                               SEQUENCE LISTING

<110> VOYAGER THERAPEUTICS, INC.
 
<120> TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND DISORDERS 
      ASSOCIATED WITH THE SPINAL CORD

<130> 2057.1070PCT

<140> PCT/US2019/XXXXXX
<141> 2019-07-02

<150> 62/746,104
<151> 2018-10-16

<150> 62/693,040
<151> 2018-07-02

<160> 30    

<170> PatentIn version 3.5

<210> 1
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 1
uauuaaagug aggaccugcu u                                                 21


<210> 2
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide "

<400> 2
gcagguccuc acuuuaaugc u                                                 21


<210> 3
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 3
ctcccgcaga acaccatgcg ctccacggaa                                        30


<210> 4
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 4
gtggccactg agaag                                                        15


<210> 5
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 5
ctgaggagcg ccttgacagc agccatggga gggcc                                  35


<210> 6
<211> 122
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 6
ctcccgcaga acaccatgcg ctccacggaa gcaggtcctc actttaatgc tgtggccact       60

gagaagtatt aaagtgagga cctgcttctg aggagcgcct tgacagcagc catgggaggg      120

cc                                                                     122


<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 7
gcaggtcctc actttaatgc t                                                 21


<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 8
tattaaagtg aggacctgct t                                                 21


<210> 9
<211> 1406
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 9
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtgtagcc atgctctagg      120

aagatcaatt caattcacgc gtccatggct tagaaggcaa gaatcctggc tgtggaaaga      180

tacctaaagg atcaacagct cctggggatt tggggttgct ctggaaaact catttgcacc      240

actgctgtgc cttggaatgc tagttggagt aataaatctc tggaacagat ttggaatcac      300

acgacctgga tggagtggga cagagaaatt aacaattaca caagcttaat acactcctta      360

attgaagaat cgcaaaacca gcaagaaaag aatgaacaag aattattgga attagataaa      420

tgggcaagtt tgtggaattg gtttaacata acaaattggc tgtggtatat aaaattattc      480

ataatgatag taggaggctt ggtaggttta agaatagttt ttgctgtact ttctatagtg      540

aatagagtta ggcagggata ttcaccatta tcgtttcaga cccacctccc aaccccgagg      600

ggacccgaca ggcccgaagg aatagaagaa gaaggtggag agagagacag agacagatcc      660

attcgattag tgaacggatc tcgacggtat cgatcacgag actagcctcg agcggccgca      720

attcgaacgc tgacgtcatc aacccgctcc aaggaatcgc gggcccagtg tcactaggcg      780

ggaacaccca gcgcgcgtgc gccctggcag gaagatggct gtgagggaca gggagtggcg      840

ccctgcaata tttgcatgtc gctatgtgtt ctgggaaatc accataaacg tgaaatgtct      900

ttggatttgg gaatcttata agttctgtat gagaccacac cggtaccgag ctctcccgca      960

gaacaccatg cgctccacgg aagcaggtcc tcactttaat gctgtggcca ctgagaagta     1020

ttaaagtgag gacctgcttc tgaggagcgc cttgacagca gccatgggag ggcctcgagg     1080

acggggtgaa ctacgcctga ggatccgatc tttttccctc tgccaaaaat tatggggaca     1140

tcatgaagcc ccttgagcat ctgacttctg gctaataaag gaaatttatt ttcattgcaa     1200

tagtgtgttg gaattttttg tgtctctcac tcggcctagg tagataagta gcatggcggg     1260

ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct     1320

cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg     1380

gcctcagtga gcgagcgagc gcgcag                                          1406


<210> 10
<211> 981
<212> DNA
<213> Homo sapiens

<400> 10
gtttggggcc agagtgggcg aggcgcggag gtctggccta taaagtagtc gcggagacgg       60

ggtgctggtt tgcgtcgtag tctcctgcag cgtctggggt ttccgttgca gtcctcggaa      120

ccaggacctc ggcgtggcct agcgagttat ggcgacgaag gccgtgtgcg tgctgaaggg      180

cgacggccca gtgcagggca tcatcaattt cgagcagaag gaaagtaatg gaccagtgaa      240

ggtgtgggga agcattaaag gactgactga aggcctgcat ggattccatg ttcatgagtt      300

tggagataat acagcaggct gtaccagtgc aggtcctcac tttaatcctc tatccagaaa      360

acacggtggg ccaaaggatg aagagaggca tgttggagac ttgggcaatg tgactgctga      420

caaagatggt gtggccgatg tgtctattga agattctgtg atctcactct caggagacca      480

ttgcatcatt ggccgcacac tggtggtcca tgaaaaagca gatgacttgg gcaaaggtgg      540

aaatgaagaa agtacaaaga caggaaacgc tggaagtcgt ttggcttgtg gtgtaattgg      600

gatcgcccaa taaacattcc cttggatgta gtctgaggcc ccttaactca tctgttatcc      660

tgctagctgt agaaatgtat cctgataaac attaaacact gtaatcttaa aagtgtaatt      720

gtgtgacttt ttcagagttg ctttaaagta cctgtagtga gaaactgatt tatgatcact      780

tggaagattt gtatagtttt ataaaactca gttaaaatgt ctgtttcaat gacctgtatt      840

ttgccagact taaatcacag atgggtatta aacttgtcag aatttctttg tcattcaagc      900

ctgtgaataa aaaccctgta tggcacttat tatgaggcta ttaaaagaat ccaaattcaa      960

actaaaaaaa aaaaaaaaaa a                                                981


<210> 11
<211> 465
<212> DNA
<213> Macaca sp.

<400> 11
atggcgatga aggccgtgtg cgtgttgaag ggcgacagcc cagtgcaggg caccatcaat       60

ttcgagcaga aggaaagtaa tggaccagtg aaggtgtggg gaagcattac aggattgact      120

gaaggcctgc atggattcca tgttcatcag tttggagata atacacaagg ctgtaccagt      180

gcaggtcctc actttaatcc tctatccaga caacacggtg ggccaaagga tgaagagagg      240

catgttggag acctgggcaa tgtgactgct ggcaaagatg gtgtggccaa ggtgtctttc      300

gaagattctg tgatctcgct ctcaggagac cattccatca ttggccgcac attggtggtc      360

catgaaaaag cagatgactt gggcaaaggt ggaaatgaag aaagtaaaaa gacaggaaac      420

gctggaggtc gtctggcttg tggtgtaatt gggatcgccc aataa                      465


<210> 12
<211> 658
<212> DNA
<213> Sus scrofa

<400> 12
cgtcggcgtg tactgcggcc tctcccgctg cttctggtac cctcccagcc cggaccggag       60

cgcgcccccg cgagtcatgg cgacgaaggc cgtgtgtgtg ctgaagggcg acggcccggt      120

gcagggcacc atctacttcg agctgaaggg agagaagaca gtgttagtaa cgggaaccat      180

taaaggactg gctgaaggtg atcatggatt ccatgtccat cagtttggag ataatacaca      240

aggctgtacc agtgcaggtc ctcacttcaa tcctgaatcc aaaaaacatg gtgggccaaa      300

ggatcaagag aggcacgttg gagacctggg caatgtgact gctggcaaag atggtgtggc      360

cactgtgtac atcgaagatt ctgtgatcgc cctctcggga gaccattcca tcattggccg      420

cacaatggtg gtccatgaaa aaccagatga cttgggcaga ggtggaaatg aagaaagtac      480

aaagacggga aatgctggaa gtcgtttggc ctgtggtgta attgggatca cccagtaaac      540

attccctcat gccatggtct gaatgccagt aactcatctg ttatcttgct agttgtagtt      600

gtagaaattt aacttgataa acattaaaca ctgtaacctt aaaaaaaaaa aaaaaaaa        658


<210> 13
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 13
gtgctgggcg gggggcggcg ggccctcccg cagaacacca tgcgctcttc ggaa             54


<210> 14
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 14
gtgctgggcg gggggcggcg ggccctcccg cagaacacca tgcgctccac ggaa             54


<210> 15
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 15
tgtgatttgg                                                              10


<210> 16
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 16
gtggccactg agaag                                                        15


<210> 17
<211> 100
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 17
tggccgtgta gtgctaccca gcgctggctg cctcctcagc attgcaattc ctctcccatc       60

tgggcaccag tcagctaccc tggtgggaat ctgggtagcc                            100


<210> 18
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 18
ctgtggagcg ccttgacagc agccatggga gggccgcccc ctacctcagt ga               52


<210> 19
<211> 260
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 19
gaagcaaaga aggggcagag ggagcccgtg agctgagtgg gccagggact gggagaagga       60

gtgaggaggc agggccggca tgcctctgct gctggccaga ccccttaact catttgttcc      120

cgtctgcacc tgtcactagt aacagatgag ttaaggggtt tggccgtgta gtgctaccca      180

gcgctggctg cctcctcagc attgcaattc ctctcccatc tgggcaccag tcagctaccc      240

tggtgggaat ctgggtagcc                                                  260


<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 20
ccccttaact catttgttcc c                                                 21


<210> 21
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 21
taacagatga gttaaggggt t                                                 21


<210> 22
<211> 158
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 22
gtgctgggcg gggggcggcg ggccctcccg cagaacacca tgcgctcttc ggaaccctta       60

actgatctgt taacctgtga cctggttaac agatgagtta agggttctgt ggagcgcctt      120

gacagcagcc atgggagggc cgccccctac ctcagtga                              158


<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 23
cccttaactg atctgttaac c                                                 21


<210> 24
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 24
ttaacagatg agttaagggt t                                                 21


<210> 25
<211> 1412
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 25
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtgtagcc atgctctagg      120

aagatcaatt caattcacgc gtatagtctt ctgcacaggg cattcttttt gcttcaggat      180

gtttacaaca tttgctgccc acttttccta ggtttcttga gacctctaca agagttggag      240

ttgacacttg gggtactttc ttggtgtaac gaactaatag cctgaaaaaa agaagtcatg      300

tgttttcagc aaggcaagaa actgtctaac atagtagata aaacagagaa cacttggccg      360

gaatcaacta agatgttgct atgttccatt catcatatta tctccatctg cagagtagtg      420

ggttagtgga gggtagaaaa cattctcctg aacaactagt taaacttggc tttgagttcc      480

acctgtacca cttgcataat cttgggaaag tgagttgcct aattcagtga cattaataaa      540

tttattaatt tcttctttca ataaaacctg gagagagctt catatgtatc agcatatgct      600

aaacttgaaa gatacaagta gaaaatggaa ggaaatatat ctgactcaat agggatagtt      660

caagggttaa attaaaagta gtaaagtatt ataattaatc tgacatggta ccctctagcg      720

gccgcaattc gaacgctgac gtcatcaacc cgctccaagg aatcgcgggc ccagtgtcac      780

taggcgggaa cacccagcgc gcgtgcgccc tggcaggaag atggctgtga gggacaggga      840

gtggcgccct gcaatatttg catgtcgcta tgtgttctgg gaaatcacca taaacgtgaa      900

atgtctttgg atttgggaat cttataagtt ctgtatgaga ccacaccggt accgagctct      960

cccgcagaac accatgcgct ccacggaagc aggtcctcac tttaatgctg tggccactga     1020

gaagtattaa agtgaggacc tgcttctgag gagcgccttg acagcagcca tgggagggcc     1080

tcgaggacgg ggtgaactac gcctgaggat ccgatctttt tccctctgcc aaaaattatg     1140

gggacatcat gaagcccctt gagcatctga cttctggcta ataaaggaaa tttattttca     1200

ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg cctaggtaga taagtagcat     1260

ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg     1320

cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc     1380

cgggcggcct cagtgagcga gcgagcgcgc ag                                   1412


<210> 26
<211> 105
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 26
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtg                      105


<210> 27
<211> 570
<212> DNA
<213> Homo sapiens

<400> 27
atagtcttct gcacagggca ttctttttgc ttcaggatgt ttacaacatt tgctgcccac       60

ttttcctagg tttcttgaga cctctacaag agttggagtt gacacttggg gtactttctt      120

ggtgtaacga actaatagcc tgaaaaaaag aagtcatgtg ttttcagcaa ggcaagaaac      180

tgtctaacat agtagataaa acagagaaca cttggccgga atcaactaag atgttgctat      240

gttccattca tcatattatc tccatctgca gagtagtggg ttagtggagg gtagaaaaca      300

ttctcctgaa caactagtta aacttggctt tgagttccac ctgtaccact tgcataatct      360

tgggaaagtg agttgcctaa ttcagtgaca ttaataaatt tattaatttc ttctttcaat      420

aaaacctgga gagagcttca tatgtatcag catatgctaa acttgaaaga tacaagtaga      480

aaatggaagg aaatatatct gactcaatag ggatagttca agggttaaat taaaagtagt      540

aaagtattat aattaatctg acatggtacc                                       570


<210> 28
<211> 219
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 28
aattcgaacg ctgacgtcat caacccgctc caaggaatcg cgggcccagt gtcactaggc       60

gggaacaccc agcgcgcgtg cgccctggca ggaagatggc tgtgagggac agggagtggc      120

gccctgcaat atttgcatgt cgctatgtgt tctgggaaat caccataaac gtgaaatgtc      180

tttggatttg ggaatcttat aagttctgta tgagaccac                             219


<210> 29
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 29
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcg                                                                127


<210> 30
<211> 130
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polynucleotide"

<400> 30
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


