                         SEQUENCE LISTING

<110>  Baylor College of Medicine
 
<120>  IMMUNE STIMULATING COMPOSITIONS FOR THE TREATMENT AND PREVENTION 
       OF INFECTIONS WITH INTRACELLULAR PATHOGENS

<130>  BACM.P0007WO

<150>  US 62/694,427
<151>  2018-07-05

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  211
<212>  PRT
<213>  Trypanosoma cruzi

<400>  1

Met Gly Ala Cys Gly Ser Lys Gly Ser Thr Ser Asp Lys Gly Leu Ala 
1               5                   10                  15      


Ser Asp Lys Asp Gly Lys Asn Ala Lys Asp Arg Lys Glu Ala Trp Glu 
            20                  25                  30          


Pro Ile Arg Gln Ala Ile Pro Arg Glu Lys Thr Ala Glu Ala Lys Gln 
        35                  40                  45              


Arg Arg Ile Glu Leu Phe Lys Lys Phe Asp Lys Asn Glu Thr Gly Lys 
    50                  55                  60                  


Leu Cys Tyr Asp Glu Val Tyr Ser Gly Cys Leu Glu Val Leu Arg Leu 
65                  70                  75                  80  


Asp Glu Phe Thr Ser Gly Val Arg Asp Ile Thr Lys Arg Ala Phe Asp 
                85                  90                  95      


Lys Ala Arg Ala Leu Gly Ser Lys Leu Glu Asn Lys Gly Ser Glu Asp 
            100                 105                 110         


Phe Val Glu Phe Leu Glu Phe Arg Leu Met Leu Cys Tyr Ile Tyr Asp 
        115                 120                 125             


Phe Phe Glu Leu Thr Val Met Phe Asp Glu Ile Asp Ala Ser Gly Asn 
    130                 135                 140                 


Met Leu Val Asp Glu Glu Glu Phe Lys Arg Ala Val Pro Lys Leu Glu 
145                 150                 155                 160 


Ala Trp Gly Ala Lys Val Glu Asp Pro Ala Ala Leu Phe Lys Glu Leu 
                165                 170                 175     


Asp Lys Asn Gly Thr Gly Ser Val Thr Phe Asp Glu Phe Ala Ala Trp 
            180                 185                 190         


Ala Ser Ala Val Lys Leu Asp Ala Asp Gly Asp Pro Asp Asn Val Pro 
        195                 200                 205             


Glu Ser Ala 
    210     


<210>  2
<211>  633
<212>  DNA
<213>  Trypanosoma cruzi

<400>  2
atgggtgctt gtgggtcgaa gggctcgacg agcgacaagg ggttggcgag cgataaggac       60

ggcaagaacg ccaaggaccg caaggaagcg tgggagccca ttcgccaggc gattcctcgt      120

gagaagaccg ccgaggcaaa acagcgccgc atcgagctct tcaagaagtt cgacaagaac      180

gagaccggga agctgtgcta cgatgaggtg tacagcggct gcctcgaggt gctgaggttg      240

gacgagttca cgtcgggagt gcgcgacatc acgaagcgtg cattcgacaa ggcgagggcc      300

ctgggcagca agctggagaa caagggctcc gaggactttg ttgaatttct ggagttccgt      360

ctgatgctgt gctacatcta cgacttcttc gagctgacgg tgatgttcga cgagattgac      420

gcctccggca acatgctggt cgacgaggag gagttcaagc gcgccgtgcc caagcttgag      480

gcgtggggcg ccaaggtcga ggatcccgcg gcgctgttca aggagctcga taagaacggc      540

actgggtccg tgacgttcga cgagtttgct gcgtgggctt ctgcagtcaa actggacgcc      600

gacggcgacc cggacaacgt gccggagagc gcg                                   633


<210>  3
<211>  604
<212>  PRT
<213>  Mus musculus

<400>  3

Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Val Arg Trp Phe His Arg 
1               5                   10                  15      


Asp Leu Ser Gly Pro Asp Ala Glu Thr Leu Leu Lys Gly Arg Gly Val 
            20                  25                  30          


Pro Gly Ser Phe Leu Ala Arg Pro Ser Arg Lys Asn Gln Gly Asp Phe 
        35                  40                  45              


Ser Leu Ser Val Arg Val Asp Asp Gln Val Thr His Ile Arg Ile Gln 
    50                  55                  60                  


Asn Ser Gly Asp Phe Tyr Asp Leu Tyr Gly Gly Glu Lys Phe Ala Thr 
65                  70                  75                  80  


Leu Thr Glu Leu Val Glu Tyr Tyr Thr Gln Gln Gln Gly Ile Leu Gln 
                85                  90                  95      


Asp Arg Asp Gly Thr Ile Ile His Leu Lys Tyr Pro Leu Asn Cys Ser 
            100                 105                 110         


Asp Pro Thr Ser Glu Arg Trp Tyr His Gly His Ile Ser Gly Gly Gln 
        115                 120                 125             


Ala Glu Ser Leu Leu Gln Ala Lys Gly Glu Pro Trp Thr Phe Leu Val 
    130                 135                 140                 


Arg Glu Ser Leu Ser Gln Pro Gly Asp Phe Val Leu Ser Val Leu Asn 
145                 150                 155                 160 


Asp Gln Pro Lys Ala Gly Pro Gly Ser Pro Leu Arg Val Thr His Ile 
                165                 170                 175     


Lys Val Met Cys Glu Gly Gly Arg Tyr Thr Val Gly Gly Ser Glu Thr 
            180                 185                 190         


Phe Asp Ser Leu Thr Asp Leu Val Glu His Phe Lys Lys Thr Gly Ile 
        195                 200                 205             


Glu Glu Ala Ser Gly Ala Phe Val Tyr Leu Arg Gln Pro Tyr Tyr Ala 
    210                 215                 220                 


Thr Arg Val Asn Ala Ala Asp Ile Glu Asn Arg Val Leu Glu Leu Asn 
225                 230                 235                 240 


Lys Lys Gln Glu Ser Glu Asp Thr Ala Lys Ala Gly Phe Trp Glu Glu 
                245                 250                 255     


Phe Glu Ser Leu Gln Lys Gln Glu Val Lys Asn Leu His Gln Arg Leu 
            260                 265                 270         


Glu Gly Gln Arg Pro Glu Asn Lys Ser Lys Asn Arg Tyr Lys Asn Ile 
        275                 280                 285             


Leu Pro Phe Asp His Ser Arg Val Ile Leu Gln Gly Arg Asp Ser Asn 
    290                 295                 300                 


Ile Pro Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Val Lys Asn Gln Leu 
305                 310                 315                 320 


Leu Gly Pro Asp Glu Asn Ser Lys Thr Tyr Ile Ala Ser Gln Gly Cys 
                325                 330                 335     


Leu Asp Ala Thr Val Asn Asp Phe Trp Gln Met Ala Trp Gln Glu Asn 
            340                 345                 350         


Thr Arg Val Ile Val Met Thr Thr Arg Glu Val Glu Lys Gly Arg Asn 
        355                 360                 365             


Lys Cys Val Pro Tyr Trp Pro Glu Val Gly Thr Gln Arg Val Tyr Gly 
    370                 375                 380                 


Leu Tyr Ser Val Thr Asn Ser Arg Glu His Asp Thr Ala Glu Tyr Lys 
385                 390                 395                 400 


Leu Arg Thr Leu Gln Ile Ser Pro Leu Asp Asn Gly Asp Leu Val Arg 
                405                 410                 415     


Glu Ile Trp His Tyr Gln Tyr Leu Ser Trp Pro Asp His Gly Val Pro 
            420                 425                 430         


Ser Glu Pro Gly Gly Val Leu Ser Phe Leu Asp Gln Ile Asn Gln Arg 
        435                 440                 445             


Gln Glu Ser Leu Pro His Ala Gly Pro Ile Ile Val His Ser Ser Ala 
    450                 455                 460                 


Gly Ile Gly Arg Thr Gly Thr Ile Ile Val Ile Asp Met Leu Met Glu 
465                 470                 475                 480 


Ser Ile Ser Thr Lys Gly Leu Asp Cys Asp Ile Asp Ile Gln Lys Thr 
                485                 490                 495     


Ile Gln Met Val Arg Ala Gln Arg Ser Gly Met Val Gln Thr Glu Ala 
            500                 505                 510         


Gln Tyr Lys Phe Ile Tyr Val Ala Ile Ala Gln Phe Ile Glu Thr Thr 
        515                 520                 525             


Lys Lys Lys Leu Glu Ile Ile Gln Ser Gln Lys Gly Gln Glu Ser Glu 
    530                 535                 540                 


Tyr Gly Asn Ile Thr Tyr Pro Pro Ala Val Arg Ser Ala His Ala Lys 
545                 550                 555                 560 


Ala Ser Arg Thr Ser Ser Lys His Lys Glu Glu Val Tyr Glu Asn Val 
                565                 570                 575     


His Ser Lys Ser Lys Lys Glu Glu Lys Val Lys Lys Gln Arg Ser Ala 
            580                 585                 590         


Asp Lys Glu Lys Asn Lys Gly Ser Leu Lys Arg Lys 
        595                 600                 


<210>  4
<211>  1812
<212>  DNA
<213>  Mus musculus

<400>  4
atgtacccat atgacgttcc agactacgcg gtgaggtggt ttcaccggga cctcagcggg       60

cctgatgcag agaccctgct gaagggccgg ggagtccctg ggagcttcct ggctcggccc      120

agccgcaaga accagggtga cttctccctc tcagtcaggg tggatgatca ggtgactcat      180

attcggatcc agaactcagg ggacttctat gacctgtacg gaggggagaa gtttgcgacg      240

ctgacagagc tggtcgagta ttacacgcag cagcagggca tcctgcagga ccgagatggc      300

accatcatcc accttaagta cccactgaac tgctcggacc ccaccagtga gaggtggtac      360

cacggccaca tatctggagg gcaggcggag tcactgctgc aggccaaggg cgagccctgg      420

acatttcttg tgcgtgagag tctcagccaa cctggtgatt ttgtgctctc tgtgctcaat      480

gaccagccca aggctggccc aggttccccg ctcagggtca ctcatatcaa ggttatgtgt      540

gagggtggac gctatactgt gggtggctca gagacgtttg acagcctcac agacctggtg      600

gagcacttca agaagacagg gattgaggag gcctcgggtg cctttgtcta cctgcggcag      660

ccttactacg ctactcgggt aaacgcagct gacattgaga atcgggtctt ggaactgaac      720

aagaagcagg agtcggagga cacagccaag gctggcttct gggaggagtt tgagagtcta      780

caaaagcagg aggtaaagaa tctacaccaa cgtctggaag ggcagcggcc agagaacaag      840

agcaagaacc gctacaagaa cattcttccc tttgaccaca gccgagtgat cctgcaggga      900

cgtgacagta acatcccagg ctctgactac atcaatgcca actacgtgaa gaaccagctg      960

ctaggtccag atgagaactc taagacctac atcgccagcc agggctgtct ggatgccaca     1020

gtcaatgact tctggcagat ggcttggcag gagaacactc gtgtcatcgt catgactacc     1080

agagaggtgg agaaaggccg gaacaaatgt gtcccatact ggcccgaggt gggcactcag     1140

cgtgtctatg gtctctactc tgtgaccaac agtagggagc atgacacagc agaatacaaa     1200

ctgcgaacat tacagatctc cccactagac aatggggacc tggttcggga gatatggcac     1260

taccagtacc tgagctggcc tgaccatggg gttcccagtg agcctggggg tgtcctcagc     1320

tttctggatc agatcaacca gcgacaggaa agtttgcctc atgcagggcc catcattgtg     1380

cattccagcg ctggcatcgg ccgcacgggc accatcatcg tcattgatat gcttatggaa     1440

agcatctcca ccaaggggct agactgtgac attgatatcc agaagaccat ccagatggta     1500

cgagcacagc gctccggcat ggtgcagacc gaggcccagt acaagtttat ttacgtggcc     1560

attgcccagt tcatcgaaac gaccaagaag aaactggaga tcatacaatc ccagaagggc     1620

caggagtcgg agtatgggaa tatcacgtac cctcccgctg tgaggagtgc ccacgccaaa     1680

gcctcgcgta cttcctccaa gcacaaggag gaggtgtacg aaaacgtgca tagcaagagc     1740

aagaaggaag agaaagtaaa gaagcagcgg tcggcagaca aggagaagaa caaaggttct     1800

ctcaagagga ag                                                         1812


<210>  5
<211>  589
<212>  PRT
<213>  Trypanosoma cruzi

<400>  5

Met Glu Arg Asn Ser Gly Asp Leu Gln Leu Pro Gln Glu Ile Ala Met 
1               5                   10                  15      


Leu Val Pro Asn Lys Thr Gln Val Val Pro Lys Ser Gly Gly Glu Gly 
            20                  25                  30          


Lys Val Lys Asp Ile Phe Ala Ser Pro Ala Leu Val Arg Ala Gly Gly 
        35                  40                  45              


Val Met Ile Ala Phe Val Glu Gly Arg Thr Lys Asn Lys Leu Phe Pro 
    50                  55                  60                  


Glu Val Ile Asp Leu Ser Ser Ser Asp Ile Val Ala Gly Tyr Ile Lys 
65                  70                  75                  80  


Ala Pro Glu Thr Trp Gln Ser Leu Val Ala Glu Val Thr Lys Glu Tyr 
                85                  90                  95      


Trp Gln Ala His Thr Val Leu Glu Ser Ala Asn Asn Ser Asn His Arg 
            100                 105                 110         


Val Gly Val Ala Arg Leu Pro Thr Gly Ile Thr Arg Gly Asn Lys Val 
        115                 120                 125             


Phe Leu Leu Val Gly Ser Tyr Glu Glu Arg Arg Glu Ile Asp Asp Tyr 
    130                 135                 140                 


Ile Trp Lys Ala Glu Ala Trp Asn Ile Lys Val Ile Glu Gly Glu Ala 
145                 150                 155                 160 


Thr Gln Ser Thr Glu Val Gln Pro Thr Gln Pro Ile Asn Trp Ser Glu 
                165                 170                 175     


Pro Lys Pro Leu Phe Gln Thr Asp Ser Pro Asn Asn Lys Gly Asp Leu 
            180                 185                 190         


Lys Glu Phe Leu Gly Gly Gly Gly Ser Gly Ile Val Met Gly Asn Gly 
        195                 200                 205             


Thr Leu Val Phe Pro Leu Thr Ala Lys Asp Glu Ser Asn Lys Val Phe 
    210                 215                 220                 


Ser Leu Ile Thr Tyr Ser Thr Asp Asp Gly Gln Lys Trp Glu Ile Pro 
225                 230                 235                 240 


Gly Gly Val Ser Ser Val Ala Cys Arg Ser Pro Arg Val Thr Glu Trp 
                245                 250                 255     


Glu Glu Gly Thr Leu Leu Met Val Thr Tyr Cys Glu Asp Gly Arg Lys 
            260                 265                 270         


Val Phe Glu Ser Arg Asp Met Gly Lys Thr Trp Thr Glu Ala Phe Gly 
        275                 280                 285             


Thr Leu Pro Gly Val Trp Leu Lys Ser Gly Pro Glu Leu Pro Glu Val 
    290                 295                 300                 


Ser Leu Arg Val Asp Ala Leu Ile Thr Ala Thr Ile Glu Gly Arg Lys 
305                 310                 315                 320 


Val Met Leu Tyr Thr Gln Lys Val Arg His Phe Leu Glu Val Asp Glu 
                325                 330                 335     


Pro Asn Ala Leu His Leu Trp Val Thr Asp Asn Asn Arg Thr Phe His 
            340                 345                 350         


Leu Gly Pro Phe Ser Val Asp Cys Ala Glu Asn Lys Thr Phe Ala Asn 
        355                 360                 365             


Thr Leu Leu Tyr Ser Asp Asp Ala Leu His Leu Leu Gln Ala Lys Gly 
    370                 375                 380                 


Asp His Glu Ser Thr Ala Val Ser Leu Ala Arg Leu Thr Glu Glu Leu 
385                 390                 395                 400 


Asn Thr Ile Asn Ser Val Leu Ser Thr Trp Val Gln Leu Asp Ala Ser 
                405                 410                 415     


Phe Ser Glu Ser Ser Ile Pro Thr Ala Gly Leu Val Gly Phe Leu Ser 
            420                 425                 430         


Asn Thr Thr Ser Ser Gly Asp Thr Trp Ile Asp Gly Tyr Arg Cys Met 
        435                 440                 445             


Asn Ala Thr Val Thr Lys Ala Ala Lys Val Glu Asn Gly Phe Lys Phe 
    450                 455                 460                 


Thr Gly Pro Gly Ser Arg Ala Thr Trp Pro Val Asn Ser Arg Trp Asp 
465                 470                 475                 480 


Ile Lys Gln Tyr Gly Phe Val Asp Tyr Asn Phe Thr Ile Val Ala Met 
                485                 490                 495     


Ala Thr Ile His Gln Val Pro Ser Glu Ser Thr Pro Leu Leu Gly Ala 
            500                 505                 510         


Ser Leu Arg Gly Asn Lys Arg Thr Lys Leu Ile Gly Leu Ser Tyr Gly 
        515                 520                 525             


Ala Gly Gly Lys Trp Glu Thr Val Tyr Asp Gly Thr Lys Thr Val Gln 
    530                 535                 540                 


Gly Gly Thr Trp Glu Pro Gly Arg Glu Tyr Gln Val Ala Leu Met Leu 
545                 550                 555                 560 


Gln Asp Gly Asn Lys Gly Phe Val Tyr Val Asp Gly Val Leu Val Gly 
                565                 570                 575     


Asn Pro Ala Met Leu Pro Thr Pro Glu Glu Arg Trp Thr 
            580                 585                 


<210>  6
<211>  1767
<212>  DNA
<213>  Trypanosoma cruzi

<400>  6
atggagagaa actcagggga tttgcaactg ccgcaggaga tcgccatgct tgtgccgaat       60

aagacgcagg tggtaccaaa aagtggtggt gaaggcaaag tgaaggatat ctttgcttca      120

cccgctctcg tccgtgctgg tggagtgatg attgcatttg tcgaaggccg caccaaaaat      180

aaactttttc cagaagtgat tgatctcagt tcttctgata ttgttgccgg ttacatcaag      240

gctccagaga catggcagtc tcttgttgct gaggtaacca aagagtactg gcaggcacac      300

actgtccttg agagtgcgaa taatagtaat catcgtgtgg gtgttgcgag gctacccacc      360

ggaattacaa ggggcaataa agtgtttctg ctagtgggga gctatgaaga gaggcgtgaa      420

attgatgatt atatttggaa ggccgaggca tggaacatta aagtgattga gggtgaggcc      480

acgcagtcca cggaagttca gccgactcaa ccgatcaact ggagtgaacc caaaccgctg      540

ttccaaactg actctcctaa taataaaggt gacctaaagg aatttttggg tggtggtggc      600

tcaggaattg tgatggggaa tggcacactt gtgtttcccc tgacggcaaa ggatgaaagt      660

aataaagttt tctccctaat cacttattcg acggacgacg gccaaaagtg ggagatacca      720

gggggcgttt cttctgtggc atgccgttcc ccccgcgtca ccgaatggga ggagggaaca      780

cttctcatgg ttacttattg cgaggatggc cgcaaggtgt ttgagtcgcg tgacatgggg      840

aaaacgtgga cggaggcttt tgggacactc ccaggcgtgt ggctcaaatc aggtccagaa      900

cttccggaag taagtttgcg tgttgatgct ctcatcaccg cgaccattga gggaaggaag      960

gtcatgctgt acactcagaa agtgaggcat tttctggaag tggatgaacc caacgcactc     1020

cacctttggg tcacggacaa caaccgcact tttcatcttg gaccgttttc tgtggactgt     1080

gctgagaata agacgtttgc caacaccttg ctgtactcgg atgatgcgtt gcacctttta     1140

caagcgaagg gcgatcatga aagcacagcc gtttcacttg cccgcctaac ggaggagctg     1200

aatacgatca attctgtcct tagtacttgg gtacagttgg acgcttcctt ctccgagtcg     1260

tctataccca cggctggtct ggttggattc ctgtccaata cgacgtccag tggagacacg     1320

tggatcgacg ggtaccgttg catgaatgca acggtgacga aggcagcgaa ggttgaaaat     1380

ggtttcaagt tcacggggcc tgggtccagg gcaacatggc ccgtaaacag tcggtgggat     1440

attaaacagt acggctttgt ggattacaac ttcactattg tggcgatggc gactatacac     1500

caggttccga gtgagagcac tcctctgctg ggtgcgagtc tgaggggcaa taagaggacg     1560

aagttaattg gtttgtcgta cggtgcgggc ggtaagtggg agacagtgta tgacgggaca     1620

aaaacagtac agggtggcac ttgggagccg gggagagaat accaggtggc gctcatgctg     1680

caggacggca acaagggctt cgtgtacgtg gatggtgtgc ttgtggggaa cccggcgatg     1740

ttaccaacac ctgaggagcg gtggact                                         1767


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
aatcggctga tcgttttcga                                                   20


<210>  8
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
aattcctcca agcagcggat a                                                 21


<210>  9
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  9
cacacactgg acaccaa                                                      17


<210>  10
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
caatgtgtcc gtcgtggatc t                                                 21


<210>  11
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
gtcctcagtg tagcccaaga tg                                                22


<210>  12
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
cgtgccgcct ggagaaacct gcc                                               23


