                         SEQUENCE LISTING

<110>  Development Center for Biotechnology
       DCB-USA LLC
 
<120>  ANTI-HUMAN TIM-3 ANTIBODIES AND METHODS OF USE THEREOF

<130>  DCB8.2-797PCT

<150>  US 62/691,793
<151>  2018-06-29

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asn Pro Ser Asn Gly Gly Thr Asn Asn Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Leu Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Ser Ser Gly Tyr Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  2
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ile Leu Ile 
        35                  40                  45              


Phe Ser Pro Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Asn Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg Arg 
            100                 105             


<210>  3
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  3

Gly Tyr Thr Phe Thr Asp Tyr Tyr Met Asn 
1               5                   10  


<210>  4
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  4

Arg Val Asn Pro Ser Asn Gly Gly Thr Asn Asn Asn Gln Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  5

Arg Asp Ser Ser Gly Tyr Trp Phe Ala Tyr 
1               5                   10  


<210>  6
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  6

Lys Ala Ser Gln Asp Val Ser Thr Ala Val Val 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  7

Ser Pro Ser Tyr Arg Tyr Thr 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Gln His Tyr Asn Ile Pro Trp Thr 
1               5                   


<210>  9
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Pro Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln His Tyr Asn Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  10
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Val Asn Pro Ser Asn Gly Gly Thr Asn Asn Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Ser Ser Gly Tyr Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  11
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  11

Arg Lys Gly Asp Val Ser Leu 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  12

Glu Lys Phe Asn Leu Lys Leu 
1               5           


<210>  13
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Pro Ser Tyr Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Asn Ile Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  14
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Arg Val Asn Pro Ser Asn Gly Gly Thr Asn Asn Asn 
65                  70                  75                  80  


Gln Asn Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ser Ser Gly Tyr Trp Phe Ala Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly 
465         


<210>  15
<211>  380
<212>  DNA
<213>  Homo sapiens

<400>  15
tacgcgtgtc ctgtcccaag ttcagctggt tcagtctggc gccgaagtga agaaacctgg       60

cgcctctgtg aaggtgtcct gcaaggccag cggctacacc tttaccgact actacatgaa      120

ctgggtccga caggcccctg gacagggact tgaatggatg ggcagagtga accccagcaa      180

cggcggcacc aacaacaacc agaacttcaa gggaagagtg accatgacca gagacaccag      240

catcagcacc gcctacatgg aactgagccg gctgagatcc gatgacaccg ccgtgtacta      300

ctgcgccaga agagacagca gcggctattg gttcgcctat tggggccagg gcacactggt      360

cacagttagc tctgctagca                                                  380


<210>  16
<211>  380
<212>  DNA
<213>  Homo sapiens

<400>  16
tacgcgtgtc ctgtcccaag ttcagctggt tcagtctggc gccgaagtga agaaacctgg       60

cgcctctgtg aaggtgtcct gcaaggccag cggctacacc tttaccgact actacatgaa      120

ctgggtcaag caggcccctg gacagggact cgagtggatc ggaagagtga accctagcaa      180

cggcggcacc aacaacaacc agaacttcaa gggcaaagcc acactgaccg tggacaagag      240

catcaacacc gcctacatgg aactgagccg gctgagatcc gatgacaccg ccgtgtacta      300

ctgcgccaga agagacagca gcggctattg gttcgcctat tggggccagg gcacactggt      360

cacagttagc tctgctagca                                                  380


<210>  17
<211>  380
<212>  DNA
<213>  Homo sapiens

<400>  17
tacgcgtgtc ctgtcccaag ttcagctggt tcagtctggc gccgaagtga agaaacctgg       60

cgcctctgtg aaggtgtcct gcaaggccag cggctacacc tttaccgact actacatgaa      120

ctgggtccga caggcccctg gacagggact tgaatggatg ggcagagtga accccagcaa      180

cggcggcacc aacaacaacc agaacttcaa gggaagagtg accctgaccg tggacaagag      240

catcaacacc gcctacatgg aactgagccg gctgagatcc gatgacaccg ccgtgtacta      300

ctgcgccaga agagacagca gcggctattg gttcgcctat tggggccagg gcacactggt      360

cacagttagc tctgctagca                                                  380


<210>  18
<211>  340
<212>  DNA
<213>  Homo sapiens

<400>  18
ggtgcacgat gtgacattgt gatgacacag agccccgaca gcctggccgt gtctcttgga       60

gaaagagcca ccatcaactg caaggccagc caggatgtgt ctaccgccgt cgtgtggtat      120

cagcagaagc ctggacagcc tcctaagctg ctgatctaca gccccagcta cagatacacc      180

ggcgtgcccg atagattttc cggctctggc agcggcaccg acttcaccct tacaatcagt      240

tccctgcagg ccgaggacgt ggccgtgtac tattgtcagc agcactacaa catcccttgg      300

accttcggcc agggcaccaa ggtggaaatc aagcgtacgg                            340


<210>  19
<211>  340
<212>  DNA
<213>  Homo sapiens

<400>  19
ggtgcacgat gtgatatcgt gatgacacag agccccgaca gcctggccgt gtctcttgga       60

gaaagagcca ccatcaactg caaggccagc caggatgtgt ctaccgccgt cgtgtggtat      120

cagcagaagc ctggacagcc tcctaagatc ctgatcttca gccccagcta ccggtacacc      180

ggcgtgccag atagattttc tggcagcggc tccggcaccg acttcaccct tacaattagc      240

tccctgcagg ccgaggacgt ggccgtgtat tattgccagc agcactacaa catcccttgg      300

acctttggcc agggcaccaa ggtggaaatc aagcgtacgg                            340


<210>  20
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asn Pro Ser Asn Gly Gly Thr Asn Asn Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Ser Ser Gly Tyr Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  21
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Val Asn Pro Ser Asn Gly Gly Thr Asn Asn Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Ser Ser Gly Tyr Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  22
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Ile Leu Ile 
        35                  40                  45              


Phe Ser Pro Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln His Tyr Asn Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


