Arg Ser Asn Ile Gln Glu Val 
    290                 295                 300                 


Ile Leu Gln Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Pro Gln Leu Glu Glu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Glu Glu Val Leu Arg 
            340                 345                 350         


Gln Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Glu Leu 
                405             


<210>  237
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  237

Met Trp Leu Arg Gln Arg Asn Gly Gln Arg Trp Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Arg Ala Ser Ile Arg Phe Ala Lys 
            20                  25                  30          


Gln Arg Asp Gln Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Arg Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Glu Gln Ile Ala Arg Glu Glu Gly Leu Glu Pro Arg Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Glu Glu Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Glu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Ser Glu Thr Leu Asp Tyr Arg Glu Ile Ala Arg Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Glu Ala Glu Glu Thr Ala Thr Thr Asp Pro Asn Arg Thr 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Arg Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Tyr Leu 
            180                 185                 190         


Arg Gln Tyr Phe Gln Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Thr Phe Ser Arg Arg Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Arg Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Arg Arg Ser Asn Ile Arg Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Glu Asp Ser Asp Glu Leu Glu Glu Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Arg Val Leu Glu 
            340                 345                 350         


Glu Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Phe His Val Arg Asp Gly Arg Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Glu Gln Glu Ile Arg Glu Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Glu Leu 
                405             


<210>  238
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  238

Met Trp Leu Glu Arg His Tyr Asn Leu Glu Arg Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Arg 
            20                  25                  30          


Asn Arg His Leu Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Ile Phe Gly Gly Tyr Ser Gly Met Thr Pro Thr Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Met Asp Ile Ala Arg Arg Lys Gly Leu Asp Glu Arg Asp Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ala 
                85                  90                  95      


Pro Glu Ala Met Asp Arg Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Glu Val Leu His Trp Asp Glu Ile Ala Glu Leu Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Val Ala Glu Glu Val Ala Gln Asp Tyr Pro Asn Leu Leu 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Ala Leu 
            180                 185                 190         


Arg Arg Tyr Phe Asn Asp Val Leu Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Asp Arg Val Phe Met 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Glu Ile Leu Glu Glu Val Arg Arg Val 
225                 230                 235                 240 


Pro Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Gln Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Arg Arg Ser Glu Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Tyr Trp Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Thr Val Leu Glu 
            340                 345                 350         


Arg Leu Phe Arg Asn Phe Ser Glu Pro Val Pro Leu Glu His Ile Arg 
        355                 360                 365             


Asp Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Asp Gly Arg Met Glu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Asp Thr 
                405             


<210>  239
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  239

Met Trp Glu Arg Arg Glu Tyr Gly Gln Arg Glu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Arg Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Arg 
            20                  25                  30          


Thr Arg His Asp Arg Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Glu 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Glu Lys Gly Leu Asp Glu Arg Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Arg 
                85                  90                  95      


Pro Glu Ala Met Asn Glu Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Glu Pro Lys Val Leu Pro Trp Glu Glu Ile Ala Glu Gln Thr Arg Gln 
    130                 135                 140                 


Leu Phe Glu Glu Ala Glu Arg Arg Arg Thr Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Glu Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Arg Ala Ile Glu Glu Leu 
            180                 185                 190         


Lys Arg Tyr Phe Pro Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Arg Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Gln Ile Pro Glu Arg Glu Arg Gln Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Thr Ser Asp Arg His Arg Glu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Arg Val Leu Glu 
            340                 345                 350         


Glu Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Pro Glu Phe Ile Arg 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Asn Gly Arg Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Glu Arg 
                405             


<210>  240
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  240

Met Trp Leu Arg His Gln Tyr Gly Gln Glu Glu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Arg Ala Ser Ile Arg Phe Ala Gln 
            20                  25                  30          


Arg Lys His Glu Arg Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Arg Asp Phe Arg Glu Glu 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Glu Glu Gly Leu Asp Glu Arg Gln Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Arg 
                85                  90                  95      


Pro Glu Ala Met Asn Glu Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Glu Pro Lys Val Leu Pro Tyr Glu Glu Ile Ala Arg Gln Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Glu Ala Glu Arg Arg Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Glu Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Arg Ala Ile Glu Glu Leu 
            180                 185                 190         


Lys Arg Tyr Phe Pro Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Arg Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Arg Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Gln Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Gln Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Thr Ser Asp Arg His Arg Glu Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Arg Ser Tyr Glu Asp Val Arg Glu Gly Arg Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile His Arg Glu Ile Glu Glu Val Leu Gln 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Glu Arg 
                405             


<210>  241
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  241

Met Trp Glu Glu His Arg His Gly Gln Glu Phe Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Gln Gly Thr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Glu Glu Ile Ala Arg Arg Lys Gly Leu Asp Glu Arg Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Gln Pro Arg 
                85                  90                  95      


Pro Thr Ala Met Asn Glu Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Asp Glu Glu Ile Ala Arg Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Glu Ala Glu Arg His Arg Gln Gln Tyr Pro Thr Glu Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Arg Ala Ile Glu Ala Leu 
            180                 185                 190         


Gln Arg Tyr Phe Pro Asp Val Glu Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Thr Arg Asp Arg Val Phe Gln 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Glu Ile Leu Glu Glu Val Arg Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Arg Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Arg Arg Gln Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Glu Thr Ser Lys Gln Leu Glu Glu Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Arg Val Leu Asn 
            340                 345                 350         


Glu Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Gln Asp Val Arg Asp Gly Arg Met Thr 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile His Arg 
                405             


<210>  242
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  242

Met Trp Leu Arg Lys Gln Asn Asn Glu Lys Arg Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Arg 
            20                  25                  30          


Glu Arg Asn Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Arg Ser Lys Gly Leu Asp Glu Arg Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ser 
                85                  90                  95      


Pro Glu Ala Met Arg Arg Ala Glu Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Pro Trp Glu Lys Ile Ala Glu Arg Thr Arg Arg 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Thr Ala Pro Glu Val Pro Asn Glu Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Thr Leu 
            180                 185                 190         


Glu Arg Tyr Phe Glu Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Gln Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg His Arg Ser Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Gln Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Arg Val Leu Glu 
            340                 345                 350         


Glu Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Asn Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Gln Leu 
                405             


<210>  243
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  243

Met Trp Leu Glu Lys Gln Asn Asn Gln Asp Arg Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Arg 
            20                  25                  30          


Glu Arg Asp Gln Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Arg Gln Lys Gly Leu Glu Glu Asp Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Glu 
                85                  90                  95      


Pro Thr Ala Met Glu Lys Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Glu Thr Leu Asp Trp Arg Glu Ile Ala Arg Leu Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Thr Ala Pro Glu Val Pro Asn Glu Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Thr Leu 
            180                 185                 190         


Lys Arg Tyr Phe Ser Asp Val Pro Asn Ile Ala Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Asn Phe Ser Tyr Arg Glu Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Glu Asn Met Val Arg Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Gln Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg His Arg Ser Asn Ile Glu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Gln Leu Glu Glu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Glu Asp Val Arg Arg Val Leu Glu 
            340                 345                 350         


Glu Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Asn Gly Arg Met Glu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Glu Leu 
                405             


<210>  244
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  244

Met Trp Leu Arg His Glu Tyr Gly Gln Arg Glu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Arg Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Thr Arg His Glu Arg Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Glu 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Glu Lys Gly Leu Asp Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Ser 
                85                  90                  95      


Pro Glu Ala Met Glu Glu Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Glu Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Arg Thr Gln Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Glu Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Gln Leu 
            180                 185                 190         


Gln Arg His Phe Pro Asp Val Glu Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Arg Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Arg Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Arg Arg Gln Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asn Tyr Tyr 
305                 310                 315                 320 


Asp Thr Ser Asp Glu His Arg Arg Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Glu Glu Val Leu Arg 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Pro Glu Phe Ile Arg 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Glu Gly Arg Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Glu Arg 
                405             


<210>  245
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  245

Met Trp Leu Glu His His Tyr Gly Arg Pro Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Arg Ala Ser Ile Arg Phe Ala Gln 
            20                  25                  30          


Arg Gln His His Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Glu Gln Ile Ala Arg Glu Glu Gly Leu Glu Glu Arg Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Asn Glu Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Trp Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Ser Glu Thr Leu Asp Tyr Arg Arg Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Glu Ala Glu Glu Thr Ala Arg Gly Tyr Pro Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Arg Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Tyr Leu 
            180                 185                 190         


Arg Gln Tyr Phe Asn Asp Val Arg Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Arg Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Arg Arg His 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Arg Arg Ser Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Glu Thr Ser Glu Gln Leu Glu Arg Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Pro Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Asp Gly Arg Met Gln 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Leu His Glu Ile Glu Glu Val Leu Arg 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Asp 
                405             


<210>  246
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  246

Met Trp Leu Arg His His Tyr Asn Glu Pro Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


His Arg His Glu Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln His Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Arg Arg Lys Gly Leu Asp Glu Arg Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Gln Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Asn Gln Ala Gln Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Leu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Glu Val Leu Pro Tyr Glu Glu Ile Ala Glu His Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Val Ala Glu Glu Thr Ala Gln Asp Tyr Pro Phe Gln Leu 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu His Leu 
            180                 185                 190         


Arg Gln Tyr Phe Arg Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Arg Arg Glu 
225                 230                 235                 240 


Pro Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Gln Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Gln Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Glu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Glu Asp Val Arg Arg Val Leu Glu 
            340                 345                 350         


Arg Leu Phe Arg Asn Phe Ser Glu Pro Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Asp Gly Arg Met Glu 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Asp Thr 
                405             


<210>  247
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  247

Met Trp Glu Glu Lys Arg His Gly Arg Glu Arg Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Glu Met Gly Tyr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Trp Ser Gly Gly Tyr Ser Gly Trp Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Glu Glu Ile Ala Arg Arg Lys Gly Leu Asp Pro Asp Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Glu 
                85                  90                  95      


Pro Arg Ala Met Glu Tyr Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Leu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Arg Pro Asp Glu Leu Pro Arg Glu Glu Ile Ala Arg Trp Thr Arg Asp 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Tyr Arg Gln Thr Phe Arg Thr Glu Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Tyr Leu 
            180                 185                 190         


Gln Arg Tyr Phe Pro Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Thr Arg Arg Arg Val Phe Gln 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Glu Ile Leu Glu Glu Val Arg Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Arg Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Arg Arg Gln Asn Ile Arg Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Glu Thr Ser Asp Arg Leu Glu Glu Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Pro Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Arg Gly Gln Met Thr 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Trp Asp 
                405             


<210>  248
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  248

Met Trp Leu Arg His Gln Asn Asn Glu Pro Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Arg Ala Ala Gln 
            20                  25                  30          


Gln Thr Asn Thr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln His Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Glu Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Ser Thr Gly Leu Asp Glu Arg Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Gln Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Glu Gln Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Leu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Asp Tyr Arg Arg Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Thr Ser Pro Pro Arg Pro Asn Gln Thr 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu His Leu 
            180                 185                 190         


Arg Gln Tyr Phe Ser Asp Val Pro Asn Ile His Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Asn Phe Ser Tyr Arg Thr Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Glu Glu Ile Leu Arg Glu Val Arg Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Glu Asn Met Val Arg Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Gln Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg His Arg Ser Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Pro Gln Leu Glu Glu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Glu Asp Val Arg Arg Val Leu Glu 
            340                 345                 350         


Gln Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Asn Gly Arg Met Ser 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Ala Glu Ile Glu His Val Leu Arg 
385                 390                 395                 400 


Asp Tyr Trp Tyr Ala Ile Glu Leu 
                405             


<210>  249
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  249

Met Trp Leu Arg Lys Gln Asn Asn Glu Pro Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Leu Asp Leu Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Glu Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Ser Lys Gly Leu Asp Glu Arg Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Gln Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Pro Trp Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Thr Ala Pro Pro Val Pro Asn Thr Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Thr Leu 
            180                 185                 190         


Arg Arg Tyr Phe Ser Asp Val Pro Asn Ile Ala Arg Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Asn Phe Ser Tyr Arg Thr Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Arg Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg His Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Pro Gln Leu Glu Glu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Arg Leu 
                405             


<210>  250
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  250

Met Trp Glu Arg Lys Gln Asn Gly Glu Arg His Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Thr Arg His Glu Arg Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Arg Glu 
    50                  55                  60                  


Val Glu Arg Ile Ala Arg Glu Lys Gly Leu Asp Glu Arg Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Glu Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Tyr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Leu Pro Glu Val Leu Asp Trp Arg Glu Ile Ala Glu Arg Thr Arg Arg 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Arg Arg Thr Gln Gln Asn Thr Glu Phe 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Phe Pro Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Arg Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Ala Val Arg Gly Ile Leu Glu Glu Val Arg Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Glu Ile Pro Glu Arg Arg Arg Gln Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Trp Trp Arg Asn Tyr Tyr 
305                 310                 315                 320 


Asp Thr Ser Asp Arg His Arg Glu Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Glu 
            340                 345                 350         


Arg Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Ile Arg Arg Ile Tyr 
        355                 360                 365             


Glu Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Glu Gly Arg Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Glu Asn 
                405             


<210>  251
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  251

Met Trp Leu Arg Lys Gln Asn Asn Glu Pro Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Leu Asn Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Arg Ser Lys Gly Leu Asp Glu Arg Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Glu 
                85                  90                  95      


Pro Gln Ala Met His Tyr Ala Glu Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Asp Trp Arg Arg Ile Ala Glu Arg Thr Arg Arg 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Thr Ala Pro Pro Val Pro Asn Glu Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Thr Leu 
            180                 185                 190         


Arg Arg Tyr Phe Ser Asp Val Pro Asn Ile Ala Arg Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Asn Phe Ser Tyr Asp Arg Val Phe Gln 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Arg Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Glu Asn Met Val Arg Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg His Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Arg Val Leu Glu 
            340                 345                 350         


Leu Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Asn Gly Asn Met Ser 
    370                 375                 380                 


Asn Asp Pro Arg Asp Leu Ile Arg Lys Glu Ile Ala Leu Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Gln Leu 
                405             


<210>  252
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  252

Met Trp Leu Arg Lys Gln Tyr Asn Glu Pro Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Leu Asn Thr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Glu Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Ser Lys Gly Leu Asp Glu Arg Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ser 
                85                  90                  95      


Pro Gln Ala Met Glu Tyr Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Gln Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Pro Pro Val Pro Asn Thr Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Ser Leu 
            180                 185                 190         


Arg Lys Tyr Phe Ser Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Glu Asn Met Val Arg Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Gln Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg His Arg Ser Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Pro Gln Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Arg Val Leu Glu 
            340                 345                 350         


Ala Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Asp 
    370                 375                 380                 


Thr Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Leu Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  253
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  253

Met Trp Glu Arg Arg Gln Asn Gly Gln Lys Glu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Arg Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Arg His Ser Arg Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Glu 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Glu Lys Gly Leu Asp Glu Arg Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Ser 
                85                  90                  95      


Pro Glu Ala Met Asn Glu Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Glu Ala Glu Glu Arg Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Glu Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Tyr Leu 
            180                 185                 190         


Lys Arg Tyr Phe Pro Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Arg Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Gln Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Pro Glu Phe Ile Arg 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Asp Gly Arg Met Asp 
    370                 375                 380                 


Asn Asp Pro Arg Arg Leu Ile Glu Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile His Arg 
                405             


<210>  254
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  254

Met Trp Leu Glu Arg Glu Tyr Gly Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Thr Arg Gly Asp Arg Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Arg Asp Phe Arg Glu Glu 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Glu Lys Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Arg 
                85                  90                  95      


Pro Glu Ala Met Glu Glu Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Glu Pro Lys Val Leu Pro Tyr Glu Glu Ile Ala Glu Gln Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Ser Leu 
            180                 185                 190         


Glu Arg Tyr Phe Pro Asp Val Glu Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Thr Arg Asp Arg Val Phe Gln 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Gln Ile Pro Glu Arg Glu Arg Ser Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Thr Ser Lys Glu His Glu Arg Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Glu Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Glu Leu 
                405             


<210>  255
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  255

Met Trp Glu Ser Lys Arg His Gly Arg Glu His Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Trp Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Arg Lys Gly Tyr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Trp Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Glu Glu Ile Ala Lys Arg Lys Gly Leu Glu Pro Arg Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Glu 
                85                  90                  95      


Pro Thr Ala Met Gln Lys Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Asp Val Leu Pro Asp Glu Glu Ile Ala Arg Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Tyr Arg Gln Gln Phe Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Arg Ala Ile Glu Ala Leu 
            180                 185                 190         


Lys Arg Tyr Phe Pro Asp Val Pro Asn Ile Leu Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Arg Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Arg Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Arg Arg Gln Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Glu Thr Ser Asp Gln Leu Arg Glu Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Glu 
            340                 345                 350         


Arg Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Glu Arg Tyr Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Gln Asp Val Arg Asp Gly Arg Met Thr 
    370                 375                 380                 


Asn Asp Pro Arg Arg Leu Ile Leu Lys Glu Ile Gln Leu Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Tyr Asp 
                405             


<210>  256
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  256

Met Trp Leu Arg Lys Arg Asn Gly Glu Pro Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Arg Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Gln Tyr Asn Arg Glu Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Arg Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Glu Glu Ile Ala Lys Ser Lys Gly Leu Glu Pro Arg Arg Ile Leu 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Glu 
                85                  90                  95      


Pro Thr Ala Met Gln Lys Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Asp Trp Arg Glu Ile Ala Arg Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Thr Ala Arg Thr Tyr Pro Asn Glu Phe 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Arg Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Phe Gln Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Thr Phe Ser Tyr Gln Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Asn Val Arg Glu Ile Leu Glu Glu Val Arg Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg His Arg Ser Asn Ile Arg Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Glu Glu Leu Arg Arg Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Glu Arg Val Leu Gln 
            340                 345                 350         


Gln Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Arg Lys Glu Ile Arg Ile Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Glu Leu 
                405             


<210>  257
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  257

Met Trp Glu Glu His Asp His Asn Gln Pro Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Arg Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


His Arg His Glu Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln His Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Arg Gln Gln Gly Leu Asp Glu Arg Gln Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Glu Glu Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr His Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Glu Ile Ala Arg Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Arg Glu Thr Ala Arg Glu Glu Glu Phe Gly Ser 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu His Leu 
            180                 185                 190         


Arg Gln Tyr Phe Gln Asp Val Pro Glu Ile Trp Arg Leu Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Thr Arg Asp Gln Val Phe Gln 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Glu Ile Leu Glu Glu Val Lys Arg Asn 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Arg Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Glu Asp Val Glu Arg Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Asp Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Glu Ser Tyr Glu Asp Val Arg Arg Gly Arg Met Asp 
    370                 375                 380                 


Thr Asp Pro Arg Glu Leu Ile Lys His Glu Ile Lys Arg Val Leu Arg 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Gln Arg 
                405             


<210>  258
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  258

Met Trp Glu Ser Lys Arg His Asn Glu Pro Arg Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Trp Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Arg Gln Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Gln Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Arg Arg Lys Gly Leu Asp Glu Arg Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Glu 
                85                  90                  95      


Pro Arg Ala Met Glu Tyr Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Ile Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Asp Arg Leu Pro Leu Glu Glu Ile Ala Arg Leu Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Tyr Ala Gln Glu Phe Asp Arg Glu Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Ala Leu 
            180                 185                 190         


Glu Arg Tyr Phe Asp Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Thr Tyr Asp Gln Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Glu Glu Ile Leu Arg Glu Val Gln Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Glu Glu Ile Ile Pro Glu Arg Glu Arg Gln Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Glu Asp Val Arg Arg Val Leu Glu 
            340                 345                 350         


Leu Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Glu Arg Tyr Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Arg Gly Arg Met Glu 
    370                 375                 380                 


Pro Asp Pro Arg Arg Leu Ile His Lys Glu Ile Ile Leu Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Leu Thr 
                405             


<210>  259
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  259

Met Trp Leu Gln Gln Arg Asn Gly Gln Lys Trp Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Arg Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Ser Asn Thr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Gln Ile Ala Arg Glu His Gly Leu Asp Glu Arg Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Asn Arg Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Asp Tyr Arg Glu Ile Ala Arg Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Glu Ala Glu Glu Gln Ser Ser Thr Asp Pro Asn Glu Thr 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Arg Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Glu Leu 
            180                 185                 190         


Arg Arg Gln Phe Gln Asp Val Pro Asn Ile His Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Thr Phe Ser Arg Arg Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Glu Asp Ser Glu Gln Leu Arg Glu Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Arg Arg Glu Ile Lys Glu Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Glu Leu 
                405             


<210>  260
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  260

Met Trp Glu Glu His Asp His Leu Thr Lys Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Gln Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln His Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Arg Arg Lys Gly Leu Asp Glu Arg Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Glu Gln Ala Lys Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Tyr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Lys Val Leu Pro Tyr Glu Glu Ile Ala Arg Gln Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Gln Gln Glu Thr Asp Arg Glu Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu His Leu 
            180                 185                 190         


Glu Arg Tyr Phe Asp Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Thr Tyr Arg Thr Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser His Ile 
        275                 280                 285             


Glu Gln Glu Ile Ile Pro Glu Arg Glu Arg Gln Asp Ile Gln Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Gln Leu Glu Glu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Glu Asp Val Arg Arg Val Leu Glu 
            340                 345                 350         


His Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Arg Gly Arg Met Glu 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Arg 
                405             


<210>  261
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  261

Met Trp Leu Glu Arg His Tyr Asn Leu Pro Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Asn Arg His Glu Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Thr Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Tyr Lys Ile Ala Lys Glu Lys Gly Leu Asp Leu Arg Asp Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ala 
                85                  90                  95      


Pro Glu Ala Met Ser Arg Ala Glu Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Glu Val Leu His Trp Trp Glu Ile Ala Leu Leu Thr Arg Asp 
    130                 135                 140                 


Leu Phe Ala Val Ala Glu Glu Val Ala Arg Lys Phe Asn Phe Gln Leu 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Tyr Tyr Leu 
            180                 185                 190         


Lys Glu Ala Phe Arg Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Arg Val Glu Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Arg Arg Ser Glu Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Lys Arg Leu Glu Trp Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Arg Val Leu Glu 
            340                 345                 350         


Arg Leu Phe Arg Asn Phe Ser Glu Pro Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Asp Gly Arg Met Glu 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Asp Leu 
                405             


<210>  262
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  262

Met Trp Glu Glu Lys Glu Tyr Gly Gln Glu Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Glu Gln Gly Tyr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Trp Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Glu Glu Ile Ala Arg Arg Lys Gly Leu Asp Glu Arg Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Arg Glu Ala Glu Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Leu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Trp Pro Asp Glu Leu Pro Arg Glu Trp Ile Ala Arg Trp Thr Arg Arg 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Tyr Arg Gln Thr Phe Asn Thr Glu Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Tyr Leu 
            180                 185                 190         


Arg Arg Tyr Phe Pro Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Thr Arg Arg Arg Val Phe Gln 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Arg Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Arg Arg Gln Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Glu Thr Ser Lys Arg Leu Glu Glu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Gln Tyr Glu Asp Val Arg Arg Val Leu Glu 
            340                 345                 350         


Glu Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Glu Arg Tyr Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Gln Asp Val Arg Asp Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Trp Arg 
                405             


<210>  263
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  263

Met Trp Leu Pro His His Tyr Gly Arg Pro Phe Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Trp Val Ile Glu Ala Ser Ile Arg Phe Ala Met 
            20                  25                  30          


Arg Leu His Tyr Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Trp Thr Pro Thr Asp Phe Ala Asn Phe 
    50                  55                  60                  


Val Tyr Glu Ile Ala Arg Arg Leu Gly Leu Ser Glu Ser Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Glu 
                85                  90                  95      


Pro Val Ala Met Asn Glu Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Trp Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Trp Ser Glu Thr Leu His Trp Gln Val Ile Ala Asp Trp Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Glu Ala Glu Glu Gln Ala Arg Gly Phe Asn Phe Trp Pro 
145                 150                 155                 160 


Ile Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Arg Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Tyr Leu 
            180                 185                 190         


Arg Arg Tyr Phe Asn Asp Val Arg Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Arg Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Glu Pro Ile Leu Arg Glu Val Ser Arg Tyr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Asp Arg Ile Ile Pro Glu Arg Arg Arg Ser Glu Ile Met Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Glu Thr Gly Pro Gln Leu Glu Trp Asp Ile Phe Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Pro Val Pro Pro Asp Phe Ile Arg 
        355                 360                 365             


Asp His Phe Tyr Glu Ser Trp Arg Asp Val Arg Asp Gly Arg Met Arg 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Tyr His Glu Ile Glu Leu Val Leu Arg 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Leu Asp 
                405             


<210>  264
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  264

Met Trp Leu Arg Lys Gln Asn Asn Glu Lys Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Arg Leu Asn Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Phe Gln Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Glu Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Ser Lys Gly Leu Asp Glu Arg Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Arg 
                85                  90                  95      


Pro Gln Ala Met Glu Tyr Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Asp Trp Arg Ile Ile Ala Glu Trp Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Thr Ser Pro Pro Val Pro Asn Glu Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Thr Leu 
            180                 185                 190         


Arg Glu Tyr Phe Ser Asp Val Pro Asn Ile Tyr Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Asn Phe Ser Tyr Thr Glu Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Gln Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg His Arg Ser Asn Ile Gln Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Arg Asp Asp His Gln Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Glu Asp Val Arg Arg Val Leu Glu 
            340                 345                 350         


Leu Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Asn Gly Asn Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Met Leu Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Gln Leu 
                405             


<210>  265
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  265

Met Trp Leu Arg His Gln Asn Asn Glu Pro Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Arg His Ala Gln 
            20                  25                  30          


Arg His Asn Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln His Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Glu Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Ser Thr Gly Leu Asp Glu Arg Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Gln Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Asn Gln Ala Glu Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Gln Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Asp Tyr Arg Arg Ile Ala Glu Arg Thr Arg Arg 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Arg Thr Ser Pro Pro Gln Pro Asn Gln Thr 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Ser Leu 
            180                 185                 190         


Glu Arg Tyr Phe Glu Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Asn Phe Ser Tyr Asp Arg Val Phe Gln 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Arg Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Glu Asn Met Val Arg Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg His Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Glu Asp Val Glu Arg Val Leu Arg 
            340                 345                 350         


Gln Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Arg Val Arg Asn Gly Glu Met Asp 
    370                 375                 380                 


Thr Asp Pro Arg Glu Leu Ile Leu Ala Glu Ile Glu Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Gln Leu 
                405             


<210>  266
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  266

Met Trp Glu Glu His Asp Tyr Leu Gln Lys Phe Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Gln Gly Thr Glu Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Glu Glu Ile Ala Arg Arg Lys Gly Leu Asp Glu Asp Lys Ile Arg 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Gln Pro Glu 
                85                  90                  95      


Pro Thr Ala Met Glu Glu Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Asp Glu Leu Pro Arg Glu Glu Ile Ala Arg Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Asp Ala Glu Arg His Ala Gln Lys Tyr Pro Glu Glu Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Arg Leu 
            180                 185                 190         


Lys Glu Tyr Phe Pro Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Arg Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Arg Arg Gln Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Glu Thr Ser Asp Gln Leu Arg Glu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Gln Tyr Asp Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile His Arg 
                405             


<210>  267
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  267

Met Trp Leu Arg His Glu Tyr Gly Gln Pro Glu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Arg Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Arg Lys His Glu Arg Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Glu 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Glu Glu Gly Leu Asp Glu Arg Gln Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Arg 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Glu Pro Lys Val Leu Asp Tyr Arg Glu Ile Ala Glu Gln Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Arg Thr Glu Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Glu Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu His Leu 
            180                 185                 190         


Glu Arg His Phe Pro Asp Val Glu Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Thr Arg Asp Arg Val Phe Gln 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Gln Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asn Tyr Tyr 
305                 310                 315                 320 


Asp Thr Ser Lys Arg His Glu Glu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Glu Gly Arg Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Arg Leu Ile His His Glu Ile Glu Arg Val Leu Arg 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Glu Arg 
                405             


<210>  268
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  268

Met Trp Leu Met Val Gln Asn Asn Ile Pro Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Glu Lys Asn Ser Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Arg Ser Lys Gly Leu Glu Glu Asp Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Ser Lys Ala Gln Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Leu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Glu Thr Leu Asp Trp Arg Glu Ile Ala Ile Leu Thr Arg Ile 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Arg Val Ala Pro Pro Val Pro Asn Leu Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Trp Leu 
            180                 185                 190         


Tyr Arg Tyr Phe Ser Asp Val Pro Asn Ile Ala Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg His Arg Ser Asp Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Pro Ala Leu Glu Asp Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Arg Val Leu Glu 
            340                 345                 350         


Leu Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Leu Leu 
                405             


<210>  269
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  269

Met Trp Leu Ser Lys Gln Tyr Asn Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Leu Asp Gln Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Asp Glu Arg Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Glu 
                85                  90                  95      


Pro Thr Ala Met Glu Lys Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Lys Val Leu Asp Trp Arg Glu Ile Ala Arg Leu Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Thr Ala Pro Glu Val Pro Asn Glu Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Thr Leu 
            180                 185                 190         


Lys Arg Tyr Phe Ser Asp Val Pro Asn Ile Ala Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Glu Glu Ile Leu Arg Glu Val Glu Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Pro Gln Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Glu Arg Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Glu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Arg Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  270
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  270

Met Trp Leu Ser Lys Asp Tyr Asn Glu Pro Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


His Ile His Glu Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Lys Gly Leu Asp Glu Arg Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Gln Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Ile Ala Glu Glu Thr Ala Gln Asp Phe Pro Phe Leu Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Ser Leu 
            180                 185                 190         


Arg Lys Tyr Phe Arg Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Arg Glu Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Met 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Glu Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Asp Glu Leu Glu Glu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Glu Asp Val Glu Arg Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Pro Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Asp Gly Arg Met Glu 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Phe Thr 
                405             


<210>  271
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  271

Met Trp Leu Arg Lys Asp Asn Asn Glu Pro Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Leu Ser Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Phe Gln Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Glu Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Ser Lys Gly Leu Glu Glu Asp Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Glu 
                85                  90                  95      


Pro Gln Ala Met Glu Tyr Ala Lys Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Glu Thr Leu Asp Tyr Arg Glu Ile Ala Arg Leu Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ser Pro Pro Gln Pro Asn Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Ser Leu 
            180                 185                 190         


Arg Lys Tyr Phe Ser Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Gln Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Gln Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Pro Gln Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Glu Arg Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Pro Arg Tyr Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Ala Phe Asp Val Arg Asn Gly Asn Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Gln Leu 
                405             


<210>  272
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  272

Met Trp Leu Arg Lys Gln Asn Asn Glu Pro Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Arg Thr Asn Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Glu Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Ser Lys Gly Leu Asp Glu Arg Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Glu 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Gln Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Lys Val Leu Asp Tyr Arg Glu Ile Ala Arg Leu Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Pro Pro Val Pro Asn Thr Ile 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Ser Leu 
            180                 185                 190         


Arg Glu Tyr Phe Glu Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Gln Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Glu Arg Ser Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Pro Gln Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Met Leu Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Leu Tyr Ala Ile Gln Leu 
                405             


<210>  273
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  273

Met Trp Leu Glu Lys His Tyr Gly Arg Glu Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Trp Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Gln Leu His Asn Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Trp Ser Gly Gly Tyr Ser Gly Trp Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Glu Glu Ile Ala Arg Arg Lys Gly Leu Asp Glu Arg Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Glu 
                85                  90                  95      


Pro Gln Ala Met Gln Tyr Ala Gln Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Glu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Asp Trp Arg Arg Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Ile Ala Glu Glu Thr Ala Ser Gly Phe Pro Phe Arg Pro 
145                 150                 155                 160 


Ile Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Arg Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Tyr Leu 
            180                 185                 190         


Arg Gln Tyr Phe Asn Asp Val Arg Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Arg Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Arg Arg Tyr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Gln Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Glu Glu Ile Ile Pro Glu Arg Arg Arg Ser Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Glu Thr Ser Asp Gln Leu Arg Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Pro Val Asp Pro Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Arg Ser Tyr Glu Asp Val Arg Asp Gly Arg Met Gln 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Arg Lys Glu Ile Arg Leu Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Asp 
                405             


<210>  274
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  274

Met Trp Leu Arg His Gln Tyr Asn Glu Lys Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu His Ala Gln 
            20                  25                  30          


Glu His Asn Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln His Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Arg Ser Lys Gly Leu Asp Glu Arg Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Gln Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Glu Gln Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Asp Tyr Arg Arg Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ser Pro Pro Gln Pro Asn Glu Thr 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Ser Leu 
            180                 185                 190         


Arg Lys Tyr Phe Ser Asp Val Pro Asn Ile His Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Gln Ile 
        275                 280                 285             


Glu Gln Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Pro Gln Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Glu Asp Val Glu Arg Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Gln Leu 
                405             


<210>  275
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  275

Met Trp Leu Arg Lys Gln Asn Asn Glu Lys Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Tyr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Glu Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Ser Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ser 
                85                  90                  95      


Pro Gln Ala Met Glu Tyr Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Arg Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ser Pro Pro Val Pro Asn Glu Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Thr Leu 
            180                 185                 190         


Arg Gln Tyr Phe Glu Asp Val Pro Asn Ile Tyr Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Gln Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Gln Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Pro Gln Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Glu Leu 
                405             


<210>  276
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  276

Met Trp Leu Asp His His Tyr Gly Arg Pro Phe Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Ala Ala Met 
            20                  25                  30          


Asn Gln His Tyr Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Trp Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Glu Lys Ile Ala Lys Glu Lys Gly Leu Ser Leu Ser Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Tyr Pro Ser 
                85                  90                  95      


Pro Trp Ala Met Asn Glu Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Ser Glu Thr Leu Pro Trp Arg Lys Ile Ala Glu Trp Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Glu Ala Glu Glu Gln Ala Arg Gly Phe Pro Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Arg Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Glu Leu 
            180                 185                 190         


Arg Glu Tyr Phe Arg Asp Val Leu Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Arg Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Glu Pro Ile Leu Arg Glu Val Trp Arg Tyr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Arg Arg Ser Glu Ile Pro Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Glu Thr Ser Asp Gln Leu Arg Trp Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Arg Val Leu Glu 
            340                 345                 350         


Gln Leu Phe Arg Asn Phe Ser Glu Pro Val Pro Pro Glu Phe Ile Arg 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Trp Glu Asp Val Arg Asp Gly Arg Met Arg 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Trp Tyr Ala Ile Leu Asp 
                405             


<210>  277
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  277

Met Trp Glu Arg His Glu Tyr Gly Gln Ala Phe Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Thr Arg His Glu Arg Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Arg Asp Glu 
    50                  55                  60                  


Val Phe Arg Ile Ala Arg Glu Lys Gly Leu Asp Glu Arg Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Tyr Pro Arg 
                85                  90                  95      


Pro Trp Ala Met Asn Glu Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Tyr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Glu Pro Glu Val Leu Pro Trp Pro Glu Ile Ala Glu Arg Thr Arg Asp 
    130                 135                 140                 


Leu Phe Glu Glu Ala Glu Arg Arg Arg Thr Gln Phe Asn Thr Glu Pro 
145                 150                 155                 160 


Trp Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Arg Ala Ile Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Phe Pro Asp Val Met Asn Ile Tyr Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Thr Arg Asp Arg Val Phe Tyr 
    210                 215                 220                 


Tyr Asp Arg Asp Ala Val Arg Pro Ile Leu Trp Glu Val Ser Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Arg Arg Gln Glu Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Trp Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Thr Ser Trp Trp His Glu Trp Asp Ile Phe Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Glu 
            340                 345                 350         


Arg Leu Phe Arg Asn Phe Ser Glu Gly Val His Pro Glu Phe Ile Arg 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Asn Gly Arg Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Tyr Tyr Ala Ile Phe Trp 
                405             


<210>  278
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  278

Met Trp Leu Arg Phe His Tyr Asn Glu Pro Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


His Ile His Tyr Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Thr Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Glu Lys Gly Leu Asp Glu Arg Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ala 
                85                  90                  95      


Pro Gln Ala Met Thr Tyr Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Leu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu His Trp Glu Glu Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Leu 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Tyr Tyr Leu 
            180                 185                 190         


Lys Glu Tyr Phe Arg Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Asp Val Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Glu Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Arg Arg Ser Gln Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Ile Trp Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Tyr Tyr Val Leu Leu 
            340                 345                 350         


Leu Leu Phe Trp Asn Phe Ser Glu Pro Val Pro Leu Glu His Ile Arg 
        355                 360                 365             


Asp Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Asp Gly Arg Met Ser 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Trp Thr 
                405             


<210>  279
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  279

Met Trp Glu Leu His Asp Asn Gly Gln Arg Phe Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Asn Arg His Trp Arg Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Glu 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Glu Lys Gly Leu Glu Glu Asn Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Tyr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Glu Pro Glu Val Leu Pro Trp Pro Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Arg Thr Gln Gln Asn Thr Glu Phe 
145                 150                 155                 160 


Trp Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Trp Leu 
            180                 185                 190         


Lys Arg Tyr Phe Pro Asp Val Pro Asn Ile Leu Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Thr Arg Asp Thr Val Phe Tyr 
    210                 215                 220                 


Tyr Asp Arg Asp Ala Val Arg Pro Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Arg Arg Gln Glu Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Ser Thr Ser Lys Ser His Glu Trp Asp Ile Phe Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val His Pro Ser Phe Ile Arg 
        355                 360                 365             


Asp Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Glu Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Trp Tyr Ala Ile Tyr Trp 
                405             


<210>  280
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  280

Met Trp Glu Glu Lys Asp Tyr Gly Gln Arg Arg Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Arg Gly Glu Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln His Gly Gly Tyr Ser Gly Trp Thr Pro Glu Asp Phe Arg Gln Phe 
    50                  55                  60                  


Val Glu Glu Ile Ala Arg Arg Lys Gly Leu Asp Pro Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Arg Glu Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Ser Val Leu Pro Tyr Gln Glu Ile Ala Arg Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Ala Glu Thr Ala Arg Asp Gln Glu Phe Gly Arg 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Tyr Leu 
            180                 185                 190         


Arg Arg Tyr Phe Ser Asp Val Pro Arg Ile Trp Asp Gln Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Arg Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Arg Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Glu Asp Ser Lys Arg His Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Tyr Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Arg 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Asn Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Trp Tyr Ala Ile Asn Arg 
                405             


<210>  281
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  281

Met Trp Leu Glu His His Tyr Gly Gln Lys Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Gln Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Gln His His Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Glu Glu Ile Ala Arg Arg Lys Gly Leu Asp Glu Arg Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Ser 
                85                  90                  95      


Pro Glu Ala Met Glu Glu Ala Arg Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Ser Glu Thr Leu Pro Tyr Arg Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Glu Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Arg Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Tyr Leu 
            180                 185                 190         


Lys Glu Tyr Phe Arg Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Arg Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Arg Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Glu Thr Ser Asp Gln Leu Arg Glu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Gln Tyr Pro Asp Val Gln Glu Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Pro Val Asp Glu Glu Phe Ile Arg 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Arg 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  282
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  282

Met Trp Leu Leu His Gln Tyr Gly Gln Arg Phe Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Trp Val Ile Arg Ala Ser Ile Gln Phe Ala Ile 
            20                  25                  30          


Thr Arg His His Arg Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Glu 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Glu Glu Gly Leu Glu Glu Asn Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Tyr Pro Arg 
                85                  90                  95      


Pro Trp Ala Met Glu Glu Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Tyr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Leu Pro Glu Val Leu His Trp Ser Glu Ile Ala Glu Gln Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Arg Thr Gln Gln Asn Thr Glu Phe 
145                 150                 155                 160 


Tyr Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Gln Leu 
            180                 185                 190         


Arg Arg His Phe Pro Asp Val Met Asn Ile Tyr Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Arg Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Ala Val Arg Pro Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Gln Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Thr Ser Lys Asp His Glu Trp Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val His Pro Ser Phe Ile Arg 
        355                 360                 365             


Asp Tyr Phe Tyr Arg Ser Tyr Glu Asp Val Arg Glu Gly Arg Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Phe Arg Glu Ile Arg Glu Val Leu Gln 
385                 390                 395                 400 


Asp Tyr Tyr Tyr Ala Ile Phe Trp 
                405             


<210>  283
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  283

Met Trp Leu Arg Lys His Tyr Asn Glu Pro Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


His Arg Gly Glu Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Asp Tyr Pro Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Arg Arg Glu 
225                 230                 235                 240 


Pro Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Gln Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Glu Asp Val Glu Arg Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Pro Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Glu 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Asp Thr 
                405             


<210>  284
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  284

Met Trp Leu Asp Ala His Tyr Gly Arg Pro Phe Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Trp Val Ile Arg Ala Ser Ile Arg Phe Ala Lys 
            20                  25                  30          


Arg Leu His Tyr Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Glu Leu Gly Leu Glu Glu Asn Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Tyr Pro Ser 
                85                  90                  95      


Pro Trp Ala Met Gln Glu Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Trp Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Ser Glu Thr Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Gly Phe Asn Phe Trp Pro 
145                 150                 155                 160 


Ile Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Arg Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Arg Arg Ser Arg Ile Arg Asp Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Glu Thr Ser Asp Gln Leu Arg Tyr Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Glu Glu Val Leu Arg 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Pro Val Pro Pro Glu Phe Ile Arg 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Asp Gly Arg Met Gln 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Phe His Glu Ile Glu Leu Val Leu Arg 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Leu Asp 
                405             


<210>  285
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  285

Met Trp Leu Arg His Gln Asn Asn Glu Pro Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Arg Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Thr Asn Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Arg Gln Thr Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Glu Lys Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Glu Thr Leu Pro Tyr Glu Lys Ile Ala Glu Gln Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Thr Ser Pro Pro Gln Pro Asn Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Glu Asn Met Val Arg Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Gln Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg His Arg Ser Asn Ile Gln Glu Val 
    290                 295                 300                 


Ile Leu Gln Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Pro Gln Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Glu Asp Val Arg Arg Val Leu Glu 
            340                 345                 350         


Gln Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Asn Gly Asn Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Arg Tyr Ala Ile Gln Leu 
                405             


<210>  286
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  286

Met Trp Glu Gln His Arg Tyr Asn Arg Lys Tyr Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Lys Gly Thr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Asp Glu Arg Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Tyr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Asp Arg Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Gln Gln Glu Thr Asp Arg Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Glu Lys Tyr Phe Asp Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Arg Val Arg Glu Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Gln Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Arg Val Leu Glu 
            340                 345                 350         


Arg Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Arg Gly Arg Met Glu 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  287
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  287

Met Trp Leu Leu Val Gln Trp Asn Ile Lys Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Trp Val Ile Ile Ala Ser Ile Leu Thr Ala Met 
            20                  25                  30          


Glu Phe Asn Tyr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Tyr Glu Ile Ala Leu Gln Leu Gly Leu Glu Leu Asp Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ala 
                85                  90                  95      


Pro Arg Ala Met Thr Tyr Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Leu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Glu Thr Leu Asp Trp Arg Gln Ile Ala Ile Tyr Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Arg Val Ala Pro Pro Val Pro Asn Leu Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Thr Leu 
            180                 185                 190         


Leu Arg Tyr Phe Ser Asp Val Pro Asn Ile Ala Ser Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Leu Pro Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg His Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Pro Ala Leu Glu Asp Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Arg Val Leu Glu 
            340                 345                 350         


Leu Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Ala Val Arg Glu Gly Lys Met Ser 
    370                 375                 380                 


Asn Asp Pro Arg Asp Leu Ile Leu Trp Glu Ile Lys Leu Val Leu Leu 
385                 390                 395                 400 


Asp Tyr Trp Tyr Ala Ile Ile Leu 
                405             


<210>  288
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  288

Met Trp Leu Arg Lys His Tyr Gly Glu Pro Gln Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Glu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Gly Phe Pro Phe Arg Pro 
145                 150                 155                 160 


Ile Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Arg Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Arg Asp Arg Ile Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Glu Arg Ser Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Glu Asp Ser Lys Gln Leu Glu Leu Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Pro Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Asp Gly Arg Met Arg 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Asn 
                405             


<210>  289
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  289

Met Trp Leu Met Val Gln Asn Asn Leu Pro Tyr Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Ala Ala Lys 
            20                  25                  30          


Glu Tyr Asn Phe Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Glu Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Arg Ser Lys Gly Leu Glu Glu Asp Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Glu Thr Leu Asp Tyr Arg Ile Ile Ala Ile Tyr Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Pro Pro Val Pro Asn Gln Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg His Arg Ser Asp Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Pro Ala Leu Glu Leu Asp Ile Phe Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Met Tyr Pro Asp Val Trp Thr Val Leu Met 
            340                 345                 350         


Leu Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Glu Arg Phe Ile Tyr 
        355                 360                 365             


Leu Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Trp Tyr Ala Ile Ile Leu 
                405             


<210>  290
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  290

Met Trp Leu Leu Val Gln Trp Asn Ile Pro Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Ala Ala Met 
            20                  25                  30          


Glu Thr Asp Gln Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Arg Ser Lys Gly Leu Glu Glu Asp Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Gln Pro Glu Thr Leu Asp Tyr Arg Gln Ile Ala Ile Tyr Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Pro Pro Val Pro Asn Gln Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Leu Lys Tyr Phe Ser Asp Val Pro Asn Ile Ala Asn Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Glu Glu Ile Leu Arg Glu Val Ser Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Glu Arg Ser Asp Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Pro Ala Leu Glu Leu Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Leu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Trp Tyr Ala Ile Leu Leu 
                405             


<210>  291
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  291

Met Trp Leu Arg Lys Gln Tyr Gly His Lys Glu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Arg Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Leu His Ser Arg Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Leu 
    50                  55                  60                  


Val Met Glu Ile Ala Arg Arg Lys Gly Leu Asp Glu Arg Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Gln Lys Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Tyr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Glu Pro Glu Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Gln 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Tyr Arg Arg Lys Tyr Asn Thr Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Ser Leu 
            180                 185                 190         


Arg Arg Tyr Phe Pro Asp Val Pro Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Arg Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Glu Arg Ser Asp Ile Arg Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Thr Ser Lys Glu His Glu Arg Asp Ile Glu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Tyr Tyr Pro Asp Val Glu Arg Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asn Ser Tyr Glu Asp Val Arg Glu Gly Arg Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Ser Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile His Arg 
                405             


<210>  292
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  292

Met Trp Leu Glu Leu Leu Trp Asn Gln Pro Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Thr Ala Lys 
            20                  25                  30          


Glu Lys Gly Trp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Phe Gln Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Tyr Gln Ile Ala Lys Glu Lys Gly Leu Glu Leu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ala 
                85                  90                  95      


Pro Gln Ala Met Glu Tyr Ala Lys Ile Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Leu Lys Ile His Ile Asp Cys Ser Met Ala Leu Ser Asp 
        115                 120                 125             


Gln Pro Tyr Tyr Leu Asp Tyr Arg Gln Ile Ala Ile Tyr Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Pro Pro Val Pro Asn Leu Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Thr Leu 
            180                 185                 190         


Lys Arg Tyr Phe Ser Asp Val Pro Asn Ile Phe Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Glu Arg Ser Asp Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Glu Arg Tyr Ile Tyr 
        355                 360                 365             


Leu Tyr Phe Tyr Asp Ser Tyr Phe Ala Val Arg Arg Gly Glu Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Trp Glu Ile Ile Leu Val Leu Tyr 
385                 390                 395                 400 


Asp Tyr Trp Tyr Ala Ile Ile Leu 
                405             


<210>  293
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  293

Met Trp Leu Met Val Gln Tyr Asn Leu Pro Tyr Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Ala Ala Lys 
            20                  25                  30          


Glu Tyr Asn Phe Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Asp Ser Lys Gly Leu Glu Arg Asp Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Trp Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Pro Pro Val Pro Asn Gln Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Thr Leu 
            180                 185                 190         


Tyr Arg Tyr Phe Ser Asp Val Pro Asn Ile Ala Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Glu Arg Ser Asp Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Glu Asp Val Ala Arg Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Leu Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Trp Tyr Ala Ile Ile Leu 
                405             


<210>  294
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  294

Met Trp Leu Met Leu Gln Tyr Leu Ile Asn Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Ala Ala Gln 
            20                  25                  30          


Glu Tyr Asp Leu Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Asp Arg Lys Gly Leu Glu Arg Asn Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Ala Lys Ala Glu Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Pro Leu Glu Val Ile Ala Glu Arg Thr Arg Arg 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Arg Thr Ala Arg Glu Tyr Asn Asn Gln Glu 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Asp Thr Leu 
            180                 185                 190         


Arg Arg Tyr Phe Glu Asp Val Pro Asn Ile Tyr Asn Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Phe Ile 
        275                 280                 285             


Glu Gln Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Glu Thr Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Pro Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Arg Gly Leu Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Phe Tyr Ala Ile Ile Leu 
                405             


<210>  295
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  295

Met Trp Leu Glu Lys His Tyr Gly Arg Lys His Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Met 
            20                  25                  30          


Gln Lys Asp Glu Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Phe Ser Gly Gly Tyr Ser Gly Trp Thr Pro Glu Asp Phe Arg Arg Phe 
    50                  55                  60                  


Val Glu Glu Ile Ala Arg Arg Lys Gly Leu Asp Pro Asp Lys Ile Gln 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Tyr Pro Glu 
                85                  90                  95      


Pro Gln Ala Met Gln Trp Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Glu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Trp Pro Lys Val Leu Pro Tyr Glu Val Ile Ala Glu Trp Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Ile Ala Glu Glu Thr Ala Arg Lys Phe Asn Phe Arg Pro 
145                 150                 155                 160 


Ile Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Arg Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Leu Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Arg Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Glu Ile Leu Glu Glu Val Arg Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Glu Thr Ser Asp Gln Leu Arg Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Pro Val Asp Ile Arg Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Arg Gly Gln Met Arg 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile His Asp 
                405             


<210>  296
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  296

Met Trp Leu Met Leu Gln Tyr Leu Ile Asn Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu His Ala Gln 
            20                  25                  30          


Glu Thr Asn Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Lys Glu Lys Gly Leu Glu Glu Asn Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Glu Lys Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Pro Leu Glu Val Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Arg Thr Ala Arg Glu Tyr Asn Asn Gln Glu 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Thr Leu 
            180                 185                 190         


Arg Asp Tyr Phe Ser Asp Val Pro Asn Ile Tyr Asn Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Asp Gln Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Glu Glu Ile Leu Arg Glu Val Ser Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Leu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Glu Glu Val Leu Arg 
            340                 345                 350         


Gln Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Pro Arg Tyr Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Thr Tyr Ala Ile Gln Leu 
                405             


<210>  297
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  297

Met Trp Leu Met Val Gln Tyr Asn Leu Pro Tyr Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Trp Val Ile Glu Ala Ser Ile Glu Thr Ala Lys 
            20                  25                  30          


Gln Tyr Asn Phe Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Arg Gln Lys Gly Leu Asp Glu Arg Met Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ser 
                85                  90                  95      


Pro Gln Ala Met Glu Tyr Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Leu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Trp Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Glu Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Thr Leu 
            180                 185                 190         


Leu Ala Tyr Phe Ser Asp Val Pro Asn Ile Ala Arg Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Glu Arg Ser Asp Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Pro Ala Leu Glu Leu Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Glu Arg Tyr Ile Tyr 
        355                 360                 365             


Leu Tyr Phe Tyr Asp Ser Tyr Phe Ala Val Arg Glu Gly Lys Met Ser 
    370                 375                 380                 


Asn Asp Pro Arg Asp Leu Ile Leu Trp Glu Ile Ile Leu Val Leu Tyr 
385                 390                 395                 400 


Asp Tyr Trp Tyr Ala Ile Ile Leu 
                405             


<210>  298
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  298

Met Trp Leu Met His Glu Tyr Gly Arg Lys Phe Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Asn Arg His His Arg Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Asp Glu Arg Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Arg 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Tyr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Glu Pro Lys Val Leu His Trp Ser Arg Ile Ala Glu Asp Thr Arg Asp 
    130                 135                 140                 


Leu Phe Glu Glu Ala Glu Arg Arg Ala Arg Lys Glu Asn Thr Gln Phe 
145                 150                 155                 160 


Glu Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Gln Ala Ile Glu Gln Leu 
            180                 185                 190         


Ile Arg His Phe Pro Asp Val Leu Asn Ile Leu Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Thr Arg Asp Thr Val Phe Tyr 
    210                 215                 220                 


Tyr Asp Arg Asp Ala Val Arg Pro Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Gln Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Ser Thr Ser Lys Ser His Glu Trp Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Tyr Tyr Pro Asp Val Glu Trp Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val His Pro Ser Phe Ile Arg 
        355                 360                 365             


Asp Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Glu Gly Arg Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Tyr Tyr Ala Ile Phe Leu 
                405             


<210>  299
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  299

Met Trp Glu Arg His Asp Asn Leu Gln Lys Phe Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Trp Val Ile Arg Ala Ser Ile Arg Phe Ala Lys 
            20                  25                  30          


Thr Arg Gly Glu Arg Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


His Arg Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Arg Asp Glu 
    50                  55                  60                  


Val Tyr Arg Ile Ala Arg Glu Glu Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Tyr Pro Ser 
                85                  90                  95      


Pro Trp Ala Met Glu Glu Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Tyr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Glu Pro Glu Val Leu Pro Trp Pro Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Arg Thr Gln Phe Asn Thr Glu Phe 
145                 150                 155                 160 


Trp Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Trp Leu 
            180                 185                 190         


Lys Arg Tyr Phe Pro Asp Val Pro Asn Ile Leu Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Thr Arg Asp Thr Val Phe Tyr 
    210                 215                 220                 


Tyr Asp Arg Asp Ala Val Arg Pro Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Phe Glu Gln Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Ser Thr Ser Lys Ser His Glu Trp Asp Ile Phe Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val His Pro Ser Phe Ile Leu 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile His Lys Glu Ile Met Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Tyr Tyr Ala Ile Phe Trp 
                405             


<210>  300
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  300

Met Trp Leu Asp Gln Arg Asn Gly Gln Pro Trp Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Arg Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Lys Asp Gln Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Ala Arg Phe 
    50                  55                  60                  


Val Tyr Glu Ile Ala Arg Glu His Gly Leu Arg Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Gln Lys Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Tyr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Trp Pro Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Arg Val Ala Gln Trp Tyr Pro Asn Leu Phe 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Arg Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Phe Glu Asp Val Leu Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Phe Pro Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Arg Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Arg Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val His Glu Ser Phe Ile Tyr 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Asn Gly Asn Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Glu Leu 
                405             


<210>  301
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  301

Met Trp Leu Glu His His Tyr Gly Arg Pro Phe Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Leu His Tyr Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Trp Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Phe Glu Ile Ala Lys Arg Lys Gly Leu Asp Leu Arg Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Arg Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Arg Asp Arg Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Arg Pro Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asp Ile Pro Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Glu Thr Ser Asp Gln Leu Arg Trp Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asp Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Pro Val Pro Ile Asp Phe Ile Arg 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Arg 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Asp 
                405             


<210>  302
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  302

Met Trp Leu Arg Phe His Tyr Asn Glu Pro Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Ala Ala Met 
            20                  25                  30          


His Val His Glu Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Trp Gln Gly Gly Tyr Ser Gly Met Thr Pro Thr Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Met Thr Ile Ala Arg Glu Lys Gly Leu Asp Glu Arg Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ala 
                85                  90                  95      


Pro Gln Ala Met Thr Tyr Ala Gln Ile Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Leu Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Trp Ser Glu Val Leu Pro Trp Glu Leu Ile Ala Glu Leu Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Val Ala Glu Glu Val Gly Gln Asp Met Pro Phe Leu Met 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Tyr Tyr Leu 
            180                 185                 190         


Phe Leu Tyr Phe Asn Asp Val Leu Asn Ile Arg Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Asp Val Val Phe Met 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Glu Glu Ile Leu Arg Glu Val Ser Arg Tyr 
225                 230                 235                 240 


Pro Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Leu Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Arg Arg Ser Gln Ile Ile Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Asp Arg Leu Tyr Trp Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Leu Tyr Pro Asp Val Trp Tyr Val Leu Leu 
            340                 345                 350         


Leu Leu Phe Trp Asn Phe Ser Glu Pro Val Asp Leu Arg Phe Ile Leu 
        355                 360                 365             


Arg Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Asp Gly Arg Met Ser 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Trp Tyr Ala Ile Asn Leu 
                405             


<210>  303
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  303

Met Trp Leu Pro Ala His Tyr Leu Arg Glu His Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Arg Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Asn Met His Glu Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Trp Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Tyr Lys Ile Ala Lys Glu Lys Gly Leu Arg Leu Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Glu 
                85                  90                  95      


Pro Ile Ala Met Gln Tyr Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Asp Leu Thr Arg Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Glu Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Asp Arg Leu 
            180                 185                 190         


Arg Glu Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Asp Gln Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Pro Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Gln Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Arg Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Arg Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Arg Thr Ser Glu Asp Leu Arg Tyr Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Gln Glu Val Leu Arg 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Pro Val Pro Pro Asn Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Arg Gly Leu Met Arg 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile His Asp 
                405             


<210>  304
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  304

Met Trp Leu Asp His His Tyr Leu Leu Asn Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ala 
            20                  25                  30          


Asn Met His Leu Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Met Asp Ile Ala Asp Arg Lys Gly Leu Asp Arg Asn Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ala 
                85                  90                  95      


Pro Gln Ala Met Asp Tyr Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Tyr Glu Val Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Val Ala Glu Glu Thr Ala Arg Glu Tyr Asn Phe Gln Ala 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Leu Leu 
            180                 185                 190         


Arg Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Asp Ile Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Glu Glu Ile Leu Arg Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asn Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser His Ile 
        275                 280                 285             


Glu Glu Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Ile Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Tyr Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Arg Thr Val Leu Glu 
            340                 345                 350         


Leu Leu Phe Arg Asn Phe Ser Glu Pro Val Pro Leu Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Arg Gly Leu Met Glu 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Asn Leu 
                405             


<210>  305
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  305

Met Trp Leu Asp Ala His Tyr Leu Arg Asp Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Arg Ala Ser Ile Ile Phe Ala Ile 
            20                  25                  30          


Arg Thr Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Met Ser Ile Ala Asp Glu Leu Gly Leu Asp Arg Asn Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ala 
                85                  90                  95      


Pro Arg Ala Met Glu Tyr Ala Arg Gln Leu Ile Ile Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Arg Leu Pro Leu Glu Val Ile Ala Arg Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Arg Tyr Ala Gln Glu Tyr Asn Val Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ala Ala Ile Glu Ala Leu 
            180                 185                 190         


Arg Arg Tyr Phe Asp Asp Val Pro Asn Ile Phe Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Glu Thr Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Arg Val Glu Glu Ile Leu Arg Glu Val Ser Arg Asp 
225                 230                 235                 240 


Gln Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Leu Asn Met Val Arg Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser His Ile 
        275                 280                 285             


Glu Glu Glu Ile Ile Pro Glu Arg Glu Arg Ala Asn Ile Ile Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Tyr Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Leu Thr Val Leu Glu 
            340                 345                 350         


Arg Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Met Arg Tyr Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Glu Arg Val Arg Arg Gly Glu Met Thr 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Leu Thr Glu Ile Met Leu Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Asn Asp 
                405             


<210>  306
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  306

Met Trp Thr Asp His Asn Tyr Leu Arg Glu Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Glu Met Gly Ser Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Trp Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Phe Glu Ile Ala Asp Arg Lys Gly Leu Glu Arg Asn Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Glu 
                85                  90                  95      


Pro Arg Ala Met Arg Tyr Ala Glu Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Pro Leu Glu Arg Ile Ala Glu Arg Thr Arg Arg 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Arg Tyr Arg Gln Gln Tyr Asn Val Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ala Ala Ile Glu Ala Leu 
            180                 185                 190         


Arg Arg Tyr Phe Ser Asp Val Met Asn Ile Tyr Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Gln Thr Val Phe Tyr 
    210                 215                 220                 


Tyr Asp Arg Ser Arg Val Glu Pro Ile Leu Arg Glu Val Ser Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Gln Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Glu Ile 
        275                 280                 285             


Glu Arg Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Ile Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Arg Thr Ser Glu Asp Leu Glu Tyr Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Pro Arg Leu Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Arg Gly Leu Met Thr 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile His Asp 
                405             


<210>  307
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  307

Met Trp Leu Met Leu Gln Tyr Leu Ile Asn Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Arg Ala Ser Ile Ile Ala Ala Leu 
            20                  25                  30          


Arg Tyr Asp Leu Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Ala Glu Phe 
    50                  55                  60                  


Val Tyr Arg Ile Ala Gln Glu Ile Gly Leu Glu Glu Asn Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Pro Leu Glu Val Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Asn Gln Glu 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Thr Leu 
            180                 185                 190         


Arg Asp Tyr Phe Ser Asp Val Pro Asn Ile Tyr Asn Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Asp Gln Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Glu Glu Ile Leu Arg Glu Val Ser Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Phe Ile 
        275                 280                 285             


Glu Gln Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Glu Asp Leu Glu Leu Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Glu Thr Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Ser Val Arg Arg Gly Leu Met Ser 
    370                 375                 380                 


Asn Asp Pro Arg Asp Leu Ile Leu Tyr Glu Ile Met Leu Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Phe Tyr Ala Ile Ile Leu 
                405             


<210>  308
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  308

Met Trp Leu Asn Gln Gln Tyr Leu Arg Arg Glu Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Tyr Asn Arg Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Phe Glu Ile Ala Asp Arg Lys Gly Leu Glu Arg Asn Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Glu 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Ser Glu Thr Leu Pro Tyr Pro Arg Ile Ala Glu Arg Thr Arg Ile 
    130                 135                 140                 


Leu Phe Glu Glu Ala Glu Arg Thr Ala Arg Glu Tyr Asn Asn Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Tyr Leu 
            180                 185                 190         


Arg Arg Tyr Phe Leu Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Asp Gln Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Asn Val Arg Pro Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Arg Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Glu Asp Leu Arg Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Glu Asn Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Pro Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Glu Leu 
                405             


<210>  309
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  309

Met Trp Leu Leu Leu Gln Tyr Leu Arg Asn Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Asp Arg Lys Gly Leu Glu Arg Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ala 
                85                  90                  95      


Pro Gln Ala Met Glu Tyr Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Leu Glu Val Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Asn Gln Glu 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Asp Thr Leu 
            180                 185                 190         


Arg Arg Tyr Phe Ser Asp Val Pro Asn Ile Tyr Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Phe Ile 
        275                 280                 285             


Glu Gln Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Pro Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  310
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  310

Met Trp Leu Met Leu Gln Tyr Leu Ile Asn Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Arg Ala Ser Ile Glu Phe Ala Leu 
            20                  25                  30          


Glu Thr Asn Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Arg Glu Phe 
    50                  55                  60                  


Val Met Arg Ile Ala Gln Glu Ile Gly Leu Glu Glu Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Ala Lys Ala Glu Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Pro Leu Glu Lys Ile Ala Glu Arg Thr Arg Arg 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Arg Thr Ala Arg Glu Tyr Asn Asn Gln Glu 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Asp Thr Leu 
            180                 185                 190         


Arg Arg Tyr Phe Ser Asp Val Pro Asn Ile Tyr Asn Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Glu Glu Ile Leu Arg Glu Val Ser Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Leu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Ile Val Leu Glu 
            340                 345                 350         


Leu Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Pro Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Arg Val Arg Asn Gly Asp Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Tyr Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Leu Tyr Ala Ile Gln Leu 
                405             


<210>  311
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  311

Met Trp Leu Ser Ala Gln Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Gln 
            20                  25                  30          


Glu Tyr Asn Thr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Asp Arg Lys Gly Leu Glu Arg Asn Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Ala Lys Ala Glu Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Leu Glu Lys Ile Ala Glu Arg Thr Arg Arg 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Arg Thr Ala Arg Glu Tyr Asn Asn Gln Glu 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Thr Leu 
            180                 185                 190         


Glu Arg Tyr Phe Ser Asp Val Pro Asn Ile Phe Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Asp Gln Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Leu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Asp Asp Ser Glu Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Ile Val Leu Glu 
            340                 345                 350         


Leu Leu Phe Arg Asn Phe Ser Glu Gly Val Asp Pro Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  312
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  312

Met Trp Thr Asp His Asp Tyr Leu Arg Arg Val Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Arg Ala Ser Ile Arg Phe Ala Arg 
            20                  25                  30          


Asp Asp Asp Thr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln His Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Tyr Arg Ile Ala Asp Glu Glu Gly Leu Arg Arg Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Arg Pro Glu 
                85                  90                  95      


Pro Glu Ala Met Asn Glu Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Arg Pro Ser Ser Leu Pro Tyr Pro Arg Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Glu Ala Glu Arg Tyr Ala Glu Gln Tyr Asn Leu Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Tyr Leu 
            180                 185                 190         


Arg Glu Tyr Phe Arg Asp Val Glu Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Glu Pro Ile Leu Arg Glu Val Ser Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Arg Ile 
        275                 280                 285             


Glu Glu Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Ile Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asn Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Glu Gly Leu Glu Tyr Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Pro Ile Asn Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Glu Ser Tyr Glu Asn Val Arg Arg Gly Leu Met Gln 
    370                 375                 380                 


Asn Asp Pro Arg Arg Leu Ile Leu Glu Glu Ile Met Arg Val Leu Arg 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile Arg Leu 
                405             


<210>  313
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  313

Met Trp Leu Met Leu Gln Tyr Leu Ile Asn Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Pro Tyr Val Ile Glu Ala Ser Ile Arg Phe Ala Gln 
            20                  25                  30          


Arg Thr Asn Leu Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Asp Arg Thr Gly Leu Glu Arg Asn Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ala 
                85                  90                  95      


Pro Gln Ala Met Glu Tyr Ala Lys Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Pro Tyr Glu Val Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Glu Tyr Asn Asn Gln Glu 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Arg Asp Tyr Phe Ser Asp Val Pro Asn Ile Tyr Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Ala Pro Ile Leu Glu Glu Val Lys Arg Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Phe Ile 
        275                 280                 285             


Glu Gln Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Glu Thr Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Ser Val Arg Glu Gly Leu Met Ser 
    370                 375                 380                 


Asn Asp Pro Arg Asp Leu Ile Leu Tyr Glu Ile Met Leu Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Leu Tyr Ala Ile Gln Leu 
                405             


<210>  314
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  314

Met Trp Leu Met Leu Gln Tyr Leu Ile Asn Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Arg Ala Ala Gln 
            20                  25                  30          


Glu Tyr Asn Leu Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Asp Arg Thr Gly Leu Glu Arg Asn Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ala 
                85                  90                  95      


Pro Thr Ala Met Glu Lys Ala Arg Gln Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Leu Glu Val Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Arg Thr Ala Arg Lys Tyr Asn Phe Gln Glu 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Thr Leu 
            180                 185                 190         


Arg Ala Tyr Phe Ser Asp Val Pro Asn Ile Tyr Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Asp Gln Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Glu Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Leu Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Pro Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Pro Asp Val Glu Thr Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Arg Gly Leu Met Ser 
    370                 375                 380                 


Asn Asp Pro Arg Asp Leu Ile Leu Ala Glu Ile Ile Leu Val Leu Arg 
385                 390                 395                 400 


Asp Tyr Phe Tyr Ala Ile His Leu 
                405             


<210>  315
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  315

Met Trp Leu Pro Ala His Tyr Leu Arg Glu His Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Asn Met Gly Glu Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Trp Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Tyr Glu Ile Ala Asp Arg Lys Gly Leu Glu Arg Asp Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Pro Tyr Asp Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Gln Met Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Arg Leu 
            180                 185                 190         


Arg Glu Tyr Phe Arg Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Gly Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Gln Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Arg Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Ile Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Arg Thr Ser Lys Gly Leu Glu Tyr Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Pro Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Arg 
    370                 375                 380                 


Pro Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile His Asp 
                405             


<210>  316
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  316

Met Trp Thr Asp His Ala Tyr Leu Arg Glu Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Arg Ala Ser Ile Arg Phe Ala Ile 
            20                  25                  30          


Glu Lys Gly Thr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Asp Glu Glu Gly Leu Arg Arg Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Glu 
                85                  90                  95      


Pro Thr Ala Met Gln Lys Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Val Leu Asp Asp Glu Arg Ile Ala Arg Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Arg Tyr Arg Gln Gln Tyr Arg Val Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Arg Ala Ile Asp Ala Leu 
            180                 185                 190         


Arg Arg Tyr Phe Ser Asp Val Pro Asn Ile Phe Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Gly Asp Gln Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Arg Val Glu Pro Ile Leu Arg Glu Val Ser Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Arg Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ala Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Pro Arg Tyr Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Glu Ser Tyr Glu Asp Val Arg Arg Gly Leu Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Asp Leu Ile Leu Ala Glu Ile Met Leu Val Leu Arg 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Asp 
                405             


<210>  317
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  317

Met Trp Leu Pro Ala His Tyr Leu Arg Arg Arg Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Asn Met Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Asp Arg Lys Gly Leu Arg Arg Asp Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Glu 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Asp Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Ala Leu Pro Arg Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Glu Ala Glu Glu Thr Ala Arg Gln Met Asn Phe Arg Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Tyr Leu 
            180                 185                 190         


Arg Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Gly Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Arg Pro Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Arg Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Ile Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Ser Thr Gly Lys Asp Leu Glu Tyr Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Arg Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Leu Ser Leu Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Glu Asp Val Arg Arg Gly Leu Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile His Asp 
                405             


<210>  318
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  318

Met Trp Leu Met Gln Ala Tyr Leu Ile Ala Ile Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Arg Ala Ser Ile Arg Ala Ala Gln 
            20                  25                  30          


Asn Tyr Asn Thr Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Tyr Arg Ile Ala Asp Glu Glu Gly Leu Glu Arg Asn Arg Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Glu 
                85                  90                  95      


Pro Gln Ala Met Gln Tyr Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Ser Glu Thr Leu Pro Tyr Pro Arg Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Val Ala Glu Arg Thr Ala Arg Glu Tyr Asp Asn Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Tyr Leu 
            180                 185                 190         


Arg Arg Tyr Phe Glu Asp Val Met Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Gln Thr Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Glu Pro Ile Leu Arg Glu Val Ser Ser Thr 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Leu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Arg Ile 
        275                 280                 285             


Glu Gln Glu Ile Ile Pro Glu Arg Leu Arg Ser Asn Ile Leu Glu Val 
    290                 295                 300                 


Ile Leu Arg Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asn Tyr Tyr 
305                 310                 315                 320 


Arg Asp Ser Glu Asp Leu Arg Tyr Asp Ile Leu Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Glu Gln Val Leu Arg 
            340                 345                 350         


Glu Leu Phe Arg His Phe Ser Glu Gly Val Asp Pro Arg Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Arg Val Arg Asn Gly Glu Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Asp Leu Ile Glu Ala Glu Ile Gln Glu Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Phe Tyr Ala Ile Ile Leu 
                405             


<210>  319
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  319

Met Trp Leu Ser His Asp Tyr Leu Arg Glu His Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Arg Phe Ala Ile 
            20                  25                  30          


Asn Met His Asp Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Trp Thr Pro Ser Asp Phe Arg Asp Phe 
    50                  55                  60                  


Val Tyr Glu Ile Ala Asp Arg Thr Gly Leu Glu Arg Asn Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Glu 
                85                  90                  95      


Pro Thr Ala Met Gln Lys Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Asp Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Glu Thr Leu Ala Leu Pro Arg Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Glu Ala Glu Glu Ala Ala Arg Lys Met Asn Phe Arg Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Glu Tyr Leu 
            180                 185                 190         


Arg Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Arg Phe Ser Tyr Asp Gln Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Ser Gln Val Arg Pro Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Gln Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Arg Thr Ser Glu Gly Leu Arg Tyr Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Arg Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Arg 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Leu Ala Glu Ile Met Glu Val Leu Arg 
385                 390                 395                 400 


Asp Tyr Ala Tyr Ala Ile His Asp 
                405             


<210>  320
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  320

Met Trp Leu Pro Ala His Tyr Leu Arg Glu His Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Glu Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Ile 
            20                  25                  30          


Glu Met His Asp Pro Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Arg Phe 
    50                  55                  60                  


Val Met Glu Ile Ala Asp Arg Leu Gly Leu Glu Arg Asn Leu Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Leu Pro Ser 
                85                  90                  95      


Pro Gln Ala Met Gln Tyr Ala Arg Glu Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Thr Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Leu Pro Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Arg Glu Ala Glu Glu Thr Ala Arg Gln Met Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Ile Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Asp Glu Leu 
            180                 185                 190         


Arg Arg Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Gln Val Arg Pro Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Gln Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Asp Tyr Tyr 
305                 310                 315                 320 


Ser Thr Ser Lys Asp Leu Glu Tyr Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Asn Tyr Pro Asp Val Arg Glu Val Leu Arg 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Pro Val Pro Leu Ser Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Leu Ser Tyr Phe Asp Val Arg Glu Gly Leu Met Glu 
    370                 375                 380                 


Pro His Pro Glu Arg Leu Ile Arg Ala Glu Ile Met Glu Val Leu Arg 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile His Asp 
                405             


<210>  321
<211>  494
<212>  PRT
<213>  Pseudothermotoga thermarum

<400>  321

Met Lys Leu Leu Glu Glu Phe Leu Lys Ala Phe Pro Gly Arg Phe Lys 
1               5                   10                  15      


Val Tyr Gly Ser Ser Leu Arg Ile Ile Thr Asp Ser Tyr Phe Phe Leu 
            20                  25                  30          


Gly Asn Asp Gly Lys Glu Lys Leu Leu Phe Val Val Gly Lys Lys Gly 
        35                  40                  45              


Ile Cys Gln Leu Phe Asp Gly Gln Lys Ile Gly Gln Ile Gly Ser Asn 
    50                  55                  60                  


Asp Val Leu Met Cys Lys Lys Thr His Glu Asn Leu Leu Ala Leu Arg 
65                  70                  75                  80  


Lys Ile Ile Asn Leu Asn Pro Thr Thr Ile Asn Lys Lys Ala Ser Phe 
                85                  90                  95      


Gly Phe Gly Asp Arg Ile Gly Leu Ala Thr Pro Ala His Ala Lys Val 
            100                 105                 110         


Ala Lys Asp Phe Glu Val Phe Pro Ile Phe Ala Gln Gln Ser Val Arg 
        115                 120                 125             


Glu Leu Ser Arg Thr Gly Arg Thr Tyr Lys Asp Val Leu Asp Asp Ala 
    130                 135                 140                 


Val Trp Gly Val Phe Glu Ser Gly Tyr Asn Phe Glu Phe Gly Ala Asp 
145                 150                 155                 160 


Ala Asp His Val Lys Glu Ile Glu Asp Leu Glu Lys Ala Ser Asn Glu 
                165                 170                 175     


Gly Phe Thr Met Tyr Thr Val Asp Pro Ser Asp His Ile Lys Asp Val 
            180                 185                 190         


Ser Lys Leu Ser Gln Lys Glu Phe Gln Ser Leu Tyr Gln Asp Asn Lys 
        195                 200                 205             


Ile Arg Arg Glu Leu Glu Met Arg Tyr Val Gly Lys Leu Tyr Lys Phe 
    210                 215                 220                 


Lys Asp Phe Glu Phe Arg Met Thr Asp Glu Glu Phe Ala Glu Ile Phe 
225                 230                 235                 240 


Val Thr Tyr Ile Asp Ala Ile Glu His Val Cys Lys Cys Tyr Asp Val 
                245                 250                 255     


Leu Lys Ala Lys Gly Lys Pro Phe Asp Phe Glu Val Ser Ile Asp Glu 
            260                 265                 270         


Thr Ala Val Pro Thr Thr Pro Leu Ala His Ile Phe Ile Val Lys Glu 
        275                 280                 285             


Leu Arg Arg Arg Gly Ile Asp Phe Lys Thr Leu Ala Leu Arg Phe Ser 
    290                 295                 300                 


Gly Glu Trp Gln Lys Gly Ile Asp Tyr Ile Gly Asp Met Glu Met Phe 
305                 310                 315                 320 


Arg Lys Glu Ile Ile Thr His Ser Lys Ile Ser Lys Glu Leu Gly Gly 
                325                 330                 335     


Tyr Lys Leu Ser Leu His Ser Gly Ser Asp Lys Phe Ser Val Tyr Pro 
            340                 345                 350         


Ile Phe Ser Glu Ala Thr Glu Gly Glu Phe His Val Lys Thr Ala Gly 
        355                 360                 365             


Thr Asn Tyr Leu Glu Ala Ile Arg Val Val Ala Val Lys Asp Pro Glu 
    370                 375                 380                 


Leu Tyr Arg Glu Ile His Lys Phe Ala Leu Thr Lys Phe Glu Gln Asp 
385                 390                 395                 400 


Arg Lys Ser Tyr His Val Thr Thr Asp Leu Ser Lys Ile Pro Asp Val 
                405                 410                 415     


Asp Lys Met Lys Asn Glu Glu Leu Val Lys Leu Leu Asp Met Pro Asp 
            420                 425                 430         


Ser Arg Gln Leu Ile His Ile Thr Tyr Gly Ser Val Leu Thr Ala Lys 
        435                 440                 445             


Asp Glu Asn Gly Arg Trp Leu Phe Lys Glu Arg Ile Leu Lys Val Leu 
    450                 455                 460                 


Gln Glu Asn Glu Asp Leu His Tyr Asp Phe Val Glu Lys His Met Arg 
465                 470                 475                 480 


Lys His Leu Ser Leu Leu Gly Leu Glu Arg Arg Ile Glu Lys 
                485                 490                 


<210>  322
<211>  487
<212>  PRT
<213>  Pseudothermotoga hypogea

<400>  322

Met Phe Ala Glu Phe Gln His Leu Thr Arg Gly Lys Phe Val Pro Tyr 
1               5                   10                  15      


Ala Thr Ser Leu Arg Lys Ser Thr Asp Ala Thr Phe Phe Leu Val Arg 
            20                  25                  30          


Asp Glu Leu Asp Lys Tyr Leu Ile Val Ile Gly Lys Lys Gly Ile Cys 
        35                  40                  45              


Glu Leu Phe Glu Gly Gln Lys Ile Gly Glu Ile Asp Arg Gln Asp Val 
    50                  55                  60                  


Val Leu Cys Ala Lys Asn Asp Arg Asn Cys Gln Ser Leu Met Ser Leu 
65                  70                  75                  80  


Phe Pro Ser Leu Lys Pro Gln Ile Cys Asn Ala Lys Leu Ser Phe Gly 
                85                  90                  95      


Phe Gly Asp Arg Leu Gly Val Ala Thr Ala Ala His Ala Gln Cys Val 
            100                 105                 110         


Gln Lys Glu Lys Leu Phe Pro Ile Phe Ala Gln Gln Ser Val Arg Glu 
        115                 120                 125             


Ile Ser Arg Thr Glu Arg Asn Trp Leu Asp Val Leu His Ser Ala Val 
    130                 135                 140                 


Trp Gly Val Phe Glu Ser Gly Tyr Asp Gly Pro Phe Gly Ala Asp Ala 
145                 150                 155                 160 


Asp His Val Lys Lys Ile Glu Asp Leu Glu Ser Ala Ala Arg Ala Gly 
                165                 170                 175     


Tyr Thr Met Phe Thr Ile Asp Pro Ser Asp His Val Lys Asp Pro Ala 
            180                 185                 190         


Lys Phe Asp Lys Arg Glu Leu Val Arg Phe Tyr Glu Glu His Pro Met 
        195                 200                 205             


Arg Arg Thr Leu Glu Met Lys Tyr Ile Gly Lys Ser Phe Thr Val Leu 
    210                 215                 220                 


Gly Glu Lys Leu Thr Phe Asp Glu Glu Asn Phe Ala Glu Val Phe Val 
225                 230                 235                 240 


Thr Tyr Ile Asp Ala Ile Glu His Val Glu Lys Cys Tyr Arg Ala Leu 
                245                 250                 255     


Arg Ala Val Cys Lys Thr Ser Phe Asp Leu Glu Val Ser Ile Asp Glu 
            260                 265                 270         


Thr Ser Val Pro Thr Thr Ser Leu Ala His Ile Phe Phe Val Gln Glu 
        275                 280                 285             


Leu Val Arg Arg Gly Val Glu Phe Arg Thr Leu Ala Leu Arg Phe Pro 
    290                 295                 300                 


Gly Glu Trp Gln Lys Gly Ile Asp Tyr Val Gly Asp Ile Asp Leu Phe 
305                 310                 315                 320 


Ser Glu Asn Leu Asp Lys His Val Ala Ile Val Lys Met Phe Thr Gly 
                325                 330                 335     


Tyr Arg Leu Ser Leu His Ser Gly Ser Asp Lys Phe Ser Val Tyr Pro 
            340                 345                 350         


Ile Leu Ala Glu Lys Thr Asp Arg Thr Ile His Val Lys Thr Ala Gly 
        355                 360                 365             


Thr Ser Tyr Leu Glu Ala Ile Arg Val Val Ala Lys Phe Ala Pro Asp 
    370                 375                 380                 


Leu Tyr Arg Gln Ile His Lys Tyr Ala Leu Ser Arg Phe Asp Gln Asp 
385                 390                 395                 400 


Lys Ala Ser Tyr His Val Thr Thr Glu Leu Ser Lys Ile Pro Asp Val 
                405                 410                 415     


Asp Lys Leu Glu Asp Ser Glu Leu Pro Ser Leu Leu Asp Gln Pro Asp 
            420                 425                 430         


Ser Arg Gln Leu Ile His Ile Thr Tyr Gly Ser Val Leu Thr Ala Lys 
        435                 440                 445             


Lys Glu Gly Arg Ser Leu Phe Lys Asp Arg Ile Met Arg Val Leu Phe 
    450                 455                 460                 


Glu His Glu Ala Glu His Tyr Asp Phe Leu Lys Lys His Leu Gly Lys 
465                 470                 475                 480 


His Ile Gln Leu Leu Gly Val 
                485         


<210>  323
<211>  489
<212>  PRT
<213>  Pseudothermotoga lettingae

<400>  323

Met Ala Glu Asn Ile Val Glu Lys Phe Glu Lys Leu Phe Lys Gly Lys 
1               5                   10                  15      


Tyr Lys Ile Tyr Tyr Ser Ser Ile Arg Lys Leu Glu Lys Ser Phe Phe 
            20                  25                  30          


Phe Met Ile Arg Asp Gln Lys Gln Lys Tyr Leu Ile Ser Ile Ala Lys 
        35                  40                  45              


Lys Arg Ile Cys Glu Lys Phe Glu Gly Lys Lys Ile Gly Arg Ile Asn 
    50                  55                  60                  


Asp Leu Asp Ile Leu Met Cys Pro Thr Asn Asp Tyr Asn Cys Lys Val 
65                  70                  75                  80  


Ile Arg Thr Leu Phe Asn Ile Asn Pro Ser Val Cys Lys Lys Asn Thr 
                85                  90                  95      


Ser Phe Gly Phe Gly Asp Arg Leu Gly Leu Ala Thr Pro Ala His Thr 
            100                 105                 110         


Thr Leu Ile Asn Lys Tyr Asp Val Phe Pro Val Leu Ala Gln Gln Ser 
        115                 120                 125             


Val Arg Glu Leu Ser Arg Thr His Arg Asn Phe Lys Asp Val Leu Asp 
    130                 135                 140                 


Ser Ala Ile Trp Gly Ile Phe Glu Ser Gly Tyr Glu Gly Glu Phe Gly 
145                 150                 155                 160 


Ala Asp Ala Asp His Val Lys Asp Ile Asn Asp Leu Met Gln Ala Ala 
                165                 170                 175     


Tyr Glu Gly Tyr Ser Met Tyr Thr Val Asp Pro Ser Asp His Val Lys 
            180                 185                 190         


Asn Ile Asp Lys Ile Asn Gln Gly Glu Leu Val Glu Phe Tyr Lys Ser 
        195                 200                 205             


His Pro Leu Arg Lys Glu Ile Glu Met Ile Tyr Ser Gly Lys Val Phe 
    210                 215                 220                 


Ser Phe Glu Lys Ser Lys Phe Thr Met Glu Asp Lys Glu Leu Phe Arg 
225                 230                 235                 240 


Ile Phe Val Thr Tyr Val Asp Ala Ile Glu His Val Val Lys Cys Tyr 
                245                 250                 255     


Glu Ala Ile Lys Asn Thr Lys Lys Asn Phe Asp Phe Glu Val Ser Ile 
            260                 265                 270         


Asp Glu Thr Ser Ile Pro Thr Ser Pro Leu Ala His Ile Phe Ile Val 
        275                 280                 285             


His Glu Leu Arg Arg Arg Gly Val Asp Phe Gln Thr Leu Ala Leu Arg 
    290                 295                 300                 


Phe Val Gly Gln Trp Gln Lys Ala Ile Asp Tyr Ile Gly Asp Leu Ser 
305                 310                 315                 320 


Val Leu Glu Ser Glu Leu Ser Met His Cys Glu Ile Val Lys Ser Leu 
                325                 330                 335     


Ser Gly Tyr Arg Leu Ser Leu His Ser Gly Ser Asp Lys Phe Ser Val 
            340                 345                 350         


Tyr Arg Ile Phe Thr His Tyr Cys Asp Gly Lys Leu His Val Lys Thr 
        355                 360                 365             


Ala Gly Thr Ser Tyr Leu Glu Ala Ile Arg Thr Val Ala Glu Ala Ser 
    370                 375                 380                 


Pro Ser Leu Tyr Arg Asn Ile His Lys Tyr Ala Leu Thr Cys Phe Glu 
385                 390                 395                 400 


Lys Asp Asn Thr Ser Tyr His Val Thr Ala Asp Ile Asn Lys Ile Pro 
                405                 410                 415     


Asp Val Asp Asn Val Glu Asp Ser Lys Val Val Asn Leu Leu Asp Ile 
            420                 425                 430         


Pro Glu Val Arg Gln Leu Ile His Ile Thr Tyr Gly Ser Val Leu Thr 
        435                 440                 445             


Glu Lys Ile Asn Gly Lys Tyr Leu Phe Arg Asp Glu Ile Tyr Arg Ile 
    450                 455                 460                 


Leu His Glu Asn Glu Phe Leu His Tyr Lys Arg Ile Arg Asp His Leu 
465                 470                 475                 480 


Gly Lys His Leu Glu Leu Leu Lys Asn 
                485                 


<210>  324
<211>  519
<212>  PRT
<213>  Rhodothermus marinus

<400>  324

Met Val Thr Val Leu Gln Thr Leu Leu Gln Arg Pro Arg Pro Leu Ala 
1               5                   10                  15      


Glu Ile Asp Arg Thr Ser Leu Ala Arg Phe Leu Thr Asp Val Ile Arg 
            20                  25                  30          


Gln Gln Val Tyr Pro Thr Ser Leu Glu Pro Thr Ser Glu Gly Val Phe 
        35                  40                  45              


Phe Leu Ala Arg Asp Gly Arg Glu Lys Arg Leu Gly Ile Leu Ser Glu 
    50                  55                  60                  


Ala Gly Leu His Asp Phe Glu Gly Val Arg His Gln Leu Ser Leu Asp 
65                  70                  75                  80  


Gly Arg Thr Leu Ile Phe Gln Ser Cys Pro Leu Thr Ala Ala Asn Ala 
                85                  90                  95      


Arg Ala Leu Arg Arg His Ile Pro Trp Thr Ala Pro Arg Pro Leu Gly 
            100                 105                 110         


Leu Arg Ala Ser Val Gly Cys Gly Asp Arg Leu Gly Leu Ala Thr Pro 
        115                 120                 125             


Gly His Val Arg Ala Val Arg Lys His Lys Leu Ala Pro Val Phe Ala 
    130                 135                 140                 


Gln Gln Ser Ile Arg Glu Met Thr Arg Thr Gly Arg Thr Pro Gln Gln 
145                 150                 155                 160 


Val Leu Asp Glu Ala Met Trp Gly Val Phe Gln Glu Gly Trp Arg Gln 
                165                 170                 175     


Gly Tyr Gly Ala Asp Ala Asp His Leu Lys Thr Glu Glu Asp Ala Asp 
            180                 185                 190         


Arg Cys Ile Glu Ala Gly Phe Thr Phe Phe Thr Ile Asp Pro Ser Ala 
        195                 200                 205             


Tyr Val Asp Asn Glu Val Asp Thr Ala Asp Ala Ala Thr Leu Glu Ala 
    210                 215                 220                 


Lys Val Ala Ala Leu Pro Trp Glu Ala Leu Glu Thr Thr Leu Ala Asp 
225                 230                 235                 240 


Leu Arg Arg Ala Tyr Leu Gly Gln His Phe Gln Val Gly Pro Tyr Glu 
                245                 250                 255     


Leu Ser Phe Glu Glu Arg Thr Leu Met Gln Ala Leu Ala Lys Tyr Gly 
            260                 265                 270         


Gly Ala Ile Ala His Thr Ala Arg Met Tyr Arg His Ile Ala Gly Arg 
        275                 280                 285             


Met Gly Asn Arg Pro Phe Glu Leu Glu Met Ser Val Asp Glu Thr Glu 
    290                 295                 300                 


Val Pro Thr Ser Pro Ala Glu His Phe Phe Val Ala Arg Glu Leu Gln 
305                 310                 315                 320 


Arg Leu Gly Val Arg Trp Ile Ser Leu Ala Pro Arg Phe Val Gly Arg 
                325                 330                 335     


Leu Glu Lys Gly Val Asp Tyr Ile Gly Asp Leu Glu Glu Phe Glu Ala 
            340                 345                 350         


His Leu Lys Leu His Val Ala Ile Ala Arg Thr Leu Gly Pro Tyr Lys 
        355                 360                 365             


Leu Ser Leu His Ser Gly Ser Asp Lys Phe Ala Leu Tyr Pro Leu Phe 
    370                 375                 380                 


Ala Arg His Ala Gly Glu Leu Phe His Leu Lys Thr Ala Gly Thr Ser 
385                 390                 395                 400 


Tyr Leu Glu Ala Leu Arg Ala Val Ala Glu Leu Asp Pro Pro Leu Phe 
                405                 410                 415     


Arg Glu Ile Leu Asp Phe Ala Arg Asp Arg Tyr Glu Thr Asp Arg Ala 
            420                 425                 430         


Thr Tyr His Val Ser Ala Leu Leu Glu Arg Val Pro Lys Ala Ser Asp 
        435                 440                 445             


Val Pro Asp Asp Ala Leu Pro Ala Leu Leu Glu Gln Phe Asp Thr Arg 
    450                 455                 460                 


Gln Val Leu His Val Thr Phe Gly Ser Val Leu Thr Ala Thr Asp Ala 
465                 470                 475                 480 


Asp Gly Arg Pro Arg Phe Arg Asp Arg Leu Leu Ala Val Leu Gln Glu 
                485                 490                 495     


Asn Glu Glu Thr Tyr Tyr Arg Leu Leu Glu Ala His Phe Asp Arg His 
            500                 505                 510         


Leu Ala Pro Phe Asp Ala Glu 
        515                 


<210>  325
<211>  496
<212>  PRT
<213>  Geosporobacter subterraneus

<400>  325

Met Asp Ile Tyr Glu Lys Ile Ala Ala Ala Leu Lys Asp Asn Arg His 
1               5                   10                  15      


Asn Ile Gln Leu Asp Gly Val Lys Ile Tyr Pro Gln Ser Tyr Val Glu 
            20                  25                  30          


Val Asp Met Val Lys Met Ile Met Val Lys Ala Ala Glu Lys Lys Val 
        35                  40                  45              


Ile Leu Ala Gln Gly Ser Gly Pro Leu Phe Gln Glu Leu Glu Gly Glu 
    50                  55                  60                  


Ala Tyr Asp Asp Tyr Lys Val Cys Asn Cys Ser His Leu Asn Arg Val 
65                  70                  75                  80  


Val Leu Asn Lys Tyr Leu Pro Tyr Thr Lys Pro Ser Ala Phe Gly Lys 
                85                  90                  95      


Glu Ile Ala Thr Ile Gly Leu Gly Asp Arg Leu Gly Ile Ala Ser Pro 
            100                 105                 110         


Gly His Ile Gln Ala Val Lys Gly Arg Glu Ile Arg Pro Ile Leu Ala 
        115                 120                 125             


Gln Gln Ser Ile Arg Glu Leu Asn Leu Thr Asn Arg Thr Tyr Arg Asn 
    130                 135                 140                 


Val Leu Asp Ala Ala Cys Phe Ala Val Phe Gln Glu Gly Tyr Lys Asp 
145                 150                 155                 160 


Gly Phe Gly Ala Asp Gly Asp His Leu Lys Thr Glu Glu Asp Ile Gln 
                165                 170                 175     


Ser Ala Leu Asp Leu Gly Phe Thr Met Ile Thr Leu Asp Cys Ser Glu 
            180                 185                 190         


Met Ile Asp Asn Thr Ile Asp Lys Leu Thr Asp Thr Glu Val Glu Glu 
        195                 200                 205             


Lys Tyr Tyr Gln Leu Pro Gln Ser Val Arg Glu Arg Tyr Glu Thr Arg 
    210                 215                 220                 


Tyr Leu Asp Lys Cys Phe Glu Leu Arg Asn Ser Lys Ile Cys Phe Ser 
225                 230                 235                 240 


Lys Glu Asn Leu Met Lys Asn Val Leu Ile Tyr Gly Ala Ala Ala Asp 
                245                 250                 255     


Phe Ile Val Ala Ile Tyr Glu Lys Gln Ile Lys His Arg Asp Gln Lys 
            260                 265                 270         


Ile Asp Phe Glu Val Ser Ile Asp Glu Thr Val Thr Pro Thr Thr Pro 
        275                 280                 285             


Glu Ala His Tyr Phe Val Ala Arg Glu Ile Tyr Asp Arg Gln Val Asp 
    290                 295                 300                 


Ile Asn Ser Met Ala Pro Arg Phe Cys Gly Glu Phe Gln Lys Gly Ile 
305                 310                 315                 320 


Asp Tyr Ile Gly Asp Ile His Gln Phe Glu Lys Glu Phe Gln Val His 
                325                 330                 335     


Ala Glu Ile Ala Asp His Phe Gly Tyr Lys Ile Ser Ile His Ser Gly 
            340                 345                 350         


Ser Asp Lys Phe Ser Val Phe Gln Thr Ile Gly Arg Tyr Thr Glu Gly 
        355                 360                 365             


Arg Phe His Val Lys Thr Ala Gly Thr Asn Trp Leu Glu Ala Val Arg 
    370                 375                 380                 


Val Val Ala Glu Lys Asn Pro Asn Leu Tyr Arg Lys Met His Gln Tyr 
385                 390                 395                 400 


Ala Leu Glu His Phe Asp Glu Ala Arg Ala Tyr Tyr His Val Thr Thr 
                405                 410                 415     


Asp Ile Glu Gly Ile Val Pro Leu Glu Lys Val Asn Asp His Glu Leu 
            420                 425                 430         


Ser Gln Tyr Met Asn Glu Asn Asn Ala Arg Gln Leu Leu His Ile Thr 
        435                 440                 445             


Tyr Gly Ile Leu Leu Gln Ala Lys Asp Ala Ser Gly Gln Tyr Leu Phe 
    450                 455                 460                 


Arg Glu Asp Phe Phe Tyr Thr Leu Glu Gln His Glu Ala Glu Tyr Asp 
465                 470                 475                 480 


Glu Ala Leu Arg Lys His Ile Gly Arg His Leu Glu Gln Leu Gly Lys 
                485                 490                 495     


<210>  326
<211>  517
<212>  PRT
<213>  Melioribacter roseus

<400>  326

Met Glu Met Gln Lys Leu Tyr Glu Glu Val Glu Asn Lys Asn Ile Val 
1               5                   10                  15      


Lys Asn Asp Leu Val Asp Leu Thr Ile Gly Glu Ser Leu Lys Ile Lys 
            20                  25                  30          


Ala Tyr Pro Leu Ser Val Leu Lys Lys Asp Asp Ala Phe Phe Phe Ile 
        35                  40                  45              


Gly Lys Glu Asn Tyr Asp Lys Phe Leu Phe Val Ile Ser Ala Gly Lys 
    50                  55                  60                  


Glu Asn Gly Leu Leu Asn Glu Phe Glu Gly Glu Leu Ile Asp Ala Gly 
65                  70                  75                  80  


Lys Asp Val Thr Val Lys Lys Cys Asn Leu Ser Thr Lys Asn Arg Lys 
                85                  90                  95      


Ala Val Gln Lys Ile Phe Pro His Thr Ala Pro Ile Val Leu Gly Leu 
            100                 105                 110         


Cys Asn Ser Phe Gly Cys Gly Asp Arg Leu Gly Val Ala Asn Ala Gly 
        115                 120                 125             


His Ile Arg Ala Ile Lys Gln Ser Asn Phe Arg Pro Ile Leu Ala Gln 
    130                 135                 140                 


Gln Ser Ile Arg Glu Leu Thr Arg Thr Asn Arg Thr Pro Asp Asp Val 
145                 150                 155                 160 


Met Asp Ala Ala Val Trp Ala Val Leu Gln Glu Gly Tyr Lys Asp Gly 
                165                 170                 175     


Phe Gly Ser Asp Ala Asp His Leu Lys Thr Phe Glu Asp Ile Asp Leu 
            180                 185                 190         


Met Leu Asn Ala Gly Phe Thr Met Phe Thr Phe Asp Pro Ser Glu His 
        195                 200                 205             


Val Asp Asn Glu Ala Asp Asn Tyr Ser Glu Asp Gln Leu Lys Gln Lys 
    210                 215                 220                 


Leu Gly Glu Ile Asp Trp Ser Gly Leu Gln Asp Thr Ser Ala Asp Ala 
225                 230                 235                 240 


Ala Lys Arg Tyr Val Asp Met Thr Phe Asn Ile Ser Glu Arg Leu Ser 
                245                 250                 255     


Leu Thr Ile Gln Glu Ser Asp Phe Leu Arg Ala Tyr Ala Lys Tyr Gly 
            260                 265                 270         


Asn Ala Ile Ala His Ile Lys Lys Met Tyr Asp Tyr Leu Ala Ser Lys 
        275                 280                 285             


Ala Asp Lys Asp Thr Phe Glu Ile Glu Val Ser Val Asp Glu Thr Glu 
    290                 295                 300                 


Ser Val Thr Ser Pro Phe Glu His Phe Phe Phe Ala Asn Glu Leu Asn 
305                 310                 315                 320 


Arg Leu Gly Val Lys Tyr Val Ser Leu Ala Pro Arg Phe Ile Gly Asp 
                325                 330                 335     


Phe Glu Lys Gly Ile Asp Tyr Lys Gly Asp Leu Asn Val Phe Lys Thr 
            340                 345                 350         


Glu Tyr Glu Lys His Leu Asp Ile Thr Lys Tyr Phe Gly Ser Tyr Lys 
        355                 360                 365             


Ile Ser Leu His Ser Gly Ser Asp Lys Phe Ser Ala Tyr Arg Val Ile 
    370                 375                 380                 


Gly Ser Leu Lys Gly Ala Tyr Thr His Val Lys Thr Ala Gly Thr Ser 
385                 390                 395                 400 


Tyr Leu Glu Ala Leu Arg Val Val Ala Ala Lys Glu Pro Ala Leu Phe 
                405                 410                 415     


Arg Asp Ile Leu Asp Phe Cys Arg Asp Leu Tyr Glu Thr Glu Lys Arg 
            420                 425                 430         


Ser Tyr His Val Ser Ala Asp Ile Asn Lys Val Lys Pro Ala Asn Gln 
        435                 440                 445             


Tyr Ser Asp Thr Glu Leu Ile Glu Leu Phe Asn Gln Asn Asp Thr Arg 
    450                 455                 460                 


Gln Val Leu His Val Thr Phe Gly Lys Val Leu Thr Glu Lys Asp Ser 
465                 470                 475                 480 


Ser Gly His Phe Leu Phe Lys Asp Lys Ile Met Lys Cys Leu Val Glu 
                485                 490                 495     


Asn Glu Glu Ser His Tyr Glu Phe Leu Glu Lys His Phe Leu Lys His 
            500                 505                 510         


Leu Glu Cys Phe Lys 
        515         


<210>  327
<211>  497
<212>  PRT
<213>  Lysinibacillus sphaericus

<400>  327

Met Lys Gln Phe Leu Pro Ala Ile Glu Leu Leu Ala Lys Gly Glu Leu 
1               5                   10                  15      


Pro Ser Asn Ser Asn Gln Ile Lys Val Tyr Glu Lys Ser Tyr Thr Val 
            20                  25                  30          


Glu Gly Asn Val His Leu Leu Met Val Lys Asn Ser Gly Glu Lys Phe 
        35                  40                  45              


Ile Leu Ala Thr Gly Glu Gly Ala Ile Phe Asp Glu Leu Thr Gly Thr 
    50                  55                  60                  


Asp Val Asp Gly Lys Gly Lys Ala Cys Pro Leu Thr Tyr Glu Asn Arg 
65                  70                  75                  80  


Leu Val Leu Asn Lys Tyr Phe Asp Tyr Thr Val Pro Gln Ala Phe Gly 
                85                  90                  95      


Thr Glu Ile Ala Thr Ile Gly Leu Gly Asp Arg Leu Gly Leu Ala Ser 
            100                 105                 110         


Pro Gly His Ile Glu Thr Val Arg Glu Lys Asn Ile Lys Pro Val Leu 
        115                 120                 125             


Ala Gln Gln Ser Ile Arg Glu Leu Thr Leu Thr Asn Arg Ser Met Asn 
    130                 135                 140                 


Asp Met Leu Asp Ala Ala Ala Phe Ala Val Phe Gln Glu Gly Tyr Lys 
145                 150                 155                 160 


Gly Gly Tyr Gly Ala Asp Gly Asp His Ile Lys Glu Glu Ser Asp Ile 
                165                 170                 175     


Gln Tyr Ala Leu Ser Leu Gly Ala Ser Met Ile Thr Leu Asp Cys Ser 
            180                 185                 190         


Asp His Ile Asp Asn Thr Ile Glu Lys Ala Ser Pro Glu Val Leu Asp 
        195                 200                 205             


Glu Lys Phe Asn Ala Leu Ser Glu Val Val Lys Gln Arg Tyr Met Glu 
    210                 215                 220                 


Gln Tyr Leu Gly Lys Thr Phe Glu Val Asn Gly Leu Thr Leu Thr Leu 
225                 230                 235                 240 


Asp Glu Thr Glu Leu Lys Lys Asn Val Leu Leu Tyr Asp Lys Ala Ile 
                245                 250                 255     


Asp Tyr Thr Thr His Val Tyr Asn Glu Tyr Ile Ser Lys Glu Asn Arg 
            260                 265                 270         


Ala Ile Asp Phe Glu Ile Ser Ile Asp Glu Thr Glu Thr Val Thr Ser 
        275                 280                 285             


Pro Ile Ser His Phe Phe Val Ala Asn Glu Leu Ile Asn Arg Gly Val 
    290                 295                 300                 


Lys Val Val Ser Leu Ala Pro Arg Phe Cys Gly Glu Phe Gln Lys Gly 
305                 310                 315                 320 


Ile Asp Tyr Ile Gly Asp Val Glu Gln Phe Glu Val Glu Leu Arg Glu 
                325                 330                 335     


His Ala Leu Ile Ala Glu His Phe Gly Tyr Lys Leu Ser Ile His Ser 
            340                 345                 350         


Gly Ser Asp Lys Phe Met Val Phe Pro Ile Ile Ala Glu Tyr Thr Lys 
        355                 360                 365             


Gly Val Phe His Val Lys Thr Ala Gly Thr Asn Trp Leu Glu Ala Ile 
    370                 375                 380                 


Arg Val Ile Ala Ala Thr Asn Pro Asp Leu Tyr Arg Arg Met His Val 
385                 390                 395                 400 


Phe Ala Leu Glu Asn Phe Glu Glu Ala Leu Lys Tyr Tyr His Val Thr 
                405                 410                 415     


Pro Asp Leu Asn Ser Phe Glu Lys Leu Glu Asn Val Glu Asp Ala Lys 
            420                 425                 430         


Leu Pro Glu Tyr Met Asn Asn Asp Ala Ala Arg Gln Leu Phe His Val 
        435                 440                 445             


Thr Tyr Gly Leu Leu Leu Thr Ala Lys Gly Glu Asn Asp Thr Phe Leu 
    450                 455                 460                 


Phe Arg Asp Glu Phe Phe Lys Thr Leu Asp Lys Tyr Glu Glu Glu Tyr 
465                 470                 475                 480 


Arg Asp Ala Leu Val Ser His Ile Gly Lys His Ile Glu Leu Leu Gly 
                485                 490                 495     


Leu 
    


<210>  328
<211>  510
<212>  PRT
<213>  Clostridium stercorarium

<400>  328

Met Gly Asn Trp Lys Asp Phe Val Lys Asp Phe Cys Thr Lys Glu Lys 
1               5                   10                  15      


Asn Ile Glu Val Leu Arg Ala Glu Ala Glu Lys Ala Phe Gly Asn Tyr 
            20                  25                  30          


Gly Val Tyr Pro Arg Ser Ile Asn Glu Val Gly Asn Ala Ile Val Met 
        35                  40                  45              


Met Ala Arg Gly Glu Asn Glu Lys Cys Leu Val Val Val Gly Glu Asp 
    50                  55                  60                  


Ser Arg Leu Gln Glu Leu Lys Gly Asn Gln Thr Glu Glu Asn Gly Leu 
65                  70                  75                  80  


Lys Val Lys Val Cys Pro Leu Ser Asn Glu Asn Cys Tyr Val Ile Arg 
                85                  90                  95      


Lys Ile Phe Pro Tyr Thr Asn Pro Gln Pro His Lys Gly Lys Asn Ile 
            100                 105                 110         


Thr Ile Gly Leu Gly Asp Arg Leu Gly Leu Ala Ser Pro Gly His Ile 
        115                 120                 125             


Arg Leu Ile Arg Asp Leu Asp Val Phe Pro Val Leu Ala Gln Gln Ser 
    130                 135                 140                 


Ile Arg Glu Leu Asn Leu Thr Gly Arg Thr Tyr Glu Asp Val Ile Ser 
145                 150                 155                 160 


Ala Ala Ala Trp Ala Val Phe Gln Glu Gly Tyr Thr Lys Gly Tyr Gly 
                165                 170                 175     


Ala Asp Gly Asp His Leu Lys Thr Ala Glu Glu Val Lys Met Ser Leu 
            180                 185                 190         


Asn Val Gly Met Thr Met Ile Thr Leu Asp Cys Ser Glu His Ile Asp 
        195                 200                 205             


Asn Ser Ala Ala His Ala Gly Leu Ser Glu Leu Arg Glu Lys Tyr Ser 
    210                 215                 220                 


Arg Phe Thr Glu Glu Glu Arg Glu Arg Trp Glu Arg Lys Tyr Leu Asn 
225                 230                 235                 240 


Arg Asp Val Lys Ile Gly Asn Tyr Ser Phe His Ile Ser Glu Glu Asp 
                245                 250                 255     


Leu Ile Arg Met Ala Cys Val Tyr Gly Gly Ala Ile Arg His Thr Leu 
            260                 265                 270         


Asp Ile Tyr His Asn Ile Ile Ala Lys Cys Gly Arg Pro Ile Asp Phe 
        275                 280                 285             


Glu Met Ser Ile Asp Glu Thr Leu Thr Pro Thr Ser Pro Ala Ser His 
    290                 295                 300                 


Tyr Phe Val Ala Gln Glu Leu Ile Asp Gly Gly Val Glu Ile Thr Ser 
305                 310                 315                 320 


Leu Ala Pro Arg Phe Cys Gly Glu Phe Gln Lys Gly Ile Asp Tyr Ile 
                325                 330                 335     


Gly Asp Leu Lys Gln Phe Thr Asp Glu Phe Ala Val His Ala Ala Ile 
            340                 345                 350         


Ala Asp His Phe Gly Tyr Lys Ile Ser Val His Ser Gly Ser Asp Lys 
        355                 360                 365             


Phe Lys Val Phe Pro Val Val Gly Glu Lys Thr Asn Gly Arg Tyr His 
    370                 375                 380                 


Leu Lys Thr Ala Gly Thr Asn Trp Leu Glu Ala Val Arg Val Ile Ala 
385                 390                 395                 400 


Arg His Lys Pro Asp Leu Tyr Arg Arg Met His Ala Phe Ala Leu Glu 
                405                 410                 415     


His Leu Glu Asp Ala Lys Lys Tyr Tyr His Ile Gly Ala Lys Val Glu 
            420                 425                 430         


Asn Ile Pro Ala Leu Glu Thr Leu Ala Asp Ser Glu Leu Pro Glu Leu 
        435                 440                 445             


Met Asn Arg Asp Asp Ser Arg Gln Val Met His Ile Thr Tyr Gly His 
    450                 455                 460                 


Ile Leu Gln Ala Lys Asp Glu Asn Gly Asn Pro Leu Phe Lys Asp Glu 
465                 470                 475                 480 


Leu Tyr Lys Val Leu Tyr Glu Tyr Glu Glu Glu Tyr Ala Asn Ala Leu 
                485                 490                 495     


Lys Lys His Ile Gly Arg His Leu Glu Gly Leu Gly Leu Leu 
            500                 505                 510 


<210>  329
<211>  488
<212>  PRT
<213>  Truepera radiovictrix

<400>  329

Met Pro Ser Gln Leu Pro Glu Pro Leu Pro Val Pro Pro Glu Ala Arg 
1               5                   10                  15      


Ala His Pro Ser Phe Arg Leu His Glu Gly Ala Ala Leu Trp Leu Ala 
            20                  25                  30          


Gly Ala Arg Leu Ala Val Leu Ala Pro Pro Glu His Pro Ala Leu Thr 
        35                  40                  45              


Arg Phe Arg Gly Glu Val Gln His Val Gly Asp His Arg Leu Leu Arg 
    50                  55                  60                  


Ala Glu Arg Arg Ala Glu Asn Ala Ala Ala Leu Arg Ala Leu Leu Pro 
65                  70                  75                  80  


Asp Leu Gln Pro Arg Pro Leu Gly Leu Val Thr Ser Ala Gly Phe Gly 
                85                  90                  95      


Asp Arg Leu Gly Val Ala Thr Pro Gly His Val Arg Ala Ala Gln Arg 
            100                 105                 110         


Tyr Gly Ala Gly Val Ala Pro Val Phe Ala Gln Gln Ser Ile Arg Glu 
        115                 120                 125             


Met Thr Arg Thr Gly Arg Thr Pro Gln Glu Val Leu Asp Asp Ala Thr 
    130                 135                 140                 


Trp Gly Ala Phe Ala Ala Gly Trp Arg Gly Ala Leu Gly Ala Asp Ala 
145                 150                 155                 160 


Asp His Gln Lys Thr Val Ala Asp Leu Glu Arg Cys Ala Ala Ala Gly 
                165                 170                 175     


Phe Thr Leu Phe Thr Val Asp Pro Ser Asp His Val Asp Asp Ser Ala 
            180                 185                 190         


His Gly Ala Pro Ala Ser Asp Leu Glu Ala Lys Val Ala Ala Leu Pro 
        195                 200                 205             


Trp Arg Glu Leu Glu Thr Thr Arg Ala Asp Phe Glu Arg Tyr Ala Gly 
    210                 215                 220                 


Arg Arg Leu Glu Leu Gly Asp Arg Glu Leu Val Leu Ala Arg Glu Ala 
225                 230                 235                 240 


Val Leu Arg Ala Gly Ala Lys Tyr Ala Arg Ala Val Leu His Val Ala 
                245                 250                 255     


Thr Leu Tyr Arg His Leu Glu Gly Lys Gly Ala Pro Phe Glu Leu Glu 
            260                 265                 270         


Val Ser Val Asp Glu Thr Ala Thr Pro Thr Ser His Ala Glu His Ala 
        275                 280                 285             


Val Val Ala Leu Glu Leu Arg Arg Leu Gly Val Arg Trp Val Gly Leu 
    290                 295                 300                 


Ala Pro Arg Phe Val Gly Arg Phe Glu Lys Gly Val Asp Tyr Arg Gly 
305                 310                 315                 320 


Asp Leu Gly Glu Leu Lys Ala Asp Leu Ala Gly His Ala Ala Leu Ala 
                325                 330                 335     


Arg Ser Leu Gly Pro Tyr Lys Leu Ser Leu His Ser Gly Ser Asp Lys 
            340                 345                 350         


Phe Ser Val Tyr Pro Leu Ile Ala Glu Ala Thr Gly Gly Met Val His 
        355                 360                 365             


Leu Lys Thr Ala Gly Thr Ser Tyr Leu Glu Ala Leu Arg Val Ala Ala 
    370                 375                 380                 


Gln Val Ala Pro Gly Leu Phe Arg Glu Ile Leu Thr Leu Gly Arg Glu 
385                 390                 395                 400 


Arg Phe Ala Val Asp Lys Gln Ser Tyr His Ile Ser Ala Ala Leu Ala 
                405                 410                 415     


Arg Val Ser Glu Ala Asp Thr Leu Thr Asp Asp Glu Leu Pro Arg Leu 
            420                 425                 430         


Leu Asp Asp Asp Asp Ala Arg Gln Val Leu His Val Thr Phe Gly Ser 
        435                 440                 445             


Ala Leu Asp Arg Tyr Arg Ala Pro Leu Leu Arg Val Leu Glu Ala His 
    450                 455                 460                 


Asp Glu Ala Tyr Gln Ala Gly Leu Ala Ala His Phe Ala Lys His Leu 
465                 470                 475                 480 


Thr Pro Phe Ala Glu Val Ala Pro 
                485             


<210>  330
<211>  485
<212>  PRT
<213>  Dictyoglomus turgidum

<400>  330

Met Leu Lys Leu Leu Asn Glu Ser Leu Lys Pro Leu Ser Ile Phe Ile 
1               5                   10                  15      


Tyr Ser Glu Ser Leu Arg Lys Ile Asn Asp Asp Leu Tyr Ile Phe Val 
            20                  25                  30          


Ala Lys Ile Lys Asp Leu Lys Lys Ile Gly Ile Val Lys Gln Asn Gln 
        35                  40                  45              


Ile Leu Tyr Phe Ser Ser Pro Tyr Phe Ser Glu Asp Lys Lys Ile Glu 
    50                  55                  60                  


Gly Thr Asn Phe Leu Val Asn Leu Tyr Pro Leu Asn Phe Glu Asn Tyr 
65                  70                  75                  80  


Gln Lys Leu Lys Glu Ile Ile Pro Ile Ser Pro Lys Val Cys Asp Lys 
                85                  90                  95      


Lys Ile Ser Phe Gly Thr Gly Asp Arg Leu Gly Leu Ile Thr Ser Ala 
            100                 105                 110         


Gln Leu Ser Ala Leu Lys Glu Tyr Asp Leu Phe Pro Ile Leu Ala Gln 
        115                 120                 125             


Gln Ser Pro Arg Glu Leu Ile Lys Thr Lys Arg Asp Phe Lys Asp Val 
    130                 135                 140                 


Leu Leu Lys Ser Ala Met Gly Val Leu Glu Thr Gly Tyr Thr Gly Lys 
145                 150                 155                 160 


Tyr Gly Ala Asp Ala Asp His Ile Lys Asp Glu Lys Tyr Leu Met Glu 
                165                 170                 175     


Ala Ile Asp Ala Gly Tyr Thr Met Tyr Thr Leu Asp Ile Ser Asp Phe 
            180                 185                 190         


Ile Glu Lys Ile Lys Asp Leu Ser Glu Lys Ala Leu Lys Glu Lys Tyr 
        195                 200                 205             


Glu Lys Val Ser Ser Phe Ser Lys Lys Ile Ile Asp Lys Tyr Ala Gly 
    210                 215                 220                 


Lys Arg Val Lys Ile Ser Asp Glu Glu Tyr Phe Glu Leu Ser Tyr Asn 
225                 230                 235                 240 


Glu Leu Cys Lys Ser Ala Ile Val Tyr Glu Lys Ala Leu Ser Phe Val 
                245                 250                 255     


Glu Met Val Tyr Glu Ile Leu Lys Ser Lys Leu Ser Glu Phe Asp Ile 
            260                 265                 270         


Glu Val Ser Ile Asp Glu Gly Glu Arg Asp Thr Thr Pro Glu Asp His 
        275                 280                 285             


Phe Phe Val Ala Gln Phe Leu His Asp Lys Gly Ile Asp Phe Lys Ser 
    290                 295                 300                 


Leu Ala Pro Lys Phe Pro Gly Glu Phe Gln Lys Gly Ile Asp Tyr Ile 
305                 310                 315                 320 


Gly Asp Ile Lys Glu Phe Glu Arg Ala Leu Lys Lys His Tyr Ala Leu 
                325                 330                 335     


Thr Lys Ala Leu Glu Gly Tyr Arg Leu Ser Leu His Ser Gly Ser Asp 
            340                 345                 350         


Lys Phe Ser Ile Tyr Lys Ile Phe Tyr Lys Ile Thr Glu Gly Asn Phe 
        355                 360                 365             


His Ile Lys Thr Ser Gly Thr Ser Trp Leu Glu Ala Val Lys Val Ile 
    370                 375                 380                 


Ala Lys Phe Phe Pro Asp Leu Phe Val Glu Leu Tyr Gln Ile Ala Leu 
385                 390                 395                 400 


Glu Asn Leu Glu Glu Ser Lys Lys Ala Tyr Lys Val Asn Ile Thr Lys 
                405                 410                 415     


Glu Glu Phe Pro Lys Glu Ile Lys Glu Asp Tyr Met Glu Phe Leu His 
            420                 425                 430         


Lys Asp Asn Val Arg Gln Leu Phe His Ile Ser Tyr Gly Val Leu Leu 
        435                 440                 445             


Asp Glu Lys Arg Lys Glu Ile Tyr Asp Leu Leu Asn Gln Lys Glu Lys 
    450                 455                 460                 


Glu His Tyr Gln Tyr Val Ser Glu Asn Ile Lys Lys His Leu Lys Asn 
465                 470                 475                 480 


Leu Phe Glu Glu Glu 
                485 


<210>  331
<211>  465
<212>  PRT
<213>  Caldilinea aerophila

<400>  331

Met Asn Asp Ala Val Tyr Ala Leu Gly Arg Ser Ser Arg Asn Gly Thr 
1               5                   10                  15      


Leu Gln Leu Ile Val Arg Gly Asn Ser Thr Gly Phe His Gly Glu Gln 
            20                  25                  30          


Gln Gly Asp Ala Leu Ile Cys Pro Leu Asp Ala Glu Asn Ala Arg Thr 
        35                  40                  45              


Leu Gln Glu Arg Leu Pro Trp Leu Arg Pro Gln Pro Leu Gly Asn Arg 
    50                  55                  60                  


Leu Ser Phe Gly Phe Gly Asp Arg Ile Gly Leu Ala Thr Pro Gly His 
65                  70                  75                  80  


Val Asp Ala Leu Arg Ser Ala Asp Pro Thr Gly Arg Ile Ala Pro Ile 
                85                  90                  95      


Phe Ala Gln Gln Ser Val Arg Glu Asn Gln Arg Leu Asn Arg Thr Pro 
            100                 105                 110         


Gln Glu Val Met Thr Ala Ala Val Trp Ser Leu Phe Ala Glu Asn Trp 
        115                 120                 125             


Arg Leu Pro Trp Gly Ala Asp Ala Asp His Val Lys Glu Pro Glu His 
    130                 135                 140                 


Leu Ala Pro Tyr Val Ala Ala Gly Tyr Thr Phe Tyr Thr Ile Asp Pro 
145                 150                 155                 160 


Ser Asp His Val Asp Asn Ala Ala His Thr Asp Asp Leu Ala Val Leu 
                165                 170                 175     


Arg Ser Lys Cys Glu Ala Leu Pro Trp Asp Ile Leu Glu Thr Thr Tyr 
            180                 185                 190         


Leu Ser Leu Cys Glu Asn Tyr Cys Gly Arg Thr Ile Val Ala Glu Lys 
        195                 200                 205             


Thr Thr Leu His Phe Asp Lys Glu Thr Leu Leu Arg Ala Leu Ala Lys 
    210                 215                 220                 


Tyr Gly Arg Ala Leu Ala His Thr Val Arg Ile Ala Ala Ala Leu Arg 
225                 230                 235                 240 


Thr Ala Leu Gly Gly Thr Ser Phe Asp Leu Glu Met Ser Val Asp Glu 
                245                 250                 255     


Thr Asp Thr Pro Thr Ser Ala His Glu His Phe Phe Ile Ala Asn Glu 
            260                 265                 270         


Leu Leu Arg Arg Asn Ile Pro Leu Val Ser Leu Ala Pro Arg Phe Val 
        275                 280                 285             


Gly Lys Phe Gln Lys Gly Val Asp Tyr Met Gly Asn Leu Ala Glu Phe 
    290                 295                 300                 


Glu Ala Glu Leu Ile Arg His Val Ala Val Met Arg His Phe His Cys 
305                 310                 315                 320 


Tyr Lys Leu Ser Val His Thr Gly Ser Asp Lys Phe Ser Ile Tyr Pro 
                325                 330                 335     


Ile Leu Ala Arg Cys Ala Gly Glu Asn Val His Ile Lys Thr Ala Gly 
            340                 345                 350         


Thr Ser Tyr Leu Glu Ala Leu Arg Val Ala Ala Leu Arg Ala Pro Asp 
        355                 360                 365             


Leu Phe Arg Gln Met Leu Glu Thr Gly Arg Thr Cys Tyr Glu Lys Asp 
    370                 375                 380                 


Lys Lys Thr Tyr Phe Leu Asp Cys Arg Pro Glu Arg Val Pro Pro Ala 
385                 390                 395                 400 


Ala Thr Leu Asp Asp Ala Asp Leu Pro Asn Leu Leu Asp Gln Phe Asp 
                405                 410                 415     


Ala Arg Gln Leu Leu His Val Thr Phe Gly Ser Ile Leu Thr Thr His 
            420                 425                 430         


Gly Ala Ala Leu Arg Asn Leu Leu Ala Thr Tyr Pro Asn Asp Tyr Arg 
        435                 440                 445             


Ser Ala Leu Arg Asp His Phe Ala Arg His Ile Gln Pro Phe Val Gln 
    450                 455                 460                 


Ala 
465 


<210>  332
<211>  474
<212>  PRT
<213>  Thermoflexus hugenholtzii

<400>  332

Met Met Leu Ser Pro Glu Ala Leu Ala Glu Gly Leu Arg Leu Tyr Gly 
1               5                   10                  15      


Leu His Leu Ile Val Gly Ser Ile Arg Glu Leu Pro Asp Gly Gly Ala 
            20                  25                  30          


Ile Phe Ala Ala Arg Gln Gly Ser Glu Arg Arg Ile Gly Trp Ile Gly 
        35                  40                  45              


Glu Thr Ser Pro Phe Pro Ala Pro Asp Pro Arg Met Ser Met Arg Val 
    50                  55                  60                  


Gln Glu His Leu Val Trp Ile His Pro Trp Thr Trp Ala His Tyr Arg 
65                  70                  75                  80  


Ile Leu Arg Glu Arg Leu Pro Ala Leu Ser Pro Thr Arg Cys Asp Arg 
                85                  90                  95      


Pro Ala Ser Phe Gly Ala Gly Asp Arg Leu Gly Met Ala Thr Ala Ala 
            100                 105                 110         


Gln Ile Ala Ala Leu Glu Arg Tyr Pro Val Phe Pro Val Leu Ala Gln 
        115                 120                 125             


Gln Ser Pro Arg Glu Leu Ala Arg Thr Gly Arg Asp Phe Arg Ser Val 
    130                 135                 140                 


Leu Leu Asp Ala Ala Trp Gly Val Phe Ala Ser Gly Phe Ala Gly Pro 
145                 150                 155                 160 


Phe Gly Ala Asp Ala Asp His Leu Gln Asp Asp Glu Gln Leu Arg Ala 
                165                 170                 175     


Ala Ala Glu Ala Gly Tyr Ser Leu Tyr Thr Phe Asp Leu Arg Arg Ala 
            180                 185                 190         


Leu Ala Arg Gly Pro Arg Pro Trp Glu Ala Leu Ser Pro Leu Ala Arg 
        195                 200                 205             


Ser Val Val Ala Glu Leu Ala Asp Arg Arg Val Glu Ala Pro Gln Gly 
    210                 215                 220                 


Pro Arg Thr Leu Glu Glu Ser Ala Leu Arg Ala Ala Ala Cys Arg Tyr 
225                 230                 235                 240 


Glu Pro Ala Leu Glu Glu Val Val Arg Gly Ala Glu Ile Leu Arg Asp 
                245                 250                 255     


Gln Gly Ile Asp Ala Asp Leu Glu Val Ser Val Asp Glu Thr Glu Glu 
            260                 265                 270         


Glu Thr Thr Pro Glu Ala His Ala Phe Ile Ala Val Tyr Leu Gln Arg 
        275                 280                 285             


Arg Gly Val Ala Leu Trp Ser Leu Ala Pro Arg Phe Pro Gly Val Phe 
    290                 295                 300                 


Glu Lys Ala Val Asp Tyr Glu Gly Glu Val Glu Arg Phe Ala Gln Ala 
305                 310                 315                 320 


Ala Ala Leu His Thr Ala Val Ala Arg Thr Phe Gly Gly His Arg Leu 
                325                 330                 335     


Ser Leu His Ser Gly Ser Glu Lys Phe Arg Ile Leu Pro Val Phe Arg 
            340                 345                 350         


Glu Ala Thr Gly Gly Arg Phe His Val Lys Thr Ser Gly Thr Thr Trp 
        355                 360                 365             


Leu Gln Ala Val Arg Val Val Ala Arg Ala Val Pro Ala Leu Phe Ala 
    370                 375                 380                 


Glu Leu Tyr Ala Ile Ala Arg Ala His Leu Glu Glu Ser Arg Arg Asp 
385                 390                 395                 400 


Tyr Pro Ile Ala Leu Gln Pro Glu Ala Leu Pro Pro Ala Leu Pro Asp 
                405                 410                 415     


Asp Pro Glu Ala Ala Leu Ala Asp Arg Ala Val Arg Gln Leu Phe His 
            420                 425                 430         


Ile Ser Tyr Gly Val Leu Leu Arg Glu Arg Gly Pro Ala Ile Arg Ala 
        435                 440                 445             


Leu Leu Glu Ala His Glu Ala Glu His Phe Thr Ala Val Arg Glu Asn 
    450                 455                 460                 


Leu Glu Arg His Leu Glu Ala Leu Leu Lys 
465                 470                 


<210>  333
<211>  483
<212>  PRT
<213>  Thermoanaerobacterium thermosaccharolyticum

<400>  333

Met Ile Gly Asn Val Leu Ser Thr Leu Glu Glu Asn Gly Phe Lys Val 
1               5                   10                  15      


Tyr Pro Asp Ser Leu Arg Lys Leu Gly Glu Asn Ile Tyr Ile Phe Val 
            20                  25                  30          


Val Lys Arg Gln Asn Glu Lys Met Val Gly Ile Leu Ser Ser Ser Asp 
        35                  40                  45              


Val Lys Leu Asn Gly Ala Tyr Phe Ser Glu Asp Lys Asn Val Ser Asp 
    50                  55                  60                  


Lys Leu Arg Leu Asn Ile Tyr Pro Phe Thr Phe Glu Asn Tyr Val Thr 
65                  70                  75                  80  


Leu Asn Gly Lys Phe His Ile Gly Pro Thr Val Cys Arg Gly Asn Ser 
                85                  90                  95      


Ser Phe Gly Thr Gly Asp Arg Leu Gly Leu Val Thr Ala Ala Gln Leu 
            100                 105                 110         


Thr Ala Leu Lys Lys Tyr Asp Val Phe Pro Ile Leu Ala Gln Gln Ser 
        115                 120                 125             


Pro Arg Glu Leu Ile Lys Thr Asn Arg Asp Phe Lys Asp Val Leu Leu 
    130                 135                 140                 


Lys Val Val Leu Gly Val Leu Glu Thr Gly Tyr Ile Gly His Phe Gly 
145                 150                 155                 160 


Ala Asp Ala Asp His Ile Lys Asp Glu Tyr Tyr Leu Leu Glu Gly Ile 
                165                 170                 175     


Asn Ala Gly Tyr Thr Met Tyr Thr Leu Asp Leu Ser Glu Gln Leu Ile 
            180                 185                 190         


Asp Ile Ser Ser Leu Asn Pro Ser Glu Met Arg Asn Lys Ala Gln Glu 
        195                 200                 205             


Leu Ser Gln Val Ser Lys Asp Ile Ile Lys Asp Phe Ser Gly Lys Lys 
    210                 215                 220                 


Leu Asp Ile Ile Ser Asp Ser Gly Tyr Val Val Ser Glu Glu Glu Leu 
225                 230                 235                 240 


Tyr Lys Ser Ala Val Ala Tyr Glu Asn Ala Met Lys Phe Val Asp Lys 
                245                 250                 255     


Val Asn Asn Ile Leu Lys Glu Lys Leu Ser Asp Phe Asp Met Glu Ile 
            260                 265                 270         


Ser Ile Asp Glu Gly Gly Lys Val Thr Thr Leu Glu Asp His Leu Tyr 
        275                 280                 285             


Val Ala Glu Tyr Leu His Arg Asn Gly Ile Asp Phe Phe Ser Ile Ala 
    290                 295                 300                 


Pro Lys Phe Pro Gly Glu Phe Glu Lys Ala Val Asp Tyr Ile Gly Asp 
305                 310                 315                 320 


Leu Asp Glu Phe Leu Leu Glu Leu Lys Lys His Tyr Gln Leu Ser Arg 
                325                 330                 335     


Met Ile Gly Gly Tyr Lys Ile Ser Leu His Ser Gly Ser Asp Lys Phe 
            340                 345                 350         


Ser Ile Tyr Arg Ile Phe Ser Asp Ile Thr Glu Lys Asn Phe His Ile 
        355                 360                 365             


Lys Thr Ser Gly Thr Ser Trp Leu Gln Ala Ile Asn Leu Ile Tyr Asn 
    370                 375                 380                 


Tyr Asp Lys Glu Phe Tyr Arg Glu Leu Tyr Lys Ile Ala Leu Glu Asn 
385                 390                 395                 400 


Leu Glu Glu Ser Lys Lys Ser Tyr Lys Val Leu Ile Lys Arg Glu Asp 
                405                 410                 415     


Phe Cys Lys Glu Pro Glu Leu Asn Asn Pro Lys Phe Ile Leu Lys Pro 
            420                 425                 430         


Glu Ile Lys Gln Leu Phe His Ile Ser Phe Gly Val Leu Leu Asn Leu 
        435                 440                 445             


Lys Arg Lys Glu Ile Val Asp Phe Leu Asn Lys Tyr Glu Glu Glu His 
    450                 455                 460                 


Tyr Lys Met Val Ser Lys Asn Ile Asp Asn His Leu Lys Glu Ile Phe 
465                 470                 475                 480 


Tyr Lys Asn 
            


<210>  334
<211>  385
<212>  PRT
<213>  Petrotoga mobilis

<400>  334

Met Phe Thr Ile Leu Pro Lys Lys Gly Ile Ser Leu Gly Leu Gly Asp 
1               5                   10                  15      


Arg Ile Gly Ile Ala Thr Pro Gly His Ile Lys Val Ala Lys Lys Tyr 
            20                  25                  30          


Asn Phe Phe Pro Val Phe Ala Gln Gln Ser Ile Arg Glu Leu Asn Phe 
        35                  40                  45              


Thr Gly Arg Thr Phe Thr Asp Val Arg Lys Asp Val Leu Asn Ala Leu 
    50                  55                  60                  


Val Glu Glu Asn Tyr Val Gly Asn Ser Gly Phe Asp Gly Asp His Leu 
65                  70                  75                  80  


Lys Ser Asp Glu Glu Ile Gln Tyr Ala Leu Asp Ser Gly Ile Thr Met 
                85                  90                  95      


Leu Thr Leu Asp Cys Ser Glu His Met Asn Lys Asp Ser Ser Ile Lys 
            100                 105                 110         


Asp Gln Ile Phe Glu Gln Phe Tyr Asn Lys Ser Phe Phe Val Asn Asp 
        115                 120                 125             


Met Pro Ile Glu Tyr Ser Asp Lys Asn Glu Leu Asn Lys Ile Val Ser 
    130                 135                 140                 


Ile Tyr Ala Ser Val Ile Glu Arg Val Ile Asp Val Trp Asn Lys Phe 
145                 150                 155                 160 


Pro Lys Val Asn Lys Lys Glu Val Thr Phe Glu Val Ser Val Asp Glu 
                165                 170                 175     


Thr Asp Val Pro Thr Asp Glu Lys Thr His Phe Leu Ile Ser Lys Tyr 
            180                 185                 190         


Ile Tyr Asp Glu Gly Val Lys Ile Asp Thr Leu Ala Pro Arg Phe Pro 
        195                 200                 205             


Gly Glu Phe Gln Lys Ala Ile Asp Tyr Ile Gly Asn Ile Gln Glu Phe 
    210                 215                 220                 


Lys Lys Ser Leu Ile Lys Gln Asp Lys Ile Ala Lys Tyr Phe Gly Tyr 
225                 230                 235                 240 


Arg Leu Ser Ile His Ser Gly Ser Asp Lys Phe Ser Ile Tyr Pro Ile 
                245                 250                 255     


Ile Gly Glu Val Thr Gln Gly Asn Tyr His Leu Lys Thr Ser Gly Thr 
            260                 265                 270         


Ser Tyr Leu Glu Ala Ile Lys Val Val Ala Gln Lys Asp Pro Glu Phe 
        275                 280                 285             


Phe Lys Lys Ile Trp Gln Thr Cys Leu Asp Lys Arg Glu Glu Met Asp 
    290                 295                 300                 


Lys Tyr Tyr His Leu Ser Cys Asp Pro Phe Ser Val Pro Lys Asp Leu 
305                 310                 315                 320 


Ser Pro Thr Glu Tyr Leu Gln Asn Pro Asp Ala Arg Gln Thr Leu His 
                325                 330                 335     


Val Ser Tyr Met Phe Val Leu Asn Pro Gln Tyr Asp Phe Arg Glu Lys 
            340                 345                 350         


Phe Phe Glu Ile Leu Thr Lys Tyr Gln Asn Glu Tyr His Glu Asn Val 
        355                 360                 365             


Ala Asn His Ile Glu Lys His Val Lys Glu Leu Lys Ile Glu Glu Lys 
    370                 375                 380                 


Ser 
385 


<210>  335
<211>  426
<212>  PRT
<213>  Spirochaeta thermophila

<400>  335

Met Ala Thr Pro Gly Ser Leu Ser Phe Pro Arg Tyr Ser Ile Gly Thr 
1               5                   10                  15      


Gly Asp Arg Phe Gly His Glu Ala Glu Ala Gln Leu Arg Ala Val Ile 
            20                  25                  30          


Glu Ala Gly Arg Leu Gly Arg Ala Leu Gly Ile Val Trp Asn Lys Ser 
        35                  40                  45              


Tyr Arg Glu His Thr Ile Ile Gly Ser Arg Pro Glu Asp Val Arg Arg 
    50                  55                  60                  


Met Ala Asp Arg Ala Val Ser Ser Leu Gly Trp Glu Gly Pro Tyr Phe 
65                  70                  75                  80  


Val Asp Ala Asp His Ile Thr Thr Lys Thr Val Asp Leu Phe Leu Asp 
                85                  90                  95      


Ser Ala Asp Phe Phe Thr Ile Asp Val Ala Glu Ala Ile Gly Lys Gly 
            100                 105                 110         


Glu Val Ser Pro Gln Glu Glu Glu Asp Leu Leu Ala Ser Leu Gly Asp 
        115                 120                 125             


Leu Leu Asn Arg Glu Leu Ala Ile Pro Gly Leu Ser Ser Pro Leu Ala 
    130                 135                 140                 


Ile Ser Glu Glu Thr Ala Arg Gly Thr Ile Arg Ala Tyr Trp Pro Ala 
145                 150                 155                 160 


Val Arg Glu Ala Ala Arg Ile Tyr Arg Arg Ile Glu Gln Gly Ala Ser 
                165                 170                 175     


Arg Pro Phe Val Val Glu Val Ser Met Asp Glu Thr Asp Glu Pro Gln 
            180                 185                 190         


Arg Pro Pro Glu Leu Leu Leu Ile Leu Ala Met Ile Arg Lys Ala Gly 
        195                 200                 205             


Ile Pro Ala Arg Thr Ile Ala Pro Lys Phe Ser Gly Ala Phe Tyr Lys 
    210                 215                 220                 


Gly Val Asp Tyr Val Gly Asp Pro His Thr Phe Ala Arg Glu Phe Glu 
225                 230                 235                 240 


Asp Asp Leu Cys Val Val Arg Tyr Ala Arg Glu Gln Phe Ala Leu Pro 
                245                 250                 255     


Glu Gly Leu Lys Leu Ser Val His Ser Gly Ser Asp Lys Phe Ser Leu 
            260                 265                 270         


Tyr Pro Leu Val Arg Glu Ile Leu Ser Arg His Pro Gln Glu Gly Val 
        275                 280                 285             


His Leu Lys Thr Ala Gly Thr Thr Trp Leu Glu Glu Val Ala Gly Leu 
    290                 295                 300                 


Ala Glu Ala Gly Gly Glu Ala Leu Ala Leu Ala Lys Glu Ile Ala Leu 
305                 310                 315                 320 


Thr Cys Tyr Ser Met Ile Glu Glu Leu Cys Ala Pro Tyr Ala Ala Val 
                325                 330                 335     


Ile Asp Ile Asp Pro Glu Arg Leu Pro Ser Pro Gly Glu Ile Glu Glu 
            340                 345                 350         


Trp Ser Ser Gly Arg Phe Val Glu Ala Leu Glu His Asp Pro Ser Asn 
        355                 360                 365             


Pro Ser Tyr Asn Arg Asp Phe Arg Gln Leu Ile His Val Gly Tyr Lys 
    370                 375                 380                 


Val Ala Ala Gln Met Gly Glu Arg Phe His Gln Ala Leu Glu Ala His 
385                 390                 395                 400 


Arg Glu Val Ile Ala Ala Arg Val Thr Arg Asn Leu Leu Glu Arg His 
                405                 410                 415     


Ile Ile Pro Leu Phe Pro Gly Asp Ile Pro 
            420                 425     


<210>  336
<211>  480
<212>  PRT
<213>  Thermofilum pendens

<400>  336

Met Leu His Val Tyr Leu Gly Lys Ile Pro Arg Pro Gly Phe Gly Ile 
1               5                   10                  15      


Arg Ile Pro Glu Val Val Ala Pro Pro Leu Leu Ser Ala Phe Lys Ser 
            20                  25                  30          


Leu Gly Met Thr Gly Ser Leu Met Leu Ser Phe Asn Arg Glu Thr Ala 
        35                  40                  45              


Pro Ala Glu Tyr Ile Glu Ser Ser Asp Pro Arg Leu Phe Tyr Phe Gly 
    50                  55                  60                  


His Thr Gly Thr Ser Ile Gly Gly Phe Ile Arg Ser Val Lys Glu Tyr 
65                  70                  75                  80  


Ser Lys Ala Leu Ser Val Pro Val Glu Val Glu Ala Asp His Val Ser 
                85                  90                  95      


Ile Leu Gly Ser Val Glu Arg Ala Leu Lys Lys Ile Ala Gly Val Pro 
            100                 105                 110         


Val Glu Glu Pro Leu Ser Glu Glu Glu Val Ser Trp Ser Ile Gly Tyr 
        115                 120                 125             


Val Glu Arg Glu Leu Arg Glu Ala Ala Glu Ala Gly Gly Val Asp Phe 
    130                 135                 140                 


Val Thr Ile Asp Thr Cys Glu Leu Ile Asp Tyr Ser Tyr Asp Lys Val 
145                 150                 155                 160 


Gly Ala Glu Glu Val Ala Ala Ala Tyr Glu Glu Val Phe Asp Gly Asp 
                165                 170                 175     


Glu Arg Arg Ala Leu Glu Glu Arg Tyr Glu Gly Val His Tyr Phe Leu 
            180                 185                 190         


Gly Gly Asp Arg Val Val Ala Val Arg Leu Ser Arg Glu Asp Val Ala 
        195                 200                 205             


Arg Leu Ala Val Lys Tyr Arg Arg Ser Leu Asp Tyr Ala Glu Arg Ile 
    210                 215                 220                 


Tyr Arg Ala Ala Arg Glu Ala Met Gly Val Glu Leu Gly Phe Glu Val 
225                 230                 235                 240 


Ala Phe Asp Glu Thr Pro Gly Val Ser Glu Ala Arg Glu Val Phe Phe 
                245                 250                 255     


Tyr Leu Ser Glu Leu Leu Arg Arg Gly Leu Arg Val Asp Phe Ile Ala 
            260                 265                 270         


Pro Asn Val Gly Phe Arg Lys Arg Glu Asp Tyr Ser Gly Asp Leu His 
        275                 280                 285             


Ala Leu Tyr Glu Arg Leu Arg Asn Leu His Ala Val Val Ser Ser Met 
    290                 295                 300                 


Asn Ala Tyr Leu Ser Ile His Ser Gly Ser Gly Ser His Pro Tyr Ser 
305                 310                 315                 320 


Asp Lys Gly Phe Gly Val Trp Gly Val Val Gly Arg Ala Thr Gly Gly 
                325                 330                 335     


Ala Val Lys Tyr Lys Met Ser Gly Val Leu Val Gln Leu Leu Leu Glu 
            340                 345                 350         


Val Met Ala Ser Tyr Pro Pro Gly Ser Glu Thr Arg Arg Leu Tyr Glu 
        355                 360                 365             


Glu Ile Tyr Ser Glu Val Val Glu His Leu Arg Trp Val Val Lys Ala 
    370                 375                 380                 


Lys Ala Ser Leu Tyr Ser Pro Glu Leu Glu Thr Leu Leu Lys Arg Tyr 
385                 390                 395                 400 


Glu Ala Ala Gln Asp Arg Phe Asp Pro Arg Ala Asp Val Phe Arg His 
                405                 410                 415     


Tyr Phe Tyr Val Phe Gln Ala Leu Arg Asp Glu Gly Gly Ala Arg Arg 
            420                 425                 430         


Leu Arg Glu Arg Leu Val Glu His Tyr Arg Glu Asn Pro Gly Leu Arg 
        435                 440                 445             


Glu Arg Tyr Glu Lys Glu Leu Arg Gly Leu Val Glu Arg Leu Ala Ser 
    450                 455                 460                 


Gln Leu Gly Tyr Ala Gly Asn Ala Tyr Arg Tyr Arg Val Val Tyr Ala 
465                 470                 475                 480 


<210>  337
<211>  519
<212>  PRT
<213>  Rhodothermus marinus

<400>  337

Met Val Thr Val Leu Gln Thr Leu Leu Gln Arg Pro Arg Pro Leu Ala 
1               5                   10                  15      


Glu Ile Asp Arg Ala Ala Leu Ala Arg Phe Leu Thr Asp Leu Ile Arg 
            20                  25                  30          


Gln Gln Val Tyr Pro Ala Ser Leu Glu Pro Thr Ser Glu Gly Val Phe 
        35                  40                  45              


Phe Leu Ala Arg Asp Gly Arg Glu Lys Arg Leu Gly Ile Leu Ser Glu 
    50                  55                  60                  


Ala Gly Leu His Asp Phe Glu Gly Ala Arg His Gln Leu Ser Leu Asp 
65                  70                  75                  80  


Gly Arg Thr Leu Ile Phe Gln Ser Cys Pro Leu Thr Ala Ala Asn Ala 
                85                  90                  95      


Arg Ala Leu Arg Gln His Leu Ala Trp Thr Ala Pro Arg Pro Leu Gly 
            100                 105                 110         


Leu Arg Ala Ser Val Gly Cys Gly Asp Arg Leu Gly Leu Ala Thr Pro 
        115                 120                 125             


Gly His Val Arg Ala Val Arg Lys His Lys Leu Ala Pro Val Phe Ala 
    130                 135                 140                 


Gln Gln Ser Ile Arg Glu Met Thr Arg Thr Gly Arg Thr Pro Gln Gln 
145                 150                 155                 160 


Val Leu Asp Glu Ala Met Trp Gly Val Phe Gln Glu Gly Trp Arg Gln 
                165                 170                 175     


Gly Tyr Gly Ala Asp Ala Asp His Leu Lys Thr Glu Glu Asp Ala Asp 
            180                 185                 190         


Arg Cys Ile Glu Ala Gly Phe Thr Phe Phe Thr Ile Asp Pro Ser Ala 
        195                 200                 205             


Tyr Val Asp Asn Glu Val Asp Thr Ala Asp Ala Ala Thr Leu Glu Ala 
    210                 215                 220                 


Lys Val Ala Ala Leu Pro Trp Asp Ala Leu Glu Thr Thr Leu Ala Asp 
225                 230                 235                 240 


Leu Arg Arg Ala Tyr Leu Gly Gln His Phe Gln Val Gly Pro Tyr Glu 
                245                 250                 255     


Leu Ser Phe Glu Glu Arg Thr Leu Leu Gln Ala Leu Ala Lys Tyr Gly 
            260                 265                 270         


Gly Ala Ile Ala His Thr Ala Arg Val Tyr Arg His Ile Ala Gly Arg 
        275                 280                 285             


Met Gly Asn Arg Pro Phe Glu Leu Glu Met Ser Val Asp Glu Thr Glu 
    290                 295                 300                 


Val Pro Thr Ser Pro Ala Glu His Phe Phe Val Ala Arg Glu Leu Gln 
305                 310                 315                 320 


Arg Leu Gly Val Arg Trp Ile Ser Leu Ala Pro Arg Phe Val Gly Arg 
                325                 330                 335     


Leu Glu Lys Gly Val Asp Tyr Ile Gly Asp Leu Glu Glu Phe Glu Ala 
            340                 345                 350         


His Leu Lys Leu His Val Ala Ile Ala Arg Thr Leu Gly Pro Tyr Lys 
        355                 360                 365             


Leu Ser Leu His Ser Gly Ser Asp Lys Phe Ala Leu Tyr Pro Leu Phe 
    370                 375                 380                 


Ala Arg His Ala Gly Glu Leu Phe His Leu Lys Thr Ala Gly Thr Ser 
385                 390                 395                 400 


Tyr Leu Glu Ala Leu Arg Ala Val Ala Glu Leu Asp Pro Pro Leu Phe 
                405                 410                 415     


Arg Glu Ile Leu Asp Phe Ala Arg Asp Arg Tyr Glu Thr Asp Arg Ala 
            420                 425                 430         


Thr Tyr His Val Ser Ala Leu Leu Glu Arg Val Pro Lys Ala Ser Asp 
        435                 440                 445             


Val Pro Asp Asp Ala Leu Pro Ala Leu Leu Glu Gln Phe Asp Thr Arg 
    450                 455                 460                 


Gln Val Leu His Val Thr Phe Gly Ser Val Leu Thr Ala Thr Asp Ala 
465                 470                 475                 480 


Asp Gly Arg Pro Arg Phe Arg Asp Arg Leu Leu Ala Val Leu Gln Glu 
                485                 490                 495     


Asn Glu Glu Thr Tyr Tyr Arg Leu Leu Glu Ala His Phe Asp Arg His 
            500                 505                 510         


Leu Ala Pro Phe Asp Ala Lys 
        515                 


<210>  338
<211>  485
<212>  PRT
<213>  Dictyoglomus thermophilum

<400>  338

Met Leu Asn Leu Leu Glu Glu Leu Leu Lys Pro Phe Ser Ile Phe Val 
1               5                   10                  15      


Tyr Pro Gln Ser Leu Arg Lys Ile Asn Glu Glu Leu Tyr Ile Phe Val 
            20                  25                  30          


Ala Lys Ile Asn Asn Thr Lys Asn Ile Gly Ile Ile Lys Gln Asn Gln 
        35                  40                  45              


Ser Ile Tyr Phe Ser Asn Pro Tyr Phe Ser Glu Asp Lys Lys Ile Glu 
    50                  55                  60                  


Lys Thr Gly Phe Ser Val Asn Ile Tyr Pro Leu Asn Phe Glu Asn Tyr 
65                  70                  75                  80  


Gln Lys Leu Lys Glu Ile Ile Pro Ile Asn Pro Lys Thr Cys Asn Lys 
                85                  90                  95      


Lys Ile Ser Phe Gly Thr Gly Asp Arg Leu Gly Leu Val Thr Ser Ala 
            100                 105                 110         


Gln Leu Ser Val Leu Lys Asp Tyr Asn Leu Phe Pro Ile Leu Ala Gln 
        115                 120                 125             


Gln Ser Pro Arg Glu Leu Ile Lys Thr Lys Arg Asp Phe Lys Asp Val 
    130                 135                 140                 


Leu Leu Lys Ser Val Ile Gly Val Leu Glu Ile Gly Tyr Thr Asp Ser 
145                 150                 155                 160 


Tyr Gly Ala Asp Ala Asp His Ile Lys Asp Glu Lys Tyr Leu Met Glu 
                165                 170                 175     


Ala Ile Asp Ala Gly Tyr Thr Met Tyr Thr Leu Asp Ile Ser Asp Phe 
            180                 185                 190         


Ile Glu Arg Ile Glu Asn Leu Thr Ser Lys Glu Ile Arg Glu Lys Tyr 
        195                 200                 205             


Glu Lys Ile Ser Ser Phe Ser Lys Lys Ile Ile Glu Lys Tyr Ala Gly 
    210                 215                 220                 


Lys Lys Ile Lys Ile Ser Asn Glu Glu Tyr Phe Glu Leu Ser Tyr Asp 
225                 230                 235                 240 


Glu Leu Cys Lys Ser Ala Ile Val Tyr Glu Lys Ala Leu Ser Phe Val 
                245                 250                 255     


Glu Met Val Tyr Glu Ile Leu Arg Ser Lys Leu Leu Glu Phe Asp Ile 
            260                 265                 270         


Glu Val Ser Ile Asp Glu Gly Glu Arg Asp Thr Thr Pro Glu Asp His 
        275                 280                 285             


Phe Phe Val Val Gln Phe Leu His Glu Lys Gly Ile Asp Phe Lys Ser 
    290                 295                 300                 


Leu Ala Pro Lys Phe Pro Gly Glu Phe Gln Lys Gly Ile Asp Tyr Ile 
305                 310                 315                 320 


Gly Asp Ile Lys Lys Phe Glu Asn Glu Leu Lys Lys Gln Tyr Ala Leu 
                325                 330                 335     


Thr Lys Ala Leu Glu Gly Tyr Arg Leu Ser Leu His Ser Gly Ser Asp 
            340                 345                 350         


Lys Phe Ser Ile Tyr Lys Ser Phe Tyr Lys Ile Thr Glu Gly Asn Phe 
        355                 360                 365             


His Ile Lys Thr Ser Gly Thr Ser Trp Leu Glu Ala Val Lys Thr Ile 
    370                 375                 380                 


Ala Arg Tyr Ser Pro Asp Leu Phe Leu Glu Leu Tyr His Ile Ala Leu 
385                 390                 395                 400 


Glu Asn Leu Glu Glu Ser Lys Lys Ala Tyr Lys Val Ser Ile Thr Lys 
                405                 410                 415     


Glu Glu Phe Pro Lys Glu Ile Lys Glu Asp Tyr Ile Glu Phe Leu Lys 
            420                 425                 430         


Lys Pro Asn Val Arg Gln Leu Phe His Ile Ser Tyr Gly Val Leu Leu 
        435                 440                 445             


Asp Glu Lys Arg Glu Glu Ile Tyr Glu Ile Leu Asn Lys Asn Glu Lys 
    450                 455                 460                 


Glu His Tyr Gln Tyr Val Ser Glu Asn Ile Arg Lys His Leu Lys Asn 
465                 470                 475                 480 


Leu Phe Glu Glu Glu 
                485 


<210>  339
<211>  483
<212>  PRT
<213>  Thermoanaerobacter siderophilus

<400>  339

Met Lys Glu Glu Leu Ser Asp Tyr Leu Leu Lys Asn Ser Phe Leu Leu 
1               5                   10                  15      


Tyr Pro Asp Ser Phe Arg Arg Leu Arg Glu Asp Val Tyr Ile Phe Val 
            20                  25                  30          


Ala Lys Lys Asp Ser Asp Lys Lys Ile Gly Leu Leu Thr Asn Gly Asn 
        35                  40                  45              


Phe Lys Leu Ser Ser Pro His Phe Ala Glu Asp Lys Tyr Val Glu Glu 
    50                  55                  60                  


Leu Gly Phe Tyr Ile Asn Leu Tyr Pro Leu Thr Tyr Glu Asn Tyr Leu 
65                  70                  75                  80  


Ile Leu Lys Asp Asn Phe Gly Ile Ser Pro Val Thr Cys Lys Glu Lys 
                85                  90                  95      


Ala Ser Phe Gly Thr Gly Asp Arg Leu Gly Leu Ala Thr Pro Ala His 
            100                 105                 110         


Ile Lys Ala Leu Lys Asn Tyr Asn Val Phe Pro Val Leu Ala Gln Gln 
        115                 120                 125             


Ser Pro Arg Glu Leu Val Lys Thr His Arg Asp Phe Lys Asp Val Phe 
    130                 135                 140                 


Leu Lys Val Ile Leu Gly Val Leu Glu Ala Gly Tyr Ala Gly Gly Tyr 
145                 150                 155                 160 


Gly Ala Asp Ala Asp His Ile Lys Asp Glu Lys Tyr Leu Ile Glu Ala 
                165                 170                 175     


Ile Asp Ala Gly Tyr Thr Met Tyr Thr Leu Asp Leu Ser Asp Leu Leu 
            180                 185                 190         


Val Lys Ile Ser Asp Met Pro Lys Ser Gln Leu Lys Glu Lys Ala Gln 
        195                 200                 205             


Ser Leu Ser Ser Gln Ser Arg Glu Ile Ile Asp Arg Phe Lys Gly Lys 
    210                 215                 220                 


Lys Phe Ser Ile Ser Thr Asp Glu Asp Phe Ala Val Ser Glu Asp Glu 
225                 230                 235                 240 


Leu Tyr Lys Ser Ala Leu Thr Tyr Glu Lys Ala Met Lys Phe Val Glu 
                245                 250                 255     


Lys Val Tyr Gly Ile Leu Lys Asp Arg Leu Gln His Phe Asp Leu Glu 
            260                 265                 270         


Ile Ser Ile Asp Glu Gly Glu Lys Asp Thr Thr Val Glu Asp His Ile 
        275                 280                 285             


Phe Val Ala Glu Tyr Leu His Arg Lys Gly Ile Asp Phe Trp Ser Leu 
    290                 295                 300                 


Ala Pro Lys Phe Pro Gly Glu Phe Gln Lys Ala Ile Asp Tyr Lys Gly 
305                 310                 315                 320 


Asp Ile Lys Lys Phe Thr Ser Gly Leu Lys Lys His Tyr Phe Leu Ser 
                325                 330                 335     


Lys Lys Leu Gly Gly Tyr Lys Leu Ser Leu His Ser Gly Ser Asp Lys 
            340                 345                 350         


Phe Ser Ile Tyr Lys Ile Phe Asn Glu Ile Thr Glu Gly Asn Phe His 
        355                 360                 365             


Ile Lys Thr Ser Gly Thr Ser Trp Leu Gln Ala Ile Asn Ile Ile Phe 
    370                 375                 380                 


Glu Arg Asp Lys Asp Leu Phe Asn Asp Leu Tyr Lys Ile Ala Leu Asp 
385                 390                 395                 400 


Asn Leu Glu Glu Ser Lys Lys Ala Tyr Lys Val Leu Ile Asp Arg Asp 
                405                 410                 415     


Asp Phe Pro Gln Thr Ile Gln Thr Glu Asp Ser Gln Ile Leu Leu Lys 
            420                 425                 430         


Pro Glu Ile Lys Gln Leu Phe His Ile Ser Tyr Gly Val Leu Leu Asp 
        435                 440                 445             


Glu Arg Arg Lys Glu Ile Tyr Glu Val Leu Asn Lys Tyr Glu Glu Glu 
    450                 455                 460                 


His Tyr Glu Phe Val Ser Lys Asn Ile Glu Asn His Leu Lys Glu Ile 
465                 470                 475                 480 


Phe Asn Ile 
            


<210>  340
<211>  482
<212>  PRT
<213>  Thermoanaerobacter mathranii

<400>  340

Met Val Glu Lys Ser Ile Leu Glu Lys Leu Thr Asp Phe Leu Leu Asn 
1               5                   10                  15      


His Ser Phe Val Leu Tyr Pro Asn Ser Leu Arg Lys Leu Lys Glu Asp 
            20                  25                  30          


Thr Tyr Ile Phe Val Ala Lys Lys Asp Ala Asp Lys Lys Ile Gly Ile 
        35                  40                  45              


Leu Thr Lys Glu Asn Phe Lys Leu Thr Ser Pro Tyr Phe Val Glu Asp 
    50                  55                  60                  


Lys Asn Val Lys Glu Ile Asp Phe Tyr Leu Asn Leu Tyr Pro Leu Ser 
65                  70                  75                  80  


Phe Glu Asn Tyr Leu Ile Leu Lys Asn Phe Gly Ile Ser Pro Thr Pro 
                85                  90                  95      


Cys Arg Gln Lys Ser Ser Phe Gly Thr Gly Asp Arg Leu Gly Leu Val 
            100                 105                 110         


Thr Pro Ala His Ile Val Ala Leu Lys Glu Tyr Pro Val Phe Pro Val 
        115                 120                 125             


Leu Ala Gln Gln Ser Pro Arg Glu Leu Glu Lys Thr His Arg Asp Phe 
    130                 135                 140                 


Lys Asp Ala Leu Leu Lys Val Ile Leu Gly Val Leu Glu Ala Gly Tyr 
145                 150                 155                 160 


Thr Gly Glu Phe Gly Ala Asp Ala Asp His Ile Lys Asp Glu Lys Tyr 
                165                 170                 175     


Leu Leu Arg Ala Ile Glu Ala Gly Tyr Thr Met Tyr Thr Leu Asp Val 
            180                 185                 190         


Ser Glu Leu Leu Thr Lys Ile Leu Asp Ile Ser Ser Asn Gln Val Met 
        195                 200                 205             


Gln Ile Ser Pro Gln Ser Lys Glu Ile Ile Glu Ala Phe Lys Gly Lys 
    210                 215                 220                 


Lys Ile Ser Ile Ser Glu Glu Glu Tyr Thr Ile Arg Glu Asp Glu Leu 
225                 230                 235                 240 


Tyr Lys Ser Ala Leu Ile Tyr Glu Lys Ala Met Asn Phe Val Glu Lys 
                245                 250                 255     


Val Tyr Ser Ile Leu Lys Glu Lys Val Lys Asp Phe Asp Leu Glu Ile 
            260                 265                 270         


Ser Ile Asp Glu Gly Glu Lys Asp Thr Thr Val Glu Asp His Ile Phe 
        275                 280                 285             


Val Ala Glu Tyr Leu His Lys Lys Gly Ile Asp Phe Trp Ser Leu Ala 
    290                 295                 300                 


Pro Lys Phe Pro Gly Glu Phe Gln Lys Ala Ile Asp Tyr Lys Gly Asp 
305                 310                 315                 320 


Ile Asn Lys Phe Ala Val Glu Leu Lys Lys His Tyr Ala Ile Ser Gln 
                325                 330                 335     


Gln Leu Gly Gly Tyr Lys Leu Ser Leu His Ser Gly Ser Asp Lys Phe 
            340                 345                 350         


Ser Ile Tyr Glu Ile Phe Ser Glu Val Thr Gln His Ser Phe His Ile 
        355                 360                 365             


Lys Thr Ser Gly Thr Ser Trp Leu Gln Ala Val Asn Leu Ile Phe Glu 
    370                 375                 380                 


Lys Asn Lys Lys Leu Phe Tyr Glu Leu Tyr Lys Ile Ala Leu Asn Asn 
385                 390                 395                 400 


Leu Glu Glu Ser Lys Lys Ala Tyr Lys Val Leu Ile Asp Lys Asp Asp 
                405                 410                 415     


Phe Ala Glu Glu Pro Asn Leu Glu Asn Val Gln Ile Leu Ser Gln Pro 
            420                 425                 430         


Glu Ile Lys Gln Leu Phe His Ile Ser Tyr Gly Val Leu Leu Asp Glu 
        435                 440                 445             


Lys Lys Glu Glu Ile Tyr Asp Val Leu Asp Lys Tyr Glu Glu Glu His 
    450                 455                 460                 


Tyr Gln Phe Val Ser Ala Asn Ile Lys Asn His Leu Gly Lys Ile Phe 
465                 470                 475                 480 


Asn Asn 
        


<210>  341
<211>  482
<212>  PRT
<213>  Thermoanaerobacter italicus

<400>  341

Met Val Glu Lys Gly Ile Leu Glu Lys Leu Thr Asp Phe Leu Leu Asn 
1               5                   10                  15      


His Ser Phe Val Leu Tyr Pro Asn Ser Leu Arg Lys Leu Lys Glu Asp 
            20                  25                  30          


Thr Tyr Ile Phe Val Ala Lys Lys Asp Ala Asp Lys Lys Ile Gly Ile 
        35                  40                  45              


Leu Thr Lys Glu Asn Phe Lys Leu Ser Ser Pro Tyr Phe Val Glu Asp 
    50                  55                  60                  


Lys Asn Val Lys Glu Ile Asp Phe Tyr Leu Asn Leu Tyr Pro Leu Ser 
65                  70                  75                  80  


Phe Glu Asn Tyr Leu Ile Leu Lys Asn Phe Gly Ile Ser Pro Thr Pro 
                85                  90                  95      


Cys Arg Gln Lys Ser Ser Phe Gly Thr Gly Asp Arg Leu Gly Leu Val 
            100                 105                 110         


Thr Pro Ala His Ile Val Ala Leu Lys Glu Tyr Pro Val Phe Pro Val 
        115                 120                 125             


Leu Val Gln Gln Ser Pro Arg Glu Leu Glu Lys Thr Arg Arg Asp Phe 
    130                 135                 140                 


Lys Asp Ala Leu Leu Lys Val Ile Leu Gly Val Leu Glu Ala Gly Tyr 
145                 150                 155                 160 


Thr Gly Glu Phe Gly Ala Asp Ala Asp His Ile Lys Asp Glu Lys Tyr 
                165                 170                 175     


Leu Leu Arg Ala Ile Glu Ala Gly Tyr Thr Met Tyr Thr Leu Asp Val 
            180                 185                 190         


Ser Glu Leu Leu Thr Lys Ile Ser Asp Ile Ser Ser Asn Gln Val Met 
        195                 200                 205             


Gln Ile Ser Pro Gln Ser Lys Glu Ile Ile Glu Ala Phe Lys Gly Lys 
    210                 215                 220                 


Lys Ile Ser Ile Ser Glu Glu Glu Tyr Thr Ile Arg Glu Asp Glu Leu 
225                 230                 235                 240 


Tyr Lys Ser Ala Leu Ile Tyr Glu Lys Ala Met Asn Phe Val Glu Lys 
                245                 250                 255     


Val Tyr Ser Ile Leu Lys Glu Lys Val Lys Asp Phe Asp Leu Glu Ile 
            260                 265                 270         


Ser Ile Asp Glu Gly Glu Lys Asp Thr Thr Val Glu Asp His Ile Phe 
        275                 280                 285             


Val Ala Glu Tyr Leu His Lys Lys Gly Ile Asp Phe Trp Ser Leu Ala 
    290                 295                 300                 


Pro Lys Phe Pro Gly Glu Phe Gln Lys Ala Ile Asp Tyr Lys Gly Asp 
305                 310                 315                 320 


Ile Asn Lys Phe Ala Val Glu Leu Lys Lys His Tyr Ala Ile Ser Gln 
                325                 330                 335     


Gln Phe Gly Gly Tyr Lys Leu Ser Leu His Ser Gly Ser Asp Lys Phe 
            340                 345                 350         


Ser Ile Tyr Glu Ile Phe Ser Glu Val Thr Gln His Ser Phe His Ile 
        355                 360                 365             


Lys Thr Ser Gly Thr Ser Trp Leu Gln Ala Val Asn Leu Ile Phe Glu 
    370                 375                 380                 


Lys Asp Lys Lys Leu Phe Tyr Glu Leu Tyr Lys Ile Ala Leu Asn Asn 
385                 390                 395                 400 


Leu Glu Glu Ser Lys Lys Ala Tyr Lys Val Leu Ile Asp Lys Asp Asp 
                405                 410                 415     


Phe Ala Glu Glu Pro Asn Leu Glu Asn Ala Gln Ile Leu Ser Gln Pro 
            420                 425                 430         


Glu Ile Lys Gln Leu Phe His Ile Ser Tyr Gly Val Leu Leu Asp Glu 
        435                 440                 445             


Lys Lys Glu Glu Ile Tyr Asp Val Leu Asp Lys Tyr Glu Glu Glu His 
    450                 455                 460                 


Tyr Gln Phe Val Ser Ala Asn Ile Lys Asn His Leu Glu Lys Ile Phe 
465                 470                 475                 480 


Asn Lys 
        


<210>  342
<211>  483
<212>  PRT
<213>  Thermoanaerobacterium thermosaccharolyticum

<400>  342

Met Ile Gly Asn Val Leu Ser Thr Leu Glu Glu Asn Gly Phe Lys Val 
1               5                   10                  15      


Tyr Pro Asp Ser Leu Arg Lys Leu Gly Glu Asn Ile Tyr Ile Phe Val 
            20                  25                  30          


Val Lys Arg Gln Asn Glu Lys Met Val Gly Ile Leu Ser Ser Ser Asp 
        35                  40                  45              


Val Lys Leu Asn Gly Ala Tyr Phe Ser Glu Asp Lys Asn Val Ser Asp 
    50                  55                  60                  


Lys Leu Arg Leu Asn Ile Tyr Pro Phe Thr Phe Glu Asn Tyr Val Thr 
65                  70                  75                  80  


Leu Asn Gly Lys Phe His Ile Gly Pro Thr Val Cys Arg Gly Asn Ser 
                85                  90                  95      


Ser Phe Gly Thr Gly Asp Arg Leu Gly Leu Val Thr Ala Ala Gln Leu 
            100                 105                 110         


Thr Ala Leu Lys Lys Tyr Asp Val Phe Pro Ile Leu Ala Gln Gln Ser 
        115                 120                 125             


Pro Arg Glu Leu Ile Lys Thr Asn Arg Asp Phe Lys Asp Val Leu Leu 
    130                 135                 140                 


Lys Val Val Leu Gly Val Leu Glu Thr Gly Tyr Ile Gly His Phe Gly 
145                 150                 155                 160 


Ala Asp Ala Asp His Ile Lys Asp Glu Tyr Tyr Leu Leu Glu Gly Ile 
                165                 170                 175     


Asn Ala Gly Tyr Thr Met Tyr Thr Leu Asp Leu Ser Glu Gln Leu Ile 
            180                 185                 190         


Asp Ile Ser Ser Leu Asn Pro Ser Glu Met Arg Asn Lys Ala Gln Glu 
        195                 200                 205             


Leu Ser Gln Val Ser Lys Asp Ile Ile Lys Asp Phe Ser Gly Lys Lys 
    210                 215                 220                 


Leu Asp Ile Ile Ser Asp Ser Gly Tyr Val Val Ser Glu Glu Glu Leu 
225                 230                 235                 240 


Tyr Lys Ser Ala Val Ala Tyr Glu Asn Ser Met Lys Phe Val Asp Lys 
                245                 250                 255     


Val Asn Asn Ile Leu Lys Glu Lys Leu Ser Asp Phe Asp Met Glu Ile 
            260                 265                 270         


Ser Ile Asp Glu Gly Gly Lys Val Thr Thr Leu Glu Asp His Leu Tyr 
        275                 280                 285             


Val Ala Glu Tyr Leu His Arg Ser Gly Ile Asp Phe Phe Ser Ile Ala 
    290                 295                 300                 


Pro Lys Phe Pro Gly Glu Phe Glu Lys Ala Val Asp Tyr Ile Gly Asp 
305                 310                 315                 320 


Leu Asp Glu Phe Ser Leu Glu Leu Lys Lys His Tyr Gln Leu Ser Arg 
                325                 330                 335     


Met Ile Gly Gly Tyr Lys Ile Ser Leu His Ser Gly Ser Asp Lys Phe 
            340                 345                 350         


Ser Ile Tyr Arg Ile Phe Ser Asp Ile Thr Glu Lys Asn Phe His Ile 
        355                 360                 365             


Lys Thr Ser Gly Thr Ser Trp Leu Gln Ala Ile Asn Leu Ile Tyr Asn 
    370                 375                 380                 


Tyr Asp Lys Glu Phe Tyr Arg Glu Leu Tyr Lys Ile Ala Leu Glu Asn 
385                 390                 395                 400 


Leu Glu Glu Ser Lys Lys Ser Tyr Lys Val Leu Ile Lys Arg Glu Asp 
                405                 410                 415     


Phe Cys Lys Glu Pro Glu Leu Asn Asn Pro Asn Phe Ile Leu Lys Pro 
            420                 425                 430         


Glu Ile Lys Gln Leu Phe His Ile Ser Phe Gly Val Leu Leu Asp Leu 
        435                 440                 445             


Lys Arg Lys Glu Met Val Asp Phe Leu Asn Lys Tyr Glu Glu Glu His 
    450                 455                 460                 


Tyr Lys Met Val Ser Lys Asn Ile Asp Asn His Leu Lys Glu Ile Phe 
465                 470                 475                 480 


Tyr Lys Asn 
            


<210>  343
<211>  483
<212>  PRT
<213>  Thermoanaerobacterium thermosaccharolyticum

<400>  343

Met Ile Gly Asn Val Leu Ser Thr Leu Glu Glu Asn Gly Phe Lys Val 
1               5                   10                  15      


Tyr Pro Asp Ser Leu Arg Lys Leu Gly Glu Asn Ile Tyr Ile Phe Val 
            20                  25                  30          


Val Lys Arg Gln Asn Glu Lys Met Val Gly Ile Leu Ser Ser Ser Asp 
        35                  40                  45              


Val Lys Leu Asn Gly Ala Tyr Phe Ser Glu Asp Lys Asn Val Ser Asp 
    50                  55                  60                  


Lys Leu Arg Leu Asn Ile Tyr Pro Phe Thr Phe Glu Asn Tyr Val Thr 
65                  70                  75                  80  


Leu Asn Gly Lys Phe His Ile Gly Pro Thr Val Cys Arg Gly Asn Ser 
                85                  90                  95      


Ser Phe Gly Thr Gly Asp Arg Leu Gly Leu Val Thr Ala Ala Gln Leu 
            100                 105                 110         


Thr Ala Leu Lys Lys Tyr Asp Val Phe Pro Ile Leu Ala Gln Gln Ser 
        115                 120                 125             


Pro Arg Glu Leu Ile Lys Thr Asn Arg Asp Phe Lys Asp Val Leu Leu 
    130                 135                 140                 


Lys Val Val Leu Gly Val Leu Glu Thr Gly Tyr Ile Gly His Phe Gly 
145                 150                 155                 160 


Ala Asp Ala Asp His Ile Lys Asp Glu Tyr Tyr Leu Leu Glu Gly Ile 
                165                 170                 175     


Asn Ala Gly Tyr Thr Met Tyr Thr Leu Asp Leu Ser Glu Gln Leu Ile 
            180                 185                 190         


Asp Ile Ser Ser Leu Asn Ala Ser Glu Met Arg Asn Lys Ala Gln Glu 
        195                 200                 205             


Leu Ser Gln Val Ser Lys Asp Ile Ile Lys Asp Phe Ser Gly Lys Lys 
    210                 215                 220                 


Leu Asp Ile Ile Ser Asp Ser Gly Tyr Val Val Ser Glu Glu Glu Leu 
225                 230                 235                 240 


Tyr Lys Ser Ala Val Ala Tyr Glu Asn Ala Met Lys Phe Val Asp Lys 
                245                 250                 255     


Val Asn Asn Ile Leu Lys Glu Lys Leu Ser Asp Phe Asp Met Glu Ile 
            260                 265                 270         


Ser Ile Asp Glu Gly Gly Lys Val Thr Thr Leu Glu Asp His Leu Tyr 
        275                 280                 285             


Val Ala Glu Tyr Leu His Arg Asn Gly Ile Asp Phe Phe Ser Ile Ala 
    290                 295                 300                 


Pro Lys Phe Pro Gly Glu Phe Glu Lys Ala Val Asp Tyr Ile Gly Asp 
305                 310                 315                 320 


Leu Asp Glu Phe Leu Leu Glu Leu Lys Lys His Tyr Gln Leu Ser Arg 
                325                 330                 335     


Met Ile Gly Gly Tyr Lys Ile Ser Leu His Ser Gly Ser Asp Lys Phe 
            340                 345                 350         


Ser Ile Tyr Arg Ile Phe Ser Asp Ile Thr Glu Lys Asn Phe His Ile 
        355                 360                 365             


Lys Thr Ser Gly Thr Ser Trp Leu Gln Ala Ile Asn Leu Ile Tyr Asn 
    370                 375                 380                 


Tyr Asp Lys Glu Phe Tyr Arg Glu Leu Tyr Lys Ile Ala Leu Glu Asn 
385                 390                 395                 400 


Leu Glu Glu Ser Lys Lys Ser Tyr Lys Val Leu Ile Lys Arg Glu Asp 
                405                 410                 415     


Phe Cys Lys Glu Pro Glu Leu Asn Asn Pro Lys Phe Ile Leu Lys Pro 
            420                 425                 430         


Glu Ile Lys Gln Leu Phe His Ile Ser Phe Gly Val Leu Leu Asn Leu 
        435                 440                 445             


Lys Arg Lys Glu Ile Val Asp Phe Leu Asn Lys Tyr Glu Glu Glu His 
    450                 455                 460                 


Tyr Lys Met Val Ser Lys Asn Ile Asp Asn His Leu Lys Glu Ile Phe 
465                 470                 475                 480 


Tyr Lys Asn 
            


<210>  344
<211>  483
<212>  PRT
<213>  Thermoanaerobacterium thermosaccharolyticum

<400>  344

Met Ile Gly Asn Val Leu Ser Thr Leu Glu Glu Asn Gly Phe Lys Val 
1               5                   10                  15      


Tyr Pro Asp Ser Leu Met Lys Leu Gly Glu Asn Ile Tyr Ile Phe Val 
            20                  25                  30          


Val Lys Arg Gln Asn Glu Lys Met Val Gly Ile Leu Ser Ser Ser Asp 
        35                  40                  45              


Val Lys Leu Asn Gly Ala Tyr Phe Ser Glu Asp Lys Asn Val Ser Asp 
    50                  55                  60                  


Lys Leu Arg Leu Asn Ile Tyr Pro Phe Thr Phe Glu Asn Tyr Val Thr 
65                  70                  75                  80  


Leu Asn Gly Lys Phe His Ile Gly Pro Thr Val Cys Arg Gly Asn Ser 
                85                  90                  95      


Ser Phe Gly Thr Gly Asp Arg Leu Gly Leu Val Thr Ala Ala Gln Leu 
            100                 105                 110         


Thr Ala Leu Lys Lys Tyr Asp Val Phe Pro Ile Leu Ala Gln Gln Ser 
        115                 120                 125             


Pro Arg Glu Leu Ile Lys Thr Asn Arg Asp Phe Lys Asp Val Leu Leu 
    130                 135                 140                 


Lys Val Val Leu Gly Val Leu Glu Thr Gly Tyr Ile Gly His Phe Gly 
145                 150                 155                 160 


Ala Asp Ala Asp His Ile Lys Asp Glu Tyr Tyr Leu Leu Glu Gly Ile 
                165                 170                 175     


Asn Ala Gly Tyr Thr Met Tyr Thr Leu Asp Leu Ser Glu Gln Leu Ile 
            180                 185                 190         


Asp Ile Ser Ser Leu Asn Pro Ser Glu Met Arg Asn Lys Ala Gln Glu 
        195                 200                 205             


Leu Ser Gln Val Ser Lys Asp Ile Ile Lys Asp Phe Ser Gly Lys Lys 
    210                 215                 220                 


Leu Asp Ile Ile Ser Asp Ser Gly Tyr Val Val Ser Glu Glu Glu Leu 
225                 230                 235                 240 


Tyr Lys Ser Ala Val Ala Tyr Glu Asn Ala Met Lys Phe Val Asp Lys 
                245                 250                 255     


Val Asn Asn Ile Leu Lys Glu Lys Leu Ser Asp Phe Asp Met Glu Ile 
            260                 265                 270         


Ser Ile Asp Glu Gly Gly Lys Val Thr Thr Leu Glu Asp His Leu Tyr 
        275                 280                 285             


Val Ala Glu Tyr Leu His Arg Asn Gly Ile Asp Phe Phe Ser Ile Ala 
    290                 295                 300                 


Pro Lys Phe Pro Gly Glu Phe Glu Lys Ala Val Asp Tyr Ile Gly Asp 
305                 310                 315                 320 


Leu Asp Glu Phe Leu Leu Glu Leu Lys Lys His Tyr Gln Leu Ser Arg 
                325                 330                 335     


Met Ile Gly Gly Tyr Lys Ile Ser Leu His Ser Gly Ser Asp Lys Phe 
            340                 345                 350         


Ser Ile Tyr Arg Ile Phe Ser Asp Ile Thr Glu Lys Asn Phe His Ile 
        355                 360                 365             


Lys Thr Ser Gly Thr Ser Trp Leu Gln Ala Ile Asn Leu Ile Tyr Asp 
    370                 375                 380                 


Tyr Asp Lys Glu Phe Tyr Arg Glu Leu Tyr Lys Ile Ala Leu Glu Asn 
385                 390                 395                 400 


Leu Glu Glu Ser Lys Lys Ser Tyr Lys Val Leu Ile Lys Lys Glu Asp 
                405                 410                 415     


Phe Gly Lys Glu Pro Glu Leu Asn Asn Pro Lys Phe Ile Leu Lys Pro 
            420                 425                 430         


Glu Ile Lys Gln Leu Phe His Ile Ser Phe Gly Val Leu Leu Asp Leu 
        435                 440                 445             


Lys Arg Lys Glu Ile Val Asp Phe Leu Asn Lys Tyr Glu Glu Glu His 
    450                 455                 460                 


Tyr Lys Met Val Ser Lys Asn Ile Asp Asn His Leu Lys Glu Ile Phe 
465                 470                 475                 480 


Tyr Lys Asn 
            


<210>  345
<211>  483
<212>  PRT
<213>  Thermoanaerobacterium thermosaccharolyticum

<400>  345

Met Ile Gly Asn Val Leu Ser Thr Leu Glu Glu Asn Gly Phe Lys Val 
1               5                   10                  15      


Tyr Pro Asp Ser Leu Arg Lys Leu Gly Glu Asn Ile Tyr Ile Phe Val 
            20                  25                  30          


Val Lys Arg Gln Asn Glu Lys Met Val Gly Ile Leu Ser Ser Ser Asp 
        35                  40                  45              


Val Lys Leu Asn Gly Ala Tyr Phe Ser Glu Asp Lys Asn Val Ser Asp 
    50                  55                  60                  


Lys Leu Arg Leu Asn Ile Tyr Pro Phe Thr Phe Glu Asn Tyr Val Thr 
65                  70                  75                  80  


Leu Asn Gly Lys Phe His Ile Gly Pro Thr Val Cys Arg Gly Asn Ser 
                85                  90                  95      


Ser Phe Gly Thr Gly Asp Arg Leu Gly Leu Val Thr Ala Ala Gln Leu 
            100                 105                 110         


Thr Ala Leu Lys Lys Tyr Asp Val Phe Pro Ile Leu Ala Gln Gln Ser 
        115                 120                 125             


Pro Arg Glu Leu Ile Lys Thr Asn Arg Asp Phe Lys Asp Val Leu Leu 
    130                 135                 140                 


Lys Val Val Leu Gly Val Leu Glu Thr Gly Tyr Ile Gly His Phe Gly 
145                 150                 155                 160 


Ala Asp Ala Asp His Ile Lys Asp Glu Tyr Asn Leu Leu Glu Gly Ile 
                165                 170                 175     


Asn Ala Gly Tyr Thr Met Tyr Thr Leu Asp Leu Ser Glu Gln Leu Ile 
            180                 185                 190         


Asp Ile Ser Ser Leu Asn Ala Ser Glu Met Arg Asn Lys Ala Gln Glu 
        195                 200                 205             


Leu Ser Gln Val Ser Lys Asp Ile Ile Lys Asp Phe Ser Gly Lys Lys 
    210                 215                 220                 


Leu Asp Ile Ile Ser Asp Ser Gly Tyr Val Val Ser Glu Glu Glu Leu 
225                 230                 235                 240 


Tyr Lys Ser Ala Val Ala Tyr Glu Asn Ala Met Lys Phe Val Asp Lys 
                245                 250                 255     


Val Asn Asn Ile Leu Lys Glu Lys Leu Ser Asp Phe Asp Met Glu Ile 
            260                 265                 270         


Ser Ile Asp Glu Gly Gly Lys Val Thr Thr Leu Glu Asp His Leu Tyr 
        275                 280                 285             


Val Ala Glu Tyr Leu His Arg Asn Gly Ile Asp Phe Phe Ser Ile Ala 
    290                 295                 300                 


Pro Lys Phe Pro Gly Glu Phe Glu Lys Ala Val Asp Tyr Ile Gly Asp 
305                 310                 315                 320 


Leu Asp Glu Phe Leu Leu Glu Leu Lys Lys His Tyr Gln Leu Ser Arg 
                325                 330                 335     


Met Ile Gly Gly Tyr Lys Ile Ser Leu His Ser Gly Ser Asp Lys Phe 
            340                 345                 350         


Ser Ile Tyr Arg Ile Phe Ser Asp Ile Thr Glu Lys Asn Phe His Ile 
        355                 360                 365             


Lys Thr Ser Gly Thr Ser Trp Leu Gln Ala Val Asn Leu Ile Tyr Lys 
    370                 375                 380                 


Phe Asp Lys Glu Phe Tyr Arg Lys Leu Tyr Lys Ile Ala Leu Ser Asn 
385                 390                 395                 400 


Leu Glu Glu Ser Lys Lys Ser Tyr Lys Val Leu Ile Lys Lys Asp Asp 
                405                 410                 415     


Phe Lys Asp Glu Pro Glu Leu Asp Asn Pro Glu Phe Thr Leu Arg Pro 
            420                 425                 430         


Glu Ile Lys Gln Leu Phe His Ile Ser Phe Gly Val Leu Leu Asp Leu 
        435                 440                 445             


Lys Gly Lys Glu Ile Lys Asp Met Leu Asn Asp Tyr Glu Glu Glu His 
    450                 455                 460                 


Tyr Lys Met Val Ser Asp Asn Ile Glu Asn His Leu Lys Glu Ile Tyr 
465                 470                 475                 480 


Tyr Glu Lys 
            


<210>  346
<211>  482
<212>  PRT
<213>  Thermoanaerobacterium xylanolyticum

<400>  346

Met Val Gly Asn Val Ser Ser Val Leu Lys Glu Ser Gly Phe Gln Ile 
1               5                   10                  15      


Tyr Pro Asp Ser Leu Arg Lys Leu Gly Glu Asn Thr Tyr Ile Phe Val 
            20                  25                  30          


Val Lys Lys Gln Lys Glu Lys Met Ile Gly Ile Leu Ser Asn Asp Glu 
        35                  40                  45              


Leu Lys Leu Lys Glu Pro Tyr Phe Ser Glu Asn Lys Lys Ile Ser Asp 
    50                  55                  60                  


Asn Leu Gln Phe Asn Val Tyr Ser Phe Thr Phe Asp Asn Tyr Val Thr 
65                  70                  75                  80  


Leu Asn Gly Arg Phe His Ile Gly Pro Thr Ile Cys Arg Glu Asn Ala 
                85                  90                  95      


Ser Phe Gly Thr Gly Asp Arg Leu Gly Leu Ala Thr Ala Ala Gln Leu 
            100                 105                 110         


Asp Ala Leu Lys Lys Phe Asn Val Phe Pro Ile Leu Ala Gln Gln Ser 
        115                 120                 125             


Pro Arg Glu Leu Val Lys Thr Asn Arg Asp Phe Lys Asp Val Leu Leu 
    130                 135                 140                 


Lys Val Val Leu Gly Val Leu Glu Thr Gly Tyr Ile Gly His Tyr Gly 
145                 150                 155                 160 


Ala Asp Ala Asp His Ile Lys Asp Glu Lys Tyr Leu Leu Glu Gly Ile 
                165                 170                 175     


Asp Ala Gly Tyr Thr Met Tyr Thr Leu Asp Leu Ser Glu Gln Leu Phe 
            180                 185                 190         


Asp Val Ser Gly Ala Thr Ser Leu Glu Ile Lys Glu Lys Ala Lys Thr 
        195                 200                 205             


Leu Ser Asp Val Ser Arg Lys Ile Val Glu Asp Phe Ser Gly Lys Ser 
    210                 215                 220                 


Leu Asn Val Gly Phe Gly Gly His Leu Val Ser Glu Asp Glu Leu Leu 
225                 230                 235                 240 


Lys Ser Ala Val Ala Tyr Glu Ala Ala Met Lys Phe Val Glu Lys Val 
                245                 250                 255     


Asn Asp Ile Leu Lys Glu Lys Leu Asn Asp Phe Asp Leu Glu Ile Ser 
            260                 265                 270         


Ile Asp Glu Gly Gly Lys Val Thr Thr Leu Glu Asp His Leu Phe Val 
        275                 280                 285             


Ala Glu Tyr Leu His Arg Asn Gly Ile Asp Phe Phe Ser Ile Ala Pro 
    290                 295                 300                 


Lys Phe Pro Gly Glu Phe Glu Lys Ala Ile Asp Tyr Val Gly Asp Val 
305                 310                 315                 320 


Asn Glu Phe Glu Arg Glu Leu Lys Lys His Tyr Asp Leu Thr Lys Leu 
                325                 330                 335     


Ile Gly Gly Tyr Lys Leu Ser Leu His Ser Gly Ser Asp Lys Phe Ser 
            340                 345                 350         


Ile Tyr Lys Ile Phe Ser Gln Thr Thr Glu Lys Asn Phe His Ile Lys 
        355                 360                 365             


Thr Ser Gly Thr Ser Trp Leu Gln Ala Val Asn Leu Ile Tyr Lys Ser 
    370                 375                 380                 


Asp Lys Glu Phe Tyr Arg Glu Leu Tyr Lys Ile Ala Leu Ser Asn Leu 
385                 390                 395                 400 


Glu Glu Ser Lys Lys Ser Tyr Lys Val Leu Ile Lys Lys Asp Asp Phe 
                405                 410                 415     


Lys Asp Glu Pro Glu Leu Asp Asn Ser Glu Phe Ile Ile Arg Pro Glu 
            420                 425                 430         


Ile Lys Gln Leu Phe His Ile Ser Phe Gly Val Leu Leu Asp Leu Lys 
        435                 440                 445             


Gly Lys Glu Ile Lys Asp Met Leu Tyr Asp Tyr Glu Glu Glu His Tyr 
    450                 455                 460                 


Lys Met Val Ser Asp Asn Ile Glu Asn His Leu Lys Glu Ile Phe Tyr 
465                 470                 475                 480 


Glu Lys 
        


<210>  347
<211>  386
<212>  PRT
<213>  Petrotoga mobilis

<400>  347

Met Leu Thr Ile Leu Pro Asn Lys Gly Ile Ser Leu Gly Leu Gly Asp 
1               5                   10                  15      


Arg Ile Gly Ile Ala Thr His Gly His Ile Lys Val Ala Lys Lys Tyr 
            20                  25                  30          


Asn Phe Phe Pro Val Phe Ala Gln Gln Ser Ile Arg Glu Leu Asn Phe 
        35                  40                  45              


Thr Gly Arg Thr Phe Ser Asp Val Arg Lys Asp Val Leu Asn Ala Leu 
    50                  55                  60                  


Ile Glu Glu Asn Tyr Val Gly Asn Ser Gly Phe Asp Gly Asp His Leu 
65                  70                  75                  80  


Lys Ser Asp Glu Glu Ile Gln Tyr Ala Leu Asp Ser Gly Ile Thr Met 
                85                  90                  95      


Leu Thr Leu Asp Cys Ser Glu His Met Asn Asn Lys Asp Ser Ser Ile 
            100                 105                 110         


Lys Glu Arg Ile Phe Asp Gln Phe Tyr Asn Lys Ser Phe Phe Val Asn 
        115                 120                 125             


Asp Met Pro Ile Glu Tyr Ser Asn Lys Asn Glu Leu Asn Lys Ile Val 
    130                 135                 140                 


Ser Ile Tyr Ala Gly Val Ile Glu Arg Val Ile Asp Val Trp Asn Lys 
145                 150                 155                 160 


Phe Pro Lys Val Asn Lys Lys Glu Val Thr Phe Glu Val Ser Val Asp 
                165                 170                 175     


Glu Thr Asp Val Pro Thr Asp Glu Lys Thr His Phe Leu Ile Ser Lys 
            180                 185                 190         


Tyr Ile Tyr Asp Glu Gly Val Lys Ile Asp Thr Leu Ala Pro Arg Phe 
        195                 200                 205             


Pro Gly Glu Phe Gln Lys Ala Ile Asp Tyr Ile Gly Asn Leu Gln Glu 
    210                 215                 220                 


Phe Lys Lys Ser Leu Ile Lys Gln Asp Lys Ile Ala Lys Tyr Phe Gly 
225                 230                 235                 240 


Tyr Arg Leu Ser Ile His Ser Gly Ser Asp Lys Phe Ser Ile Tyr Pro 
                245                 250                 255     


Ile Ile Gly Glu Val Thr Gln Gly Asn Tyr His Leu Lys Thr Ser Gly 
            260                 265                 270         


Thr Ser Tyr Leu Glu Ala Ile Lys Ile Val Ala Gln Lys Asp Pro Glu 
        275                 280                 285             


Phe Phe Lys Lys Ile Trp Lys Thr Cys Leu Asp Lys Arg Glu Glu Met 
    290                 295                 300                 


Asp Lys Tyr Tyr His Leu Ser Cys Asp Pro Phe Ser Val Pro Lys Asn 
305                 310                 315                 320 


Leu Ser Pro Thr Glu Tyr Leu Gln Asn Pro Asp Ala Arg Gln Thr Leu 
                325                 330                 335     


His Val Ser Tyr Met Phe Val Leu Asn Pro Gln Tyr Asp Phe Arg Glu 
            340                 345                 350         


Lys Phe Phe Glu Ile Leu Thr Lys Tyr Gln Asn Glu Tyr His Gln Asn 
        355                 360                 365             


Val Ala Asn His Ile Glu Lys His Val Lys Glu Leu Lys Val Glu Glu 
    370                 375                 380                 


Lys Ser 
385     


<210>  348
<211>  482
<212>  PRT
<213>  Thermoanaerobacterium saccharolyticum

<400>  348

Met Val Gly Asn Val Ser Ala Val Leu Lys Glu Asn Gly Phe Lys Ile 
1               5                   10                  15      


Tyr Pro Asp Ser Leu Arg Lys Leu Gly Glu Ser Thr Tyr Ile Phe Val 
            20                  25                  30          


Val Lys Lys Gln Lys Glu Lys Met Ile Gly Ile Leu Ser Asn Asp Glu 
        35                  40                  45              


Leu Asn Leu Lys Glu Pro Tyr Phe Ser Glu Asn Lys Lys Ile Ser Asp 
    50                  55                  60                  


Asn Leu Gln Phe Asn Val Tyr Pro Phe Thr Phe Asp Asn Tyr Val Thr 
65                  70                  75                  80  


Leu Asn Gly Arg Phe His Ile Gly Pro Thr Val Cys Arg Glu Asn Ala 
                85                  90                  95      


Ser Phe Gly Thr Gly Asp Arg Leu Gly Met Ala Thr Ala Ala Gln Leu 
            100                 105                 110         


Gly Ala Leu Lys Lys Phe Asp Val Phe Pro Val Leu Ala Gln Gln Ser 
        115                 120                 125             


Pro Arg Glu Leu Val Lys Thr Asn Arg Asp Phe Lys Asp Val Leu Leu 
    130                 135                 140                 


Lys Val Val Leu Gly Val Leu Glu Thr Gly Tyr Ile Gly His Tyr Gly 
145                 150                 155                 160 


Ala Asp Ala Asp His Ile Lys Asp Glu Lys Tyr Leu Leu Glu Gly Ile 
                165                 170                 175     


Asp Ala Gly Tyr Thr Met Tyr Thr Leu Asp Leu Ser Glu Gln Leu Phe 
            180                 185                 190         


Asp Ile Ser Gly Ala Thr Pro Ser Ala Ile Lys Glu Lys Ala Glu Ala 
        195                 200                 205             


Leu Ser Asp Val Ser Lys Lys Ile Val Glu Asp Phe Ser Gly Gln Ser 
    210                 215                 220                 


Leu Asn Val Gly Leu Glu Gly His Leu Val Ser Glu Asp Glu Leu Leu 
225                 230                 235                 240 


Lys Ser Ala Ile Ala Tyr Glu Gly Ala Met Lys Phe Val Glu Lys Val 
                245                 250                 255     


Asn Asp Ile Leu Lys Glu Lys Leu Asn Asp Phe Asp Leu Glu Ile Ser 
            260                 265                 270         


Ile Asp Glu Gly Gly Lys Val Thr Thr Leu Glu Asp His Leu Phe Val 
        275                 280                 285             


Ala Glu Tyr Leu His Arg Asn Gly Ile Asp Phe Phe Ser Ile Ala Pro 
    290                 295                 300                 


Lys Phe Pro Gly Glu Phe Glu Lys Ala Ile Asp Tyr Val Gly Asp Val 
305                 310                 315                 320 


Asp Glu Phe Lys Lys Ala Leu Lys Lys His Tyr Asp Leu Thr Lys Leu 
                325                 330                 335     


Ile Gly Gly Tyr Lys Leu Ser Leu His Ser Gly Ser Asp Lys Phe Ser 
            340                 345                 350         


Ile Tyr Lys Ile Phe Ser Gln Thr Thr Glu Arg Asn Phe His Ile Lys 
        355                 360                 365             


Thr Ser Gly Thr Ser Trp Leu Gln Ala Val Asn Leu Ile Tyr Lys Ser 
    370                 375                 380                 


Asp Arg Glu Phe Tyr Arg Glu Leu Tyr Lys Ile Ala Leu Ser Asn Leu 
385                 390                 395                 400 


Glu Glu Ser Lys Lys Ser Tyr Lys Val Leu Ile Lys Lys Asp Asp Phe 
                405                 410                 415     


Lys Asp Glu Pro Glu Leu Asp Asn Pro Glu Phe Ile Val Arg Pro Glu 
            420                 425                 430         


Ile Lys Gln Leu Phe His Ile Ser Phe Gly Val Leu Leu Asp Leu Lys 
        435                 440                 445             


Gly Lys Glu Ile Lys Asp Met Leu Tyr Glu His Glu Glu Glu His Tyr 
    450                 455                 460                 


Lys Met Val Ser Asn Asn Ile Glu Asn His Leu Lys Glu Ile Tyr Tyr 
465                 470                 475                 480 


Glu Lys 
        


<210>  349
<211>  390
<212>  PRT
<213>  Petrotoga mobilis

<400>  349

Met Phe Thr Ile Leu Pro Lys Arg Gly Ile Ser Leu Gly Leu Gly Asp 
1               5                   10                  15      


Arg Ile Gly Ile Ala Thr Thr Gly His Ile Lys Val Ala Lys Lys Tyr 
            20                  25                  30          


Asn Phe Phe Pro Val Phe Ala Gln Gln Ser Ile Arg Glu Leu Asn Phe 
        35                  40                  45              


Thr Gly Arg Thr Phe Ile Asp Val Arg Lys Asp Ala Leu Asn Ala Leu 
    50                  55                  60                  


Val Glu Glu Asn Tyr Val Gly Asn Ser Gly Phe Asp Gly Asp His Leu 
65                  70                  75                  80  


Lys Ser Asp Glu Glu Ile Gln Tyr Ala Leu Asp Ser Gly Ile Thr Met 
                85                  90                  95      


Leu Thr Leu Asp Cys Ser Glu His Met Asn Lys Asp Ser Ser Ile Lys 
            100                 105                 110         


Asp Gln Ile Phe Glu Gln Phe Tyr Asn Lys Ser Phe Phe Val Asn Asp 
        115                 120                 125             


Met Pro Ile Glu Tyr Ser Asp Lys Asn Glu Leu Asn Lys Ile Val Ser 
    130                 135                 140                 


Ile Tyr Ala Ser Val Ile Glu Arg Val Ile Asp Val Trp Asn Lys Phe 
145                 150                 155                 160 


Pro Lys Val Asn Lys Lys Glu Val Thr Phe Glu Val Ser Val Asp Glu 
                165                 170                 175     


Thr Asp Val Pro Thr Asp Glu Lys Thr His Phe Leu Ile Ser Lys Tyr 
            180                 185                 190         


Ile Tyr Asp Glu Gly Val Lys Ile Asp Thr Leu Ala Pro Arg Phe Pro 
        195                 200                 205             


Gly Glu Phe Gln Lys Gly Ile Asp Tyr Ile Gly Asn Ile Gln Glu Phe 
    210                 215                 220                 


Lys Lys Ser Leu Ile Lys Gln Asp Lys Ile Ala Lys Tyr Phe Gly Tyr 
225                 230                 235                 240 


Arg Leu Ser Ile His Ser Gly Ser Asp Lys Phe Ser Ile Tyr Pro Ile 
                245                 250                 255     


Ile Gly Glu Val Thr Gln Gly Asn Tyr His Leu Lys Thr Ser Gly Thr 
            260                 265                 270         


Ser Tyr Leu Glu Ala Ile Lys Val Val Ala Gln Lys Asp Pro Glu Phe 
        275                 280                 285             


Phe Lys Lys Ile Trp Gln Thr Cys Leu Asp Lys Arg Glu Glu Met Asp 
    290                 295                 300                 


Lys Tyr Tyr His Leu Ser Cys Asp Pro Phe Ser Val Pro Lys Asp Leu 
305                 310                 315                 320 


Ser Pro Thr Glu Tyr Leu Lys Asn Pro Asp Ala Arg Gln Thr Leu His 
                325                 330                 335     


Val Ser Tyr Met Phe Val Leu Asn Pro Gln Tyr Asp Phe Arg Glu Lys 
            340                 345                 350         


Phe Ile Glu Ile Leu Thr Lys Tyr Gln Asn Glu Tyr His Gln Asn Ala 
        355                 360                 365             


Ala Asn His Ile Glu Lys His Val Lys Glu Leu Lys Val Glu Glu Lys 
    370                 375                 380                 


Ile His Lys Gln Lys Asn 
385                 390 


<210>  350
<211>  426
<212>  PRT
<213>  Spirochaeta thermophila

<400>  350

Met Thr Thr Pro Gly Ser Leu Ser Leu Pro Arg Tyr Ser Ile Gly Thr 
1               5                   10                  15      


Gly Asp Arg Phe Gly His Glu Ala Glu Ala Gln Leu Arg Ala Val Ile 
            20                  25                  30          


Glu Ala Glu Arg Leu Gly Met Ala Leu Gly Ile Val Trp Asn Lys Ser 
        35                  40                  45              


Tyr Arg Glu His Thr Ile Ile Gly Ser Arg Pro Glu Asp Val Arg Arg 
    50                  55                  60                  


Met Ala Asp Lys Ala Val Ser Ala Leu Glu Trp Glu Gly Pro Tyr Phe 
65                  70                  75                  80  


Val Asp Ala Asp His Ile Thr Thr Lys Thr Val Glu Leu Phe Leu Asp 
                85                  90                  95      


Ser Ser Asp Phe Phe Thr Ile Asp Val Ala Glu Ala Ile Gly Gln Glu 
            100                 105                 110         


Glu Ile Ser Pro Gln Glu Glu Glu Asp Leu Leu Ser Ser Leu Asp Asp 
        115                 120                 125             


Leu Leu Asn Arg Glu Leu Ala Ile Pro Gly Leu Ser Asn Pro Leu Thr 
    130                 135                 140                 


Ile Ser Glu Glu Thr Ala Arg Glu Thr Ile Arg Ala Tyr Trp Pro Ala 
145                 150                 155                 160 


Val Arg Glu Ala Ala Arg Ile His Gln Arg Ile Glu Lys Gly Thr Ser 
                165                 170                 175     


Arg Pro Phe Val Val Glu Val Ser Met Asp Glu Thr Ala Asp Pro Gln 
            180                 185                 190         


Arg Pro Pro Glu Leu Leu Leu Ile Leu Ala Met Ile Arg Lys Ala Gly 
        195                 200                 205             


Ile Pro Ala Arg Thr Ile Ala Pro Lys Phe Ser Gly Ser Phe Tyr Lys 
    210                 215                 220                 


Gly Val Asp Tyr Val Gly Asp Pro Glu Val Phe Ala Arg Glu Phe Glu 
225                 230                 235                 240 


Asp Asp Leu Cys Val Val Arg Tyr Ala Arg Glu Ala Phe Arg Leu Pro 
                245                 250                 255     


Glu Gly Leu Lys Leu Ser Val His Ser Gly Ser Asp Lys Phe Ser Leu 
            260                 265                 270         


Tyr Pro Leu Ile Lys Asp Ile Leu Ser Arg His Pro Gln Glu Gly Val 
        275                 280                 285             


His Leu Lys Thr Ala Gly Thr Thr Trp Leu Glu Glu Val Thr Gly Leu 
    290                 295                 300                 


Ala Glu Ser Gly Gly Glu Ala Leu Ala Leu Ala Lys Glu Ile Ala Leu 
305                 310                 315                 320 


Thr Cys Tyr Ser Met Ile Glu Glu Leu Cys Ala Pro Tyr Ala Ala Val 
                325                 330                 335     


Ile Asp Ile Asn Pro Asp Arg Leu Pro Ser Pro Gly Glu Ile Glu Asp 
            340                 345                 350         


Trp Ser Ser Gly Arg Phe Val Glu Ala Leu Glu His Asp Pro Ser Asn 
        355                 360                 365             


Pro Ser Tyr Asn Arg Asp Phe Arg Gln Leu Ile His Val Gly Tyr Lys 
    370                 375                 380                 


Val Ala Ala Gln Met Gly Glu Arg Phe His Glu Ala Leu Glu Ala His 
385                 390                 395                 400 


Arg Glu Val Ile Ala Ala Arg Val Thr Arg Asn Leu Leu Glu Arg His 
                405                 410                 415     


Ile Ile Pro Leu Phe Pro Gly Gly Ala Ala 
            420                 425     


<210>  351
<211>  256
<212>  PRT
<213>  Ignisphaera aggregans

<400>  351

Met Arg Ala Lys Glu Leu Phe Gly Glu Asp Val Ser Ile Glu Ile Ala 
1               5                   10                  15      


Leu Asp Glu Ser Pro Ser Glu Thr Gln Leu Lys Glu Leu Phe Phe Tyr 
            20                  25                  30          


Ile Asn Glu Leu Leu Tyr Lys Gly Leu Arg Phe Glu Phe Ile Ala Pro 
        35                  40                  45              


Asn Ile Gly Phe Arg Lys Arg Glu Asp Tyr Arg Gly Asp Leu Gln Glu 
    50                  55                  60                  


Leu Tyr Asn Arg Val Arg Lys Leu His Thr Ile Ala Ser Asn Asn Gly 
65                  70                  75                  80  


Val Tyr Leu Ser Ile His Ser Gly Ser Gly Ala His Pro Tyr Ser Asp 
                85                  90                  95      


Lys Gly Val Gly Val Trp Ser Thr Ile Gly Arg Ala Thr Asp Gly Leu 
            100                 105                 110         


Val Lys Tyr Lys Met Ser Gly Val Leu Ile Gln Leu Leu Leu Glu Val 
        115                 120                 125             


Met Ser Arg Phe Pro Lys Gly Ser Thr Val Arg Arg Val Tyr Glu Glu 
    130                 135                 140                 


Ile Tyr Asp Ala Val Leu Asp His Leu Lys Lys Asp Ile Ser Arg Gly 
145                 150                 155                 160 


Arg Gly Leu Ala Ser Glu Thr Leu Arg Lys Met Ile Glu Asp Tyr Glu 
                165                 170                 175     


Glu His Ser Asn Lys Tyr Asp Val Arg Ala Asp Val Phe Arg His Tyr 
            180                 185                 190         


Phe Phe Val Phe Gln Cys Ile Arg Asp Asp Ser Gly Val Arg Tyr Leu 
        195                 200                 205             


Arg Asn Arg Val Ile Glu Leu Phe Asn Glu Val Lys Glu Leu Arg Asp 
    210                 215                 220                 


Arg Tyr Arg Glu Glu Val Ala Asn Leu Ile Thr Arg Glu Ala Glu Ala 
225                 230                 235                 240 


Leu Gly Tyr Ile Asn Ser Val Ile Arg Tyr Arg Lys Tyr Glu Tyr Ser 
                245                 250                 255     


<210>  352
<211>  481
<212>  PRT
<213>  Thermotoga maritima

<400>  352

Met Val Leu Lys Val Phe Lys Asp His Phe Gly Arg Gly Tyr Glu Val 
1               5                   10                  15      


Tyr Glu Lys Ser Tyr Arg Glu Lys Asp Ser Leu Ser Phe Phe Leu Thr 
            20                  25                  30          


Lys Glu Glu Glu Gly Lys Ile Leu Val Val Ala Gly Glu Lys Ala Pro 
        35                  40                  45              


Glu Gly Leu Ser Phe Phe Lys Lys Gln Arg Ala Glu Gly Val Ser Phe 
    50                  55                  60                  


Phe Phe Cys Glu Arg Asn His Glu Asn Leu Glu Val Leu Arg Lys Tyr 
65                  70                  75                  80  


Phe Pro Asp Leu Lys Pro Val Arg Ala Gly Leu Arg Ala Ser Phe Gly 
                85                  90                  95      


Thr Gly Asp Arg Leu Gly Ile Thr Thr Pro Ala His Val Arg Ala Leu 
            100                 105                 110         


Lys Asp Ser Gly Leu Phe Pro Ile Phe Ala Gln Gln Ser Val Arg Glu 
        115                 120                 125             


Asn Glu Arg Thr Gly Arg Thr Trp Arg Asp Val Leu Asp Asp Ala Thr 
    130                 135                 140                 


Trp Gly Val Phe Gln Glu Gly Tyr Ser Glu Gly Phe Gly Ala Asp Ala 
145                 150                 155                 160 


Asp His Val Lys Arg Pro Glu Asp Leu Val Ser Ala Ala Arg Glu Gly 
                165                 170                 175     


Phe Thr Met Phe Thr Ile Asp Pro Ser Asp His Val Arg Asn Leu Ser 
            180                 185                 190         


Lys Leu Thr Glu Lys Glu Arg Asn Glu Lys Phe Glu Glu Ile Leu Arg 
        195                 200                 205             


Lys Glu Arg Ile Asp Arg Ile Tyr Leu Gly Lys Lys Tyr Ser Val Leu 
    210                 215                 220                 


Gly Glu Lys Ile Glu Phe Asp Glu Lys Asn Leu Arg Asp Ala Ala Leu 
225                 230                 235                 240 


Val Tyr Tyr Asp Ala Ile Ala His Val Asp Met Met Tyr Gln Ile Leu 
                245                 250                 255     


Lys Asp Glu Thr Pro Asp Phe Asp Phe Glu Val Ser Val Asp Glu Thr 
            260                 265                 270         


Glu Thr Pro Thr Ser Pro Leu Phe His Ile Phe Val Val Glu Glu Leu 
        275                 280                 285             


Arg Arg Arg Gly Val Glu Phe Thr Asn Leu Ala Leu Arg Phe Ile Gly 
    290                 295                 300                 


Glu Trp Glu Lys Gly Ile Asp Tyr Lys Gly Asp Leu Ala Gln Phe Glu 
305                 310                 315                 320 


Arg Glu Ile Lys Met His Ala Glu Ile Ala Arg Met Phe Glu Gly Tyr 
                325                 330                 335     


Lys Ile Ser Leu His Ser Gly Ser Asp Lys Phe Ser Val Tyr Pro Ala 
            340                 345                 350         


Phe Ala Ser Ala Thr Gly Gly Leu Phe His Val Lys Thr Ala Gly Thr 
        355                 360                 365             


Ser Tyr Leu Glu Ala Val Lys Val Ile Ser Met Val Asn Pro Glu Leu 
    370                 375                 380                 


Phe Arg Glu Ile Tyr Arg Cys Thr Leu Asp His Phe Glu Glu Asp Arg 
385                 390                 395                 400 


Lys Ser Tyr His Ile Ser Ala Asp Leu Ser Lys Val Pro Glu Val Glu 
                405                 410                 415     


Lys Val Lys Asp Glu Asp Leu Pro Gly Leu Phe Glu Asp Ile Asn Val 
            420                 425                 430         


Arg Gln Leu Ile His Val Thr Tyr Gly Ser Val Leu Lys Asp Ala Ser 
        435                 440                 445             


Leu Lys Glu Arg Leu Phe Lys Thr Leu Glu Gln Asn Glu Glu Leu Phe 
    450                 455                 460                 


Tyr Glu Thr Val Ala Lys His Ile Lys Arg His Val Asp Leu Leu Glu 
465                 470                 475                 480 


Gly 
    


<210>  353
<211>  483
<212>  PRT
<213>  Caldanaerobacter subterraneus

<400>  353

Met Ile Asn Lys Val Ala Glu Tyr Leu Ser Gly Glu Gly Phe Tyr Phe 
1               5                   10                  15      


Tyr Glu Lys Ser Phe Arg Lys Leu Ser Glu Asp Ile Tyr Ile Phe Val 
            20                  25                  30          


Val Lys Lys Ala Asn Glu Lys Ser Ile Gly Leu Leu Thr Gln Gly Asp 
        35                  40                  45              


Phe Thr Leu Ser Ser Pro His Phe Thr Glu Arg Lys Tyr Leu Lys Glu 
    50                  55                  60                  


Thr Gly Tyr Tyr Leu Asn Leu Tyr Pro Leu Thr Tyr Glu Asn Phe Val 
65                  70                  75                  80  


Ile Leu Lys Asp Lys Phe Asn Ile Ala Pro Ala Pro Cys Asp Lys Lys 
                85                  90                  95      


Ala Ser Phe Gly Met Gly Asp Arg Leu Gly Leu Val Thr Ala Ala His 
            100                 105                 110         


Ile Arg Ala Val Glu Asn Tyr Asp Val Phe Pro Val Leu Ala Gln Gln 
        115                 120                 125             


Ser Pro Arg Glu Leu Met Lys Thr His Arg Ser Phe Lys Glu Ala Ile 
    130                 135                 140                 


Leu Lys Ala Ile Leu Gly Val Leu Glu Glu Gly Tyr Thr Gly Lys Phe 
145                 150                 155                 160 


Gly Ala Asp Ala Asp His Ile Lys Asp Glu Asn Tyr Leu Met Glu Ala 
                165                 170                 175     


Ile Asp Ala Gly Tyr Thr Met Tyr Thr Leu Asp Leu Ser Asp Met Leu 
            180                 185                 190         


Val Lys Leu Ser Asp Tyr Thr Glu Ser Gln Leu Lys Glu Lys Ala Glu 
        195                 200                 205             


Lys Leu Asn Ile Thr Ser Lys Arg Ile Ile Glu Arg Phe Lys Gly Lys 
    210                 215                 220                 


Lys Phe Val Met Pro Thr Lys Glu Ala Phe Thr Val Ser Glu Glu Glu 
225                 230                 235                 240 


Leu Tyr Lys Ser Ala Leu Thr Tyr Glu Lys Ala Met Asp Phe Val Glu 
                245                 250                 255     


Lys Val Tyr Gly Ile Leu Lys Asp Lys Val Lys Asn Phe Asp Leu Glu 
            260                 265                 270         


Ile Ser Ile Asp Glu Gly Asp Lys Asp Thr Thr Val Glu Asp His Ile 
        275                 280                 285             


Phe Val Ala Glu Tyr Leu His Glu Lys Gly Ile Asp Phe Trp Ser Leu 
    290                 295                 300                 


Ala Pro Lys Phe Pro Gly Glu Phe Gln Lys Ala Ile Asp Tyr Ile Gly 
305                 310                 315                 320 


Asp Val Asp Lys Phe Ala Val Glu Leu Lys Lys His Gln Phe Leu Ser 
                325                 330                 335     


Arg Glu Phe Gly Gly Tyr Lys Leu Ser Leu His Ser Gly Ser Asp Lys 
            340                 345                 350         


Phe Ser Ile Tyr Lys Val Phe Ser Glu Ile Thr Glu Gly Glu Phe His 
        355                 360                 365             


Ile Lys Thr Ser Gly Thr Ser Trp Phe Gln Ala Val Asn Leu Ile Phe 
    370                 375                 380                 


Glu Lys Asp Lys Glu Leu Phe Lys Glu Leu Tyr Gln Ile Ala Leu Tyr 
385                 390                 395                 400 


Asn Leu Glu Glu Ser Lys Lys Ala Tyr Lys Val Leu Ile Asp Lys Lys 
                405                 410                 415     


Asp Phe Pro Glu Asn Ile Asn Leu Glu Asp Ser Gln Ile Val Ser Lys 
            420                 425                 430         


Pro Glu Ile Lys Gln Leu Phe His Ile Ser Tyr Gly Val Leu Leu Glu 
        435                 440                 445             


Glu Arg Lys Lys Gln Ile Phe Glu Val Leu Asn Lys Tyr Glu Glu Glu 
    450                 455                 460                 


His Tyr Glu Phe Val Arg Lys Asn Ile Glu Asn His Phe Lys Glu Ile 
465                 470                 475                 480 


Phe Ser Lys 
            


<210>  354
<211>  499
<212>  PRT
<213>  Mesotoga infera

<400>  354

Met Lys Glu Asn Lys Val Met Asn Ser Phe Ser Ala Ile Tyr Gly Asn 
1               5                   10                  15      


Arg Tyr Lys Val Tyr Glu Lys Ser Leu Lys Arg Lys Glu Lys Glu Phe 
            20                  25                  30          


Phe Phe Val Ile Lys Asp Phe Gln Arg Lys Tyr Leu Val Ala Ala Gly 
        35                  40                  45              


Pro Ser Tyr Arg Ile Arg Lys Arg Asp Phe Gln Pro Asp Glu Glu Gly 
    50                  55                  60                  


Val Ala Asp Asn Glu Gly Glu Phe Leu Phe Gln Ile Cys Arg Leu Thr 
65                  70                  75                  80  


His His Asn Leu Thr Gln Leu Gln Ser Ile Phe Asn Tyr Leu Gln Pro 
                85                  90                  95      


Ser Thr Thr Lys Met Lys Pro Ser Phe Gly Thr Gly Asp Arg Leu Gly 
            100                 105                 110         


Ile Ala Thr Pro Ala His Ile Gln Ala Phe Glu Asp Lys Asn Ile Phe 
        115                 120                 125             


Pro Ile Leu Ala Gln Gln Ser Val Arg Glu Met Glu Arg Thr Glu Ser 
    130                 135                 140                 


Asn Trp Gln Lys Val Leu Asp Asn Ala Ile Trp Gly Cys Phe Glu Ala 
145                 150                 155                 160 


Gly Tyr Glu Gly Lys Phe Gly Ala Asp Ala Asp His Val Lys Asp Leu 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Ile Asp Cys Gly Phe Thr Phe Tyr Thr Ile 
            180                 185                 190         


Asp Pro Ser Asp His Ile Asp Ala Asn Ile Leu Lys Leu Asp Lys Asp 
        195                 200                 205             


Glu Leu Arg Asn Lys Tyr Gln Gln Leu Pro Glu Lys Asp Ala Leu Glu 
    210                 215                 220                 


Asn Ser Tyr Leu Asn Lys Glu Tyr Gln Ile Gly Ser Gln Lys Leu Thr 
225                 230                 235                 240 


Phe Thr Gln Asp Ile Leu Ile Glu Ile Val Leu Thr Tyr Leu Glu Ala 
                245                 250                 255     


Ile Lys His Val Glu Lys Cys Tyr Lys Phe Leu Lys Asp Ser His Lys 
            260                 265                 270         


Gly Asp Phe Glu Leu Glu Val Ser Val Asp Glu Thr Pro Thr Pro Thr 
        275                 280                 285             


Ser Pro Leu Ala His Leu Trp Ile Ala Ser Glu Leu Gln Arg Arg Gly 
    290                 295                 300                 


Val Asp Phe Gln Asn Leu Ala Pro His Phe Ile Gly Asp Trp Glu Lys 
305                 310                 315                 320 


Gly Ile Asp Tyr Ile Gly Asn Ile Asp Thr Phe Lys Glu Glu Phe Lys 
                325                 330                 335     


Leu His Cys Gln Ile Ala Ser Gln Met Gly Gly Tyr Lys Leu Ser Leu 
            340                 345                 350         


His Ser Gly Ser Asp Lys Phe Ser Val Tyr Pro Ile Phe Ala Glu Glu 
        355                 360                 365             


Thr Asn Gly Tyr Phe His Val Lys Thr Ala Gly Thr Ser Trp Leu Glu 
    370                 375                 380                 


Ala Val Lys Ala Ile Val Val Cys Asp Pro Ala Leu Tyr Arg Glu Met 
385                 390                 395                 400 


Tyr Glu Phe Ala Leu Lys Cys Phe Glu Lys Asp Ser Phe Ser Tyr Leu 
                405                 410                 415     


Leu Ser Thr Asp Leu Gln Lys Ile Pro Asn Ile Lys Glu Leu Gln Asp 
            420                 425                 430         


Lys Glu Leu Ile Gln Leu Phe Ser Asn Asn Asn Ala Arg Gln Leu Ile 
        435                 440                 445             


His Ile Thr Tyr Gly Ser Ile Leu Arg Glu Lys Asp Ser Gln Asn Arg 
    450                 455                 460                 


Tyr Lys Phe Arg Asp Arg Ile Tyr Lys Val Leu Phe Glu Asn Glu Asp 
465                 470                 475                 480 


Ile His Tyr Glu Asn Val Ser Lys His Ile Arg His His Leu Gly Leu 
                485                 490                 495     


Leu Ser Val 
            


<210>  355
<211>  502
<212>  PRT
<213>  Thermosinus carboxydivorans

<400>  355

Met Gln Ser Arg Glu Glu Leu Lys Arg Ala Ile Leu Ser Glu Phe Gly 
1               5                   10                  15      


Asp Tyr Asn Ile Tyr Ser Glu Ser Ile Tyr Arg Ala Gly Gly Cys Val 
            20                  25                  30          


Leu Phe Leu Ala Lys Asp Met Gly Gln Lys Leu Leu Val Val Val Glu 
        35                  40                  45              


Glu Glu Thr Gly Ser Ala Phe Asp Arg Phe Val Gly Pro Gln Val Tyr 
    50                  55                  60                  


His Pro Ser Gly Lys Arg Val Lys Glu Ala Pro Leu Gln Pro Val Asn 
65                  70                  75                  80  


Ala Gly Ile Val Arg Glu Leu Leu Pro Phe Thr Ala Pro Val Ala Leu 
                85                  90                  95      


Gly Ala Thr Gly Leu Ser Leu Gly Leu Gly Asp Arg Leu Gly Val Ala 
            100                 105                 110         


Ser Pro Gly His Leu Arg Leu Ile Lys Lys Thr Gly Val Arg Pro Val 
        115                 120                 125             


Leu Ala Gln Gln Ser Val Arg Glu Leu Thr Leu Thr Asn Arg Thr Tyr 
    130                 135                 140                 


Ser Asp Val Leu Asp Ala Ala Thr Trp Ala Val Leu Gln Glu Gly Tyr 
145                 150                 155                 160 


Glu Gly Gly Phe Gly Ala Asp Gly Asp His Leu Lys Thr Ala Glu Glu 
                165                 170                 175     


Ile Lys Gly Ala Leu Asp Leu Gly Phe Thr Met Ile Thr Leu Asp Ala 
            180                 185                 190         


Ser Ala His Ile Asp Asn Thr Val Gly Gln Lys Ala Ala Lys Gln Val 
        195                 200                 205             


Ala Glu Leu Tyr His Thr Leu Pro Ala Asp Tyr Thr Ala Asp Met Glu 
    210                 215                 220                 


Glu His Tyr Leu Gly Lys Ala Phe Ile Val Gly Gly Met Ala Ile Thr 
225                 230                 235                 240 


Phe Asp Thr Glu Thr Leu Gln Arg Leu Val Leu Thr Tyr Gly Lys Ala 
                245                 250                 255     


Leu Ala Phe Met Gly Tyr Ile Tyr His Thr Leu Ile Val Asn Ala Gly 
            260                 265                 270         


Arg Glu Val Asp Phe Glu Ile Ser Ile Asp Glu Thr Ala Thr Pro Thr 
        275                 280                 285             


Thr Pro Ala Ala His Tyr Phe Val Ala Ser Glu Leu Gly Arg Met Gly 
    290                 295                 300                 


Val Lys Phe Thr Ser Leu Ala Pro Arg Phe Cys Gly Glu Phe Gln Lys 
305                 310                 315                 320 


Gly Ile Asp Tyr Ile Gly Asp Leu Tyr Gln Phe Glu Asp Glu Phe Lys 
                325                 330                 335     


Arg His Ala Ala Ile Ala Asp His Phe Gly Tyr Arg Leu Ser Ile His 
            340                 345                 350         


Ser Gly Ser Asp Lys Phe Ser Val Phe Pro Ile Ile Gly Gln Tyr Thr 
        355                 360                 365             


Arg Gly Arg Val His Ile Lys Thr Ala Gly Thr Asn Trp Leu Glu Ala 
    370                 375                 380                 


Leu Arg Val Val Ala Arg Ile Asn Pro Ala Leu Phe Arg Glu Ile Tyr 
385                 390                 395                 400 


Ala Phe Ala Gly Glu Val Phe Gly Glu Ala Lys Lys Tyr Tyr His Val 
                405                 410                 415     


Thr Thr Asp Leu Thr Arg Leu Pro Asp Val Ala Ala Met Ala Asp Asp 
            420                 425                 430         


Gly Leu Pro Thr Val Leu Asp His Asn Asp Ala Arg Gln Met Leu His 
        435                 440                 445             


Ile Thr Tyr Gly Leu Val Leu Thr Ala Ala Asn Ala Asp Gly Ser Tyr 
    450                 455                 460                 


Arg Phe Lys Asp Ala Leu Tyr Glu Leu Leu Phe Asp His Glu Asp Glu 
465                 470                 475                 480 


Tyr Tyr Ala Ala Leu Glu Arg His Ile Gly Arg His Leu Glu Lys Leu 
                485                 490                 495     


Thr Glu Asn Leu Lys Gly 
            500         


<210>  356
<211>  507
<212>  PRT
<213>  Halanaerobium congolense

<400>  356

Met Ser Trp Lys Asp Phe Ala Glu Glu Leu Val Gly Thr Ser Lys Glu 
1               5                   10                  15      


Ala Val Met Lys Val Ala Glu Tyr Ala Glu Asp Tyr Arg Ile Tyr Pro 
            20                  25                  30          


Arg Ser Ile Ile Lys Lys Asp Lys Ser Phe Tyr Phe Leu Ala Lys Ile 
        35                  40                  45              


Asp Gln Lys Lys Lys Leu Val Ile Leu Asn Lys Ser Lys Asn Phe Glu 
    50                  55                  60                  


Leu Phe Gln Gly Arg Ile Glu Glu Leu Ala Gly Phe Lys Ala Lys Ile 
65                  70                  75                  80  


Gly Pro Leu Ser His Tyr Asn Ala Glu Ile Leu Arg Glu Val Phe Pro 
                85                  90                  95      


Phe Thr Ala Pro Ser Ala Leu Gly Asn Lys Lys Pro Ser Ile Gly Leu 
            100                 105                 110         


Gly Asp Arg Leu Gly Ile Ala Thr Pro Gly His Ile Glu Ala Val Lys 
        115                 120                 125             


Glu Ser Ala Ala Met Pro Val Phe Ala Gln Gln Ser Val Arg Glu Leu 
    130                 135                 140                 


Asn Leu Thr Gly Arg Thr Phe Lys Ser Val Leu Asp Asp Val Ser Trp 
145                 150                 155                 160 


Ala Val Phe Gln Glu Gly Tyr Gln Ala Gly Phe Ala Ala Asp Ala Asp 
                165                 170                 175     


His Leu Lys Glu Lys Pro Asp Ile Lys Glu Ala Leu Asp Leu Gly Tyr 
            180                 185                 190         


Thr Met Leu Thr Leu Asp Cys Thr Asp Tyr Ile Asn Asp Asp Leu Asp 
        195                 200                 205             


Gln Met Ser Glu Ser Glu Ile Glu Asn Ala Tyr Ala Glu Val Pro Asp 
    210                 215                 220                 


Tyr Leu Arg Glu Gly Leu Glu Asn Gln Tyr Leu Asn Lys Thr Phe Val 
225                 230                 235                 240 


Leu Asn Ser Gly Tyr Gln Leu Glu Tyr Asn Gln Asp Asn Phe Lys Glu 
                245                 250                 255     


Ile Val Leu Ile Tyr Tyr Lys Met Leu Asp Phe Ala Lys Glu Ile Gln 
            260                 265                 270         


His Leu Ile Lys Thr Ser Ala Arg Asn Val Asp Phe Glu Ile Ser Ile 
        275                 280                 285             


Asp Glu Thr Ser Thr Pro Thr Thr Pro Glu Ala His Phe Phe Val Ala 
    290                 295                 300                 


Asn Glu Leu Lys Arg Asn Asn Ile Glu Val Asn Ser Leu Ala Pro Arg 
305                 310                 315                 320 


Phe Val Gly Glu Phe Gln Lys Gly Ile Asp Tyr Ile Gly Asp Leu Glu 
                325                 330                 335     


Gln Phe Glu Lys Glu Phe Lys Val His Ala Asp Ile Ala Asp Arg Phe 
            340                 345                 350         


Gly Tyr Lys Leu Ser Ile His Ser Gly Ser Asp Lys Phe Ser Val Phe 
        355                 360                 365             


Pro Ile Ile Gly Arg His Thr Gln Gly Arg Val His Val Lys Thr Ala 
    370                 375                 380                 


Gly Thr Asn Trp Leu Glu Ala Ile Arg Val Val Ala Glu Asn Asn Pro 
385                 390                 395                 400 


Ser Leu Tyr Arg Asp Ile His Ala Tyr Ala Leu Lys Lys Phe Glu Ala 
                405                 410                 415     


Ala Lys Glu Tyr Tyr His Val Thr Thr Asp Leu Asp Lys Val Pro Glu 
            420                 425                 430         


Leu Ala Arg Met Ser Asp Gln Glu Leu Gly Glu Leu Leu Glu Ile Asn 
        435                 440                 445             


Glu Val Arg Gln Leu Leu His Ile Thr Tyr Gly Phe Ile Leu Gln Asp 
    450                 455                 460                 


Lys Lys Asp Gly Arg Tyr Ile Phe Arg Asp Lys Leu Tyr Lys Phe Trp 
465                 470                 475                 480 


Asp Glu Tyr Asp Lys Glu Tyr Arg Arg Ala Leu Glu Arg His Ile Gly 
                485                 490                 495     


Arg His Leu Asn Lys Leu Gly Phe Tyr Lys Asn 
            500                 505         


<210>  357
<211>  507
<212>  PRT
<213>  Halanaerobium congolense

<400>  357

Met Ser Trp Lys Asp Phe Ala Glu Glu Leu Val Gly Thr Ser Lys Glu 
1               5                   10                  15      


Ala Val Met Lys Val Ala Glu Tyr Ala Glu Asp Tyr Arg Ile Tyr Pro 
            20                  25                  30          


Arg Ser Ile Ile Lys Lys Asp Lys Ser Phe Tyr Phe Leu Ala Lys Ile 
        35                  40                  45              


Asp Gln Lys Lys Lys Leu Val Ile Leu Asn Lys Ser Lys Asn Phe Glu 
    50                  55                  60                  


Leu Phe Gln Gly Arg Ile Glu Glu Leu Ala Gly Phe Lys Ala Lys Ile 
65                  70                  75                  80  


Gly Pro Leu Ser His Tyr Asn Ala Glu Ile Leu Arg Lys Val Phe Pro 
                85                  90                  95      


Phe Thr Ala Pro Ser Ala Leu Gly Asn Lys Lys Pro Ser Ile Gly Leu 
            100                 105                 110         


Gly Asp Arg Leu Gly Ile Ala Thr Pro Gly His Ile Glu Ala Val Lys 
        115                 120                 125             


Glu Ser Ala Ala Met Pro Val Phe Ala Gln Gln Ser Val Arg Glu Leu 
    130                 135                 140                 


Asn Leu Thr Gly Arg Thr Phe Lys Ser Val Leu Asp Asp Val Ser Trp 
145                 150                 155                 160 


Ala Val Phe Gln Glu Gly Tyr Gln Ala Gly Phe Ala Ala Asp Ala Asp 
                165                 170                 175     


His Leu Lys Glu Lys Pro Asp Ile Lys Glu Ala Leu Asp Leu Gly Tyr 
            180                 185                 190         


Thr Met Leu Thr Leu Asp Cys Thr Asp Tyr Ile Asn Asp Asp Leu Asp 
        195                 200                 205             


Gln Met Ser Glu Ser Glu Val Glu Asn Ala Tyr Ala Glu Val Pro Asp 
    210                 215                 220                 


Tyr Leu Arg Glu Gly Leu Glu Asn Gln Tyr Leu Asn Lys Thr Phe Val 
225                 230                 235                 240 


Leu Asn Ser Gly Tyr Gln Leu Glu Tyr Asn Gln Asp Asn Phe Lys Glu 
                245                 250                 255     


Ile Val Leu Ile Tyr Tyr Lys Met Leu Asp Phe Ala Lys Glu Ile Gln 
            260                 265                 270         


His Leu Ile Lys Thr Ser Ala Arg Asn Val Asp Phe Glu Ile Ser Ile 
        275                 280                 285             


Asp Glu Thr Ser Thr Pro Thr Thr Pro Glu Ala His Phe Phe Val Ala 
    290                 295                 300                 


Asn Glu Leu Lys Arg Asn Asn Ile Glu Val Asn Ser Leu Ala Pro Arg 
305                 310                 315                 320 


Phe Val Gly Glu Phe Gln Lys Gly Ile Asp Tyr Ile Gly Asp Leu Glu 
                325                 330                 335     


Gln Phe Glu Lys Glu Phe Lys Val His Ala Asp Ile Ala Asp Arg Phe 
            340                 345                 350         


Gly Tyr Lys Leu Ser Ile His Ser Gly Ser Asp Lys Phe Ser Val Phe 
        355                 360                 365             


Pro Ile Ile Gly Arg His Thr Gln Gly Arg Val His Val Lys Thr Ala 
    370                 375                 380                 


Gly Thr Asn Trp Leu Glu Ala Ile Arg Val Val Ala Glu Asn Asn Pro 
385                 390                 395                 400 


Ser Leu Tyr Arg Asp Ile His Ala Tyr Ala Leu Lys Lys Phe Glu Ala 
                405                 410                 415     


Ala Lys Glu Tyr Tyr His Val Thr Thr Asp Leu Asp Lys Val Pro Glu 
            420                 425                 430         


Leu Ala Arg Met Ser Asp Gln Glu Leu Gly Glu Leu Leu Glu Ile Asn 
        435                 440                 445             


Glu Val Arg Gln Leu Leu His Ile Thr Tyr Gly Phe Ile Leu Gln Asp 
    450                 455                 460                 


Lys Lys Asp Gly Arg Tyr Ile Phe Arg Asp Lys Leu Tyr Lys Phe Trp 
465                 470                 475                 480 


Asp Glu Tyr Asp Lys Glu Tyr Arg Arg Ala Leu Glu Arg His Ile Gly 
                485                 490                 495     


Arg His Leu Asn Lys Leu Gly Phe Tyr Lys Asn 
            500                 505         


<210>  358
<211>  507
<212>  PRT
<213>  Halanaerobium saccharolyticum

<400>  358

Met Ser Trp Lys Asp Phe Ala Glu Glu Leu Val Gly Thr Ser Lys Asp 
1               5                   10                  15      


Ala Val Lys Lys Val Ala Glu Tyr Ala Glu Asp Tyr Arg Ile Tyr Pro 
            20                  25                  30          


Arg Ser Ile Ile Lys Lys Glu Lys Ser Phe Tyr Phe Leu Ala Lys Ile 
        35                  40                  45              


Asp Gln Lys Lys Lys Leu Val Ile Leu Asn Lys Ser Lys Asn Phe Asp 
    50                  55                  60                  


Ile Phe Gln Gly Lys Thr Glu Lys Leu Ala Gly Phe Lys Ala Lys Ile 
65                  70                  75                  80  


Ala Pro Leu Ser His Tyr Asn Ala Glu Ile Ile Arg Glu Val Phe Pro 
                85                  90                  95      


Phe Thr Ala Pro Ser Lys Ile Gly Asn Gln Thr Ala Ser Ile Gly Leu 
            100                 105                 110         


Gly Asp Arg Leu Gly Ile Ala Thr Pro Gly His Ile Glu Ala Val Lys 
        115                 120                 125             


Lys Ser Asn Ala Met Pro Val Phe Ala Gln Gln Ser Val Lys Glu Leu 
    130                 135                 140                 


Lys Leu Thr Gly Arg Ser Phe Lys Ser Val Leu Asp Asp Val Ser Trp 
145                 150                 155                 160 


Ala Val Phe Gln Glu Gly Tyr Gln Asn Gly Phe Gly Ala Asp Ala Asp 
                165                 170                 175     


Arg Leu Lys Glu Lys Pro Glu Ile Lys Glu Ala Leu Asp Leu Gly Tyr 
            180                 185                 190         


Thr Met Leu Thr Leu Asp Cys Thr Asp Tyr Ile Asn Asp Asn Phe Asp 
        195                 200                 205             


Gln Thr Ala Glu Ser Asp Ile Glu Ser Ala Tyr Ala Glu Val Pro Asp 
    210                 215                 220                 


Tyr Leu Arg Asp Gly Leu Glu Ser Lys Tyr Leu Asn Lys Thr Phe Val 
225                 230                 235                 240 


Leu Asn Ser Gly Tyr Gln Leu Glu Tyr Asn Lys Val Asn Phe Lys Lys 
                245                 250                 255     


Ile Val Leu Ser Tyr Tyr Gln Ile Leu Asp Phe Val Lys Glu Ile Gln 
            260                 265                 270         


His Leu Ile Lys Arg Ser Ala Arg Asp Val Asp Leu Glu Ile Ser Ile 
        275                 280                 285             


Ala Asp Ser Leu Asn Ser Thr Ser Pro Glu Ala His Phe Phe Val Ala 
    290                 295                 300                 


Asn Glu Phe Lys Arg Asn Asn Ile Glu Val Asn Ser Leu Ala Leu Asn 
305                 310                 315                 320 


Phe Val Gly Glu Phe Gln Lys Gly Ile Asp Tyr Ile Gly Asp Leu Glu 
                325                 330                 335     


Lys Phe Glu Lys Asp Phe Glu Ile His Ala Asp Ile Ala Asp Arg Phe 
            340                 345                 350         


Gly Tyr Lys Leu Ser Ile His Ser Gly Ser Asp Lys Phe Ser Ile Phe 
        355                 360                 365             


Pro Ile Ile Gly Arg Gln Thr Glu Gly Arg Ala His Ile Lys Thr Ala 
    370                 375                 380                 


Gly Thr Asn Trp Leu Glu Ala Ile Arg Val Val Ala Glu Asn Asp Pro 
385                 390                 395                 400 


Ser Leu Tyr Arg Glu Ile His Ser Tyr Ala Leu Lys Lys Phe Glu Glu 
                405                 410                 415     


Ala Lys Glu Phe Tyr Gln Val Asn Thr Asp Leu Ser Lys Val Pro Glu 
            420                 425                 430         


Leu Ala Val Met Ser Asp Gln Glu Leu Gly Glu Leu Leu Glu Ile Asp 
        435                 440                 445             


Ala Val Arg Gln Leu Leu His Ile Thr Tyr Gly Phe Ile Leu Gln Asp 
    450                 455                 460                 


Lys Lys Asp Gly Arg Tyr Ile Phe Arg Asp Arg Leu Tyr Lys Leu Leu 
465                 470                 475                 480 


Asp Glu Tyr Asp Lys Asp Tyr Arg Ser Gly Leu Glu Arg His Ile Gly 
                485                 490                 495     


Arg His Leu Asn Lys Leu Gly Phe Tyr Lys Asn 
            500                 505         


<210>  359
<211>  504
<212>  PRT
<213>  Gracilibacillus halophilus

<400>  359

Met Val Lys His Phe Glu Ser Val Leu Glu Glu Leu Ser Gln Arg Lys 
1               5                   10                  15      


Val Pro Thr Ser Thr Glu Glu Val Thr Val Tyr Thr Pro Ser Phe Glu 
            20                  25                  30          


Glu His Ala Gly Ser Gln Val Val Met Val Lys Ser Gly Thr Glu Lys 
        35                  40                  45              


Met Ile Val Ala Ala Gly Ala Gly Glu Leu Phe Glu Ala Leu Ser Gly 
    50                  55                  60                  


Glu Asp Ile Gly Lys Gly Lys Val Cys Pro Leu Thr His Glu Asn Arg 
65                  70                  75                  80  


Leu Val Leu Asn Gln Phe Phe Ser Tyr Thr Ala Pro Gln Ala Phe Gly 
                85                  90                  95      


Thr Asp Ile Ala Thr Met Gly Leu Gly Asp Arg Leu Gly Ile Ala Ser 
            100                 105                 110         


Pro Gly His Ile Asp Thr Val Lys Glu Arg Asn Val Lys Pro Ile Leu 
        115                 120                 125             


Ala Gln Gln Ser Ile Arg Glu Leu Thr Leu Leu Asn Arg Thr Met Thr 
    130                 135                 140                 


Asp Ile Leu Asp Ala Ala Ala Phe Ala Val Phe Gln Glu Gly Tyr Lys 
145                 150                 155                 160 


Asp Gly Tyr Gly Ala Asp Ala Asp His Ile Lys Leu Glu Ser Asp Ile 
                165                 170                 175     


Glu His Ala Leu Gln Leu Gly Phe Ser Phe Leu Thr Leu Asp Cys Ser 
            180                 185                 190         


Glu Gln Ile Arg Asn Asp Val Glu Ser Gln Thr Ser Asp Glu Ile Gln 
        195                 200                 205             


Asn Glu Phe Ala Ser Leu Ser Asp Glu Lys Arg Ala Tyr Phe Ser Asn 
    210                 215                 220                 


Tyr Tyr Leu Asp Gln Thr Phe Asn Val His Glu Arg Gln Ile Ser Phe 
225                 230                 235                 240 


Asp Gln Ala Asn Leu Ala Lys Asn Val Leu Val Tyr Gly Glu Ala Ile 
                245                 250                 255     


Asp Phe Met Glu His Val Tyr His Thr Tyr Leu Gln Ser Leu Asp Arg 
            260                 265                 270         


Asp Val Asp Phe Glu Ile Ser Ile Asp Glu Thr Glu Thr Val Thr Ser 
        275                 280                 285             


Pro Glu Ala His Phe Phe Val Ala Glu Glu Leu Arg Arg Arg Gly Val 
    290                 295                 300                 


Lys Val Glu Ser Leu Ala Pro Arg Phe Cys Gly Glu Phe Gln Lys Gly 
305                 310                 315                 320 


Ile Asp Tyr Ile Gly Asp Met Asp Gln Phe Glu Lys Glu Leu Lys Glu 
                325                 330                 335     


His Ala Asp Ile Ala Lys His Phe Gly Tyr Lys Leu Ser Ile His Ser 
            340                 345                 350         


Gly Ser Asp Lys Phe Ser Val Phe Pro Ile Ile Gly Lys Tyr Thr Asp 
        355                 360                 365             


Gly Leu Leu His Ile Lys Thr Ala Gly Thr Asn Trp Leu Glu Ala Val 
    370                 375                 380                 


Arg Val Val Ala Gln Glu Asn Pro Asp Leu Tyr Arg Arg Met His Val 
385                 390                 395                 400 


Tyr Ala Glu Glu His Phe Glu Glu Thr Leu Lys Tyr Tyr His Val Thr 
                405                 410                 415     


Pro Asp Leu Asp Ser Val Thr Pro Leu Lys Glu Gln Pro Asp Asp Gln 
            420                 425                 430         


Leu Pro Glu Tyr Met Asn His Asp Ala Ala Arg Gln Leu Phe His Val 
        435                 440                 445             


Thr Tyr Gly Ile Leu Leu Thr Ala Lys Asp Asp Ala Gly Asn Asp Leu 
    450                 455                 460                 


Phe Arg Asp Glu Phe Phe Asp Thr Leu Leu Asn Lys Glu Asp Ala Tyr 
465                 470                 475                 480 


Arg Gln Ala Leu Ala His His Ile Gly Arg His Leu Asp Leu Leu Gly 
                485                 490                 495     


Leu Ser Lys Lys Val Gly Ile Glu 
            500                 


<210>  360
<211>  483
<212>  PRT
<213>  Caldanaerobacter subterraneus

<400>  360

Met Ile Asn Lys Val Ala Glu Tyr Leu Ser Arg Glu Gly Phe His Phe 
1               5                   10                  15      


Tyr Glu Lys Ser Phe Arg Lys Phe Ser Glu Asp Ile Tyr Ile Phe Val 
            20                  25                  30          


Val Lys Lys Ala Asn Glu Lys Ser Ile Gly Leu Leu Thr Gln Arg Asp 
        35                  40                  45              


Phe Thr Leu Ser Ser Pro Tyr Phe Thr Glu Arg Lys Tyr Leu Lys Glu 
    50                  55                  60                  


Ile Gly Tyr Tyr Leu Asn Leu Tyr Pro Leu Thr Tyr Glu Asn Phe Val 
65                  70                  75                  80  


Ile Leu Lys Asp Lys Phe Ser Ile Ala Pro Ser Pro Cys Asn Lys Lys 
                85                  90                  95      


Val Ser Phe Gly Met Gly Asp Arg Leu Gly Leu Val Thr Ala Ala His 
            100                 105                 110         


Ile Arg Ala Val Gln Asn Tyr Asp Val Phe Pro Val Leu Ala Gln Gln 
        115                 120                 125             


Ser Pro Arg Glu Leu Met Lys Thr His Arg Ser Phe Arg Glu Ala Ile 
    130                 135                 140                 


Leu Lys Ala Ile Leu Gly Val Leu Glu Glu Gly Tyr Thr Gly Lys Phe 
145                 150                 155                 160 


Gly Ala Asp Ala Asp His Ile Lys Asp Glu Asn Tyr Leu Met Glu Ala 
                165                 170                 175     


Ile Asp Ala Gly Tyr Thr Met Tyr Thr Leu Asp Leu Ser Asp Met Leu 
            180                 185                 190         


Val Lys Leu Ser Asp Tyr Thr Glu Ser Gln Leu Lys Glu Lys Ala Glu 
        195                 200                 205             


Lys Leu Asn Ile Thr Ser Lys Arg Ile Ile Glu Lys Phe Lys Gly Lys 
    210                 215                 220                 


Lys Phe Val Met Pro Thr Glu Glu Ala Phe Thr Val Ser Glu Glu Glu 
225                 230                 235                 240 


Leu Tyr Lys Ser Ala Leu Thr Tyr Glu Lys Ala Met Asp Phe Val Glu 
                245                 250                 255     


Lys Val Tyr Gly Ile Leu Lys Asp Lys Val Lys Asn Phe Asp Leu Glu 
            260                 265                 270         


Ile Ser Ile Asp Glu Gly Asp Lys Asp Thr Thr Val Glu Asp His Ile 
        275                 280                 285             


Phe Val Ala Glu Tyr Leu His Glu Lys Gly Ile Asp Phe Trp Ser Leu 
    290                 295                 300                 


Ala Pro Lys Phe Pro Gly Glu Phe Gln Lys Ala Ile Asp Tyr Ile Gly 
305                 310                 315                 320 


Asp Val Asp Lys Phe Ala Val Glu Leu Lys Lys His Gln Phe Leu Ser 
                325                 330                 335     


Arg Glu Phe Gly Gly Tyr Lys Leu Ser Leu His Ser Gly Ser Asp Lys 
            340                 345                 350         


Phe Ser Ile Tyr Lys Val Phe Ser Glu Ile Thr Glu Arg Glu Phe His 
        355                 360                 365             


Ile Lys Thr Ser Gly Thr Ser Trp Leu Gln Ala Val Asn Leu Ile Phe 
    370                 375                 380                 


Glu Lys Asp Lys Lys Leu Phe Lys Glu Leu Tyr Gln Ile Ala Leu Tyr 
385                 390                 395                 400 


Asn Leu Glu Glu Ser Lys Lys Ala Tyr Lys Val Leu Ile Asp Lys Lys 
                405                 410                 415     


Asp Phe Pro Glu Asn Ile Asn Leu Glu Asp Ser Gln Ile Val Ser Lys 
            420                 425                 430         


Pro Glu Ile Lys Gln Leu Phe His Ile Ser Tyr Gly Val Leu Leu Glu 
        435                 440                 445             


Glu Arg Lys Lys Gln Ile Phe Glu Val Leu Asn Lys Tyr Glu Glu Glu 
    450                 455                 460                 


His Tyr Glu Phe Val Arg Lys Asn Ile Glu Asn His Phe Lys Glu Ile 
465                 470                 475                 480 


Phe Ser Lys 
            


<210>  361
<211>  418
<212>  PRT
<213>  Litorilinea aerophila

<400>  361

Met Leu Pro Tyr Leu Val Ala Arg Pro Leu Gly Leu Arg Lys Ser Ala 
1               5                   10                  15      


Gly Cys Gly Asp Arg Leu Gly Leu Ala Thr Pro Gly His Ile Arg Ala 
            20                  25                  30          


Leu Arg Ala Thr Phe Gly Arg Asp Glu Asp Ala Ala Met Ala Pro Ile 
        35                  40                  45              


Phe Ala Gln Gln Ser Ile Arg Glu Asn Ala Arg Thr Gly Arg Thr Pro 
    50                  55                  60                  


Gln Glu Val Met Asp Asp Ala Met Trp Gly Val Phe Gln Glu Gly Trp 
65                  70                  75                  80  


Arg Ala Gly Phe Gly Ala Asp Ala Asp His Leu Lys Thr Leu Ala Asp 
                85                  90                  95      


Val Asp Ile Cys Ala Ala Ala Gly Tyr Thr Phe Tyr Thr Val Asp Pro 
            100                 105                 110         


Gly Asp His Val Asp Asp Glu Ala Asn Thr Ala Ala Phe Pro Ala Leu 
        115                 120                 125             


Glu Ala Arg Val Asp Ala Leu Pro Trp Asp Val Leu Asp Ser Ser Pro 
    130                 135                 140                 


Ala Asp Leu Ala Ala Arg Leu Ala Asp Arg Pro Ile Asp Leu Gly Thr 
145                 150                 155                 160 


Leu Lys Val Thr Leu Asp Arg Glu Thr Leu Trp Arg Ala Ala Ala Lys 
                165                 170                 175     


Tyr Gly Arg Ala Val Ala His Thr Val Thr Met Tyr Arg His Leu Ala 
            180                 185                 190         


Gly Ala Met Gly Glu Arg Pro Phe Glu Leu Glu Met Ser Val Asp Glu 
        195                 200                 205             


Thr Ala Thr Val Thr Ser Leu Ala Glu His Val Tyr Ile Ala Ala Glu 
    210                 215                 220                 


Leu Gln Arg Leu Gly Val Arg Cys Val Ser Leu Ala Pro Arg Tyr Val 
225                 230                 235                 240 


Gly Thr Phe Glu Lys Gly Val Asp Tyr Ile Gly Asp Leu Asp Ala Phe 
                245                 250                 255     


Glu Gln Ser Ile Ala Gln His Met Ala Val Ser Arg Thr Phe Gly Pro 
            260                 265                 270         


Tyr Lys Leu Ser Leu His Ser Gly Ser Asp Lys Phe Ser Ile Tyr Pro 
        275                 280                 285             


Ile Ala Ser Arg Val Ala Gly Asp Leu Val His Leu Lys Thr Ala Gly 
    290                 295                 300                 


Thr Ser Tyr Leu Glu Ala Leu Arg Ala Ile Ala Ala Met Ala Pro Asp 
305                 310                 315                 320 


Leu Phe Arg Gln Ile Val Ala Phe Ala Arg Glu Arg Tyr Pro Thr Asp 
                325                 330                 335     


Arg Ala Ser Tyr His Val Ser Ala Glu Leu Glu Lys Met Pro Asp Ile 
            340                 345                 350         


Ala Gly Trp Pro Asp Asp Arg Leu Pro Glu Leu Leu Asn Asp Phe His 
        355                 360                 365             


Ala Arg Glu Ile Leu His Val Thr Phe Gly Ser Val Leu Asn His Pro 
    370                 375                 380                 


Pro Phe Arg Glu Pro Phe Phe Thr Ala Leu Arg Thr His Glu Glu Thr 
385                 390                 395                 400 


Tyr Ser Glu Met Leu Glu Arg His Phe Cys Arg His Phe Ala Pro Phe 
                405                 410                 415     


Ala Gly 
        


<210>  362
<211>  483
<212>  PRT
<213>  Caldanaerobacter subterraneus

<400>  362

Met Ile Asn Lys Val Ala Glu Tyr Leu Ser Arg Glu Gly Phe Tyr Phe 
1               5                   10                  15      


Tyr Glu Lys Ser Phe Arg Lys Phe Ser Glu Asp Ile Tyr Ile Phe Val 
            20                  25                  30          


Val Lys Lys Ala Asn Glu Lys Ser Ile Gly Leu Leu Thr Gln Gly Asp 
        35                  40                  45              


Phe Thr Leu Ser Ser Pro Tyr Phe Thr Glu Arg Lys Tyr Leu Lys Glu 
    50                  55                  60                  


Ile Gly Tyr Tyr Leu Asn Leu Tyr Pro Leu Thr Tyr Glu Asn Phe Val 
65                  70                  75                  80  


Ile Leu Lys Asp Lys Phe Ser Ile Ala Pro Ser Pro Cys Asn Lys Lys 
                85                  90                  95      


Val Ser Phe Gly Met Gly Asp Arg Leu Gly Leu Val Thr Ala Ala His 
            100                 105                 110         


Ile Arg Ala Val Glu Asn Tyr Asp Val Phe Pro Val Leu Ala Gln Gln 
        115                 120                 125             


Ser Pro Arg Glu Leu Met Lys Thr His Arg Ser Phe Lys Glu Ala Ile 
    130                 135                 140                 


Leu Lys Ala Ile Leu Gly Val Leu Glu Glu Gly Tyr Thr Gly Lys Phe 
145                 150                 155                 160 


Gly Ala Asp Ala Asp His Ile Lys Asp Glu Asn Tyr Leu Met Glu Ala 
                165                 170                 175     


Ile Asp Ala Gly Tyr Thr Met Tyr Thr Leu Asp Leu Ser Asp Met Leu 
            180                 185                 190         


Val Lys Leu Ser Asp Tyr Thr Glu Ser Gln Leu Lys Glu Lys Ala Glu 
        195                 200                 205             


Lys Leu Asn Ile Thr Ser Lys Arg Ile Ile Glu Arg Phe Lys Gly Lys 
    210                 215                 220                 


Lys Phe Val Met Pro Thr Lys Glu Ala Phe Thr Val Ser Glu Glu Glu 
225                 230                 235                 240 


Leu Tyr Lys Ser Ala Leu Thr Tyr Glu Lys Ala Met Asp Phe Val Glu 
                245                 250                 255     


Lys Val Tyr Gly Ile Leu Lys Asp Lys Val Lys Asn Phe Asp Leu Glu 
            260                 265                 270         


Ile Ser Ile Asp Glu Gly Asp Lys Asp Thr Thr Val Glu Asp His Ile 
        275                 280                 285             


Phe Val Ala Glu Tyr Leu His Glu Lys Gly Ile Asp Phe Trp Ser Leu 
    290                 295                 300                 


Ala Pro Lys Phe Pro Gly Glu Phe Gln Lys Ala Ile Asp Tyr Ile Gly 
305                 310                 315                 320 


Asp Val Asp Lys Phe Ala Val Glu Leu Lys Lys His Gln Phe Leu Ser 
                325                 330                 335     


Arg Glu Phe Gly Gly Tyr Lys Leu Ser Leu His Ser Gly Ser Asp Lys 
            340                 345                 350         


Phe Ser Ile Tyr Lys Val Phe Ser Glu Ile Thr Glu Gly Glu Phe His 
        355                 360                 365             


Ile Lys Thr Ser Gly Thr Ser Trp Leu Gln Ala Val Asn Leu Ile Phe 
    370                 375                 380                 


Glu Lys Asp Lys Glu Leu Phe Lys Glu Leu Tyr Gln Ile Ala Leu Tyr 
385                 390                 395                 400 


Asn Leu Glu Glu Ser Lys Lys Ala Tyr Lys Val Leu Ile Asp Lys Lys 
                405                 410                 415     


Asp Phe Pro Glu Asn Ile Asn Leu Glu Asp Ser Gln Ile Val Ser Lys 
            420                 425                 430         


Pro Glu Ile Lys Gln Leu Phe His Ile Ser Tyr Gly Val Leu Leu Glu 
        435                 440                 445             


Glu Arg Lys Lys Gln Ile Phe Glu Val Leu Asn Lys Tyr Glu Glu Glu 
    450                 455                 460                 


His Tyr Glu Phe Val Arg Lys Asn Ile Glu Asn His Phe Lys Glu Ile 
465                 470                 475                 480 


Phe Ser Lys 
            


<210>  363
<211>  490
<212>  PRT
<213>  Caldanaerobacter subterraneus

<400>  363

Met Phe Glu Arg Lys Ile Glu Met Ile Asn Lys Val Ala Glu Tyr Leu 
1               5                   10                  15      


Ser Arg Glu Gly Phe Tyr Phe Tyr Glu Lys Ser Phe Arg Lys Phe Ser 
            20                  25                  30          


Glu Asp Ile Tyr Ile Phe Val Val Lys Lys Ala Asn Glu Lys Ser Ile 
        35                  40                  45              


Gly Leu Leu Thr Gln Gly Asp Phe Thr Leu Ser Ser Pro Tyr Phe Thr 
    50                  55                  60                  


Glu Arg Lys Tyr Leu Lys Glu Ile Gly Tyr Tyr Leu Asn Leu Tyr Pro 
65                  70                  75                  80  


Leu Thr Tyr Glu Asn Phe Val Ile Leu Lys Asp Lys Phe Ser Ile Ala 
                85                  90                  95      


Pro Ser Pro Cys Asn Lys Lys Val Ser Phe Gly Met Gly Asp Arg Leu 
            100                 105                 110         


Gly Leu Val Thr Ala Ala His Ile Arg Ala Val Glu Asn Tyr Asp Val 
        115                 120                 125             


Phe Pro Val Leu Ala Gln Gln Ser Pro Arg Glu Leu Met Lys Thr His 
    130                 135                 140                 


Arg Ser Phe Lys Glu Ala Ile Leu Lys Ala Ile Leu Gly Val Leu Glu 
145                 150                 155                 160 


Glu Gly Tyr Thr Gly Lys Phe Gly Ala Asp Ala Asp His Ile Lys Asp 
                165                 170                 175     


Glu Asn Tyr Leu Met Glu Ala Ile Asp Ala Gly Tyr Thr Met Tyr Thr 
            180                 185                 190         


Leu Asp Leu Ser Asp Met Leu Val Lys Leu Ser Asp Tyr Thr Glu Ser 
        195                 200                 205             


Gln Leu Lys Glu Lys Ala Glu Lys Leu Asn Ile Thr Ser Lys Arg Ile 
    210                 215                 220                 


Ile Glu Lys Phe Lys Gly Lys Lys Phe Val Met Pro Thr Glu Glu Ala 
225                 230                 235                 240 


Phe Thr Val Ser Glu Glu Glu Leu Tyr Lys Ser Ala Leu Thr Tyr Glu 
                245                 250                 255     


Lys Ala Met Asp Phe Val Glu Lys Val Tyr Gly Ile Leu Lys Asp Lys 
            260                 265                 270         


Val Lys Asn Phe Asp Leu Glu Ile Ser Ile Asp Glu Gly Asp Lys Asp 
        275                 280                 285             


Thr Thr Val Glu Asp His Ile Phe Val Ala Glu Tyr Leu His Glu Lys 
    290                 295                 300                 


Gly Ile Asp Phe Trp Ser Leu Ala Pro Lys Phe Pro Gly Glu Phe Gln 
305                 310                 315                 320 


Lys Ala Ile Asp Tyr Ile Gly Asp Val Asp Lys Phe Ala Val Glu Leu 
                325                 330                 335     


Lys Lys His Gln Phe Leu Ser Arg Glu Phe Gly Gly Tyr Lys Leu Ser 
            340                 345                 350         


Leu His Ser Gly Ser Asp Lys Phe Ser Ile Tyr Lys Val Phe Ser Glu 
        355                 360                 365             


Ile Thr Glu Gly Glu Phe His Ile Lys Thr Ser Gly Thr Ser Trp Leu 
    370                 375                 380                 


Gln Ala Val Asn Leu Ile Phe Glu Lys Asp Lys Lys Leu Phe Lys Glu 
385                 390                 395                 400 


Leu Tyr Gln Ile Ala Leu Tyr Asn Leu Glu Glu Ser Lys Lys Ala Tyr 
                405                 410                 415     


Lys Val Leu Ile Asp Lys Lys Asp Phe Pro Glu Asn Ile Asn Leu Glu 
            420                 425                 430         


Asp Ser Gln Ile Val Ser Lys Pro Glu Ile Lys Gln Leu Phe His Ile 
        435                 440                 445             


Ser Tyr Gly Val Leu Leu Glu Glu Arg Lys Lys Gln Ile Phe Glu Val 
    450                 455                 460                 


Leu Asn Lys Tyr Glu Glu Glu His Tyr Glu Phe Val Arg Lys Asn Val 
465                 470                 475                 480 


Glu Asn His Phe Lys Glu Ile Phe Ser Lys 
                485                 490 


<210>  364
<211>  483
<212>  PRT
<213>  Caldicoprobacter faecalis

<400>  364

Met Gly Met Met Asp Lys Asp Val Leu Asn Gln Leu Ser Ser Leu Leu 
1               5                   10                  15      


Ser Arg His Ser Phe Val Leu Tyr Pro Asn Ser Val Arg Asn Leu Ala 
            20                  25                  30          


Glu Asp Ile Tyr Val Phe Val Ala Lys Gly Asn Ala Asp Lys Lys Val 
        35                  40                  45              


Gly Ile Leu Ser Lys Gly Lys Ala Leu Gly Phe Lys Ala Pro Phe Phe 
    50                  55                  60                  


Ala Glu Asp Ile Lys Val Glu Ala Thr Gly Phe Ser Phe Asn Leu Tyr 
65                  70                  75                  80  


Pro Leu Ser Phe Glu Asn Tyr Leu Ile Leu Arg Asp Glu Phe Gly Ile 
                85                  90                  95      


Ala Leu Val Pro Cys Lys Asn Lys Ala Ser Phe Gly Thr Gly Asp Arg 
            100                 105                 110         


Leu Gly Leu Ala Thr Pro Ala His Leu Asp Ala Phe Lys Ser Tyr Asn 
        115                 120                 125             


Met Phe Pro Val Leu Ala Gln Gln Ser Pro Arg Glu Leu Glu Lys Thr 
    130                 135                 140                 


His Arg Asp Phe Arg Asp Val Leu Leu Lys Ala Val Leu Gly Val Leu 
145                 150                 155                 160 


Glu Ala Gly Tyr Thr Gly Glu Phe Gly Ala Asp Ala Asp His Ile Lys 
                165                 170                 175     


Asp Glu Arg Tyr Leu Leu Glu Ala Ala Asp Ala Gly Tyr Thr Met Tyr 
            180                 185                 190         


Thr Leu Asp Val Ser Glu Met Leu Val Lys Gly Asp Val Ser Pro Asp 
        195                 200                 205             


Lys Ala Asp His Leu Ser Gln His Ser Arg Asp Ile Ile Lys Asp Phe 
    210                 215                 220                 


Ser Gly Lys Arg Ile Ser Phe Glu Gly Gly Glu Tyr Thr Val Lys Glu 
225                 230                 235                 240 


Glu Glu Leu Tyr Arg Ser Ala Val Ile Tyr Glu Lys Ala Met Asn Phe 
                245                 250                 255     


Val Glu Arg Val His Gly Leu Leu Lys Glu Arg Leu Lys Asp Phe Asp 
            260                 265                 270         


Leu Glu Val Ser Ile Asp Glu Gly Asp Arg Asp Thr Thr Val Glu Asp 
        275                 280                 285             


His Ile Phe Val Ala Glu Tyr Leu His Arg Arg Gly Ile Asp Phe Trp 
    290                 295                 300                 


Ser Leu Ala Pro Lys Phe Pro Gly Glu Phe Glu Lys Ala Val Asp Tyr 
305                 310                 315                 320 


Arg Gly Asp Ile Asp Lys Phe Thr Val Glu Leu Asn Lys His Cys Ala 
                325                 330                 335     


Val Ala Arg Met Leu Gly Gly Tyr Arg Leu Ser Leu His Ser Gly Ser 
            340                 345                 350         


Asp Lys Phe Ser Val Tyr Arg Ile Phe Asn Asp Ala Thr Gln His Asn 
        355                 360                 365             


Phe His Ile Lys Thr Ser Gly Thr Ser Trp Leu Gln Ala Leu Asn Val 
    370                 375                 380                 


Ile His Glu Lys Asp Arg Gln Leu Phe Lys Glu Leu Tyr Asn Ile Ala 
385                 390                 395                 400 


Leu Asp Asn Leu Glu Glu Ser Lys Lys Ala Tyr Lys Ile Ser Ile Tyr 
                405                 410                 415     


Arg Gln Asp Phe Glu Glu Gly Leu Asp Leu Asp Asn Leu His Val Leu 
            420                 425                 430         


Gln Asn Pro Lys Val Lys Gln Leu Leu His Ile Ser Tyr Gly Val Leu 
        435                 440                 445             


Leu Asp Glu Lys Arg Gln Glu Ile Tyr Glu Val Leu Asn Gln His Glu 
    450                 455                 460                 


Ala Glu His Tyr Arg Tyr Val Ser Asp Asn Ile Lys Lys His Leu Glu 
465                 470                 475                 480 


Leu Leu Lys 
            


<210>  365
<211>  483
<212>  PRT
<213>  Thermoanaerobacter uzonensis

<400>  365

Met Lys Glu Glu Leu Ser Asn Tyr Leu Leu Lys Asn Ser Phe Leu Leu 
1               5                   10                  15      


Tyr Pro Asp Ser Phe Arg Arg Leu Lys Glu Asp Val Tyr Ile Phe Val 
            20                  25                  30          


Ala Lys Lys Asp Ser Asp Lys Lys Ile Gly Phe Leu Thr Asn Gly Asn 
        35                  40                  45              


Phe Lys Leu Ser Ser Pro His Phe Leu Glu Asp Lys Tyr Val Glu Glu 
    50                  55                  60                  


Leu Gly Phe Tyr Leu Asn Leu Tyr Pro Leu Thr Tyr Glu Asn Tyr Leu 
65                  70                  75                  80  


Ile Leu Lys Asp Asn Phe Gly Ile Ser Pro Val Thr Cys Lys Glu Lys 
                85                  90                  95      


Thr Ser Phe Gly Thr Gly Asp Arg Leu Gly Leu Val Thr Pro Ala His 
            100                 105                 110         


Ile Lys Val Leu Lys Asn Tyr Asp Ile Phe Pro Val Leu Ala Gln Gln 
        115                 120                 125             


Ser Pro Arg Glu Leu Val Lys Thr Asn Arg Asp Phe Lys Asp Val Leu 
    130                 135                 140                 


Leu Lys Ala Ile Leu Gly Val Leu Glu Ala Gly Tyr Ala Gly Gly Phe 
145                 150                 155                 160 


Gly Ala Asp Ala Asp His Ile Lys Asp Glu Lys Tyr Leu Met Glu Ala 
                165                 170                 175     


Ile Asp Ala Gly Tyr Thr Met Tyr Thr Leu Asp Leu Ser Asp Leu Leu 
            180                 185                 190         


Val Lys Ile Ser Asp Met Pro Glu Ser Gln Leu Lys Glu Lys Ala Gln 
        195                 200                 205             


Ser Leu Ser Ser Gln Ser Arg Glu Ile Ile Asp Arg Tyr Lys Gly Lys 
    210                 215                 220                 


Lys Phe Ser Ile Ser Thr Asp Glu Asp Phe Val Val Ser Glu Asp Glu 
225                 230                 235                 240 


Leu Tyr Lys Ser Ala Leu Thr Tyr Glu Lys Ala Met Lys Phe Val Glu 
                245                 250                 255     


Lys Val Tyr Gly Ile Leu Lys Asp Arg Leu Gln His Phe Asp Leu Glu 
            260                 265                 270         


Ile Ser Ile Asp Glu Gly Glu Lys Asp Thr Thr Val Glu Asp His Ile 
        275                 280                 285             


Phe Val Val Glu Tyr Leu His Arg Lys Gly Ile Asp Phe Trp Ser Leu 
    290                 295                 300                 


Ala Pro Lys Phe Pro Gly Glu Phe Gln Lys Ala Ile Asp Tyr Lys Gly 
305                 310                 315                 320 


Asp Ile Lys Lys Phe Thr Ser Glu Leu Lys Lys His Tyr Phe Leu Thr 
                325                 330                 335     


Lys Glu Leu Gly Gly Tyr Lys Leu Ser Leu His Ser Gly Ser Asp Lys 
            340                 345                 350         


Phe Ser Ile Tyr Lys Ile Phe Asn Glu Ile Thr Glu Gly Asn Phe His 
        355                 360                 365             


Ile Lys Thr Ser Gly Thr Ser Trp Leu Gln Ala Ile Ser Leu Ile Phe 
    370                 375                 380                 


Glu Lys Asp Lys Asp Leu Phe Asn Asp Leu Tyr Lys Ile Ala Leu Asp 
385                 390                 395                 400 


Asn Leu Glu Glu Ser Lys Lys Ala Tyr Lys Val Leu Ile Asp Arg Asp 
                405                 410                 415     


Asp Phe Pro Gln Thr Ile Gln Thr Glu Asp Ser Gln Ile Leu Ser Lys 
            420                 425                 430         


Pro Glu Ile Lys Gln Leu Phe His Ile Ser Tyr Gly Val Leu Leu Asp 
        435                 440                 445             


Glu Arg Arg Lys Glu Ile Tyr Glu Val Leu Asn Lys Tyr Glu Glu Glu 
    450                 455                 460                 


His Tyr Glu Phe Val Ser Lys Asn Ile Lys Asn His Leu Lys Glu Ile 
465                 470                 475                 480 


Phe Asn Ile 
            


<210>  366
<211>  533
<212>  PRT
<213>  Lactobacillus ingluviei

<400>  366

Met Asp Leu Asn Gly Leu Leu Lys Asp Val Glu Glu Ile Leu Ala Lys 
1               5                   10                  15      


Val Asp Ala Gly Glu Lys Val Glu Ser Leu Ser Asp Ala Gly Val Tyr 
            20                  25                  30          


Val Pro Ser Val Gln Val Asp Arg Arg Asn Val Tyr Phe Ile Tyr His 
        35                  40                  45              


Thr Lys Asp Glu Lys Asp His Thr Val Lys Thr Leu Val Val Tyr Glu 
    50                  55                  60                  


Glu Asn Pro Thr Ile Gly Asp Phe Asp Ala Leu Glu Thr Leu Lys Gly 
65                  70                  75                  80  


Glu Asn Ser Thr Leu Ile Thr Ala Ala Leu Thr Asp His Asn Asn Gln 
                85                  90                  95      


Ala Leu Ala Lys Arg Phe Pro Trp Ile Lys Pro Thr Ser Arg Arg Asn 
            100                 105                 110         


Tyr Lys Tyr Thr Phe Gly Leu Gly Asp Arg Leu Gly Asn Ala Ser Asn 
        115                 120                 125             


Ala His Leu Arg Leu Phe Lys Gly Thr Gly Ile Met Pro Val Leu Ala 
    130                 135                 140                 


Gln Gln Ser Ile Arg Glu Leu Thr Leu Met His Arg Thr Asn Thr Asp 
145                 150                 155                 160 


Val Leu Leu Ser Ala Ser Trp Ala Val Phe Glu Glu Gly Phe Thr Phe 
                165                 170                 175     


Gly Trp Gly Ala Asp Gly Asp His Val Lys Thr Glu Tyr Glu Val Asp 
            180                 185                 190         


Tyr Ala Val Lys Val Gly Cys Ser Met Ile Thr Leu Asp Cys Thr Asp 
        195                 200                 205             


Val Ile Asn Asn Asp Ala Val Thr Met Ser Asp Glu Glu Leu Asp Lys 
    210                 215                 220                 


Thr Phe Asn Ala Leu Asp Asp Asp Gln Lys Lys Tyr Phe Asn Asp Thr 
225                 230                 235                 240 


Tyr Leu Asp Lys Thr Phe Asp Leu Gly Asn Gly Asn Ser Val His Phe 
                245                 250                 255     


Thr Lys His Asp Val Glu Glu Ser Val Leu Thr Phe Tyr Gly Ala Ile 
            260                 265                 270         


Leu Phe Ala Ala Asp Ile Tyr Lys Lys Phe Val Val Pro Tyr Asn Leu 
        275                 280                 285             


Asp Phe Glu Ile Ser Met Asp Glu Thr Pro Tyr Gln Thr Thr Asn Pro 
    290                 295                 300                 


Asn His Phe Phe Phe Gly Asn Glu Leu His Lys Arg Gly Ile Val Pro 
305                 310                 315                 320 


Thr Thr Met Ala Pro Arg Phe Tyr Gly Glu Phe Gln Lys Ala Ile Asp 
                325                 330                 335     


Tyr Ile Gly Asp Lys Asp Arg Phe Glu Arg Glu Phe Val Leu His Glu 
            340                 345                 350         


Ala Ile Ala Glu Tyr Phe Gly Tyr Lys Leu Ser Ile His Ser Gly Ser 
        355                 360                 365             


Asp Lys Leu Ser Val Tyr Glu Ile Ile Gly Arg Val Ala Lys Asn Gly 
    370                 375                 380                 


Trp His Val Lys Thr Ala Gly Thr Asn Trp Leu Glu Ala Leu Arg Val 
385                 390                 395                 400 


Ile Ala His Lys Asp Pro Glu Phe Met Val Glu Leu Tyr Lys Tyr Ala 
                405                 410                 415     


Tyr Glu His Leu Asp Asp Val Lys Asp Phe Tyr Val Phe Asn Ala Gln 
            420                 425                 430         


Thr Asp Gly Lys Ala Pro Lys Pro Glu Asn Val Thr Val Asp Asn Val 
        435                 440                 445             


Val Asp Val Leu Ser Asp Asp Asp Gly Arg Gln Val Leu His Thr Met 
    450                 455                 460                 


Tyr Gly Ser Leu Met Asn Leu Lys His Asn Tyr His Tyr Val Phe Arg 
465                 470                 475                 480 


Asp Lys Phe Trp Asp Ile Leu Leu Lys Asn Gln Asp Leu Tyr Asp Lys 
                485                 490                 495     


Tyr Leu Asn Ile His Ile Ala Glu His Ile Asp Leu Leu Gln Gly Lys 
            500                 505                 510         


Tyr Lys Thr Lys Glu Glu Ala Leu Ala Ala Leu Glu Pro Lys Thr Asp 
        515                 520                 525             


Ile Ser Lys Glu Tyr 
    530             


<210>  367
<211>  390
<212>  PRT
<213>  Petrotoga mexicana

<400>  367

Met Phe Thr Ile Leu Pro Lys Lys Gly Ile Ser Leu Gly Leu Gly Asp 
1               5                   10                  15      


Arg Ile Gly Ile Ala Thr Thr Gly His Ile Lys Val Ala Lys Lys Tyr 
            20                  25                  30          


Asn Phe Phe Pro Val Phe Ala Gln Gln Ser Ile Arg Glu Leu Asn Phe 
        35                  40                  45              


Thr Gly Arg Thr Phe Thr Asp Val Arg Lys Asp Val Leu Asn Ala Leu 
    50                  55                  60                  


Ile Glu Glu Asn Tyr Val Gly Asn Ser Gly Phe Asp Gly Asp His Leu 
65                  70                  75                  80  


Lys Ser Asp Glu Glu Ile Gln Tyr Ala Leu Asp Ser Gly Ile Thr Met 
                85                  90                  95      


Leu Thr Leu Asp Cys Ser Glu His Met Asn Lys Asp Ser Ser Ile Lys 
            100                 105                 110         


Asp Gln Ile Phe Glu Gln Phe Tyr Asn Lys Ser Phe Phe Val Asn Asp 
        115                 120                 125             


Met Pro Ile Glu Tyr Ser Asp Lys Asn Glu Leu Asn Glu Ile Val Ser 
    130                 135                 140                 


Ile Tyr Ala Ser Val Ile Glu Arg Val Ile Asp Val Trp Asn Lys Phe 
145                 150                 155                 160 


Pro Lys Val Asn Lys Lys Glu Val Ser Phe Glu Val Ser Val Asp Glu 
                165                 170                 175     


Thr Asp Val Pro Thr Asp Glu Lys Thr His Phe Leu Ile Ser Lys Tyr 
            180                 185                 190         


Ile Asn Asp Glu Gly Val Lys Ile Asp Thr Leu Ala Pro Arg Phe Pro 
        195                 200                 205             


Gly Glu Phe Gln Lys Gly Ile Asp Tyr Ile Gly Asn Val Gln Glu Phe 
    210                 215                 220                 


Lys Lys Ser Leu Ile Lys Gln Glu Lys Ile Ala Lys Tyr Phe Gly Tyr 
225                 230                 235                 240 


Arg Leu Ser Ile His Ser Gly Ser Asp Lys Phe Ser Ile Tyr Pro Ile 
                245                 250                 255     


Ile Gly Glu Val Thr Gln Gly Asn Tyr His Leu Lys Thr Ser Gly Thr 
            260                 265                 270         


Ser Phe Leu Glu Ala Ile Lys Val Val Ala Gln Lys Asp Pro Glu Phe 
        275                 280                 285             


Phe Lys Lys Ile Trp Gln Thr Cys Leu Asp Lys Arg Glu Glu Met Asp 
    290                 295                 300                 


Lys Tyr Tyr His Leu Ser Cys Asn Pro Phe Ser Val Pro Lys Asp Leu 
305                 310                 315                 320 


Ser Pro Thr Glu Tyr Leu Lys Asn Pro Asp Ala Arg Gln Thr Leu His 
                325                 330                 335     


Val Ser Tyr Met Phe Val Leu Asn Pro Gln Tyr Asp Phe Arg Glu Lys 
            340                 345                 350         


Phe Phe Glu Ile Leu Thr Lys Tyr Gln Asn Glu Tyr His Glu Asn Val 
        355                 360                 365             


Ala Asn His Ile Glu Lys His Val Lys Glu Leu Lys Ile Glu Glu Thr 
    370                 375                 380                 


Ile His Lys Gln Lys Lys 
385                 390 


<210>  368
<211>  386
<212>  PRT
<213>  Defluviitoga tunisiensis

<400>  368

Met Phe Ser Lys Leu Pro Lys Gln Gly Ile Ser Leu Gly Leu Gly Asp 
1               5                   10                  15      


Arg Val Gly Leu Ala Thr Pro Gly His Ile Lys Val Ala Lys Arg His 
            20                  25                  30          


Glu Phe Phe Pro Val Phe Ala Gln Gln Ser Ile Arg Glu Leu Asn Phe 
        35                  40                  45              


Thr Gly Arg Thr Phe His Asp Val Lys Lys Asp Val Glu Asn Ala Val 
    50                  55                  60                  


Ile Lys Glu Asn Tyr Glu Gly Lys Ser Gly Phe Asp Gly Asp His Leu 
65                  70                  75                  80  


Lys Thr Asp Glu Glu Ile Lys Met Ala Ile Asp Ser Gly Ile Thr Met 
                85                  90                  95      


Leu Thr Leu Asp Cys Ser Glu Tyr Met Gly Val Val Ser Lys Ile Lys 
            100                 105                 110         


Glu Lys Ile Tyr Lys Gly Phe Tyr Gly Lys Thr Phe Lys Val Lys Asp 
        115                 120                 125             


Leu Asp Leu Glu Tyr Ser Gln Glu Glu Leu Glu Lys Ile Leu Ser Ile 
    130                 135                 140                 


Tyr Ser Gly Val Ile Glu Arg Ile Ile Tyr Ile Trp Asn Asn Phe Pro 
145                 150                 155                 160 


Lys Val Lys Asn Lys Asp Val Ser Phe Glu Val Ser Ile Asp Glu Thr 
                165                 170                 175     


Asn Ile Pro Thr Asp Glu Lys Thr His Phe Leu Leu Ser Lys Tyr Leu 
            180                 185                 190         


Tyr Asp Glu Gly Ile Thr Ile Asp Thr Leu Ala Pro Arg Phe Pro Gly 
        195                 200                 205             


Glu Phe Gln Lys Gly Ile Asp Tyr Ile Gly Asn Ile Lys Glu Phe Lys 
    210                 215                 220                 


Asn Ser Leu Met Lys His His Lys Ile Ala Ser Tyr Phe Gly Tyr Arg 
225                 230                 235                 240 


Leu Ser Ile His Ser Gly Ser Asp Lys Phe Ser Ile Tyr Pro Tyr Val 
                245                 250                 255     


Ser Gln Ile Thr Gln Gly Asn Tyr His Leu Lys Thr Ser Gly Thr Ser 
            260                 265                 270         


Tyr Leu Gln Ala Leu Lys Ile Ile Ala Gln Lys Ala Pro Asp Phe Phe 
        275                 280                 285             


Lys Glu Ile Trp Lys Thr Cys Leu Asp Lys Arg Thr Glu Met Asp Lys 
    290                 295                 300                 


Tyr Tyr His Leu Ser Cys Asp Pro Phe Ser Val Pro Lys Asp Leu Lys 
305                 310                 315                 320 


Pro Ile Glu Tyr Leu Asn Asn Pro Asp Ala Arg Gln Thr Leu His Val 
                325                 330                 335     


Ser Tyr Met Phe Val Leu Asn Pro Lys Tyr Asp Phe Arg Asn Arg Phe 
            340                 345                 350         


Phe Glu Ile Leu Thr Lys Tyr Glu Asn Glu Tyr His Ile Glu Val Ala 
        355                 360                 365             


Glu His Ile Lys Arg His Val Lys Glu Leu Lys Ile Pro Glu Lys Ile 
    370                 375                 380                 


Gln Asn 
385     


<210>  369
<211>  385
<212>  PRT
<213>  Petrotoga miotherma

<400>  369

Met Phe Thr Ile Leu Pro Lys Lys Gly Ile Ser Leu Gly Leu Gly Asp 
1               5                   10                  15      


Arg Ile Gly Ile Ala Thr Pro Gly His Ile Lys Val Ala Lys Lys Tyr 
            20                  25                  30          


Asn Phe Phe Pro Val Phe Ala Gln Gln Ser Ile Arg Glu Leu Asn Phe 
        35                  40                  45              


Thr Gly Arg Thr Phe Thr Asp Val Arg Lys Asp Val Leu Asn Ala Leu 
    50                  55                  60                  


Val Glu Glu Asn Tyr Val Gly Asn Ser Gly Phe Asp Gly Asp His Leu 
65                  70                  75                  80  


Lys Ser Asp Glu Glu Ile Gln Tyr Ala Leu Asp Ser Gly Ile Thr Met 
                85                  90                  95      


Leu Thr Leu Asp Cys Ser Glu His Met Asn Lys Asp Ser Ser Ile Lys 
            100                 105                 110         


Asp Gln Ile Phe Glu Gln Phe Tyr Asn Lys Ser Phe Phe Val Asn Asp 
        115                 120                 125             


Met Pro Ile Glu Tyr Ser Asp Lys Asn Glu Leu Asn Lys Ile Val Ser 
    130                 135                 140                 


Ile Tyr Ala Ser Val Ile Glu Arg Val Ile Asp Val Trp Asn Lys Phe 
145                 150                 155                 160 


Pro Lys Val Asn Lys Lys Glu Val Thr Phe Glu Val Ser Val Asp Glu 
                165                 170                 175     


Thr Asp Val Pro Thr Asp Glu Lys Thr His Phe Leu Ile Ser Lys Tyr 
            180                 185                 190         


Ile Tyr Asp Glu Gly Val Lys Ile Asp Thr Leu Ala Pro Arg Phe Pro 
        195                 200                 205             


Gly Glu Phe Gln Lys Ala Ile Asp Tyr Ile Gly Asn Ile Gln Glu Phe 
    210                 215                 220                 


Lys Lys Ser Leu Ile Lys Gln Asn Lys Ile Ala Lys Tyr Phe Gly Tyr 
225                 230                 235                 240 


Arg Leu Ser Ile His Ser Gly Ser Asp Lys Phe Ser Ile Tyr Pro Ile 
                245                 250                 255     


Ile Gly Glu Val Thr Gln Gly Asn Tyr His Leu Lys Thr Ser Gly Thr 
            260                 265                 270         


Ser Tyr Leu Glu Ala Ile Lys Val Val Ala Gln Lys Asp Pro Glu Phe 
        275                 280                 285             


Phe Lys Lys Ile Trp Gln Thr Cys Leu Asp Lys Arg Glu Glu Met Asp 
    290                 295                 300                 


Lys Tyr Tyr His Leu Ser Cys Asp Pro Phe Ser Val Pro Lys Asp Leu 
305                 310                 315                 320 


Ser Pro Thr Glu Tyr Leu Lys Asn Ile Asp Ala Arg Gln Thr Leu His 
                325                 330                 335     


Val Ser Tyr Met Phe Val Leu Asn Pro Gln Tyr Asp Phe Arg Glu Lys 
            340                 345                 350         


Phe Phe Glu Ile Leu Thr Lys Tyr Gln Asn Glu Tyr Tyr Glu Asn Val 
        355                 360                 365             


Ala Asn His Ile Glu Lys His Val Lys Glu Leu Lys Ile Glu Glu Thr 
    370                 375                 380                 


Lys 
385 


<210>  370
<211>  385
<212>  PRT
<213>  Petrotoga olearia

<400>  370

Met Phe Thr Ile Leu Pro Lys Lys Gly Ile Ser Ile Gly Leu Gly Asp 
1               5                   10                  15      


Arg Ile Gly Ile Ala Thr Pro Gly His Ile Lys Val Ala Lys Lys Tyr 
            20                  25                  30          


Asn Phe Phe Pro Val Phe Ala Gln Gln Ser Ile Arg Glu Leu Asn Phe 
        35                  40                  45              


Thr Gly Arg Thr Phe Arg Asp Val Arg Lys Asp Val Leu Asn Ala Leu 
    50                  55                  60                  


Val Glu Glu Asn Tyr Val Gly Asn Ser Gly Phe Asp Gly Asp His Leu 
65                  70                  75                  80  


Lys Ser Asp Glu Glu Ile Gln Tyr Ala Leu Asp Ser Gly Ile Thr Met 
                85                  90                  95      


Leu Thr Leu Asp Cys Ser Glu His Met Asn Lys Asp Ser Ser Val Lys 
            100                 105                 110         


Glu Ser Ile Phe Asp Gln Phe Tyr Asn Lys Ser Phe Phe Val Asn Asp 
        115                 120                 125             


Met Pro Ile Glu Tyr Ser Asp Lys Asn Glu Leu Asn Lys Ile Val Ser 
    130                 135                 140                 


Ile Tyr Gly Gly Val Ile Glu Arg Val Ile Asp Val Trp Asn Lys Phe 
145                 150                 155                 160 


Pro Lys Val Asn Lys Lys Glu Val Ser Phe Glu Val Ser Val Asp Glu 
                165                 170                 175     


Thr Asp Val Pro Thr Asp Glu Lys Thr His Phe Leu Ile Ser Lys Tyr 
            180                 185                 190         


Ile Tyr Asp Glu Gly Val Lys Ile Asp Thr Leu Ala Pro Arg Phe Pro 
        195                 200                 205             


Gly Glu Phe Gln Lys Gly Ile Asp Tyr Ile Gly Asn Ile Gln Glu Phe 
    210                 215                 220                 


Lys Lys Ser Leu Ile Lys Gln Asp Lys Ile Ala Lys Tyr Phe Gly Tyr 
225                 230                 235                 240 


Arg Leu Ser Ile His Ser Gly Ser Asp Lys Phe Ser Ile Tyr Pro Ile 
                245                 250                 255     


Ile Gly Glu Val Thr Gln Gly Asn Tyr His Leu Lys Thr Ser Gly Thr 
            260                 265                 270         


Ser Tyr Leu Glu Ala Ile Lys Val Ile Ala Gln Lys Asp Pro Glu Phe 
        275                 280                 285             


Phe Lys Lys Ile Trp Gln Thr Cys Leu Asp Lys Arg Glu Glu Met Asp 
    290                 295                 300                 


Lys Tyr Tyr His Leu Ser Cys Asp Pro Phe Ser Val Pro Lys Asp Leu 
305                 310                 315                 320 


Ser Pro Thr Glu Tyr Leu Gln Asn Pro Asp Ala Arg Gln Thr Leu His 
                325                 330                 335     


Val Ser Tyr Met Phe Val Leu Asn Pro Gln Tyr Asp Phe Arg Lys Lys 
            340                 345                 350         


Phe Phe Glu Ile Leu Thr Lys Tyr Gln Asn Glu Tyr His Glu Asn Val 
        355                 360                 365             


Ala His His Ile Glu Lys His Val Lys Glu Leu Lys Val Glu Glu Thr 
    370                 375                 380                 


Lys 
385 


<210>  371
<211>  418
<212>  PRT
<213>  Thermophagus xiamenensis

<400>  371

Met Lys Lys Leu Ala Lys Tyr Ser Phe Gly Met Gly Asp Arg Phe Ala 
1               5                   10                  15      


His Gln Ala Ser Trp Gln Leu Lys Ala Ile Thr Glu Ile Glu Lys Gln 
            20                  25                  30          


Gly Ile Glu Val Thr Pro Val Trp Asn Lys Ser Asn Arg Glu His Thr 
        35                  40                  45              


Thr Ile Gly Ser Lys Pro Glu Asp Asn Arg Asp Ala Ala Gln Lys Ala 
    50                  55                  60                  


Ile Gln Lys Ala Gly Trp Ser Lys Pro Trp Tyr Ile Asp Ala Asp His 
65                  70                  75                  80  


Ile Asn Leu Asp Thr Val Asp Asn Phe Leu Glu Ser Ser Asp Phe Phe 
                85                  90                  95      


Thr Ile Asp Val Ala Ser Tyr Ile Gly Lys Lys Gly Asp Ser Lys Glu 
            100                 105                 110         


Glu Glu Thr Phe Ile Ser Lys Met Lys Pro Leu Ile Gly Asn Leu Asn 
        115                 120                 125             


Ile Pro Gly Val Asn Ser Pro Phe Lys Ile Thr Glu Gln Gln Leu Arg 
    130                 135                 140                 


Asn Ile Ala Gly Gln Tyr Leu His Ala Ala Phe Met Ala Gly Glu Thr 
145                 150                 155                 160 


Tyr Lys Tyr Ile Glu Ser Val Lys Gly Lys Gly Asn Phe Ile Thr Glu 
                165                 170                 175     


Val Ser Met Asp Glu Val Pro Glu Pro Gln Thr Pro Val Glu Leu Phe 
            180                 185                 190         


Phe Ile Leu Ala Met Leu Ala His Tyr Gly Val Pro Ala Gln Thr Ile 
        195                 200                 205             


Ala Pro Lys Phe Thr Gly Arg Phe Asn Lys Gly Val Asp Tyr Val Gly 
    210                 215                 220                 


Asp Ile Glu Thr Phe Arg Lys Glu Tyr Glu Ala Asn Leu Met Val Ile 
225                 230                 235                 240 


Asp Tyr Ala Ile Gln Lys Phe Gly Phe Pro Pro Glu Leu Lys Leu Ser 
                245                 250                 255     


Ile His Ser Gly Ser Asp Lys Phe Ser Ile Tyr Pro Val Ile Lys Glu 
            260                 265                 270         


Leu Ser Gln Lys His Asn Lys Gly Phe His Leu Lys Thr Ala Gly Thr 
        275                 280                 285             


Thr Trp Leu Glu Glu Val Ile Gly Leu Ala Met Ala Gly Gly Glu Ala 
    290                 295                 300                 


Leu Leu Phe Val Lys Asn Ile Tyr Ser Arg Ala Leu Asp Asn Ile Glu 
305                 310                 315                 320 


Lys Leu Cys Ala Pro Tyr Ala Asp Val Ile Asp Ile Asn Thr Asp Asn 
                325                 330                 335     


Leu Pro Lys Leu Ser Glu Val Asn Asn Trp Thr Gly Glu Glu Phe Ala 
            340                 345                 350         


Asn Ala Leu Arg His Val Pro Asp His Pro Met Tyr Asn Pro Asp Leu 
        355                 360                 365             


Arg Gln Leu Ile His Val Ala Tyr Lys Leu Ala Ala Glu Asn Ile Asn 
    370                 375                 380                 


Gln Phe Asn Ser Phe Leu Glu Gln His Ser Glu Ile Val Gly Lys Cys 
385                 390                 395                 400 


Val Phe Glu Asn Leu Tyr Lys Arg His Ala Glu Arg Leu Phe Val Phe 
                405                 410                 415     


Ser Asn 
        


<210>  372
<211>  416
<212>  PRT
<213>  Treponema caldarium

<400>  372

Met Lys Gln Leu Glu Arg Phe Ser Met Gly Ile Gly Asp Arg Phe Gly 
1               5                   10                  15      


His Gln Gly Lys Ala Gln Leu Glu Ala Leu Ala Glu Ala Lys His Leu 
            20                  25                  30          


Gly Cys Thr Ile Ile Pro Val Trp Asn Lys Ser Tyr Arg Glu His Ser 
        35                  40                  45              


Ile Ile His Thr Glu Pro Gly Gln Val Arg Lys Glu Ala Asp Trp Ala 
    50                  55                  60                  


Val Ala Ala Leu Gly Trp Gln Asp Pro Tyr His Val Asp Ala Asp His 
65                  70                  75                  80  


Ile Ser Met Lys Thr Val Asp Leu Phe Leu Asp Ser Ser Asp Phe Phe 
                85                  90                  95      


Thr Leu Asp Val Ala Asp Tyr Thr Gly Lys Ala Ala Asp Glu Ala Ser 
            100                 105                 110         


Ile Ala Arg Phe Val Ala Lys His Gln His Cys Ile Gly Lys Leu Gln 
        115                 120                 125             


Ile Pro Gly Ile Glu Gln Pro Ile Thr Ile Thr Glu Thr Thr Leu Thr 
    130                 135                 140                 


Ser Val Ala Arg Lys Tyr Leu Leu Ala Ile Gln Glu Ala Gly Lys Leu 
145                 150                 155                 160 


Tyr Arg His Ile Ala Asn Lys Lys Gly Pro Glu Asn Phe Ile Thr Glu 
                165                 170                 175     


Val Ser Ile Asp Glu Thr Asp Gln Pro Gln Gly Pro Glu Asp Leu Leu 
            180                 185                 190         


Phe Ile Leu Ala Met Ile Ala Asp Glu Gly Ile Pro Ala Gln Thr Ile 
        195                 200                 205             


Ala Pro Lys Phe Thr Gly Arg Phe Asn Lys Gly Val Asp Tyr Val Gly 
    210                 215                 220                 


Asn Leu Thr Gln Phe Glu Arg Glu Phe Asn Gln Asp Ile Leu Val Ile 
225                 230                 235                 240 


Ala Tyr Ala Ser Lys Glu Phe Gly Leu Pro Lys Asn Leu Lys Leu Ser 
                245                 250                 255     


Val His Ser Gly Ser Asp Lys Phe Ser Ile Tyr Pro Ile Ile Lys Lys 
            260                 265                 270         


Ala Ile Tyr Thr His His Ala Gly Leu His Leu Lys Thr Ala Gly Thr 
        275                 280                 285             


Thr Trp Leu Glu Glu Leu Ile Gly Leu Ala Ser Ala Gly Asp Glu Gly 
    290                 295                 300                 


Leu Arg Ile Val Gln Gln Ile Tyr Arg Glu Thr Tyr Tyr Arg Phe Asp 
305                 310                 315                 320 


Glu Leu Cys Ala Pro Tyr Ala Thr Val Ile Asp Ile His Lys Asp Lys 
                325                 330                 335     


Leu Pro Glu Pro Asn Ser Val Gln Ala Trp Asn Gly Glu Thr Tyr Ala 
            340                 345                 350         


Ala Ala Leu Arg His Ile Glu Asn His Pro Gln Tyr Asn Pro His Phe 
        355                 360                 365             


Arg Gln Leu Leu His Val Gly Tyr Lys Val Ala Ala Glu Leu Gly Glu 
    370                 375                 380                 


Thr Tyr Leu Lys Ala Leu Glu Ala His Glu His His Ile Ala Leu Gln 
385                 390                 395                 400 


Val Lys Glu Asn Leu Leu Asp Arg His Ile Arg Pro Ile Phe Ile Gln 
                405                 410                 415     


<210>  373
<211>  472
<212>  PRT
<213>  Thermofilum uzonense

<400>  373

Met Leu Asp Thr Pro Arg Tyr Leu Gly Lys Leu Pro His Leu Ser Val 
1               5                   10                  15      


Gly Val Arg Leu Pro Glu Val Phe Leu Glu Gly Ile Met Ser Gly Phe 
            20                  25                  30          


Lys Thr Gly Asn Ser Ala Gly Gly Val Met Leu Ser Tyr His Arg Glu 
        35                  40                  45              


Thr Ala Pro Glu Tyr Val Ile Asn Ala Pro Pro Gly Asp Phe Glu Leu 
    50                  55                  60                  


Thr Arg Gly His Thr Gly Thr Ser Ile Arg His Tyr Ile Glu Ala Ser 
65                  70                  75                  80  


Val Ala Lys Ala Lys Glu Lys Gly Val Val Val Glu Val Glu Ala Asp 
                85                  90                  95      


His Val Ser Val Ser Val Ser Ser Glu Ala Val Lys Arg Ile Ser Gly 
            100                 105                 110         


Gly Gly Thr His Arg Val Leu Ser Glu Glu Glu Val Arg Ser Ala Leu 
        115                 120                 125             


Lys Tyr Ile Glu Asp Glu Ile Arg Glu Ala Val Ser Thr Arg Asn Ile 
    130                 135                 140                 


Tyr Phe Tyr Thr Ile Asp Thr Cys Asp Leu Ile Asp Tyr Ser Ser Glu 
145                 150                 155                 160 


Lys Ile Ala Val Asp Glu Leu Arg Thr Val Phe Lys Asp Leu Tyr Pro 
                165                 170                 175     


Ala Ser Leu Ile Glu Arg Tyr Lys Asp Ile Asn Val Val Val Asn Gly 
            180                 185                 190         


Thr Arg Ile Arg Phe Asp Glu Glu Lys Val Met Arg Leu Ser Leu Lys 
        195                 200                 205             


Leu Met Arg Ser Ile Asp Val Ser Glu Arg Ile Tyr Arg Ile Ile Lys 
    210                 215                 220                 


Glu Met Thr Pro Trp Pro Phe Gly Ile Glu Ile Ala Phe Asp Glu Thr 
225                 230                 235                 240 


Pro Val Thr Ser Asp Pro His Glu Leu Phe Phe Val Leu Asn Glu Leu 
                245                 250                 255     


Arg Thr Arg Gly Ile Pro Val Asp Phe Ile Ala Pro Asn Val Gly Phe 
            260                 265                 270         


Gln Lys Arg Glu Asp Phe Thr Gly Asp Leu Glu Thr Leu His Ser Arg 
        275                 280                 285             


Val Lys Thr Leu His Glu Val Ala Ser Phe Phe Gly Ser Leu Leu Ser 
    290                 295                 300                 


Phe His Ser Gly Ser Gly Ser Ser Pro Tyr Ser Met Lys Gly Lys Gly 
305                 310                 315                 320 


Val His Asp Ile Ile Arg Arg Ala Ala Gly Gly Leu Phe Lys Tyr Lys 
                325                 330                 335     


Ile Ser Gly Val Tyr Phe Glu Leu Leu Met Gln Leu Met Ser Arg Ser 
            340                 345                 350         


Asp Ile Pro Ser Val Arg Arg Leu Tyr Glu Glu Ile Tyr Asp Ala Val 
        355                 360                 365             


Ile Glu Leu Leu Glu Asp Gln Val Lys Arg Lys Gly Glu Leu Tyr Asp 
    370                 375                 380                 


Glu Val Leu Val Lys Arg Leu Glu Glu His Arg Lys Lys Ser Leu Asn 
385                 390                 395                 400 


Gly Tyr Val Arg Asp Ser Glu Ser Pro Val Phe Arg Tyr Tyr Ser Phe 
                405                 410                 415     


Leu Ala Leu Asn Ile Arg Arg Asn Gly Glu Arg Tyr Leu Arg Asn Ala 
            420                 425                 430         


Ile Val Glu Leu Tyr Leu Glu Asp Lys Gly Phe Arg Glu Gln Val Asp 
        435                 440                 445             


Arg Glu Ile Ser Ala Leu Thr Val Ala Phe Leu Asp Ser Leu Gly Phe 
    450                 455                 460                 


Arg Gly Asn Val Arg Leu Leu Arg 
465                 470         


<210>  374
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  374

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Thr Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  375
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  375

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Asn Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  376
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  376

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ala Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  377
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  377

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Trp Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  378
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  378

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Arg Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  379
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  379

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Pro His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  380
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  380

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Ala His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  381
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  381

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Gly Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  382
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  382

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro Gln Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  383
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  383

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro Ala Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  384
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  384

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro Lys Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  385
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  385

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Ala Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  386
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  386

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Gly His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  387
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  387

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Ser Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  388
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  388

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro Phe Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  389
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  389

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Ser Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  390
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  390

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Thr Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  391
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  391

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Ala Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  392
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  392

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Met Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  393
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  393

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Pro Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  394
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  394

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Asp Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  395
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  395

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ala Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  396
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  396

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gly Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  397
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  397

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile Asn Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  398
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  398

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile Gly Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  399
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  399

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile Pro Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  400
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  400

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Gly Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  401
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  401

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Glu Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  402
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  402

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Lys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  403
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  403

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile Ser Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  404
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  404

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Met Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  405
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  405

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Arg Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  406
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  406

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Thr Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  407
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  407

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Arg Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  408
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  408

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Lys Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  409
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  409

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Met Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  410
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  410

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Ile Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  411
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  411

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Leu Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  412
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  412

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Ala Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  413
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  413

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Val Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  414
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  414

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Thr Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  415
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  415

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asn Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  416
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  416

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Met Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  417
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  417

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Arg Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  418
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  418

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Lys Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  419
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  419

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Pro Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  420
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  420

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Thr Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  421
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  421

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Met Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  422
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  422

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Lys Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  423
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  423

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Tyr 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  424
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  424

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Val Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  425
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  425

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Phe 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  426
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  426

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Ser Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  427
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  427

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Arg Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  428
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  428

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Pro Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  429
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  429

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Pro Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  430
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  430

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Thr Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  431
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  431

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Lys Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  432
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  432

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Leu Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  433
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  433

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Arg Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  434
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  434

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Ser Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  435
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  435

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Gly Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  436
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  436

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Ala Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  437
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  437

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Thr Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  438
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  438

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Glu Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  439
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  439

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Pro Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  440
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  440

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Arg Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  441
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  441

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Tyr Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg His Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  442
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  442

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Val Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  443
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  443

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Ser Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


<210>  444
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D-fructose C4-epimerase

<400>  444

Met Trp Leu Ser Lys Asp Tyr Leu Arg Lys Lys Gly Val Tyr Ser Ile 
1               5                   10                  15      


Cys Ser Ser Asn Ser Tyr Val Ile Glu Ala Ser Ile Glu Phe Ala Lys 
            20                  25                  30          


Glu Lys Gly Asp Tyr Ile Leu Ile Glu Ala Thr Pro His Gln Val Asn 
        35                  40                  45              


Gln Phe Gly Gly Ala Ser Gly Met Thr Pro Glu Asp Phe Lys Asn Phe 
    50                  55                  60                  


Val Met Lys Ile Ala Lys Glu Lys Gly Leu Glu Glu Asp Lys Ile Ile 
65                  70                  75                  80  


Leu Gly Gly Asp His Leu Gly Pro Leu Pro Trp Gln Asp Glu Pro Ser 
                85                  90                  95      


Pro Thr Ala Met Asn Lys Ala Lys Asp Leu Ile Arg Ala Phe Val Glu 
            100                 105                 110         


Ser Gly Tyr Lys Lys Ile His Ile Asp Cys Ser Met Pro Leu Ser Asp 
        115                 120                 125             


Asp Pro Lys Val Leu Pro Tyr Glu Lys Ile Ala Glu Arg Thr Arg Glu 
    130                 135                 140                 


Leu Phe Glu Ile Ala Glu Glu Thr Ala Arg Lys Tyr Asn Phe Gln Pro 
145                 150                 155                 160 


Val Tyr Val Val Gly Thr Asp Val Pro Ile Ala Gly Gly Gly Glu Glu 
                165                 170                 175     


Glu Gly Val Thr Ser Val Glu Asp Phe Arg Ser Ala Ile Ser Ser Leu 
            180                 185                 190         


Lys Lys Tyr Phe Asn Asp Val Pro Asn Ile Trp Asp Arg Val Val Gly 
        195                 200                 205             


Phe Val Ile Met Leu Gly Ile Gly Phe Ser Tyr Asp Lys Val Phe Glu 
    210                 215                 220                 


Tyr Asp Arg Asp Lys Val Arg Gly Ile Leu Glu Glu Val Lys Arg Glu 
225                 230                 235                 240 


Asp Leu Phe Val Glu Gly His Ser Thr Asp Tyr Gln Ala Arg Tyr Ala 
                245                 250                 255     


Leu Arg Asn Met Val Glu Asp Gly Val Arg Ile Leu Lys Val Gly Pro 
            260                 265                 270         


Ala Leu Thr Ala Ala Phe Arg Arg Gly Val Phe Leu Leu Ser Asn Ile 
        275                 280                 285             


Glu Asp Glu Ile Ile Pro Glu Arg Glu Arg Ser Asn Ile Lys Arg Val 
    290                 295                 300                 


Ile Leu Glu Thr Met Leu Arg Asp Asp Arg Tyr Trp Arg Lys Tyr Tyr 
305                 310                 315                 320 


Lys Asp Ser Lys Arg Leu Glu Leu Asp Ile Trp Tyr Asn Leu Leu Asp 
                325                 330                 335     


Arg Ile Arg Tyr Tyr Trp Glu Tyr Glu Asp Val Lys Met Val Leu Asn 
            340                 345                 350         


Lys Leu Phe Glu Asn Phe Ser Glu Gly Val Asp Ile Lys Phe Ile Tyr 
        355                 360                 365             


Gln Tyr Phe Tyr Asp Ser Tyr Phe Asp Val Arg Glu Gly Lys Met Lys 
    370                 375                 380                 


Asn Asp Pro Arg Glu Leu Ile Lys Lys Glu Ile Lys Arg Val Leu Glu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Ala Ile Asn Leu 
                405             


