                         SEQUENCE LISTING

<110>  Unum Therapeutics Inc.
       McGinness, Kathleen
       Ettenberg, Seth
       Barron, Luke
       Fray, Michael
       Wilson, Charles
       Motz, Gregory
 
<120>  CHIMERIC RECEPTORS IN COMBINATION WITH TRANS METABOLISM MOLECULES
        ENHANCING GLUCOSE IMPORT AND THERAPEUTIC USES THEREOF

<130>  103068-627889 (70011WO00)

<140>  PCT/US2019/040346
<141>  2019-07-02

<150>  62/693,668
<151>  2018-07-03

<150>  62/756,664
<151>  2018-11-07

<150>  62/693,677
<151>  2018-07-03

<150>  62/713,369
<151>  2018-08-01

<150>  62/756,698
<151>  2018-11-07

<160>  105   

<170>  PatentIn version 3.5

<210>  1
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Arg Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Glu Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala 
        195                 200                 205             


Tyr Ser Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Ala Asp Lys Ser 
    210                 215                 220                 


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  2
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu 
            260                 265                 270         


Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly 
        275                 280                 285             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    290                 295                 300                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
305                 310                 315                 320 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                325                 330                 335     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            340                 345                 350         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        355                 360                 365             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    370                 375                 380                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
385                 390                 395                 400 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                405                 410                 415     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            420                 425                 430         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440         


<210>  3
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
            260                 265                 270         


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
        275                 280                 285             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    290                 295                 300                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
305                 310                 315                 320 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                325                 330                 335     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            340                 345                 350         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        355                 360                 365             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    370                 375                 380                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
385                 390                 395                 400 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                405                 410                 415     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            420                 425                 430         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440         


<210>  4
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
            260                 265                 270         


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  5
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Leu Leu Ala Ala Leu Leu Ala Leu Leu Ala Ala Leu Leu Ala 
            260                 265                 270         


Leu Leu Ala Ala Leu Leu Ala Arg Ser Lys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  6
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ala Ala Ala Pro Pro Lys Ala Val Leu Lys 
            20                  25                  30          


Leu Glu Pro Pro Trp Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu 
        35                  40                  45              


Thr Cys Gln Gly Ala Arg Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe 
    50                  55                  60                  


His Asn Gly Asn Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe 
65                  70                  75                  80  


Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln 
                85                  90                  95      


Thr Ser Leu Ser Asp Pro Val His Leu Thr Val Leu Ser Glu Trp Leu 
            100                 105                 110         


Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu Gly Glu Thr Ile Met 
        115                 120                 125             


Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe 
    130                 135                 140                 


Phe Gln Asn Gly Lys Ser Gln Lys Phe Ser His Leu Asp Pro Thr Phe 
145                 150                 155                 160 


Ser Ile Pro Gln Ala Asn His Ser His Ser Gly Asp Tyr His Cys Thr 
                165                 170                 175     


Gly Asn Ile Gly Tyr Thr Leu Phe Ser Ser Lys Pro Val Thr Ile Thr 
            180                 185                 190         


Val Gln Val Pro Ser Met Gly Ser Ser Ser Pro Met Gly Thr Thr Thr 
        195                 200                 205             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    210                 215                 220                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
225                 230                 235                 240 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                245                 250                 255     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            260                 265                 270         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        275                 280                 285             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    290                 295                 300                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
305                 310                 315                 320 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                325                 330                 335     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            340                 345                 350         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        355                 360                 365             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    370                 375                 380                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
385                 390                 395                 400 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                405                 410                 415     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425             


<210>  7
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
        275                 280                 285             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    290                 295                 300                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
305                 310                 315                 320 


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                325                 330                 335     


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            340                 345                 350         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        355                 360                 365             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    370                 375                 380                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
385                 390                 395                 400 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                405                 410                 415     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            420                 425                 430         


Pro Pro Arg 
        435 


<210>  8
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Ala Leu Tyr Leu Leu Arg 
        275                 280                 285             


Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly 
    290                 295                 300                 


Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr 
305                 310                 315                 320 


Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  9
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
        275                 280                 285             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    290                 295                 300                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
305                 310                 315                 320 


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                325                 330                 335     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            340                 345                 350         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        355                 360                 365             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    370                 375                 380                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
385                 390                 395                 400 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                405                 410                 415     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            420                 425                 430         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        435                 440                 445             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    450                 455                 460                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475         


<210>  10
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    210                 215                 220                 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
225                 230                 235                 240 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                245                 250                 255     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            260                 265                 270         


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        275                 280                 285             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    290                 295                 300                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
305                 310                 315                 320 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                325                 330                 335     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            340                 345                 350         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        355                 360                 365             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    370                 375                 380                 


Met Gln Ala Leu Pro Pro Arg 
385                 390     


<210>  11
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 
    210                 215                 220                 


Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 
225                 230                 235                 240 


Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 
                245                 250                 255     


Pro Thr Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  12
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
        275                 280                 285             


Gly Gly His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    290                 295                 300                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
305                 310                 315                 320 


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                325                 330                 335     


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            340                 345                 350         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        355                 360                 365             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    370                 375                 380                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
385                 390                 395                 400 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                405                 410                 415     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            420                 425                 430         


Pro Pro Arg 
        435 


<210>  13
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
        275                 280                 285             


Gly Gly His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    290                 295                 300                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
305                 310                 315                 320 


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                325                 330                 335     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            340                 345                 350         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        355                 360                 365             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    370                 375                 380                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
385                 390                 395                 400 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                405                 410                 415     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            420                 425                 430         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        435                 440                 445             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    450                 455                 460                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475         


<210>  14
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu 
            260                 265                 270         


Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Lys Arg Gly Arg Lys 
        275                 280                 285             


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
    290                 295                 300                 


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
305                 310                 315                 320 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                325                 330                 335     


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            340                 345                 350         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        355                 360                 365             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    370                 375                 380                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
385                 390                 395                 400 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                405                 410                 415     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            420                 425                 430         


Ala Leu Pro Pro Arg 
        435         


<210>  15
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu 
            260                 265                 270         


Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  16
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly Ile 
            260                 265                 270         


Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  17
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Leu Leu Leu Ile Leu Leu Gly Val Leu Ala Gly Val Leu Ala 
            260                 265                 270         


Thr Leu Ala Ala Leu Leu Ala Arg Ser Lys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  18
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu 
            260                 265                 270         


Val Ser Leu Gly Val Ala Ile His Leu Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  19
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp 
            260                 265                 270         


Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  20
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu 
            260                 265                 270         


Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  21
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val 
            260                 265                 270         


Ile Leu Thr Ala Leu Phe Leu Arg Val Lys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  22
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile 
            260                 265                 270         


Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys 
        275                 280                 285             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    290                 295                 300                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
305                 310                 315                 320 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                325                 330                 335     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            340                 345                 350         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        355                 360                 365             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    370                 375                 380                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
385                 390                 395                 400 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                405                 410                 415     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            420                 425                 430         


Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440     


<210>  23
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala 
            260                 265                 270         


Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  24
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu Leu Ala 
            260                 265                 270         


Leu Gly Val Phe Cys Phe Ala Gly His Glu Thr Lys Arg Gly Arg Lys 
        275                 280                 285             


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
    290                 295                 300                 


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
305                 310                 315                 320 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                325                 330                 335     


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            340                 345                 350         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        355                 360                 365             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    370                 375                 380                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
385                 390                 395                 400 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                405                 410                 415     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            420                 425                 430         


Ala Leu Pro Pro Arg 
        435         


<210>  25
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
            260                 265                 270         


Asn Leu Leu Met Thr Leu Arg Leu Trp Lys Arg Gly Arg Lys Lys Leu 
        275                 280                 285             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    290                 295                 300                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
305                 310                 315                 320 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                325                 330                 335     


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            340                 345                 350         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        355                 360                 365             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    370                 375                 380                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
385                 390                 395                 400 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                405                 410                 415     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            420                 425                 430         


Pro Pro Arg 
        435 


<210>  26
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Ile Val Ala Val Val Ile Ala Thr Ala Val Ala Ala Ile 
            260                 265                 270         


Val Ala Ala Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Gly Arg 
        275                 280                 285             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    290                 295                 300                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
305                 310                 315                 320 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                325                 330                 335     


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            340                 345                 350         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        355                 360                 365             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    370                 375                 380                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
385                 390                 395                 400 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                405                 410                 415     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            420                 425                 430         


Gln Ala Leu Pro Pro Arg 
        435             


<210>  27
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu Val Asn 
            260                 265                 270         


Thr Val Leu Trp Val Thr Ile Arg Lys Glu Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  28
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Ile Ile Leu Val Gly Thr Ala Val Ile Ala Met Phe Phe 
            260                 265                 270         


Trp Leu Leu Leu Val Ile Ile Leu Arg Thr Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  29
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Leu Gly Trp Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile 
            260                 265                 270         


Val Trp Val Lys Arg Lys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        275                 280                 285             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    290                 295                 300                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
305                 310                 315                 320 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                325                 330                 335     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            340                 345                 350         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        355                 360                 365             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    370                 375                 380                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
385                 390                 395                 400 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                405                 410                 415     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430         


<210>  30
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala Cys Met 
            260                 265                 270         


Val Val Thr Val Ile Leu Cys Arg Met Lys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  31
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Phe Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  32
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Asp Thr Thr Lys Ala Val Ile Thr Leu 
            20                  25                  30          


Gln Pro Pro Trp Val Ser Val Phe Gln Glu Glu Thr Val Thr Leu His 
        35                  40                  45              


Cys Glu Val Leu His Leu Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu 
    50                  55                  60                  


Asn Gly Thr Ala Thr Gln Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser 
65                  70                  75                  80  


Ala Ser Val Asn Asp Ser Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser 
                85                  90                  95      


Gly Arg Ser Asp Pro Ile Gln Leu Glu Ile His Arg Gly Trp Leu Leu 
            100                 105                 110         


Leu Gln Val Ser Ser Arg Val Phe Thr Glu Gly Glu Pro Leu Ala Leu 
        115                 120                 125             


Arg Cys His Ala Trp Lys Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr 
    130                 135                 140                 


Arg Asn Gly Lys Ala Phe Lys Phe Phe His Trp Asn Ser Asn Leu Thr 
145                 150                 155                 160 


Ile Leu Lys Thr Asn Ile Ser His Asn Gly Thr Tyr His Cys Ser Gly 
                165                 170                 175     


Met Gly Lys His Arg Tyr Thr Ser Ala Gly Ile Ser Val Thr Val Lys 
            180                 185                 190         


Glu Leu Phe Pro Ala Pro Val Leu Asn Ala Ser Val Thr Ser Pro Leu 
        195                 200                 205             


Leu Glu Gly Asn Leu Val Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu 
    210                 215                 220                 


Gln Arg Pro Gly Leu Gln Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys 
225                 230                 235                 240 


Thr Leu Arg Gly Arg Asn Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala 
                245                 250                 255     


Arg Arg Glu Asp Ser Gly Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp 
            260                 265                 270         


Gly Asn Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln Val Leu Gly 
        275                 280                 285             


Leu Gln Leu Pro Thr Pro Val Trp Phe His Ile Tyr Ile Trp Ala Pro 
    290                 295                 300                 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
305                 310                 315                 320 


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
                325                 330                 335     


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
            340                 345                 350         


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
        355                 360                 365             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    370                 375                 380                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
385                 390                 395                 400 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                405                 410                 415     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            420                 425                 430         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        435                 440                 445             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    450                 455                 460                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475     


<210>  33
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Tyr Ile 
        435                 440                 445             


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    450                 455                 460                 


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
465                 470                 475                 480 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                485                 490                 495     


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            500                 505                 510         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        515                 520                 525             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    530                 535                 540                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
545                 550                 555                 560 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                565                 570                 575     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            580                 585                 590         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        595                 600                 605             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620             


<210>  34
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
225                 230                 235                 240 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                245                 250                 255     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            260                 265                 270         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        275                 280                 285             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    290                 295                 300                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
305                 310                 315                 320 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Tyr Ile Trp 
                325                 330                 335     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            340                 345                 350         


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  35
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
225                 230                 235                 240 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                245                 250                 255     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            260                 265                 270         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        275                 280                 285             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    290                 295                 300                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
305                 310                 315                 320 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                325                 330                 335     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            340                 345                 350         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        355                 360                 365             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    370                 375                 380                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
385                 390                 395                 400 


Pro Pro Arg 
            


<210>  36
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Phe 
225                 230                 235                 240 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                245                 250                 255     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
            260                 265                 270         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        275                 280                 285             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    290                 295                 300                 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
305                 310                 315                 320 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                325                 330                 335     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            340                 345                 350         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        355                 360                 365             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    370                 375                 380                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
385                 390                 395                 400 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                405                 410                 415     


Ala Leu Pro Pro Arg 
            420     


<210>  37
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
225                 230                 235                 240 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                245                 250                 255     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            260                 265                 270         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        275                 280                 285             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    290                 295                 300                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
305                 310                 315                 320 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                325                 330                 335     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            340                 345                 350         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        355                 360                 365             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    370                 375                 380                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
385                 390                 395                 400 


Gln Ala Leu Pro Pro Arg 
                405     


<210>  38
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
225                 230                 235                 240 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                245                 250                 255     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            260                 265                 270         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        275                 280                 285             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    290                 295                 300                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
305                 310                 315                 320 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                325                 330                 335     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            340                 345                 350         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        355                 360                 365             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    370                 375                 380                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
385                 390                 395                 400 


Gln Ala Leu Pro Pro Arg 
                405     


<210>  39
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                245                 250                 255     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
            260                 265                 270         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        275                 280                 285             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    290                 295                 300                 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
305                 310                 315                 320 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                325                 330                 335     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            340                 345                 350         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        355                 360                 365             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    370                 375                 380                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
385                 390                 395                 400 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                405                 410                 415     


Ala Leu Pro Pro Arg 
            420     


<210>  40
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  41
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
        275                 280                 285             


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
    290                 295                 300                 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
305                 310                 315                 320 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
                325                 330                 335     


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            340                 345                 350         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        355                 360                 365             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    370                 375                 380                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                405                 410                 415     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            420                 425                 430         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        435                 440                 445             


Pro Pro Arg 
    450     


<210>  42
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 
    210                 215                 220                 


Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 
225                 230                 235                 240 


Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 
                245                 250                 255     


Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 
            260                 265                 270         


Ala Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
        275                 280                 285             


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
    290                 295                 300                 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
305                 310                 315                 320 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
                325                 330                 335     


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            340                 345                 350         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        355                 360                 365             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    370                 375                 380                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                405                 410                 415     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            420                 425                 430         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        435                 440                 445             


Pro Pro Arg 
    450     


<210>  43
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 
    210                 215                 220                 


Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 
225                 230                 235                 240 


Ser Thr Glu Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                245                 250                 255     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
            260                 265                 270         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        275                 280                 285             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    290                 295                 300                 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
305                 310                 315                 320 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                325                 330                 335     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            340                 345                 350         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        355                 360                 365             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    370                 375                 380                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
385                 390                 395                 400 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                405                 410                 415     


Ala Leu Pro Pro Arg 
            420     


<210>  44
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 
    210                 215                 220                 


Glu Glu Gly Thr Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
225                 230                 235                 240 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                245                 250                 255     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            260                 265                 270         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        275                 280                 285             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    290                 295                 300                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
305                 310                 315                 320 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                325                 330                 335     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            340                 345                 350         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        355                 360                 365             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    370                 375                 380                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
385                 390                 395                 400 


Gln Ala Leu Pro Pro Arg 
                405     


<210>  45
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu 
            20                  25                  30          


Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys 
        35                  40                  45              


Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His 
    50                  55                  60                  


Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala 
65                  70                  75                  80  


Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser 
                85                  90                  95      


Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu 
            100                 105                 110         


Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu 
        115                 120                 125             


Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu 
    130                 135                 140                 


Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr 
145                 150                 155                 160 


Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly 
                165                 170                 175     


Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile 
            180                 185                 190         


Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly 
        195                 200                 205             


Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    210                 215                 220                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
225                 230                 235                 240 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
                245                 250                 255     


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            260                 265                 270         


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        275                 280                 285             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    290                 295                 300                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
305                 310                 315                 320 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                325                 330                 335     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            340                 345                 350         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        355                 360                 365             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    370                 375                 380                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
385                 390                 395                 400 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                405                 410                 415     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            420                 425                 430         


Arg 
    


<210>  46
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  46

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  47
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  47

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    210                 215                 220                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
225                 230                 235                 240 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
                245                 250                 255     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            260                 265                 270         


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        275                 280                 285             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    290                 295                 300                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
305                 310                 315                 320 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                325                 330                 335     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            340                 345                 350         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        355                 360                 365             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    370                 375                 380                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
385                 390                 395                 400 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                405                 410                 415     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430     


<210>  48
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Cys Trp Leu Thr Lys Lys 
        275                 280                 285             


Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe Met 
    290                 295                 300                 


Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu 
305                 310                 315                 320 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                325                 330                 335     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            340                 345                 350         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        355                 360                 365             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    370                 375                 380                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
385                 390                 395                 400 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                405                 410                 415     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430         


<210>  49
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  49

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Gln Arg Arg Lys Tyr Arg 
        275                 280                 285             


Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr 
    290                 295                 300                 


Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp 
305                 310                 315                 320 


Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro Arg Val Lys Phe Ser Arg 
                325                 330                 335     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            340                 345                 350         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        355                 360                 365             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    370                 375                 380                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
385                 390                 395                 400 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                405                 410                 415     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            420                 425                 430         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440         


<210>  50
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Gln Leu Gly Leu His Ile 
        275                 280                 285             


Trp Gln Leu Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu 
    290                 295                 300                 


Leu Glu Val Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro 
305                 310                 315                 320 


Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly 
                325                 330                 335     


Asp Leu Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            340                 345                 350         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        355                 360                 365             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    370                 375                 380                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                405                 410                 415     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            420                 425                 430         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        435                 440                 445             


Leu Pro Pro Arg 
    450         


<210>  51
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Cys Val Lys Arg Arg Lys 
        275                 280                 285             


Pro Arg Gly Asp Val Val Lys Val Ile Val Ser Val Gln Arg Lys Arg 
    290                 295                 300                 


Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu Ala Leu Gln Ala Pro 
305                 310                 315                 320 


Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr Ile Pro Ser Phe Thr 
                325                 330                 335     


Gly Arg Ser Pro Asn His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            340                 345                 350         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        355                 360                 365             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    370                 375                 380                 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                405                 410                 415     


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            420                 425                 430         


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        435                 440                 445             


Gln Ala Leu Pro Pro Arg 
    450                 


<210>  52
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Lys Tyr Phe Phe Lys 
        275                 280                 285             


Lys Glu Val Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln Ile Lys 
    290                 295                 300                 


Ala Leu Gln Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp Asn Ile 
305                 310                 315                 320 


Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp Arg Val Lys Phe Ser Arg 
                325                 330                 335     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            340                 345                 350         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        355                 360                 365             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    370                 375                 380                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
385                 390                 395                 400 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                405                 410                 415     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            420                 425                 430         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440         


<210>  53
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  53

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Tyr Lys Val Gly Phe Phe 
        275                 280                 285             


Lys Arg Asn Leu Lys Glu Lys Met Glu Ala Gly Arg Gly Val Pro Asn 
    290                 295                 300                 


Gly Ile Pro Ala Glu Asp Ser Glu Gln Leu Ala Ser Gly Gln Glu Ala 
305                 310                 315                 320 


Gly Asp Pro Gly Cys Leu Lys Pro Leu His Glu Lys Asp Ser Glu Ser 
                325                 330                 335     


Gly Gly Gly Lys Asp Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            340                 345                 350         


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        355                 360                 365             


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    370                 375                 380                 


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
                405                 410                 415     


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
            420                 425                 430         


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
        435                 440                 445             


Ala Leu Pro Pro Arg 
    450             


<210>  54
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  54

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Lys Lys Gln Arg 
        275                 280                 285             


Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val Ala 
    290                 295                 300                 


Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr Pro 
305                 310                 315                 320 


Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His Arg 
                325                 330                 335     


Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val Gln 
            340                 345                 350         


His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val His 
        355                 360                 365             


Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro 
    370                 375                 380                 


Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  55
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  55

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr 
            260                 265                 270         


Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg 
        275                 280                 285             


Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly 
    290                 295                 300                 


Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys 
305                 310                 315                 320 


Pro Pro Gln Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                325                 330                 335     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            340                 345                 350         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        355                 360                 365 


<210>  56
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  56

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr 
                325                 330                 335     


Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn 
            340                 345                 350         


Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
        355                 360                 365     


<210>  57
<211>  864
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  57

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
    210                 215                 220                 


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
225                 230                 235                 240 


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
                245                 250                 255     


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
            260                 265                 270         


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
        275                 280                 285             


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
    290                 295                 300                 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
305                 310                 315                 320 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                325                 330                 335     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            340                 345                 350         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        355                 360                 365             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    370                 375                 380                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
385                 390                 395                 400 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                405                 410                 415     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430         


Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
        435                 440                 445             


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
    450                 455                 460                 


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
465                 470                 475                 480 


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
                485                 490                 495     


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
            500                 505                 510         


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
        515                 520                 525             


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
    530                 535                 540                 


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
545                 550                 555                 560 


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
                565                 570                 575     


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
            580                 585                 590         


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
        595                 600                 605             


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
    610                 615                 620                 


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
625                 630                 635                 640 


Pro Pro Gly Tyr Gln Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
                645                 650                 655     


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
            660                 665                 670         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        675                 680                 685             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    690                 695                 700                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
705                 710                 715                 720 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                725                 730                 735     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            740                 745                 750         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        755                 760                 765             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    770                 775                 780                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
785                 790                 795                 800 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                805                 810                 815     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            820                 825                 830         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        835                 840                 845             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    850                 855                 860                 


<210>  58
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  58

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    210                 215                 220                 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
225                 230                 235                 240 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
                245                 250                 255     


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
            260                 265                 270         


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        275                 280                 285             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    290                 295                 300                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
305                 310                 315                 320 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                325                 330                 335     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            340                 345                 350         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        355                 360                 365             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    370                 375                 380                 


Gln Ala Leu Pro Pro Arg 
385                 390 


<210>  59
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  59

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
        275                 280                 285             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    290                 295                 300                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
305                 310                 315                 320 


Tyr Arg Ser Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro 
                325                 330                 335     


Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu 
            340                 345                 350         


Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala 
        355                 360                 365             


Cys Ser Pro Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  60
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  60

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
        275                 280                 285             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    290                 295                 300                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
305                 310                 315                 320 


Tyr Arg Ser Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
                325                 330                 335     


Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp 
            340                 345                 350         


Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala 
        355                 360                 365             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    370                 375                 380                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
385                 390                 395                 400 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                405                 410                 415     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            420                 425                 430         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        435                 440                 445             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    450                 455                 460                 


His Met Gln Ala Leu Pro Pro Arg 
465                 470         


<210>  61
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  61

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
                325                 330                 335     


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
            340                 345                 350         


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
        355                 360                 365             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    370                 375                 380                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
385                 390                 395                 400 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                405                 410                 415     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            420                 425                 430         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        435                 440                 445             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    450                 455                 460                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475         


<210>  62
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  62

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
    210                 215                 220                 


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
225                 230                 235                 240 


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
                245                 250                 255     


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
            260                 265                 270         


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
        275                 280                 285             


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
    290                 295                 300                 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
305                 310                 315                 320 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                325                 330                 335     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            340                 345                 350         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
        355                 360                 365             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
385                 390                 395                 400 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                405                 410                 415     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            420                 425                 430         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        435                 440                 445             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    450                 455                 460                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 


<210>  63
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  63

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
    210                 215                 220                 


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
225                 230                 235                 240 


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
                245                 250                 255     


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
            260                 265                 270         


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        275                 280                 285             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    290                 295                 300                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
305                 310                 315                 320 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                325                 330                 335     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            340                 345                 350         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        355                 360                 365             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    370                 375                 380                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
385                 390                 395                 400 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                405                 410                 415     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            420                 425                 430         


Arg 
    


<210>  64
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  64

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Gln Arg Arg Lys Tyr Arg 
        275                 280                 285             


Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro Cys His Tyr 
    290                 295                 300                 


Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp 
305                 310                 315                 320 


Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro Arg Val Lys Phe Ser Arg 
                325                 330                 335     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            340                 345                 350         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        355                 360                 365             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    370                 375                 380                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
385                 390                 395                 400 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                405                 410                 415     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            420                 425                 430         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440         


<210>  65
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  65

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
        275                 280                 285             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    290                 295                 300                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
305                 310                 315                 320 


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                325                 330                 335     


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            340                 345                 350         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        355                 360                 365             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    370                 375                 380                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
385                 390                 395                 400 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                405                 410                 415     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            420                 425                 430         


Pro Pro Arg 
        435 


<210>  66
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  66

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Lys Lys Tyr Ser Ser 
        275                 280                 285             


Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn 
    290                 295                 300                 


Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Arg Val Lys Phe 
305                 310                 315                 320 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                325                 330                 335     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            340                 345                 350         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        355                 360                 365             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    370                 375                 380                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
385                 390                 395                 400 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                405                 410                 415     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425             


<210>  67
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  67

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Arg Asp Gln Arg Leu 
        275                 280                 285             


Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro 
    290                 295                 300                 


Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg 
305                 310                 315                 320 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                325                 330                 335     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            340                 345                 350         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        355                 360                 365             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    370                 375                 380                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
385                 390                 395                 400 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                405                 410                 415     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430     


<210>  68
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  68

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
        275                 280                 285             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    290                 295                 300                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
305                 310                 315                 320 


Tyr Arg Ser Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly 
                325                 330                 335     


Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu 
            340                 345                 350         


Thr Asp Val Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
        355                 360                 365             


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
    370                 375                 380                 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
385                 390                 395                 400 


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                405                 410                 415     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            420                 425                 430         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        435                 440                 445             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    450                 455                 460                 


Ala Leu Pro Pro Arg 
465                 


<210>  69
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  69

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    210                 215                 220                 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
225                 230                 235                 240 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                245                 250                 255     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            260                 265                 270         


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        275                 280                 285             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    290                 295                 300                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
305                 310                 315                 320 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                325                 330                 335     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            340                 345                 350         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        355                 360                 365             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    370                 375                 380                 


Met Gln Ala Leu Pro Pro Arg 
385                 390     


<210>  70
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  70

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    210                 215                 220                 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Gln Arg Arg 
225                 230                 235                 240 


Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro 
                245                 250                 255     


Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile 
            260                 265                 270         


Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro Arg Val Lys 
        275                 280                 285             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    290                 295                 300                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
305                 310                 315                 320 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                325                 330                 335     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            340                 345                 350         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        355                 360                 365             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    370                 375                 380                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
385                 390                 395         


<210>  71
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  71

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    210                 215                 220                 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Lys Lys 
225                 230                 235                 240 


Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg 
                245                 250                 255     


Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Arg 
            260                 265                 270         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        275                 280                 285             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    290                 295                 300                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
305                 310                 315                 320 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                325                 330                 335     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            340                 345                 350         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        355                 360                 365             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375                 380             


<210>  72
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  72

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    210                 215                 220                 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Arg Asp 
225                 230                 235                 240 


Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe 
                245                 250                 255     


Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala 
            260                 265                 270         


Lys Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        275                 280                 285             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    290                 295                 300                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
305                 310                 315                 320 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                325                 330                 335     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            340                 345                 350         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        355                 360                 365             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    370                 375                 380                 


Pro Arg 
385     


<210>  73
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  73

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
    210                 215                 220                 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
225                 230                 235                 240 


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
                245                 250                 255     


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            260                 265                 270         


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
        275                 280                 285             


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
    290                 295                 300                 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
305                 310                 315                 320 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                325                 330                 335     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            340                 345                 350         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        355                 360                 365             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    370                 375                 380                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
385                 390                 395 


<210>  74
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  74

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
    210                 215                 220                 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
225                 230                 235                 240 


Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
                245                 250                 255     


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
            260                 265                 270         


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
        275                 280                 285             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    290                 295                 300                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
305                 310                 315                 320 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                325                 330                 335     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            340                 345                 350         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        355                 360                 365             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    370                 375                 380                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
385                 390                 


<210>  75
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  75

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
            260                 265                 270         


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
        275                 280                 285             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    290                 295                 300                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
305                 310                 315                 320 


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                325                 330                 335     


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            340                 345                 350         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        355                 360                 365             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    370                 375                 380                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
385                 390                 395                 400 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                405                 410                 415     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            420                 425                 430         


Gln Ala Leu Pro Pro Arg 
        435             


<210>  76
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  76

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
    210                 215                 220                 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
225                 230                 235                 240 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                245                 250                 255     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
            260                 265                 270         


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
        275                 280                 285             


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
    290                 295                 300                 


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
305                 310                 315                 320 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                325                 330                 335     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            340                 345                 350         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        355                 360                 365             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    370                 375                 380                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
385                 390                 395                 400 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                405                 410                 415     


Pro Pro Arg 
            


<210>  77
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  77

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
    210                 215                 220                 


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
225                 230                 235                 240 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                245                 250                 255     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            260                 265                 270         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        275                 280                 285             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    290                 295                 300                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
305                 310                 315                 320 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                325                 330                 335     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            340                 345                 350         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        355                 360                 365             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    370                 375                 380                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
385                 390                 395                 400 


Leu His Met Gln Ala Leu Pro Pro Arg 
                405                 


<210>  78
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  78

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    210                 215                 220                 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
225                 230                 235                 240 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                245                 250                 255     


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            260                 265                 270         


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
        275                 280                 285             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    290                 295                 300                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
305                 310                 315                 320 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                325                 330                 335     


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            340                 345                 350         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        355                 360                 365             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    370                 375                 380                 


Leu His Met Gln Ala Leu Pro Pro Arg 
385                 390             


<210>  79
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  79

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  80
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  80

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
    210                 215                 220                 


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
225                 230                 235                 240 


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Ile Tyr Ile Trp 
                245                 250                 255     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            260                 265                 270         


Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        275                 280                 285             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    290                 295                 300                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
305                 310                 315                 320 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                325                 330                 335     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            340                 345                 350         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        355                 360                 365             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    370                 375                 380                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
385                 390                 395                 400 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                405                 410                 415     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 


<210>  81
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Glu Pro Ser Ser Lys Lys Leu Thr Gly Arg Leu Met Leu Ala Val 
1               5                   10                  15      


Gly Gly Ala Val Leu Gly Ser Leu Gln Phe Gly Tyr Asn Thr Gly Val 
            20                  25                  30          


Ile Asn Ala Pro Gln Lys Val Ile Glu Glu Phe Tyr Asn Gln Thr Trp 
        35                  40                  45              


Val His Arg Tyr Gly Glu Ser Ile Leu Pro Thr Thr Leu Thr Thr Leu 
    50                  55                  60                  


Trp Ser Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser 
65                  70                  75                  80  


Phe Ser Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met 
                85                  90                  95      


Leu Met Met Asn Leu Leu Ala Phe Val Ser Ala Val Leu Met Gly Phe 
            100                 105                 110         


Ser Lys Leu Gly Lys Ser Phe Glu Met Leu Ile Leu Gly Arg Phe Ile 
        115                 120                 125             


Ile Gly Val Tyr Cys Gly Leu Thr Thr Gly Phe Val Pro Met Tyr Val 
    130                 135                 140                 


Gly Glu Val Ser Pro Thr Ala Leu Arg Gly Ala Leu Gly Thr Leu His 
145                 150                 155                 160 


Gln Leu Gly Ile Val Val Gly Ile Leu Ile Ala Gln Val Phe Gly Leu 
                165                 170                 175     


Asp Ser Ile Met Gly Asn Lys Asp Leu Trp Pro Leu Leu Leu Ser Ile 
            180                 185                 190         


Ile Phe Ile Pro Ala Leu Leu Gln Cys Ile Val Leu Pro Phe Cys Pro 
        195                 200                 205             


Glu Ser Pro Arg Phe Leu Leu Ile Asn Arg Asn Glu Glu Asn Arg Ala 
    210                 215                 220                 


Lys Ser Val Leu Lys Lys Leu Arg Gly Thr Ala Asp Val Thr His Asp 
225                 230                 235                 240 


Leu Gln Glu Met Lys Glu Glu Ser Arg Gln Met Met Arg Glu Lys Lys 
                245                 250                 255     


Val Thr Ile Leu Glu Leu Phe Arg Ser Pro Ala Tyr Arg Gln Pro Ile 
            260                 265                 270         


Leu Ile Ala Val Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn 
        275                 280                 285             


Ala Val Phe Tyr Tyr Ser Thr Ser Ile Phe Glu Lys Ala Gly Val Gln 
    290                 295                 300                 


Gln Pro Val Tyr Ala Thr Ile Gly Ser Gly Ile Val Asn Thr Ala Phe 
305                 310                 315                 320 


Thr Val Val Ser Leu Phe Val Val Glu Arg Ala Gly Arg Arg Thr Leu 
                325                 330                 335     


His Leu Ile Gly Leu Ala Gly Met Ala Gly Cys Ala Ile Leu Met Thr 
            340                 345                 350         


Ile Ala Leu Ala Leu Leu Glu Gln Leu Pro Trp Met Ser Tyr Leu Ser 
        355                 360                 365             


Ile Val Ala Ile Phe Gly Phe Val Ala Phe Phe Glu Val Gly Pro Gly 
    370                 375                 380                 


Pro Ile Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg 
385                 390                 395                 400 


Pro Ala Ala Ile Ala Val Ala Gly Phe Ser Asn Trp Thr Ser Asn Phe 
                405                 410                 415     


Ile Val Gly Met Cys Phe Gln Tyr Val Glu Gln Leu Cys Gly Pro Tyr 
            420                 425                 430         


Val Phe Ile Ile Phe Thr Val Leu Leu Val Leu Phe Phe Ile Phe Thr 
        435                 440                 445             


Tyr Phe Lys Val Pro Glu Thr Lys Gly Arg Thr Phe Asp Glu Ile Ala 
    450                 455                 460                 


Ser Gly Phe Arg Gln Gly Gly Ala Ser Gln Ser Asp Lys Thr Pro Glu 
465                 470                 475                 480 


Glu Leu Phe His Pro Leu Gly Ala Asp Ser Gln Val 
                485                 490         


<210>  82
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Glu Pro Ser Ser Lys Lys Leu Thr Gly Arg Leu Met Leu Ala Val 
1               5                   10                  15      


Gly Gly Ala Val Leu Gly Ser Leu Gln Phe Gly Tyr Asn Thr Gly Val 
            20                  25                  30          


Ile Asn Ala Pro Gln Lys Val Ile Glu Glu Phe Tyr Asn Gln Thr Trp 
        35                  40                  45              


Val His Arg Tyr Gly Glu Ser Ile Leu Pro Thr Thr Leu Thr Thr Leu 
    50                  55                  60                  


Trp Ser Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser 
65                  70                  75                  80  


Phe Ser Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met 
                85                  90                  95      


Leu Met Met Asn Leu Leu Ala Phe Val Ser Ala Val Leu Met Gly Phe 
            100                 105                 110         


Ser Lys Leu Gly Lys Ser Phe Glu Met Leu Ile Leu Gly Arg Phe Ile 
        115                 120                 125             


Ile Gly Val Tyr Cys Gly Leu Thr Thr Gly Phe Val Pro Met Tyr Val 
    130                 135                 140                 


Gly Glu Val Ser Pro Thr Ala Leu Arg Gly Ala Leu Gly Thr Leu His 
145                 150                 155                 160 


Gln Leu Gly Ile Val Val Gly Ile Leu Ile Ala Gln Val Phe Gly Leu 
                165                 170                 175     


Asp Ser Ile Met Gly Asn Lys Asp Leu Trp Pro Leu Leu Leu Ser Ile 
            180                 185                 190         


Ile Phe Ile Pro Ala Leu Leu Gln Cys Ile Val Leu Pro Phe Cys Pro 
        195                 200                 205             


Glu Ser Pro Arg Phe Leu Leu Ile Asn Arg Asn Glu Glu Asn Arg Ala 
    210                 215                 220                 


Lys Asp Val Leu Lys Lys Leu Arg Gly Thr Ala Asp Val Thr His Asp 
225                 230                 235                 240 


Leu Gln Glu Met Lys Glu Glu Ser Arg Gln Met Met Arg Glu Lys Lys 
                245                 250                 255     


Val Thr Ile Leu Glu Leu Phe Arg Ser Pro Ala Tyr Arg Gln Pro Ile 
            260                 265                 270         


Leu Ile Ala Val Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn 
        275                 280                 285             


Ala Val Phe Tyr Tyr Ser Thr Ser Ile Phe Glu Lys Ala Gly Val Gln 
    290                 295                 300                 


Gln Pro Val Tyr Ala Thr Ile Gly Ser Gly Ile Val Asn Thr Ala Phe 
305                 310                 315                 320 


Thr Val Val Ser Leu Phe Val Val Glu Arg Ala Gly Arg Arg Thr Leu 
                325                 330                 335     


His Leu Ile Gly Leu Ala Gly Met Ala Gly Cys Ala Ile Leu Met Thr 
            340                 345                 350         


Ile Ala Leu Ala Leu Leu Glu Gln Leu Pro Trp Met Ser Tyr Leu Ser 
        355                 360                 365             


Ile Val Ala Ile Phe Gly Phe Val Ala Phe Phe Glu Val Gly Pro Gly 
    370                 375                 380                 


Pro Ile Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg 
385                 390                 395                 400 


Pro Ala Ala Ile Ala Val Ala Gly Phe Ser Asn Trp Thr Ser Asn Phe 
                405                 410                 415     


Ile Val Gly Met Cys Phe Gln Tyr Val Glu Gln Leu Cys Gly Pro Tyr 
            420                 425                 430         


Val Phe Ile Ile Phe Thr Val Leu Leu Val Leu Phe Phe Ile Phe Thr 
        435                 440                 445             


Tyr Phe Lys Val Pro Glu Thr Lys Gly Arg Thr Phe Asp Glu Ile Ala 
    450                 455                 460                 


Ser Gly Phe Arg Gln Gly Gly Ala Ser Gln Ser Asp Lys Thr Pro Glu 
465                 470                 475                 480 


Glu Leu Phe His Pro Leu Gly Ala Asp Ser Gln Val 
                485                 490         


<210>  83
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Gly Thr Gln Lys Val Thr Pro Ala Leu Ile Phe Ala Ile Thr Val 
1               5                   10                  15      


Ala Thr Ile Gly Ser Phe Gln Phe Gly Tyr Asn Thr Gly Val Ile Asn 
            20                  25                  30          


Ala Pro Glu Lys Ile Ile Lys Glu Phe Ile Asn Lys Thr Leu Thr Asp 
        35                  40                  45              


Lys Gly Asn Ala Pro Pro Ser Glu Val Leu Leu Thr Ser Leu Trp Ser 
    50                  55                  60                  


Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser Phe Ser 
65                  70                  75                  80  


Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met Leu Ile 
                85                  90                  95      


Val Asn Leu Leu Ala Val Thr Gly Gly Cys Phe Met Gly Leu Cys Lys 
            100                 105                 110         


Val Ala Lys Ser Val Glu Met Leu Ile Leu Gly Arg Leu Val Ile Gly 
        115                 120                 125             


Leu Phe Cys Gly Leu Cys Thr Gly Phe Val Pro Met Tyr Ile Gly Glu 
    130                 135                 140                 


Ile Ser Pro Thr Ala Leu Arg Gly Ala Phe Gly Thr Leu Asn Gln Leu 
145                 150                 155                 160 


Gly Ile Val Val Gly Ile Leu Val Ala Gln Ile Phe Gly Leu Glu Phe 
                165                 170                 175     


Ile Leu Gly Ser Glu Glu Leu Trp Pro Leu Leu Leu Gly Phe Thr Ile 
            180                 185                 190         


Leu Pro Ala Ile Leu Gln Ser Ala Ala Leu Pro Phe Cys Pro Glu Ser 
        195                 200                 205             


Pro Arg Phe Leu Leu Ile Asn Arg Lys Glu Glu Glu Asn Ala Lys Gln 
    210                 215                 220                 


Ile Leu Gln Arg Leu Trp Gly Thr Gln Asp Val Ser Gln Asp Ile Gln 
225                 230                 235                 240 


Glu Met Lys Asp Glu Ser Ala Arg Met Ser Gln Glu Lys Gln Val Thr 
                245                 250                 255     


Val Leu Glu Leu Phe Arg Val Ser Ser Tyr Arg Gln Pro Ile Ile Ile 
            260                 265                 270         


Ser Ile Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn Ala Val 
        275                 280                 285             


Phe Tyr Tyr Ser Thr Gly Ile Phe Lys Asp Ala Gly Val Gln Glu Pro 
    290                 295                 300                 


Ile Tyr Ala Thr Ile Gly Ala Gly Val Val Asn Thr Ile Phe Thr Val 
305                 310                 315                 320 


Val Ser Leu Phe Leu Val Glu Arg Ala Gly Arg Arg Thr Leu His Met 
                325                 330                 335     


Ile Gly Leu Gly Gly Met Ala Phe Cys Ser Thr Leu Met Thr Val Ser 
            340                 345                 350         


Leu Leu Leu Lys Asp Asn Tyr Asn Gly Met Ser Phe Val Cys Ile Gly 
        355                 360                 365             


Ala Ile Leu Val Phe Val Ala Phe Phe Glu Ile Gly Pro Gly Pro Ile 
    370                 375                 380                 


Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg Pro Ala 
385                 390                 395                 400 


Ala Met Ala Val Ala Gly Cys Ser Asn Trp Thr Ser Asn Phe Leu Val 
                405                 410                 415     


Gly Leu Leu Phe Pro Ser Ala Ala His Tyr Leu Gly Ala Tyr Val Phe 
            420                 425                 430         


Ile Ile Phe Thr Gly Phe Leu Ile Thr Phe Leu Ala Phe Thr Phe Phe 
        435                 440                 445             


Lys Val Pro Glu Thr Arg Gly Arg Thr Phe Glu Asp Ile Thr Arg Ala 
    450                 455                 460                 


Phe Glu Gly Gln Ala His Gly Ala Asp Arg Ser Gly Lys Asp Gly Val 
465                 470                 475                 480 


Met Glu Met Asn Ser Ile Glu Pro Ala Lys Glu Thr Thr Thr Asn Val 
                485                 490                 495     


<210>  84
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Pro Ser Gly Phe Gln Gln Ile Gly Ser Glu Asp Gly Glu Pro Pro 
1               5                   10                  15      


Gln Gln Arg Val Thr Gly Thr Leu Val Leu Ala Val Phe Ser Ala Val 
            20                  25                  30          


Leu Gly Ser Leu Gln Phe Gly Tyr Asn Ile Gly Val Ile Asn Ala Pro 
        35                  40                  45              


Gln Lys Val Ile Glu Gln Ser Tyr Asn Glu Thr Trp Leu Gly Arg Gln 
    50                  55                  60                  


Gly Pro Glu Gly Pro Ser Ser Ile Pro Pro Gly Thr Leu Thr Thr Leu 
65                  70                  75                  80  


Trp Ala Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Ser Ser 
                85                  90                  95      


Phe Leu Ile Gly Ile Ile Ser Gln Trp Leu Gly Arg Lys Arg Ala Met 
            100                 105                 110         


Leu Val Asn Asn Val Leu Ala Val Leu Gly Gly Ser Leu Met Gly Leu 
        115                 120                 125             


Ala Asn Ala Ala Ala Ser Tyr Glu Met Leu Ile Leu Gly Arg Phe Leu 
    130                 135                 140                 


Ile Gly Ala Tyr Ser Gly Leu Thr Ser Gly Leu Val Pro Met Tyr Val 
145                 150                 155                 160 


Gly Glu Ile Ala Pro Thr His Leu Arg Gly Ala Leu Gly Thr Leu Asn 
                165                 170                 175     


Gln Leu Ala Ile Val Ile Gly Ile Leu Ile Ala Gln Val Leu Gly Leu 
            180                 185                 190         


Glu Ser Leu Leu Gly Thr Ala Ser Leu Trp Pro Leu Leu Leu Gly Leu 
        195                 200                 205             


Thr Val Leu Pro Ala Leu Leu Gln Leu Val Leu Leu Pro Phe Cys Pro 
    210                 215                 220                 


Glu Ser Pro Arg Tyr Leu Tyr Ile Ile Gln Asn Leu Glu Gly Pro Ala 
225                 230                 235                 240 


Arg Lys Ser Leu Lys Arg Leu Thr Gly Trp Ala Asp Val Ser Gly Val 
                245                 250                 255     


Leu Ala Glu Leu Lys Asp Glu Lys Arg Lys Leu Glu Arg Glu Arg Pro 
            260                 265                 270         


Leu Ser Leu Leu Gln Leu Leu Gly Ser Arg Thr His Arg Gln Pro Leu 
        275                 280                 285             


Ile Ile Ala Val Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn 
    290                 295                 300                 


Ala Val Phe Tyr Tyr Ser Thr Ser Ile Phe Glu Thr Ala Gly Val Gly 
305                 310                 315                 320 


Gln Pro Ala Tyr Ala Thr Ile Gly Ala Gly Val Val Asn Thr Val Phe 
                325                 330                 335     


Thr Leu Val Ser Val Leu Leu Val Glu Arg Ala Gly Arg Arg Thr Leu 
            340                 345                 350         


His Leu Leu Gly Leu Ala Gly Met Cys Gly Cys Ala Ile Leu Met Thr 
        355                 360                 365             


Val Ala Leu Leu Leu Leu Glu Arg Val Pro Ala Met Ser Tyr Val Ser 
    370                 375                 380                 


Ile Val Ala Ile Phe Gly Phe Val Ala Phe Phe Glu Ile Gly Pro Gly 
385                 390                 395                 400 


Pro Ile Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg 
                405                 410                 415     


Pro Ala Ala Met Ala Val Ala Gly Phe Ser Asn Trp Thr Ser Asn Phe 
            420                 425                 430         


Ile Ile Gly Met Gly Phe Gln Tyr Val Ala Glu Ala Met Gly Pro Tyr 
        435                 440                 445             


Val Phe Leu Leu Phe Ala Val Leu Leu Leu Gly Phe Phe Ile Phe Thr 
    450                 455                 460                 


Phe Leu Arg Val Pro Glu Thr Arg Gly Arg Thr Phe Asp Gln Ile Ser 
465                 470                 475                 480 


Ala Ala Phe His Arg Thr Pro Ser Leu Leu Glu Gln Glu Val Lys Pro 
                485                 490                 495     


Ser Thr Glu Leu Glu Tyr Leu Gly Pro Asp Glu Asn Asp 
            500                 505                 


<210>  85
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Glu Asn Lys Glu Ala Gly Thr Pro Pro Pro Ile Pro Ser Arg Glu 
1               5                   10                  15      


Gly Arg Leu Gln Pro Thr Leu Leu Leu Ala Thr Leu Ser Ala Ala Phe 
            20                  25                  30          


Gly Ser Ala Phe Gln Tyr Gly Tyr Asn Leu Ser Val Val Asn Thr Pro 
        35                  40                  45              


His Lys Val Phe Lys Ser Phe Tyr Asn Glu Thr Tyr Phe Glu Arg His 
    50                  55                  60                  


Ala Thr Phe Met Asp Gly Lys Leu Met Leu Leu Leu Trp Ser Cys Thr 
65                  70                  75                  80  


Val Ser Met Phe Pro Leu Gly Gly Leu Leu Gly Ser Leu Leu Val Gly 
                85                  90                  95      


Leu Leu Val Asp Ser Cys Gly Arg Lys Gly Thr Leu Leu Ile Asn Asn 
            100                 105                 110         


Ile Phe Ala Ile Ile Pro Ala Ile Leu Met Gly Val Ser Lys Val Ala 
        115                 120                 125             


Lys Ala Phe Glu Leu Ile Val Phe Ser Arg Val Val Leu Gly Val Cys 
    130                 135                 140                 


Ala Gly Ile Ser Tyr Ser Ala Leu Pro Met Tyr Leu Gly Glu Leu Ala 
145                 150                 155                 160 


Pro Lys Asn Leu Arg Gly Met Val Gly Thr Met Thr Glu Val Phe Val 
                165                 170                 175     


Ile Val Gly Val Phe Leu Ala Gln Ile Phe Ser Leu Gln Ala Ile Leu 
            180                 185                 190         


Gly Asn Pro Ala Gly Trp Pro Val Leu Leu Ala Leu Thr Gly Val Pro 
        195                 200                 205             


Ala Leu Leu Gln Leu Leu Thr Leu Pro Phe Phe Pro Glu Ser Pro Arg 
    210                 215                 220                 


Tyr Ser Leu Ile Gln Lys Gly Asp Glu Ala Thr Ala Arg Gln Ala Leu 
225                 230                 235                 240 


Arg Arg Leu Arg Gly His Thr Asp Met Glu Ala Glu Leu Glu Asp Met 
                245                 250                 255     


Arg Ala Glu Ala Arg Ala Glu Arg Ala Glu Gly His Leu Ser Val Leu 
            260                 265                 270         


His Leu Cys Ala Leu Arg Ser Leu Arg Trp Gln Leu Leu Ser Ile Ile 
        275                 280                 285             


Val Leu Met Ala Gly Gln Gln Leu Ser Gly Ile Asn Ala Ile Asn Tyr 
    290                 295                 300                 


Tyr Ala Asp Thr Ile Tyr Thr Ser Ala Gly Val Glu Ala Ala His Ser 
305                 310                 315                 320 


Gln Tyr Val Thr Val Gly Ser Gly Val Val Asn Ile Val Met Thr Ile 
                325                 330                 335     


Thr Ser Ala Val Leu Val Glu Arg Leu Gly Arg Arg His Leu Leu Leu 
            340                 345                 350         


Ala Gly Tyr Gly Ile Cys Gly Ser Ala Cys Leu Val Leu Thr Val Val 
        355                 360                 365             


Leu Leu Phe Gln Asn Arg Val Pro Glu Leu Ser Tyr Leu Gly Ile Ile 
    370                 375                 380                 


Cys Val Phe Ala Tyr Ile Ala Gly His Ser Ile Gly Pro Ser Pro Val 
385                 390                 395                 400 


Pro Ser Val Val Arg Thr Glu Ile Phe Leu Gln Ser Ser Arg Arg Ala 
                405                 410                 415     


Ala Phe Met Val Asp Gly Ala Val His Trp Leu Thr Asn Phe Ile Ile 
            420                 425                 430         


Gly Phe Leu Phe Pro Ser Ile Gln Glu Ala Ile Gly Ala Tyr Ser Phe 
        435                 440                 445             


Ile Ile Phe Ala Gly Ile Cys Leu Leu Thr Ala Ile Tyr Ile Tyr Val 
    450                 455                 460                 


Val Ile Pro Glu Thr Lys Gly Lys Thr Phe Val Glu Ile Asn Arg Ile 
465                 470                 475                 480 


Phe Ala Lys Arg Asn Arg Val Lys Leu Pro Glu Glu Lys Glu Glu Thr 
                485                 490                 495     


Ile Asp Ala Gly Pro Pro Thr Ala Ser Pro Ala Lys Glu Thr Ser Phe 
            500                 505                 510         


<210>  86
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Thr Pro Glu Asp Pro Glu Glu Thr Gln Pro Leu Leu Gly Pro Pro 
1               5                   10                  15      


Gly Gly Ser Ala Pro Arg Gly Arg Arg Val Phe Leu Ala Ala Phe Ala 
            20                  25                  30          


Ala Ala Leu Gly Pro Leu Ser Phe Gly Phe Ala Leu Gly Tyr Ser Ser 
        35                  40                  45              


Pro Ala Ile Pro Ser Leu Gln Arg Ala Ala Pro Pro Ala Pro Arg Leu 
    50                  55                  60                  


Asp Asp Ala Ala Ala Ser Trp Phe Gly Ala Val Val Thr Leu Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Gly Val Leu Gly Gly Trp Leu Val Asp Arg Ala Gly Arg 
                85                  90                  95      


Lys Leu Ser Leu Leu Leu Cys Ser Val Pro Phe Val Ala Gly Phe Ala 
            100                 105                 110         


Val Ile Thr Ala Ala Gln Asp Val Trp Met Leu Leu Gly Gly Arg Leu 
        115                 120                 125             


Leu Thr Gly Leu Ala Cys Gly Val Ala Ser Leu Val Ala Pro Val Tyr 
    130                 135                 140                 


Ile Ser Glu Ile Ala Tyr Pro Ala Val Arg Gly Leu Leu Gly Ser Cys 
145                 150                 155                 160 


Val Gln Leu Met Val Val Val Gly Ile Leu Leu Ala Tyr Leu Ala Gly 
                165                 170                 175     


Trp Val Leu Glu Trp Arg Trp Leu Ala Val Leu Gly Cys Val Pro Pro 
            180                 185                 190         


Ser Leu Met Leu Leu Leu Met Cys Phe Met Pro Glu Thr Pro Arg Phe 
        195                 200                 205             


Leu Leu Thr Gln His Arg Arg Gln Glu Ala Met Ala Ala Leu Arg Phe 
    210                 215                 220                 


Leu Trp Gly Ser Glu Gln Gly Trp Glu Asp Pro Pro Ile Gly Ala Glu 
225                 230                 235                 240 


Gln Ser Phe His Leu Ala Leu Leu Arg Gln Pro Gly Ile Tyr Lys Pro 
                245                 250                 255     


Phe Ile Ile Gly Val Ser Leu Met Ala Phe Gln Gln Leu Ser Gly Val 
            260                 265                 270         


Asn Ala Val Met Phe Tyr Ala Glu Thr Ile Phe Glu Glu Ala Lys Phe 
        275                 280                 285             


Lys Asp Ser Ser Leu Ala Ser Val Val Val Gly Val Ile Gln Val Leu 
    290                 295                 300                 


Phe Thr Ala Val Ala Ala Leu Ile Met Asp Arg Ala Gly Arg Arg Leu 
305                 310                 315                 320 


Leu Leu Val Leu Ser Gly Val Val Met Val Phe Ser Thr Ser Ala Phe 
                325                 330                 335     


Gly Ala Tyr Phe Lys Leu Thr Gln Gly Gly Pro Gly Asn Ser Ser His 
            340                 345                 350         


Val Ala Ile Ser Ala Pro Val Ser Ala Gln Pro Val Asp Ala Ser Val 
        355                 360                 365             


Gly Leu Ala Trp Leu Ala Val Gly Ser Met Cys Leu Phe Ile Ala Gly 
    370                 375                 380                 


Phe Ala Val Gly Trp Gly Pro Ile Pro Trp Leu Leu Met Ser Glu Ile 
385                 390                 395                 400 


Phe Pro Leu His Val Lys Gly Val Ala Thr Gly Ile Cys Val Leu Thr 
                405                 410                 415     


Asn Trp Leu Met Ala Phe Leu Val Thr Lys Glu Phe Ser Ser Leu Met 
            420                 425                 430         


Glu Val Leu Arg Pro Tyr Gly Ala Phe Trp Leu Ala Ser Ala Phe Cys 
        435                 440                 445             


Ile Phe Ser Val Leu Phe Thr Leu Phe Cys Val Pro Glu Thr Lys Gly 
    450                 455                 460                 


Lys Thr Leu Glu Gln Ile Thr Ala His Phe Glu Gly Arg 
465                 470                 475         


<210>  87
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Thr Pro Glu Asp Pro Glu Glu Thr Gln Pro Ala Ala Gly Pro Pro 
1               5                   10                  15      


Gly Gly Ser Ala Pro Arg Gly Arg Arg Val Phe Leu Ala Ala Phe Ala 
            20                  25                  30          


Ala Ala Leu Gly Pro Leu Ser Phe Gly Phe Ala Leu Gly Tyr Ser Ser 
        35                  40                  45              


Pro Ala Ile Pro Ser Leu Gln Arg Ala Ala Pro Pro Ala Pro Arg Leu 
    50                  55                  60                  


Asp Asp Ala Ala Ala Ser Trp Phe Gly Ala Val Val Thr Leu Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Gly Val Leu Gly Gly Trp Leu Val Asp Arg Ala Gly Arg 
                85                  90                  95      


Lys Leu Ser Leu Leu Leu Cys Ser Val Pro Phe Val Ala Gly Phe Ala 
            100                 105                 110         


Val Ile Thr Ala Ala Gln Asp Val Trp Met Leu Leu Gly Gly Arg Leu 
        115                 120                 125             


Leu Thr Gly Leu Ala Cys Gly Val Ala Ser Leu Val Ala Pro Val Tyr 
    130                 135                 140                 


Ile Ser Glu Ile Ala Tyr Pro Ala Val Arg Gly Leu Leu Gly Ser Cys 
145                 150                 155                 160 


Val Gln Leu Met Val Val Val Gly Ile Leu Leu Ala Tyr Leu Ala Gly 
                165                 170                 175     


Trp Val Leu Glu Trp Arg Trp Leu Ala Val Leu Gly Cys Val Pro Pro 
            180                 185                 190         


Ser Leu Met Leu Leu Leu Met Cys Phe Met Pro Glu Thr Pro Arg Phe 
        195                 200                 205             


Leu Leu Thr Gln His Arg Arg Gln Glu Ala Met Ala Ala Leu Arg Phe 
    210                 215                 220                 


Leu Trp Gly Ser Glu Gln Gly Trp Glu Asp Pro Pro Ile Gly Ala Glu 
225                 230                 235                 240 


Gln Ser Phe His Leu Ala Leu Leu Arg Gln Pro Gly Ile Tyr Lys Pro 
                245                 250                 255     


Phe Ile Ile Gly Val Ser Leu Met Ala Phe Gln Gln Leu Ser Gly Val 
            260                 265                 270         


Asn Ala Val Met Phe Tyr Ala Glu Thr Ile Phe Glu Glu Ala Lys Phe 
        275                 280                 285             


Lys Asp Ser Ser Leu Ala Ser Val Val Val Gly Val Ile Gln Val Leu 
    290                 295                 300                 


Phe Thr Ala Val Ala Ala Leu Ile Met Asp Arg Ala Gly Arg Arg Leu 
305                 310                 315                 320 


Leu Leu Val Leu Ser Gly Val Val Met Val Phe Ser Thr Ser Ala Phe 
                325                 330                 335     


Gly Ala Tyr Phe Lys Leu Thr Gln Gly Gly Pro Gly Asn Ser Ser His 
            340                 345                 350         


Val Ala Ile Ser Ala Pro Val Ser Ala Gln Pro Val Asp Ala Ser Val 
        355                 360                 365             


Gly Leu Ala Trp Leu Ala Val Gly Ser Met Cys Leu Phe Ile Ala Gly 
    370                 375                 380                 


Phe Ala Val Gly Trp Gly Pro Ile Pro Trp Leu Leu Met Ser Glu Ile 
385                 390                 395                 400 


Phe Pro Leu His Val Lys Gly Val Ala Thr Gly Ile Cys Val Leu Thr 
                405                 410                 415     


Asn Trp Leu Met Ala Phe Leu Val Thr Lys Glu Phe Ser Ser Leu Met 
            420                 425                 430         


Glu Val Leu Arg Pro Tyr Gly Ala Phe Trp Leu Ala Ser Ala Phe Cys 
        435                 440                 445             


Ile Phe Ser Val Leu Phe Thr Leu Phe Cys Val Pro Glu Thr Lys Gly 
    450                 455                 460                 


Lys Thr Leu Glu Gln Ile Thr Ala His Phe Glu Gly Arg 
465                 470                 475         


<210>  88
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Arg Ala Leu Arg Arg Leu Ile Gln Gly Arg Ile Leu Leu Leu Thr 
1               5                   10                  15      


Ile Cys Ala Ala Gly Ile Gly Gly Thr Phe Gln Phe Gly Tyr Asn Leu 
            20                  25                  30          


Ser Ile Ile Asn Ala Pro Thr Leu His Ile Gln Glu Phe Thr Asn Glu 
        35                  40                  45              


Thr Trp Gln Ala Arg Thr Gly Glu Pro Leu Pro Asp His Leu Val Leu 
    50                  55                  60                  


Leu Met Trp Ser Leu Ile Val Ser Leu Tyr Pro Leu Gly Gly Leu Phe 
65                  70                  75                  80  


Gly Ala Leu Leu Ala Gly Pro Leu Ala Ile Thr Leu Gly Arg Lys Lys 
                85                  90                  95      


Ser Leu Leu Val Asn Asn Ile Phe Val Val Ser Ala Ala Ile Leu Phe 
            100                 105                 110         


Gly Phe Ser Arg Lys Ala Gly Ser Phe Glu Met Ile Met Leu Gly Arg 
        115                 120                 125             


Leu Leu Val Gly Val Asn Ala Gly Val Ser Met Asn Ile Gln Pro Met 
    130                 135                 140                 


Tyr Leu Gly Glu Ser Ala Pro Lys Glu Leu Arg Gly Ala Val Ala Met 
145                 150                 155                 160 


Ser Ser Ala Ile Phe Thr Ala Leu Gly Ile Val Met Gly Gln Val Val 
                165                 170                 175     


Gly Leu Arg Glu Leu Leu Gly Gly Pro Gln Ala Trp Pro Leu Leu Leu 
            180                 185                 190         


Ala Ser Cys Leu Val Pro Gly Ala Leu Gln Leu Ala Ser Leu Pro Leu 
        195                 200                 205             


Leu Pro Glu Ser Pro Arg Tyr Leu Leu Ile Asp Cys Gly Asp Thr Glu 
    210                 215                 220                 


Ala Cys Leu Ala Ala Leu Arg Arg Leu Arg Gly Ser Gly Asp Leu Ala 
225                 230                 235                 240 


Gly Glu Leu Glu Glu Leu Glu Glu Glu Arg Ala Ala Cys Gln Gly Cys 
                245                 250                 255     


Arg Ala Arg Arg Pro Trp Glu Leu Phe Gln His Arg Ala Leu Arg Arg 
            260                 265                 270         


Gln Val Thr Ser Leu Val Val Leu Gly Ser Ala Met Glu Leu Cys Gly 
        275                 280                 285             


Asn Asp Ser Val Tyr Ala Tyr Ala Ser Ser Val Phe Arg Lys Ala Gly 
    290                 295                 300                 


Val Pro Glu Ala Lys Ile Gln Tyr Ala Ile Ile Gly Thr Gly Ser Cys 
305                 310                 315                 320 


Glu Leu Leu Thr Ala Val Val Ser Cys Val Val Ile Glu Arg Val Gly 
                325                 330                 335     


Arg Arg Val Leu Leu Ile Gly Gly Tyr Ser Leu Met Thr Cys Trp Gly 
            340                 345                 350         


Ser Ile Phe Thr Val Ala Leu Cys Leu Gln Ser Ser Phe Pro Trp Thr 
        355                 360                 365             


Leu Tyr Leu Ala Met Ala Cys Ile Phe Ala Phe Ile Leu Ser Phe Gly 
    370                 375                 380                 


Ile Gly Pro Ala Gly Val Thr Gly Ile Leu Ala Thr Glu Leu Phe Asp 
385                 390                 395                 400 


Gln Met Ala Arg Pro Ala Ala Cys Met Val Cys Gly Ala Leu Met Trp 
                405                 410                 415     


Ile Met Leu Ile Leu Val Gly Leu Gly Phe Pro Phe Ile Met Glu Ala 
            420                 425                 430         


Leu Ser His Phe Leu Tyr Val Pro Phe Leu Gly Val Cys Val Cys Gly 
        435                 440                 445             


Ala Ile Tyr Thr Gly Leu Phe Leu Pro Glu Thr Lys Gly Lys Thr Phe 
    450                 455                 460                 


Gln Glu Ile Ser Lys Glu Leu His Arg Leu Asn Phe Pro Arg Arg Ala 
465                 470                 475                 480 


Gln Gly Pro Thr Trp Arg Ser Leu Glu Val Ile Gln Ser Thr Glu Leu 
                485                 490                 495     


<210>  89
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Glu Glu His Thr Glu Ala Gly Ser Ala Pro Glu Met Gly Ala Gln 
1               5                   10                  15      


Lys Ala Leu Ile Asp Asn Pro Ala Asp Ile Leu Val Ile Ala Ala Tyr 
            20                  25                  30          


Phe Leu Leu Val Ile Gly Val Gly Leu Trp Ser Met Cys Arg Thr Asn 
        35                  40                  45              


Arg Gly Thr Val Gly Gly Tyr Phe Leu Ala Gly Arg Ser Met Val Trp 
    50                  55                  60                  


Trp Pro Val Gly Ala Ser Leu Phe Ala Ser Asn Ile Gly Ser Gly His 
65                  70                  75                  80  


Phe Val Gly Leu Ala Gly Thr Gly Ala Ala Ser Gly Leu Ala Val Ala 
                85                  90                  95      


Gly Phe Glu Trp Asn Ala Leu Phe Val Val Leu Leu Leu Gly Trp Leu 
            100                 105                 110         


Phe Ala Pro Val Tyr Leu Thr Ala Gly Val Ile Thr Met Pro Gln Tyr 
        115                 120                 125             


Leu Arg Lys Arg Phe Gly Gly Arg Arg Ile Arg Leu Tyr Leu Ser Val 
    130                 135                 140                 


Leu Ser Leu Phe Leu Tyr Ile Phe Thr Lys Ile Ser Val Asp Met Phe 
145                 150                 155                 160 


Ser Gly Ala Val Phe Ile Gln Gln Ala Leu Gly Trp Asn Ile Tyr Ala 
                165                 170                 175     


Ser Val Ile Ala Leu Leu Gly Ile Thr Met Ile Tyr Thr Val Thr Gly 
            180                 185                 190         


Gly Leu Ala Ala Leu Met Tyr Thr Asp Thr Val Gln Thr Phe Val Ile 
        195                 200                 205             


Leu Gly Gly Ala Cys Ile Leu Met Gly Tyr Ala Phe His Glu Val Gly 
    210                 215                 220                 


Gly Tyr Ser Gly Leu Phe Asp Lys Tyr Leu Gly Ala Ala Thr Ser Leu 
225                 230                 235                 240 


Thr Val Ser Glu Asp Pro Ala Val Gly Asn Ile Ser Ser Phe Cys Tyr 
                245                 250                 255     


Arg Pro Arg Pro Asp Ser Tyr His Leu Leu Arg His Pro Val Thr Gly 
            260                 265                 270         


Asp Leu Pro Trp Pro Ala Leu Leu Leu Gly Leu Thr Ile Val Ser Gly 
        275                 280                 285             


Trp Tyr Trp Cys Ser Asp Gln Val Ile Val Gln Arg Cys Leu Ala Gly 
    290                 295                 300                 


Lys Ser Leu Thr His Ile Lys Ala Gly Cys Ile Leu Cys Gly Tyr Leu 
305                 310                 315                 320 


Lys Leu Thr Pro Met Phe Leu Met Val Met Pro Gly Met Ile Ser Arg 
                325                 330                 335     


Ile Leu Tyr Pro Asp Glu Val Ala Cys Val Val Pro Glu Val Cys Arg 
            340                 345                 350         


Arg Val Cys Gly Thr Glu Val Gly Cys Ser Asn Ile Ala Tyr Pro Arg 
        355                 360                 365             


Leu Val Val Lys Leu Met Pro Asn Gly Leu Arg Gly Leu Met Leu Ala 
    370                 375                 380                 


Val Met Leu Ala Ala Leu Met Ser Ser Leu Ala Ser Ile Phe Asn Ser 
385                 390                 395                 400 


Ser Ser Thr Leu Phe Thr Met Asp Ile Tyr Thr Arg Leu Arg Pro Arg 
                405                 410                 415     


Ala Gly Asp Arg Glu Leu Leu Leu Val Gly Arg Leu Trp Val Val Phe 
            420                 425                 430         


Ile Val Val Val Ser Val Ala Trp Leu Pro Val Val Gln Ala Ala Gln 
        435                 440                 445             


Gly Gly Gln Leu Phe Asp Tyr Ile Gln Ala Val Ser Ser Tyr Leu Ala 
    450                 455                 460                 


Pro Pro Val Ser Ala Val Phe Val Leu Ala Leu Phe Val Pro Arg Val 
465                 470                 475                 480 


Asn Glu Gln Gly Ala Phe Trp Gly Leu Ile Gly Gly Leu Leu Met Gly 
                485                 490                 495     


Leu Ala Arg Leu Ile Pro Glu Phe Ser Phe Gly Ser Gly Ser Cys Val 
            500                 505                 510         


Gln Pro Ser Ala Cys Pro Ala Phe Leu Cys Gly Val His Tyr Leu Tyr 
        515                 520                 525             


Phe Ala Ile Val Leu Phe Phe Cys Ser Gly Leu Leu Thr Leu Thr Val 
    530                 535                 540                 


Ser Leu Cys Thr Ala Pro Ile Pro Arg Lys His Leu His Arg Leu Val 
545                 550                 555                 560 


Phe Ser Leu Arg His Ser Lys Glu Glu Arg Glu Asp Leu Asp Ala Asp 
                565                 570                 575     


Glu Gln Gln Gly Ser Ser Leu Pro Val Gln Asn Gly Cys Pro Glu Ser 
            580                 585                 590         


Ala Met Glu Met Asn Glu Pro Gln Ala Pro Ala Pro Ser Leu Phe Arg 
        595                 600                 605             


Gln Cys Leu Leu Trp Phe Cys Gly Met Ser Arg Gly Gly Val Gly Ser 
    610                 615                 620                 


Pro Pro Pro Leu Thr Gln Glu Glu Ala Ala Ala Ala Ala Arg Arg Leu 
625                 630                 635                 640 


Glu Asp Ile Ser Glu Asp Pro Ser Trp Ala Arg Val Val Asn Leu Asn 
                645                 650                 655     


Ala Leu Leu Met Met Ala Val Ala Val Phe Leu Trp Gly Phe Tyr Ala 
            660                 665                 670         


<210>  90
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


<210>  91
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  92
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  92

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        195                 200                 205             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300 


<210>  93
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  93

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  94
<211>  664
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  94

Met Asp Ser Ser Thr Trp Ser Pro Lys Thr Thr Ala Val Thr Arg Pro 
1               5                   10                  15      


Val Glu Thr His Glu Leu Ile Arg Asn Ala Ala Asp Ile Ser Ile Ile 
            20                  25                  30          


Val Ile Tyr Phe Val Val Val Met Ala Val Gly Leu Trp Ala Met Phe 
        35                  40                  45              


Ser Thr Asn Arg Gly Thr Val Gly Gly Phe Phe Leu Ala Gly Arg Ser 
    50                  55                  60                  


Met Val Trp Trp Pro Ile Gly Ala Ser Leu Phe Ala Ser Asn Ile Gly 
65                  70                  75                  80  


Ser Gly His Phe Val Gly Leu Ala Gly Thr Gly Ala Ala Ser Gly Ile 
                85                  90                  95      


Ala Ile Gly Gly Phe Glu Trp Asn Ala Leu Val Leu Val Val Val Leu 
            100                 105                 110         


Gly Trp Leu Phe Val Pro Ile Tyr Ile Lys Ala Gly Val Val Thr Met 
        115                 120                 125             


Pro Glu Tyr Leu Arg Lys Arg Phe Gly Gly Gln Arg Ile Gln Val Tyr 
    130                 135                 140                 


Leu Ser Leu Leu Ser Leu Leu Leu Tyr Ile Phe Thr Lys Ile Ser Ala 
145                 150                 155                 160 


Asp Ile Phe Ser Gly Ala Ile Phe Ile Asn Leu Ala Leu Gly Leu Asn 
                165                 170                 175     


Leu Tyr Leu Ala Ile Phe Leu Leu Leu Ala Ile Thr Ala Leu Tyr Thr 
            180                 185                 190         


Ile Thr Gly Gly Leu Ala Ala Val Ile Tyr Thr Asp Thr Leu Gln Thr 
        195                 200                 205             


Val Ile Met Leu Val Gly Ser Leu Ile Leu Thr Gly Phe Ala Phe His 
    210                 215                 220                 


Glu Val Gly Gly Tyr Asp Ala Phe Met Glu Lys Tyr Met Lys Ala Ile 
225                 230                 235                 240 


Pro Thr Ile Val Ser Asp Gly Asn Thr Thr Phe Gln Glu Lys Cys Tyr 
                245                 250                 255     


Thr Pro Arg Ala Asp Ser Phe His Ile Phe Arg Asp Pro Leu Thr Gly 
            260                 265                 270         


Asp Leu Pro Trp Pro Gly Phe Ile Phe Gly Met Ser Ile Leu Thr Leu 
        275                 280                 285             


Trp Tyr Trp Cys Thr Asp Gln Val Ile Val Gln Arg Cys Leu Ser Ala 
    290                 295                 300                 


Lys Asn Met Ser His Val Lys Gly Gly Cys Ile Leu Cys Gly Tyr Leu 
305                 310                 315                 320 


Lys Leu Met Pro Met Phe Ile Met Val Met Pro Gly Met Ile Ser Arg 
                325                 330                 335     


Ile Leu Tyr Thr Glu Lys Ile Ala Cys Val Val Pro Ser Glu Cys Glu 
            340                 345                 350         


Lys Tyr Cys Gly Thr Lys Val Gly Cys Thr Asn Ile Ala Tyr Pro Thr 
        355                 360                 365             


Leu Val Val Glu Leu Met Pro Asn Gly Leu Arg Gly Leu Met Leu Ser 
    370                 375                 380                 


Val Met Leu Ala Ser Leu Met Ser Ser Leu Thr Ser Ile Phe Asn Ser 
385                 390                 395                 400 


Ala Ser Thr Leu Phe Thr Met Asp Ile Tyr Ala Lys Val Arg Lys Arg 
                405                 410                 415     


Ala Ser Glu Lys Glu Leu Met Ile Ala Gly Arg Leu Phe Ile Leu Val 
            420                 425                 430         


Leu Ile Gly Ile Ser Ile Ala Trp Val Pro Ile Val Gln Ser Ala Gln 
        435                 440                 445             


Ser Gly Gln Leu Phe Asp Tyr Ile Gln Ser Ile Thr Ser Tyr Leu Gly 
    450                 455                 460                 


Pro Pro Ile Ala Ala Val Phe Leu Leu Ala Ile Phe Trp Lys Arg Val 
465                 470                 475                 480 


Asn Glu Pro Gly Ala Phe Trp Gly Leu Ile Leu Gly Leu Leu Ile Gly 
                485                 490                 495     


Ile Ser Arg Met Ile Thr Glu Phe Ala Tyr Gly Thr Gly Ser Cys Met 
            500                 505                 510         


Glu Pro Ser Asn Cys Pro Thr Ile Ile Cys Gly Val His Tyr Leu Tyr 
        515                 520                 525             


Phe Ala Ile Ile Leu Phe Ala Ile Ser Phe Ile Thr Ile Val Val Ile 
    530                 535                 540                 


Ser Leu Leu Thr Lys Pro Ile Pro Asp Val His Leu Tyr Arg Leu Cys 
545                 550                 555                 560 


Trp Ser Leu Arg Asn Ser Lys Glu Glu Arg Ile Asp Leu Asp Ala Glu 
                565                 570                 575     


Glu Glu Asn Ile Gln Glu Gly Pro Lys Glu Thr Ile Glu Ile Glu Thr 
            580                 585                 590         


Gln Val Pro Glu Lys Lys Lys Gly Ile Phe Arg Arg Ala Tyr Asp Leu 
        595                 600                 605             


Phe Cys Gly Leu Glu Gln His Gly Ala Pro Lys Met Thr Glu Glu Glu 
    610                 615                 620                 


Glu Lys Ala Met Lys Met Lys Met Thr Asp Thr Ser Glu Lys Pro Leu 
625                 630                 635                 640 


Trp Arg Thr Val Leu Asn Val Asn Gly Ile Ile Leu Val Thr Val Ala 
                645                 650                 655     


Val Phe Cys His Ala Tyr Phe Ala 
            660                 


<210>  95
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  95

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  


<210>  96
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  96

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45  


<210>  97
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  97

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55                  60  


<210>  98
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  98

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75  


<210>  99
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  99

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser 
145                 150 


<210>  100
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  100

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        195                 200                 205             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser 
225 


<210>  101
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  101

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        195                 200                 205             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300 


<210>  102
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  102

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  103
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  103

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly 
        


<210>  104
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  104

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Arg Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Glu Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala 
        195                 200                 205             


Tyr Ser Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Ala Asp Lys Ser 
    210                 215                 220                 


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  105
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  105

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Arg Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Glu Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala 
        195                 200                 205             


Tyr Ser Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Ala Asp Lys Ser 
    210                 215                 220                 


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro 
            260                 265                 270         


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
        275                 280                 285             


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
    290                 295                 300                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
305                 310                 315                 320 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                325                 330                 335     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


