                               SEQUENCE LISTING

<110> VERSEAU THERAPEUTICS, INC.
 
<120> COMPOSITIONS AND METHODS FOR MODULATING MONOCYTE AND MACROPHAGE 
      INFLAMMATORY PHENOTYPES AND IMMUNOTHERAPY USES THEREOF

<130> VTC-00425

<140> PCT/US2019/039773
<141> 2019-06-28

<150> 62/867,532
<151> 2019-06-27

<150> 62/857,199
<151> 2019-06-04

<150> 62/810,683
<151> 2019-02-26

<150> 62/692,463
<151> 2018-06-29

<160> 730   

<170> PatentIn version 3.5

<210> 1
<211> 1600
<212> DNA
<213> Homo sapiens

<400> 1
tagggcctcc tctaagtctt gagcccgcag ttcctgagag aagaaccctg aggaacagac       60

gttccctcgc ggccctggca cctctaaccc cagacatgct gctgctgctg ctgcccctgc      120

tctgggggag ggagagggcg gaaggacaga caagtaaact gctgacgatg cagagttccg      180

tgacggtgca ggaaggcctg tgtgtccatg tgccctgctc cttctcctac ccctcgcatg      240

gctggattta ccctggccca gtagttcatg gctactggtt ccgggaaggg gccaatacag      300

accaggatgc tccagtggcc acaaacaacc cagctcgggc agtgtgggag gagactcggg      360

accgattcca cctccttggg gacccacata ccaagaattg caccctgagc atcagagatg      420

ccagaagaag tgatgcgggg agatacttct ttcgtatgga gaaaggaagt ataaaatgga      480

attataaaca tcaccggctc tctgtgaatg tgacagcctt gacccacagg cccaacatcc      540

tcatcccagg caccctggag tccggctgcc cccagaatct gacctgctct gtgccctggg      600

cctgtgagca ggggacaccc cctatgatct cctggatagg gacctccgtg tcccccctgg      660

acccctccac cacccgctcc tcggtgctca ccctcatccc acagccccag gaccatggca      720

ccagcctcac ctgtcaggtg accttccctg gggccagcgt gaccacgaac aagaccgtcc      780

atctcaacgt gtcctacccg cctcagaact tgaccatgac tgtcttccaa ggagacggca      840

cagtatccac agtcttggga aatggctcat ctctgtcact cccagagggc cagtctctgc      900

gcctggtctg tgcagttgat gcagttgaca gcaatccccc tgccaggctg agcctgagct      960

ggagaggcct gaccctgtgc ccctcacagc cctcaaaccc gggggtgctg gagctgcctt     1020

gggtgcacct gagggatgca gctgaattca cctgcagagc tcagaaccct ctcggctctc     1080

agcaggtcta cctgaacgtc tccctgcaga gcaaagccac atcaggagtg actcaggggg     1140

tggtcggggg agctggagcc acagccctgg tcttcctgtc cttctgcgtc atcttcgttg     1200

tagtgaggtc ctgcaggaag aaatcggcaa ggccagcagc gggcgtggga gatacgggca     1260

tagaggatgc aaacgctgtc aggggttcag cctctcagat cttgaatcat tttattggat     1320

ttcctacatt ccttggactg ggtttcgagt ttctcctgaa tctccgtgat ctttgttgcc     1380

atccagattc tgaattctat gtctatcatt tcagtcattt cagactcatt aagaacattg     1440

ctggggagat agtgtggtca cttgaaggta aaatactctg gcttttggat gtgtcagatt     1500

tctttcactg gttcttcctc atctgtgtgg gctgatgttc ctttaatctt tgaagttgct     1560

gttctttgga tagggctctt tgcttttata ttctctgatg                           1600


<210> 2
<211> 479
<212> PRT
<213> Homo sapiens

<400> 2
Met Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala Glu 
1               5                   10                  15      


Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 
    50                  55                  60                  


Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 
65                  70                  75                  80  


Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 
                85                  90                  95      


Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 
            100                 105                 110         


Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 
        115                 120                 125             


Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 
    130                 135                 140                 


Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 
145                 150                 155                 160 


Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 
                165                 170                 175     


Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 
            180                 185                 190         


Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 
        195                 200                 205             


Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 
    210                 215                 220                 


Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 
225                 230                 235                 240 


Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 
                245                 250                 255     


Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 
            260                 265                 270         


Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 
        275                 280                 285             


Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 
    290                 295                 300                 


Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 
305                 310                 315                 320 


Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 
                325                 330                 335     


Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Val Val Gly Gly 
            340                 345                 350         


Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys Val Ile Phe Val 
        355                 360                 365             


Val Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly Val 
    370                 375                 380                 


Gly Asp Thr Gly Ile Glu Asp Ala Asn Ala Val Arg Gly Ser Ala Ser 
385                 390                 395                 400 


Gln Ile Leu Asn His Phe Ile Gly Phe Pro Thr Phe Leu Gly Leu Gly 
                405                 410                 415     


Phe Glu Phe Leu Leu Asn Leu Arg Asp Leu Cys Cys His Pro Asp Ser 
            420                 425                 430         


Glu Phe Tyr Val Tyr His Phe Ser His Phe Arg Leu Ile Lys Asn Ile 
        435                 440                 445             


Ala Gly Glu Ile Val Trp Ser Leu Glu Gly Lys Ile Leu Trp Leu Leu 
    450                 455                 460                 


Asp Val Ser Asp Phe Phe His Trp Phe Phe Leu Ile Cys Val Gly 
465                 470                 475                 


<210> 3
<211> 1737
<212> DNA
<213> Homo sapiens

<400> 3
tagggcctcc tctaagtctt gagcccgcag ttcctgagag aagaaccctg aggaacagac       60

gttccctcgc ggccctggca cctctaaccc cagacatgct gctgctgctg ctgcccctgc      120

tctgggggag ggagagggcg gaaggacaga caagtaaact gctgacgatg cagagttccg      180

tgacggtgca ggaaggcctg tgtgtccatg tgccctgctc cttctcctac ccctcgcatg      240

gctggattta ccctggccca gtagttcatg gctactggtt ccgggaaggg gccaatacag      300

accaggatgc tccagtggcc acaaacaacc cagctcgggc agtgtgggag gagactcggg      360

accgattcca cctccttggg gacccacata ccaagaattg caccctgagc atcagagatg      420

ccagaagaag tgatgcgggg agatacttct ttcgtatgga gaaaggaagt ataaaatgga      480

attataaaca tcaccggctc tctgtgaatg tgacagcctt gacccacagg cccaacatcc      540

tcatcccagg caccctggag tccggctgcc cccagaatct gacctgctct gtgccctggg      600

cctgtgagca ggggacaccc cctatgatct cctggatagg gacctccgtg tcccccctgg      660

acccctccac cacccgctcc tcggtgctca ccctcatccc acagccccag gaccatggca      720

ccagcctcac ctgtcaggtg accttccctg gggccagcgt gaccacgaac aagaccgtcc      780

atctcaacgt gtcctacccg cctcagaact tgaccatgac tgtcttccaa ggagacggca      840

cagtatccac agtcttggga aatggctcat ctctgtcact cccagagggc cagtctctgc      900

gcctggtctg tgcagttgat gcagttgaca gcaatccccc tgccaggctg agcctgagct      960

ggagaggcct gaccctgtgc ccctcacagc cctcaaaccc gggggtgctg gagctgcctt     1020

gggtgcacct gagggatgca gctgaattca cctgcagagc tcagaaccct ctcggctctc     1080

agcaggtcta cctgaacgtc tccctgcaga gcaaagccac atcaggagtg actcaggggg     1140

tggtcggggg agctggagcc acagccctgg tcttcctgtc cttctgcgtc atcttcgttg     1200

tagtgaggtc ctgcaggaag aaatcggcaa ggccagcagc gggcgtggga gatacgggca     1260

tagaggatgc aaacgctgtc aggggttcag cctctcaggg gcccctgact gaaccttggg     1320

cagaagacag tcccccagac cagcctcccc cagcttctgc ccgctcctca gtgggggaag     1380

gagagctcca gtatgcatcc ctcagcttcc agatggtgaa gccttgggac tcgcggggac     1440

aggaggccac tgacaccgag tactcggaga tcaagatcca cagatgagaa actgcagaga     1500

ctcaccctga ttgagggatc acagcccctc caggcaaggg agaagtcaga ggctgattct     1560

tgtagaatta acagccctca acgtgatgag ctatgataac actatgaatt atgtgcagag     1620

tgaaaagcac acaggcttta gagtcaaagt atctcaaacc tgaatccaca ctgtgccctc     1680

ccttttattt ttttaactaa aagacagaca aattcctaaa aaaaaaaaaa aaaaaaa        1737


<210> 4
<211> 463
<212> PRT
<213> Homo sapiens

<400> 4
Met Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala Glu 
1               5                   10                  15      


Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 
    50                  55                  60                  


Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 
65                  70                  75                  80  


Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 
                85                  90                  95      


Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 
            100                 105                 110         


Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 
        115                 120                 125             


Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 
    130                 135                 140                 


Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 
145                 150                 155                 160 


Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 
                165                 170                 175     


Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 
            180                 185                 190         


Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 
        195                 200                 205             


Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 
    210                 215                 220                 


Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 
225                 230                 235                 240 


Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 
                245                 250                 255     


Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 
            260                 265                 270         


Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 
        275                 280                 285             


Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 
    290                 295                 300                 


Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 
305                 310                 315                 320 


Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 
                325                 330                 335     


Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Val Val Gly Gly 
            340                 345                 350         


Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys Val Ile Phe Val 
        355                 360                 365             


Val Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly Val 
    370                 375                 380                 


Gly Asp Thr Gly Ile Glu Asp Ala Asn Ala Val Arg Gly Ser Ala Ser 
385                 390                 395                 400 


Gln Gly Pro Leu Thr Glu Pro Trp Ala Glu Asp Ser Pro Pro Asp Gln 
                405                 410                 415     


Pro Pro Pro Ala Ser Ala Arg Ser Ser Val Gly Glu Gly Glu Leu Gln 
            420                 425                 430         


Tyr Ala Ser Leu Ser Phe Gln Met Val Lys Pro Trp Asp Ser Arg Gly 
        435                 440                 445             


Gln Glu Ala Thr Asp Thr Glu Tyr Ser Glu Ile Lys Ile His Arg 
    450                 455                 460             


<210> 5
<211> 1849
<212> DNA
<213> Mus musculus

<400> 5
agagcctgga gagacagttt tagctggaca tgctgctgtt gctgctgctg ctgctgctct       60

gggggataaa gggtgtggag ggtcagaacc cccaagaggt tttcaccctg aatgtggaaa      120

ggaaggtggt ggtgcaggag ggcctgtgtg tccttgtgcc ctgtaacttc tcctatctca      180

agaagaggtt gactgactgg actgactcag acccagttca tggattctgg tacagggaag      240

gaaccgacag acgcaaagat tccatcgtgg ccacaaataa cccaattcgt aaagcagtga      300

aggaaacccg gaatcgattc ttcctgctcg gagacccttg gaggaatgac tgctccctga      360

acatcagaga gatcagaaag aaggatgcgg ggttatactt ctttcgcctg gagcgtggaa      420

aaacaaagta taattacatg tgggacaaga tgactctggt tgtaacagcc ctcactaaca      480

ccccccaaat tcttctcccg gagacgcttg aagctggcca tcccagcaac ctgacctgct      540

ctgtgccttg ggactgtggg tggacggcac ctcccatctt ctcctggact ggtacctctg      600

tgtcattttt gagcaccaac actacgggtt cctcagtgct aaccatcacc cctcagcctc      660

aggaccatgg caccaacctc acttgtcagg tgaccctgcc tggaactaat gtgtccacaa      720

gaatgaccat ccgtctcaac gtgtcatatg ctccaaagaa tctgactgtg accatctatc      780

aaggagctga ctcagtttcc acaatcctga agaatggctc atctcttcct atctctgagg      840

gccagtcact gcgtctcatc tgcagcaccg acagctatcc ccctgcgaac ctaagctggt      900

cctgggataa cctgaccctg tgcccatcaa agttgtccaa gcccgggctc ctggagctgt      960

ttccagtgca tcttaagcac ggaggagtgt atacctgcca agctcaacat gccctgggct     1020

cccaacacat ttccttgagc ctgtctccac agagcagtgc aactttatct gaaatgatga     1080

tggggacctt tgtgggttca ggagtcacag ccctcctttt cctgtctgtc tgcatcctcc     1140

tcctggcagt aagatcctac aggaggaaac cagccaggcc agctgtggta gctccgcacc     1200

cagatgccct caaggtctca gtttctcaga atcccctggt tgaatcccag gcagatgaca     1260

gctctgagcc cctgccttcc atacttgagg cggccccctc ctccacagag gaagagatac     1320

attatgcgac cctcagcttt cacgagatga agcccatgaa cctgtggggg caacaggaca     1380

ctaccacgga gtactcagag ataaagtttc cacaaaggac cgcatggcca tgaccgtggc     1440

tggagaaagc atggtggccc caggaggctg gctctggaga aggaaagagt cacctaggtt     1500

gacatgtgat acacagggct tcagagccat tccttctgtg acacaggcgt tctgtgctgc     1560

ccatgcccct gtgctgccct gtccacacaa ctgctattgt gccctgggaa tcataagctt     1620

gaccttttta ctcctcttct ccccttcccc tccttccccg ccccctcttc tcctcctcct     1680

ctctcccctc tcctcccctc ttccttttgt tttttccaag acagggtttc tctgtgtagc     1740

cttggctgtc ctagaacttg ctctgcagac cagactgccc ttgaactctt ctttccaagt     1800

gctgggatta aagatgtgca ccaccaccca gcacttgact ttattgtaa                 1849


<210> 6
<211> 467
<212> PRT
<213> Mus musculus

<400> 6
Met Leu Leu Leu Leu Leu Leu Leu Leu Leu Trp Gly Ile Lys Gly Val 
1               5                   10                  15      


Glu Gly Gln Asn Pro Gln Glu Val Phe Thr Leu Asn Val Glu Arg Lys 
            20                  25                  30          


Val Val Val Gln Glu Gly Leu Cys Val Leu Val Pro Cys Asn Phe Ser 
        35                  40                  45              


Tyr Leu Lys Lys Arg Leu Thr Asp Trp Thr Asp Ser Asp Pro Val His 
    50                  55                  60                  


Gly Phe Trp Tyr Arg Glu Gly Thr Asp Arg Arg Lys Asp Ser Ile Val 
65                  70                  75                  80  


Ala Thr Asn Asn Pro Ile Arg Lys Ala Val Lys Glu Thr Arg Asn Arg 
                85                  90                  95      


Phe Phe Leu Leu Gly Asp Pro Trp Arg Asn Asp Cys Ser Leu Asn Ile 
            100                 105                 110         


Arg Glu Ile Arg Lys Lys Asp Ala Gly Leu Tyr Phe Phe Arg Leu Glu 
        115                 120                 125             


Arg Gly Lys Thr Lys Tyr Asn Tyr Met Trp Asp Lys Met Thr Leu Val 
    130                 135                 140                 


Val Thr Ala Leu Thr Asn Thr Pro Gln Ile Leu Leu Pro Glu Thr Leu 
145                 150                 155                 160 


Glu Ala Gly His Pro Ser Asn Leu Thr Cys Ser Val Pro Trp Asp Cys 
                165                 170                 175     


Gly Trp Thr Ala Pro Pro Ile Phe Ser Trp Thr Gly Thr Ser Val Ser 
            180                 185                 190         


Phe Leu Ser Thr Asn Thr Thr Gly Ser Ser Val Leu Thr Ile Thr Pro 
        195                 200                 205             


Gln Pro Gln Asp His Gly Thr Asn Leu Thr Cys Gln Val Thr Leu Pro 
    210                 215                 220                 


Gly Thr Asn Val Ser Thr Arg Met Thr Ile Arg Leu Asn Val Ser Tyr 
225                 230                 235                 240 


Ala Pro Lys Asn Leu Thr Val Thr Ile Tyr Gln Gly Ala Asp Ser Val 
                245                 250                 255     


Ser Thr Ile Leu Lys Asn Gly Ser Ser Leu Pro Ile Ser Glu Gly Gln 
            260                 265                 270         


Ser Leu Arg Leu Ile Cys Ser Thr Asp Ser Tyr Pro Pro Ala Asn Leu 
        275                 280                 285             


Ser Trp Ser Trp Asp Asn Leu Thr Leu Cys Pro Ser Lys Leu Ser Lys 
    290                 295                 300                 


Pro Gly Leu Leu Glu Leu Phe Pro Val His Leu Lys His Gly Gly Val 
305                 310                 315                 320 


Tyr Thr Cys Gln Ala Gln His Ala Leu Gly Ser Gln His Ile Ser Leu 
                325                 330                 335     


Ser Leu Ser Pro Gln Ser Ser Ala Thr Leu Ser Glu Met Met Met Gly 
            340                 345                 350         


Thr Phe Val Gly Ser Gly Val Thr Ala Leu Leu Phe Leu Ser Val Cys 
        355                 360                 365             


Ile Leu Leu Leu Ala Val Arg Ser Tyr Arg Arg Lys Pro Ala Arg Pro 
    370                 375                 380                 


Ala Val Val Ala Pro His Pro Asp Ala Leu Lys Val Ser Val Ser Gln 
385                 390                 395                 400 


Asn Pro Leu Val Glu Ser Gln Ala Asp Asp Ser Ser Glu Pro Leu Pro 
                405                 410                 415     


Ser Ile Leu Glu Ala Ala Pro Ser Ser Thr Glu Glu Glu Ile His Tyr 
            420                 425                 430         


Ala Thr Leu Ser Phe His Glu Met Lys Pro Met Asn Leu Trp Gly Gln 
        435                 440                 445             


Gln Asp Thr Thr Thr Glu Tyr Ser Glu Ile Lys Phe Pro Gln Arg Thr 
    450                 455                 460                 


Ala Trp Pro 
465         


<210> 7
<211> 1869
<212> DNA
<213> Homo sapiens

<400> 7
ggagtttgag tgagagatat agggaaggaa gggaagtaag cagtcacaga cgctggcggc       60

caccagaagt ttgagcctct ttggtagcag gaggctggaa gaaaggacag aagtagctct      120

ggctgtgatg gggatcttac tgggcctgct actcctgggg cacctaacag tggacactta      180

tggccgtccc atcctggaag tgccagagag tgtaacagga ccttggaaag gggatgtgaa      240

tcttccctgc acctatgacc ccctgcaagg ctacacccaa gtcttggtga agtggctggt      300

acaacgtggc tcagaccctg tcaccatctt tctacgtgac tcttctggag accatatcca      360

gcaggcaaag taccagggcc gcctgcatgt gagccacaag gttccaggag atgtatccct      420

ccaattgagc accctggaga tggatgaccg gagccactac acgtgtgaag tcacctggca      480

gactcctgat ggcaaccaag tcgtgagaga taagattact gagctccgtg tccagaaact      540

ctctgtctcc aagcccacag tgacaactgg cagcggttat ggcttcacgg tgccccaggg      600

aatgaggatt agccttcaat gccaggctcg gggttctcct cccatcagtt atatttggta      660

taagcaacag actaataacc aggaacccat caaagtagca accctaagta ccttactctt      720

caagcctgcg gtgatagccg actcaggctc ctatttctgc actgccaagg gccaggttgg      780

ctctgagcag cacagcgaca ttgtgaagtt tgtggtcaaa gactcctcaa agctactcaa      840

gaccaagact gaggcaccta caaccatgac ataccccttg aaagcaacat ctacagtgaa      900

gcagtcctgg gactggacca ctgacatgga tggctacctt ggagagacca gtgctgggcc      960

aggaaagagc ctgcctgtct ttgccatcat cctcatcatc tccttgtgct gtatggtggt     1020

ttttaccatg gcctatatca tgctctgtcg gaagacatcc caacaagagc atgtctacga     1080

agcagccagg gcacatgcca gagaggccaa cgactctgga gaaaccatga gggtggccat     1140

cttcgcaagt ggctgctcca gtgatgagcc aacttcccag aatctgggca acaactactc     1200

tgatgagccc tgcataggac aggagtacca gatcatcgcc cagatcaatg gcaactacgc     1260

ccgcctgctg gacacagttc ctctggatta tgagtttctg gccactgagg gcaaaagtgt     1320

ctgttaaaaa tgccccatta ggccaggatc tgctgacata attgcctagt cagtccttgc     1380

cttctgcatg gccttcttcc ctgctacctc tcttcctgga tagcccaaag tgtccgccta     1440

ccaacactgg agccgctggg agtcactggc tttgccctgg aatttgccag atgcatctca     1500

agtaagccag ctgctggatt tggctctggg cccttctagt atctctgccg ggggcttctg     1560

gtactcctct ctaaatacca gagggaagat gcccatagca ctaggacttg gtcatcatgc     1620

ctacagacac tattcaactt tggcatcttg ccaccagaag acccgaggga ggctcagctc     1680

tgccagctca gaggaccagc tatatccagg atcatttctc tttcttcagg gccagacagc     1740

ttttaattga aattgttatt tcacaggcca gggttcagtt ctgctcctcc actataagtc     1800

taatgttctg actctctcct ggtgctcaat aaatatctaa tcataacagc aaaaaaaaaa     1860

aaaaaaaaa                                                             1869


<210> 8
<211> 399
<212> PRT
<213> Homo sapiens

<400> 8
Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro Thr 
    130                 135                 140                 


Val Thr Thr Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met Arg 
145                 150                 155                 160 


Ile Ser Leu Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr Ile 
                165                 170                 175     


Trp Tyr Lys Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala Thr 
            180                 185                 190         


Leu Ser Thr Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly Ser 
        195                 200                 205             


Tyr Phe Cys Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser Asp 
    210                 215                 220                 


Ile Val Lys Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr Lys 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser Thr 
                245                 250                 255     


Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu Gly 
            260                 265                 270         


Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala Ile Ile 
        275                 280                 285             


Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala Tyr Ile 
    290                 295                 300                 


Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu Ala Ala 
305                 310                 315                 320 


Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu Thr Met Arg Val 
                325                 330                 335     


Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro Thr Ser Gln Asn 
            340                 345                 350         


Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly Gln Glu Tyr Gln 
        355                 360                 365             


Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu Leu Asp Thr Val 
    370                 375                 380                 


Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys Ser Val Cys 
385                 390                 395                 


<210> 9
<211> 1586
<212> DNA
<213> Homo sapiens

<400> 9
ggagtttgag tgagagatat agggaaggaa gggaagtaag cagtcacaga cgctggcggc       60

caccagaagt ttgagcctct ttggtagcag gaggctggaa gaaaggacag aagtagctct      120

ggctgtgatg gggatcttac tgggcctgct actcctgggg cacctaacag tggacactta      180

tggccgtccc atcctggaag tgccagagag tgtaacagga ccttggaaag gggatgtgaa      240

tcttccctgc acctatgacc ccctgcaagg ctacacccaa gtcttggtga agtggctggt      300

acaacgtggc tcagaccctg tcaccatctt tctacgtgac tcttctggag accatatcca      360

gcaggcaaag taccagggcc gcctgcatgt gagccacaag gttccaggag atgtatccct      420

ccaattgagc accctggaga tggatgaccg gagccactac acgtgtgaag tcacctggca      480

gactcctgat ggcaaccaag tcgtgagaga taagattact gagctccgtg tccagaaaca      540

ctcctcaaag ctactcaaga ccaagactga ggcacctaca accatgacat accccttgaa      600

agcaacatct acagtgaagc agtcctggga ctggaccact gacatggatg gctaccttgg      660

agagaccagt gctgggccag gaaagagcct gcctgtcttt gccatcatcc tcatcatctc      720

cttgtgctgt atggtggttt ttaccatggc ctatatcatg ctctgtcgga agacatccca      780

acaagagcat gtctacgaag cagccagggc acatgccaga gaggccaacg actctggaga      840

aaccatgagg gtggccatct tcgcaagtgg ctgctccagt gatgagccaa cttcccagaa      900

tctgggcaac aactactctg atgagccctg cataggacag gagtaccaga tcatcgccca      960

gatcaatggc aactacgccc gcctgctgga cacagttcct ctggattatg agtttctggc     1020

cactgagggc aaaagtgtct gttaaaaatg ccccattagg ccaggatctg ctgacataat     1080

tgcctagtca gtccttgcct tctgcatggc cttcttccct gctacctctc ttcctggata     1140

gcccaaagtg tccgcctacc aacactggag ccgctgggag tcactggctt tgccctggaa     1200

tttgccagat gcatctcaag taagccagct gctggatttg gctctgggcc cttctagtat     1260

ctctgccggg ggcttctggt actcctctct aaataccaga gggaagatgc ccatagcact     1320

aggacttggt catcatgcct acagacacta ttcaactttg gcatcttgcc accagaagac     1380

ccgagggagg ctcagctctg ccagctcaga ggaccagcta tatccaggat catttctctt     1440

tcttcagggc cagacagctt ttaattgaaa ttgttatttc acaggccagg gttcagttct     1500

gctcctccac tataagtcta atgttctgac tctctcctgg tgctcaataa atatctaatc     1560

ataacagcaa aaaaaaaaaa aaaaaa                                          1586


<210> 10
<211> 305
<212> PRT
<213> Homo sapiens

<400> 10
Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys His Ser Ser Lys Leu Leu Lys 
    130                 135                 140                 


Thr Lys Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr 
145                 150                 155                 160 


Ser Thr Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr 
                165                 170                 175     


Leu Gly Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala 
            180                 185                 190         


Ile Ile Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala 
        195                 200                 205             


Tyr Ile Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu 
    210                 215                 220                 


Ala Ala Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu Thr Met 
225                 230                 235                 240 


Arg Val Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro Thr Ser 
                245                 250                 255     


Gln Asn Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly Gln Glu 
            260                 265                 270         


Tyr Gln Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu Leu Asp 
        275                 280                 285             


Thr Val Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys Ser Val 
    290                 295                 300                 


Cys 
305 


<210> 11
<211> 1927
<212> DNA
<213> Homo sapiens

<400> 11
ggagtttgag tgagagatat agggaaggaa gggaagtaag cagtcacaga cgctggcggc       60

caccagaagt ttgagcctct ttggtagcag gaggctggaa gaaaggacag aagtagctct      120

ggctgtgatg gggatcttac tgggcctgct actcctgggg cacctaacag tggacactta      180

tggccgtccc atcctggaag tgccagagag tgtaacagga ccttggaaag gggatgtgaa      240

tcttccctgc acctatgacc ccctgcaagg ctacacccaa gtcttggtga agtggctggt      300

acaacgtggc tcagaccctg tcaccatctt tctacgtgac tcttctggag accatatcca      360

gcaggcaaag taccagggcc gcctgcatgt gagccacaag gttccaggag atgtatccct      420

ccaattgagc accctggaga tggatgaccg gagccactac acgtgtgaag tcacctggca      480

gactcctgat ggcaaccaag tcgtgagaga taagattact gagctccgtg tccagaaaca      540

ctcctcaaag ctactcaaga ccaagactga ggcacctaca accatgacat accccttgaa      600

agcaacatct acagtgaagc agtcctggga ctggaccact gacatggatg gctaccttgg      660

agagaccagt gctgggccag gaaagagcct gcctgtcttt gccatcatcc tcatcatctc      720

cttgtgctgt atggtggttt ttaccatggc ctatatcatg ctctgtcgga agacatccca      780

acaagagcat gtctacgaag cagccaggta agaaagtctc tcctcttcca tttttgaccc      840

cgtccctgcc ctcaattttg attactggca ggaaatgtgg aggaaggggg gtgtggcaca      900

gacccaatcc taaggccgga ggccttcagg gtcaggacat agctgccttc cctctctcag      960

gcaccttctg aggttgtttt ggccctctga acacaaagga taatttagat ccatctgcct     1020

tctgcttcca gaatccctgg gtggtaggat cctgataatt aattggcaag aattgaggca     1080

gaagggtggg aaaccaggac cacagcccca agtcccttct tatgggtggt gggctcttgg     1140

gccatagggc acatgccaga gaggccaacg actctggaga aaccatgagg gtggccatct     1200

tcgcaagtgg ctgctccagt gatgagccaa cttcccagaa tctgggcaac aactactctg     1260

atgagccctg cataggacag gagtaccaga tcatcgccca gatcaatggc aactacgccc     1320

gcctgctgga cacagttcct ctggattatg agtttctggc cactgagggc aaaagtgtct     1380

gttaaaaatg ccccattagg ccaggatctg ctgacataat tgcctagtca gtccttgcct     1440

tctgcatggc cttcttccct gctacctctc ttcctggata gcccaaagtg tccgcctacc     1500

aacactggag ccgctgggag tcactggctt tgccctggaa tttgccagat gcatctcaag     1560

taagccagct gctggatttg gctctgggcc cttctagtat ctctgccggg ggcttctggt     1620

actcctctct aaataccaga gggaagatgc ccatagcact aggacttggt catcatgcct     1680

acagacacta ttcaactttg gcatcttgcc accagaagac ccgagggagg ctcagctctg     1740

ccagctcaga ggaccagcta tatccaggat catttctctt tcttcagggc cagacagctt     1800

ttaattgaaa ttgttatttc acaggccagg gttcagttct gctcctccac tataagtcta     1860

atgttctgac tctctcctgg tgctcaataa atatctaatc ataacagcaa aaaaaaaaaa     1920

aaaaaaa                                                               1927


<210> 12
<211> 227
<212> PRT
<213> Homo sapiens

<400> 12
Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys His Ser Ser Lys Leu Leu Lys 
    130                 135                 140                 


Thr Lys Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr 
145                 150                 155                 160 


Ser Thr Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr 
                165                 170                 175     


Leu Gly Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala 
            180                 185                 190         


Ile Ile Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala 
        195                 200                 205             


Tyr Ile Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu 
    210                 215                 220                 


Ala Ala Arg 
225         


<210> 13
<211> 2209
<212> DNA
<213> Homo sapiens

<400> 13
ggagtttgag tgagagatat agggaaggaa gggaagtaag cagtcacaga cgctggcggc       60

caccagaagt ttgagcctct ttggtagcag gaggctggaa gaaaggacag aagtagctct      120

ggctgtgatg gggatcttac tgggcctgct actcctgggg cacctaacag tggacactta      180

tggccgtccc atcctggaag tgccagagag tgtaacagga ccttggaaag gggatgtgaa      240

tcttccctgc acctatgacc ccctgcaagg ctacacccaa gtcttggtga agtggctggt      300

acaacgtggc tcagaccctg tcaccatctt tctacgtgac tcttctggag accatatcca      360

gcaggcaaag taccagggcc gcctgcatgt gagccacaag gttccaggag atgtatccct      420

ccaattgagc accctggaga tggatgaccg gagccactac acgtgtgaag tcacctggca      480

gactcctgat ggcaaccaag tcgtgagaga taagattact gagctccgtg tccagaaact      540

ctctgtctcc aagcccacag tgacaactgg cagcggttat ggcttcacgg tgccccaggg      600

aatgaggatt agccttcaat gccaggctcg gggttctcct cccatcagtt atatttggta      660

taagcaacag actaataacc aggaacccat caaagtagca accctaagta ccttactctt      720

caagcctgcg gtgatagccg actcaggctc ctatttctgc actgccaagg gccaggttgg      780

ctctgagcag cacagcgaca ttgtgaagtt tgtggtcaaa gactcctcaa agctactcaa      840

gaccaagact gaggcaccta caaccatgac ataccccttg aaagcaacat ctacagtgaa      900

gcagtcctgg gactggacca ctgacatgga tggctacctt ggagagacca gtgctgggcc      960

aggaaagagc ctgcctgtct ttgccatcat cctcatcatc tccttgtgct gtatggtggt     1020

ttttaccatg gcctatatca tgctctgtcg gaagacatcc caacaagagc atgtctacga     1080

agcagccagg taagaaagtc tctcctcttc catttttgac cccgtccctg ccctcaattt     1140

tgattactgg caggaaatgt ggaggaaggg gggtgtggca cagacccaat cctaaggccg     1200

gaggccttca gggtcaggac atagctgcct tccctctctc aggcaccttc tgaggttgtt     1260

ttggccctct gaacacaaag gataatttag atccatctgc cttctgcttc cagaatccct     1320

gggtggtagg atcctgataa ttaattggca agaattgagg cagaagggtg ggaaaccagg     1380

accacagccc caagtccctt cttatgggtg gtgggctctt gggccatagg gcacatgcca     1440

gagaggccaa cgactctgga gaaaccatga gggtggccat cttcgcaagt ggctgctcca     1500

gtgatgagcc aacttcccag aatctgggca acaactactc tgatgagccc tgcataggac     1560

aggagtacca gatcatcgcc cagatcaatg gcaactacgc ccgcctgctg gacacagttc     1620

ctctggatta tgagtttctg gccactgagg gcaaaagtgt ctgttaaaaa tgccccatta     1680

ggccaggatc tgctgacata attgcctagt cagtccttgc cttctgcatg gccttcttcc     1740

ctgctacctc tcttcctgga tagcccaaag tgtccgccta ccaacactgg agccgctggg     1800

agtcactggc tttgccctgg aatttgccag atgcatctca agtaagccag ctgctggatt     1860

tggctctggg cccttctagt atctctgccg ggggcttctg gtactcctct ctaaatacca     1920

gagggaagat gcccatagca ctaggacttg gtcatcatgc ctacagacac tattcaactt     1980

tggcatcttg ccaccagaag acccgaggga ggctcagctc tgccagctca gaggaccagc     2040

tatatccagg atcatttctc tttcttcagg gccagacagc ttttaattga aattgttatt     2100

tcacaggcca gggttcagtt ctgctcctcc actataagtc taatgttctg actctctcct     2160

ggtgctcaat aaatatctaa tcataacagc aaaaaaaaaa aaaaaaaaa                 2209


<210> 14
<211> 321
<212> PRT
<213> Homo sapiens

<400> 14
Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro Thr 
    130                 135                 140                 


Val Thr Thr Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met Arg 
145                 150                 155                 160 


Ile Ser Leu Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr Ile 
                165                 170                 175     


Trp Tyr Lys Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala Thr 
            180                 185                 190         


Leu Ser Thr Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly Ser 
        195                 200                 205             


Tyr Phe Cys Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser Asp 
    210                 215                 220                 


Ile Val Lys Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr Lys 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser Thr 
                245                 250                 255     


Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu Gly 
            260                 265                 270         


Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala Ile Ile 
        275                 280                 285             


Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala Tyr Ile 
    290                 295                 300                 


Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu Ala Ala 
305                 310                 315                 320 


Arg 
    


<210> 15
<211> 1535
<212> DNA
<213> Homo sapiens

<400> 15
ggagtttgag tgagagatat agggaaggaa gggaagtaag cagtcacaga cgctggcggc       60

caccagaagt ttgagcctct ttggtagcag gaggctggaa gaaaggacag aagtagctct      120

ggctgtgatg gggatcttac tgggcctgct actcctgggg cacctaacag tggacactta      180

tggccgtccc atcctggaag tgccagagag tgtaacagga ccttggaaag gggatgtgaa      240

tcttccctgc acctatgacc ccctgcaagg ctacacccaa gtcttggtga agtggctggt      300

acaacgtggc tcagaccctg tcaccatctt tctacgtgac tcttctggag accatatcca      360

gcaggcaaag taccagggcc gcctgcatgt gagccacaag gttccaggag atgtatccct      420

ccaattgagc accctggaga tggatgaccg gagccactac acgtgtgaag tcacctggca      480

gactcctgat ggcaaccaag tcgtgagaga taagattact gagctccgtg tccagaaact      540

ctctgtctcc aagcccacag tgacaactgg cagcggttat ggcttcacgg tgccccaggg      600

aatgaggatt agccttcaat gccaggctcg gggttctcct cccatcagtt atatttggta      660

taagcaacag actaataacc aggaacccat caaagtagca accctaagta ccttactctt      720

caagcctgcg gtgatagccg actcaggctc ctatttctgc actgccaagg gccaggttgg      780

ctctgagcag cacagcgaca ttgtgaagtt tgtggtcaaa gactcctcaa agctactcaa      840

gaccaagact gaggcaccta caaccatgac ataccccttg aaagcaacat ctacagtgaa      900

gcagtcctgg gactggacca ctgacatgga tggctacctt ggagagacca gtgctgggcc      960

aggaaagagc ctgcctgtct ttgccatcat cctcatcatc tccttgtgct gtatggtggt     1020

ttttaccatg gcctatatca tgctctgtcg gaagacatcc caacaagagc atgtctacga     1080

agcagccagc ccaaagtgtc cgcctaccaa cactggagcc gctgggagtc actggctttg     1140

ccctggaatt tgccagatgc atctcaagta agccagctgc tggatttggc tctgggccct     1200

tctagtatct ctgccggggg cttctggtac tcctctctaa ataccagagg gaagatgccc     1260

atagcactag gacttggtca tcatgcctac agacactatt caactttggc atcttgccac     1320

cagaagaccc gagggaggct cagctctgcc agctcagagg accagctata tccaggatca     1380

tttctctttc ttcagggcca gacagctttt aattgaaatt gttatttcac aggccagggt     1440

tcagttctgc tcctccacta taagtctaat gttctgactc tctcctggtg ctcaataaat     1500

atctaatcat aacagcaaaa aaaaaaaaaa aaaaa                                1535


<210> 16
<211> 347
<212> PRT
<213> Homo sapiens

<400> 16
Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro Thr 
    130                 135                 140                 


Val Thr Thr Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met Arg 
145                 150                 155                 160 


Ile Ser Leu Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr Ile 
                165                 170                 175     


Trp Tyr Lys Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala Thr 
            180                 185                 190         


Leu Ser Thr Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly Ser 
        195                 200                 205             


Tyr Phe Cys Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser Asp 
    210                 215                 220                 


Ile Val Lys Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr Lys 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser Thr 
                245                 250                 255     


Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu Gly 
            260                 265                 270         


Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala Ile Ile 
        275                 280                 285             


Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala Tyr Ile 
    290                 295                 300                 


Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu Ala Ala 
305                 310                 315                 320 


Ser Pro Lys Cys Pro Pro Thr Asn Thr Gly Ala Ala Gly Ser His Trp 
                325                 330                 335     


Leu Cys Pro Gly Ile Cys Gln Met His Leu Lys 
            340                 345         


<210> 17
<211> 1432
<212> DNA
<213> Mus musculus

<400> 17
agctaccagc acttccaggt tcttcagcag caagaggatg gaaggatgaa tagaagtagc       60

ttcaaatagg atggagatct catcaggctt gctgttcctg ggccacctaa tagtgctcac      120

ctatggccac cccaccctaa aaacacctga gagtgtgaca gggacctgga aaggagatgt      180

gaagattcag tgcatctatg atcccctgag aggctacagg caagttttgg tgaaatggct      240

ggtaagacac ggctctgact ccgtcaccat cttcctacgt gactccactg gagaccatat      300

ccagcaggca aagtacagag gccgcctgaa agtgagccac aaagttccag gagatgtgtc      360

cctccaaata aataccctgc agatggatga caggaatcac tatacatgtg aggtcacctg      420

gcagactcct gatggaaacc aagtaataag agataagatc attgagctcc gtgttcggaa      480

atataatcca cctagaatca atactgaagc acctacaacc ctgcactcct ctttggaagc      540

aacaactata atgagttcaa cctctgactt gaccactaat gggactggaa aacttgagga      600

gaccattgct ggttcaggga ggaacctgcc aatctttgcc ataatcttca tcatctccct      660

ttgctgcata gtagctgtca ccatacctta tatcttgttc cgctgcagga cattccaaca      720

agagtatgtc tatggagtga gcagggtgtt tgccaggaag acaagcaact ctgaagaaac      780

cacaagggtg actaccatcg caactgatga accagattcc caggctctga ttagtgacta      840

ctctgatgat ccttgcctca gccaggagta ccaaataacc atcagatcaa caatgtctat      900

tcctgcctgc tgaacacagt ttccagaaac taagaagttc ttgctactga agaaaataac      960

atctgctaaa atgcccctac taagtcaagg tctactggcg taattacctg ttacttattt     1020

actacttgcc ttcaacatag ctttctccct ggcttccttt cttcttagac aacctaaagt     1080

atctatctag tctgccaatt ctggggccat tgagaaatcc tgggtttggc taagaatata     1140

ctacatgcac ctcaagaaat ctagcttctg ggcttcaccc agaacaattt tcttcctagg     1200

gccttcacaa ctcttctcca aacagcagag aaattccata gcagtagagg ttctttatca     1260

tgcctccaga cagcgtgagt ctcagtccta caaactcaga caagcacatg ggtctaggat     1320

tactcctctt tctctagggc cagatgactt ttaattgata ttactattgc tacattatga     1380

atctaatgca catgtattct tttgttgtta ataaatgttt aatcatgaca tc             1432


<210> 18
<211> 280
<212> PRT
<213> Mus musculus

<400> 18
Met Glu Ile Ser Ser Gly Leu Leu Phe Leu Gly His Leu Ile Val Leu 
1               5                   10                  15      


Thr Tyr Gly His Pro Thr Leu Lys Thr Pro Glu Ser Val Thr Gly Thr 
            20                  25                  30          


Trp Lys Gly Asp Val Lys Ile Gln Cys Ile Tyr Asp Pro Leu Arg Gly 
        35                  40                  45              


Tyr Arg Gln Val Leu Val Lys Trp Leu Val Arg His Gly Ser Asp Ser 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Thr Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Arg Gly Arg Leu Lys Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Ile Asn Thr Leu Gln Met Asp Asp Arg Asn His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Ile Arg Asp 
        115                 120                 125             


Lys Ile Ile Glu Leu Arg Val Arg Lys Tyr Asn Pro Pro Arg Ile Asn 
    130                 135                 140                 


Thr Glu Ala Pro Thr Thr Leu His Ser Ser Leu Glu Ala Thr Thr Ile 
145                 150                 155                 160 


Met Ser Ser Thr Ser Asp Leu Thr Thr Asn Gly Thr Gly Lys Leu Glu 
                165                 170                 175     


Glu Thr Ile Ala Gly Ser Gly Arg Asn Leu Pro Ile Phe Ala Ile Ile 
            180                 185                 190         


Phe Ile Ile Ser Leu Cys Cys Ile Val Ala Val Thr Ile Pro Tyr Ile 
        195                 200                 205             


Leu Phe Arg Cys Arg Thr Phe Gln Gln Glu Tyr Val Tyr Gly Val Ser 
    210                 215                 220                 


Arg Val Phe Ala Arg Lys Thr Ser Asn Ser Glu Glu Thr Thr Arg Val 
225                 230                 235                 240 


Thr Thr Ile Ala Thr Asp Glu Pro Asp Ser Gln Ala Leu Ile Ser Asp 
                245                 250                 255     


Tyr Ser Asp Asp Pro Cys Leu Ser Gln Glu Tyr Gln Ile Thr Ile Arg 
            260                 265                 270         


Ser Thr Met Ser Ile Pro Ala Cys 
        275                 280 


<210> 19
<211> 1698
<212> DNA
<213> Homo sapiens

<400> 19
ctgcctgggg agcccccccg ccccacatcc tgccccgcaa aaggcagctt caccaaagtg       60

gggtatttcc agcctttgta gctttcactt ccacatctac caagtgggcg gagtggcctt      120

ctgtggacga atcagattcc tctccagcac cgactttaag aggcgagccg gggggtcagg      180

gtcccagatg cacaggagga gaagcaggag ctgtcgggaa gatcagaagc cagtcatgga      240

tgaccagcgc gaccttatct ccaacaatga gcaactgccc atgctgggcc ggcgccctgg      300

ggccccggag agcaagtgca gccgcggagc cctgtacaca ggcttttcca tcctggtgac      360

tctgctcctc gctggccagg ccaccaccgc ctacttcctg taccagcagc agggccggct      420

ggacaaactg acagtcacct cccagaacct gcagctggag aacctgcgca tgaagcttcc      480

caagcctccc aagcctgtga gcaagatgcg catggccacc ccgctgctga tgcaggcgct      540

gcccatggga gccctgcccc aggggcccat gcagaatgcc accaagtatg gcaacatgac      600

agaggaccat gtgatgcacc tgctccagaa tgctgacccc ctgaaggtgt acccgccact      660

gaaggggagc ttcccggaga acctgagaca ccttaagaac accatggaga ccatagactg      720

gaaggtcttt gagagctgga tgcaccattg gctcctgttt gaaatgagca ggcactcctt      780

ggagcaaaag cccactgacg ctccaccgaa agtactgacc aagtgccagg aagaggtcag      840

ccacatccct gctgtccacc cgggttcatt caggcccaag tgcgacgaga acggcaacta      900

tctgccactc cagtgctatg ggagcatcgg ctactgctgg tgtgtcttcc ccaacggcac      960

ggaggtcccc aacaccagaa gccgcgggca ccataactgc agtgagtcac tggaactgga     1020

ggacccgtct tctgggctgg gtgtgaccaa gcaggatctg ggcccagtcc ccatgtgaga     1080

gcagcagagg cggtcttcaa catcctgcca gccccacaca gctacagctt tcttgctccc     1140

ttcagccccc agcccctccc ccatctccca ccctgtacct catcccatga gaccctggtg     1200

cctggctctt tcgtcaccct tggacaagac aaaccaagtc ggaacagcag ataacaatgc     1260

agcaaggccc tgctgcccaa tctccatctg tcaacagggg cgtgaggtcc caggaagtgg     1320

ccaaaagcta gacagatccc cgttcctgac atcacagcag cctccaacac aaggctccaa     1380

gacctaggct catggacgag atgggaaggc acagggagaa gggataaccc tacacccaga     1440

ccccaggctg gacatgctga ctgtcctctc ccctccagcc tttggccttg gcttttctag     1500

cctatttacc tgcaggctga gccactctct tccctttccc cagcatcact ccccaaggaa     1560

gagccaatgt tttccaccca taatcctttc tgccgacccc tagttccctc tgctcagcca     1620

agcttgttat cagctttcag ggccatggtt cacattagaa taaaaggtag taattagaac     1680

aaaaaaaaaa aaaaaaaa                                                   1698


<210> 20
<211> 296
<212> PRT
<213> Homo sapiens

<400> 20
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
    210                 215                 220                 


Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
225                 230                 235                 240 


Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                245                 250                 255     


Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
            260                 265                 270         


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
        275                 280                 285             


Gln Asp Leu Gly Pro Val Pro Met 
    290                 295     


<210> 21
<211> 1506
<212> DNA
<213> Homo sapiens

<400> 21
ctgcctgggg agcccccccg ccccacatcc tgccccgcaa aaggcagctt caccaaagtg       60

gggtatttcc agcctttgta gctttcactt ccacatctac caagtgggcg gagtggcctt      120

ctgtggacga atcagattcc tctccagcac cgactttaag aggcgagccg gggggtcagg      180

gtcccagatg cacaggagga gaagcaggag ctgtcgggaa gatcagaagc cagtcatgga      240

tgaccagcgc gaccttatct ccaacaatga gcaactgccc atgctgggcc ggcgccctgg      300

ggccccggag agcaagtgca gccgcggagc cctgtacaca ggcttttcca tcctggtgac      360

tctgctcctc gctggccagg ccaccaccgc ctacttcctg taccagcagc agggccggct      420

ggacaaactg acagtcacct cccagaacct gcagctggag aacctgcgca tgaagcttcc      480

caagcctccc aagcctgtga gcaagatgcg catggccacc ccgctgctga tgcaggcgct      540

gcccatggga gccctgcccc aggggcccat gcagaatgcc accaagtatg gcaacatgac      600

agaggaccat gtgatgcacc tgctccagaa tgctgacccc ctgaaggtgt acccgccact      660

gaaggggagc ttcccggaga acctgagaca ccttaagaac accatggaga ccatagactg      720

gaaggtcttt gagagctgga tgcaccattg gctcctgttt gaaatgagca ggcactcctt      780

ggagcaaaag cccactgacg ctccaccgaa agagtcactg gaactggagg acccgtcttc      840

tgggctgggt gtgaccaagc aggatctggg cccagtcccc atgtgagagc agcagaggcg      900

gtcttcaaca tcctgccagc cccacacagc tacagctttc ttgctccctt cagcccccag      960

cccctccccc atctcccacc ctgtacctca tcccatgaga ccctggtgcc tggctctttc     1020

gtcacccttg gacaagacaa accaagtcgg aacagcagat aacaatgcag caaggccctg     1080

ctgcccaatc tccatctgtc aacaggggcg tgaggtccca ggaagtggcc aaaagctaga     1140

cagatccccg ttcctgacat cacagcagcc tccaacacaa ggctccaaga cctaggctca     1200

tggacgagat gggaaggcac agggagaagg gataacccta cacccagacc ccaggctgga     1260

catgctgact gtcctctccc ctccagcctt tggccttggc ttttctagcc tatttacctg     1320

caggctgagc cactctcttc cctttcccca gcatcactcc ccaaggaaga gccaatgttt     1380

tccacccata atcctttctg ccgaccccta gttccctctg ctcagccaag cttgttatca     1440

gctttcaggg ccatggttca cattagaata aaaggtagta attagaacaa aaaaaaaaaa     1500

aaaaaa                                                                1506


<210> 22
<211> 232
<212> PRT
<213> Homo sapiens

<400> 22
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
    210                 215                 220                 


Gln Asp Leu Gly Pro Val Pro Met 
225                 230         


<210> 23
<211> 1322
<212> DNA
<213> Homo sapiens

<400> 23
ctgcctgggg agcccccccg ccccacatcc tgccccgcaa aaggcagctt caccaaagtg       60

gggtatttcc agcctttgta gctttcactt ccacatctac caagtgggcg gagtggcctt      120

ctgtggacga atcagattcc tctccagcac cgactttaag aggcgagccg gggggtcagg      180

gtcccagatg cacaggagga gaagcaggag ctgtcgggaa gatcagaagc cagtcatgga      240

tgaccagcgc gaccttatct ccaacaatga gcaactgccc atgctgggcc ggcgccctgg      300

ggccccggag agcaagtgca gccgcggagc cctgtacaca ggcttttcca tcctggtgac      360

tctgctcctc gctggccagg ccaccaccgc ctacttcctg taccagcagc agggccggct      420

ggacaaactg acagtcacct cccagaacct gcagctggag aacctgcgca tgaagcttcc      480

caagcctccc aagcctgtga gcaagatgcg catggccacc ccgctgctga tgcaggcgct      540

gcccatggga gccctgcccc aggggcccat gcagaatgcc accaagtatg gcaacatgac      600

agaggaccat gtgatgcacc tgctccagag tcactggaac tggaggaccc gtcttctggg      660

ctgggtgtga ccaagcagga tctgggccca gtccccatgt gagagcagca gaggcggtct      720

tcaacatcct gccagcccca cacagctaca gctttcttgc tcccttcagc ccccagcccc      780

tcccccatct cccaccctgt acctcatccc atgagaccct ggtgcctggc tctttcgtca      840

cccttggaca agacaaacca agtcggaaca gcagataaca atgcagcaag gccctgctgc      900

ccaatctcca tctgtcaaca ggggcgtgag gtcccaggaa gtggccaaaa gctagacaga      960

tccccgttcc tgacatcaca gcagcctcca acacaaggct ccaagaccta ggctcatgga     1020

cgagatggga aggcacaggg agaagggata accctacacc cagaccccag gctggacatg     1080

ctgactgtcc tctcccctcc agcctttggc cttggctttt ctagcctatt tacctgcagg     1140

ctgagccact ctcttccctt tccccagcat cactccccaa ggaagagcca atgttttcca     1200

cccataatcc tttctgccga cccctagttc cctctgctca gccaagcttg ttatcagctt     1260

tcagggccat ggttcacatt agaataaaag gtagtaatta gaacaaaaaa aaaaaaaaaa     1320

aa                                                                    1322


<210> 24
<211> 160
<212> PRT
<213> Homo sapiens

<400> 24
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Ser His Trp Asn Trp Arg Thr Arg Leu Leu Gly Trp Val 
145                 150                 155                 160 


<210> 25
<211> 1431
<212> DNA
<213> Mus musculus

<400> 25
agacacacag cagcagcagc agcagcagca gcagcaacag cagcagcagc agcagcgcct       60

gtgggaaaaa ctagaggcta gagccatgga tgaccaacgc gacctcatct ctaaccatga      120

acagttgccc atactgggca accgccctag agagccagaa aggtgcagcc gtggagctct      180

gtacaccggt gtctctgtcc tggtggctct gctcttggct gggcaggcca ccactgctta      240

cttcctgtac cagcaacagg gccgcctaga caagctgacc atcacctccc agaacctgca      300

actggagagc cttcgcatga agcttccgaa atctgccaaa cctgtgagcc agatgcggat      360

ggctactccc ttgctgatgc gtccaatgtc catggataac atgctccttg ggcctgtgaa      420

gaacgttacc aagtacggca acatgaccca ggaccatgtg atgcatctgc tcacgaggtc      480

tggacccctg gagtacccgc agctgaaggg gaccttccca gagaatctga agcatcttaa      540

gaactccatg gatggcgtga actggaagat cttcgagagc tggatgaagc agtggctctt      600

gtttgagatg agcaagaact ccctggagga gaagaagccc accgaggctc cacctaaagt      660

actgaccaag tgccaggaag aagtcagcca catccctgcc gtctacccgg gtgcgttccg      720

tcccaagtgc gacgagaacg gtaactattt gccactccag tgccacggga gcactggcta      780

ctgctggtgt gtgttcccca acggcactga ggttcctcac accaagagcc gcgggcgcca      840

taactgcagt gagccactgg acatggaaga cctatcttct ggcctgggag tgaccaggca      900

ggaactgggt caagtcaccc tgtgaagaca gaggccagct ctgcacagca gcagcgcccc      960

ctgctctcct gtgcctcagc ccttcttatg ttccctgatg tcacacccca cttcccgtct     1020

ccctgcaccc tggggcttga gactggtgtc tgtttcatcg tcccaggaca cggcaaatga     1080

agtcagaaca gaaggaggac gctggagggc cttgctggct accgctatct aaagggaacc     1140

cccatttctg acccattagt agtcttgaat gtggggctct gagataaagg cccgcagaca     1200

gggacaaggg atgccctacc cttaacctag gctggacaca tttgctgcct tctcctcaag     1260

gaagaagaac ccaagcccct cctcccagta acccctcctc acatcctgcc accccccctc     1320

aagccccacc ccctttcagg ttccttgctc agccaagctt gtcagcagcc tgtaggatca     1380

tggttcaagt gacaataaag gaagaaagta gaacaaaaaa aaaaaaaaaa a              1431


<210> 26
<211> 279
<212> PRT
<213> Mus musculus

<400> 26
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
1               5                   10                  15      


Leu Gly Asn Arg Pro Arg Glu Pro Glu Arg Cys Ser Arg Gly Ala Leu 
            20                  25                  30          


Tyr Thr Gly Val Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln Ala 
        35                  40                  45              


Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys Leu 
    50                  55                  60                  


Thr Ile Thr Ser Gln Asn Leu Gln Leu Glu Ser Leu Arg Met Lys Leu 
65                  70                  75                  80  


Pro Lys Ser Ala Lys Pro Val Ser Gln Met Arg Met Ala Thr Pro Leu 
                85                  90                  95      


Leu Met Arg Pro Met Ser Met Asp Asn Met Leu Leu Gly Pro Val Lys 
            100                 105                 110         


Asn Val Thr Lys Tyr Gly Asn Met Thr Gln Asp His Val Met His Leu 
        115                 120                 125             


Leu Thr Arg Ser Gly Pro Leu Glu Tyr Pro Gln Leu Lys Gly Thr Phe 
    130                 135                 140                 


Pro Glu Asn Leu Lys His Leu Lys Asn Ser Met Asp Gly Val Asn Trp 
145                 150                 155                 160 


Lys Ile Phe Glu Ser Trp Met Lys Gln Trp Leu Leu Phe Glu Met Ser 
                165                 170                 175     


Lys Asn Ser Leu Glu Glu Lys Lys Pro Thr Glu Ala Pro Pro Lys Val 
            180                 185                 190         


Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val Tyr Pro 
        195                 200                 205             


Gly Ala Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro Leu 
    210                 215                 220                 


Gln Cys His Gly Ser Thr Gly Tyr Cys Trp Cys Val Phe Pro Asn Gly 
225                 230                 235                 240 


Thr Glu Val Pro His Thr Lys Ser Arg Gly Arg His Asn Cys Ser Glu 
                245                 250                 255     


Pro Leu Asp Met Glu Asp Leu Ser Ser Gly Leu Gly Val Thr Arg Gln 
            260                 265                 270         


Glu Leu Gly Gln Val Thr Leu 
        275                 


<210> 27
<211> 1239
<212> DNA
<213> Mus musculus

<400> 27
agacacacag cagcagcagc agcagcagca gcagcaacag cagcagcagc agcagcgcct       60

gtgggaaaaa ctagaggcta gagccatgga tgaccaacgc gacctcatct ctaaccatga      120

acagttgccc atactgggca accgccctag agagccagaa aggtgcagcc gtggagctct      180

gtacaccggt gtctctgtcc tggtggctct gctcttggct gggcaggcca ccactgctta      240

cttcctgtac cagcaacagg gccgcctaga caagctgacc atcacctccc agaacctgca      300

actggagagc cttcgcatga agcttccgaa atctgccaaa cctgtgagcc agatgcggat      360

ggctactccc ttgctgatgc gtccaatgtc catggataac atgctccttg ggcctgtgaa      420

gaacgttacc aagtacggca acatgaccca ggaccatgtg atgcatctgc tcacgaggtc      480

tggacccctg gagtacccgc agctgaaggg gaccttccca gagaatctga agcatcttaa      540

gaactccatg gatggcgtga actggaagat cttcgagagc tggatgaagc agtggctctt      600

gtttgagatg agcaagaact ccctggagga gaagaagccc accgaggctc cacctaaaga      660

gccactggac atggaagacc tatcttctgg cctgggagtg accaggcagg aactgggtca      720

agtcaccctg tgaagacaga ggccagctct gcacagcagc agcgccccct gctctcctgt      780

gcctcagccc ttcttatgtt ccctgatgtc acaccccact tcccgtctcc ctgcaccctg      840

gggcttgaga ctggtgtctg tttcatcgtc ccaggacacg gcaaatgaag tcagaacaga      900

aggaggacgc tggagggcct tgctggctac cgctatctaa agggaacccc catttctgac      960

ccattagtag tcttgaatgt ggggctctga gataaaggcc cgcagacagg gacaagggat     1020

gccctaccct taacctaggc tggacacatt tgctgccttc tcctcaagga agaagaaccc     1080

aagcccctcc tcccagtaac ccctcctcac atcctgccac cccccctcaa gccccacccc     1140

ctttcaggtt ccttgctcag ccaagcttgt cagcagcctg taggatcatg gttcaagtga     1200

caataaagga agaaagtaga acaaaaaaaa aaaaaaaaa                            1239


<210> 28
<211> 215
<212> PRT
<213> Mus musculus

<400> 28
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
1               5                   10                  15      


Leu Gly Asn Arg Pro Arg Glu Pro Glu Arg Cys Ser Arg Gly Ala Leu 
            20                  25                  30          


Tyr Thr Gly Val Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln Ala 
        35                  40                  45              


Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys Leu 
    50                  55                  60                  


Thr Ile Thr Ser Gln Asn Leu Gln Leu Glu Ser Leu Arg Met Lys Leu 
65                  70                  75                  80  


Pro Lys Ser Ala Lys Pro Val Ser Gln Met Arg Met Ala Thr Pro Leu 
                85                  90                  95      


Leu Met Arg Pro Met Ser Met Asp Asn Met Leu Leu Gly Pro Val Lys 
            100                 105                 110         


Asn Val Thr Lys Tyr Gly Asn Met Thr Gln Asp His Val Met His Leu 
        115                 120                 125             


Leu Thr Arg Ser Gly Pro Leu Glu Tyr Pro Gln Leu Lys Gly Thr Phe 
    130                 135                 140                 


Pro Glu Asn Leu Lys His Leu Lys Asn Ser Met Asp Gly Val Asn Trp 
145                 150                 155                 160 


Lys Ile Phe Glu Ser Trp Met Lys Gln Trp Leu Leu Phe Glu Met Ser 
                165                 170                 175     


Lys Asn Ser Leu Glu Glu Lys Lys Pro Thr Glu Ala Pro Pro Lys Glu 
            180                 185                 190         


Pro Leu Asp Met Glu Asp Leu Ser Ser Gly Leu Gly Val Thr Arg Gln 
        195                 200                 205             


Glu Leu Gly Gln Val Thr Leu 
    210                 215 


<210> 29
<211> 1886
<212> DNA
<213> Homo sapiens

<400> 29
ggcagccaga agcacctgtg ctcccaggat aagggtgagc actcaggatg actgtggaga       60

aggaggcccc tgatgcgcac ttcactgtgg acaaacagaa catctccctc tggccccgag      120

agcctcctcc caagtccggt ccatctctgg tcccggggaa aacacccaca gtccgtgctg      180

cattaatctg cctgacgctg gtcctggtcg cctccgtcct gctgcaggcc gtcctttatc      240

cccggtttat gggcaccata tcagatgtaa agaccaatgt ccagttgctg aaaggtcgtg      300

tggacaacat cagcaccctg gattctgaaa ttaaaaagaa tagtgacggc atggaggcag      360

ctggcgttca gatccagatg gtgaatgaga gcctgggtta tgtgcgttct cagttcctga      420

agttaaaaac cagtgtggag aaggccaacg cacagatcca gatcttaaca agaagttggg      480

aagaagtcag taccttaaat gcccaaatcc cagagttaaa aagtgatttg gagaaagcca      540

gtgctttaaa tacaaagatc cgggcactcc agggcagctt ggagaatatg agcaagttgc      600

tcaaacgaca aaatgatatt ctacaggtgg tttctcaagg ctggaagtac ttcaagggga      660

acttctatta cttttctctc attccaaaga cctggtatag tgccgagcag ttctgtgtgt      720

ccaggaattc acacctgacc tcggtgacct cagagagtga gcaggagttt ctgtataaaa      780

cagcgggggg actcatctac tggattggcc tgactaaagc agggatggaa ggggactggt      840

cctgggtgga tgacacgcca ttcaacaagg tccaaagtgt gaggttctgg attccaggtg      900

agcccaacaa tgctgggaac aatgaacact gtggcaatat aaaggctccc tcacttcagg      960

cctggaatga tgccccatgt gacaaaacgt ttcttttcat ttgtaagcga ccctatgtcc     1020

catcagaacc gtgacaggac aggctcccaa gctcactctt tgagctccaa cgcttgttaa     1080

acatgaggaa atgcctcttt cttccccaga ctccaggatg actttgcacg ttaatttttc     1140

ttgcttcaaa attgtcccac agtggcattc tggagtccgt ctgtcttggc tggaaattct     1200

ctgacgtctt ggaggcagct ggaatggaaa ggagaattca ggttaaagtg ggaggggtgg     1260

gtagagagga tttagaagtt ccaattgccc tgctaaggag gatcaagacc cgtaatccgg     1320

cataacaccc tggggttttc cactctttca gagaaacctc agcttcatca catcaaagtt     1380

actccagagc aaccaagcaa ttctcctgat attgtcatcc agggcttttc ttggccaaac     1440

cccctagaat ttccatgtct ctgcttagct gtgctggcag ctagcagctg gctgtgtttg     1500

cagtgcaaat agctctgttc ttggaaatcc tgctcatggt atgtccccag tggtttcttc     1560

atccacatca tctaaagcct gaacccgttc ttctctggtt caagtcagtg gctgacacgg     1620

acttgtatct ccttcagagc tcggctggca cccagcctcc cttctccttc cactccctta     1680

gtacactgga gtgccgagcc ctgccttcca cccagcgtcc atccagcccc tgtcctcacc     1740

tctccggcac ctcctcctcc ttctgcattt cctatcttcc tgtgtcttgt gcatgggaag     1800

cagccttcag tgccttcatg aattcacctt ccagcttcct cagaataaaa tgctgcctgg     1860

gtcaaggact caaaaaaaaa aaaaaa                                          1886


<210> 30
<211> 328
<212> PRT
<213> Homo sapiens

<400> 30
Met Thr Val Glu Lys Glu Ala Pro Asp Ala His Phe Thr Val Asp Lys 
1               5                   10                  15      


Gln Asn Ile Ser Leu Trp Pro Arg Glu Pro Pro Pro Lys Ser Gly Pro 
            20                  25                  30          


Ser Leu Val Pro Gly Lys Thr Pro Thr Val Arg Ala Ala Leu Ile Cys 
        35                  40                  45              


Leu Thr Leu Val Leu Val Ala Ser Val Leu Leu Gln Ala Val Leu Tyr 
    50                  55                  60                  


Pro Arg Phe Met Gly Thr Ile Ser Asp Val Lys Thr Asn Val Gln Leu 
65                  70                  75                  80  


Leu Lys Gly Arg Val Asp Asn Ile Ser Thr Leu Asp Ser Glu Ile Lys 
                85                  90                  95      


Lys Asn Ser Asp Gly Met Glu Ala Ala Gly Val Gln Ile Gln Met Val 
            100                 105                 110         


Asn Glu Ser Leu Gly Tyr Val Arg Ser Gln Phe Leu Lys Leu Lys Thr 
        115                 120                 125             


Ser Val Glu Lys Ala Asn Ala Gln Ile Gln Ile Leu Thr Arg Ser Trp 
    130                 135                 140                 


Glu Glu Val Ser Thr Leu Asn Ala Gln Ile Pro Glu Leu Lys Ser Asp 
145                 150                 155                 160 


Leu Glu Lys Ala Ser Ala Leu Asn Thr Lys Ile Arg Ala Leu Gln Gly 
                165                 170                 175     


Ser Leu Glu Asn Met Ser Lys Leu Leu Lys Arg Gln Asn Asp Ile Leu 
            180                 185                 190         


Gln Val Val Ser Gln Gly Trp Lys Tyr Phe Lys Gly Asn Phe Tyr Tyr 
        195                 200                 205             


Phe Ser Leu Ile Pro Lys Thr Trp Tyr Ser Ala Glu Gln Phe Cys Val 
    210                 215                 220                 


Ser Arg Asn Ser His Leu Thr Ser Val Thr Ser Glu Ser Glu Gln Glu 
225                 230                 235                 240 


Phe Leu Tyr Lys Thr Ala Gly Gly Leu Ile Tyr Trp Ile Gly Leu Thr 
                245                 250                 255     


Lys Ala Gly Met Glu Gly Asp Trp Ser Trp Val Asp Asp Thr Pro Phe 
            260                 265                 270         


Asn Lys Val Gln Ser Val Arg Phe Trp Ile Pro Gly Glu Pro Asn Asn 
        275                 280                 285             


Ala Gly Asn Asn Glu His Cys Gly Asn Ile Lys Ala Pro Ser Leu Gln 
    290                 295                 300                 


Ala Trp Asn Asp Ala Pro Cys Asp Lys Thr Phe Leu Phe Ile Cys Lys 
305                 310                 315                 320 


Arg Pro Tyr Val Pro Ser Glu Pro 
                325             


<210> 31
<211> 1530
<212> DNA
<213> Mus musculus

<400> 31
tttcccgttt ctttctggat aaaaaggtcc ttggggagac agatattgag aatttcctat       60

gccagaggca gagatgaagg aggaggctcc cgaagcgcac ttcacagtgg acaaacagaa      120

catctctctc tggcctcgag agcctcctcc caagcaagat ctgtctccag ttctaaggaa      180

acctctctgt atctgcgtgg ccttcacctg cctggcattg gtgctggtca cctccattgt      240

gcttcaggct gttttctatc ctaggttgat gggcaaaata ttggatgtga agagtgatgc      300

ccagatgttg aaaggtcgtg tggacaacat cagcaccctg ggttctgatc ttaagactga      360

aagaggtcgt gtggacgatg ctgaggttca gatgcagata gtgaacacca ccctcaagag      420

ggtgcgttct cagatcctgt ctttggaaac cagcatgaag atagccaatg atcagctcca      480

gatattaaca atgagctggg gagaggttga cagtctcagt gccaaaatcc cagaactgaa      540

aagagatctg gataaagcca gcgccttgaa cacaaaggtc caaggactac agaacagctt      600

ggagaatgtc aacaagctgc tcaaacaaca gagtgacatt ctggagatgg tggctcgagg      660

ctggaagtat ttctcgggga acttctatta cttttcacgc accccaaaga cctggtacag      720

cgcagagcag ttctgtattt ctagaaaagc tcacctgacc tcagtgtcct cagaatcgga      780

acaaaagttt ctctacaagg cagcagatgg aattccacac tggattggac ttaccaaagc      840

agggagcgaa ggggactggt actgggtgga ccagacatca ttcaacaagg agcaaagtag      900

gaggttctgg attccaggtg aacccaacaa cgcagggaac aatgagcact gtgccaatat      960

cagggtgtct gccctgaagt gctggaacga tggtccctgt gacaatacat ttcttttcat     1020

ctgcaagagg ccctacgtcc aaacaactga atgacagatc tggcctgagc tcggcatctg     1080

tggggcaaca gtgacctggc tgaagagatg tctctctccc tgaggctcca agattgctct     1140

gtactttacg tttttttctt gcttgaaaat tgtcccaaac acagcctgtg gtctttctgt     1200

cttggctggc agttctctgc tcctggaggc cttggaggag cttgggttaa acgggtgagg     1260

acctgaagag ggcgtagcag tccttactgc ccaggcgagg caggtcagca caccaaacag     1320

gttgtttaga ttttcctgat ccttctcaga agccttggct gaccatataa aagctacatt     1380

caaatatgac cagtatttga ggaggcagac atgcccaaat ttaaccatga tacaatttat     1440

acaacatgta ttagaacacc tcatggtatg ctcaaaatat gtaaatatgt tgtttttatg     1500

tgcctattgc aaataaatgt aatattacta                                      1530


<210> 32
<211> 331
<212> PRT
<213> Mus musculus

<400> 32
Met Pro Glu Ala Glu Met Lys Glu Glu Ala Pro Glu Ala His Phe Thr 
1               5                   10                  15      


Val Asp Lys Gln Asn Ile Ser Leu Trp Pro Arg Glu Pro Pro Pro Lys 
            20                  25                  30          


Gln Asp Leu Ser Pro Val Leu Arg Lys Pro Leu Cys Ile Cys Val Ala 
        35                  40                  45              


Phe Thr Cys Leu Ala Leu Val Leu Val Thr Ser Ile Val Leu Gln Ala 
    50                  55                  60                  


Val Phe Tyr Pro Arg Leu Met Gly Lys Ile Leu Asp Val Lys Ser Asp 
65                  70                  75                  80  


Ala Gln Met Leu Lys Gly Arg Val Asp Asn Ile Ser Thr Leu Gly Ser 
                85                  90                  95      


Asp Leu Lys Thr Glu Arg Gly Arg Val Asp Asp Ala Glu Val Gln Met 
            100                 105                 110         


Gln Ile Val Asn Thr Thr Leu Lys Arg Val Arg Ser Gln Ile Leu Ser 
        115                 120                 125             


Leu Glu Thr Ser Met Lys Ile Ala Asn Asp Gln Leu Gln Ile Leu Thr 
    130                 135                 140                 


Met Ser Trp Gly Glu Val Asp Ser Leu Ser Ala Lys Ile Pro Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Asp Lys Ala Ser Ala Leu Asn Thr Lys Val Gln Gly 
                165                 170                 175     


Leu Gln Asn Ser Leu Glu Asn Val Asn Lys Leu Leu Lys Gln Gln Ser 
            180                 185                 190         


Asp Ile Leu Glu Met Val Ala Arg Gly Trp Lys Tyr Phe Ser Gly Asn 
        195                 200                 205             


Phe Tyr Tyr Phe Ser Arg Thr Pro Lys Thr Trp Tyr Ser Ala Glu Gln 
    210                 215                 220                 


Phe Cys Ile Ser Arg Lys Ala His Leu Thr Ser Val Ser Ser Glu Ser 
225                 230                 235                 240 


Glu Gln Lys Phe Leu Tyr Lys Ala Ala Asp Gly Ile Pro His Trp Ile 
                245                 250                 255     


Gly Leu Thr Lys Ala Gly Ser Glu Gly Asp Trp Tyr Trp Val Asp Gln 
            260                 265                 270         


Thr Ser Phe Asn Lys Glu Gln Ser Arg Arg Phe Trp Ile Pro Gly Glu 
        275                 280                 285             


Pro Asn Asn Ala Gly Asn Asn Glu His Cys Ala Asn Ile Arg Val Ser 
    290                 295                 300                 


Ala Leu Lys Cys Trp Asn Asp Gly Pro Cys Asp Asn Thr Phe Leu Phe 
305                 310                 315                 320 


Ile Cys Lys Arg Pro Tyr Val Gln Thr Thr Glu 
                325                 330     


<210> 33
<211> 2430
<212> DNA
<213> Homo sapiens

<400> 33
gccagaggaa cgccagcgac cccagcagcg ctgcggacgg tgctggccgt ggccgctgcg       60

gcccccgtgt ccaggtgggc caggacgcag cctctgggcg ccgtcgcttt tccagcatcg      120

cagaggcaaa agcgtggcag tgggacccaa aaggtaggac tgaggctcta gaacttgcac      180

ctgtgcaggg actgcaaacc agacctggga ggaccctttc agcagccccc actccaccct      240

atcccaggac ttcccagcga cccgccgttc tgggagatac cgggagcgtg atcagggggc      300

ggggccgttt ccaaggcaac cgcttatttg catagggtcc cgtcctggcc aacgagggcg      360

ccccaaatgt tcaggacata gaagaagggg ttaactggcc cggatctcct cctcgccttc      420

caagcccgct aagcactggg gttatctacc cattccccag aaggggagac tgaggcagcc      480

caccagccaa aggaggcgac cagactgggg ctgcgtttta ccatttcaga agcggcttga      540

gctggtctga gctataataa taaacactgg cggtggaggc gagggcgacc acagggctga      600

ggtcagggct aggattccgg tgtctctacg taggttgctt gaatgggggg caccctggca      660

tggacgctgc tgttgccgct gctgctgcgg gagtcagaca gcctagaacc gtcgtgcacc      720

gtgtcctccg cggatgtgga ctggaacgcg gagttcagtg ccacgtgcct gaatttcagt      780

ggcctcagcc tgagcctgcc tcacaaccag tctctgcggg ccagcaacgt gattctcctt      840

gacctgtctg ggaacggcct gcgagagctt ccagtgacct tctttgccca cctgcagaag      900

cttgaggtcc tgaacgtgct acgcaacccc ttgtctcgtg tggatggggc gctggccgcc      960

cgctgtgacc ttgacctgca ggccgactgc aactgtgccc tggagtcctg gcacgacatc     1020

cgccgagaca actgctctgg ccagaagcct ctgctctgct gggacacaac cagctcccag     1080

cacaacctct ctgccttcct ggaggtcagc tgcgcccctg gcctggcctc tgcaactatc     1140

ggggcagtgg tggtcagcgg gtgcctgctt cttggacttg ccatcgctgg ccctgtgctg     1200

gcctggagac tctggcgatg ccgagtggcc agaagccggg agctgaacaa accctgggct     1260

gctcaggatg ggcccaagcc cggtttaggc ttgcagccac ggtacggcag ccggagcgcc     1320

cccaagcccc aagtggccgt gccatcctgc ccctccactc ccgactatga gaacatgttt     1380

gtgggccagc cagcagccga gcaccagtgg gatgaacaag gggctcaccc ttcagaggac     1440

aatgactttt acatcaacta caaggacatc gacctggctt cccagcctgt ctactgtaac     1500

ctgcagtcac tgggccaggc cccaatggat gaagaggagt acgtgatccc cgggcactga     1560

gcctaagatg tcctaacctc cacccagaac cccttcagtc cctgctgggt gactcagggc     1620

gtcctaacgc ctccatggcc tcagtttccc catctgaaga atgggtacag gaaaggattg     1680

tccttgaggc cccaggaagc tctgccgccc cctccctgtc cctcatgccg ctcctcagct     1740

ccctcagctc ctagaggggg aagaggagag acccccaaca aggggacagg acggtcactg     1800

tgccaatcct gtcatcaccc tcctgtggat gtacaggcag tgctcaataa atgcttcgag     1860

gctgatgagg ctgctggctc agggtgcgtg ggttcctcaa ggtggggatt tctgagttct     1920

aagaccaagt ctccatctga gactcccaaa ttgctcccca cctcccatcc ctgttttttt     1980

ttgttgttgt tgtttgtttg tttgtttttg aaactgagtg tcactctgtc acccaggctg     2040

gagtgcaatg ctgcggtctc agctcactgc aacctccgcc tcctgggttc aagtgattct     2100

cctgcctcag cctcctgagt agctgggatt acagcacccg ccaccatgcc gagctaattt     2160

ttgtatttat aatagagatg gggtttcgcc atgttggcca ggctggtctc gaactcctga     2220

cctcaagcga tctgcccgcc tcggcctcct gaagtgctgg gattacaggc gtggccactg     2280

cgcccaggca cattcctccc ttctgcccct ctcagggccc cttcccaggt ccctgatctc     2340

caggcttggc ctccagagca gcccacacca accccaaaat aaaaaaatgt atatattcct     2400

ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      2430


<210> 34
<211> 305
<212> PRT
<213> Homo sapiens

<400> 34
Met Gly Gly Thr Leu Ala Trp Thr Leu Leu Leu Pro Leu Leu Leu Arg 
1               5                   10                  15      


Glu Ser Asp Ser Leu Glu Pro Ser Cys Thr Val Ser Ser Ala Asp Val 
            20                  25                  30          


Asp Trp Asn Ala Glu Phe Ser Ala Thr Cys Leu Asn Phe Ser Gly Leu 
        35                  40                  45              


Ser Leu Ser Leu Pro His Asn Gln Ser Leu Arg Ala Ser Asn Val Ile 
    50                  55                  60                  


Leu Leu Asp Leu Ser Gly Asn Gly Leu Arg Glu Leu Pro Val Thr Phe 
65                  70                  75                  80  


Phe Ala His Leu Gln Lys Leu Glu Val Leu Asn Val Leu Arg Asn Pro 
                85                  90                  95      


Leu Ser Arg Val Asp Gly Ala Leu Ala Ala Arg Cys Asp Leu Asp Leu 
            100                 105                 110         


Gln Ala Asp Cys Asn Cys Ala Leu Glu Ser Trp His Asp Ile Arg Arg 
        115                 120                 125             


Asp Asn Cys Ser Gly Gln Lys Pro Leu Leu Cys Trp Asp Thr Thr Ser 
    130                 135                 140                 


Ser Gln His Asn Leu Ser Ala Phe Leu Glu Val Ser Cys Ala Pro Gly 
145                 150                 155                 160 


Leu Ala Ser Ala Thr Ile Gly Ala Val Val Val Ser Gly Cys Leu Leu 
                165                 170                 175     


Leu Gly Leu Ala Ile Ala Gly Pro Val Leu Ala Trp Arg Leu Trp Arg 
            180                 185                 190         


Cys Arg Val Ala Arg Ser Arg Glu Leu Asn Lys Pro Trp Ala Ala Gln 
        195                 200                 205             


Asp Gly Pro Lys Pro Gly Leu Gly Leu Gln Pro Arg Tyr Gly Ser Arg 
    210                 215                 220                 


Ser Ala Pro Lys Pro Gln Val Ala Val Pro Ser Cys Pro Ser Thr Pro 
225                 230                 235                 240 


Asp Tyr Glu Asn Met Phe Val Gly Gln Pro Ala Ala Glu His Gln Trp 
                245                 250                 255     


Asp Glu Gln Gly Ala His Pro Ser Glu Asp Asn Asp Phe Tyr Ile Asn 
            260                 265                 270         


Tyr Lys Asp Ile Asp Leu Ala Ser Gln Pro Val Tyr Cys Asn Leu Gln 
        275                 280                 285             


Ser Leu Gly Gln Ala Pro Met Asp Glu Glu Glu Tyr Val Ile Pro Gly 
    290                 295                 300                 


His 
305 


<210> 35
<211> 1273
<212> DNA
<213> Mus musculus

<400> 35
ctcctcctct cgtgagagcc tgaggctggc agagggctct ctgctgtccc ctccactcct       60

acacctactc gtcttcccgt cttcccgcag gcgtggatta acaggtggaa agcaccagga      120

gctgtgaacc ccaacccaga ccctaggacc ctgaggctta cgagacatca cgaaggccag      180

gaggttgctg ggatgggaag catcagaact aggttgctgt ggttatgtct cctgatgctg      240

ttggccctgc ttcacaagtc aggaagtcaa gatctcacct gcatggttca cccgagcagg      300

gtagactgga ctcagacatt taatggcacc tgcctcaatt tcagtggcct tggcctgtcc      360

ctgccaagga gccccttgca ggccagccat gctcaagtcc tggacctgtc taagaatggc      420

ctgcaggtgc tccctggggc tttcttcgac aagctggaaa agctgcagac cctgattgtc      480

acccacaacc agctggacag tgtggacagg tccctggcct tgcgctgtga cctggagctc      540

aaggcagact gcagctgtgg gctggcctcc tggtatgctc tccgccagaa ctgctccggg      600

cagcagcagc tactgtgtct acacccagcc accgaagctc caaggaacct ctccaccttc      660

cttcaggtca gctgtccccc cagctggggc ccggggacca ttggagccct tgttgctggg      720

actatctccc tggctgtggc tgtcagtgga tctgtgctgg cctggagact tcttcgccgc      780

cgccgcagag ccagtgagca cagcctcagc aaagcccaga tgtccccaca cgatatcccc      840

aaaccagtga cagatttcct gccaaggtac agcagccggc gacctggccc caaggcccca      900

gactcaccac ccagcaggtt cacaatggat tatgagaatg tctttattgg ccagccggcc      960

gaggactgct catggtctgc agccagaaac agcccttctg gggacagtga ctgctacatg     1020

aactacagga gtgtcgacca ggactctcag cccgtctatt gcaacctgga gtccctgggg     1080

cgatgaggag agtgtggtct cctggcgctg aaccagcctc cgacagcccc caggatccag     1140

cacgctcaac atcacagggg gtagaggaca ccccaccccc ccacccccaa agcagaagga     1200

gggtcagaaa caaccctccg gtcagtgtgc atgcatgtga tgctcaataa aagctctggg     1260

agcagctgac tct                                                        1273


<210> 36
<211> 297
<212> PRT
<213> Mus musculus

<400> 36
Met Gly Ser Ile Arg Thr Arg Leu Leu Trp Leu Cys Leu Leu Met Leu 
1               5                   10                  15      


Leu Ala Leu Leu His Lys Ser Gly Ser Gln Asp Leu Thr Cys Met Val 
            20                  25                  30          


His Pro Ser Arg Val Asp Trp Thr Gln Thr Phe Asn Gly Thr Cys Leu 
        35                  40                  45              


Asn Phe Ser Gly Leu Gly Leu Ser Leu Pro Arg Ser Pro Leu Gln Ala 
    50                  55                  60                  


Ser His Ala Gln Val Leu Asp Leu Ser Lys Asn Gly Leu Gln Val Leu 
65                  70                  75                  80  


Pro Gly Ala Phe Phe Asp Lys Leu Glu Lys Leu Gln Thr Leu Ile Val 
                85                  90                  95      


Thr His Asn Gln Leu Asp Ser Val Asp Arg Ser Leu Ala Leu Arg Cys 
            100                 105                 110         


Asp Leu Glu Leu Lys Ala Asp Cys Ser Cys Gly Leu Ala Ser Trp Tyr 
        115                 120                 125             


Ala Leu Arg Gln Asn Cys Ser Gly Gln Gln Gln Leu Leu Cys Leu His 
    130                 135                 140                 


Pro Ala Thr Glu Ala Pro Arg Asn Leu Ser Thr Phe Leu Gln Val Ser 
145                 150                 155                 160 


Cys Pro Pro Ser Trp Gly Pro Gly Thr Ile Gly Ala Leu Val Ala Gly 
                165                 170                 175     


Thr Ile Ser Leu Ala Val Ala Val Ser Gly Ser Val Leu Ala Trp Arg 
            180                 185                 190         


Leu Leu Arg Arg Arg Arg Arg Ala Ser Glu His Ser Leu Ser Lys Ala 
        195                 200                 205             


Gln Met Ser Pro His Asp Ile Pro Lys Pro Val Thr Asp Phe Leu Pro 
    210                 215                 220                 


Arg Tyr Ser Ser Arg Arg Pro Gly Pro Lys Ala Pro Asp Ser Pro Pro 
225                 230                 235                 240 


Ser Arg Phe Thr Met Asp Tyr Glu Asn Val Phe Ile Gly Gln Pro Ala 
                245                 250                 255     


Glu Asp Cys Ser Trp Ser Ala Ala Arg Asn Ser Pro Ser Gly Asp Ser 
            260                 265                 270         


Asp Cys Tyr Met Asn Tyr Arg Ser Val Asp Gln Asp Ser Gln Pro Val 
        275                 280                 285             


Tyr Cys Asn Leu Glu Ser Leu Gly Arg 
    290                 295         


<210> 37
<211> 2638
<212> DNA
<213> Homo sapiens

<400> 37
aatcatccga gaaccttgga gggtggacag tgcccctttt acagatgaga aaactgaggc       60

ttgaagggga gaagcagctg cctctggcgg catggcttct ggctgcagga tgcccatgga      120

gttcgtggtg accctaggcc tgtgtctcgg cttcctttgc tgaacttgaa caggaagatg      180

gcagtggggg ccagtggtct agaaggagat aagatggctg gtgccatgcc tctgcaactc      240

ctcctgttgc tgatcctact gggccctggc aacagcttgc agctgtggga cacctgggca      300

gatgaagccg agaaagcctt gggtcccctg cttgcccggg accggagaca ggccaccgaa      360

tatgagtacc tagattatga tttcctgcca gaaacggagc ctccagaaat gctgaggaac      420

agcactgaca ccactcctct gactgggcct ggaacccctg agtctaccac tgtggagcct      480

gctgcaaggc gttctactgg cctggatgca ggaggggcag tcacagagct gaccacggag      540

ctggccaaca tggggaacct gtccacggat tcagcagcta tggagataca gaccactcaa      600

ccagcagcca cggaggcaca gaccactcaa ccagtgccca cggaggcaca gaccactcca      660

ctggcagcca cagaggcaca gacaactcga ctgacggcca cggaggcaca gaccactcca      720

ctggcagcca cagaggcaca gaccactcca ccagcagcca cggaagcaca gaccactcaa      780

cccacaggcc tggaggcaca gaccactgca ccagcagcca tggaggcaca gaccactgca      840

ccagcagcca tggaagcaca gaccactcca ccagcagcca tggaggcaca gaccactcaa      900

accacagcca tggaggcaca gaccactgca ccagaagcca cggaggcaca gaccactcaa      960

cccacagcca cggaggcaca gaccactcca ctggcagcca tggaggccct gtccacagaa     1020

cccagtgcca cagaggccct gtccatggaa cctactacca aaagaggtct gttcataccc     1080

ttttctgtgt cctctgttac tcacaagggc attcccatgg cagccagcaa tttgtccgtc     1140

aactacccag tgggggcccc agaccacatc tctgtgaagc agtgcctgct ggccatccta     1200

atcttggcgc tggtggccac tatcttcttc gtgtgcactg tggtgctggc ggtccgcctc     1260

tcccgcaagg gccacatgta ccccgtgcgt aattactccc ccaccgagat ggtctgcatc     1320

tcatccctgt tgcctgatgg gggtgagggg ccctctgcca cagccaatgg gggcctgtcc     1380

aaggccaaga gcccgggcct gacgccagag cccagggagg accgtgaggg ggatgacctc     1440

accctgcaca gcttcctccc ttagctcact ctgccatctg ttttggcaag accccacctc     1500

cacgggctct cctgggccac ccctgagtgc ccagacccca ttccacagct ctgggcttcc     1560

tcggagaccc ctggggatgg ggatcttcag ggaaggaact ctggccaccc aaacaggaca     1620

agagcagcct ggggccaagc agacgggcaa gtggagccac ctctttcctc cctccgcgga     1680

tgaagcccag ccacatttca gccgaggtcc aaggcaggag gccatttact tgagacagat     1740

tctctccttt ttcctgtccc ccatcttctc tgggtccctc taacatctcc catggctctc     1800

cccgcttctc ctggtcactg gagtctcctc cccatgtacc caaggaagat ggagctcccc     1860

catcccacac gcactgcact gccattgtct tttggttgcc atggtcacca aacaggaagt     1920

ggacattcta agggaggagt actgaagagt gacggacttc tgaggctgtt tcctgctgct     1980

cctctgactt ggggcagctt gggtcttctt gggcacctct ctgggaaaac ccagggtgag     2040

gttcagcctg tgagggctgg gatgggtttc gtgggcccaa gggcagacct ttctttggga     2100

ctgtgtggac caaggagctt ccatctagtg acaagtgacc cccagctatc gcctcttgcc     2160

ttcccctgtg gccactttcc agggtggact ctgtcttgtt cactgcagta tcccaactgc     2220

aggtccagtg caggcaataa atatgtgatg gacaaacgat agcggaatcc ttcaaggttt     2280

caaggctgtc tccttcaggc agccttcccg gaattctcca tccctcagtg caggatgggg     2340

gctggtcctc agctgtctgc cctcagcccc tggcccccca ggaagcctct ttcatgggct     2400

gttaggttga cttcagtttt gcctcttgga caacaggggg tcttgtacat ccttgggtga     2460

ccaggaaaag ttcaggctat ggggggccaa agggagggct gccccttccc caccagtgac     2520

cactttattc cacttcctcc attacccagt tttggcccac agagtttggt cccccccaaa     2580

cctcggacca atatccctct aaacatcaat ctatcctcct gttaaagaaa aaaaaaaa       2638


<210> 38
<211> 428
<212> PRT
<213> Homo sapiens

<400> 38
Met Ala Val Gly Ala Ser Gly Leu Glu Gly Asp Lys Met Ala Gly Ala 
1               5                   10                  15      


Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn 
            20                  25                  30          


Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu 
        35                  40                  45              


Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr 
    50                  55                  60                  


Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg 
65                  70                  75                  80  


Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser 
                85                  90                  95      


Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly 
            100                 105                 110         


Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu 
        115                 120                 125             


Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala 
    130                 135                 140                 


Thr Glu Ala Gln Thr Thr Gln Pro Val Pro Thr Glu Ala Gln Thr Thr 
145                 150                 155                 160 


Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Arg Leu Thr Ala Thr Glu 
                165                 170                 175     


Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Pro Pro 
            180                 185                 190         


Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Gly Leu Glu Ala Gln 
        195                 200                 205             


Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Ala Pro Ala Ala 
    210                 215                 220                 


Met Glu Ala Gln Thr Thr Pro Pro Ala Ala Met Glu Ala Gln Thr Thr 
225                 230                 235                 240 


Gln Thr Thr Ala Met Glu Ala Gln Thr Thr Ala Pro Glu Ala Thr Glu 
                245                 250                 255     


Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu 
            260                 265                 270         


Ala Ala Met Glu Ala Leu Ser Thr Glu Pro Ser Ala Thr Glu Ala Leu 
        275                 280                 285             


Ser Met Glu Pro Thr Thr Lys Arg Gly Leu Phe Ile Pro Phe Ser Val 
    290                 295                 300                 


Ser Ser Val Thr His Lys Gly Ile Pro Met Ala Ala Ser Asn Leu Ser 
305                 310                 315                 320 


Val Asn Tyr Pro Val Gly Ala Pro Asp His Ile Ser Val Lys Gln Cys 
                325                 330                 335     


Leu Leu Ala Ile Leu Ile Leu Ala Leu Val Ala Thr Ile Phe Phe Val 
            340                 345                 350         


Cys Thr Val Val Leu Ala Val Arg Leu Ser Arg Lys Gly His Met Tyr 
        355                 360                 365             


Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val Cys Ile Ser Ser Leu 
    370                 375                 380                 


Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr Ala Asn Gly Gly Leu 
385                 390                 395                 400 


Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu Pro Arg Glu Asp Arg 
                405                 410                 415     


Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu Pro 
            420                 425             


<210> 39
<211> 2573
<212> DNA
<213> Homo sapiens

<400> 39
acacacagcc attgggggtt gctcggatcc gggactgccg cagggggtgc cacagcagtg       60

cctggcagcg tgggctggga ccttgtcact aaagcagaga agccacttct tctgggccca      120

cgaggcagct gtcccatgct ctgctgagca cggtggtgcc atgcctctgc aactcctcct      180

gttgctgatc ctactgggcc ctggcaacag cttgcagctg tgggacacct gggcagatga      240

agccgagaaa gccttgggtc ccctgcttgc ccgggaccgg agacaggcca ccgaatatga      300

gtacctagat tatgatttcc tgccagaaac ggagcctcca gaaatgctga ggaacagcac      360

tgacaccact cctctgactg ggcctggaac ccctgagtct accactgtgg agcctgctgc      420

aaggcgttct actggcctgg atgcaggagg ggcagtcaca gagctgacca cggagctggc      480

caacatgggg aacctgtcca cggattcagc agctatggag atacagacca ctcaaccagc      540

agccacggag gcacagacca ctcaaccagt gcccacggag gcacagacca ctccactggc      600

agccacagag gcacagacaa ctcgactgac ggccacggag gcacagacca ctccactggc      660

agccacagag gcacagacca ctccaccagc agccacggaa gcacagacca ctcaacccac      720

aggcctggag gcacagacca ctgcaccagc agccatggag gcacagacca ctgcaccagc      780

agccatggaa gcacagacca ctccaccagc agccatggag gcacagacca ctcaaaccac      840

agccatggag gcacagacca ctgcaccaga agccacggag gcacagacca ctcaacccac      900

agccacggag gcacagacca ctccactggc agccatggag gccctgtcca cagaacccag      960

tgccacagag gccctgtcca tggaacctac taccaaaaga ggtctgttca tacccttttc     1020

tgtgtcctct gttactcaca agggcattcc catggcagcc agcaatttgt ccgtcaacta     1080

cccagtgggg gccccagacc acatctctgt gaagcagtgc ctgctggcca tcctaatctt     1140

ggcgctggtg gccactatct tcttcgtgtg cactgtggtg ctggcggtcc gcctctcccg     1200

caagggccac atgtaccccg tgcgtaatta ctcccccacc gagatggtct gcatctcatc     1260

cctgttgcct gatgggggtg aggggccctc tgccacagcc aatgggggcc tgtccaaggc     1320

caagagcccg ggcctgacgc cagagcccag ggaggaccgt gagggggatg acctcaccct     1380

gcacagcttc ctcccttagc tcactctgcc atctgttttg gcaagacccc acctccacgg     1440

gctctcctgg gccacccctg agtgcccaga ccccattcca cagctctggg cttcctcgga     1500

gacccctggg gatggggatc ttcagggaag gaactctggc cacccaaaca ggacaagagc     1560

agcctggggc caagcagacg ggcaagtgga gccacctctt tcctccctcc gcggatgaag     1620

cccagccaca tttcagccga ggtccaaggc aggaggccat ttacttgaga cagattctct     1680

cctttttcct gtcccccatc ttctctgggt ccctctaaca tctcccatgg ctctccccgc     1740

ttctcctggt cactggagtc tcctccccat gtacccaagg aagatggagc tcccccatcc     1800

cacacgcact gcactgccat tgtcttttgg ttgccatggt caccaaacag gaagtggaca     1860

ttctaaggga ggagtactga agagtgacgg acttctgagg ctgtttcctg ctgctcctct     1920

gacttggggc agcttgggtc ttcttgggca cctctctggg aaaacccagg gtgaggttca     1980

gcctgtgagg gctgggatgg gtttcgtggg cccaagggca gacctttctt tgggactgtg     2040

tggaccaagg agcttccatc tagtgacaag tgacccccag ctatcgcctc ttgccttccc     2100

ctgtggccac tttccagggt ggactctgtc ttgttcactg cagtatccca actgcaggtc     2160

cagtgcaggc aataaatatg tgatggacaa acgatagcgg aatccttcaa ggtttcaagg     2220

ctgtctcctt caggcagcct tcccggaatt ctccatccct cagtgcagga tgggggctgg     2280

tcctcagctg tctgccctca gcccctggcc ccccaggaag cctctttcat gggctgttag     2340

gttgacttca gttttgcctc ttggacaaca gggggtcttg tacatccttg ggtgaccagg     2400

aaaagttcag gctatggggg gccaaaggga gggctgcccc ttccccacca gtgaccactt     2460

tattccactt cctccattac ccagttttgg cccacagagt ttggtccccc ccaaacctcg     2520

gaccaatatc cctctaaaca tcaatctatc ctcctgttaa agaaaaaaaa aaa            2573


<210> 40
<211> 412
<212> PRT
<213> Homo sapiens

<400> 40
Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn 
1               5                   10                  15      


Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu 
            20                  25                  30          


Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr 
        35                  40                  45              


Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg 
    50                  55                  60                  


Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser 
65                  70                  75                  80  


Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly 
                85                  90                  95      


Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu 
            100                 105                 110         


Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala 
        115                 120                 125             


Thr Glu Ala Gln Thr Thr Gln Pro Val Pro Thr Glu Ala Gln Thr Thr 
    130                 135                 140                 


Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Arg Leu Thr Ala Thr Glu 
145                 150                 155                 160 


Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Pro Pro 
                165                 170                 175     


Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Gly Leu Glu Ala Gln 
            180                 185                 190         


Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Ala Pro Ala Ala 
        195                 200                 205             


Met Glu Ala Gln Thr Thr Pro Pro Ala Ala Met Glu Ala Gln Thr Thr 
    210                 215                 220                 


Gln Thr Thr Ala Met Glu Ala Gln Thr Thr Ala Pro Glu Ala Thr Glu 
225                 230                 235                 240 


Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu 
                245                 250                 255     


Ala Ala Met Glu Ala Leu Ser Thr Glu Pro Ser Ala Thr Glu Ala Leu 
            260                 265                 270         


Ser Met Glu Pro Thr Thr Lys Arg Gly Leu Phe Ile Pro Phe Ser Val 
        275                 280                 285             


Ser Ser Val Thr His Lys Gly Ile Pro Met Ala Ala Ser Asn Leu Ser 
    290                 295                 300                 


Val Asn Tyr Pro Val Gly Ala Pro Asp His Ile Ser Val Lys Gln Cys 
305                 310                 315                 320 


Leu Leu Ala Ile Leu Ile Leu Ala Leu Val Ala Thr Ile Phe Phe Val 
                325                 330                 335     


Cys Thr Val Val Leu Ala Val Arg Leu Ser Arg Lys Gly His Met Tyr 
            340                 345                 350         


Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val Cys Ile Ser Ser Leu 
        355                 360                 365             


Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr Ala Asn Gly Gly Leu 
    370                 375                 380                 


Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu Pro Arg Glu Asp Arg 
385                 390                 395                 400 


Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu Pro 
                405                 410         


<210> 41
<211> 2604
<212> DNA
<213> Mus musculus

<400> 41
attctcgctt ccttcttcca caccctgccg ttgggggttg gcgggcagat tgggaccaca       60

agtgtctggc agtgtggact ggggccctgt cactgaggca gagtcgtttg cttctgggcc      120

ctgaggcagc tgccccatgc tctgttgggc acggtaccat gtccccaagc ttccttgtgc      180

tgctgaccat cttgggccct ggcaacagcc ttcagctgca ggacccctgg gggcatgaaa      240

ccaaggaagc cccgggtcct gtgcatctcc gggaacggag gcaggtggtt ggggatgacg      300

attttgagga ccctgactat acgtataaca cagacccccc agaattgctg aaaaatgtca      360

ccaacaccgt ggctgctcac cctgagctgc caaccaccgt ggtcatgcta gagagagatt      420

ccacgagcgc tggaacctcc gagagagcca ctgagaagat tgccaccact gaccctactg      480

ccccaggtac aggagggaca gctgttggga tgctgagcac agactctgcc acacagtgga      540

gtctaacctc agtagagacc gtccaaccag catccacaga ggtagagacc tcgcagccag      600

cacccatgga ggcagagacc tcgcagccag cacccatgga ggcagagacc tcgcagccag      660

cacccatgga ggcagagacc tcgcagccag cacccatgga ggcagacacc tcgcagccag      720

cacccatgga ggcagacacc tcaaagccag cacccacgga ggcagagacc tcaaagccag      780

cacccacgga ggcagagacc tctcagccag cacccaacga ggcagagacc tcaaaaccag      840

cacccacgga ggcagagacc tcaaaaccag cacccacgga ggcagagacc acccagcttc      900

ccaggattca ggctgtaaaa actctgttta caacgtctgc agccaccgaa gtcccttcca      960

cagaacctac caccatggag acggcgtcca cagagtctaa cgagtctacc atcttccttg     1020

ggccatccgt gactcactta cctgacagcg gcctgaagaa agggctgatt gtgacccctg     1080

ggaattcacc tgccccaacc ctgccaggga gttcagatct catcccggtg aagcaatgtc     1140

tgctgattat cctcatcttg gcttctctgg ccaccatctt cctcgtgtgc acagtggtgc     1200

tggcggtccg tctgtcccgt aagacccaca tgtacccagt gcggaactac tcccccacgg     1260

agatgatctg catctcgtcc ctgctacctg aggggggaga cggggcccct gtcacagcca     1320

atgggggcct gcccaaggtc caggacctga agacagagcc cagtggggac cgggatgggg     1380

acgacctcac cctgcacagc ttcctccctt agactcccct gcctgcccac ctaagcgaga     1440

cctttgctag ctccactctc acccgctggt cacagaggtc atagatctgg gcttcctggg     1500

tgaaatgtat tcacgggagt ctttagagcg cccaccgctg tgtgtctccc tgcaggtcac     1560

tggatacctg tccttgcgtt ctccagaaag actcagctcc cttattccac tcccaaaagc     1620

tactctgttg gttgccatgg taacccggta agagaggagc tttgtgggag gccgccatgt     1680

ctgcttctct gattccagtg gcaggtagcc tggctttccc aggtccctgg cttggaggga     1740

tggtccttcc tttgggcccg tgtgaaccaa cgagtttccg tacagtgaca gaatgacctc     1800

gcgctgcggc ctggcccagc acaggcatcc aataaacata ttataataaa cgatagctga     1860

gtccttcatg tgcctaggct gccatctcca gccctcccgg agggcgctta gaccattgtc     1920

cacaccgctc ttagacatct aatacatgct tgggcaactg caaggggcac tggagggttt     1980

aagcgacacg tggtaggtag catatgccca tcacccaagc agtacaggag ttcaaggtca     2040

tccttggctc gttaactgcc tgggctacat gagaccctgt ctccgagaaa actaaagctg     2100

ggtctggctg gctggctcag ccggtgaagg tgcttgctgc tacgcctcat ggcctaagct     2160

ccaggggggc cctcatggtg gaaggagaag gctgactctc caaaactgtt ctctggcatc     2220

catactcaca ggtaaatatg aacacaacta cacaagctag agaactttat tgaatctacc     2280

ctttccaagg tgggtcaaag gaggaaggtc cctttggtgt tggccaattt ctttttaaag     2340

atttatttat gtttatgagt atgctgtcac tgtcttcaga cacagcagaa gagggcatcg     2400

gatcccatta cagacttgag ccaccccgtg ggtactggga attgaactca ggaactctgg     2460

aagagcagtc agtgctctta acagctgagc catcccttca gcagccctgt cagatttttt     2520

tttttaatca ccaaagagat tttattcaag tttctaacac aaatgagtta ttttggtttt     2580

gaattacaga actaagtcca aact                                            2604


<210> 42
<211> 417
<212> PRT
<213> Mus musculus

<400> 42
Met Ser Pro Ser Phe Leu Val Leu Leu Thr Ile Leu Gly Pro Gly Asn 
1               5                   10                  15      


Ser Leu Gln Leu Gln Asp Pro Trp Gly His Glu Thr Lys Glu Ala Pro 
            20                  25                  30          


Gly Pro Val His Leu Arg Glu Arg Arg Gln Val Val Gly Asp Asp Asp 
        35                  40                  45              


Phe Glu Asp Pro Asp Tyr Thr Tyr Asn Thr Asp Pro Pro Glu Leu Leu 
    50                  55                  60                  


Lys Asn Val Thr Asn Thr Val Ala Ala His Pro Glu Leu Pro Thr Thr 
65                  70                  75                  80  


Val Val Met Leu Glu Arg Asp Ser Thr Ser Ala Gly Thr Ser Glu Arg 
                85                  90                  95      


Ala Thr Glu Lys Ile Ala Thr Thr Asp Pro Thr Ala Pro Gly Thr Gly 
            100                 105                 110         


Gly Thr Ala Val Gly Met Leu Ser Thr Asp Ser Ala Thr Gln Trp Ser 
        115                 120                 125             


Leu Thr Ser Val Glu Thr Val Gln Pro Ala Ser Thr Glu Val Glu Thr 
    130                 135                 140                 


Ser Gln Pro Ala Pro Met Glu Ala Glu Thr Ser Gln Pro Ala Pro Met 
145                 150                 155                 160 


Glu Ala Glu Thr Ser Gln Pro Ala Pro Met Glu Ala Glu Thr Ser Gln 
                165                 170                 175     


Pro Ala Pro Met Glu Ala Asp Thr Ser Gln Pro Ala Pro Met Glu Ala 
            180                 185                 190         


Asp Thr Ser Lys Pro Ala Pro Thr Glu Ala Glu Thr Ser Lys Pro Ala 
        195                 200                 205             


Pro Thr Glu Ala Glu Thr Ser Gln Pro Ala Pro Asn Glu Ala Glu Thr 
    210                 215                 220                 


Ser Lys Pro Ala Pro Thr Glu Ala Glu Thr Ser Lys Pro Ala Pro Thr 
225                 230                 235                 240 


Glu Ala Glu Thr Thr Gln Leu Pro Arg Ile Gln Ala Val Lys Thr Leu 
                245                 250                 255     


Phe Thr Thr Ser Ala Ala Thr Glu Val Pro Ser Thr Glu Pro Thr Thr 
            260                 265                 270         


Met Glu Thr Ala Ser Thr Glu Ser Asn Glu Ser Thr Ile Phe Leu Gly 
        275                 280                 285             


Pro Ser Val Thr His Leu Pro Asp Ser Gly Leu Lys Lys Gly Leu Ile 
    290                 295                 300                 


Val Thr Pro Gly Asn Ser Pro Ala Pro Thr Leu Pro Gly Ser Ser Asp 
305                 310                 315                 320 


Leu Ile Pro Val Lys Gln Cys Leu Leu Ile Ile Leu Ile Leu Ala Ser 
                325                 330                 335     


Leu Ala Thr Ile Phe Leu Val Cys Thr Val Val Leu Ala Val Arg Leu 
            340                 345                 350         


Ser Arg Lys Thr His Met Tyr Pro Val Arg Asn Tyr Ser Pro Thr Glu 
        355                 360                 365             


Met Ile Cys Ile Ser Ser Leu Leu Pro Glu Gly Gly Asp Gly Ala Pro 
    370                 375                 380                 


Val Thr Ala Asn Gly Gly Leu Pro Lys Val Gln Asp Leu Lys Thr Glu 
385                 390                 395                 400 


Pro Ser Gly Asp Arg Asp Gly Asp Asp Leu Thr Leu His Ser Phe Leu 
                405                 410                 415     


Pro 
    


<210> 43
<211> 519
<212> DNA
<213> Homo sapiens

<400> 43
cgttgtctcc tccacctagc agttggttgg caaccccttc ctcagtcccc tgctgaaaac       60

cctccagtca gcgcttatcc cttctgctct ctcccctcac ccagagaaat acatggagtt      120

tgaccttaat ggaaatggcg atattgatat catgtccctg aaacgaatgc tggagaaact      180

tggagtcccc aagactcacc tagagctaaa gaaattaatt ggagaggtgt ccagtggctc      240

cggggagacg ttcagctacc ctgactttct caggatgatg ctgggcaaga gatctgccat      300

cctaaaaatg atcctgatgt atgaggaaaa agcgagagaa aaggaaaagc caacaggccc      360

cccagccaag aaagctatct ctgagttgcc ctgatttgaa gggaaaaggg atgatgggat      420

tgaaggggct tctaatgacc cagatatgga aacagaagac aaaattgtaa gccagagtca      480

acaaattaaa taaattaccc cctcctccag atcaagtca                             519


<210> 44
<211> 629
<212> DNA
<213> Homo sapiens

<400> 44
aggggaaagg ggaagtttgg gaggaaggct tctgagaaga ctggtgggag agaaggagag       60

cctgcagaca gaggcctcca gcttggagga aaagctttcg gactgctgaa ggcccagcag      120

gaagagaggc tggatgagat caacaagcaa ttcctagacg atcccaaata tagcagtgat      180

gaggatctgc cctccaaact ggaaggcttc aaagagaaat acatggagtt tgaccttaat      240

ggaaatggcg atattgatat catgtccctg aaacgaatgc tggagaaact tggagtcccc      300

aagactcacc tagagctaaa gaaattaatt ggagaggtgt ccagtggctc cggggagacg      360

ttcagctacc ctgactttct caggatgatg ctgggcaaga gatctgccat cctaaaaatg      420

atcctgatgt atgaggaaaa agcgagagaa aaggaaaagc caacaggccc cccagccaag      480

aaagctatct ctgagttgcc ctgatttgaa gggaaaaggg atgatgggat tgaaggggct      540

tctaatgacc cagatatgga aacagaagac aaaattgtaa gccagagtca acaaattaaa      600

taaattaccc cctcctccag atcaagtca                                        629


<210> 45
<211> 93
<212> PRT
<213> Homo sapiens

<400> 45
Met Glu Phe Asp Leu Asn Gly Asn Gly Asp Ile Asp Ile Met Ser Leu 
1               5                   10                  15      


Lys Arg Met Leu Glu Lys Leu Gly Val Pro Lys Thr His Leu Glu Leu 
            20                  25                  30          


Lys Lys Leu Ile Gly Glu Val Ser Ser Gly Ser Gly Glu Thr Phe Ser 
        35                  40                  45              


Tyr Pro Asp Phe Leu Arg Met Met Leu Gly Lys Arg Ser Ala Ile Leu 
    50                  55                  60                  


Lys Met Ile Leu Met Tyr Glu Glu Lys Ala Arg Glu Lys Glu Lys Pro 
65                  70                  75                  80  


Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser Glu Leu Pro 
                85                  90              


<210> 46
<211> 690
<212> DNA
<213> Homo sapiens

<400> 46
aggggaaagg ggaagtttgg gaggaaggct tctgagaaga ctggtgggag agaaggagag       60

cctgcagaca gaggcctcca gcttggtctg tctccccacc tctaccagca tctgctgagc      120

tatgagccaa accagggatt tacagggagg aaaagctttc ggactgctga aggcccagca      180

ggaagagagg ctggatgaga tcaacaagca attcctagac gatcccaaat atagcagtga      240

tgaggatctg ccctccaaac tggaaggctt caaagagaaa tacatggagt ttgaccttaa      300

tggaaatggc gatattgata tcatgtccct gaaacgaatg ctggagaaac ttggagtccc      360

caagactcac ctagagctaa agaaattaat tggagaggtg tccagtggct ccggggagac      420

gttcagctac cctgactttc tcaggatgat gctgggcaag agatctgcca tcctaaaaat      480

gatcctgatg tatgaggaaa aagcgagaga aaaggaaaag ccaacaggcc ccccagccaa      540

gaaagctatc tctgagttgc cctgatttga agggaaaagg gatgatggga ttgaaggggc      600

ttctaatgac ccagatatgg aaacagaaga caaaattgta agccagagtc aacaaattaa      660

ataaattacc ccctcctcca gatcaagtca                                       690


<210> 47
<211> 147
<212> PRT
<213> Homo sapiens

<400> 47
Met Ser Gln Thr Arg Asp Leu Gln Gly Gly Lys Ala Phe Gly Leu Leu 
1               5                   10                  15      


Lys Ala Gln Gln Glu Glu Arg Leu Asp Glu Ile Asn Lys Gln Phe Leu 
            20                  25                  30          


Asp Asp Pro Lys Tyr Ser Ser Asp Glu Asp Leu Pro Ser Lys Leu Glu 
        35                  40                  45              


Gly Phe Lys Glu Lys Tyr Met Glu Phe Asp Leu Asn Gly Asn Gly Asp 
    50                  55                  60                  


Ile Asp Ile Met Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro 
65                  70                  75                  80  


Lys Thr His Leu Glu Leu Lys Lys Leu Ile Gly Glu Val Ser Ser Gly 
                85                  90                  95      


Ser Gly Glu Thr Phe Ser Tyr Pro Asp Phe Leu Arg Met Met Leu Gly 
            100                 105                 110         


Lys Arg Ser Ala Ile Leu Lys Met Ile Leu Met Tyr Glu Glu Lys Ala 
        115                 120                 125             


Arg Glu Lys Glu Lys Pro Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser 
    130                 135                 140                 


Glu Leu Pro 
145         


<210> 48
<211> 935
<212> DNA
<213> Mus musculus

<400> 48
atcctattgt ttccctgtca ggctcctcca aggcccaaac taactggagc cagacgaacc       60

ctctgatgtg gtctgcacag ggcgctaggc tcagctcacc ccattcctgg agcagcctgc      120

agacttcatc ctctctcttc catcccgggg aaagtcagcc agtcctcctc agctgcctgt      180

cttaacctgc atcatgaagc ctgaggagat ttcaacagaa gctgatgtgg aagtgatgcc      240

tgggagttag caagggaatg agtggaaagg ggaagtgtga gaacggtccc agaagagact      300

ggggagctgg tggagagagg acccagcgga cagactgcca gcctaagaca accagcgtct      360

gaggagccat gagccaaagc agggatttgc agggaggaaa agcttttgga ctgctgaagg      420

cccagcagga agagaggctg gaggggatca acaagcaatt cctcgatgat cccaaataca      480

gcaatgatga ggatctgccg tccaaacttg aagccttcaa ggtgaagtac atggagtttg      540

atctgaatgg aaatggagat atcgatatta tgtccttgaa gcgaatgctg gagaaacttg      600

gggttcccaa gacccaccta gagctgaaga gattaattag agaggtgtcc agtggctccg      660

aggagacgtt cagctactct gactttctca gaatgatgct gggcaagaga tctgccatct      720

tgagaatgat tctgatgtat gaggagaaaa acaaagaaca caagaggcca actggtcccc      780

cagccaagaa agctatctcc gagctgccct gattggaggt ggatgtcaca cggtggggct      840

gagtgaggag cttctgatga cagcagcatg gaaaaaagaa acagtcgtga gccagagtca      900

gactaaataa atgacgctcc tagtgggtca catca                                 935


<210> 49
<211> 948
<212> DNA
<213> Mus musculus

<400> 49
atcctattgt ttccctgtca ggctcctcca aggcccaaac taactggagc cagacgaacc       60

ctctgatgtg gtctgcacag ggcgctaggc tcagctcacc ccattcctgg agcagcctgc      120

agacttcatc ctctctcttc catcccgggg aaagtcagcc agtcctcctc agctgcctgt      180

cttaacctgc atcatgaagc ctgaggagat ttcaaaagct gatgtggaag tgatgcctgg      240

gagttagcaa gggaatgagt ggaaagggga agtgtgagaa cggtcccaga agagactggg      300

gagctggtgg agagaggacc cagcggacag actgccagcc taagacaacc agcgtctgag      360

gagccatgag ccaaagcagg gatttgcagg gaggaaaagc ttttggactg ctgaaggccc      420

agcaggaaga gaggctggag gggatcaaca agcaattcct cgatgatccc aaatacagca      480

atgatgagga tctgccgtcc aaacttgaag ccttcaaggt gaagtacatg gagtttgatc      540

tgaatggaaa tggagatatc gatattatgt ccttgaagcg aatgctggag aaacttgggg      600

ttcccaagac ccacctagag ctgaagagat taattagaga ggtgtccagt ggctccgagg      660

agacgttcag ctactctgac tttctcagaa tgatgctggg caagagatct gccatcttga      720

gaatgattct gatgtatgag gagaaaaaca aagaacacaa gaggccaact ggtcccccag      780

ccaagaaagc tatctccgag ctgccctgat tggaggtgga tgtcacacgg tggggctgag      840

tgaggagctt ctgatgacag cagcatggaa aaaagaaaca gtcgtgagcc agagtcagac      900

taaataaatg acgctcctag tgggtcacat caaaaaaaaa aaaaaaaa                   948


<210> 50
<211> 147
<212> PRT
<213> Mus musculus

<400> 50
Met Ser Gln Ser Arg Asp Leu Gln Gly Gly Lys Ala Phe Gly Leu Leu 
1               5                   10                  15      


Lys Ala Gln Gln Glu Glu Arg Leu Glu Gly Ile Asn Lys Gln Phe Leu 
            20                  25                  30          


Asp Asp Pro Lys Tyr Ser Asn Asp Glu Asp Leu Pro Ser Lys Leu Glu 
        35                  40                  45              


Ala Phe Lys Val Lys Tyr Met Glu Phe Asp Leu Asn Gly Asn Gly Asp 
    50                  55                  60                  


Ile Asp Ile Met Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro 
65                  70                  75                  80  


Lys Thr His Leu Glu Leu Lys Arg Leu Ile Arg Glu Val Ser Ser Gly 
                85                  90                  95      


Ser Glu Glu Thr Phe Ser Tyr Ser Asp Phe Leu Arg Met Met Leu Gly 
            100                 105                 110         


Lys Arg Ser Ala Ile Leu Arg Met Ile Leu Met Tyr Glu Glu Lys Asn 
        115                 120                 125             


Lys Glu His Lys Arg Pro Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser 
    130                 135                 140                 


Glu Leu Pro 
145         


<210> 51
<211> 757
<212> DNA
<213> Mus musculus

<400> 51
atcctattgt ttccctgtca ggctcctcca aggcccaaac taactggagc cagacgaacc       60

ctctgatgtg gtctgcacag ggcgctaggc tcagctcacc ccattcctgg agcagcctgc      120

agacttcatc ctctctcttc catcccgggg aaagtcagcc agtcctcctc agctgcctgt      180

cttaacctgc atcatgaagc ctgaggagat ttcaagagga aaagcttttg gactgctgaa      240

ggcccagcag gaagagaggc tggaggggat caacaagcaa ttcctcgatg atcccaaata      300

cagcaatgat gaggatctgc cgtccaaact tgaagccttc aaggtgaagt acatggagtt      360

tgatctgaat ggaaatggag atatcgatat tatgtccttg aagcgaatgc tggagaaact      420

tggggttccc aagacccacc tagagctgaa gagattaatt agagaggtgt ccagtggctc      480

cgaggagacg ttcagctact ctgactttct cagaatgatg ctgggcaaga gatctgccat      540

cttgagaatg attctgatgt atgaggagaa aaacaaagaa cacaagaggc caactggtcc      600

cccagccaag aaagctatct ccgagctgcc ctgattggag gtggatgtca cacggtgggg      660

ctgagtgagg agcttctgat gacagcagca tggaaaaaag aaacagtcgt gagccagagt      720

cagactaaat aaatgacgct cctagtgggt cacatca                               757


<210> 52
<211> 146
<212> PRT
<213> Mus musculus

<400> 52
Met Lys Pro Glu Glu Ile Ser Arg Gly Lys Ala Phe Gly Leu Leu Lys 
1               5                   10                  15      


Ala Gln Gln Glu Glu Arg Leu Glu Gly Ile Asn Lys Gln Phe Leu Asp 
            20                  25                  30          


Asp Pro Lys Tyr Ser Asn Asp Glu Asp Leu Pro Ser Lys Leu Glu Ala 
        35                  40                  45              


Phe Lys Val Lys Tyr Met Glu Phe Asp Leu Asn Gly Asn Gly Asp Ile 
    50                  55                  60                  


Asp Ile Met Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro Lys 
65                  70                  75                  80  


Thr His Leu Glu Leu Lys Arg Leu Ile Arg Glu Val Ser Ser Gly Ser 
                85                  90                  95      


Glu Glu Thr Phe Ser Tyr Ser Asp Phe Leu Arg Met Met Leu Gly Lys 
            100                 105                 110         


Arg Ser Ala Ile Leu Arg Met Ile Leu Met Tyr Glu Glu Lys Asn Lys 
        115                 120                 125             


Glu His Lys Arg Pro Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser Glu 
    130                 135                 140                 


Leu Pro 
145     


<210> 53
<211> 8296
<212> DNA
<213> Homo sapiens

<400> 53
ggaggaagaa aactcaagtg aaactgactc tgctagaaca gtgccgtgct tttccacaga       60

aggttagacc ctgaaagaga tggctcagca ccacctatgg atcttgctcc tttgcctgca      120

aacctggccg gaagcagctg gaaaagactc agaaatcttc acagtgaatg ggattctggg      180

agagtcagtc actttccctg taaatatcca agaaccacgg caagttaaaa tcattgcttg      240

gacttctaaa acatctgttg cttatgtaac accaggagac tcagaaacag cacccgtagt      300

tactgtgacc cacagaaatt attatgaacg gatacatgcc ttaggtccga actacaatct      360

ggtcattagc gatctgagga tggaagacgc aggagactac aaagcagaca taaatacaca      420

ggctgatccc tacaccacca ccaagcgcta caacctgcaa atctatcgtc ggcttgggaa      480

accaaaaatt acacagagtt taatggcatc tgtgaacagc acctgtaatg tcacactgac      540

atgctctgta gagaaagaag aaaagaatgt gacatacaat tggagtcccc tgggagaaga      600

gggtaatgtc cttcaaatct tccagactcc tgaggaccaa gagctgactt acacgtgtac      660

agcccagaac cctgtcagca acaattctga ctccatctct gcccggcagc tctgtgcaga      720

catcgcaatg ggcttccgta ctcaccacac cgggttgctg agcgtgctgg ctatgttctt      780

tctgcttgtt ctcattctgt cttcagtgtt tttgttccgt ttgttcaaga gaagacaagg      840

taggattttc ccagaaggtt cctgcttgaa caccttcact aagaaccctt atgctgcctc      900

aaagaaaacc atatacacat atatcatggc ttcaaggaac acccagccag cagagtccag      960

aatctatgat gaaatcctgc agtccaaggt gcttccctcc aaggaagagc cagtgaacac     1020

agtttattcc gaagtgcagt ttgctgataa gatggggaaa gccagcacac aggacagtaa     1080

acctcctggg acttcaagct atgaaattgt gatctaggct gctgggctga attctccctc     1140

tggaaactga gttacaacca ccaatactgg caggttccct ggatccagat cttctctgcc     1200

caactcttac tgggagattg caaactgcca catctcagcc tgtaagcaaa gcaggaaacc     1260

ttctgctggg catagcttgt gcctaaatgg acaaatggat gcataccctt cctgaaatga     1320

ctcccttctg aatgaatgac aaagcaggtt acctagtata gttttcccaa acttcttccc     1380

atcatagcac atgtagaaaa taatattttt atggcacact gggataaaca agcaagattg     1440

ctcacttctg gaagctgcat atgactagag gcctcttgtg actggaggta acaaccctgc     1500

ccagtaactg tgggagaagg ggatcaatat tttgcacacc tgtaataggc catggcacac     1560

cagccaagat gctctgctca cagtcagtat gtgtgaagat ccctggtgcg tggccttcac     1620

cacgcatctt gagcaaatta ggaaaatgta cccttcgctt gaggcagatg cagcccttcc     1680

cccgagtgca tggcttggag agcagaatgt gggctgcata taagcacact catccctttg     1740

tctgggaatc tttgtgcagg gcataacagg cttagtaagt ccaaacacag atgacagtgc     1800

tgtgtgggtc tctgtcagag ttgtggctct cagccatgta gacacactct ccaaatggag     1860

tgttggaaaa tgttctttct gcagggtcta gagactgctg ggacactttt cttggagtgc     1920

tacttcagaa gccttatagg attttctttc tggccaagat ttccttctgt atcactccaa     1980

gcagcctcag cagaagaagc agccatgccc agtattccca ctctccaaaa ggaactgacc     2040

agcttatatt tctcacactt ctggggaact gggtataatc caaccatcaa aatagaagac     2100

cttgcaagaa gcagagtcat tctccagaag gaacttggga gatgatggtg cagatgatga     2160

aactgggttc atcccagttc caaagactca gagaactaga gtttaagctg aggcagagtg     2220

ccgccaccct ggcatgcccc acaaacagat caccagccag cttacacagg cattaactct     2280

cctcaatgag gaagaatcat tcacaactga gcaagacatt catatgatca tttaaggaag     2340

tgtttccctt atgtgttagc aagtataatc ggctaactcc taaatcccaa tgaatagtcc     2400

taggctggac agcaatgggc tgcaattagg cagataaaga catcagtccc agtaaatgaa     2460

tccatagact catctagcac caactaccat tagcactatg ttaggagctg caaggcccca     2520

aagtagaaga tgtgcataat gtctgctctt gtgtagctca ggagacaatt ccagcacaga     2580

cactacagtt aacgctgaac tgcagctgca agtaatagca tgaacagtca gaaaaatacc     2640

ttatgagggg gcagggctga agctgggcct tgaaggatgg atgaaatttg gatagagaat     2700

gaggaagaca gagggcctcc aagtgagaga agcatgaaaa atgagcaggg gcctggatca     2760

gtggggtgta ttcagagcac ctctccagat gcaccatgca tgctcacagt cccttgccta     2820

tgtgtggcag agtgtcccag ccagatgtgt gccctcaccc catgtccatt tacatgtcct     2880

tcaatgccca cctcaaaagg tacctcttct gtaaagcttt ccctggtatc aggaatcaaa     2940

attaatcagg gatcttttca cactgctgtt ttttcctctt tggtccttct atcactaaaa     3000

ctcatctcat tcagccttac agcataacta attatttgtt ttcctcacta cattgtacat     3060

gtgggaatta cagataaacg gaagccggct ggggtggtgg ctcacgcctg taatcccaac     3120

actttgggag gccaaggcag gcggatcacc tgaggtcagg agttcgagat tagtctggcc     3180

aacatggtga aaccccatct ctactaaaaa tacgaaatta gccaggtgtg gtggcacaca     3240

tctgtagtcc cagctactct ggaggctgag acaggagaat cgcttgaacc caggaagtgg     3300

aggttgcagt gagctgagat cacaccactg cactccagcc tgggagagac agagtgagac     3360

tccatctcga aaaaaaaaaa aagatagaag ccaataagca tggtgcaatc aaattctggc     3420

aagcattaaa tatcaggatg cagctgggca cggtggctca cgcctgtaat cccagcactt     3480

tgggaggcca aggtgggcgg atcacttgag gtcaggaatt tgagaggatc ctggccagca     3540

tggcaaaacc ccatctgtac ttaaaataca aaaaaattag ctgggcgtgg tggtgcacac     3600

ctgtaatccc agctacttgg gaggctgagg tgggagaatt gcttgaacct gggaggtgga     3660

ggttgcagtg agctgagatc ctgccactgc actccaggct gggcaacaga gtgagaccat     3720

gtctcaaaaa ataaaaataa aataaaataa tatcaggatg catacatcag aggctgttcc     3780

tagtgtaaag gcactttgga gggagaagac tttcagagtt aggcagacca actaagaggt     3840

cagctgaagc acctaaccag ttgtaaggag gtgaaagaca gcaccccaag aagagacgtg     3900

caggaaggag gaaagaggct tggtcataaa ggatggagga attccaaagt gacactgaac     3960

aggctgcgtt tatcctaaaa taaaaccact cctcactctg tggatgcgtt gaagactcat     4020

tcccaaacat ctttattctc taacttgccc tcttcctctt cctaatatgc tcactcaagt     4080

aaaattacta gtgtcctaat gcccctatgc atattgtcaa aaataaaaat cagaagcagg     4140

ttagatctgt taggtcttcc agaagagcaa acctgggatg aagccagagc ccaggaattc     4200

tgaaggtagc ctttggactc aggacaccct actcttgtct ctcctctcag tttctctgct     4260

atgaatctcc tgattcatga acacgttatc tgttcaccct tctctctagg tcttagttct     4320

tagattttcc ttctgtaaaa tgcatgtgat cttattttcc cctccacaac tttccagatg     4380

aactagactg tgaccaagag gtctataaaa tcaaagcatc atggaacagg atcttgtatc     4440

agaccaaagt gtgccagttt ttaaaaatgt gcatcaaaat ggaagtctca gagacagagc     4500

cctctggtgg aaagttctag taggttagga cagtcctgcc tgcagacacc ttgggcttta     4560

ctgagggact caactgagaa aatgaggaat gttgcagctc atgattctta gaagaagaaa     4620

gtgaagcttg tttaaaatat gatttaaaaa atctgtagaa cactgtaaac tacacaggct     4680

atgagggaat agcctggttg ggccagcttg gaaatcgggc acaggcagga aggggcctgt     4740

ctggtttggg ccgtgtccac agagagcact tcttaggtcc tgcctggaga gaaggaatgg     4800

ctgggctata ttttcttcca gactcattat ttttcttctg tttgactttt ctctgaattt     4860

cccttgattt gtataaattt tctcaataat tagtgacagt gtctactgat tgtaaaatga     4920

agcttgaagg ccaggcgcag tggctcatgc ctgtaatcct agaattttgg gaggccaagg     4980

tgggtggatc acaaggagtt cgagaccagc ctggccaagg ttgtgaaacc gcgtctctac     5040

taaaaataca aaaaaattag ccgggcatgg tggcacgtgc ctgtagtccc agctactcag     5100

gaagctgagg caacagaatc acttgaacct gggaggtgga ggttgcagtg agccgagatc     5160

acgccactgc actccagcct gggcgagaga gtgagactcc gtctcaaaaa aaaaaaaaaa     5220

aaaaaaagtt tgaagaacaa agacaataag aggaaatata atgagtggtc ataaatgtgg     5280

gctctgacag tagagtgcct gggtctgcat cctggtttct tagtcatgtg accttaggca     5340

agttacttta acctcgctgt acctcaggtt gtccatctgt aaaatgggga taataatagt     5400

gcctaccttt taaggttgat gtggggatta aatgaggtgt tgctcataca ggaatgtgcc     5460

tgtgcatggc aaagttcggg aaatttttta taagctgttc taggcctgaa atcttcagaa     5520

gatgctaatc taaattcatg aaataagctt cttacaacag aaatgctgct agtattatgc     5580

aaaattaatg ttgtatatca aacttttaac tctcatccct ccttattcag atatattttg     5640

ttataagcaa tgtttgttcc cctcgttatt ataccacagt ctacttacct gatgctatat     5700

ctgcctcccc agttagactg agagaacagg ggatatacct aaataataat aataataata     5760

ataataataa ataataatgg agagctcctt gaagataggg agcctgtaag aatcattgag     5820

ggcttatttt gtataccaac tgctaaacta gatgcttcat acattgttgt caatactcat     5880

gacagccttg taaagtagaa attaattctt ccagttaaca ctaaggctga catatgaata     5940

ccttggcaaa tctggaaagc tgggaagaca gtatttgaat tcaagacttc ttgtcaccaa     6000

gggccatgca cttgtactct gccatgtggc ccttttttac ctcctgtgga ttctccctac     6060

ctggtacttg gccttaggtg tacacacacc tggcactttg cttgacacat aataggtgga     6120

ccacaaatat ctactaaatg aatatttgca tatagtaata ttttaaggta ctaaaagcag     6180

ctcaaagtaa atatattaat atattaattc cattgctatc tggataacca ctcaactttc     6240

ctgctgaaaa tgcccattta attaaagaag gttggataga gctctctata tgcattttgg     6300

acaggcaggg gtttcaggtc ataaacattc tgatgagtta atataaaata agagaaactg     6360

taaatttcca ctactaaaaa tcacaaaaat aacagaaaca aaagaagaga taagaatttg     6420

gggaattgtg ctgaacaatt tagtggttaa aaaaaacaac tgtgcatgtt tagacttaaa     6480

taagccccca tccaagtgtg aggggtccag taatttttca aaacatatga aagtgttaat     6540

acatttcgac aaaggaccat taaaaaagtc ctgaattctg acttgaggga ggaaagtaat     6600

gactaataca ttctctagag acttgcagac tttgggaatt cataaaggaa tggatgataa     6660

ttattaactg ttgctggctg attgcccaga cagttctcaa cagccctgta caagtctctg     6720

ggtttgggat ggatcaattc tgagactgga aaatggccaa atctttgcaa atgagaaata     6780

tttttcttat aagttcttat tgtaggcaaa taattacata gattattcat cagagaattt     6840

ttaaatgctc ataatctcaa ctctttcatt tacaacttgt atttccaata gtttatgggt     6900

catctctgca tagatgtcag aagtcacctc aagtttagcg tgtccaaaat ctaactcaca     6960

ggtctgtttc tgacctccca acttgctttc cttgtgtttt tcctatgcta atgatccacc     7020

ataatcaaaa taattaacat ttatccagtg cctactatgt actattccct gtcctgtttt     7080

acatttactc atttaaagtc cataagaaac attaaatctc atctgccttc tgaagaagat     7140

acaaccatgc tctcttttac aaagtaggaa actgggtcac agaaaggtga agtctttaag     7200

gctgaatcac agtagctcat cctagtaaat agaaaagcca ggattcaact ccaggggctg     7260

ggtgcagaac tgctattctt cactgcttca ccaatcagca gctacccaag gcagaaaact     7320

ttttcatcct tggctccttc attctccctg tcaccccaga tcccctctac atctagtcag     7380

agaataggtc ctgtcaattc caacttctct atatggctcc tctcaggcat gtgcccttaa     7440

ttggcctaat tctctaatac accttccctc tacatgctca ctccctcaga tcattgcttt     7500

atcacgtgtt acctgggttg ctattacata aagagcaatc tttctaaaat gaggatctta     7560

tcacttcact tccacactaa aatgtttttc ctggggaacc acactcctta gcaatctgac     7620

ccatcagacc ttccaggctg tctcctgcct gctccctaag gctccagcca cacagaatta     7680

tcatgggccc acacacccac caaatcctcc catgcctttg cccatgttgt ctgggatgcc     7740

cttctctccc ttctgtctac atcaagcatc agactgaata tccctcttgt gcggccttct     7800

aaaacctccc gtccaaagcg aaatatattg ccctctattt atacttttac agcatttggc     7860

acacaagtac agagtagtag ctttttatca cattctctga taattatata gatatggtat     7920

ttcttagctc tctctccaac tggctaataa gttgcttttt gtctgagtgc ctaattttgt     7980

gttttgtgtc tgagtgcctc agttcctcaa aaaaaggttt tttgattagt tcattattca     8040

tttgaacatg gaaattatgc tcactagtgg caaatgccac taaccgtatt ccagaagcta     8100

ggtgtcatgt ttgcaataag atatattatc ccttctacaa gtcacctttt atttcaggca     8160

tttgtaaatg cccattaata aagtatggtt cataaatttt accttgtaag tgcctaagaa     8220

atgagactac aagctccatt tcagcaggac acaataaata ttattttata atgcatctaa     8280

aaaaaaaaaa aaaaaa                                                     8296


<210> 54
<211> 345
<212> PRT
<213> Homo sapiens

<400> 54
Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Gly Arg Ile 
                245                 250                 255     


Phe Pro Glu Gly Ser Cys Leu Asn Thr Phe Thr Lys Asn Pro Tyr Ala 
            260                 265                 270         


Ala Ser Lys Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr 
        275                 280                 285             


Gln Pro Ala Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val 
    290                 295                 300                 


Leu Pro Ser Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln 
305                 310                 315                 320 


Phe Ala Asp Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro 
                325                 330                 335     


Gly Thr Ser Ser Tyr Glu Ile Val Ile 
            340                 345 


<210> 55
<211> 8245
<212> DNA
<213> Homo sapiens

<400> 55
ggaggaagaa aactcaagtg aaactgactc tgctagaaca gtgccgtgct tttccacaga       60

aggttagacc ctgaaagaga tggctcagca ccacctatgg atcttgctcc tttgcctgca      120

aacctggccg gaagcagctg gaaaagactc agaaatcttc acagtgaatg ggattctggg      180

agagtcagtc actttccctg taaatatcca agaaccacgg caagttaaaa tcattgcttg      240

gacttctaaa acatctgttg cttatgtaac accaggagac tcagaaacag cacccgtagt      300

tactgtgacc cacagaaatt attatgaacg gatacatgcc ttaggtccga actacaatct      360

ggtcattagc gatctgagga tggaagacgc aggagactac aaagcagaca taaatacaca      420

ggctgatccc tacaccacca ccaagcgcta caacctgcaa atctatcgtc ggcttgggaa      480

accaaaaatt acacagagtt taatggcatc tgtgaacagc acctgtaatg tcacactgac      540

atgctctgta gagaaagaag aaaagaatgt gacatacaat tggagtcccc tgggagaaga      600

gggtaatgtc cttcaaatct tccagactcc tgaggaccaa gagctgactt acacgtgtac      660

agcccagaac cctgtcagca acaattctga ctccatctct gcccggcagc tctgtgcaga      720

catcgcaatg ggcttccgta ctcaccacac cgggttgctg agcgtgctgg ctatgttctt      780

tctgcttgtt ctcattctgt cttcagtgtt tttgttccgt ttgttcaaga gaagacaaga      840

tgctgcctca aagaaaacca tatacacata tatcatggct tcaaggaaca cccagccagc      900

agagtccaga atctatgatg aaatcctgca gtccaaggtg cttccctcca aggaagagcc      960

agtgaacaca gtttattccg aagtgcagtt tgctgataag atggggaaag ccagcacaca     1020

ggacagtaaa cctcctggga cttcaagcta tgaaattgtg atctaggctg ctgggctgaa     1080

ttctccctct ggaaactgag ttacaaccac caatactggc aggttccctg gatccagatc     1140

ttctctgccc aactcttact gggagattgc aaactgccac atctcagcct gtaagcaaag     1200

caggaaacct tctgctgggc atagcttgtg cctaaatgga caaatggatg catacccttc     1260

ctgaaatgac tcccttctga atgaatgaca aagcaggtta cctagtatag ttttcccaaa     1320

cttcttccca tcatagcaca tgtagaaaat aatattttta tggcacactg ggataaacaa     1380

gcaagattgc tcacttctgg aagctgcata tgactagagg cctcttgtga ctggaggtaa     1440

caaccctgcc cagtaactgt gggagaaggg gatcaatatt ttgcacacct gtaataggcc     1500

atggcacacc agccaagatg ctctgctcac agtcagtatg tgtgaagatc cctggtgcgt     1560

ggccttcacc acgcatcttg agcaaattag gaaaatgtac ccttcgcttg aggcagatgc     1620

agcccttccc ccgagtgcat ggcttggaga gcagaatgtg ggctgcatat aagcacactc     1680

atccctttgt ctgggaatct ttgtgcaggg cataacaggc ttagtaagtc caaacacaga     1740

tgacagtgct gtgtgggtct ctgtcagagt tgtggctctc agccatgtag acacactctc     1800

caaatggagt gttggaaaat gttctttctg cagggtctag agactgctgg gacacttttc     1860

ttggagtgct acttcagaag ccttatagga ttttctttct ggccaagatt tccttctgta     1920

tcactccaag cagcctcagc agaagaagca gccatgccca gtattcccac tctccaaaag     1980

gaactgacca gcttatattt ctcacacttc tggggaactg ggtataatcc aaccatcaaa     2040

atagaagacc ttgcaagaag cagagtcatt ctccagaagg aacttgggag atgatggtgc     2100

agatgatgaa actgggttca tcccagttcc aaagactcag agaactagag tttaagctga     2160

ggcagagtgc cgccaccctg gcatgcccca caaacagatc accagccagc ttacacaggc     2220

attaactctc ctcaatgagg aagaatcatt cacaactgag caagacattc atatgatcat     2280

ttaaggaagt gtttccctta tgtgttagca agtataatcg gctaactcct aaatcccaat     2340

gaatagtcct aggctggaca gcaatgggct gcaattaggc agataaagac atcagtccca     2400

gtaaatgaat ccatagactc atctagcacc aactaccatt agcactatgt taggagctgc     2460

aaggccccaa agtagaagat gtgcataatg tctgctcttg tgtagctcag gagacaattc     2520

cagcacagac actacagtta acgctgaact gcagctgcaa gtaatagcat gaacagtcag     2580

aaaaatacct tatgaggggg cagggctgaa gctgggcctt gaaggatgga tgaaatttgg     2640

atagagaatg aggaagacag agggcctcca agtgagagaa gcatgaaaaa tgagcagggg     2700

cctggatcag tggggtgtat tcagagcacc tctccagatg caccatgcat gctcacagtc     2760

ccttgcctat gtgtggcaga gtgtcccagc cagatgtgtg ccctcacccc atgtccattt     2820

acatgtcctt caatgcccac ctcaaaaggt acctcttctg taaagctttc cctggtatca     2880

ggaatcaaaa ttaatcaggg atcttttcac actgctgttt tttcctcttt ggtccttcta     2940

tcactaaaac tcatctcatt cagccttaca gcataactaa ttatttgttt tcctcactac     3000

attgtacatg tgggaattac agataaacgg aagccggctg gggtggtggc tcacgcctgt     3060

aatcccaaca ctttgggagg ccaaggcagg cggatcacct gaggtcagga gttcgagatt     3120

agtctggcca acatggtgaa accccatctc tactaaaaat acgaaattag ccaggtgtgg     3180

tggcacacat ctgtagtccc agctactctg gaggctgaga caggagaatc gcttgaaccc     3240

aggaagtgga ggttgcagtg agctgagatc acaccactgc actccagcct gggagagaca     3300

gagtgagact ccatctcgaa aaaaaaaaaa agatagaagc caataagcat ggtgcaatca     3360

aattctggca agcattaaat atcaggatgc agctgggcac ggtggctcac gcctgtaatc     3420

ccagcacttt gggaggccaa ggtgggcgga tcacttgagg tcaggaattt gagaggatcc     3480

tggccagcat ggcaaaaccc catctgtact taaaatacaa aaaaattagc tgggcgtggt     3540

ggtgcacacc tgtaatccca gctacttggg aggctgaggt gggagaattg cttgaacctg     3600

ggaggtggag gttgcagtga gctgagatcc tgccactgca ctccaggctg ggcaacagag     3660

tgagaccatg tctcaaaaaa taaaaataaa ataaaataat atcaggatgc atacatcaga     3720

ggctgttcct agtgtaaagg cactttggag ggagaagact ttcagagtta ggcagaccaa     3780

ctaagaggtc agctgaagca cctaaccagt tgtaaggagg tgaaagacag caccccaaga     3840

agagacgtgc aggaaggagg aaagaggctt ggtcataaag gatggaggaa ttccaaagtg     3900

acactgaaca ggctgcgttt atcctaaaat aaaaccactc ctcactctgt ggatgcgttg     3960

aagactcatt cccaaacatc tttattctct aacttgccct cttcctcttc ctaatatgct     4020

cactcaagta aaattactag tgtcctaatg cccctatgca tattgtcaaa aataaaaatc     4080

agaagcaggt tagatctgtt aggtcttcca gaagagcaaa cctgggatga agccagagcc     4140

caggaattct gaaggtagcc tttggactca ggacacccta ctcttgtctc tcctctcagt     4200

ttctctgcta tgaatctcct gattcatgaa cacgttatct gttcaccctt ctctctaggt     4260

cttagttctt agattttcct tctgtaaaat gcatgtgatc ttattttccc ctccacaact     4320

ttccagatga actagactgt gaccaagagg tctataaaat caaagcatca tggaacagga     4380

tcttgtatca gaccaaagtg tgccagtttt taaaaatgtg catcaaaatg gaagtctcag     4440

agacagagcc ctctggtgga aagttctagt aggttaggac agtcctgcct gcagacacct     4500

tgggctttac tgagggactc aactgagaaa atgaggaatg ttgcagctca tgattcttag     4560

aagaagaaag tgaagcttgt ttaaaatatg atttaaaaaa tctgtagaac actgtaaact     4620

acacaggcta tgagggaata gcctggttgg gccagcttgg aaatcgggca caggcaggaa     4680

ggggcctgtc tggtttgggc cgtgtccaca gagagcactt cttaggtcct gcctggagag     4740

aaggaatggc tgggctatat tttcttccag actcattatt tttcttctgt ttgacttttc     4800

tctgaatttc ccttgatttg tataaatttt ctcaataatt agtgacagtg tctactgatt     4860

gtaaaatgaa gcttgaaggc caggcgcagt ggctcatgcc tgtaatccta gaattttggg     4920

aggccaaggt gggtggatca caaggagttc gagaccagcc tggccaaggt tgtgaaaccg     4980

cgtctctact aaaaatacaa aaaaattagc cgggcatggt ggcacgtgcc tgtagtccca     5040

gctactcagg aagctgaggc aacagaatca cttgaacctg ggaggtggag gttgcagtga     5100

gccgagatca cgccactgca ctccagcctg ggcgagagag tgagactccg tctcaaaaaa     5160

aaaaaaaaaa aaaaaagttt gaagaacaaa gacaataaga ggaaatataa tgagtggtca     5220

taaatgtggg ctctgacagt agagtgcctg ggtctgcatc ctggtttctt agtcatgtga     5280

ccttaggcaa gttactttaa cctcgctgta cctcaggttg tccatctgta aaatggggat     5340

aataatagtg cctacctttt aaggttgatg tggggattaa atgaggtgtt gctcatacag     5400

gaatgtgcct gtgcatggca aagttcggga aattttttat aagctgttct aggcctgaaa     5460

tcttcagaag atgctaatct aaattcatga aataagcttc ttacaacaga aatgctgcta     5520

gtattatgca aaattaatgt tgtatatcaa acttttaact ctcatccctc cttattcaga     5580

tatattttgt tataagcaat gtttgttccc ctcgttatta taccacagtc tacttacctg     5640

atgctatatc tgcctcccca gttagactga gagaacaggg gatataccta aataataata     5700

ataataataa taataataaa taataatgga gagctccttg aagataggga gcctgtaaga     5760

atcattgagg gcttattttg tataccaact gctaaactag atgcttcata cattgttgtc     5820

aatactcatg acagccttgt aaagtagaaa ttaattcttc cagttaacac taaggctgac     5880

atatgaatac cttggcaaat ctggaaagct gggaagacag tatttgaatt caagacttct     5940

tgtcaccaag ggccatgcac ttgtactctg ccatgtggcc cttttttacc tcctgtggat     6000

tctccctacc tggtacttgg ccttaggtgt acacacacct ggcactttgc ttgacacata     6060

ataggtggac cacaaatatc tactaaatga atatttgcat atagtaatat tttaaggtac     6120

taaaagcagc tcaaagtaaa tatattaata tattaattcc attgctatct ggataaccac     6180

tcaactttcc tgctgaaaat gcccatttaa ttaaagaagg ttggatagag ctctctatat     6240

gcattttgga caggcagggg tttcaggtca taaacattct gatgagttaa tataaaataa     6300

gagaaactgt aaatttccac tactaaaaat cacaaaaata acagaaacaa aagaagagat     6360

aagaatttgg ggaattgtgc tgaacaattt agtggttaaa aaaaacaact gtgcatgttt     6420

agacttaaat aagcccccat ccaagtgtga ggggtccagt aatttttcaa aacatatgaa     6480

agtgttaata catttcgaca aaggaccatt aaaaaagtcc tgaattctga cttgagggag     6540

gaaagtaatg actaatacat tctctagaga cttgcagact ttgggaattc ataaaggaat     6600

ggatgataat tattaactgt tgctggctga ttgcccagac agttctcaac agccctgtac     6660

aagtctctgg gtttgggatg gatcaattct gagactggaa aatggccaaa tctttgcaaa     6720

tgagaaatat ttttcttata agttcttatt gtaggcaaat aattacatag attattcatc     6780

agagaatttt taaatgctca taatctcaac tctttcattt acaacttgta tttccaatag     6840

tttatgggtc atctctgcat agatgtcaga agtcacctca agtttagcgt gtccaaaatc     6900

taactcacag gtctgtttct gacctcccaa cttgctttcc ttgtgttttt cctatgctaa     6960

tgatccacca taatcaaaat aattaacatt tatccagtgc ctactatgta ctattccctg     7020

tcctgtttta catttactca tttaaagtcc ataagaaaca ttaaatctca tctgccttct     7080

gaagaagata caaccatgct ctcttttaca aagtaggaaa ctgggtcaca gaaaggtgaa     7140

gtctttaagg ctgaatcaca gtagctcatc ctagtaaata gaaaagccag gattcaactc     7200

caggggctgg gtgcagaact gctattcttc actgcttcac caatcagcag ctacccaagg     7260

cagaaaactt tttcatcctt ggctccttca ttctccctgt caccccagat cccctctaca     7320

tctagtcaga gaataggtcc tgtcaattcc aacttctcta tatggctcct ctcaggcatg     7380

tgcccttaat tggcctaatt ctctaataca ccttccctct acatgctcac tccctcagat     7440

cattgcttta tcacgtgtta cctgggttgc tattacataa agagcaatct ttctaaaatg     7500

aggatcttat cacttcactt ccacactaaa atgtttttcc tggggaacca cactccttag     7560

caatctgacc catcagacct tccaggctgt ctcctgcctg ctccctaagg ctccagccac     7620

acagaattat catgggccca cacacccacc aaatcctccc atgcctttgc ccatgttgtc     7680

tgggatgccc ttctctccct tctgtctaca tcaagcatca gactgaatat ccctcttgtg     7740

cggccttcta aaacctcccg tccaaagcga aatatattgc cctctattta tacttttaca     7800

gcatttggca cacaagtaca gagtagtagc tttttatcac attctctgat aattatatag     7860

atatggtatt tcttagctct ctctccaact ggctaataag ttgctttttg tctgagtgcc     7920

taattttgtg ttttgtgtct gagtgcctca gttcctcaaa aaaaggtttt ttgattagtt     7980

cattattcat ttgaacatgg aaattatgct cactagtggc aaatgccact aaccgtattc     8040

cagaagctag gtgtcatgtt tgcaataaga tatattatcc cttctacaag tcacctttta     8100

tttcaggcat ttgtaaatgc ccattaataa agtatggttc ataaatttta ccttgtaagt     8160

gcctaagaaa tgagactaca agctccattt cagcaggaca caataaatat tattttataa     8220

tgcatctaaa aaaaaaaaaa aaaaa                                           8245


<210> 56
<211> 328
<212> PRT
<213> Homo sapiens

<400> 56
Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Asp Ala Ala 
                245                 250                 255     


Ser Lys Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln 
            260                 265                 270         


Pro Ala Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu 
        275                 280                 285             


Pro Ser Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe 
    290                 295                 300                 


Ala Asp Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly 
305                 310                 315                 320 


Thr Ser Ser Tyr Glu Ile Val Ile 
                325             


<210> 57
<211> 8147
<212> DNA
<213> Homo sapiens

<400> 57
ggaggaagaa aactcaagtg aaactgactc tgctagaaca gtgccgtgct tttccacaga       60

aggttagacc ctgaaagaga tggctcagca ccacctatgg atcttgctcc tttgcctgca      120

aacctggccg gaagcagctg gaaaagactc agaaatcttc acagtgaatg ggattctggg      180

agagtcagtc actttccctg taaatatcca agaaccacgg caagttaaaa tcattgcttg      240

gacttctaaa acatctgttg cttatgtaac accaggagac tcagaaacag cacccgtagt      300

tactgtgacc cacagaaatt attatgaacg gatacatgcc ttaggtccga actacaatct      360

ggtcattagc gatctgagga tggaagacgc aggagactac aaagcagaca taaatacaca      420

ggctgatccc tacaccacca ccaagcgcta caacctgcaa atctatcgtc ggcttgggaa      480

accaaaaatt acacagagtt taatggcatc tgtgaacagc acctgtaatg tcacactgac      540

atgctctgta gagaaagaag aaaagaatgt gacatacaat tggagtcccc tgggagaaga      600

gggtaatgtc cttcaaatct tccagactcc tgaggaccaa gagctgactt acacgtgtac      660

agcccagaac cctgtcagca acaattctga ctccatctct gcccggcagc tctgtgcaga      720

catcgcaatg ggcttccgta ctcaccacac cgggttgctg agcgtgctgg ctatgttctt      780

tctgcttgtt ctcattctgt cttcagtgtt tttgttccgt ttgttcaaga gaagacaagg      840

tgcttccctc caaggaagag ccagtgaaca cagtttattc cgaagtgcag tttgctgata      900

agatggggaa agccagcaca caggacagta aacctcctgg gacttcaagc tatgaaattg      960

tgatctaggc tgctgggctg aattctccct ctggaaactg agttacaacc accaatactg     1020

gcaggttccc tggatccaga tcttctctgc ccaactctta ctgggagatt gcaaactgcc     1080

acatctcagc ctgtaagcaa agcaggaaac cttctgctgg gcatagcttg tgcctaaatg     1140

gacaaatgga tgcataccct tcctgaaatg actcccttct gaatgaatga caaagcaggt     1200

tacctagtat agttttccca aacttcttcc catcatagca catgtagaaa ataatatttt     1260

tatggcacac tgggataaac aagcaagatt gctcacttct ggaagctgca tatgactaga     1320

ggcctcttgt gactggaggt aacaaccctg cccagtaact gtgggagaag gggatcaata     1380

ttttgcacac ctgtaatagg ccatggcaca ccagccaaga tgctctgctc acagtcagta     1440

tgtgtgaaga tccctggtgc gtggccttca ccacgcatct tgagcaaatt aggaaaatgt     1500

acccttcgct tgaggcagat gcagcccttc ccccgagtgc atggcttgga gagcagaatg     1560

tgggctgcat ataagcacac tcatcccttt gtctgggaat ctttgtgcag ggcataacag     1620

gcttagtaag tccaaacaca gatgacagtg ctgtgtgggt ctctgtcaga gttgtggctc     1680

tcagccatgt agacacactc tccaaatgga gtgttggaaa atgttctttc tgcagggtct     1740

agagactgct gggacacttt tcttggagtg ctacttcaga agccttatag gattttcttt     1800

ctggccaaga tttccttctg tatcactcca agcagcctca gcagaagaag cagccatgcc     1860

cagtattccc actctccaaa aggaactgac cagcttatat ttctcacact tctggggaac     1920

tgggtataat ccaaccatca aaatagaaga ccttgcaaga agcagagtca ttctccagaa     1980

ggaacttggg agatgatggt gcagatgatg aaactgggtt catcccagtt ccaaagactc     2040

agagaactag agtttaagct gaggcagagt gccgccaccc tggcatgccc cacaaacaga     2100

tcaccagcca gcttacacag gcattaactc tcctcaatga ggaagaatca ttcacaactg     2160

agcaagacat tcatatgatc atttaaggaa gtgtttccct tatgtgttag caagtataat     2220

cggctaactc ctaaatccca atgaatagtc ctaggctgga cagcaatggg ctgcaattag     2280

gcagataaag acatcagtcc cagtaaatga atccatagac tcatctagca ccaactacca     2340

ttagcactat gttaggagct gcaaggcccc aaagtagaag atgtgcataa tgtctgctct     2400

tgtgtagctc aggagacaat tccagcacag acactacagt taacgctgaa ctgcagctgc     2460

aagtaatagc atgaacagtc agaaaaatac cttatgaggg ggcagggctg aagctgggcc     2520

ttgaaggatg gatgaaattt ggatagagaa tgaggaagac agagggcctc caagtgagag     2580

aagcatgaaa aatgagcagg ggcctggatc agtggggtgt attcagagca cctctccaga     2640

tgcaccatgc atgctcacag tcccttgcct atgtgtggca gagtgtccca gccagatgtg     2700

tgccctcacc ccatgtccat ttacatgtcc ttcaatgccc acctcaaaag gtacctcttc     2760

tgtaaagctt tccctggtat caggaatcaa aattaatcag ggatcttttc acactgctgt     2820

tttttcctct ttggtccttc tatcactaaa actcatctca ttcagcctta cagcataact     2880

aattatttgt tttcctcact acattgtaca tgtgggaatt acagataaac ggaagccggc     2940

tggggtggtg gctcacgcct gtaatcccaa cactttggga ggccaaggca ggcggatcac     3000

ctgaggtcag gagttcgaga ttagtctggc caacatggtg aaaccccatc tctactaaaa     3060

atacgaaatt agccaggtgt ggtggcacac atctgtagtc ccagctactc tggaggctga     3120

gacaggagaa tcgcttgaac ccaggaagtg gaggttgcag tgagctgaga tcacaccact     3180

gcactccagc ctgggagaga cagagtgaga ctccatctcg aaaaaaaaaa aaagatagaa     3240

gccaataagc atggtgcaat caaattctgg caagcattaa atatcaggat gcagctgggc     3300

acggtggctc acgcctgtaa tcccagcact ttgggaggcc aaggtgggcg gatcacttga     3360

ggtcaggaat ttgagaggat cctggccagc atggcaaaac cccatctgta cttaaaatac     3420

aaaaaaatta gctgggcgtg gtggtgcaca cctgtaatcc cagctacttg ggaggctgag     3480

gtgggagaat tgcttgaacc tgggaggtgg aggttgcagt gagctgagat cctgccactg     3540

cactccaggc tgggcaacag agtgagacca tgtctcaaaa aataaaaata aaataaaata     3600

atatcaggat gcatacatca gaggctgttc ctagtgtaaa ggcactttgg agggagaaga     3660

ctttcagagt taggcagacc aactaagagg tcagctgaag cacctaacca gttgtaagga     3720

ggtgaaagac agcaccccaa gaagagacgt gcaggaagga ggaaagaggc ttggtcataa     3780

aggatggagg aattccaaag tgacactgaa caggctgcgt ttatcctaaa ataaaaccac     3840

tcctcactct gtggatgcgt tgaagactca ttcccaaaca tctttattct ctaacttgcc     3900

ctcttcctct tcctaatatg ctcactcaag taaaattact agtgtcctaa tgcccctatg     3960

catattgtca aaaataaaaa tcagaagcag gttagatctg ttaggtcttc cagaagagca     4020

aacctgggat gaagccagag cccaggaatt ctgaaggtag cctttggact caggacaccc     4080

tactcttgtc tctcctctca gtttctctgc tatgaatctc ctgattcatg aacacgttat     4140

ctgttcaccc ttctctctag gtcttagttc ttagattttc cttctgtaaa atgcatgtga     4200

tcttattttc ccctccacaa ctttccagat gaactagact gtgaccaaga ggtctataaa     4260

atcaaagcat catggaacag gatcttgtat cagaccaaag tgtgccagtt tttaaaaatg     4320

tgcatcaaaa tggaagtctc agagacagag ccctctggtg gaaagttcta gtaggttagg     4380

acagtcctgc ctgcagacac cttgggcttt actgagggac tcaactgaga aaatgaggaa     4440

tgttgcagct catgattctt agaagaagaa agtgaagctt gtttaaaata tgatttaaaa     4500

aatctgtaga acactgtaaa ctacacaggc tatgagggaa tagcctggtt gggccagctt     4560

ggaaatcggg cacaggcagg aaggggcctg tctggtttgg gccgtgtcca cagagagcac     4620

ttcttaggtc ctgcctggag agaaggaatg gctgggctat attttcttcc agactcatta     4680

tttttcttct gtttgacttt tctctgaatt tcccttgatt tgtataaatt ttctcaataa     4740

ttagtgacag tgtctactga ttgtaaaatg aagcttgaag gccaggcgca gtggctcatg     4800

cctgtaatcc tagaattttg ggaggccaag gtgggtggat cacaaggagt tcgagaccag     4860

cctggccaag gttgtgaaac cgcgtctcta ctaaaaatac aaaaaaatta gccgggcatg     4920

gtggcacgtg cctgtagtcc cagctactca ggaagctgag gcaacagaat cacttgaacc     4980

tgggaggtgg aggttgcagt gagccgagat cacgccactg cactccagcc tgggcgagag     5040

agtgagactc cgtctcaaaa aaaaaaaaaa aaaaaaaagt ttgaagaaca aagacaataa     5100

gaggaaatat aatgagtggt cataaatgtg ggctctgaca gtagagtgcc tgggtctgca     5160

tcctggtttc ttagtcatgt gaccttaggc aagttacttt aacctcgctg tacctcaggt     5220

tgtccatctg taaaatgggg ataataatag tgcctacctt ttaaggttga tgtggggatt     5280

aaatgaggtg ttgctcatac aggaatgtgc ctgtgcatgg caaagttcgg gaaatttttt     5340

ataagctgtt ctaggcctga aatcttcaga agatgctaat ctaaattcat gaaataagct     5400

tcttacaaca gaaatgctgc tagtattatg caaaattaat gttgtatatc aaacttttaa     5460

ctctcatccc tccttattca gatatatttt gttataagca atgtttgttc ccctcgttat     5520

tataccacag tctacttacc tgatgctata tctgcctccc cagttagact gagagaacag     5580

gggatatacc taaataataa taataataat aataataata aataataatg gagagctcct     5640

tgaagatagg gagcctgtaa gaatcattga gggcttattt tgtataccaa ctgctaaact     5700

agatgcttca tacattgttg tcaatactca tgacagcctt gtaaagtaga aattaattct     5760

tccagttaac actaaggctg acatatgaat accttggcaa atctggaaag ctgggaagac     5820

agtatttgaa ttcaagactt cttgtcacca agggccatgc acttgtactc tgccatgtgg     5880

ccctttttta cctcctgtgg attctcccta cctggtactt ggccttaggt gtacacacac     5940

ctggcacttt gcttgacaca taataggtgg accacaaata tctactaaat gaatatttgc     6000

atatagtaat attttaaggt actaaaagca gctcaaagta aatatattaa tatattaatt     6060

ccattgctat ctggataacc actcaacttt cctgctgaaa atgcccattt aattaaagaa     6120

ggttggatag agctctctat atgcattttg gacaggcagg ggtttcaggt cataaacatt     6180

ctgatgagtt aatataaaat aagagaaact gtaaatttcc actactaaaa atcacaaaaa     6240

taacagaaac aaaagaagag ataagaattt ggggaattgt gctgaacaat ttagtggtta     6300

aaaaaaacaa ctgtgcatgt ttagacttaa ataagccccc atccaagtgt gaggggtcca     6360

gtaatttttc aaaacatatg aaagtgttaa tacatttcga caaaggacca ttaaaaaagt     6420

cctgaattct gacttgaggg aggaaagtaa tgactaatac attctctaga gacttgcaga     6480

ctttgggaat tcataaagga atggatgata attattaact gttgctggct gattgcccag     6540

acagttctca acagccctgt acaagtctct gggtttggga tggatcaatt ctgagactgg     6600

aaaatggcca aatctttgca aatgagaaat atttttctta taagttctta ttgtaggcaa     6660

ataattacat agattattca tcagagaatt tttaaatgct cataatctca actctttcat     6720

ttacaacttg tatttccaat agtttatggg tcatctctgc atagatgtca gaagtcacct     6780

caagtttagc gtgtccaaaa tctaactcac aggtctgttt ctgacctccc aacttgcttt     6840

ccttgtgttt ttcctatgct aatgatccac cataatcaaa ataattaaca tttatccagt     6900

gcctactatg tactattccc tgtcctgttt tacatttact catttaaagt ccataagaaa     6960

cattaaatct catctgcctt ctgaagaaga tacaaccatg ctctctttta caaagtagga     7020

aactgggtca cagaaaggtg aagtctttaa ggctgaatca cagtagctca tcctagtaaa     7080

tagaaaagcc aggattcaac tccaggggct gggtgcagaa ctgctattct tcactgcttc     7140

accaatcagc agctacccaa ggcagaaaac tttttcatcc ttggctcctt cattctccct     7200

gtcaccccag atcccctcta catctagtca gagaataggt cctgtcaatt ccaacttctc     7260

tatatggctc ctctcaggca tgtgccctta attggcctaa ttctctaata caccttccct     7320

ctacatgctc actccctcag atcattgctt tatcacgtgt tacctgggtt gctattacat     7380

aaagagcaat ctttctaaaa tgaggatctt atcacttcac ttccacacta aaatgttttt     7440

cctggggaac cacactcctt agcaatctga cccatcagac cttccaggct gtctcctgcc     7500

tgctccctaa ggctccagcc acacagaatt atcatgggcc cacacaccca ccaaatcctc     7560

ccatgccttt gcccatgttg tctgggatgc ccttctctcc cttctgtcta catcaagcat     7620

cagactgaat atccctcttg tgcggccttc taaaacctcc cgtccaaagc gaaatatatt     7680

gccctctatt tatactttta cagcatttgg cacacaagta cagagtagta gctttttatc     7740

acattctctg ataattatat agatatggta tttcttagct ctctctccaa ctggctaata     7800

agttgctttt tgtctgagtg cctaattttg tgttttgtgt ctgagtgcct cagttcctca     7860

aaaaaaggtt ttttgattag ttcattattc atttgaacat ggaaattatg ctcactagtg     7920

gcaaatgcca ctaaccgtat tccagaagct aggtgtcatg tttgcaataa gatatattat     7980

cccttctaca agtcaccttt tatttcaggc atttgtaaat gcccattaat aaagtatggt     8040

tcataaattt taccttgtaa gtgcctaaga aatgagacta caagctccat ttcagcagga     8100

cacaataaat attattttat aatgcatcta aaaaaaaaaa aaaaaaa                   8147


<210> 58
<211> 272
<212> PRT
<213> Homo sapiens

<400> 58
Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Gly Ala Ser 
                245                 250                 255     


Leu Gln Gly Arg Ala Ser Glu His Ser Leu Phe Arg Ser Ala Val Cys 
            260                 265                 270         


<210> 59
<211> 7903
<212> DNA
<213> Homo sapiens

<400> 59
ggaggaagaa aactcaagtg aaactgactc tgctagaaca gtgccgtgct tttccacaga       60

aggttagacc ctgaaagaga tggctcagca ccacctatgg atcttgctcc tttgcctgca      120

aacctgtcgg cttgggaaac caaaaattac acagagttta atggcatctg tgaacagcac      180

ctgtaatgtc acactgacat gctctgtaga gaaagaagaa aagaatgtga catacaattg      240

gagtcccctg ggagaagagg gtaatgtcct tcaaatcttc cagactcctg aggaccaaga      300

gctgacttac acgtgtacag cccagaaccc tgtcagcaac aattctgact ccatctctgc      360

ccggcagctc tgtgcagaca tcgcaatggg cttccgtact caccacaccg ggttgctgag      420

cgtgctggct atgttctttc tgcttgttct cattctgtct tcagtgtttt tgttccgttt      480

gttcaagaga agacaagatg ctgcctcaaa gaaaaccata tacacatata tcatggcttc      540

aaggaacacc cagccagcag agtccagaat ctatgatgaa atcctgcagt ccaaggtgct      600

tccctccaag gaagagccag tgaacacagt ttattccgaa gtgcagtttg ctgataagat      660

ggggaaagcc agcacacagg acagtaaacc tcctgggact tcaagctatg aaattgtgat      720

ctaggctgct gggctgaatt ctccctctgg aaactgagtt acaaccacca atactggcag      780

gttccctgga tccagatctt ctctgcccaa ctcttactgg gagattgcaa actgccacat      840

ctcagcctgt aagcaaagca ggaaaccttc tgctgggcat agcttgtgcc taaatggaca      900

aatggatgca tacccttcct gaaatgactc ccttctgaat gaatgacaaa gcaggttacc      960

tagtatagtt ttcccaaact tcttcccatc atagcacatg tagaaaataa tatttttatg     1020

gcacactggg ataaacaagc aagattgctc acttctggaa gctgcatatg actagaggcc     1080

tcttgtgact ggaggtaaca accctgccca gtaactgtgg gagaagggga tcaatatttt     1140

gcacacctgt aataggccat ggcacaccag ccaagatgct ctgctcacag tcagtatgtg     1200

tgaagatccc tggtgcgtgg ccttcaccac gcatcttgag caaattagga aaatgtaccc     1260

ttcgcttgag gcagatgcag cccttccccc gagtgcatgg cttggagagc agaatgtggg     1320

ctgcatataa gcacactcat ccctttgtct gggaatcttt gtgcagggca taacaggctt     1380

agtaagtcca aacacagatg acagtgctgt gtgggtctct gtcagagttg tggctctcag     1440

ccatgtagac acactctcca aatggagtgt tggaaaatgt tctttctgca gggtctagag     1500

actgctggga cacttttctt ggagtgctac ttcagaagcc ttataggatt ttctttctgg     1560

ccaagatttc cttctgtatc actccaagca gcctcagcag aagaagcagc catgcccagt     1620

attcccactc tccaaaagga actgaccagc ttatatttct cacacttctg gggaactggg     1680

tataatccaa ccatcaaaat agaagacctt gcaagaagca gagtcattct ccagaaggaa     1740

cttgggagat gatggtgcag atgatgaaac tgggttcatc ccagttccaa agactcagag     1800

aactagagtt taagctgagg cagagtgccg ccaccctggc atgccccaca aacagatcac     1860

cagccagctt acacaggcat taactctcct caatgaggaa gaatcattca caactgagca     1920

agacattcat atgatcattt aaggaagtgt ttcccttatg tgttagcaag tataatcggc     1980

taactcctaa atcccaatga atagtcctag gctggacagc aatgggctgc aattaggcag     2040

ataaagacat cagtcccagt aaatgaatcc atagactcat ctagcaccaa ctaccattag     2100

cactatgtta ggagctgcaa ggccccaaag tagaagatgt gcataatgtc tgctcttgtg     2160

tagctcagga gacaattcca gcacagacac tacagttaac gctgaactgc agctgcaagt     2220

aatagcatga acagtcagaa aaatacctta tgagggggca gggctgaagc tgggccttga     2280

aggatggatg aaatttggat agagaatgag gaagacagag ggcctccaag tgagagaagc     2340

atgaaaaatg agcaggggcc tggatcagtg gggtgtattc agagcacctc tccagatgca     2400

ccatgcatgc tcacagtccc ttgcctatgt gtggcagagt gtcccagcca gatgtgtgcc     2460

ctcaccccat gtccatttac atgtccttca atgcccacct caaaaggtac ctcttctgta     2520

aagctttccc tggtatcagg aatcaaaatt aatcagggat cttttcacac tgctgttttt     2580

tcctctttgg tccttctatc actaaaactc atctcattca gccttacagc ataactaatt     2640

atttgttttc ctcactacat tgtacatgtg ggaattacag ataaacggaa gccggctggg     2700

gtggtggctc acgcctgtaa tcccaacact ttgggaggcc aaggcaggcg gatcacctga     2760

ggtcaggagt tcgagattag tctggccaac atggtgaaac cccatctcta ctaaaaatac     2820

gaaattagcc aggtgtggtg gcacacatct gtagtcccag ctactctgga ggctgagaca     2880

ggagaatcgc ttgaacccag gaagtggagg ttgcagtgag ctgagatcac accactgcac     2940

tccagcctgg gagagacaga gtgagactcc atctcgaaaa aaaaaaaaag atagaagcca     3000

ataagcatgg tgcaatcaaa ttctggcaag cattaaatat caggatgcag ctgggcacgg     3060

tggctcacgc ctgtaatccc agcactttgg gaggccaagg tgggcggatc acttgaggtc     3120

aggaatttga gaggatcctg gccagcatgg caaaacccca tctgtactta aaatacaaaa     3180

aaattagctg ggcgtggtgg tgcacacctg taatcccagc tacttgggag gctgaggtgg     3240

gagaattgct tgaacctggg aggtggaggt tgcagtgagc tgagatcctg ccactgcact     3300

ccaggctggg caacagagtg agaccatgtc tcaaaaaata aaaataaaat aaaataatat     3360

caggatgcat acatcagagg ctgttcctag tgtaaaggca ctttggaggg agaagacttt     3420

cagagttagg cagaccaact aagaggtcag ctgaagcacc taaccagttg taaggaggtg     3480

aaagacagca ccccaagaag agacgtgcag gaaggaggaa agaggcttgg tcataaagga     3540

tggaggaatt ccaaagtgac actgaacagg ctgcgtttat cctaaaataa aaccactcct     3600

cactctgtgg atgcgttgaa gactcattcc caaacatctt tattctctaa cttgccctct     3660

tcctcttcct aatatgctca ctcaagtaaa attactagtg tcctaatgcc cctatgcata     3720

ttgtcaaaaa taaaaatcag aagcaggtta gatctgttag gtcttccaga agagcaaacc     3780

tgggatgaag ccagagccca ggaattctga aggtagcctt tggactcagg acaccctact     3840

cttgtctctc ctctcagttt ctctgctatg aatctcctga ttcatgaaca cgttatctgt     3900

tcacccttct ctctaggtct tagttcttag attttccttc tgtaaaatgc atgtgatctt     3960

attttcccct ccacaacttt ccagatgaac tagactgtga ccaagaggtc tataaaatca     4020

aagcatcatg gaacaggatc ttgtatcaga ccaaagtgtg ccagttttta aaaatgtgca     4080

tcaaaatgga agtctcagag acagagccct ctggtggaaa gttctagtag gttaggacag     4140

tcctgcctgc agacaccttg ggctttactg agggactcaa ctgagaaaat gaggaatgtt     4200

gcagctcatg attcttagaa gaagaaagtg aagcttgttt aaaatatgat ttaaaaaatc     4260

tgtagaacac tgtaaactac acaggctatg agggaatagc ctggttgggc cagcttggaa     4320

atcgggcaca ggcaggaagg ggcctgtctg gtttgggccg tgtccacaga gagcacttct     4380

taggtcctgc ctggagagaa ggaatggctg ggctatattt tcttccagac tcattatttt     4440

tcttctgttt gacttttctc tgaatttccc ttgatttgta taaattttct caataattag     4500

tgacagtgtc tactgattgt aaaatgaagc ttgaaggcca ggcgcagtgg ctcatgcctg     4560

taatcctaga attttgggag gccaaggtgg gtggatcaca aggagttcga gaccagcctg     4620

gccaaggttg tgaaaccgcg tctctactaa aaatacaaaa aaattagccg ggcatggtgg     4680

cacgtgcctg tagtcccagc tactcaggaa gctgaggcaa cagaatcact tgaacctggg     4740

aggtggaggt tgcagtgagc cgagatcacg ccactgcact ccagcctggg cgagagagtg     4800

agactccgtc tcaaaaaaaa aaaaaaaaaa aaaagtttga agaacaaaga caataagagg     4860

aaatataatg agtggtcata aatgtgggct ctgacagtag agtgcctggg tctgcatcct     4920

ggtttcttag tcatgtgacc ttaggcaagt tactttaacc tcgctgtacc tcaggttgtc     4980

catctgtaaa atggggataa taatagtgcc taccttttaa ggttgatgtg gggattaaat     5040

gaggtgttgc tcatacagga atgtgcctgt gcatggcaaa gttcgggaaa ttttttataa     5100

gctgttctag gcctgaaatc ttcagaagat gctaatctaa attcatgaaa taagcttctt     5160

acaacagaaa tgctgctagt attatgcaaa attaatgttg tatatcaaac ttttaactct     5220

catccctcct tattcagata tattttgtta taagcaatgt ttgttcccct cgttattata     5280

ccacagtcta cttacctgat gctatatctg cctccccagt tagactgaga gaacagggga     5340

tatacctaaa taataataat aataataata ataataaata ataatggaga gctccttgaa     5400

gatagggagc ctgtaagaat cattgagggc ttattttgta taccaactgc taaactagat     5460

gcttcataca ttgttgtcaa tactcatgac agccttgtaa agtagaaatt aattcttcca     5520

gttaacacta aggctgacat atgaatacct tggcaaatct ggaaagctgg gaagacagta     5580

tttgaattca agacttcttg tcaccaaggg ccatgcactt gtactctgcc atgtggccct     5640

tttttacctc ctgtggattc tccctacctg gtacttggcc ttaggtgtac acacacctgg     5700

cactttgctt gacacataat aggtggacca caaatatcta ctaaatgaat atttgcatat     5760

agtaatattt taaggtacta aaagcagctc aaagtaaata tattaatata ttaattccat     5820

tgctatctgg ataaccactc aactttcctg ctgaaaatgc ccatttaatt aaagaaggtt     5880

ggatagagct ctctatatgc attttggaca ggcaggggtt tcaggtcata aacattctga     5940

tgagttaata taaaataaga gaaactgtaa atttccacta ctaaaaatca caaaaataac     6000

agaaacaaaa gaagagataa gaatttgggg aattgtgctg aacaatttag tggttaaaaa     6060

aaacaactgt gcatgtttag acttaaataa gcccccatcc aagtgtgagg ggtccagtaa     6120

tttttcaaaa catatgaaag tgttaataca tttcgacaaa ggaccattaa aaaagtcctg     6180

aattctgact tgagggagga aagtaatgac taatacattc tctagagact tgcagacttt     6240

gggaattcat aaaggaatgg atgataatta ttaactgttg ctggctgatt gcccagacag     6300

ttctcaacag ccctgtacaa gtctctgggt ttgggatgga tcaattctga gactggaaaa     6360

tggccaaatc tttgcaaatg agaaatattt ttcttataag ttcttattgt aggcaaataa     6420

ttacatagat tattcatcag agaattttta aatgctcata atctcaactc tttcatttac     6480

aacttgtatt tccaatagtt tatgggtcat ctctgcatag atgtcagaag tcacctcaag     6540

tttagcgtgt ccaaaatcta actcacaggt ctgtttctga cctcccaact tgctttcctt     6600

gtgtttttcc tatgctaatg atccaccata atcaaaataa ttaacattta tccagtgcct     6660

actatgtact attccctgtc ctgttttaca tttactcatt taaagtccat aagaaacatt     6720

aaatctcatc tgccttctga agaagataca accatgctct cttttacaaa gtaggaaact     6780

gggtcacaga aaggtgaagt ctttaaggct gaatcacagt agctcatcct agtaaataga     6840

aaagccagga ttcaactcca ggggctgggt gcagaactgc tattcttcac tgcttcacca     6900

atcagcagct acccaaggca gaaaactttt tcatccttgg ctccttcatt ctccctgtca     6960

ccccagatcc cctctacatc tagtcagaga ataggtcctg tcaattccaa cttctctata     7020

tggctcctct caggcatgtg cccttaattg gcctaattct ctaatacacc ttccctctac     7080

atgctcactc cctcagatca ttgctttatc acgtgttacc tgggttgcta ttacataaag     7140

agcaatcttt ctaaaatgag gatcttatca cttcacttcc acactaaaat gtttttcctg     7200

gggaaccaca ctccttagca atctgaccca tcagaccttc caggctgtct cctgcctgct     7260

ccctaaggct ccagccacac agaattatca tgggcccaca cacccaccaa atcctcccat     7320

gcctttgccc atgttgtctg ggatgccctt ctctcccttc tgtctacatc aagcatcaga     7380

ctgaatatcc ctcttgtgcg gccttctaaa acctcccgtc caaagcgaaa tatattgccc     7440

tctatttata cttttacagc atttggcaca caagtacaga gtagtagctt tttatcacat     7500

tctctgataa ttatatagat atggtatttc ttagctctct ctccaactgg ctaataagtt     7560

gctttttgtc tgagtgccta attttgtgtt ttgtgtctga gtgcctcagt tcctcaaaaa     7620

aaggtttttt gattagttca ttattcattt gaacatggaa attatgctca ctagtggcaa     7680

atgccactaa ccgtattcca gaagctaggt gtcatgtttg caataagata tattatccct     7740

tctacaagtc accttttatt tcaggcattt gtaaatgccc attaataaag tatggttcat     7800

aaattttacc ttgtaagtgc ctaagaaatg agactacaag ctccatttca gcaggacaca     7860

ataaatatta ttttataatg catctaaaaa aaaaaaaaaa aaa                       7903


<210> 60
<211> 214
<212> PRT
<213> Homo sapiens

<400> 60
Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Cys 
1               5                   10                  15      


Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser Val Asn 
            20                  25                  30          


Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu Glu Lys 
        35                  40                  45              


Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn Val Leu 
    50                  55                  60                  


Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr Cys Thr 
65                  70                  75                  80  


Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala Arg Gln 
                85                  90                  95      


Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr Gly Leu 
            100                 105                 110         


Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu Ser Ser 
        115                 120                 125             


Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Asp Ala Ala Ser Lys 
    130                 135                 140                 


Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln Pro Ala 
145                 150                 155                 160 


Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu Pro Ser 
                165                 170                 175     


Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe Ala Asp 
            180                 185                 190         


Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly Thr Ser 
        195                 200                 205             


Ser Tyr Glu Ile Val Ile 
    210                 


<210> 61
<211> 8261
<212> DNA
<213> Homo sapiens

<400> 61
ggaggaagaa aactcaagtg aaactgactc tgctagaaca gtgccgtgct tttccacaga       60

aggttagacc ctgaaagaga tggctcagca ccacctatgg atcttgctcc tttgcctgca      120

aacctggccg gaagcagctg gaaaagactc agaaatcttc acagtgaatg ggattctggg      180

agagtcagtc actttccctg taaatatcca agaaccacgg caagttaaaa tcattgcttg      240

gacttctaaa acatctgttg cttatgtaac accaggagac tcagaaacag cacccgtagt      300

tactgtgacc cacagaaatt attatgaacg gatacatgcc ttaggtccga actacaatct      360

ggtcattagc gatctgagga tggaagacgc aggagactac aaagcagaca taaatacaca      420

ggctgatccc tacaccacca ccaagcgcta caacctgcaa atctatcgtc ggcttgggaa      480

accaaaaatt acacagagtt taatggcatc tgtgaacagc acctgtaatg tcacactgac      540

atgctctgta gagaaagaag aaaagaatgt gacatacaat tggagtcccc tgggagaaga      600

gggtaatgtc cttcaaatct tccagactcc tgaggaccaa gagctgactt acacgtgtac      660

agcccagaac cctgtcagca acaattctga ctccatctct gcccggcagc tctgtgcaga      720

catcgcaatg ggcttccgta ctcaccacac cgggttgctg agcgtgctgg ctatgttctt      780

tctgcttgtt ctcattctgt cttcagtgtt tttgttccgt ttgttcaaga gaagacaagg      840

ttcctgcttg aacaccttca ctaagaaccc ttatgctgcc tcaaagaaaa ccatatacac      900

atatatcatg gcttcaagga acacccagcc agcagagtcc agaatctatg atgaaatcct      960

gcagtccaag gtgcttccct ccaaggaaga gccagtgaac acagtttatt ccgaagtgca     1020

gtttgctgat aagatgggga aagccagcac acaggacagt aaacctcctg ggacttcaag     1080

ctatgaaatt gtgatctagg ctgctgggct gaattctccc tctggaaact gagttacaac     1140

caccaatact ggcaggttcc ctggatccag atcttctctg cccaactctt actgggagat     1200

tgcaaactgc cacatctcag cctgtaagca aagcaggaaa ccttctgctg ggcatagctt     1260

gtgcctaaat ggacaaatgg atgcataccc ttcctgaaat gactcccttc tgaatgaatg     1320

acaaagcagg ttacctagta tagttttccc aaacttcttc ccatcatagc acatgtagaa     1380

aataatattt ttatggcaca ctgggataaa caagcaagat tgctcacttc tggaagctgc     1440

atatgactag aggcctcttg tgactggagg taacaaccct gcccagtaac tgtgggagaa     1500

ggggatcaat attttgcaca cctgtaatag gccatggcac accagccaag atgctctgct     1560

cacagtcagt atgtgtgaag atccctggtg cgtggccttc accacgcatc ttgagcaaat     1620

taggaaaatg tacccttcgc ttgaggcaga tgcagccctt cccccgagtg catggcttgg     1680

agagcagaat gtgggctgca tataagcaca ctcatccctt tgtctgggaa tctttgtgca     1740

gggcataaca ggcttagtaa gtccaaacac agatgacagt gctgtgtggg tctctgtcag     1800

agttgtggct ctcagccatg tagacacact ctccaaatgg agtgttggaa aatgttcttt     1860

ctgcagggtc tagagactgc tgggacactt ttcttggagt gctacttcag aagccttata     1920

ggattttctt tctggccaag atttccttct gtatcactcc aagcagcctc agcagaagaa     1980

gcagccatgc ccagtattcc cactctccaa aaggaactga ccagcttata tttctcacac     2040

ttctggggaa ctgggtataa tccaaccatc aaaatagaag accttgcaag aagcagagtc     2100

attctccaga aggaacttgg gagatgatgg tgcagatgat gaaactgggt tcatcccagt     2160

tccaaagact cagagaacta gagtttaagc tgaggcagag tgccgccacc ctggcatgcc     2220

ccacaaacag atcaccagcc agcttacaca ggcattaact ctcctcaatg aggaagaatc     2280

attcacaact gagcaagaca ttcatatgat catttaagga agtgtttccc ttatgtgtta     2340

gcaagtataa tcggctaact cctaaatccc aatgaatagt cctaggctgg acagcaatgg     2400

gctgcaatta ggcagataaa gacatcagtc ccagtaaatg aatccataga ctcatctagc     2460

accaactacc attagcacta tgttaggagc tgcaaggccc caaagtagaa gatgtgcata     2520

atgtctgctc ttgtgtagct caggagacaa ttccagcaca gacactacag ttaacgctga     2580

actgcagctg caagtaatag catgaacagt cagaaaaata ccttatgagg gggcagggct     2640

gaagctgggc cttgaaggat ggatgaaatt tggatagaga atgaggaaga cagagggcct     2700

ccaagtgaga gaagcatgaa aaatgagcag gggcctggat cagtggggtg tattcagagc     2760

acctctccag atgcaccatg catgctcaca gtcccttgcc tatgtgtggc agagtgtccc     2820

agccagatgt gtgccctcac cccatgtcca tttacatgtc cttcaatgcc cacctcaaaa     2880

ggtacctctt ctgtaaagct ttccctggta tcaggaatca aaattaatca gggatctttt     2940

cacactgctg ttttttcctc tttggtcctt ctatcactaa aactcatctc attcagcctt     3000

acagcataac taattatttg ttttcctcac tacattgtac atgtgggaat tacagataaa     3060

cggaagccgg ctggggtggt ggctcacgcc tgtaatccca acactttggg aggccaaggc     3120

aggcggatca cctgaggtca ggagttcgag attagtctgg ccaacatggt gaaaccccat     3180

ctctactaaa aatacgaaat tagccaggtg tggtggcaca catctgtagt cccagctact     3240

ctggaggctg agacaggaga atcgcttgaa cccaggaagt ggaggttgca gtgagctgag     3300

atcacaccac tgcactccag cctgggagag acagagtgag actccatctc gaaaaaaaaa     3360

aaaagataga agccaataag catggtgcaa tcaaattctg gcaagcatta aatatcagga     3420

tgcagctggg cacggtggct cacgcctgta atcccagcac tttgggaggc caaggtgggc     3480

ggatcacttg aggtcaggaa tttgagagga tcctggccag catggcaaaa ccccatctgt     3540

acttaaaata caaaaaaatt agctgggcgt ggtggtgcac acctgtaatc ccagctactt     3600

gggaggctga ggtgggagaa ttgcttgaac ctgggaggtg gaggttgcag tgagctgaga     3660

tcctgccact gcactccagg ctgggcaaca gagtgagacc atgtctcaaa aaataaaaat     3720

aaaataaaat aatatcagga tgcatacatc agaggctgtt cctagtgtaa aggcactttg     3780

gagggagaag actttcagag ttaggcagac caactaagag gtcagctgaa gcacctaacc     3840

agttgtaagg aggtgaaaga cagcacccca agaagagacg tgcaggaagg aggaaagagg     3900

cttggtcata aaggatggag gaattccaaa gtgacactga acaggctgcg tttatcctaa     3960

aataaaacca ctcctcactc tgtggatgcg ttgaagactc attcccaaac atctttattc     4020

tctaacttgc cctcttcctc ttcctaatat gctcactcaa gtaaaattac tagtgtccta     4080

atgcccctat gcatattgtc aaaaataaaa atcagaagca ggttagatct gttaggtctt     4140

ccagaagagc aaacctggga tgaagccaga gcccaggaat tctgaaggta gcctttggac     4200

tcaggacacc ctactcttgt ctctcctctc agtttctctg ctatgaatct cctgattcat     4260

gaacacgtta tctgttcacc cttctctcta ggtcttagtt cttagatttt ccttctgtaa     4320

aatgcatgtg atcttatttt cccctccaca actttccaga tgaactagac tgtgaccaag     4380

aggtctataa aatcaaagca tcatggaaca ggatcttgta tcagaccaaa gtgtgccagt     4440

ttttaaaaat gtgcatcaaa atggaagtct cagagacaga gccctctggt ggaaagttct     4500

agtaggttag gacagtcctg cctgcagaca ccttgggctt tactgaggga ctcaactgag     4560

aaaatgagga atgttgcagc tcatgattct tagaagaaga aagtgaagct tgtttaaaat     4620

atgatttaaa aaatctgtag aacactgtaa actacacagg ctatgaggga atagcctggt     4680

tgggccagct tggaaatcgg gcacaggcag gaaggggcct gtctggtttg ggccgtgtcc     4740

acagagagca cttcttaggt cctgcctgga gagaaggaat ggctgggcta tattttcttc     4800

cagactcatt atttttcttc tgtttgactt ttctctgaat ttcccttgat ttgtataaat     4860

tttctcaata attagtgaca gtgtctactg attgtaaaat gaagcttgaa ggccaggcgc     4920

agtggctcat gcctgtaatc ctagaatttt gggaggccaa ggtgggtgga tcacaaggag     4980

ttcgagacca gcctggccaa ggttgtgaaa ccgcgtctct actaaaaata caaaaaaatt     5040

agccgggcat ggtggcacgt gcctgtagtc ccagctactc aggaagctga ggcaacagaa     5100

tcacttgaac ctgggaggtg gaggttgcag tgagccgaga tcacgccact gcactccagc     5160

ctgggcgaga gagtgagact ccgtctcaaa aaaaaaaaaa aaaaaaaaag tttgaagaac     5220

aaagacaata agaggaaata taatgagtgg tcataaatgt gggctctgac agtagagtgc     5280

ctgggtctgc atcctggttt cttagtcatg tgaccttagg caagttactt taacctcgct     5340

gtacctcagg ttgtccatct gtaaaatggg gataataata gtgcctacct tttaaggttg     5400

atgtggggat taaatgaggt gttgctcata caggaatgtg cctgtgcatg gcaaagttcg     5460

ggaaattttt tataagctgt tctaggcctg aaatcttcag aagatgctaa tctaaattca     5520

tgaaataagc ttcttacaac agaaatgctg ctagtattat gcaaaattaa tgttgtatat     5580

caaactttta actctcatcc ctccttattc agatatattt tgttataagc aatgtttgtt     5640

cccctcgtta ttataccaca gtctacttac ctgatgctat atctgcctcc ccagttagac     5700

tgagagaaca ggggatatac ctaaataata ataataataa taataataat aaataataat     5760

ggagagctcc ttgaagatag ggagcctgta agaatcattg agggcttatt ttgtatacca     5820

actgctaaac tagatgcttc atacattgtt gtcaatactc atgacagcct tgtaaagtag     5880

aaattaattc ttccagttaa cactaaggct gacatatgaa taccttggca aatctggaaa     5940

gctgggaaga cagtatttga attcaagact tcttgtcacc aagggccatg cacttgtact     6000

ctgccatgtg gccctttttt acctcctgtg gattctccct acctggtact tggccttagg     6060

tgtacacaca cctggcactt tgcttgacac ataataggtg gaccacaaat atctactaaa     6120

tgaatatttg catatagtaa tattttaagg tactaaaagc agctcaaagt aaatatatta     6180

atatattaat tccattgcta tctggataac cactcaactt tcctgctgaa aatgcccatt     6240

taattaaaga aggttggata gagctctcta tatgcatttt ggacaggcag gggtttcagg     6300

tcataaacat tctgatgagt taatataaaa taagagaaac tgtaaatttc cactactaaa     6360

aatcacaaaa ataacagaaa caaaagaaga gataagaatt tggggaattg tgctgaacaa     6420

tttagtggtt aaaaaaaaca actgtgcatg tttagactta aataagcccc catccaagtg     6480

tgaggggtcc agtaattttt caaaacatat gaaagtgtta atacatttcg acaaaggacc     6540

attaaaaaag tcctgaattc tgacttgagg gaggaaagta atgactaata cattctctag     6600

agacttgcag actttgggaa ttcataaagg aatggatgat aattattaac tgttgctggc     6660

tgattgccca gacagttctc aacagccctg tacaagtctc tgggtttggg atggatcaat     6720

tctgagactg gaaaatggcc aaatctttgc aaatgagaaa tatttttctt ataagttctt     6780

attgtaggca aataattaca tagattattc atcagagaat ttttaaatgc tcataatctc     6840

aactctttca tttacaactt gtatttccaa tagtttatgg gtcatctctg catagatgtc     6900

agaagtcacc tcaagtttag cgtgtccaaa atctaactca caggtctgtt tctgacctcc     6960

caacttgctt tccttgtgtt tttcctatgc taatgatcca ccataatcaa aataattaac     7020

atttatccag tgcctactat gtactattcc ctgtcctgtt ttacatttac tcatttaaag     7080

tccataagaa acattaaatc tcatctgcct tctgaagaag atacaaccat gctctctttt     7140

acaaagtagg aaactgggtc acagaaaggt gaagtcttta aggctgaatc acagtagctc     7200

atcctagtaa atagaaaagc caggattcaa ctccaggggc tgggtgcaga actgctattc     7260

ttcactgctt caccaatcag cagctaccca aggcagaaaa ctttttcatc cttggctcct     7320

tcattctccc tgtcacccca gatcccctct acatctagtc agagaatagg tcctgtcaat     7380

tccaacttct ctatatggct cctctcaggc atgtgccctt aattggccta attctctaat     7440

acaccttccc tctacatgct cactccctca gatcattgct ttatcacgtg ttacctgggt     7500

tgctattaca taaagagcaa tctttctaaa atgaggatct tatcacttca cttccacact     7560

aaaatgtttt tcctggggaa ccacactcct tagcaatctg acccatcaga ccttccaggc     7620

tgtctcctgc ctgctcccta aggctccagc cacacagaat tatcatgggc ccacacaccc     7680

accaaatcct cccatgcctt tgcccatgtt gtctgggatg cccttctctc ccttctgtct     7740

acatcaagca tcagactgaa tatccctctt gtgcggcctt ctaaaacctc ccgtccaaag     7800

cgaaatatat tgccctctat ttatactttt acagcatttg gcacacaagt acagagtagt     7860

agctttttat cacattctct gataattata tagatatggt atttcttagc tctctctcca     7920

actggctaat aagttgcttt ttgtctgagt gcctaatttt gtgttttgtg tctgagtgcc     7980

tcagttcctc aaaaaaaggt tttttgatta gttcattatt catttgaaca tggaaattat     8040

gctcactagt ggcaaatgcc actaaccgta ttccagaagc taggtgtcat gtttgcaata     8100

agatatatta tcccttctac aagtcacctt ttatttcagg catttgtaaa tgcccattaa     8160

taaagtatgg ttcataaatt ttaccttgta agtgcctaag aaatgagact acaagctcca     8220

tttcagcagg acacaataaa tattatttta taatgcatct a                         8261


<210> 62
<211> 339
<212> PRT
<213> Homo sapiens

<400> 62
Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Gly Ser Cys 
                245                 250                 255     


Leu Asn Thr Phe Thr Lys Asn Pro Tyr Ala Ala Ser Lys Lys Thr Ile 
            260                 265                 270         


Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln Pro Ala Glu Ser Arg 
        275                 280                 285             


Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu Pro Ser Lys Glu Glu 
    290                 295                 300                 


Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe Ala Asp Lys Met Gly 
305                 310                 315                 320 


Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly Thr Ser Ser Tyr Glu 
                325                 330                 335     


Ile Val Ile 
            


<210> 63
<211> 3290
<212> DNA
<213> Mus musculus

<400> 63
agtgcttgga gttcctctgt gactgaccac ttcttccttt tctgtctaat ggtgaacacc       60

tttctggacc agctctggac cagaatctga tttatgctct gctccggaaa caccacactg      120

aagtgaaagc agctaccaca ccagttattt ttcctcagaa gactggagtc tgactggaca      180

tggcccagcg ccatctgtgg atctggttcc tttgcctaca aacctggtct gaagcagcag      240

gaaaagatgc agacccggtg gtaatgaatg ggattcttgg ggagtcagtt actttcctct      300

taaatattca agaaccaaag aaaattgaca acattgcctg gacttctcaa tcatctgttg      360

cttttataaa accaggagtc aataaagctg aagttaccat aacccagggc acttataaag      420

gacgaataga aatcatagat cagaagtatg acctggtcat tagagacctg aggatggaag      480

atgcaggaac ttacaaagca gacatcaatg aagagaatga ggaaaccatc accaagatct      540

actaccttca tatctaccgt cgacttaaaa caccaaaaat tacacagagt ttgatatcat      600

ctttgaacaa tacctgtaat atcacactga catgctctgt ggaaaaggaa gaaaaggatg      660

tcacatatag ctggagtccc tttggagaga aaagcaatgt ccttcaaatc gtccactccc      720

ccatggacca aaaactgacc tacacatgta cagcccagaa ccctgtcagc aacagttctg      780

actctgtcac tgtccagcag ccatgtacag acactccaag cttccatcct cgccatgctg      840

tgttgccagg aggattggcc gtgctctttc tgcttattct cattccgatg ttggcatttc      900

tgttccgttt gtataagaga aggcgagaca ggattgtcct ggaagcagat gatgtctcaa      960

agaaaacagt atatgctgta gtttcaagaa atgctcaacc cacagagtcc agaatctatg     1020

atgaaatccc tcagtccaag atgctgtcct gtaagaaaga tccggtgacc accatttatt     1080

cctcagtgca gctttctgag aagatgaagg aaaccaacat gaaggacaga agtctgccta     1140

aggctttggg taatgaaatt gttgtctagg tgattctcta agaccacgaa ggacacaagg     1200

acaagtcatc tatgaggatt gaatcaacgg tttcagtctt ttggatataa cctgggccag     1260

ccaagggatt taggaatgaa gcaagctccg tgggtagagg tctgatcccc agtgtgtaat     1320

gttaggggcc atgtacagga ttgactctca ggcccacaga tctttaccca gagaaaccct     1380

gacctgctcc catgctgttt ttcctgggga aaggacccta gggcactcaa cctttatgca     1440

atcagacatg cctctcagag actgtctaac agcttccaga ctaatctctg tgcagtactt     1500

agtcttacaa ctctcacggg caacggcttc aagttccaat tttacgatgt gtctagcctg     1560

ggatgactgt ttagtttcta atgtggcgag aatgtatgtt accatgtagg aagcacagac     1620

tatggcaatc tataaatgat ttgtggcatg agactgatgt ccgaatttag gggaagggga     1680

atggtcttac ttaggcattt tatggaaatt gagtctctct ccccgagaag agggtgatga     1740

agcagcatcc acgtctgcct cttctccagt aacctgcttg ttatcgacaa tgtccagccg     1800

atggtaatga actgaaacaa atgcgcttga aagagatgaa tcaatttgag atttaacaaa     1860

tcgggtcaat ttctgaaatg cccaaggacc gaaggagatc aataatagga gtcccaatag     1920

gggccctaaa agggagggca acaaggttga aagtcagggg gaggttgaaa accagttttg     1980

gtagtctacc ttccccctag gccattgtaa atacttgtgt atgggtgtaa ctcagctatc     2040

tatagttcta agtatccact ctggttcctc tttaggtctt aaacttcctt cttcctagtt     2100

gatggtaaat tcctgtgtaa ggcagtggcc tagcttttat tcaaagtgat agtgtaatgc     2160

cagaggctat tctgaatgtc actgaatagg caacactctc cctgaattct aagtccatgg     2220

tctgttcaag ggctttttag gacattggaa caccagtgaa ggcttagcta tgtcagaatt     2280

caatcttaaa atgcacttat aataagataa tattaaaaga gagcacatgg atctatacac     2340

cagactaact cgggaataga atatgagtac aaaatgggca gtatgcagct gctgaactaa     2400

ggctgtggta gatacctttt caaagtttgc attcccagat ttttaaacca aggatcgttt     2460

cctaactcta ataggcagca aaacgtaagc aggtctctaa caaaaacata acagtagatt     2520

ccttatctaa attaggatct acacaattag ttaattgaca agaattacaa tgaatataaa     2580

aagacttgcc aagattggcg atcttaactc ttaaaattat ctaacaataa gcatataggt     2640

aaggtacaca aactttcata gctataagga gctgacctga aaggccaaaa acagtgtctc     2700

tgacaaaagc atcttgtaca ttctctgtac cagtcttttt gcctcatgag tcagcttttt     2760

tagttgtttt tattttaagt tggcaccagg ttggtactcc ttgctgcagc ccatggcgga     2820

gatacgaagt ttctttatct gtttgtaagt ggctgctctc tgatttctct tcttttgtat     2880

actcaacata gctttctggt caccactgtc agggcactca caggtcacag gtcagcctgt     2940

cacattggaa gctagcatgc tcttgtagca ttctgtggaa aaaacagaaa cattctccct     3000

tttccccata ttaagtatct gaacaggatc atggcaagtg ccaataagtg gatccttttt     3060

atctgtccta gacatcatta tatctagttt gttttttttt tgtaaataaa aatgtgattt     3120

tatgtgcaca gggatataat tcctaccttc tttgttttta aagaaggtat agtttttaaa     3180

gttttacaat accttgtctt tgagaattat aaaatatctc agtaacatgt gtaacattaa     3240

attgttaaca aaacatctct tggaggtttt gaaaataaaa attttgaagc                3290


<210> 64
<211> 329
<212> PRT
<213> Mus musculus

<400> 64
Met Ala Gln Arg His Leu Trp Ile Trp Phe Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Ser Glu Ala Ala Gly Lys Asp Ala Asp Pro Val Val Met Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Leu Leu Asn Ile Gln Glu Pro Lys Lys 
        35                  40                  45              


Ile Asp Asn Ile Ala Trp Thr Ser Gln Ser Ser Val Ala Phe Ile Lys 
    50                  55                  60                  


Pro Gly Val Asn Lys Ala Glu Val Thr Ile Thr Gln Gly Thr Tyr Lys 
65                  70                  75                  80  


Gly Arg Ile Glu Ile Ile Asp Gln Lys Tyr Asp Leu Val Ile Arg Asp 
                85                  90                  95      


Leu Arg Met Glu Asp Ala Gly Thr Tyr Lys Ala Asp Ile Asn Glu Glu 
            100                 105                 110         


Asn Glu Glu Thr Ile Thr Lys Ile Tyr Tyr Leu His Ile Tyr Arg Arg 
        115                 120                 125             


Leu Lys Thr Pro Lys Ile Thr Gln Ser Leu Ile Ser Ser Leu Asn Asn 
    130                 135                 140                 


Thr Cys Asn Ile Thr Leu Thr Cys Ser Val Glu Lys Glu Glu Lys Asp 
145                 150                 155                 160 


Val Thr Tyr Ser Trp Ser Pro Phe Gly Glu Lys Ser Asn Val Leu Gln 
                165                 170                 175     


Ile Val His Ser Pro Met Asp Gln Lys Leu Thr Tyr Thr Cys Thr Ala 
            180                 185                 190         


Gln Asn Pro Val Ser Asn Ser Ser Asp Ser Val Thr Val Gln Gln Pro 
        195                 200                 205             


Cys Thr Asp Thr Pro Ser Phe His Pro Arg His Ala Val Leu Pro Gly 
    210                 215                 220                 


Gly Leu Ala Val Leu Phe Leu Leu Ile Leu Ile Pro Met Leu Ala Phe 
225                 230                 235                 240 


Leu Phe Arg Leu Tyr Lys Arg Arg Arg Asp Arg Ile Val Leu Glu Ala 
                245                 250                 255     


Asp Asp Val Ser Lys Lys Thr Val Tyr Ala Val Val Ser Arg Asn Ala 
            260                 265                 270         


Gln Pro Thr Glu Ser Arg Ile Tyr Asp Glu Ile Pro Gln Ser Lys Met 
        275                 280                 285             


Leu Ser Cys Lys Lys Asp Pro Val Thr Thr Ile Tyr Ser Ser Val Gln 
    290                 295                 300                 


Leu Ser Glu Lys Met Lys Glu Thr Asn Met Lys Asp Arg Ser Leu Pro 
305                 310                 315                 320 


Lys Ala Leu Gly Asn Glu Ile Val Val 
                325                 


<210> 65
<211> 3520
<212> DNA
<213> Mus musculus

<400> 65
agtgcttgga gttcctctgt gactgaccac ttcttccttt tctgtctaat ggtgaacacc       60

tttctggacc agctctggac cagaatctga tttatgctct gctccggaaa caccacactg      120

aagtgaaagc agctaccaca ccagttattt ttcctcagaa gactggagtc tgactggaca      180

tggcccagcg ccatctgtgg atctggttcc tttgcctaca aacctggtct gaagcagcag      240

gaaaagatgc agacccggtg gtaatgaatg ggattcttgg ggagtcagtt actttcctct      300

taaatattca agaaccaaag aaaattgaca acattgcctg gacttctcaa tcatctgttg      360

cttttataaa accaggagtc aataaagctg aagttaccat aacccagggc acttataaag      420

gacgaataga aatcatagat cagaagtatg acctggtcat tagagacctg aggatggaag      480

atgcaggaac ttacaaagca gacatcaatg aagagaatga ggaaaccatc accaagatct      540

actaccttca tatctaccgt aagttatggc agcacggggc cttggattta cttttgattt      600

gaagatttat gatctaaacc acacccatat ttctgataac agagtttcct aactcttctt      660

atccttataa ttacataagc acatcagtac ttataaaggt ctaactttac ttctggcctt      720

gacagacttt agctgtaatc tgttttgcag cagaatttgt cctctgttct ttgttttcct      780

ttcctataaa atgtcaataa tcatattaat caatttgtaa gcattattat gacattctag      840

taagaaacta tatgcagagt ggtctttata aggcttctgc ttttaagata attacagaat      900

gcataggaaa atgcaaagaa ctatgaaagg atgtgttctg tgcccttctc ttgccctctc      960

ctctgttata ctagatccaa actcttagtc tcatcccccg tcttatacag accttctggg     1020

gtagcctttc ttcattgtct ctcctgattc caaagagata aaataagcag atcctggcac     1080

acacctttga ttccagcact caggaggcaa agacagaagg atctctatga gttcaaggct     1140

agcttggtct tcagagaaag ttccagaaca gccaagacta acaaaaagaa accctttctc     1200

aaaccaacct cccatcccca tcctcacccc ccaaaaacta ctagaatgaa agaaaaaaaa     1260

ataccaagac acaaaatgaa cagtgtctga ggaactctta tttctgtaag tattaatact     1320

ttcagaaatg cagaacagtg ttcaaggtca aaaacagaaa attggaactt tcttggaatg     1380

tgccagcact tacttaggaa tggaatcact tatattccta tagaatttaa tcacatatat     1440

agcaccggac agcattaatc acatatatag caccggacat cataagcaag gtagtagtga     1500

agcaccatcc caacattttc ttgtctcagt tctgcagggc agagaactgt tagccctgac     1560

tccagctttt tctacctaac agttttgtgc aggtgacatc tcgtccctgc tgagaaaatg     1620

aaatgagatt tagttttcac cactatggct gtaccaatac ctaccccaac gggtggcaca     1680

cacacacaca cacacacaca cacacacaca cacacacaca cacacacgtc tctccgaaaa     1740

taggtaaata atgatacttt tcttgtgttt cggctatttt ggaatattca gagcctactg     1800

ttgtagaata gctgggataa aatggagaca tcctgcccag gctgttattg actgtgcttt     1860

tttgttggca tctaggcatc tgggactggg atgattataa atctaggtga tgatgtttgg     1920

atttgtcttt gttgggtggg tggcttgttc cttgttttct gtttcctctc tggattttca     1980

gagagtgtgg tagctctatg ttttagtagg acattttctt tggatctgac atttatagcc     2040

actggaggtt ctcaataaaa gatgtttctg ggtattggga gctaacactt aggacctgtg     2100

ataggttagg agtatgaaag tgttcatagg agagagaaga agagtgttta gccaggatct     2160

gtttatttca tccccttgga atcagggaga cagtaaagtg aggtcaaccc acagggtctt     2220

ctctagatac tggggatgag actgggaagt tggatctaga ggaacagaag gaaacaggaa     2280

gatatacagg ctcctatctg cttctgggca ggaatgatct gggttagcag ggagtgcctg     2340

ctgaagatga gggctgggat aaaccaacaa gtggggagaa ggtgggtaga aagggaagat     2400

ctgtggaacc acaatagatg tgggattggg gatgtgcagg agtggggaca ttagaaggaa     2460

ggctgcagca ggtgttctgt tgcagagcta gggatgaagc tggagcttta gatttgtagg     2520

agaggaagcc ttctgttagc ttacatgttt cccaggcctg cttgggtggt gtgttcacaa     2580

ggaacactgg ttttggggac ttgtttactg gaatgaattg ggggaaggaa ggttggagta     2640

gaagatagag gtcctcaaag agaaaattaa taagtccaca aaatccaaac aaacagtgga     2700

aagaagtgaa taaactgtat aagacttgaa aatgaaaata aaatcaataa agaaaactaa     2760

aaccgagaga attctagaaa tgaaaatttt aagaatttga acagaaatta cagaggtaaa     2820

cttcaccaac aaaatatgag agatggaaga gagaatatta ggcattgaag atacaataga     2880

gaaaatgaat atatcagtca aagaaaatgt taaaccaaaa aaaaaaagtc ctaacaaaaa     2940

atacaaaaaa tttaggacac taagaaaaga caaaacctaa gactaataga aatataggaa     3000

ggaaaagaat tctacctcaa aggcccagaa aatatttcaa caaaatcata gaagaaaaat     3060

tttctcacct aaagaagata gatgcctata aggtatatga agcatatata acaacaaata     3120

gatttaacaa gaaaataaac tctccttggc acataacagt caaatcacaa agcatacaga     3180

acaaagaaag aatattaaaa gctacaaggg gaaaaggcca agtagtatat aaatgcagac     3240

ctagaatgat acctgatttc tcagtgaaga ctctaaaggc caatagagtc tggacaaatg     3300

tgctataaac tctaagagac cccagaggtc atccctgatt actataccca ccaaaatatc     3360

caacatccta aatggaaaaa ataggatatt ccataataaa gccaaattta aacaatatct     3420

gtctacaaat ccatctatag aagatgacag ggcggaaaat tccaaccaaa agagtttaac     3480

tataccaaat aaaaacaaaa ggaataaaca atctcaaagc                           3520


<210> 66
<211> 140
<212> PRT
<213> Mus musculus

<400> 66
Met Ala Gln Arg His Leu Trp Ile Trp Phe Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Ser Glu Ala Ala Gly Lys Asp Ala Asp Pro Val Val Met Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Leu Leu Asn Ile Gln Glu Pro Lys Lys 
        35                  40                  45              


Ile Asp Asn Ile Ala Trp Thr Ser Gln Ser Ser Val Ala Phe Ile Lys 
    50                  55                  60                  


Pro Gly Val Asn Lys Ala Glu Val Thr Ile Thr Gln Gly Thr Tyr Lys 
65                  70                  75                  80  


Gly Arg Ile Glu Ile Ile Asp Gln Lys Tyr Asp Leu Val Ile Arg Asp 
                85                  90                  95      


Leu Arg Met Glu Asp Ala Gly Thr Tyr Lys Ala Asp Ile Asn Glu Glu 
            100                 105                 110         


Asn Glu Glu Thr Ile Thr Lys Ile Tyr Tyr Leu His Ile Tyr Arg Lys 
        115                 120                 125             


Leu Trp Gln His Gly Ala Leu Asp Leu Leu Leu Ile 
    130                 135                 140 


<210> 67
<211> 3287
<212> DNA
<213> Mus musculus

<400> 67
agtgcttgga gttcctctgt gactgaccac ttcttccttt tctgtctaat ggtgaacacc       60

tttctggacc agctctggac cagaatctga tttatgctct gctccggaaa caccacactg      120

aagtgaaagc agctaccaca ccagttattt ttcctcagaa gactggagtc tgactggaca      180

tggcccagcg ccatctgtgg atctggttcc tttgcctaca aacctggtct gaagcagcag      240

gaaaagatgc agacccggtg gtaatgaatg ggattcttgg ggagtcagtt actttcctct      300

taaatattca agaaccaaag aaaattgaca acattgcctg gacttctcaa tcatctgttg      360

cttttataaa accaggagtc aataaagctg aagttaccat aacccagggc acttataaag      420

gacgaataga aatcatagat cagaagtatg acctggtcat tagagacctg aggatggaag      480

atgcaggaac ttacaaagca gacatcaatg aagagaatga ggaaaccatc accaagatct      540

actaccttca tatctaccgt cgacttaaaa caccaaaaat tacacagagt ttgatatcat      600

ctttgaacaa tacctgtaat atcacactga catgctctgt ggaaaaggaa gaaaaggatg      660

tcacatatag ctggagtccc tttggagaga aaagcaatgt ccttcaaatc gtccactccc      720

ccatggacca aaaactgacc tacacatgta cagcccagaa ccctgtcagc aacagttctg      780

actctgtcac tgtccagcag ccatgtacag acactccaag cttccatcct cgccatgctg      840

tgttgccagg aggattggcc gtgctctttc tgcttattct cattccgatg ttggcatttc      900

tgttccgttt gtataagaga aggcgagaca ggattgtcct ggaagatgat gtctcaaaga      960

aaacagtata tgctgtagtt tcaagaaatg ctcaacccac agagtccaga atctatgatg     1020

aaatccctca gtccaagatg ctgtcctgta agaaagatcc ggtgaccacc atttattcct     1080

cagtgcagct ttctgagaag atgaaggaaa ccaacatgaa ggacagaagt ctgcctaagg     1140

ctttgggtaa tgaaattgtt gtctaggtga ttctctaaga ccacgaagga cacaaggaca     1200

agtcatctat gaggattgaa tcaacggttt cagtcttttg gatataacct gggccagcca     1260

agggatttag gaatgaagca agctccgtgg gtagaggtct gatccccagt gtgtaatgtt     1320

aggggccatg tacaggattg actctcaggc ccacagatct ttacccagag aaaccctgac     1380

ctgctcccat gctgtttttc ctggggaaag gaccctaggg cactcaacct ttatgcaatc     1440

agacatgcct ctcagagact gtctaacagc ttccagacta atctctgtgc agtacttagt     1500

cttacaactc tcacgggcaa cggcttcaag ttccaatttt acgatgtgtc tagcctggga     1560

tgactgttta gtttctaatg tggcgagaat gtatgttacc atgtaggaag cacagactat     1620

ggcaatctat aaatgatttg tggcatgaga ctgatgtccg aatttagggg aaggggaatg     1680

gtcttactta ggcattttat ggaaattgag tctctctccc cgagaagagg gtgatgaagc     1740

agcatccacg tctgcctctt ctccagtaac ctgcttgtta tcgacaatgt ccagccgatg     1800

gtaatgaact gaaacaaatg cgcttgaaag agatgaatca atttgagatt taacaaatcg     1860

ggtcaatttc tgaaatgccc aaggaccgaa ggagatcaat aataggagtc ccaatagggg     1920

ccctaaaagg gagggcaaca aggttgaaag tcagggggag gttgaaaacc agttttggta     1980

gtctaccttc cccctaggcc attgtaaata cttgtgtatg ggtgtaactc agctatctat     2040

agttctaagt atccactctg gttcctcttt aggtcttaaa cttccttctt cctagttgat     2100

ggtaaattcc tgtgtaaggc agtggcctag cttttattca aagtgatagt gtaatgccag     2160

aggctattct gaatgtcact gaataggcaa cactctccct gaattctaag tccatggtct     2220

gttcaagggc tttttaggac attggaacac cagtgaaggc ttagctatgt cagaattcaa     2280

tcttaaaatg cacttataat aagataatat taaaagagag cacatggatc tatacaccag     2340

actaactcgg gaatagaata tgagtacaaa atgggcagta tgcagctgct gaactaaggc     2400

tgtggtagat accttttcaa agtttgcatt cccagatttt taaaccaagg atcgtttcct     2460

aactctaata ggcagcaaaa cgtaagcagg tctctaacaa aaacataaca gtagattcct     2520

tatctaaatt aggatctaca caattagtta attgacaaga attacaatga atataaaaag     2580

acttgccaag attggcgatc ttaactctta aaattatcta acaataagca tataggtaag     2640

gtacacaaac tttcatagct ataaggagct gacctgaaag gccaaaaaca gtgtctctga     2700

caaaagcatc ttgtacattc tctgtaccag tctttttgcc tcatgagtca gcttttttag     2760

ttgtttttat tttaagttgg caccaggttg gtactccttg ctgcagccca tggcggagat     2820

acgaagtttc tttatctgtt tgtaagtggc tgctctctga tttctcttct tttgtatact     2880

caacatagct ttctggtcac cactgtcagg gcactcacag gtcacaggtc agcctgtcac     2940

attggaagct agcatgctct tgtagcattc tgtggaaaaa acagaaacat tctccctttt     3000

ccccatatta agtatctgaa caggatcatg gcaagtgcca ataagtggat cctttttatc     3060

tgtcctagac atcattatat ctagtttgtt ttttttttgt aaataaaaat gtgattttat     3120

gtgcacaggg atataattcc taccttcttt gtttttaaag aaggtatagt ttttaaagtt     3180

ttacaatacc ttgtctttga gaattataaa atatctcagt aacatgtgta acattaaatt     3240

gttaacaaaa catctcttgg aggttttgaa aataaaaatt ttgaagc                   3287


<210> 68
<211> 328
<212> PRT
<213> Mus musculus

<400> 68
Met Ala Gln Arg His Leu Trp Ile Trp Phe Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Ser Glu Ala Ala Gly Lys Asp Ala Asp Pro Val Val Met Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Leu Leu Asn Ile Gln Glu Pro Lys Lys 
        35                  40                  45              


Ile Asp Asn Ile Ala Trp Thr Ser Gln Ser Ser Val Ala Phe Ile Lys 
    50                  55                  60                  


Pro Gly Val Asn Lys Ala Glu Val Thr Ile Thr Gln Gly Thr Tyr Lys 
65                  70                  75                  80  


Gly Arg Ile Glu Ile Ile Asp Gln Lys Tyr Asp Leu Val Ile Arg Asp 
                85                  90                  95      


Leu Arg Met Glu Asp Ala Gly Thr Tyr Lys Ala Asp Ile Asn Glu Glu 
            100                 105                 110         


Asn Glu Glu Thr Ile Thr Lys Ile Tyr Tyr Leu His Ile Tyr Arg Arg 
        115                 120                 125             


Leu Lys Thr Pro Lys Ile Thr Gln Ser Leu Ile Ser Ser Leu Asn Asn 
    130                 135                 140                 


Thr Cys Asn Ile Thr Leu Thr Cys Ser Val Glu Lys Glu Glu Lys Asp 
145                 150                 155                 160 


Val Thr Tyr Ser Trp Ser Pro Phe Gly Glu Lys Ser Asn Val Leu Gln 
                165                 170                 175     


Ile Val His Ser Pro Met Asp Gln Lys Leu Thr Tyr Thr Cys Thr Ala 
            180                 185                 190         


Gln Asn Pro Val Ser Asn Ser Ser Asp Ser Val Thr Val Gln Gln Pro 
        195                 200                 205             


Cys Thr Asp Thr Pro Ser Phe His Pro Arg His Ala Val Leu Pro Gly 
    210                 215                 220                 


Gly Leu Ala Val Leu Phe Leu Leu Ile Leu Ile Pro Met Leu Ala Phe 
225                 230                 235                 240 


Leu Phe Arg Leu Tyr Lys Arg Arg Arg Asp Arg Ile Val Leu Glu Asp 
                245                 250                 255     


Asp Val Ser Lys Lys Thr Val Tyr Ala Val Val Ser Arg Asn Ala Gln 
            260                 265                 270         


Pro Thr Glu Ser Arg Ile Tyr Asp Glu Ile Pro Gln Ser Lys Met Leu 
        275                 280                 285             


Ser Cys Lys Lys Asp Pro Val Thr Thr Ile Tyr Ser Ser Val Gln Leu 
    290                 295                 300                 


Ser Glu Lys Met Lys Glu Thr Asn Met Lys Asp Arg Ser Leu Pro Lys 
305                 310                 315                 320 


Ala Leu Gly Asn Glu Ile Val Val 
                325             


<210> 69
<211> 1062
<212> DNA
<213> Homo sapiens

<400> 69
ccttctgaaa aaagaaagcc aactttcctt tcaaatacac accccaaccc gccccggcat       60

acacagaaat ggggactgcg agcagaagca acatcgctcg ccatctgcaa accaatctca      120

ttctattttg tgtcggtgct gtgggcgcct gtactctctc tgtcacacaa ccgtggtacc      180

tagaagtgga ctacactcat gaggccgtca ccataaagtg taccttctcc gcaaccggat      240

gcccttctga gcaaccaaca tgcctgtggt ttcgctacgg tgctcaccag cctgagaacc      300

tgtgcttgga cgggtgcaaa agtgaggcag acaagttcac agtgagggag gccctcaaag      360

aaaaccaagt ttccctcact gtaaacagag tgacttcaaa tgacagtgca atttacatct      420

gtggaatagc attccccagt gtgccggaag cgagagctaa acagacagga ggagggacca      480

cactggtggt aagagaaatt aagctgctca gcaaggaact gcggagcttc ctgacagctc      540

ttgtatcact gctctctgtc tatgtgaccg gtgtgtgcgt ggccttcata ctcctctcca      600

aatcaaaatc caaccctcta agaaacaaag aaataaaaga agactcacaa aagaagaaga      660

gtgctcggcg tatttttcag gaaattgctc aagaactata ccataagaga catgtggaaa      720

caaatcagca atctgagaaa gataacaaca cttatgaaaa cagaagagta ctttccaact      780

atgaaaggcc atagaaacgt tttaattttc aatgaagtca ctgaaaatcc aactccagga      840

gctatggcag tgttaatgaa catatatcat caggtcttaa aaaaaaataa aggtaaactg      900

aaaagacaac tggctacaaa gaaggatgtc agaatgtaag gaaactataa ctaatagtca      960

ttaccaaaat actaaaaccc aacaaaatgc aactgaaaaa taccttccaa atttgccaag     1020

aaaaaaaatt ctattttaaa cttgaaaaaa aaaaaaaaaa aa                        1062


<210> 70
<211> 241
<212> PRT
<213> Homo sapiens

<400> 70
Met Gly Thr Ala Ser Arg Ser Asn Ile Ala Arg His Leu Gln Thr Asn 
1               5                   10                  15      


Leu Ile Leu Phe Cys Val Gly Ala Val Gly Ala Cys Thr Leu Ser Val 
            20                  25                  30          


Thr Gln Pro Trp Tyr Leu Glu Val Asp Tyr Thr His Glu Ala Val Thr 
        35                  40                  45              


Ile Lys Cys Thr Phe Ser Ala Thr Gly Cys Pro Ser Glu Gln Pro Thr 
    50                  55                  60                  


Cys Leu Trp Phe Arg Tyr Gly Ala His Gln Pro Glu Asn Leu Cys Leu 
65                  70                  75                  80  


Asp Gly Cys Lys Ser Glu Ala Asp Lys Phe Thr Val Arg Glu Ala Leu 
                85                  90                  95      


Lys Glu Asn Gln Val Ser Leu Thr Val Asn Arg Val Thr Ser Asn Asp 
            100                 105                 110         


Ser Ala Ile Tyr Ile Cys Gly Ile Ala Phe Pro Ser Val Pro Glu Ala 
        115                 120                 125             


Arg Ala Lys Gln Thr Gly Gly Gly Thr Thr Leu Val Val Arg Glu Ile 
    130                 135                 140                 


Lys Leu Leu Ser Lys Glu Leu Arg Ser Phe Leu Thr Ala Leu Val Ser 
145                 150                 155                 160 


Leu Leu Ser Val Tyr Val Thr Gly Val Cys Val Ala Phe Ile Leu Leu 
                165                 170                 175     


Ser Lys Ser Lys Ser Asn Pro Leu Arg Asn Lys Glu Ile Lys Glu Asp 
            180                 185                 190         


Ser Gln Lys Lys Lys Ser Ala Arg Arg Ile Phe Gln Glu Ile Ala Gln 
        195                 200                 205             


Glu Leu Tyr His Lys Arg His Val Glu Thr Asn Gln Gln Ser Glu Lys 
    210                 215                 220                 


Asp Asn Asn Thr Tyr Glu Asn Arg Arg Val Leu Ser Asn Tyr Glu Arg 
225                 230                 235                 240 


Pro 
    


<210> 71
<211> 2133
<212> DNA
<213> Mus musculus

<400> 71
ggagaaggcg gcacatgcag cagagatggg ccccgtgagt gcacgcagga gccgcctccg       60

gccagagatc agcctgatcc ttttccaagt cggtatggtg ggtgcctgca ctgtgtatgt      120

gctgcaacca ggttacctag aagtggacta cggttctgac gccgtcacca tggagtgtaa      180

cttttctaca gttggatgcc ctccagtgcc accaaagagc ttgtggtttc gctgtggtac      240

tcaccagcct gaagctctgt gcttggatgg atgcagaaat gaggcagaca agttcacagt      300

gaaagaaacc ctggacccgg accaagtctt cctcactgtt aacaggctgt ctccaaatga      360

cagtgcaatt tacatctgtg gaatagcatt tcccaatgaa ctgtcaccaa gcgctaaaca      420

cgttggaaag gggactacac tggtggtaag agaaagactt ttcagcaagg aggtgcgcag      480

tttcctgata gtgctcttag ctctgctctc tgtctacatc accggtgtgt gtgtgacctt      540

catagtcctc ttcaaatcaa aatctaacgg tccaagaagc agagaaacca aaggctcaaa      600

aaagaagagt gctcggcgta tctttcagga aattgctcaa gaattatacc ataagagata      660

tgtggaaaca agtcatctac ctgagcaaga gggcactgat gaaaacagaa aagcactccc      720

caaccctgga agagcataga tgtgcttgct ttttacttaa gccactgaca gtgcaactcc      780

agaatctacg gcaatgtgaa tggacataca gcaatcaaga caacatcaaa gagagctggg      840

gtatagctca gctggcagag tgcttgccta gtaggcacaa agccctagct ttgatcccca      900

gcaccacata aactcatcaa agtgaaacaa gcctgtattc ccaacattgt gaagtataaa      960

gagtcagaag ttcaaggtca tccctgagta taggattaac ctgaagtcag agacacatca     1020

tcttgtctca aaagcaaccg tgaccaccaa aagaaaagga caggacaagt gggaaaacag     1080

ccggcctcgc cagacggcag agcataagta gctgtcacta attgtagcta cagaatatga     1140

aaacctcaag aaaactcaac tggaggacct tttttctaat tttccaagaa tagtctaaaa     1200

agccccactt tgaagaaaaa acttcatctt aacagttttt aaaaactgtt accatgttta     1260

tgttgtcagt ctacccaaca tactagatgt gtgataggca ttaactgaga gaaggcttca     1320

agttaaacca cagatctcag ttctgagggg aaataaatac tttcctgagt tgtaaaaatg     1380

atgaaacaat tagaatcaag tgagaagggc aaaaggagta aggagaagag caatttctga     1440

gtaagagaaa ctcattgtga acagtatctt ggaacaaaag tgatttcttc tgatactgta     1500

acggagcagt gggcagtgaa cattctccag ctgaggtata ggaaacaact tgggttgtac     1560

caccaacaaa acaatactac aagagaccag aggacgacta taaacaggaa acccaaagcc     1620

tatcagaaat gcctcaggaa tgcagacaac tgactctaga tgtcagtgtg gtaccaaaga     1680

actgcagccc tagtgagctt gaaaggaggg tcggatacaa caagggcctc actatctcac     1740

taaggtgacc tgagccaggc atgctggcac acacctttaa tcctaacact aaggaggcag     1800

aggcaggtga atttctgagt tcaaggccag cctgatctat agatcgagtt ccaggacagc     1860

cagggctgtt aacagaaaaa cactgtctca gaaaaaaagg gagtgggggc ttgacatgga     1920

ttgttctttg aatataagta ccaacaagga cacactgctc actaacttga tcacaggtct     1980

agtacagttg cttctaaaca ggtactaaat ataaatggca cacactctta aacatcacac     2040

actgtgatac acacatacac acacacacac acacacacac acaggtttga aatttacata     2100

cacaaaagga ataaaataat ggcatacaca gta                                  2133


<210> 72
<211> 237
<212> PRT
<213> Mus musculus

<400> 72
Met Gly Pro Val Ser Ala Arg Arg Ser Arg Leu Arg Pro Glu Ile Ser 
1               5                   10                  15      


Leu Ile Leu Phe Gln Val Gly Met Val Gly Ala Cys Thr Val Tyr Val 
            20                  25                  30          


Leu Gln Pro Gly Tyr Leu Glu Val Asp Tyr Gly Ser Asp Ala Val Thr 
        35                  40                  45              


Met Glu Cys Asn Phe Ser Thr Val Gly Cys Pro Pro Val Pro Pro Lys 
    50                  55                  60                  


Ser Leu Trp Phe Arg Cys Gly Thr His Gln Pro Glu Ala Leu Cys Leu 
65                  70                  75                  80  


Asp Gly Cys Arg Asn Glu Ala Asp Lys Phe Thr Val Lys Glu Thr Leu 
                85                  90                  95      


Asp Pro Asp Gln Val Phe Leu Thr Val Asn Arg Leu Ser Pro Asn Asp 
            100                 105                 110         


Ser Ala Ile Tyr Ile Cys Gly Ile Ala Phe Pro Asn Glu Leu Ser Pro 
        115                 120                 125             


Ser Ala Lys His Val Gly Lys Gly Thr Thr Leu Val Val Arg Glu Arg 
    130                 135                 140                 


Leu Phe Ser Lys Glu Val Arg Ser Phe Leu Ile Val Leu Leu Ala Leu 
145                 150                 155                 160 


Leu Ser Val Tyr Ile Thr Gly Val Cys Val Thr Phe Ile Val Leu Phe 
                165                 170                 175     


Lys Ser Lys Ser Asn Gly Pro Arg Ser Arg Glu Thr Lys Gly Ser Lys 
            180                 185                 190         


Lys Lys Ser Ala Arg Arg Ile Phe Gln Glu Ile Ala Gln Glu Leu Tyr 
        195                 200                 205             


His Lys Arg Tyr Val Glu Thr Ser His Leu Pro Glu Gln Glu Gly Thr 
    210                 215                 220                 


Asp Glu Asn Arg Lys Ala Leu Pro Asn Pro Gly Arg Ala 
225                 230                 235         


<210> 73
<211> 1155
<212> DNA
<213> Homo sapiens

<400> 73
gtttggtaag ttccgttttt agccccggcc tttttctagc caggctctca actgtctcct       60

gcgttgctgg gaagttctgg aaggaagcat gtgctccaga ggttgggatt cgtgtctggc      120

tctggaattg ctactgctgc ctctgtcact cctggtgacc agcattcaag gtcacttggt      180

acatatgacc gtggtctccg gcagcaacgt gactctgaac atctctgaga gcctgcctga      240

gaactacaaa caactaacct ggttttatac tttcgaccag aagattgtag aatgggattc      300

cagaaaatct aagtactttg aatccaaatt taaaggcagg gtcagacttg atcctcagag      360

tggcgcactg tacatctcta aggtccagaa agaggacaac agcacctaca tcatgagggt      420

gttgaaaaag actgggaatg agcaagaatg gaagatcaag ctgcaagtgc ttgaccctgt      480

acccaagcct gtcatcaaaa ttgagaagat agaagacatg gatgacaact gttatctgaa      540

actgtcatgt gtgatacctg gcgagtctgt aaactacacc tggtatgggg acaaaaggcc      600

cttcccaaag gagctccaga acagtgtgct tgaaaccacc cttatgccac ataattactc      660

caggtgttat acttgccaag tcagcaattc tgtgagcagc aagaatggca cggtctgcct      720

cagtccaccc tgtaccctgg cccggtcctt tggagtagaa tggattgcaa gttggctagt      780

ggtcacggtg cccaccattc ttggcctgtt acttacctga gatgagctct tttaactcaa      840

gcgaaacttc aaggccagaa gatcttgcct gttggtgatc atgctcctca ccaggacaga      900

gactgtatag gctgaccaga agcatgctgc tgaattatca acgaggattt tcaagttaac      960

ttttaaatac tggttattat ttaattttat atccctttgt tgttttctag tacacagaga     1020

tatagagata cacatgcttt tttcccaccc aaaattgtga caacattatg tgaatgtttt     1080

attatttttt aaaataaaca tttgatataa ttgtcaatta actgaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaa                                                      1155


<210> 74
<211> 243
<212> PRT
<213> Homo sapiens

<400> 74
Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Thr Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Thr 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Thr Leu Ala Arg Ser Phe Gly Val Glu 
    210                 215                 220                 


Trp Ile Ala Ser Trp Leu Val Val Thr Val Pro Thr Ile Leu Gly Leu 
225                 230                 235                 240 


Leu Leu Thr 
            


<210> 75
<211> 1537
<212> DNA
<213> Homo sapiens

<400> 75
gtttggtaag ttccgttttt agccccggcc tttttctagc caggctctca actgtctcct       60

gcgttgctgg gaagttctgg aaggaagcat gtgctccaga ggttgggatt cgtgtctggc      120

tctggaattg ctactgctgc ctctgtcact cctggtgacc agcattcaag gtcacttggt      180

acatatgacc gtggtctccg gcagcaacgt gactctgaac atctctgaga gcctgcctga      240

gaactacaaa caactaacct ggttttatac tttcgaccag aagattgtag aatgggattc      300

cagaaaatct aagtactttg aatccaaatt taaaggcagg gtcagacttg atcctcagag      360

tggcgcactg tacatctcta aggtccagaa agaggacaac agcacctaca tcatgagggt      420

gttgaaaaag actgggaatg agcaagaatg gaagatcaag ctgcaagtgc ttgaccctgt      480

acccaagcct gtcatcaaaa ttgagaagat agaagacatg gatgacaact gttatctgaa      540

actgtcatgt gtgatacctg gcgagtctgt aaactacacc tggtatgggg acaaaaggcc      600

cttcccaaag gagctccaga acagtgtgct tgaaaccacc cttatgccac ataattactc      660

caggtgttat acttgccaag tcagcaattc tgtgagcagc aagaatggca cggtctgcct      720

cagtccaccc tgtaccctgg gtaagaagga tccctgggag ctgagggggg cacagggtaa      780

ctggagttgt tttgaacaaa gaaaggctgg gggtcctatt cagcctcctt gcacagtgtg      840

gtggtgaatc cctaaggtgt ctgggagagc tgggagacgt gggttctgcc accagctcta      900

ccaccacctc ccagccagct tacctcaact tcgtgggggc tcagtgttct cacctgcaaa      960

ggacgtttgg gagagatctc tgatactcct cttccctctc ccgctctaac aaagcatagt     1020

cctaacatct gaggccaggg tcatcataga gtagactgaa acatcagggt gagcagggag     1080

aaggaagggc aagtgggcga gcagctgtct agaggggctt cattagacag ccgaagtcag     1140

ccaaggaaag agggaccgag gtcattagac cgccaaagtc agccagggaa agagggactg     1200

aggagacggg cctgagagag gccgtcgagg aggcgtgaga gcctgagcct caggcgaagc     1260

ttctcctccc cagcctgatg ttcctagatg aacttaggaa gccagattcc cctgtctcct     1320

gggaggatcc actcatgagt gtcacacctg gctctagatc aggcctacac tggtgctagc     1380

atgggacagc taaggccatg ggttttagag tcagtcatac ctggggtcac ttctaggact     1440

gtcacttact agctaaacaa gttacttagc ttccccaagt catgttcttc ctaaataaag     1500

gacaaaataa cagttcctat aaaaaaaaaa aaaaaaa                              1537


<210> 76
<211> 252
<212> PRT
<213> Homo sapiens

<400> 76
Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Thr Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Thr 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Thr Leu Gly Lys Lys Asp Pro Trp Glu 
    210                 215                 220                 


Leu Arg Gly Ala Gln Gly Asn Trp Ser Cys Phe Glu Gln Arg Lys Ala 
225                 230                 235                 240 


Gly Gly Pro Ile Gln Pro Pro Cys Thr Val Trp Trp 
                245                 250         


<210> 77
<211> 1205
<212> DNA
<213> Mus musculus

<400> 77
atacgacttc cggttttggg ttttgcttcc tgattgaagg gcaggcgccc tgacttctct       60

tacagttgtc tccagtgttc tggggaagct tctctaagta ttatgtgctt cataaaacag      120

ggatggtgtc tggtcctgga actgctactg ctgcccttgg gaactggatt tcaaggtcat      180

tcaataccag atataaatgc caccaccggc agcaatgtaa ccctgaaaat ccataaggac      240

ccacttggac catataaacg tatcacctgg cttcatacta aaaatcagaa gattttagag      300

tacaactata atagtacaaa gacaatcttc gagtctgaat ttaaaggcag ggtttatctt      360

gaagaaaaca atggtgcact tcatatctct aatgtccgga aagaggacaa aggtacctac      420

tacatgagag tgctgcgtga aactgagaac gagttgaaga taaccctgga agtatttgat      480

cctgtgccca agccttccat agaaatcaat aagactgaag cgtcgactga ttcctgtcac      540

ctgaggctat cgtgtgaggt aaaggaccag catgttgact atacttggta tgagagctcg      600

ggacctttcc ccaaaaagag tccaggatat gtgctcgatc tcatcgtcac accacagaac      660

aagtctacat tttacacctg ccaagtcagc aatcctgtaa gcagcaagaa cgacacagtg      720

tacttcactc taccttgtga tctagccaga tcttctggag tatgttggac tgcaacttgg      780

ctagtggtca caacactcat cattcacagg atcctgttaa cctgacaaga actcttctca      840

cccaagaagg caacttggaa gcacagagtc ttgccttcat ccctagcagt gttcctagcc      900

agcgaagcaa ctctggctct attggacaaa ggaaaatgtg ttactgaacg tctgcgagag      960

tttgcatgca tgctctatga aacaagcaca ggaccttgta cagtgctcca ccactgacct     1020

gtgtgcccag tcctttacaa agatttcaaa tcaacctttt aaaaactgtg cataatatct     1080

aattttatat accctagttg tttcccaaca tatattaaag ataaatgcat tctttttacc     1140

aaaatgtgac tatattattt tcatgttttc atatctcttt ttaaaataaa ttcttttaaa     1200

aaact                                                                 1205


<210> 78
<211> 240
<212> PRT
<213> Mus musculus

<400> 78
Met Cys Phe Ile Lys Gln Gly Trp Cys Leu Val Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Gly Thr Gly Phe Gln Gly His Ser Ile Pro Asp Ile Asn 
            20                  25                  30          


Ala Thr Thr Gly Ser Asn Val Thr Leu Lys Ile His Lys Asp Pro Leu 
        35                  40                  45              


Gly Pro Tyr Lys Arg Ile Thr Trp Leu His Thr Lys Asn Gln Lys Ile 
    50                  55                  60                  


Leu Glu Tyr Asn Tyr Asn Ser Thr Lys Thr Ile Phe Glu Ser Glu Phe 
65                  70                  75                  80  


Lys Gly Arg Val Tyr Leu Glu Glu Asn Asn Gly Ala Leu His Ile Ser 
                85                  90                  95      


Asn Val Arg Lys Glu Asp Lys Gly Thr Tyr Tyr Met Arg Val Leu Arg 
            100                 105                 110         


Glu Thr Glu Asn Glu Leu Lys Ile Thr Leu Glu Val Phe Asp Pro Val 
        115                 120                 125             


Pro Lys Pro Ser Ile Glu Ile Asn Lys Thr Glu Ala Ser Thr Asp Ser 
    130                 135                 140                 


Cys His Leu Arg Leu Ser Cys Glu Val Lys Asp Gln His Val Asp Tyr 
145                 150                 155                 160 


Thr Trp Tyr Glu Ser Ser Gly Pro Phe Pro Lys Lys Ser Pro Gly Tyr 
                165                 170                 175     


Val Leu Asp Leu Ile Val Thr Pro Gln Asn Lys Ser Thr Phe Tyr Thr 
            180                 185                 190         


Cys Gln Val Ser Asn Pro Val Ser Ser Lys Asn Asp Thr Val Tyr Phe 
        195                 200                 205             


Thr Leu Pro Cys Asp Leu Ala Arg Ser Ser Gly Val Cys Trp Thr Ala 
    210                 215                 220                 


Thr Trp Leu Val Val Thr Thr Leu Ile Ile His Arg Ile Leu Leu Thr 
225                 230                 235                 240 


<210> 79
<211> 938
<212> DNA
<213> Mus musculus

<400> 79
atacgacttc cggttttggg ttttgcttcc tgattgaagg gcaggcgccc tgacttctct       60

tacagttgtc tccagtgttc tggggaagct tctctaagta ttatgtgctt cataaaacag      120

ggatggtgtc tggtcctgga actgctactg ctgcccttgg gaactggatt tcaaggtcat      180

tcaataccag atataaatgc caccaccggc agcaatgtaa ccctgaaaat ccataaggac      240

ccacttggac catataaacg tatcacctgg cttcatacta aaaatcagaa gattttagag      300

tacaactata atagtacaaa gacaatcttc gagtctgaat ttaaaggcag ggtttatctt      360

gaagaaaaca atggtgcact tcatatctct aatgtccgga aagaggacaa aggtacctac      420

tacatgagag tgctgcgtga aactgagaac gagttgaaga taaccctgga agtatttgcc      480

agatcttctg gagtatgttg gactgcaact tggctagtgg tcacaacact catcattcac      540

aggatcctgt taacctgaca agaactcttc tcacccaaga aggcaacttg gaagcacaga      600

gtcttgcctt catccctagc agtgttccta gccagcgaag caactctggc tctattggac      660

aaaggaaaat gtgttactga acgtctgcga gagtttgcat gcatgctcta tgaaacaagc      720

acaggacctt gtacagtgct ccaccactga cctgtgtgcc cagtccttta caaagatttc      780

aaatcaacct tttaaaaact gtgcataata tctaatttta tataccctag ttgtttccca      840

acatatatta aagataaatg cattcttttt accaaaatgt gactatatta ttttcatgtt      900

ttcatatctc tttttaaaat aaattctttt aaaaaact                              938


<210> 80
<211> 151
<212> PRT
<213> Mus musculus

<400> 80
Met Cys Phe Ile Lys Gln Gly Trp Cys Leu Val Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Gly Thr Gly Phe Gln Gly His Ser Ile Pro Asp Ile Asn 
            20                  25                  30          


Ala Thr Thr Gly Ser Asn Val Thr Leu Lys Ile His Lys Asp Pro Leu 
        35                  40                  45              


Gly Pro Tyr Lys Arg Ile Thr Trp Leu His Thr Lys Asn Gln Lys Ile 
    50                  55                  60                  


Leu Glu Tyr Asn Tyr Asn Ser Thr Lys Thr Ile Phe Glu Ser Glu Phe 
65                  70                  75                  80  


Lys Gly Arg Val Tyr Leu Glu Glu Asn Asn Gly Ala Leu His Ile Ser 
                85                  90                  95      


Asn Val Arg Lys Glu Asp Lys Gly Thr Tyr Tyr Met Arg Val Leu Arg 
            100                 105                 110         


Glu Thr Glu Asn Glu Leu Lys Ile Thr Leu Glu Val Phe Ala Arg Ser 
        115                 120                 125             


Ser Gly Val Cys Trp Thr Ala Thr Trp Leu Val Val Thr Thr Leu Ile 
    130                 135                 140                 


Ile His Arg Ile Leu Leu Thr 
145                 150     


<210> 81
<211> 1466
<212> DNA
<213> Homo sapiens

<400> 81
tctgctcaca caggaagccc tggaagctgc ttcctcagac atgccgctgc tgctactgct       60

gcccctgctg tgggcagggg ccctggctat ggatccaaat ttctggctgc aagtgcagga      120

gtcagtgacg gtacaggagg gtttgtgcgt cctcgtgccc tgcactttct tccatcccat      180

accctactac gacaagaact ccccagttca tggttactgg ttccgggaag gagccattat      240

atccagggac tctccagtgg ccacaaacaa gctagatcaa gaagtacagg aggagactca      300

gggcagattc cgcctccttg gggatcccag taggaacaac tgctccctga gcatcgtaga      360

cgccaggagg agggataatg gttcatactt ctttcggatg gagagaggaa gtaccaaata      420

cagttacaaa tctccccagc tctctgtgca tgtgacagac ttgacccaca ggcccaaaat      480

cctcatccct ggcactctag aacccggcca ctccaaaaac ctgacctgct ctgtgtcctg      540

ggcctgtgag cagggaacac ccccgatctt ctcctggttg tcagctgccc ccacctccct      600

gggccccagg actactcact cctcggtgct cataatcacc ccacggcccc aggaccacgg      660

caccaacctg acctgtcagg tgaagttcgc tggagctggt gtgactacgg agagaaccat      720

ccagctcaac gtcacctatg ttccacagaa cccaacaact ggtatctttc caggagatgg      780

ctcagggaaa caagagacca gagcaggagt ggttcatggg gccattggag gagctggtgt      840

tacagccctg ctcgctcttt gtctctgcct catcttcttc atagtgaaga cccacaggag      900

gaaagcagcc aggacagcag tgggcaggaa tgacacccac cctaccacag ggtcagcctc      960

cccgaaacac cagaagaagt ccaagttaca tggccccact gaaacctcaa gctgttcagg     1020

tgccgcccct actgtggaga tggatgagga gctgcattat gcttccctca actttcatgg     1080

gatgaatcct tccaaggaca cctccaccga atactcagag gtcaggaccc agtgaggaac     1140

ccacaagagc atcaggctca gctagaagat ccacatcctc tacaggtcgg ggaccaaagg     1200

ctgattcttg gagatttaac accccacagg caatgggttt atagacatta tgtgagtttc     1260

ctgctatatt aacatcatct tagactttgc aagcagagag tcgtggaatc aaatctgtgc     1320

tctttcattt gctaagtgta tgatgtcaca caagctcctt aaccttccat gtctccattt     1380

tcttctctgt gaagtaggta taagaagtcc tatctcatag ggatgctgtg agcattaaat     1440

aaaggtacac atggaaaaca ccagtc                                          1466


<210> 82
<211> 364
<212> PRT
<213> Homo sapiens

<400> 82
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210> 83
<211> 1085
<212> DNA
<213> Homo sapiens

<400> 83
tctgctcaca caggaagccc tggaagctgc ttcctcagac atgccgctgc tgctactgct       60

gcccctgctg tgggcagact tgacccacag gcccaaaatc ctcatccctg gcactctaga      120

acccggccac tccaaaaacc tgacctgctc tgtgtcctgg gcctgtgagc agggaacacc      180

cccgatcttc tcctggttgt cagctgcccc cacctccctg ggccccagga ctactcactc      240

ctcggtgctc ataatcaccc cacggcccca ggaccacggc accaacctga cctgtcaggt      300

gaagttcgct ggagctggtg tgactacgga gagaaccatc cagctcaacg tcacctatgt      360

tccacagaac ccaacaactg gtatctttcc aggagatggc tcagggaaac aagagaccag      420

agcaggagtg gttcatgggg ccattggagg agctggtgtt acagccctgc tcgctctttg      480

tctctgcctc atcttcttca tagtgaagac ccacaggagg aaagcagcca ggacagcagt      540

gggcaggaat gacacccacc ctaccacagg gtcagcctcc ccgaaacacc agaagaagtc      600

caagttacat ggccccactg aaacctcaag ctgttcaggt gccgccccta ctgtggagat      660

ggatgaggag ctgcattatg cttccctcaa ctttcatggg atgaatcctt ccaaggacac      720

ctccaccgaa tactcagagg tcaggaccca gtgaggaacc cacaagagca tcaggctcag      780

ctagaagatc cacatcctct acaggtcggg gaccaaaggc tgattcttgg agatttaaca      840

ccccacaggc aatgggttta tagacattat gtgagtttcc tgctatatta acatcatctt      900

agactttgca agcagagagt cgtggaatca aatctgtgct ctttcatttg ctaagtgtat      960

gatgtcacac aagctcctta accttccatg tctccatttt cttctctgtg aagtaggtat     1020

aagaagtcct atctcatagg gatgctgtga gcattaaata aaggtacaca tggaaaacac     1080

cagtc                                                                 1085


<210> 84
<211> 237
<212> PRT
<213> Homo sapiens

<400> 84
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          


Asn Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro 
        35                  40                  45              


Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr 
    50                  55                  60                  


Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  


Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr 
                85                  90                  95      


Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr 
            100                 105                 110         


Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala 
        115                 120                 125             


Gly Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu 
    130                 135                 140                 


Ala Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg 
145                 150                 155                 160 


Lys Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr 
                165                 170                 175     


Gly Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro 
            180                 185                 190         


Thr Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp 
        195                 200                 205             


Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser 
    210                 215                 220                 


Lys Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
225                 230                 235         


<210> 85
<211> 1108
<212> DNA
<213> Homo sapiens

<400> 85
tctgctcaca caggaagccc tggaagctgc ttcctcagac atgccgctgc tgctactgct       60

gcccctgctg tgggcagggg ccctggctat ggatccaaat ttctggctgc aagtgcagga      120

gtcagtgacg gtacaggagg gtttgtgcgt cctcgtgccc tgcactttct tccatcccat      180

accctactac gacaagaact ccccagttca tggttactgg ttccgggaag gagccattat      240

atccagggac tctccagtgg ccacaaacaa gctagatcaa gaagtacagg aggagactca      300

gggcagattc cgcctccttg gggatcccag taggaacaac tgctccctga gcatcgtaga      360

cgccaggagg agggataatg gttcatactt ctttcggatg gagagaggaa gtaccaaata      420

cagttacaaa tctccccagc tctctgtgca tgtgacagac ttgacccaca ggcccaaaat      480

cctcatccct ggcactctag aacccggcca ctccaaaaac ctgacctgct ctgtgtcctg      540

ggcctgtgag cagggaacac ccccgatctt ctcctggttg tcagctgccc ccacctccct      600

gggccccagg actactcact cctcggtgct cataatcacc ccacggcccc aggaccacgg      660

caccaacctg acctgtcagg tgaagttcgc tggagctggt gtgactacgg agagaaccat      720

ccagctcaac gtcacctatg ttccacagaa cccaacaact ggtatctttc caggagatgg      780

ctcagggaaa caagagacca gagcaggagt ggttcatggg gccattggag gagctggtgt      840

tacagccctg ctcgctcttt gtctctgcct catcttcttc atagtgaaga cccacaggag      900

gaaagcagcc aggacagcag tgggcaggaa tgacacccac cctaccacag ggtcagcctc      960

cccggtacgt tgaggccaac agatcaggag atgatggcca ttgaaaagat agtttcttgg     1020

ccgggcacag tgtttcacac ctgcaatccc agcacctttg gaggccaagg cgggcggatc     1080

acgaggtcag gagattgaga ctatcctg                                        1108


<210> 86
<211> 310
<212> PRT
<213> Homo sapiens

<400> 86
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Val Arg 
305                 310 


<210> 87
<211> 653
<212> DNA
<213> Homo sapiens

<400> 87
atgaggaact tgaggcaagt caccagcccc tgatcatttc gcctaaaaga gcaaggacta       60

gagttcctga cctccaggcc agtccctgat ccctgaccta atgttatcgc ggaatgatga      120

tatatgtatc tacgggggcc tggggctggg cgggctcctg cttctggcag tggtccttct      180

gtccgcctgc ctgtgttggc tgcatcgaag agtaaagagg ctggagagga gctggcacct      240

tctgtcctgg tcccaggccc agggctcctc agagcaggaa ctccactatg catctctgca      300

gaggctgcca gtgcccagca gtgagggacc tgacctcagg ggcagagaca agagaggcac      360

caaggaggat ccaagagctg actatgcctg cattgctgag aacaaaccca cctgagcacc      420

ccagacacct tcctcaaccc aggcgggtgg acagggtccc cctgtggtcc agccagtaaa      480

aaccatggtc cccccacttc tgtgtctcag tcctctcagt ccatctcgag cctccgttca      540

aattgatcat catcaaaact tatgtggctt tttgaccttt gaatagggaa ttttttaaat      600

tttttaaaaa ttaaaataaa aaaaacacat ggctcaccct tccacccaaa aaa             653


<210> 88
<211> 104
<212> PRT
<213> Homo sapiens

<400> 88
Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Val Lys Arg Leu Glu Arg Ser Trp His Leu Leu 
        35                  40                  45              


Ser Trp Ser Gln Ala Gln Gly Ser Ser Glu Gln Glu Leu His Tyr Ala 
    50                  55                  60                  


Ser Leu Gln Arg Leu Pro Val Pro Ser Ser Glu Gly Pro Asp Leu Arg 
65                  70                  75                  80  


Gly Arg Asp Lys Arg Gly Thr Lys Glu Asp Pro Arg Ala Asp Tyr Ala 
                85                  90                  95      


Cys Ile Ala Glu Asn Lys Pro Thr 
            100                 


<210> 89
<211> 739
<212> DNA
<213> Homo sapiens

<400> 89
acttcagccc tagcagcatc tgcctgtggg aagcagctct ccacaccagc caagggggcc       60

cccacactcc cgcgctgctc tgcggctcag ggagcagccc acctgctgga tgaggaactt      120

gaggcaagtc accagcccct gatcatttcg cctaaaagag caaggactag agttcctgac      180

ctccaggcca gtccctgatc cctgacctaa tgttatcgcg gaatgatgat atatgtatct      240

acgggggcct ggggctgggc gggctcctgc ttctggcagt ggtccttctg tccgcctgcc      300

tgtgttggct gcatcgaaga gcaccttctg tcctggtccc aggcccaggg ctcctcagag      360

caggaactcc actatgcatc tctgcagagg ctgccagtgc ccagcagtga gggacctgac      420

ctcaggggca gagacaagag aggcaccaag gaggatccaa gagctgacta tgcctgcatt      480

gctgagaaca aacccacctg agcaccccag acaccttcct caacccaggc gggtggacag      540

ggtccccctg tggtccagcc agtaaaaacc atggtccccc cacttctgtg tctcagtcct      600

ctcagtccat ctcgagcctc cgttcaaatt gatcatcatc aaaacttatg tggctttttg      660

acctttgaat agggaatttt ttaaattttt taaaaattaa aataaaaaaa acacatggct      720

cacccttcca cccaaaaaa                                                   739


<210> 90
<211> 66
<212> PRT
<213> Homo sapiens

<400> 90
Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Ala Pro Ser Val Leu Val Pro Gly Pro Gly Leu 
        35                  40                  45              


Leu Arg Ala Gly Thr Pro Leu Cys Ile Ser Ala Glu Ala Ala Ser Ala 
    50                  55                  60                  


Gln Gln 
65      


<210> 91
<211> 676
<212> DNA
<213> Homo sapiens

<400> 91
gctggggagg aacccaggct gggggagaag ttaaagccag aggaggggca ggaatgtctg       60

aggtggcaac acttctcttc agccagacag cactggccag tttggagtct gtccatcctg      120

caggccacaa gctctggatg aggaacttga ggcaagtcac cagcccctga tcatttcgcc      180

taaaagagca aggactagag ttcctgacct ccaggccagt ccctgatccc tgacctaatg      240

ttatcgcgga atgatgtaaa gaggctggag aggagctggg cccagggctc ctcagagcag      300

gaactccact atgcatctct gcagaggctg ccagtgccca gcagtgaggg acctgacctc      360

aggggcagag acaagagagg caccaaggag gatccaagag ctgactatgc ctgcattgct      420

gagaacaaac ccacctgagc accccagaca ccttcctcaa cccaggcggg tggacagggt      480

ccccctgtgg tccagccagt aaaaaccatg gtccccccac ttctgtgtct cagtcctctc      540

agtccatctc gagcctccgt tcaaattgat catcatcaaa acttatgtgg ctttttgacc      600

tttgaatagg gaatttttta aattttttaa aaattaaaat aaaaaaaaca catggctcac      660

ccttccaccc aaaaaa                                                      676


<210> 92
<211> 66
<212> PRT
<213> Homo sapiens

<400> 92
Met Leu Ser Arg Asn Asp Val Lys Arg Leu Glu Arg Ser Trp Ala Gln 
1               5                   10                  15      


Gly Ser Ser Glu Gln Glu Leu His Tyr Ala Ser Leu Gln Arg Leu Pro 
            20                  25                  30          


Val Pro Ser Ser Glu Gly Pro Asp Leu Arg Gly Arg Asp Lys Arg Gly 
        35                  40                  45              


Thr Lys Glu Asp Pro Arg Ala Asp Tyr Ala Cys Ile Ala Glu Asn Lys 
    50                  55                  60                  


Pro Thr 
65      


<210> 93
<211> 769
<212> DNA
<213> Homo sapiens

<400> 93
gctggggagg aacccaggct gggggagaag ttaaagccag aggaggggca ggaatgtctg       60

aggtggcaac acttctcttc agccagacag cactggccag tttggagtct gtccatcctg      120

caggccacaa gctctggatg aggaacttga ggcaagtcac cagcccctga tcatttcgcc      180

taaaagagca aggactagag ttcctgacct ccaggccagt ccctgatccc tgacctaatg      240

ttatcgcgga atgatgatat atgtatctac gggggcctgg ggctgggcgg gctcctgctt      300

ctggcagtgg tccttctgtc cgcctgcctg tgttggctgc atcgaagagt aaagaggctg      360

gagaggagct gggcccaggg ctcctcagag caggaactcc actatgcatc tctgcagagg      420

ctgccagtgc ccagcagtga gggacctgac ctcaggggca gagacaagag aggcaccaag      480

gaggatccaa gagctgacta tgcctgcatt gctgagaaca aacccacctg agcaccccag      540

acaccttcct caacccaggc gggtggacag ggtccccctg tggtccagcc agtaaaaacc      600

atggtccccc cacttctgtg tctcagtcct ctcagtccat ctcgagcctc cgttcaaatt      660

gatcatcatc aaaacttatg tggctttttg acctttgaat agggaatttt ttaaattttt      720

taaaaattaa aataaaaaaa acacatggct cacccttcca cccaaaaaa                  769


<210> 94
<211> 97
<212> PRT
<213> Homo sapiens

<400> 94
Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Val Lys Arg Leu Glu Arg Ser Trp Ala Gln Gly 
        35                  40                  45              


Ser Ser Glu Gln Glu Leu His Tyr Ala Ser Leu Gln Arg Leu Pro Val 
    50                  55                  60                  


Pro Ser Ser Glu Gly Pro Asp Leu Arg Gly Arg Asp Lys Arg Gly Thr 
65                  70                  75                  80  


Lys Glu Asp Pro Arg Ala Asp Tyr Ala Cys Ile Ala Glu Asn Lys Pro 
                85                  90                  95      


Thr 
    


<210> 95
<211> 609
<212> DNA
<213> Homo sapiens

<400> 95
atgaggaact tgaggcaagt caccagcccc tgatcatttc gcctaaaaga gcaaggacta       60

gagttcctga cctccaggcc agtccctgat ccctgaccta atgttatcgc ggaatgatga      120

tatatgtatc tacgggggcc tggggctggg cgggctcctg cttctggcag tggtccttct      180

gtccgcctgc ctgtgttggc tgcatcgaag aggcccaggg ctcctcagag caggaactcc      240

actatgcatc tctgcagagg ctgccagtgc ccagcagtga gggacctgac ctcaggggca      300

gagacaagag aggcaccaag gaggatccaa gagctgacta tgcctgcatt gctgagaaca      360

aacccacctg agcaccccag acaccttcct caacccaggc gggtggacag ggtccccctg      420

tggtccagcc agtaaaaacc atggtccccc cacttctgtg tctcagtcct ctcagtccat      480

ctcgagcctc cgttcaaatt gatcatcatc aaaacttatg tggctttttg acctttgaat      540

agggaatttt ttaaattttt taaaaattaa aataaaaaaa acacatggct cacccttcca      600

cccaaaaaa                                                              609


<210> 96
<211> 59
<212> PRT
<213> Homo sapiens

<400> 96
Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Gly Pro Gly Leu Leu Arg Ala Gly Thr Pro Leu 
        35                  40                  45              


Cys Ile Ser Ala Glu Ala Ala Ser Ala Gln Gln 
    50                  55                  


<210> 97
<211> 560
<212> DNA
<213> Homo sapiens

<400> 97
atgaggaact tgaggcaagt caccagcccc tgatcatttc gcctaaaaga gcaaggacta       60

gagttcctga cctccaggcc agtccctgat ccctgaccta atgttatcgc ggaatgatgt      120

aaagaggctg gagaggagct ggcaccttct gtcctggtcc caggcccagg gctcctcaga      180

gcaggaactc cactatgcat ctctgcagag gctgccagtg cccagcagtg agggacctga      240

cctcaggggc agagacaaga gaggcaccaa ggaggatcca agagctgact atgcctgcat      300

tgctgagaac aaacccacct gagcacccca gacaccttcc tcaacccagg cgggtggaca      360

gggtccccct gtggtccagc cagtaaaaac catggtcccc ccacttctgt gtctcagtcc      420

tctcagtcca tctcgagcct ccgttcaaat tgatcatcat caaaacttat gtggcttttt      480

gacctttgaa tagggaattt tttaaatttt ttaaaaatta aaataaaaaa aacacatggc      540

tcacccttcc acccaaaaaa                                                  560


<210> 98
<211> 73
<212> PRT
<213> Homo sapiens

<400> 98
Met Leu Ser Arg Asn Asp Val Lys Arg Leu Glu Arg Ser Trp His Leu 
1               5                   10                  15      


Leu Ser Trp Ser Gln Ala Gln Gly Ser Ser Glu Gln Glu Leu His Tyr 
            20                  25                  30          


Ala Ser Leu Gln Arg Leu Pro Val Pro Ser Ser Glu Gly Pro Asp Leu 
        35                  40                  45              


Arg Gly Arg Asp Lys Arg Gly Thr Lys Glu Asp Pro Arg Ala Asp Tyr 
    50                  55                  60                  


Ala Cys Ile Ala Glu Asn Lys Pro Thr 
65                  70              


<210> 99
<211> 1199
<212> DNA
<213> Homo sapiens

<400> 99
ggccaagcca aagggctctc acactaagtg aagcttctcc attctgtaag ctttccggga       60

acatccaagg caagactggc acccagcaca gcagtgactg accacatacc ccactctcca      120

ggacccatgg agtccttcag ctcaaagagc ctggcactgc aagcagagaa gaagctactg      180

agtaagatgg cgggtcgctc tgtggctcat ctcttcatag atgagacaag cagtgaggtg      240

ctagatgagc tctaccgtgt gtccaaggag tacacgcaca gccggcccca ggcccagcgc      300

gtgatcaagg acctgatcaa agtggccatc aaggtggctg tgctgcaccg caatggctcc      360

tttggcccca gtgagctggc cctggctacc cgctttcgcc agaagctgcg gcagggtgcc      420

atgacggcac ttagctttgg tgaggtagac ttcaccttcg aggctgctgt tctggctggc      480

ctgctgaccg agtgccggga tgtgctgcta gagttggtgg aacaccacct cacgcccaag      540

tcacatggcc gcatccgcca cgtgtttgat cacttctctg acccaggtct gctcacggcc      600

ctctatgggc ctgacttcac tcagcacctt ggcaagatct gtgacggact caggaagctg      660

ctagacgaag ggaagctctg agagccctga gcctagcaca ttccaccttg acaaaatggt      720

tgactgagaa aacacagata atgggcttcc taaccctgct cacctggcac taacactttt      780

caatcttcag gcttcattcc ttcccaagag tgcttttgac tctgagacca gcccaccccc      840

aaacagctag tggagaagga gcaatgctga ggggtgaggc ctctctccca ctccagcccc      900

aggacaggaa acagaactgc ctgaaaaagg tgaagtgaaa cttggatctc tatttctccc      960

ataagggact tctgaaacag ggaagccccc tcccatgtga accaaggaaa ggaggcacag     1020

cccagagaac ccctttgggg atactaaaga cagaagaggg gaaggtggcc cttagagaca     1080

gagcttggac agatgccaga ggctctgttc cagagtgcag gaagaagggg ctagggcagg     1140

ggagattctc ataggggaaa taaaactact aaaatatgaa aaaaaaaaaa aaaaaaaaa      1199


<210> 100
<211> 184
<212> PRT
<213> Homo sapiens

<400> 100
Met Glu Ser Phe Ser Ser Lys Ser Leu Ala Leu Gln Ala Glu Lys Lys 
1               5                   10                  15      


Leu Leu Ser Lys Met Ala Gly Arg Ser Val Ala His Leu Phe Ile Asp 
            20                  25                  30          


Glu Thr Ser Ser Glu Val Leu Asp Glu Leu Tyr Arg Val Ser Lys Glu 
        35                  40                  45              


Tyr Thr His Ser Arg Pro Gln Ala Gln Arg Val Ile Lys Asp Leu Ile 
    50                  55                  60                  


Lys Val Ala Ile Lys Val Ala Val Leu His Arg Asn Gly Ser Phe Gly 
65                  70                  75                  80  


Pro Ser Glu Leu Ala Leu Ala Thr Arg Phe Arg Gln Lys Leu Arg Gln 
                85                  90                  95      


Gly Ala Met Thr Ala Leu Ser Phe Gly Glu Val Asp Phe Thr Phe Glu 
            100                 105                 110         


Ala Ala Val Leu Ala Gly Leu Leu Thr Glu Cys Arg Asp Val Leu Leu 
        115                 120                 125             


Glu Leu Val Glu His His Leu Thr Pro Lys Ser His Gly Arg Ile Arg 
    130                 135                 140                 


His Val Phe Asp His Phe Ser Asp Pro Gly Leu Leu Thr Ala Leu Tyr 
145                 150                 155                 160 


Gly Pro Asp Phe Thr Gln His Leu Gly Lys Ile Cys Asp Gly Leu Arg 
                165                 170                 175     


Lys Leu Leu Asp Glu Gly Lys Leu 
            180                 


<210> 101
<211> 1122
<212> DNA
<213> Mus musculus

<400> 101
gctctcagaa acatccaagg ccagactggc acccagcaca cggcagccgg ttgcctcttc       60

cagtgactga tcacacaccg accgcaagca ccatggagtc cttcagctca aagagtctgg      120

cactacaagc ggagaagaag ctgctgagta aaatggctgg tcggtccgtg gcgcatctct      180

ttatcgacga gaccagcagc gaggtgctag acgagcttta ccgcgtgtcc aaagaataca      240

cgcacagccg gcccaaggca cagcgggtga tcaaagacct catcaaggta gcggttaaag      300

tggctgtgct gcaccgcagt ggctgctttg gccctgggga gctggctctg gctacacgat      360

ttcgtcagaa gctacggcag ggcgccatga ccgcacttag cttcggtgag gtggacttca      420

cctttgaggc tgccgtgcta gcaggtctgc tcgtcgagtg ccgggacatt ctgctggagc      480

tggtggagca ccacctcaca cccaagtcac atgaccgcat caggcacgtg tttgatcact      540

actctgaccc cgacctgctg gctgccctct atgggcctga cttcactcag caccttggca      600

agatctgtga tgggctccgg aagctgctgg acgagggcaa gctctgaagc tccggagctc      660

agcacactgg actttggcaa aatgactgac tgggaaatga cacatcgggc tctctaaccc      720

tgcaccaatg cttctcgatc ccctggcttc actctctccc aagagtgcta tagacactga      780

ggccaccccc acccccaaac tactgctggg gcaaagcaag gctgaactga gtgaggcggc      840

tctcgctccc atccagttcc agtaaaggaa acagctgact gaagaagaag tgaaactcag      900

gtccgcttct cccgggaggg ctgcccagaa ccgggggatc ctcctcctcc acaaacccga      960

ggaaggggac actaaaggcc acacgcagga aggtggtcat tagagacctc ctggatctag     1020

agttggaggc agcactagga cacatacaga cgctgtgttc cagagcttct agaaggagct     1080

gggggaaggg aggcacaggg gaaataaaac cactaaagca tg                        1122


<210> 102
<211> 184
<212> PRT
<213> Mus musculus

<400> 102
Met Glu Ser Phe Ser Ser Lys Ser Leu Ala Leu Gln Ala Glu Lys Lys 
1               5                   10                  15      


Leu Leu Ser Lys Met Ala Gly Arg Ser Val Ala His Leu Phe Ile Asp 
            20                  25                  30          


Glu Thr Ser Ser Glu Val Leu Asp Glu Leu Tyr Arg Val Ser Lys Glu 
        35                  40                  45              


Tyr Thr His Ser Arg Pro Lys Ala Gln Arg Val Ile Lys Asp Leu Ile 
    50                  55                  60                  


Lys Val Ala Val Lys Val Ala Val Leu His Arg Ser Gly Cys Phe Gly 
65                  70                  75                  80  


Pro Gly Glu Leu Ala Leu Ala Thr Arg Phe Arg Gln Lys Leu Arg Gln 
                85                  90                  95      


Gly Ala Met Thr Ala Leu Ser Phe Gly Glu Val Asp Phe Thr Phe Glu 
            100                 105                 110         


Ala Ala Val Leu Ala Gly Leu Leu Val Glu Cys Arg Asp Ile Leu Leu 
        115                 120                 125             


Glu Leu Val Glu His His Leu Thr Pro Lys Ser His Asp Arg Ile Arg 
    130                 135                 140                 


His Val Phe Asp His Tyr Ser Asp Pro Asp Leu Leu Ala Ala Leu Tyr 
145                 150                 155                 160 


Gly Pro Asp Phe Thr Gln His Leu Gly Lys Ile Cys Asp Gly Leu Arg 
                165                 170                 175     


Lys Leu Leu Asp Glu Gly Lys Leu 
            180                 


<210> 103
<211> 1426
<212> DNA
<213> Homo sapiens

<400> 103
gactatctcc cagcggcagg cccttcgata aaatcaggaa cttgtgctgg ccctgcaatg       60

tcaagggagg gggctcaccc agggctcctg tagctcaggg ggcaggcctg agccctgcac      120

ccgccccacg accgtccagc ccctgacggg gcaccccatc ctgaggggct ctgcattggc      180

ccccaccgag gcaggggatc tgaccgactc ggagcccggc tggatgttac aggcgtgcaa      240

aatggaaggg tttcccctcg tcccccctca gccatcagaa gacctggtgc cctatgacac      300

ggatctatac caacgccaaa cgcacgagta ttacccctat ctcagcagtg atggggagag      360

ccatagcgac cattactggg acttccaccc ccaccacgtg cacagcgagt tcgagagctt      420

cgccgagaac aacttcacgg agctccagag cgtgcagccc ccgcagctgc agcagctcta      480

ccgccacatg gagctggagc agatgcacgt cctcgatacc cccatggtgc caccccatcc      540

cagtcttggc caccaggtct cctacctgcc ccggatgtgc ctccagtacc catccctgtc      600

cccagcccag cccagctcag atgaggagga gggcgagcgg cagagccccc cactggaggt      660

gtctgacggc gaggcggatg gcctggagcc cgggcctggg ctcctgcctg gggagacagg      720

cagcaagaag aagatccgcc tgtaccagtt cctgttggac ctgctccgca gcggcgacat      780

gaaggacagc atctggtggg tggacaagga caagggcacc ttccagttct cgtccaagca      840

caaggaggcg ctggcgcacc gctggggcat ccagaagggc aaccgcaaga agatgaccta      900

ccagaagatg gcgcgcgcgc tgcgcaacta cggcaagacg ggcgaggtca agaaggtgaa      960

gaagaagctc acctaccagt tcagcggcga agtgctgggc cgcgggggcc tggccgagcg     1020

gcgccacccg ccccactgag cccgcagccc ccgccgggcc ccgccaggcc tccccgctgg     1080

ccatagcatt aagccctcgc ccggcccgga cacagggagg acgctcccgg ggcccagagg     1140

caggactgtg gcgggccggg cctcgcctca cccgccccct ccccccactc caggccccct     1200

ccacatcccg cttcgcctcc ctccaggact ccaccccggc tcccggacgc cagctgggcg     1260

tcagacccca ccggggcaac cttgcagagg acgacccggg gtactgcctt gggagtctca     1320

agtccgtatg taaatcagat ctcccctctc acccctccca cccattaacc tcctcccaaa     1380

aaacaagtaa agttattctc aatccatcaa aaaaaaaaaa aaaaaa                    1426


<210> 104
<211> 271
<212> PRT
<213> Homo sapiens

<400> 104
Met Leu Gln Ala Cys Lys Met Glu Gly Phe Pro Leu Val Pro Pro Gln 
1               5                   10                  15      


Pro Ser Glu Asp Leu Val Pro Tyr Asp Thr Asp Leu Tyr Gln Arg Gln 
            20                  25                  30          


Thr His Glu Tyr Tyr Pro Tyr Leu Ser Ser Asp Gly Glu Ser His Ser 
        35                  40                  45              


Asp His Tyr Trp Asp Phe His Pro His His Val His Ser Glu Phe Glu 
    50                  55                  60                  


Ser Phe Ala Glu Asn Asn Phe Thr Glu Leu Gln Ser Val Gln Pro Pro 
65                  70                  75                  80  


Gln Leu Gln Gln Leu Tyr Arg His Met Glu Leu Glu Gln Met His Val 
                85                  90                  95      


Leu Asp Thr Pro Met Val Pro Pro His Pro Ser Leu Gly His Gln Val 
            100                 105                 110         


Ser Tyr Leu Pro Arg Met Cys Leu Gln Tyr Pro Ser Leu Ser Pro Ala 
        115                 120                 125             


Gln Pro Ser Ser Asp Glu Glu Glu Gly Glu Arg Gln Ser Pro Pro Leu 
    130                 135                 140                 


Glu Val Ser Asp Gly Glu Ala Asp Gly Leu Glu Pro Gly Pro Gly Leu 
145                 150                 155                 160 


Leu Pro Gly Glu Thr Gly Ser Lys Lys Lys Ile Arg Leu Tyr Gln Phe 
                165                 170                 175     


Leu Leu Asp Leu Leu Arg Ser Gly Asp Met Lys Asp Ser Ile Trp Trp 
            180                 185                 190         


Val Asp Lys Asp Lys Gly Thr Phe Gln Phe Ser Ser Lys His Lys Glu 
        195                 200                 205             


Ala Leu Ala His Arg Trp Gly Ile Gln Lys Gly Asn Arg Lys Lys Met 
    210                 215                 220                 


Thr Tyr Gln Lys Met Ala Arg Ala Leu Arg Asn Tyr Gly Lys Thr Gly 
225                 230                 235                 240 


Glu Val Lys Lys Val Lys Lys Lys Leu Thr Tyr Gln Phe Ser Gly Glu 
                245                 250                 255     


Val Leu Gly Arg Gly Gly Leu Ala Glu Arg Arg His Pro Pro His 
            260                 265                 270     


<210> 105
<211> 1423
<212> DNA
<213> Homo sapiens

<400> 105
gactatctcc cagcggcagg cccttcgata aaatcaggaa cttgtgctgg ccctgcaatg       60

tcaagggagg gggctcaccc agggctcctg tagctcaggg ggcaggcctg agccctgcac      120

ccgccccacg accgtccagc ccctgacggg gcaccccatc ctgaggggct ctgcattggc      180

ccccaccgag gcaggggatc tgaccgactc ggagcccggc tggatgttac aggcgtgcaa      240

aatggaaggg tttcccctcg tcccccctcc atcagaagac ctggtgccct atgacacgga      300

tctataccaa cgccaaacgc acgagtatta cccctatctc agcagtgatg gggagagcca      360

tagcgaccat tactgggact tccaccccca ccacgtgcac agcgagttcg agagcttcgc      420

cgagaacaac ttcacggagc tccagagcgt gcagcccccg cagctgcagc agctctaccg      480

ccacatggag ctggagcaga tgcacgtcct cgataccccc atggtgccac cccatcccag      540

tcttggccac caggtctcct acctgccccg gatgtgcctc cagtacccat ccctgtcccc      600

agcccagccc agctcagatg aggaggaggg cgagcggcag agccccccac tggaggtgtc      660

tgacggcgag gcggatggcc tggagcccgg gcctgggctc ctgcctgggg agacaggcag      720

caagaagaag atccgcctgt accagttcct gttggacctg ctccgcagcg gcgacatgaa      780

ggacagcatc tggtgggtgg acaaggacaa gggcaccttc cagttctcgt ccaagcacaa      840

ggaggcgctg gcgcaccgct ggggcatcca gaagggcaac cgcaagaaga tgacctacca      900

gaagatggcg cgcgcgctgc gcaactacgg caagacgggc gaggtcaaga aggtgaagaa      960

gaagctcacc taccagttca gcggcgaagt gctgggccgc gggggcctgg ccgagcggcg     1020

ccacccgccc cactgagccc gcagcccccg ccgggccccg ccaggcctcc ccgctggcca     1080

tagcattaag ccctcgcccg gcccggacac agggaggacg ctcccggggc ccagaggcag     1140

gactgtggcg ggccgggcct cgcctcaccc gccccctccc cccactccag gccccctcca     1200

catcccgctt cgcctccctc caggactcca ccccggctcc cggacgccag ctgggcgtca     1260

gaccccaccg gggcaacctt gcagaggacg acccggggta ctgccttggg agtctcaagt     1320

ccgtatgtaa atcagatctc ccctctcacc cctcccaccc attaacctcc tcccaaaaaa     1380

caagtaaagt tattctcaat ccatcaaaaa aaaaaaaaaa aaa                       1423


<210> 106
<211> 270
<212> PRT
<213> Homo sapiens

<400> 106
Met Leu Gln Ala Cys Lys Met Glu Gly Phe Pro Leu Val Pro Pro Pro 
1               5                   10                  15      


Ser Glu Asp Leu Val Pro Tyr Asp Thr Asp Leu Tyr Gln Arg Gln Thr 
            20                  25                  30          


His Glu Tyr Tyr Pro Tyr Leu Ser Ser Asp Gly Glu Ser His Ser Asp 
        35                  40                  45              


His Tyr Trp Asp Phe His Pro His His Val His Ser Glu Phe Glu Ser 
    50                  55                  60                  


Phe Ala Glu Asn Asn Phe Thr Glu Leu Gln Ser Val Gln Pro Pro Gln 
65                  70                  75                  80  


Leu Gln Gln Leu Tyr Arg His Met Glu Leu Glu Gln Met His Val Leu 
                85                  90                  95      


Asp Thr Pro Met Val Pro Pro His Pro Ser Leu Gly His Gln Val Ser 
            100                 105                 110         


Tyr Leu Pro Arg Met Cys Leu Gln Tyr Pro Ser Leu Ser Pro Ala Gln 
        115                 120                 125             


Pro Ser Ser Asp Glu Glu Glu Gly Glu Arg Gln Ser Pro Pro Leu Glu 
    130                 135                 140                 


Val Ser Asp Gly Glu Ala Asp Gly Leu Glu Pro Gly Pro Gly Leu Leu 
145                 150                 155                 160 


Pro Gly Glu Thr Gly Ser Lys Lys Lys Ile Arg Leu Tyr Gln Phe Leu 
                165                 170                 175     


Leu Asp Leu Leu Arg Ser Gly Asp Met Lys Asp Ser Ile Trp Trp Val 
            180                 185                 190         


Asp Lys Asp Lys Gly Thr Phe Gln Phe Ser Ser Lys His Lys Glu Ala 
        195                 200                 205             


Leu Ala His Arg Trp Gly Ile Gln Lys Gly Asn Arg Lys Lys Met Thr 
    210                 215                 220                 


Tyr Gln Lys Met Ala Arg Ala Leu Arg Asn Tyr Gly Lys Thr Gly Glu 
225                 230                 235                 240 


Val Lys Lys Val Lys Lys Lys Leu Thr Tyr Gln Phe Ser Gly Glu Val 
                245                 250                 255     


Leu Gly Arg Gly Gly Leu Ala Glu Arg Arg His Pro Pro His 
            260                 265                 270 


<210> 107
<211> 1473
<212> DNA
<213> Mus musculus

<400> 107
aagagattta tgcaaacggg ctggggcggt gatgtcaccc caaggggact atctcccagt       60

ggcaggccct tcgataaaat caggaacttg tgctggccct gcaatgtcaa gggagggggc      120

tcacccaggg ctcctgtagc tcagggggca ggcctgagcc ctgcgtctga cccacgaccg      180

tccagtcccc cgacggggca cctggtcctg agggggatcc gccttgatcc ccaccgaagc      240

aggggatctg accaacctgg agctcagctg gatgttacag gcgtgcaaaa tggaagggtt      300

ttccctcacc gcccctccat cggatgactt ggttacttac gattcagagc tataccaacg      360

tccaatgcat gactactact ccttcgtggg cagcgatgga gaaagccata gcgatcacta      420

ctgggatttc tccgcacacc atgtccacaa caacgagttt gagaacttcc ctgagaacca      480

cttcacagag ctgcagagtg tgcagccccc gcagctacag cagctctatc gccacatgga      540

gctggaacag atgcacgtcc tcgatactcc catggtgcca ccccacaccg gcctcagtca      600

ccaggtttcc tacatgcccc ggatgtgctt cccttatcaa accttgtccc cagcccacca      660

gcagagctca gatgaggagg agggtgagag gcagagccct cccctggagg tgtctgatgg      720

agaagctgat ggcttggagc ctgggccagg tcttctgcac ggggagacag gcagcaagaa      780

aaagattcgc ctgtaccagt tcctgctgga cctgctgcgc agcggcgaca tgaaggacag      840

catctggtgg gtggacaagg acaaaggtac cttccagttc tcgtccaagc acaaggaggc      900

gctggcgcac cgctggggca tccagaaggg caaccgcaag aagatgacct accagaagat      960

ggcgcgcgcg ctgcgcaact acggcaagac aggcgaggtg aagaaagtca agaagaagct     1020

cacctaccag ttcagcggcg aggtgctggg ccgtgggggc ctggccgagc ggcgcctccc     1080

gccccactga tcgcccgcag agaccgccag gctcctggac cccgccggcc atagcattaa     1140

cccgtcgccc ggcccggaca cagggaggac attcccaggg ccgaggcagg actgggggcc     1200

cggcctcgcc ctcccatgcc cggcctggcc cgccccaccc gctttgcctc ccaccaggac     1260

tctagcccgc tccaagggcc gcctgggcct cggacctcaa ccgagggtca gcctggctta     1320

gtggccacgg tgcttccttg ggagtctggc gctggcacct ttttgtatat tgaatgcttt     1380

ttaaaaagct cttcctcccc accccctcat tagtcactaa agacaagtaa aattattgac     1440

agctattctc ccagaaaaaa aaaaaaaaaa aaa                                  1473


<210> 108
<211> 272
<212> PRT
<213> Mus musculus

<400> 108
Met Leu Gln Ala Cys Lys Met Glu Gly Phe Ser Leu Thr Ala Pro Pro 
1               5                   10                  15      


Ser Asp Asp Leu Val Thr Tyr Asp Ser Glu Leu Tyr Gln Arg Pro Met 
            20                  25                  30          


His Asp Tyr Tyr Ser Phe Val Gly Ser Asp Gly Glu Ser His Ser Asp 
        35                  40                  45              


His Tyr Trp Asp Phe Ser Ala His His Val His Asn Asn Glu Phe Glu 
    50                  55                  60                  


Asn Phe Pro Glu Asn His Phe Thr Glu Leu Gln Ser Val Gln Pro Pro 
65                  70                  75                  80  


Gln Leu Gln Gln Leu Tyr Arg His Met Glu Leu Glu Gln Met His Val 
                85                  90                  95      


Leu Asp Thr Pro Met Val Pro Pro His Thr Gly Leu Ser His Gln Val 
            100                 105                 110         


Ser Tyr Met Pro Arg Met Cys Phe Pro Tyr Gln Thr Leu Ser Pro Ala 
        115                 120                 125             


His Gln Gln Ser Ser Asp Glu Glu Glu Gly Glu Arg Gln Ser Pro Pro 
    130                 135                 140                 


Leu Glu Val Ser Asp Gly Glu Ala Asp Gly Leu Glu Pro Gly Pro Gly 
145                 150                 155                 160 


Leu Leu His Gly Glu Thr Gly Ser Lys Lys Lys Ile Arg Leu Tyr Gln 
                165                 170                 175     


Phe Leu Leu Asp Leu Leu Arg Ser Gly Asp Met Lys Asp Ser Ile Trp 
            180                 185                 190         


Trp Val Asp Lys Asp Lys Gly Thr Phe Gln Phe Ser Ser Lys His Lys 
        195                 200                 205             


Glu Ala Leu Ala His Arg Trp Gly Ile Gln Lys Gly Asn Arg Lys Lys 
    210                 215                 220                 


Met Thr Tyr Gln Lys Met Ala Arg Ala Leu Arg Asn Tyr Gly Lys Thr 
225                 230                 235                 240 


Gly Glu Val Lys Lys Val Lys Lys Lys Leu Thr Tyr Gln Phe Ser Gly 
                245                 250                 255     


Glu Val Leu Gly Arg Gly Gly Leu Ala Glu Arg Arg Leu Pro Pro His 
            260                 265                 270         


<210> 109
<211> 2940
<212> DNA
<213> Homo sapiens

<400> 109
atttggttga aagaaaaccc acaatccagt gtcaagaaag aagtcaactt ttcttcccct       60

acttccctgc atttctcctc tgtgctcact gccacacaca gctcaacctg gacagcacag      120

ccagaggcga gatgcttctc tgctgatctg agtctgcctg cagcatggac ctgggtcttc      180

cctgaagcat ctccagggct ggagggacga ctgccatgca ccgagggctc atccatccgc      240

agagcagggc agtgggagga gacgccatga cccccatcgt cacagtcctg atctgtctcg      300

ggctgagtct gggccccagg acccgcgtgc agacagggac catccccaag cccaccctgt      360

gggctgagcc agactctgtg atcacccagg ggagtcccgt caccctcagt tgtcagggga      420

gccttgaagc ccaggagtac cgtctatata gggagaaaaa atcagcatct tggattacac      480

ggatacgacc agagcttgtg aagaacggcc agttccacat cccatccatc acctgggaac      540

acacagggcg atatggctgt cagtattaca gccgcgctcg gtggtctgag ctcagtgacc      600

ccctggtgct ggtgatgaca ggagcctacc caaaacccac cctctcagcc cagcccagcc      660

ctgtggtgac ctcaggagga agggtgaccc tccagtgtga gtcacaggtg gcatttggcg      720

gcttcattct gtgtaaggaa ggagaagatg aacacccaca atgcctgaac tcccagcccc      780

atgcccgtgg gtcgtcccgc gccatcttct ccgtgggccc cgtgagcccg aatcgcaggt      840

ggtcgcacag gtgctatggt tatgacttga actctcccta tgtgtggtct tcacccagtg      900

atctcctgga gctcctggtc ccaggtgttt ctaagaagcc atcactctca gtgcagccgg      960

gtcctgtcat ggcccctggg gaaagcctga ccctccagtg tgtctctgat gtcggctatg     1020

acagatttgt tctgtacaag gagggggaac gtgaccttcg ccagctccct ggccggcagc     1080

cccaggctgg gctctcccag gccaacttca ccctgggccc tgtgagccgc tcctacgggg     1140

gccagtacag atgctacggt gcacacaacc tctcctctga gtgctcggcc cccagcgacc     1200

ccctggacat cctgatcaca ggacagatcc gtggcacacc cttcatctca gtgcagccag     1260

gccccacagt ggcctcagga gagaacgtga ccctgctgtg tcagtcatgg cggcagttcc     1320

acactttcct tctgaccaag gcgggagcag ctgatgcccc actccgtcta agatcaatac     1380

acgaatatcc taagtaccag gctgaattcc ccatgagtcc tgtgacctca gcccacgcgg     1440

ggacctacag gtgctacggc tcactcaact ccgaccccta cctgctgtct caccccagtg     1500

agcccctgga gctcgtggtc tcaggaccct ccatgggttc cagcccccca cccaccggtc     1560

ccatctccac acctgcaggc cctgaggacc agcccctcac ccccactggg tcggatcccc     1620

aaagtggtct gggaaggcac ctgggggttg tgatcggcat cttggtggcc gtcgtcctac     1680

tgctcctcct cctcctcctc ctcttcctca tcctccgaca tcgacgtcag ggcaaacact     1740

ggacatcgac ccagagaaag gctgatttcc aacatcctgc aggggctgtg gggccagagc     1800

ccacagacag aggcctgcag tggaggtcca gcccagctgc cgacgcccag gaagaaaacc     1860

tctatgctgc cgtgaaggac acacagcctg aagatggggt ggagatggac actcgggctg     1920

ctgcatctga agccccccag gatgtgacct acgcccagct gcacagcttg accctcagac     1980

ggaaggcaac tgagcctcct ccatcccagg aaagggaacc tccagctgag cccagcatct     2040

acgccaccct ggccatccac tagcccggag ggtacgcaga ctccacactc agtagaagga     2100

gactcaggac tgctgaaggc acgggagctg cccccagtgg acaccaatga accccagtca     2160

gcctggaccc ctaacaaaga ccatgaggag atgctgggaa ctttgggact cacttgattc     2220

tgcagtcgaa ataactaata tccctacatt ttttaattaa agcaacagac ttctcaataa     2280

tcaatgagtt aaccgagaaa actaaaatca gaagtaagaa tgtgctttaa actgaatcac     2340

aatataaata ttacacatca cacaatgaaa ttgaaaaagt acaaaccaca aatgaaaaaa     2400

gtagaaacga aaaaaaaaaa ctaggaaatg aatgacgttg gctttcgtat aaggaattta     2460

gaaaaagaat aaccaattat tccaaatgaa ggtgtaagaa agggaataag aagaagaaga     2520

gttgctcatg aggaaaaacc aaaacttgaa aattcaacaa agccaatgaa gctcattctt     2580

gaaaatatta attacagtca taaatcctaa ctacattgag caagagaaag aaagagcagg     2640

cacgcatttc catatgggag tgagccagca gacagcccag cagatcctac acacattttc     2700

acaaactaac cccagaacag gctgcaaacc tataccaata tactagaaaa tgcagattaa     2760

atggatgaaa tattcaaaac tggagtttac ataatgaacg taagagtaat cagagaatct     2820

gactcatttt aaatgtgtgt gtatgtgtgt gtatatatat gtgtgtgtgt gtgtgtgtgt     2880

gtgtgtgtga aaaacattga ctgtaataaa aatgttccca tcgtaaaaaa aaaaaaaaaa     2940


<210> 110
<211> 598
<212> PRT
<213> Homo sapiens

<400> 110
Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Val Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn 
65                  70                  75                  80  


Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro 
            100                 105                 110         


Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys 
    130                 135                 140                 


Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu 
145                 150                 155                 160 


Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser 
                165                 170                 175     


Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp 
            180                 185                 190         


Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser 
        195                 200                 205             


Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys 
    210                 215                 220                 


Pro Ser Leu Ser Val Gln Pro Gly Pro Val Met Ala Pro Gly Glu Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Cys Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Arg Gly Thr Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu 
385                 390                 395                 400 


Asn Ser Asp Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Val Val Ser Gly Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro 
            420                 425                 430         


Ile Ser Thr Pro Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val 
545                 550                 555                 560 


Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu 
                565                 570                 575     


Pro Pro Pro Ser Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr 
            580                 585                 590         


Ala Thr Leu Ala Ile His 
        595             


<210> 111
<211> 2937
<212> DNA
<213> Homo sapiens

<400> 111
atttggttga aagaaaaccc acaatccagt gtcaagaaag aagtcaactt ttcttcccct       60

acttccctgc atttctcctc tgtgctcact gccacacaca gctcaacctg gacagcacag      120

ccagaggcga gatgcttctc tgctgatctg agtctgcctg cagcatggac ctgggtcttc      180

cctgaagcat ctccagggct ggagggacga ctgccatgca ccgagggctc atccatccgc      240

agagcagggc agtgggagga gacgccatga cccccatcgt cacagtcctg atctgtctcg      300

ggctgagtct gggccccagg acccgcgtgc agacagggac catccccaag cccaccctgt      360

gggctgagcc agactctgtg atcacccagg ggagtcccgt caccctcagt tgtcagggga      420

gccttgaagc ccaggagtac cgtctatata gggagaaaaa atcagcatct tggattacac      480

ggatacgacc agagcttgtg aagaacggcc agttccacat cccatccatc acctgggaac      540

acacagggcg atatggctgt cagtattaca gccgcgctcg gtggtctgag ctcagtgacc      600

ccctggtgct ggtgatgaca ggagcctacc caaaacccac cctctcagcc cagcccagcc      660

ctgtggtgac ctcaggagga agggtgaccc tccagtgtga gtcacaggtg gcatttggcg      720

gcttcattct gtgtaaggaa ggagaagatg aacacccaca atgcctgaac tcccagcccc      780

atgcccgtgg gtcgtcccgc gccatcttct ccgtgggccc cgtgagcccg aatcgcaggt      840

ggtcgcacag gtgctatggt tatgacttga actctcccta tgtgtggtct tcacccagtg      900

atctcctgga gctcctggtc ccaggtgttt ctaagaagcc atcactctca gtgcagccgg      960

gtcctgtcat ggcccctggg gaaagcctga ccctccagtg tgtctctgat gtcggctatg     1020

acagatttgt tctgtacaag gagggggaac gtgaccttcg ccagctccct ggccggcagc     1080

cccaggctgg gctctcccag gccaacttca ccctgggccc tgtgagccgc tcctacgggg     1140

gccagtacag atgctacggt gcacacaacc tctcctctga gtgctcggcc cccagcgacc     1200

ccctggacat cctgatcaca ggacagatcc gtggcacacc cttcatctca gtgcagccag     1260

gccccacagt ggcctcagga gagaacgtga ccctgctgtg tcagtcatgg cggcagttcc     1320

acactttcct tctgaccaag gcgggagcag ctgatgcccc actccgtcta agatcaatac     1380

acgaatatcc taagtaccag gctgaattcc ccatgagtcc tgtgacctca gcccacgcgg     1440

ggacctacag gtgctacggc tcactcaact ccgaccccta cctgctgtct caccccagtg     1500

agcccctgga gctcgtggtc tcaggaccct ccatgggttc cagcccccca cccaccggtc     1560

ccatctccac acctggccct gaggaccagc ccctcacccc cactgggtcg gatccccaaa     1620

gtggtctggg aaggcacctg ggggttgtga tcggcatctt ggtggccgtc gtcctactgc     1680

tcctcctcct cctcctcctc ttcctcatcc tccgacatcg acgtcagggc aaacactgga     1740

catcgaccca gagaaaggct gatttccaac atcctgcagg ggctgtgggg ccagagccca     1800

cagacagagg cctgcagtgg aggtccagcc cagctgccga cgcccaggaa gaaaacctct     1860

atgctgccgt gaaggacaca cagcctgaag atggggtgga gatggacact cgggctgctg     1920

catctgaagc cccccaggat gtgacctacg cccagctgca cagcttgacc ctcagacgga     1980

aggcaactga gcctcctcca tcccaggaaa gggaacctcc agctgagccc agcatctacg     2040

ccaccctggc catccactag cccggagggt acgcagactc cacactcagt agaaggagac     2100

tcaggactgc tgaaggcacg ggagctgccc ccagtggaca ccaatgaacc ccagtcagcc     2160

tggaccccta acaaagacca tgaggagatg ctgggaactt tgggactcac ttgattctgc     2220

agtcgaaata actaatatcc ctacattttt taattaaagc aacagacttc tcaataatca     2280

atgagttaac cgagaaaact aaaatcagaa gtaagaatgt gctttaaact gaatcacaat     2340

ataaatatta cacatcacac aatgaaattg aaaaagtaca aaccacaaat gaaaaaagta     2400

gaaacgaaaa aaaaaaacta ggaaatgaat gacgttggct ttcgtataag gaatttagaa     2460

aaagaataac caattattcc aaatgaaggt gtaagaaagg gaataagaag aagaagagtt     2520

gctcatgagg aaaaaccaaa acttgaaaat tcaacaaagc caatgaagct cattcttgaa     2580

aatattaatt acagtcataa atcctaacta cattgagcaa gagaaagaaa gagcaggcac     2640

gcatttccat atgggagtga gccagcagac agcccagcag atcctacaca cattttcaca     2700

aactaacccc agaacaggct gcaaacctat accaatatac tagaaaatgc agattaaatg     2760

gatgaaatat tcaaaactgg agtttacata atgaacgtaa gagtaatcag agaatctgac     2820

tcattttaaa tgtgtgtgta tgtgtgtgta tatatatgtg tgtgtgtgtg tgtgtgtgtg     2880

tgtgtgaaaa acattgactg taataaaaat gttcccatcg taaaaaaaaa aaaaaaa        2937


<210> 112
<211> 597
<212> PRT
<213> Homo sapiens

<400> 112
Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Val Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn 
65                  70                  75                  80  


Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro 
            100                 105                 110         


Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys 
    130                 135                 140                 


Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu 
145                 150                 155                 160 


Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser 
                165                 170                 175     


Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp 
            180                 185                 190         


Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser 
        195                 200                 205             


Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys 
    210                 215                 220                 


Pro Ser Leu Ser Val Gln Pro Gly Pro Val Met Ala Pro Gly Glu Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Cys Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Arg Gly Thr Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu 
385                 390                 395                 400 


Asn Ser Asp Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Val Val Ser Gly Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro 
            420                 425                 430         


Ile Ser Thr Pro Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
        435                 440                 445             


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly Ile 
    450                 455                 460                 


Leu Val Ala Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu 
465                 470                 475                 480 


Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg 
                485                 490                 495     


Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr 
            500                 505                 510         


Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu 
        515                 520                 525             


Glu Asn Leu Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly Val 
    530                 535                 540                 


Glu Met Asp Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr 
545                 550                 555                 560 


Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu Pro 
                565                 570                 575     


Pro Pro Ser Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr Ala 
            580                 585                 590         


Thr Leu Ala Ile His 
        595         


<210> 113
<211> 2799
<212> DNA
<213> Homo sapiens

<400> 113
ggggaagcca ctgctaccct catcaggaag ggcagacaca agaagcacca gttctatttg       60

ctgctacatc ccggctctcg caccgagggc tcatccatcc gcagagcagg gcagtgggag      120

gagacgccat gacccccatc gtcacagtcc tgatctgtct cgggctgagt ctgggcccca      180

ggacccgcgt gcagacaggg accatcccca agcccaccct gtgggctgag ccagactctg      240

tgatcaccca ggggagtccc gtcaccctca gttgtcaggg gagccttgaa gcccaggagt      300

accgtctata tagggagaaa aaatcagcat cttggattac acggatacga ccagagcttg      360

tgaagaacgg ccagttccac atcccatcca tcacctggga acacacaggg cgatatggct      420

gtcagtatta cagccgcgct cggtggtctg agctcagtga ccccctggtg ctggtgatga      480

caggagccta cccaaaaccc accctctcag cccagcccag ccctgtggtg acctcaggag      540

gaagggtgac cctccagtgt gagtcacagg tggcatttgg cggcttcatt ctgtgtaagg      600

aaggagaaga tgaacaccca caatgcctga actcccagcc ccatgcccgt gggtcgtccc      660

gcgccatctt ctccgtgggc cccgtgagcc cgaatcgcag gtggtcgcac aggtgctatg      720

gttatgactt gaactctccc tatgtgtggt cttcacccag tgatctcctg gagctcctgg      780

tcccaggtgt ttctaagaag ccatcactct cagtgcagcc gggtcctgtc atggcccctg      840

gggaaagcct gaccctccag tgtgtctctg atgtcggcta tgacagattt gttctgtaca      900

aggaggggga acgtgacctt cgccagctcc ctggccggca gccccaggct gggctctccc      960

aggccaactt caccctgggc cctgtgagcc gctcctacgg gggccagtac agatgctacg     1020

gtgcacacaa cctctcctct gagtgctcgg cccccagcga ccccctggac atcctgatca     1080

caggacagat ccgtggcaca cccttcatct cagtgcagcc aggccccaca gtggcctcag     1140

gagagaacgt gaccctgctg tgtcagtcat ggcggcagtt ccacactttc cttctgacca     1200

aggcgggagc agctgatgcc ccactccgtc taagatcaat acacgaatat cctaagtacc     1260

aggctgaatt ccccatgagt cctgtgacct cagcccacgc ggggacctac aggtgctacg     1320

gctcactcaa ctccgacccc tacctgctgt ctcaccccag tgagcccctg gagctcgtgg     1380

tctcaggacc ctccatgggt tccagccccc cacccaccgg tcccatctcc acacctggcc     1440

ctgaggacca gcccctcacc cccactgggt cggatcccca aagtggtctg ggaaggcacc     1500

tgggggttgt gatcggcatc ttggtggccg tcgtcctact gctcctcctc ctcctcctcc     1560

tcttcctcat cctccgacat cgacgtcagg gcaaacactg gacatcgacc cagagaaagg     1620

ctgatttcca acatcctgca ggggctgtgg ggccagagcc cacagacaga ggcctgcagt     1680

ggaggtccag cccagctgcc gacgcccagg aagaaaacct ctatgctgcc gtgaaggaca     1740

cacagcctga agatggggtg gagatggaca ctcgggctgc tgcatctgaa gccccccagg     1800

atgtgaccta cgcccagctg cacagcttga ccctcagacg gaaggcaact gagcctcctc     1860

catcccagga aagggaacct ccagctgagc ccagcatcta cgccaccctg gccatccact     1920

agcccggagg gtacgcagac tccacactca gtagaaggag actcaggact gctgaaggca     1980

cgggagctgc ccccagtgga caccaatgaa ccccagtcag cctggacccc taacaaagac     2040

catgaggaga tgctgggaac tttgggactc acttgattct gcagtcgaaa taactaatat     2100

ccctacattt tttaattaaa gcaacagact tctcaataat caatgagtta accgagaaaa     2160

ctaaaatcag aagtaagaat gtgctttaaa ctgaatcaca atataaatat tacacatcac     2220

acaatgaaat tgaaaaagta caaaccacaa atgaaaaaag tagaaacgaa aaaaaaaaac     2280

taggaaatga atgacgttgg ctttcgtata aggaatttag aaaaagaata accaattatt     2340

ccaaatgaag gtgtaagaaa gggaataaga agaagaagag ttgctcatga ggaaaaacca     2400

aaacttgaaa attcaacaaa gccaatgaag ctcattcttg aaaatattaa ttacagtcat     2460

aaatcctaac tacattgagc aagagaaaga aagagcaggc acgcatttcc atatgggagt     2520

gagccagcag acagcccagc agatcctaca cacattttca caaactaacc ccagaacagg     2580

ctgcaaacct ataccaatat actagaaaat gcagattaaa tggatgaaat attcaaaact     2640

ggagtttaca taatgaacgt aagagtaatc agagaatctg actcatttta aatgtgtgtg     2700

tatgtgtgtg tatatatatg tgtgtgtgtg tgtgtgtgtg tgtgtgtgaa aaacattgac     2760

tgtaataaaa atgttcccat cgtaaaaaaa aaaaaaaaa                            2799


<210> 114
<211> 2789
<212> DNA
<213> Homo sapiens

<400> 114
atttggttga aagaaaaccc acaatccagt gtcaagaaag aagtcaactt ttcttcccct       60

acttccctgc atttctcctc tgtgctcact gccacacaca gctcaacctg gacagcacag      120

ccagaggcga gatgcttctc tgctgatctg agtctgcctg cagcatggac ctgggtcttc      180

cctgaagcat ctccagggct ggagggacga ctgccatgca ccgagggctc atccatccgc      240

agagcagggc agtgggagga gacgccatga cccccatcgt cacagtcctg atctgtctcg      300

ggagaaaaaa tcagcatctt ggattacacg gatacgacca gagcttgtga agaacggcca      360

gttccacatc ccatccatca cctgggaaca cacagggcga tatggctgtc agtattacag      420

ccgcgctcgg tggtctgagc tcagtgaccc cctggtgctg gtgatgacag gagcctaccc      480

aaaacccacc ctctcagccc agcccagccc tgtggtgacc tcaggaggaa gggtgaccct      540

ccagtgtgag tcacaggtgg catttggcgg cttcattctg tgtaaggaag gagaagatga      600

acacccacaa tgcctgaact cccagcccca tgcccgtggg tcgtcccgcg ccatcttctc      660

cgtgggcccc gtgagcccga atcgcaggtg gtcgcacagg tgctatggtt atgacttgaa      720

ctctccctat gtgtggtctt cacccagtga tctcctggag ctcctggtcc caggtgtttc      780

taagaagcca tcactctcag tgcagccggg tcctgtcatg gcccctgggg aaagcctgac      840

cctccagtgt gtctctgatg tcggctatga cagatttgtt ctgtacaagg agggggaacg      900

tgaccttcgc cagctccctg gccggcagcc ccaggctggg ctctcccagg ccaacttcac      960

cctgggccct gtgagccgct cctacggggg ccagtacaga tgctacggtg cacacaacct     1020

ctcctctgag tgctcggccc ccagcgaccc cctggacatc ctgatcacag gacagatccg     1080

tggcacaccc ttcatctcag tgcagccagg ccccacagtg gcctcaggag agaacgtgac     1140

cctgctgtgt cagtcatggc ggcagttcca cactttcctt ctgaccaagg cgggagcagc     1200

tgatgcccca ctccgtctaa gatcaataca cgaatatcct aagtaccagg ctgaattccc     1260

catgagtcct gtgacctcag cccacgcggg gacctacagg tgctacggct cactcaactc     1320

cgacccctac ctgctgtctc accccagtga gcccctggag ctcgtggtct caggaccctc     1380

catgggttcc agccccccac ccaccggtcc catctccaca cctgcaggcc ctgaggacca     1440

gcccctcacc cccactgggt cggatcccca aagtggtctg ggaaggcacc tgggggttgt     1500

gatcggcatc ttggtggccg tcgtcctact gctcctcctc ctcctcctcc tcttcctcat     1560

cctccgacat cgacgtcagg gcaaacactg gacatcgacc cagagaaagg ctgatttcca     1620

acatcctgca ggggctgtgg ggccagagcc cacagacaga ggcctgcagt ggaggtccag     1680

cccagctgcc gacgcccagg aagaaaacct ctatgctgcc gtgaaggaca cacagcctga     1740

agatggggtg gagatggaca ctcgggctgc tgcatctgaa gccccccagg atgtgaccta     1800

cgcccagctg cacagcttga ccctcagacg gaaggcaact gagcctcctc catcccagga     1860

aagggaacct ccagctgagc ccagcatcta cgccaccctg gccatccact agcccggagg     1920

gtacgcagac tccacactca gtagaaggag actcaggact gctgaaggca cgggagctgc     1980

ccccagtgga caccaatgaa ccccagtcag cctggacccc taacaaagac catgaggaga     2040

tgctgggaac tttgggactc acttgattct gcagtcgaaa taactaatat ccctacattt     2100

tttaattaaa gcaacagact tctcaataat caatgagtta accgagaaaa ctaaaatcag     2160

aagtaagaat gtgctttaaa ctgaatcaca atataaatat tacacatcac acaatgaaat     2220

tgaaaaagta caaaccacaa atgaaaaaag tagaaacgaa aaaaaaaaac taggaaatga     2280

atgacgttgg ctttcgtata aggaatttag aaaaagaata accaattatt ccaaatgaag     2340

gtgtaagaaa gggaataaga agaagaagag ttgctcatga ggaaaaacca aaacttgaaa     2400

attcaacaaa gccaatgaag ctcattcttg aaaatattaa ttacagtcat aaatcctaac     2460

tacattgagc aagagaaaga aagagcaggc acgcatttcc atatgggagt gagccagcag     2520

acagcccagc agatcctaca cacattttca caaactaacc ccagaacagg ctgcaaacct     2580

ataccaatat actagaaaat gcagattaaa tggatgaaat attcaaaact ggagtttaca     2640

taatgaacgt aagagtaatc agagaatctg actcatttta aatgtgtgtg tatgtgtgtg     2700

tatatatatg tgtgtgtgtg tgtgtgtgtg tgtgtgtgaa aaacattgac tgtaataaaa     2760

atgttcccat cgtaaaaaaa aaaaaaaaa                                       2789


<210> 115
<211> 482
<212> PRT
<213> Homo sapiens

<400> 115
Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro 
1               5                   10                  15      


Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val 
            20                  25                  30          


Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His Pro 
        35                  40                  45              


Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile 
    50                  55                  60                  


Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys 
65                  70                  75                  80  


Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp 
                85                  90                  95      


Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Leu Ser 
            100                 105                 110         


Val Gln Pro Gly Pro Val Met Ala Pro Gly Glu Ser Leu Thr Leu Gln 
        115                 120                 125             


Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Gly 
    130                 135                 140                 


Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro Gln Ala Gly Leu 
145                 150                 155                 160 


Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly 
                165                 170                 175     


Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Cys Ser Ala 
            180                 185                 190         


Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Ile Arg Gly Thr 
        195                 200                 205             


Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn 
    210                 215                 220                 


Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His Thr Phe Leu Leu 
225                 230                 235                 240 


Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu Arg Ser Ile His 
                245                 250                 255     


Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser 
            260                 265                 270         


Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu Asn Ser Asp Pro 
        275                 280                 285             


Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu Val Val Ser Gly 
    290                 295                 300                 


Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro Ile Ser Thr Pro 
305                 310                 315                 320 


Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln 
                325                 330                 335     


Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly Ile Leu Val Ala 
            340                 345                 350         


Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu Ile Leu Arg 
        355                 360                 365             


His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp 
    370                 375                 380                 


Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly 
385                 390                 395                 400 


Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu 
                405                 410                 415     


Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly Val Glu Met Asp 
            420                 425                 430         


Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln 
        435                 440                 445             


Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu Pro Pro Pro Ser 
    450                 455                 460                 


Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr Ala Thr Leu Ala 
465                 470                 475                 480 


Ile His 
        


<210> 116
<211> 2646
<212> DNA
<213> Homo sapiens

<400> 116
caccgagggc tcatccatcc gcagagcagg gcagtgggag gagacgccat gacccccatc       60

gtcacagtcc tgatctgtct cgggctgagt ctgggcccca ggacccgcgt gcagacaggg      120

accatcccca agcccaccct gtgggctgag ccagactctg tgatcaccca ggggagtccc      180

gtcaccctca gttgtcaggg gagccttgaa gcccaggagt accgtctata tagggagaaa      240

aaatcagcat cttggattac acggatacga ccagagcttg tgaagaacgg ccagttccac      300

atcccatcca tcacctggga acacacaggg cgatatggct gtcagtatta cagccgcgct      360

cggtggtctg agctcagtga ccccctggtg ctggtgatga caggagccta cccaaaaccc      420

accctctcag cccagcccag ccctgtggtg acctcaggag gaagggtgac cctccagtgt      480

gagtcacagg tggcatttgg cggcttcatt ctgtgtaagg aaggagaaga tgaacaccca      540

caatgcctga actcccagcc ccatgcccgt gggtcgtccc gcgccatctt ctccgtgggc      600

cccgtgagcc cgaatcgcag gtggtcgcac aggtgctatg gttatgactt gaactctccc      660

tatgtgtggt cttcacccag tgatctcctg gagctcctgg tcccaggtgt ttctaagaag      720

ccatcactct cagtgcagcc gggtcctgtc atggcccctg gggaaagcct gaccctccag      780

tgtgtctctg atgtcggcta tgacagattt gttctgtaca aggaggggga acgtgacctt      840

cgccagctcc ctggccggca gccccaggct gggctctccc aggccaactt caccctgggc      900

cctgtgagcc gctcctacgg gggccagtac agatgctacg gtgcacacaa cctctcctct      960

gagtgctcgg cccccagcga ccccctggac atcctgatca caggacagat ccgtggcaca     1020

cccttcatct cagtgcagcc aggccccaca gtggcctcag gagagaacgt gaccctgctg     1080

tgtcagtcat ggcggcagtt ccacactttc cttctgacca aggcgggagc agctgatgcc     1140

ccactccgtc taagatcaat acacgaatat cctaagtacc aggctgaatt ccccatgagt     1200

cctgtgacct cagcccacgc ggggacctac aggtgctacg gctcactcaa ctccgacccc     1260

tacctgctgt ctcaccccag tgagcccctg gagctcgtgg tctcaggacc ctccatgggt     1320

tccagccccc cacccaccgg tcccatctcc acacctgcag gccctgagga ccagcccctc     1380

acccccactg ggtcggatcc ccaaagtggt ctgggaaggc acctgggggt tgtgatcggc     1440

atcttggtgg ccgtcgtcct actgctcctc ctcctcctcc tcctcttcct catcctccga     1500

catcgacgtc agggcaaaca ctggacatcg agtccagccc agctgccgac gcccaggaag     1560

aaaacctcta tgctgccgtg aaggacacac agcctgaaga tggggtggag atggacactc     1620

gggctgctgc atctgaagcc ccccaggatg tgacctacgc ccagctgcac agcttgaccc     1680

tcagacggaa ggcaactgag cctcctccat cccaggaaag ggaacctcca gctgagccca     1740

gcatctacgc caccctggcc atccactagc ccggagggta cgcagactcc acactcagta     1800

gaaggagact caggactgct gaaggcacgg gagctgcccc cagtggacac caatgaaccc     1860

cagtcagcct ggacccctaa caaagaccat gaggagatgc tgggaacttt gggactcact     1920

tgattctgca gtcgaaataa ctaatatccc tacatttttt aattaaagca acagacttct     1980

caataatcaa tgagttaacc gagaaaacta aaatcagaag taagaatgtg ctttaaactg     2040

aatcacaata taaatattac acatcacaca atgaaattga aaaagtacaa accacaaatg     2100

aaaaaagtag aaacgaaaaa aaaaaactag gaaatgaatg acgttggctt tcgtataagg     2160

aatttagaaa aagaataacc aattattcca aatgaaggtg taagaaaggg aataagaaga     2220

agaagagttg ctcatgagga aaaaccaaaa cttgaaaatt caacaaagcc aatgaagctc     2280

attcttgaaa atattaatta cagtcataaa tcctaactac attgagcaag agaaagaaag     2340

agcaggcacg catttccata tgggagtgag ccagcagaca gcccagcaga tcctacacac     2400

attttcacaa actaacccca gaacaggctg caaacctata ccaatatact agaaaatgca     2460

gattaaatgg atgaaatatt caaaactgga gtttacataa tgaacgtaag agtaatcaga     2520

gaatctgact cattttaaat gtgtgtgtat gtgtgtgtat atatatgtgt gtgtgtgtgt     2580

gtgtgtgtgt gtgtgaaaaa cattgactgt aataaaaatg ttcccatcgt aaaaaaaaaa     2640

aaaaaa                                                                2646


<210> 117
<211> 510
<212> PRT
<213> Homo sapiens

<400> 117
Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Val Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn 
65                  70                  75                  80  


Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro 
            100                 105                 110         


Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys 
    130                 135                 140                 


Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu 
145                 150                 155                 160 


Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser 
                165                 170                 175     


Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp 
            180                 185                 190         


Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser 
        195                 200                 205             


Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys 
    210                 215                 220                 


Pro Ser Leu Ser Val Gln Pro Gly Pro Val Met Ala Pro Gly Glu Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Cys Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Arg Gly Thr Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu 
385                 390                 395                 400 


Asn Ser Asp Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Val Val Ser Gly Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro 
            420                 425                 430         


Ile Ser Thr Pro Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Ser Pro 
                485                 490                 495     


Ala Gln Leu Pro Thr Pro Arg Lys Lys Thr Ser Met Leu Pro 
            500                 505                 510 


<210> 118
<211> 1422
<212> DNA
<213> Homo sapiens

<400> 118
caccgagggc tcatccatcc gcagagcagg gcagtgggag gagacgccat gacccccatc       60

gtcacagtcc tgatctgtct cgggctgagt ctgggcccca ggacccgcgt gcagacaggg      120

accatcccca agcccaccct gtgggctgag ccagactctg tgatcaccca ggggagtccc      180

gtcaccctca gttgtcaggg gagccttgaa gcccaggagt accgtctata tagggagaaa      240

aaatcagcat cttggattac acggatacga ccagagcttg tgaagaacgg ccagttccac      300

atcccatcca tcacctggga acacacaggg cgatatggct gtcagtatta cagccgcgct      360

cggtggtctg agctcagtga ccccctggtg ctggtgatga caggagccta cccaaaaccc      420

accctctcag cccagcccag ccctgtggtg acctcaggag gaagggtgac cctccagtgt      480

gagtcacagg tggcatttgg cggcttcatt ctgtgtaagg aaggagaaga tgaacaccca      540

caatgcctga actcccagcc ccatgcccgt gggtcgtccc gcgccatctt ctccgtgggc      600

cccgtgagcc cgaatcgcag gtggtcgcac aggtgctatg gttatgactt gaactctccc      660

tatgtgtggt cttcacccag tgatctcctg gagctcctgg tcccaggtgt ttctaagaag      720

ccatcactct cagtgcagcc gggtcctgtc atggcccctg gggaaagcct gaccctccag      780

tgtgtctctg atgtcggcta tgacagattt gttctgtaca aggaggggga acgtgacctt      840

cgccagctcc ctggccggca gccccaggct gggctctccc aggccaactt caccctgggc      900

cctgtgagcc gctcctacgg gggccagtac agatgctacg gtgcacacaa cctctcctct      960

gagtgctcgg cccccagcga ccccctggac atcctgatca caggacagat ccgtggcaca     1020

cccttcatct cagtgcagcc aggccccaca gtggcctcag gagagaacgt gaccctgctg     1080

tgtcagtcat ggcggcagtt ccacactttc cttctgacca aggcgggagc agctgatgcc     1140

ccactccgtc taagatcaat acacgaatat cctaagtacc aggctgaatt ccccatgagt     1200

cctgtgacct cagcccacgc ggggacctac aggtgctacg gctcactcaa ctccgacccc     1260

tacctgctgt ctcaccccag tgagcccctg gagctcgtgg tctcaggacc ctccatgggt     1320

tccagccccc cacccaccgg tcccatctcc acacctgcag gccctgagga ccagcccctc     1380

acccccactg ggtcggatcc ccaaagtggt gagtgagggg ct                        1422


<210> 119
<211> 455
<212> PRT
<213> Homo sapiens

<400> 119
Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Val Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn 
65                  70                  75                  80  


Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro 
            100                 105                 110         


Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys 
    130                 135                 140                 


Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu 
145                 150                 155                 160 


Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser 
                165                 170                 175     


Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp 
            180                 185                 190         


Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser 
        195                 200                 205             


Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys 
    210                 215                 220                 


Pro Ser Leu Ser Val Gln Pro Gly Pro Val Met Ala Pro Gly Glu Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Cys Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Arg Gly Thr Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu 
385                 390                 395                 400 


Asn Ser Asp Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Val Val Ser Gly Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro 
            420                 425                 430         


Ile Ser Thr Pro Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Glu 
    450                 455 


<210> 120
<211> 3686
<212> DNA
<213> Homo sapiens

<400> 120
cttcagatag attatatctg gagtgaagaa tcctgccacc tatgtatctg gcatagtatt       60

ctgtgtagtg ggatgagcag agaacaaaaa caaaataatc cagtgagaaa agcccgtaaa      120

taaaccttca gaccagagat ctattctcta gcttatttta agctcaactt aaaaagaaga      180

actgttctct gattcttttc gccttcaata cacttaatga tttaactcca ccctccttca      240

aaagaaacag catttcctac ttttatactg tctatatgat tgatttgcac agctcatctg      300

gccagaagag ctgagacatc cgttccccta caagaaactc tccccgggtg gaacaagatg      360

gattatcaag tgtcaagtcc aatctatgac atcaattatt atacatcgga gccctgccaa      420

aaaatcaatg tgaagcaaat cgcagcccgc ctcctgcctc cgctctactc actggtgttc      480

atctttggtt ttgtgggcaa catgctggtc atcctcatcc tgataaactg caaaaggctg      540

aagagcatga ctgacatcta cctgctcaac ctggccatct ctgacctgtt tttccttctt      600

actgtcccct tctgggctca ctatgctgcc gcccagtggg actttggaaa tacaatgtgt      660

caactcttga cagggctcta ttttataggc ttcttctctg gaatcttctt catcatcctc      720

ctgacaatcg ataggtacct ggctgtcgtc catgctgtgt ttgctttaaa agccaggacg      780

gtcacctttg gggtggtgac aagtgtgatc acttgggtgg tggctgtgtt tgcgtctctc      840

ccaggaatca tctttaccag atctcaaaaa gaaggtcttc attacacctg cagctctcat      900

tttccataca gtcagtatca attctggaag aatttccaga cattaaagat agtcatcttg      960

gggctggtcc tgccgctgct tgtcatggtc atctgctact cgggaatcct aaaaactctg     1020

cttcggtgtc gaaatgagaa gaagaggcac agggctgtga ggcttatctt caccatcatg     1080

attgtttatt ttctcttctg ggctccctac aacattgtcc ttctcctgaa caccttccag     1140

gaattctttg gcctgaataa ttgcagtagc tctaacaggt tggaccaagc tatgcaggtg     1200

acagagactc ttgggatgac gcactgctgc atcaacccca tcatctatgc ctttgtcggg     1260

gagaagttca gaaactacct cttagtcttc ttccaaaagc acattgccaa acgcttctgc     1320

aaatgctgtt ctattttcca gcaagaggct cccgagcgag caagctcagt ttacacccga     1380

tccactgggg agcaggaaat atctgtgggc ttgtgacacg gactcaagtg ggctggtgac     1440

ccagtcagag ttgtgcacat ggcttagttt tcatacacag cctgggctgg gggtggggtg     1500

ggagaggtct tttttaaaag gaagttactg ttatagaggg tctaagattc atccatttat     1560

ttggcatctg tttaaagtag attagatctt ttaagcccat caattataga aagccaaatc     1620

aaaatatgtt gatgaaaaat agcaaccttt ttatctcccc ttcacatgca tcaagttatt     1680

gacaaactct cccttcactc cgaaagttcc ttatgtatat ttaaaagaaa gcctcagaga     1740

attgctgatt cttgagttta gtgatctgaa cagaaatacc aaaattattt cagaaatgta     1800

caacttttta cctagtacaa ggcaacatat aggttgtaaa tgtgtttaaa acaggtcttt     1860

gtcttgctat ggggagaaaa gacatgaata tgattagtaa agaaatgaca cttttcatgt     1920

gtgatttccc ctccaaggta tggttaataa gtttcactga cttagaacca ggcgagagac     1980

ttgtggcctg ggagagctgg ggaagcttct taaatgagaa ggaatttgag ttggatcatc     2040

tattgctggc aaagacagaa gcctcactgc aagcactgca tgggcaagct tggctgtaga     2100

aggagacaga gctggttggg aagacatggg gaggaaggac aaggctagat catgaagaac     2160

cttgacggca ttgctccgtc taagtcatga gctgagcagg gagatcctgg ttggtgttgc     2220

agaaggttta ctctgtggcc aaaggagggt caggaaggat gagcatttag ggcaaggaga     2280

ccaccaacag ccctcaggtc agggtgagga tggcctctgc taagctcaag gcgtgaggat     2340

gggaaggagg gaggtattcg taaggatggg aaggagggag gtattcgtgc agcatatgag     2400

gatgcagagt cagcagaact ggggtggatt tgggttggaa gtgagggtca gagaggagtc     2460

agagagaatc cctagtcttc aagcagattg gagaaaccct tgaaaagaca tcaagcacag     2520

aaggaggagg aggaggttta ggtcaagaag aagatggatt ggtgtaaaag gatgggtctg     2580

gtttgcagag cttgaacaca gtctcaccca gactccaggc tgtctttcac tgaatgcttc     2640

tgacttcata gatttccttc ccatcccagc tgaaatactg aggggtctcc aggaggagac     2700

tagatttatg aatacacgag gtatgaggtc taggaacata cttcagctca cacatgagat     2760

ctaggtgagg attgattacc tagtagtcat ttcatgggtt gttgggagga ttctatgagg     2820

caaccacagg cagcatttag cacatactac acattcaata agcatcaaac tcttagttac     2880

tcattcaggg atagcactga gcaaagcatt gagcaaaggg gtcccataga ggtgagggaa     2940

gcctgaaaaa ctaagatgct gcctgcccag tgcacacaag tgtaggtatc attttctgca     3000

tttaaccgtc aataggcaaa ggggggaagg gacatattca tttggaaata agctgccttg     3060

agccttaaaa cccacaaaag tacaatttac cagcctccgt atttcagact gaatgggggt     3120

ggggggggcg ccttaggtac ttattccaga tgccttctcc agacaaacca gaagcaacag     3180

aaaaaatcgt ctctccctcc ctttgaaatg aatatacccc ttagtgtttg ggtatattca     3240

tttcaaaggg agagagagag gtttttttct gttctgtctc atatgattgt gcacatactt     3300

gagactgttt tgaatttggg ggatggctaa aaccatcata gtacaggtaa ggtgagggaa     3360

tagtaagtgg tgagaactac tcagggaatg aaggtgtcag aataataaga ggtgctactg     3420

actttctcag cctctgaata tgaacggtga gcattgtggc tgtcagcagg aagcaacgaa     3480

gggaaatgtc tttccttttg ctcttaagtt gtggagagtg caacagtagc ataggaccct     3540

accctctggg ccaagtcaaa gacattctga catcttagta tttgcatatt cttatgtatg     3600

tgaaagttac aaattgcttg aaagaaaata tgcatctaat aaaaaacacc ttctaaaata     3660

aaaaaaaaaa aaaaaaaaaa aaaaaa                                          3686


<210> 121
<211> 3451
<212> DNA
<213> Homo sapiens

<400> 121
cttcagatag attatatctg gagtgaagaa tcctgccacc tatgtatctg gcatagtctc       60

atctggccag aagagctgag acatccgttc ccctacaaga aactctcccc gggtggaaca      120

agatggatta tcaagtgtca agtccaatct atgacatcaa ttattataca tcggagccct      180

gccaaaaaat caatgtgaag caaatcgcag cccgcctcct gcctccgctc tactcactgg      240

tgttcatctt tggttttgtg ggcaacatgc tggtcatcct catcctgata aactgcaaaa      300

ggctgaagag catgactgac atctacctgc tcaacctggc catctctgac ctgtttttcc      360

ttcttactgt ccccttctgg gctcactatg ctgccgccca gtgggacttt ggaaatacaa      420

tgtgtcaact cttgacaggg ctctatttta taggcttctt ctctggaatc ttcttcatca      480

tcctcctgac aatcgatagg tacctggctg tcgtccatgc tgtgtttgct ttaaaagcca      540

ggacggtcac ctttggggtg gtgacaagtg tgatcacttg ggtggtggct gtgtttgcgt      600

ctctcccagg aatcatcttt accagatctc aaaaagaagg tcttcattac acctgcagct      660

ctcattttcc atacagtcag tatcaattct ggaagaattt ccagacatta aagatagtca      720

tcttggggct ggtcctgccg ctgcttgtca tggtcatctg ctactcggga atcctaaaaa      780

ctctgcttcg gtgtcgaaat gagaagaaga ggcacagggc tgtgaggctt atcttcacca      840

tcatgattgt ttattttctc ttctgggctc cctacaacat tgtccttctc ctgaacacct      900

tccaggaatt ctttggcctg aataattgca gtagctctaa caggttggac caagctatgc      960

aggtgacaga gactcttggg atgacgcact gctgcatcaa ccccatcatc tatgcctttg     1020

tcggggagaa gttcagaaac tacctcttag tcttcttcca aaagcacatt gccaaacgct     1080

tctgcaaatg ctgttctatt ttccagcaag aggctcccga gcgagcaagc tcagtttaca     1140

cccgatccac tggggagcag gaaatatctg tgggcttgtg acacggactc aagtgggctg     1200

gtgacccagt cagagttgtg cacatggctt agttttcata cacagcctgg gctgggggtg     1260

gggtgggaga ggtctttttt aaaaggaagt tactgttata gagggtctaa gattcatcca     1320

tttatttggc atctgtttaa agtagattag atcttttaag cccatcaatt atagaaagcc     1380

aaatcaaaat atgttgatga aaaatagcaa cctttttatc tccccttcac atgcatcaag     1440

ttattgacaa actctccctt cactccgaaa gttccttatg tatatttaaa agaaagcctc     1500

agagaattgc tgattcttga gtttagtgat ctgaacagaa ataccaaaat tatttcagaa     1560

atgtacaact ttttacctag tacaaggcaa catataggtt gtaaatgtgt ttaaaacagg     1620

tctttgtctt gctatgggga gaaaagacat gaatatgatt agtaaagaaa tgacactttt     1680

catgtgtgat ttcccctcca aggtatggtt aataagtttc actgacttag aaccaggcga     1740

gagacttgtg gcctgggaga gctggggaag cttcttaaat gagaaggaat ttgagttgga     1800

tcatctattg ctggcaaaga cagaagcctc actgcaagca ctgcatgggc aagcttggct     1860

gtagaaggag acagagctgg ttgggaagac atggggagga aggacaaggc tagatcatga     1920

agaaccttga cggcattgct ccgtctaagt catgagctga gcagggagat cctggttggt     1980

gttgcagaag gtttactctg tggccaaagg agggtcagga aggatgagca tttagggcaa     2040

ggagaccacc aacagccctc aggtcagggt gaggatggcc tctgctaagc tcaaggcgtg     2100

aggatgggaa ggagggaggt attcgtaagg atgggaagga gggaggtatt cgtgcagcat     2160

atgaggatgc agagtcagca gaactggggt ggatttgggt tggaagtgag ggtcagagag     2220

gagtcagaga gaatccctag tcttcaagca gattggagaa acccttgaaa agacatcaag     2280

cacagaagga ggaggaggag gtttaggtca agaagaagat ggattggtgt aaaaggatgg     2340

gtctggtttg cagagcttga acacagtctc acccagactc caggctgtct ttcactgaat     2400

gcttctgact tcatagattt ccttcccatc ccagctgaaa tactgagggg tctccaggag     2460

gagactagat ttatgaatac acgaggtatg aggtctagga acatacttca gctcacacat     2520

gagatctagg tgaggattga ttacctagta gtcatttcat gggttgttgg gaggattcta     2580

tgaggcaacc acaggcagca tttagcacat actacacatt caataagcat caaactctta     2640

gttactcatt cagggatagc actgagcaaa gcattgagca aaggggtccc atagaggtga     2700

gggaagcctg aaaaactaag atgctgcctg cccagtgcac acaagtgtag gtatcatttt     2760

ctgcatttaa ccgtcaatag gcaaaggggg gaagggacat attcatttgg aaataagctg     2820

ccttgagcct taaaacccac aaaagtacaa tttaccagcc tccgtatttc agactgaatg     2880

ggggtggggg gggcgcctta ggtacttatt ccagatgcct tctccagaca aaccagaagc     2940

aacagaaaaa atcgtctctc cctccctttg aaatgaatat accccttagt gtttgggtat     3000

attcatttca aagggagaga gagaggtttt tttctgttct gtctcatatg attgtgcaca     3060

tacttgagac tgttttgaat ttgggggatg gctaaaacca tcatagtaca ggtaaggtga     3120

gggaatagta agtggtgaga actactcagg gaatgaaggt gtcagaataa taagaggtgc     3180

tactgacttt ctcagcctct gaatatgaac ggtgagcatt gtggctgtca gcaggaagca     3240

acgaagggaa atgtctttcc ttttgctctt aagttgtgga gagtgcaaca gtagcatagg     3300

accctaccct ctgggccaag tcaaagacat tctgacatct tagtatttgc atattcttat     3360

gtatgtgaaa gttacaaatt gcttgaaaga aaatatgcat ctaataaaaa acaccttcta     3420

aaataaaaaa aaaaaaaaaa aaaaaaaaaa a                                    3451


<210> 122
<211> 352
<212> PRT
<213> Homo sapiens

<400> 122
Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210> 123
<211> 2009
<212> DNA
<213> Homo sapiens

<400> 123
agaaactatt tcagtttgct agaggaacat tttaaatctg aattgaacca cccattttcc       60

tttcttagcc aaatcaccaa aatgtccagt tagaacaaga atttagcatt ctgcaaaaga      120

agttaacagc tgagataacg aggaaatatt ctgaaatgga tcccaaatat ttcatcttaa      180

ttttgttttg tggacacctg aacaatacat ttttttcaaa gacagagaca attacaacag      240

agaagcagtc acagcctacc ttattcacat catcaatgtc acaggtattg gctaattctc      300

aaaacacaac agggaatcct ttgggtcaac caacacaatt cagcgacact ttttctggac      360

aatcaatatc acctgccaaa gtcactgctg gacaaccaac accagctgtc tatacctctt      420

ctgaaaaacc agaagcacat acttctgctg gacaaccact tgcctacaac accaaacaac      480

caacaccaat agccaacacc tcctcccagc aagccgtgtt cacctctgcc agacaactac      540

catctgcccg tacttctacc acacaaccac caaagtcatt tgtctatact tttactcaac      600

aatcatcatc tgtccagatc ccttctagaa aacaaataac tgttcataat ccatccacac      660

aaccaacatc aactgtcaaa aattcaccta ggagtacacc aggatttatc ttagatacta      720

ccagtaacaa acaaacccca caaaaaaaca attataattc aatagctgcc atactaattg      780

gtgtacttct gacttctatg ttggtagcta taatcatcat tgtactttgg aaatgcttaa      840

ggaaaccagt tttaaatgat caaaattggg caggtagatc tccatttgct gatggagaaa      900

cccctgacat ttgtatggat aacatcagag aaaatgaaat atccacaaaa cgtacatcaa      960

tcatttcact tacaccctgg aaaccaagca aaagcacact tttagcagat gacttagaaa     1020

ttaagttgtt tgaatcaagt gaaaacattg aagactccaa caaccccaaa acagagaaaa     1080

taaaagatca agtaaatggt acatcagaag atagtgctga tggttcaaca gttggaactg     1140

ctgtttcttc ttcagatgat gcagatctgc ctccaccacc tccccttctg gatttggaag     1200

gacaggaaag taaccaatct gacaaaccca caatgacaat tgtatctcct cttccaaatg     1260

attctactag tctccctcca tctctggact gtctcaatca agactgtgga gatcataaat     1320

ctgagataat acaatcattt ccaccgcttg actcacttaa cttgcccctg ccaccagtag     1380

attttatgaa aaaccaagaa gattccaacc ttgagatcca gtgtcaggag ttctctattc     1440

ctcccaactc tgatcaagat cttaatgaat ccctgccacc tccacctgca gaactgttat     1500

aaatattaca acttgctttt tagctgatct tccatcctca aatgactctt ttttctttat     1560

atgttaacat atataaaatg gcaactgata gtcaattttg atttttattc aggaactatc     1620

tgaaatctgc tcagagccta tgtgcataga tgaaactttt ttttaaaaaa agttatttaa     1680

cagtaatcta tttactaatt atagtaccta tctttaaagt atagtacatt ttacatatgt     1740

aaatggtatg tttcaataat ttaagaactc tgaaacaatc tacatatact tattacccag     1800

tacagttttt tttcccctga aaagctgtgt ataaaattat ggtgaataaa cttttatgtt     1860

tccatttcaa agaccagggt ggagaggaat aagagactaa gtatatgctt caagttttaa     1920

attaatacct caagtattaa ataaatattc caagtttgtg ggaatgggag attaaaatgc     1980

atgtttgaga atagaaaaaa aaaaaaaaa                                       2009


<210> 124
<211> 448
<212> PRT
<213> Homo sapiens

<400> 124
Met Asp Pro Lys Tyr Phe Ile Leu Ile Leu Phe Cys Gly His Leu Asn 
1               5                   10                  15      


Asn Thr Phe Phe Ser Lys Thr Glu Thr Ile Thr Thr Glu Lys Gln Ser 
            20                  25                  30          


Gln Pro Thr Leu Phe Thr Ser Ser Met Ser Gln Val Leu Ala Asn Ser 
        35                  40                  45              


Gln Asn Thr Thr Gly Asn Pro Leu Gly Gln Pro Thr Gln Phe Ser Asp 
    50                  55                  60                  


Thr Phe Ser Gly Gln Ser Ile Ser Pro Ala Lys Val Thr Ala Gly Gln 
65                  70                  75                  80  


Pro Thr Pro Ala Val Tyr Thr Ser Ser Glu Lys Pro Glu Ala His Thr 
                85                  90                  95      


Ser Ala Gly Gln Pro Leu Ala Tyr Asn Thr Lys Gln Pro Thr Pro Ile 
            100                 105                 110         


Ala Asn Thr Ser Ser Gln Gln Ala Val Phe Thr Ser Ala Arg Gln Leu 
        115                 120                 125             


Pro Ser Ala Arg Thr Ser Thr Thr Gln Pro Pro Lys Ser Phe Val Tyr 
    130                 135                 140                 


Thr Phe Thr Gln Gln Ser Ser Ser Val Gln Ile Pro Ser Arg Lys Gln 
145                 150                 155                 160 


Ile Thr Val His Asn Pro Ser Thr Gln Pro Thr Ser Thr Val Lys Asn 
                165                 170                 175     


Ser Pro Arg Ser Thr Pro Gly Phe Ile Leu Asp Thr Thr Ser Asn Lys 
            180                 185                 190         


Gln Thr Pro Gln Lys Asn Asn Tyr Asn Ser Ile Ala Ala Ile Leu Ile 
        195                 200                 205             


Gly Val Leu Leu Thr Ser Met Leu Val Ala Ile Ile Ile Ile Val Leu 
    210                 215                 220                 


Trp Lys Cys Leu Arg Lys Pro Val Leu Asn Asp Gln Asn Trp Ala Gly 
225                 230                 235                 240 


Arg Ser Pro Phe Ala Asp Gly Glu Thr Pro Asp Ile Cys Met Asp Asn 
                245                 250                 255     


Ile Arg Glu Asn Glu Ile Ser Thr Lys Arg Thr Ser Ile Ile Ser Leu 
            260                 265                 270         


Thr Pro Trp Lys Pro Ser Lys Ser Thr Leu Leu Ala Asp Asp Leu Glu 
        275                 280                 285             


Ile Lys Leu Phe Glu Ser Ser Glu Asn Ile Glu Asp Ser Asn Asn Pro 
    290                 295                 300                 


Lys Thr Glu Lys Ile Lys Asp Gln Val Asn Gly Thr Ser Glu Asp Ser 
305                 310                 315                 320 


Ala Asp Gly Ser Thr Val Gly Thr Ala Val Ser Ser Ser Asp Asp Ala 
                325                 330                 335     


Asp Leu Pro Pro Pro Pro Pro Leu Leu Asp Leu Glu Gly Gln Glu Ser 
            340                 345                 350         


Asn Gln Ser Asp Lys Pro Thr Met Thr Ile Val Ser Pro Leu Pro Asn 
        355                 360                 365             


Asp Ser Thr Ser Leu Pro Pro Ser Leu Asp Cys Leu Asn Gln Asp Cys 
    370                 375                 380                 


Gly Asp His Lys Ser Glu Ile Ile Gln Ser Phe Pro Pro Leu Asp Ser 
385                 390                 395                 400 


Leu Asn Leu Pro Leu Pro Pro Val Asp Phe Met Lys Asn Gln Glu Asp 
                405                 410                 415     


Ser Asn Leu Glu Ile Gln Cys Gln Glu Phe Ser Ile Pro Pro Asn Ser 
            420                 425                 430         


Asp Gln Asp Leu Asn Glu Ser Leu Pro Pro Pro Pro Ala Glu Leu Leu 
        435                 440                 445             


<210> 125
<211> 3529
<212> DNA
<213> Mus musculus

<400> 125
tactgataaa cttcctctgc tgcacagaag ccgtctcagt gcgctggaga ccaccgttaa       60

tccgcactga aacacccctt tgctctctca gccaaatcac caacatgtcc tgttagaaca      120

agaatttaca ttctgcgaaa gaagttcaca ggagaaaaca tctgaaatgg aattcaagta      180

tctggtcttc attgtgcttt gtcaatacct ggacaatacg tttttctcag agacagaagc      240

aattacaaca gagcagcaat cactgtctac tttaatcaca ccgtcgttat atgttacaac      300

tgattctcaa aacacagcag ggaatgcttt gagtcagaca acaagattca agaacatttc      360

ttctggacag caagcatcac ctgcccaaat cactcctgaa caagcaacac cagctgttta      420

tgtctcttca agcccactta cttataacat taccagacaa gcagaatcag cggtcaacaa      480

ctccttgcct caaacatcac catctgggtt cactttgacc aatcagccat caccttctac      540

ctataattct actggacaac caccaaaaca tcttgtctat acttccacac aacagccacc      600

atcacctgct cctacctctt ctggaaaacc agaagtagag tctactcata atcagcccac      660

aaaatcaaca ccaactattt atttacaaag ggacacacca ccaccaccac caccaccact      720

cacttcagaa ccaccaagtg gcaaaggaac tgctcataaa aacaaccaca atgcaattgc      780

tgccatatta atcggtacta ttataatttc tatgttggta gctatactca tgattatact      840

gtggaaatac ttgaggaagc cagtcttaaa tgatcaaaac tgggcaggta ggtctccatt      900

tgctgatgga gaaacaccag aaatgtgtat ggataacatc agagagagtg aggcatccac      960

aaagcgtgca tcagttgtct cacttatgac ctggaaacca agtaaaagca cactgctagc     1020

agatgattta gaagttaagt tgtttgaatc aagtgaacac attaatgata ccagcaacct     1080

caagactgat aatgtagaag ttcaaataaa tggcttatca gaagacagtg ctgatgggtc     1140

aacagttggt acagccgtgt cttcagatga tgcagatctg gccctgccac ctccccttct     1200

tgatttggat gagaacctac caaacaagcc cacagtgaca gttgtatctc ctttaccaaa     1260

tgattctatc aatccccaac catctccaga tggtctaaat caagtgtgtg aagaacagca     1320

ttccaagatc caagagccat tcccgccacc ccctgactca tttaatgtgc ctctgtcagc     1380

aggagatttt ataaacaatc aagagtcggc ccacgaggct caatgccagg agttctctac     1440

tcctgacctc catccagacc tcacagactc cctgccacct ccacctacag agctgctgta     1500

aagtgacagc tggctttcta gactgccctc catcctgaga tggcaccgac acgttcctgt     1560

cttcgtggta tggcacacag gacatgacac ctggcacctg agagactctt tagggactac     1620

ctgacccctg actgaagccc acgtacacgg gtagattatt acagtggtat gcttaccagc     1680

tacagaagta atttttaaat cagagtgcct tttatatatg ttaatgatag atatttcaat     1740

aacttaatca ctttggaaac atatgatcta catatactta ttattaccca atagatttcc     1800

cccgaaaagc tgtatataaa catatcttaa ataaataaaa ttctattttt tccacctcaa     1860

aatttggggt ataataaaaa tggaaatttt taaatggtca aagttttaat acttcaaata     1920

ttaagtaaat attttcattt atagagatta aacacacagc taccaaactg tattaaaaca     1980

tgaagtctga gtgctgtgtt tgggatacat ttaccctgaa aaagtgagca cttaccataa     2040

aattttcttt tttctttata attaaaaatt ttatgtatat aagagttttg cctgaatatg     2100

tgtgtatata ttcatatagt cacacacaca cacatatata taagacagaa gatggcacta     2160

ctaacatttg ccaatgcccc gtgagtcctg gaactgactc caagtcctct gtaagtgctc     2220

ttaaccaccg agcccctgca actccgttct tcccctcctc ttcctcctcc tcctcttcct     2280

cctcctcttc ctcttcaaat gtttggggcg tgggggtgga ggtcaaagag ataggctgta     2340

tttggggtta gaagatgact tgtgggagtt gatttttttc ttccacctca aggataaaat     2400

tcagaactca agtcatgaga cctgacagca agcaaccttt atcctctaag cccatctcac     2460

tgcccccaaa atgtaaacat ttttctaaaa tgttagggaa gcataaacta accacttaga     2520

caaaaatcaa atgatatgga agacgggaga aaaaaataga agtgggctgt atctgtgtgt     2580

ctcttcccac acatgcatga taccagcctg tgtgagggtg tctgtggaga ccacagagga     2640

taccagccat cctggaactg aagtcccagg aagttatgag ctgctgtcta acacgggtac     2700

tgggaactga acttgggtcc tataggacag cagcaagttc tctaaagtac tgacccatca     2760

ctgcagcccc agcctccttt tgtaaatgca ggaatgtaat catcacctga aggttgttga     2820

gtatgaggca ctcagaacag aagtgggcac aacttttgtt aaagtggagg cggcagtggg     2880

tactggccta ccttttgcag atgtcaaatg ttcatctgcc caacaagcca tccttctctt     2940

attattatta caagtccaag aaaggacagt tgcttagagc acagattttg gcacttttca     3000

agatagtata tagtatttat tggtaacatt aatgttcaaa tactaaaaat cccatgtaga     3060

ataaaaacaa gaaggttctc gggcagtgga gttttactac tactgctact attactacta     3120

catactacta ctattattta gtatataatt atcaataaac aattattata catattataa     3180

atacatgtaa atttattatt gttgttgttt gtgttctgag acaggagtcc tctggtagcc     3240

ctggctgtcc tggcactctc tctctataga cccactgtcc tcaaactcac agatacacct     3300

gcctctgtct cccaatcttt gtgattaacg gtgtgacctt taaacacctt aaaagacact     3360

gggcttaagt gttattttac atacaatact taccttactt cttacaagcc acctcttact     3420

gataacactt tttttatcta cagaaacacc tacttcaagc atgatggcgt ttcattttat     3480

tacattggtt cttttctgtc attcacaata aaatttctca cgtgtcttc                 3529


<210> 126
<211> 444
<212> PRT
<213> Mus musculus

<400> 126
Met Glu Phe Lys Tyr Leu Val Phe Ile Val Leu Cys Gln Tyr Leu Asp 
1               5                   10                  15      


Asn Thr Phe Phe Ser Glu Thr Glu Ala Ile Thr Thr Glu Gln Gln Ser 
            20                  25                  30          


Leu Ser Thr Leu Ile Thr Pro Ser Leu Tyr Val Thr Thr Asp Ser Gln 
        35                  40                  45              


Asn Thr Ala Gly Asn Ala Leu Ser Gln Thr Thr Arg Phe Lys Asn Ile 
    50                  55                  60                  


Ser Ser Gly Gln Gln Ala Ser Pro Ala Gln Ile Thr Pro Glu Gln Ala 
65                  70                  75                  80  


Thr Pro Ala Val Tyr Val Ser Ser Ser Pro Leu Thr Tyr Asn Ile Thr 
                85                  90                  95      


Arg Gln Ala Glu Ser Ala Val Asn Asn Ser Leu Pro Gln Thr Ser Pro 
            100                 105                 110         


Ser Gly Phe Thr Leu Thr Asn Gln Pro Ser Pro Ser Thr Tyr Asn Ser 
        115                 120                 125             


Thr Gly Gln Pro Pro Lys His Leu Val Tyr Thr Ser Thr Gln Gln Pro 
    130                 135                 140                 


Pro Ser Pro Ala Pro Thr Ser Ser Gly Lys Pro Glu Val Glu Ser Thr 
145                 150                 155                 160 


His Asn Gln Pro Thr Lys Ser Thr Pro Thr Ile Tyr Leu Gln Arg Asp 
                165                 170                 175     


Thr Pro Pro Pro Pro Pro Pro Pro Leu Thr Ser Glu Pro Pro Ser Gly 
            180                 185                 190         


Lys Gly Thr Ala His Lys Asn Asn His Asn Ala Ile Ala Ala Ile Leu 
        195                 200                 205             


Ile Gly Thr Ile Ile Ile Ser Met Leu Val Ala Ile Leu Met Ile Ile 
    210                 215                 220                 


Leu Trp Lys Tyr Leu Arg Lys Pro Val Leu Asn Asp Gln Asn Trp Ala 
225                 230                 235                 240 


Gly Arg Ser Pro Phe Ala Asp Gly Glu Thr Pro Glu Met Cys Met Asp 
                245                 250                 255     


Asn Ile Arg Glu Ser Glu Ala Ser Thr Lys Arg Ala Ser Val Val Ser 
            260                 265                 270         


Leu Met Thr Trp Lys Pro Ser Lys Ser Thr Leu Leu Ala Asp Asp Leu 
        275                 280                 285             


Glu Val Lys Leu Phe Glu Ser Ser Glu His Ile Asn Asp Thr Ser Asn 
    290                 295                 300                 


Leu Lys Thr Asp Asn Val Glu Val Gln Ile Asn Gly Leu Ser Glu Asp 
305                 310                 315                 320 


Ser Ala Asp Gly Ser Thr Val Gly Thr Ala Val Ser Ser Asp Asp Ala 
                325                 330                 335     


Asp Leu Ala Leu Pro Pro Pro Leu Leu Asp Leu Asp Glu Asn Leu Pro 
            340                 345                 350         


Asn Lys Pro Thr Val Thr Val Val Ser Pro Leu Pro Asn Asp Ser Ile 
        355                 360                 365             


Asn Pro Gln Pro Ser Pro Asp Gly Leu Asn Gln Val Cys Glu Glu Gln 
    370                 375                 380                 


His Ser Lys Ile Gln Glu Pro Phe Pro Pro Pro Pro Asp Ser Phe Asn 
385                 390                 395                 400 


Val Pro Leu Ser Ala Gly Asp Phe Ile Asn Asn Gln Glu Ser Ala His 
                405                 410                 415     


Glu Ala Gln Cys Gln Glu Phe Ser Thr Pro Asp Leu His Pro Asp Leu 
            420                 425                 430         


Thr Asp Ser Leu Pro Pro Pro Pro Thr Glu Leu Leu 
        435                 440                 


<210> 127
<211> 2622
<212> DNA
<213> Homo sapiens

<400> 127
agcatagttt catttcctgc tcttgaatat ctggttgaac tacttaagct taatttgtta       60

aactccggta agtacctagc ccacatgatt tgactcagag attctctttt gtccacagac      120

agtcatctca ggagcagaaa gaaaagagct cccaaatgct atatctattc aggggctctc      180

aagaacaatg gaatatcatc ctgatttaga aaatttggat gaagatggat atactcaatt      240

acacttcgac tctcaaagca ataccaggat agctgttgtt tcagagaaag gatcgtgtgc      300

tgcatctcct ccttggcgcc tcattgctgt aattttggga atcctatgct tggtaatact      360

ggtgatagct gtggtcctgg gtaccatggc tatttggaga tccaattcag gaagcaacac      420

attggagaat ggctactttc tatcaagaaa taaagagaac cacagtcaac ccacacaatc      480

atctttagaa gacagtgtga ctcctaccaa agctgtcaaa accacagggg ttctttccag      540

cccttgtcct cctaattgga ttatatatga gaagagctgt tatctattca gcatgtcact      600

aaattcctgg gatggaagta aaagacaatg ctggcaactg ggctctaatc tcctaaagat      660

agacagctca aatgaattgg gatttatagt aaaacaagtg tcttcccaac ctgataattc      720

attttggata ggcctttctc ggccccagac tgaggtacca tggctctggg aggatggatc      780

aacattctct tctaacttat ttcagatcag aaccacagct acccaagaaa acccatctcc      840

aaattgtgta tggattcacg tgtcagtcat ttatgaccaa ctgtgtagtg tgccctcata      900

tagtatttgt gagaagaagt tttcaatgta agaggaaggg tggagaagga gagagaaata      960

tgtgaggtag taaggaggac agaaaacaga acagaaaaga gtaacagctg aggtcaagat     1020

aaatgcagaa aatgtttaga gagcttggcc aactgtaatc ttaaccaaga aattgaaggg     1080

agaggctgtg atttctgtat ttgtcgacct acaggtaggc tagtattatt tttctagtta     1140

gtagatccct agacatggaa tcagggcagc caagcttgag tttttatttt ttatttattt     1200

atttttttga gatagggtct cactttgtta cccaggctgg agtgcagtgg cacaatctcg     1260

actcactgca gctatctctc gcctcagccc ctcaagtagc tgggactaca ggtgcatgcc     1320

accatgccag gctaattttt ggtgtttttt gtagagactg ggttttgcca tgttgaccaa     1380

gctggtctct aactcctggg cttaagtgat ctgcccgcct tggcctccca aagtgctggg     1440

attacagatg tgagccacca cacctggccc caagcttgaa ttttcattct gccattgact     1500

tggcatttac cttgggtaag ccataagcga atcttaattt ctggctctat cagagttgtt     1560

tcatgctcaa caatgccatt gaagtgcacg gtgtgttgcc acgatttgac cctcaacttc     1620

tagcagtata tcagttatga actgagggtg aaatatattt ctgaatagct aaatgaagaa     1680

atgggaaaaa atcttcacca cagtcagagc aattttatta ttttcatcag tatgatcata     1740

attatgatta tcatcttagt aaaaagcagg aactcctact ttttctttat caattaaata     1800

gctcagagag tacatctgcc atatctctaa tagaatcttt tttttttttt ttttttttga     1860

gacagagttt cgctcttgtt gcccaggctg gagtgcaacg gcacgatctc ggctcaccgc     1920

aacctccgcc ccctgggttc aagcaattct cctgcctcag cctcccaagt agctgggatt     1980

acagtcaggc accaccacac ccggctaatt ttgtattttt ttagtagaga cagggtttct     2040

ccatgtcggt cagggtagtc ccgaactcct gacctcaagt gatctgcctg cctcggcctc     2100

ccaagtgctg ggattacagg cgtgagccac tgcacccagc ctagaatctt gtataatatg     2160

taattgtagg gaaactgctc tcataggaaa gttttctgct ttttaaatac aaaaatacat     2220

aaaaatacat aaaatctgat gatgaatata aaaaagtaac caacctcatt ggaacaagta     2280

ttaacatttt ggaatatgtt ttattagttt tgtgatgtac tgttttacaa tttttaccat     2340

ttttttcagt aattactgta aaatggtatt attggaatga aactatattt cctcatgtgc     2400

tgatttgtct tatttttttc atactttccc actggtgcta tttttatttc caatggatat     2460

ttctgtatta ctagggaggc atttacagtc ctctaatgtt gattaatatg tgaaaagaaa     2520

ttgtaccaat tttactaaat tatgcagttt aaaatggatg attttatgtt atgtggattt     2580

catttcaata aaaaaaaact cttatcaaaa aaaaaaaaaa aa                        2622


<210> 128
<211> 247
<212> PRT
<213> Homo sapiens

<400> 128
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Thr 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Thr Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Thr Met Ala Ile Trp Arg Ser Asn Ser Gly Ser Asn Thr Leu Glu 
65                  70                  75                  80  


Asn Gly Tyr Phe Leu Ser Arg Asn Lys Glu Asn His Ser Gln Pro Thr 
                85                  90                  95      


Gln Ser Ser Leu Glu Asp Ser Val Thr Pro Thr Lys Ala Val Lys Thr 
            100                 105                 110         


Thr Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile Tyr Glu 
        115                 120                 125             


Lys Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp Gly Ser 
    130                 135                 140                 


Lys Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile Asp Ser 
145                 150                 155                 160 


Ser Asn Glu Leu Gly Phe Ile Val Lys Gln Val Ser Ser Gln Pro Asp 
                165                 170                 175     


Asn Ser Phe Trp Ile Gly Leu Ser Arg Pro Gln Thr Glu Val Pro Trp 
            180                 185                 190         


Leu Trp Glu Asp Gly Ser Thr Phe Ser Ser Asn Leu Phe Gln Ile Arg 
        195                 200                 205             


Thr Thr Ala Thr Gln Glu Asn Pro Ser Pro Asn Cys Val Trp Ile His 
    210                 215                 220                 


Val Ser Val Ile Tyr Asp Gln Leu Cys Ser Val Pro Ser Tyr Ser Ile 
225                 230                 235                 240 


Cys Glu Lys Lys Phe Ser Met 
                245         


<210> 129
<211> 2484
<212> DNA
<213> Homo sapiens

<400> 129
agcatagttt catttcctgc tcttgaatat ctggttgaac tacttaagct taatttgtta       60

aactccggta agtacctagc ccacatgatt tgactcagag attctctttt gtccacagac      120

agtcatctca ggagcagaaa gaaaagagct cccaaatgct atatctattc aggggctctc      180

aagaacaatg gaatatcatc ctgatttaga aaatttggat gaagatggat atactcaatt      240

acacttcgac tctcaaagca ataccaggat agctgttgtt tcagagaaag gatcgtgtgc      300

tgcatctcct ccttggcgcc tcattgctgt aattttggga atcctatgct tggtaatact      360

ggtgatagct gtggtcctgg gtaccatggg ggttctttcc agcccttgtc ctcctaattg      420

gattatatat gagaagagct gttatctatt cagcatgtca ctaaattcct gggatggaag      480

taaaagacaa tgctggcaac tgggctctaa tctcctaaag atagacagct caaatgaatt      540

gggatttata gtaaaacaag tgtcttccca acctgataat tcattttgga taggcctttc      600

tcggccccag actgaggtac catggctctg ggaggatgga tcaacattct cttctaactt      660

atttcagatc agaaccacag ctacccaaga aaacccatct ccaaattgtg tatggattca      720

cgtgtcagtc atttatgacc aactgtgtag tgtgccctca tatagtattt gtgagaagaa      780

gttttcaatg taagaggaag ggtggagaag gagagagaaa tatgtgaggt agtaaggagg      840

acagaaaaca gaacagaaaa gagtaacagc tgaggtcaag ataaatgcag aaaatgttta      900

gagagcttgg ccaactgtaa tcttaaccaa gaaattgaag ggagaggctg tgatttctgt      960

atttgtcgac ctacaggtag gctagtatta tttttctagt tagtagatcc ctagacatgg     1020

aatcagggca gccaagcttg agtttttatt ttttatttat ttattttttt gagatagggt     1080

ctcactttgt tacccaggct ggagtgcagt ggcacaatct cgactcactg cagctatctc     1140

tcgcctcagc ccctcaagta gctgggacta caggtgcatg ccaccatgcc aggctaattt     1200

ttggtgtttt ttgtagagac tgggttttgc catgttgacc aagctggtct ctaactcctg     1260

ggcttaagtg atctgcccgc cttggcctcc caaagtgctg ggattacaga tgtgagccac     1320

cacacctggc cccaagcttg aattttcatt ctgccattga cttggcattt accttgggta     1380

agccataagc gaatcttaat ttctggctct atcagagttg tttcatgctc aacaatgcca     1440

ttgaagtgca cggtgtgttg ccacgatttg accctcaact tctagcagta tatcagttat     1500

gaactgaggg tgaaatatat ttctgaatag ctaaatgaag aaatgggaaa aaatcttcac     1560

cacagtcaga gcaattttat tattttcatc agtatgatca taattatgat tatcatctta     1620

gtaaaaagca ggaactccta ctttttcttt atcaattaaa tagctcagag agtacatctg     1680

ccatatctct aatagaatct tttttttttt tttttttttt gagacagagt ttcgctcttg     1740

ttgcccaggc tggagtgcaa cggcacgatc tcggctcacc gcaacctccg ccccctgggt     1800

tcaagcaatt ctcctgcctc agcctcccaa gtagctggga ttacagtcag gcaccaccac     1860

acccggctaa ttttgtattt ttttagtaga gacagggttt ctccatgtcg gtcagggtag     1920

tcccgaactc ctgacctcaa gtgatctgcc tgcctcggcc tcccaagtgc tgggattaca     1980

ggcgtgagcc actgcaccca gcctagaatc ttgtataata tgtaattgta gggaaactgc     2040

tctcatagga aagttttctg ctttttaaat acaaaaatac ataaaaatac ataaaatctg     2100

atgatgaata taaaaaagta accaacctca ttggaacaag tattaacatt ttggaatatg     2160

ttttattagt tttgtgatgt actgttttac aatttttacc atttttttca gtaattactg     2220

taaaatggta ttattggaat gaaactatat ttcctcatgt gctgatttgt cttatttttt     2280

tcatactttc ccactggtgc tatttttatt tccaatggat atttctgtat tactagggag     2340

gcatttacag tcctctaatg ttgattaata tgtgaaaaga aattgtacca attttactaa     2400

attatgcagt ttaaaatgga tgattttatg ttatgtggat ttcatttcaa taaaaaaaaa     2460

ctcttatcaa aaaaaaaaaa aaaa                                            2484


<210> 130
<211> 201
<212> PRT
<213> Homo sapiens

<400> 130
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Thr 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Thr Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Thr Met Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile 
65                  70                  75                  80  


Tyr Glu Lys Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp 
                85                  90                  95      


Gly Ser Lys Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile 
            100                 105                 110         


Asp Ser Ser Asn Glu Leu Gly Phe Ile Val Lys Gln Val Ser Ser Gln 
        115                 120                 125             


Pro Asp Asn Ser Phe Trp Ile Gly Leu Ser Arg Pro Gln Thr Glu Val 
    130                 135                 140                 


Pro Trp Leu Trp Glu Asp Gly Ser Thr Phe Ser Ser Asn Leu Phe Gln 
145                 150                 155                 160 


Ile Arg Thr Thr Ala Thr Gln Glu Asn Pro Ser Pro Asn Cys Val Trp 
                165                 170                 175     


Ile His Val Ser Val Ile Tyr Asp Gln Leu Cys Ser Val Pro Ser Tyr 
            180                 185                 190         


Ser Ile Cys Glu Lys Lys Phe Ser Met 
        195                 200     


<210> 131
<211> 2503
<212> DNA
<213> Homo sapiens

<400> 131
agcatagttt catttcctgc tcttgaatat ctggttgaac tacttaagct taatttgtta       60

aactccggta agtacctagc ccacatgatt tgactcagag attctctttt gtccacagac      120

agtcatctca ggagcagaaa gaaaagagct cccaaatgct atatctattc aggggctctc      180

aagaacaatg gaatatcatc ctgatttaga aaatttggat gaagatggat atactcaatt      240

acacttcgac tctcaaagca ataccaggat agctgttgtt tcagagaaag gatcgtgtgc      300

tgcatctcct ccttggcgcc tcattgctgt aattttggga atcctatgct tggtaatact      360

ggtgatagct gtggtcctgg gtaccatggc tatttggaga tccaattcag gaagcaacac      420

attggagaat ggctactttc tatcaagaaa taaagagaac cacagtcaac ccacacaatc      480

atctttagaa gacagtgtga ctcctaccaa agctgtcaaa accacagggg ttctttccag      540

cccttgtcct cctaattgga ttatatatga gaagagctgt tatctattca gcatgtcact      600

aaattcctgg gatggaagta aaagacaatg ctggcaactg ggctctaatc tcctaaagat      660

agacagctca aatgaattga tttcagatca gaaccacagc tacccaagaa aacccatctc      720

caaattgtgt atggattcac gtgtcagtca tttatgacca actgtgtagt gtgccctcat      780

atagtatttg tgagaagaag ttttcaatgt aagaggaagg gtggagaagg agagagaaat      840

atgtgaggta gtaaggagga cagaaaacag aacagaaaag agtaacagct gaggtcaaga      900

taaatgcaga aaatgtttag agagcttggc caactgtaat cttaaccaag aaattgaagg      960

gagaggctgt gatttctgta tttgtcgacc tacaggtagg ctagtattat ttttctagtt     1020

agtagatccc tagacatgga atcagggcag ccaagcttga gtttttattt tttatttatt     1080

tatttttttg agatagggtc tcactttgtt acccaggctg gagtgcagtg gcacaatctc     1140

gactcactgc agctatctct cgcctcagcc cctcaagtag ctgggactac aggtgcatgc     1200

caccatgcca ggctaatttt tggtgttttt tgtagagact gggttttgcc atgttgacca     1260

agctggtctc taactcctgg gcttaagtga tctgcccgcc ttggcctccc aaagtgctgg     1320

gattacagat gtgagccacc acacctggcc ccaagcttga attttcattc tgccattgac     1380

ttggcattta ccttgggtaa gccataagcg aatcttaatt tctggctcta tcagagttgt     1440

ttcatgctca acaatgccat tgaagtgcac ggtgtgttgc cacgatttga ccctcaactt     1500

ctagcagtat atcagttatg aactgagggt gaaatatatt tctgaatagc taaatgaaga     1560

aatgggaaaa aatcttcacc acagtcagag caattttatt attttcatca gtatgatcat     1620

aattatgatt atcatcttag taaaaagcag gaactcctac tttttcttta tcaattaaat     1680

agctcagaga gtacatctgc catatctcta atagaatctt tttttttttt tttttttttg     1740

agacagagtt tcgctcttgt tgcccaggct ggagtgcaac ggcacgatct cggctcaccg     1800

caacctccgc cccctgggtt caagcaattc tcctgcctca gcctcccaag tagctgggat     1860

tacagtcagg caccaccaca cccggctaat tttgtatttt tttagtagag acagggtttc     1920

tccatgtcgg tcagggtagt cccgaactcc tgacctcaag tgatctgcct gcctcggcct     1980

cccaagtgct gggattacag gcgtgagcca ctgcacccag cctagaatct tgtataatat     2040

gtaattgtag ggaaactgct ctcataggaa agttttctgc tttttaaata caaaaataca     2100

taaaaataca taaaatctga tgatgaatat aaaaaagtaa ccaacctcat tggaacaagt     2160

attaacattt tggaatatgt tttattagtt ttgtgatgta ctgttttaca atttttacca     2220

tttttttcag taattactgt aaaatggtat tattggaatg aaactatatt tcctcatgtg     2280

ctgatttgtc ttattttttt catactttcc cactggtgct atttttattt ccaatggata     2340

tttctgtatt actagggagg catttacagt cctctaatgt tgattaatat gtgaaaagaa     2400

attgtaccaa ttttactaaa ttatgcagtt taaaatggat gattttatgt tatgtggatt     2460

tcatttcaat aaaaaaaaac tcttatcaaa aaaaaaaaaa aaa                       2503


<210> 132
<211> 189
<212> PRT
<213> Homo sapiens

<400> 132
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Thr 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Thr Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Thr Met Ala Ile Trp Arg Ser Asn Ser Gly Ser Asn Thr Leu Glu 
65                  70                  75                  80  


Asn Gly Tyr Phe Leu Ser Arg Asn Lys Glu Asn His Ser Gln Pro Thr 
                85                  90                  95      


Gln Ser Ser Leu Glu Asp Ser Val Thr Pro Thr Lys Ala Val Lys Thr 
            100                 105                 110         


Thr Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile Tyr Glu 
        115                 120                 125             


Lys Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp Gly Ser 
    130                 135                 140                 


Lys Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile Asp Ser 
145                 150                 155                 160 


Ser Asn Glu Leu Ile Ser Asp Gln Asn His Ser Tyr Pro Arg Lys Pro 
                165                 170                 175     


Ile Ser Lys Leu Cys Met Asp Ser Arg Val Ser His Leu 
            180                 185                 


<210> 133
<211> 2365
<212> DNA
<213> Homo sapiens

<400> 133
agcatagttt catttcctgc tcttgaatat ctggttgaac tacttaagct taatttgtta       60

aactccggta agtacctagc ccacatgatt tgactcagag attctctttt gtccacagac      120

agtcatctca ggagcagaaa gaaaagagct cccaaatgct atatctattc aggggctctc      180

aagaacaatg gaatatcatc ctgatttaga aaatttggat gaagatggat atactcaatt      240

acacttcgac tctcaaagca ataccaggat agctgttgtt tcagagaaag gatcgtgtgc      300

tgcatctcct ccttggcgcc tcattgctgt aattttggga atcctatgct tggtaatact      360

ggtgatagct gtggtcctgg gtaccatggg ggttctttcc agcccttgtc ctcctaattg      420

gattatatat gagaagagct gttatctatt cagcatgtca ctaaattcct gggatggaag      480

taaaagacaa tgctggcaac tgggctctaa tctcctaaag atagacagct caaatgaatt      540

gatttcagat cagaaccaca gctacccaag aaaacccatc tccaaattgt gtatggattc      600

acgtgtcagt catttatgac caactgtgta gtgtgccctc atatagtatt tgtgagaaga      660

agttttcaat gtaagaggaa gggtggagaa ggagagagaa atatgtgagg tagtaaggag      720

gacagaaaac agaacagaaa agagtaacag ctgaggtcaa gataaatgca gaaaatgttt      780

agagagcttg gccaactgta atcttaacca agaaattgaa gggagaggct gtgatttctg      840

tatttgtcga cctacaggta ggctagtatt atttttctag ttagtagatc cctagacatg      900

gaatcagggc agccaagctt gagtttttat tttttattta tttatttttt tgagataggg      960

tctcactttg ttacccaggc tggagtgcag tggcacaatc tcgactcact gcagctatct     1020

ctcgcctcag cccctcaagt agctgggact acaggtgcat gccaccatgc caggctaatt     1080

tttggtgttt tttgtagaga ctgggttttg ccatgttgac caagctggtc tctaactcct     1140

gggcttaagt gatctgcccg ccttggcctc ccaaagtgct gggattacag atgtgagcca     1200

ccacacctgg ccccaagctt gaattttcat tctgccattg acttggcatt taccttgggt     1260

aagccataag cgaatcttaa tttctggctc tatcagagtt gtttcatgct caacaatgcc     1320

attgaagtgc acggtgtgtt gccacgattt gaccctcaac ttctagcagt atatcagtta     1380

tgaactgagg gtgaaatata tttctgaata gctaaatgaa gaaatgggaa aaaatcttca     1440

ccacagtcag agcaatttta ttattttcat cagtatgatc ataattatga ttatcatctt     1500

agtaaaaagc aggaactcct actttttctt tatcaattaa atagctcaga gagtacatct     1560

gccatatctc taatagaatc tttttttttt tttttttttt tgagacagag tttcgctctt     1620

gttgcccagg ctggagtgca acggcacgat ctcggctcac cgcaacctcc gccccctggg     1680

ttcaagcaat tctcctgcct cagcctccca agtagctggg attacagtca ggcaccacca     1740

cacccggcta attttgtatt tttttagtag agacagggtt tctccatgtc ggtcagggta     1800

gtcccgaact cctgacctca agtgatctgc ctgcctcggc ctcccaagtg ctgggattac     1860

aggcgtgagc cactgcaccc agcctagaat cttgtataat atgtaattgt agggaaactg     1920

ctctcatagg aaagttttct gctttttaaa tacaaaaata cataaaaata cataaaatct     1980

gatgatgaat ataaaaaagt aaccaacctc attggaacaa gtattaacat tttggaatat     2040

gttttattag ttttgtgatg tactgtttta caatttttac catttttttc agtaattact     2100

gtaaaatggt attattggaa tgaaactata tttcctcatg tgctgatttg tcttattttt     2160

ttcatacttt cccactggtg ctatttttat ttccaatgga tatttctgta ttactaggga     2220

ggcatttaca gtcctctaat gttgattaat atgtgaaaag aaattgtacc aattttacta     2280

aattatgcag tttaaaatgg atgattttat gttatgtgga tttcatttca ataaaaaaaa     2340

actcttatca aaaaaaaaaa aaaaa                                           2365


<210> 134
<211> 143
<212> PRT
<213> Homo sapiens

<400> 134
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Thr 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Thr Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Thr Met Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile 
65                  70                  75                  80  


Tyr Glu Lys Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp 
                85                  90                  95      


Gly Ser Lys Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile 
            100                 105                 110         


Asp Ser Ser Asn Glu Leu Ile Ser Asp Gln Asn His Ser Tyr Pro Arg 
        115                 120                 125             


Lys Pro Ile Ser Lys Leu Cys Met Asp Ser Arg Val Ser His Leu 
    130                 135                 140             


<210> 135
<211> 2385
<212> DNA
<213> Homo sapiens

<400> 135
agcatagttt catttcctgc tcttgaatat ctggttgaac tacttaagct taatttgtta       60

aactccggta agtacctagc ccacatgatt tgactcagag attctctttt gtccacagac      120

agtcatctca ggagcagaaa gaaaagagct cccaaatgct atatctattc aggggctctc      180

aagaacaatg gaatatcatc ctgatttaga aaatttggat gaagatggat atactcaatt      240

acacttcgac tctcaaagca ataccaggat agctgttgtt tcagagaaag gggttctttc      300

cagcccttgt cctcctaatt ggattatata tgagaagagc tgttatctat tcagcatgtc      360

actaaattcc tgggatggaa gtaaaagaca atgctggcaa ctgggctcta atctcctaaa      420

gatagacagc tcaaatgaat tgggatttat agtaaaacaa gtgtcttccc aacctgataa      480

ttcattttgg ataggccttt ctcggcccca gactgaggta ccatggctct gggaggatgg      540

atcaacattc tcttctaact tatttcagat cagaaccaca gctacccaag aaaacccatc      600

tccaaattgt gtatggattc acgtgtcagt catttatgac caactgtgta gtgtgccctc      660

atatagtatt tgtgagaaga agttttcaat gtaagaggaa gggtggagaa ggagagagaa      720

atatgtgagg tagtaaggag gacagaaaac agaacagaaa agagtaacag ctgaggtcaa      780

gataaatgca gaaaatgttt agagagcttg gccaactgta atcttaacca agaaattgaa      840

gggagaggct gtgatttctg tatttgtcga cctacaggta ggctagtatt atttttctag      900

ttagtagatc cctagacatg gaatcagggc agccaagctt gagtttttat tttttattta      960

tttatttttt tgagataggg tctcactttg ttacccaggc tggagtgcag tggcacaatc     1020

tcgactcact gcagctatct ctcgcctcag cccctcaagt agctgggact acaggtgcat     1080

gccaccatgc caggctaatt tttggtgttt tttgtagaga ctgggttttg ccatgttgac     1140

caagctggtc tctaactcct gggcttaagt gatctgcccg ccttggcctc ccaaagtgct     1200

gggattacag atgtgagcca ccacacctgg ccccaagctt gaattttcat tctgccattg     1260

acttggcatt taccttgggt aagccataag cgaatcttaa tttctggctc tatcagagtt     1320

gtttcatgct caacaatgcc attgaagtgc acggtgtgtt gccacgattt gaccctcaac     1380

ttctagcagt atatcagtta tgaactgagg gtgaaatata tttctgaata gctaaatgaa     1440

gaaatgggaa aaaatcttca ccacagtcag agcaatttta ttattttcat cagtatgatc     1500

ataattatga ttatcatctt agtaaaaagc aggaactcct actttttctt tatcaattaa     1560

atagctcaga gagtacatct gccatatctc taatagaatc tttttttttt tttttttttt     1620

tgagacagag tttcgctctt gttgcccagg ctggagtgca acggcacgat ctcggctcac     1680

cgcaacctcc gccccctggg ttcaagcaat tctcctgcct cagcctccca agtagctggg     1740

attacagtca ggcaccacca cacccggcta attttgtatt tttttagtag agacagggtt     1800

tctccatgtc ggtcagggta gtcccgaact cctgacctca agtgatctgc ctgcctcggc     1860

ctcccaagtg ctgggattac aggcgtgagc cactgcaccc agcctagaat cttgtataat     1920

atgtaattgt agggaaactg ctctcatagg aaagttttct gctttttaaa tacaaaaata     1980

cataaaaata cataaaatct gatgatgaat ataaaaaagt aaccaacctc attggaacaa     2040

gtattaacat tttggaatat gttttattag ttttgtgatg tactgtttta caatttttac     2100

catttttttc agtaattact gtaaaatggt attattggaa tgaaactata tttcctcatg     2160

tgctgatttg tcttattttt ttcatacttt cccactggtg ctatttttat ttccaatgga     2220

tatttctgta ttactaggga ggcatttaca gtcctctaat gttgattaat atgtgaaaag     2280

aaattgtacc aattttacta aattatgcag tttaaaatgg atgattttat gttatgtgga     2340

tttcatttca ataaaaaaaa actcttatca aaaaaaaaaa aaaaa                     2385


<210> 136
<211> 168
<212> PRT
<213> Homo sapiens

<400> 136
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Thr 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Thr Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile Tyr 
        35                  40                  45              


Glu Lys Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp Gly 
    50                  55                  60                  


Ser Lys Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile Asp 
65                  70                  75                  80  


Ser Ser Asn Glu Leu Gly Phe Ile Val Lys Gln Val Ser Ser Gln Pro 
                85                  90                  95      


Asp Asn Ser Phe Trp Ile Gly Leu Ser Arg Pro Gln Thr Glu Val Pro 
            100                 105                 110         


Trp Leu Trp Glu Asp Gly Ser Thr Phe Ser Ser Asn Leu Phe Gln Ile 
        115                 120                 125             


Arg Thr Thr Ala Thr Gln Glu Asn Pro Ser Pro Asn Cys Val Trp Ile 
    130                 135                 140                 


His Val Ser Val Ile Tyr Asp Gln Leu Cys Ser Val Pro Ser Tyr Ser 
145                 150                 155                 160 


Ile Cys Glu Lys Lys Phe Ser Met 
                165             


<210> 137
<211> 519
<212> DNA
<213> Homo sapiens

<400> 137
agcatagttt catttcctgc tcttgaatat ctggttgaac tacttaagct taatttgtta       60

aactccggta agtacctagc ccacatgatt tgactcagag attctctttt gtccacagac      120

agtcatctca ggagcagaaa gaaaagagct cccaaatgct atatctattc aggggctctc      180

aagaacaatg gaatatcatc ctgatttaga aaatttggat gaagatggat atactcaatt      240

acacttcgac tctcaaagca ataccaggat agctgttgtt tcagagaaag gatcgtgtgc      300

tgcatctcct ccttggcgcc tcattgctgt aattttggga atcctatgct tggtaatact      360

ggtgatagct gtggtcctgg gtaccatggc tggtttcaaa gctgtggaat tcaaaggata      420

aattaatgaa gaaaacaagc ggagctgaag aagaaagtac aatatggtgc tgtcttccta      480

atgaaataaa ttcactaaat ggacattaaa aaaaaaaaa                             519


<210> 138
<211> 77
<212> PRT
<213> Homo sapiens

<400> 138
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Thr 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Thr Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Thr Met Ala Gly Phe Lys Ala Val Glu Phe Lys Gly 
65                  70                  75          


<210> 139
<211> 2144
<212> DNA
<213> Mus musculus

<400> 139
tgtttcaggg tttgggttag tgagcctcat cctggcagtt attttatagt aaagaacatt       60

caagtgctct gcctacctag ggccctgtga agcaatgaaa tatcactctc atatagagaa      120

tctggatgaa gatggatata ctcaattaga cttcagcact caagacatcc ataaaaggcc      180

caggggatca gagaaaggaa gccaggctcc atcttcacct tggaggccca ttgcagtggg      240

tttaggaatc ctgtgctttg tggtagtagt ggttgctgca gtgctgggtg ccctaggagg      300

tttttctcag ccttgccttc ctaattggat catgcatggg aagagctgtt acctatttag      360

cttctcagga aattcctggt atggaagtaa gagacactgc tcccagctag gtgctcatct      420

actgaagata gacaactcaa aagaatttga gttcattgaa agccaaacat cgtctcaccg      480

tattaatgca ttttggatag gcctttcccg caatcagagt gaagggccat ggttctggga      540

ggatggatca gcattcttcc ccaactcgtt tcaagtcaga aatacagctc cccaggaaag      600

cttactgcac aattgtgtat ggattcatgg atcagaggtc tacaaccaaa tctgcaatac      660

ttcttcatac agtatctgtg agaaggaact gtaaatgtat gtgagaatat aaagatggtg      720

tgtgtgtgtg tgtgtgtgtg tgtgtacatg cacacacacc accaccacca ccactaccaa      780

caacagaaca gaacagaaca gaacagaaca gattaatatt aaaaaacaga aaaaatgctg      840

ggatgctaag agactttaac ctcatttgag aacttggatg aagaagctga gacttttgta      900

cttgtcatct tcacaaagat ggtggcacta tcttccagtt aggaagtcac tagacatgga      960

gtgagggcag ctcaacaata cagagaatat gtgaacctga ggtaccctga ctcaaatttc     1020

acaaccacaa tgaaacccct acactatcag gaaacactgt agaggagtga gactgaagac     1080

tttaaaagcc agagaatcag cctacttact gtggtgtttt ctagacagga cagggaaagt     1140

atatctagga aataaaaaca atacaattca gcaaacaaaa tctgcataat gacaacctca     1200

gttggtatgg tatgttatgg tatggtatgg gtgtagaagt ttcacaaggc cctatgaaga     1260

actacagaca gttaaatagg gggaaagctt tttctaggat caagcctact gaaccccaag     1320

aagtcagcac tgaacatatg tacagatcag tatcattaaa tgaactagta agacatatac     1380

atatatgtta atcaaatatt ggtaccagag tacacactgt gtttgcatga ttttctcagt     1440

atctacagta caccagacac agggagaagg caaaatgaac ttctaaattg agaagtgaaa     1500

aaaatgaggg aagagaatct tcaccacaaa tagggattct attttcaccc acatgatcat     1560

tattaagatg gccatcaccc aaacgtcgtg acccaagcta cttcctcaac tagataactc     1620

aaagagtctg cccacctttt ctgatagcaa atctggtatc tagatttcac tgtttcctta     1680

tgctgtctgg ccagcagtat gacaaaggtg ctgccctttc aggaagcagt ctccttaaat     1740

gctgtagttg gaaagataaa tcatatctga tagtgaatat ttaaaaagcg cccagtcagg     1800

ataagtgttt tggaacacag aacatatttc atctttttat gatacactat cttgcaatta     1860

acaaccaatt cttaagtcat ttctttacaa acatatgact ggaatatgac tgtttcctag     1920

tgtgatctgt cttgttaact tctaagattg tccattaata ccacccttat ttccagtgtg     1980

gacttccaaa ttgctgggga tctgtttata gctttctcag actaatcaat atgtgggcag     2040

aaattgtgct gagtccactg aattgttctc ttgaaaatga ttgggtttat gtcactttca     2100

tctcaattga aaaactgctt attaaagtat ctttggcctc tgaa                      2144


<210> 140
<211> 199
<212> PRT
<213> Mus musculus

<400> 140
Met Lys Tyr His Ser His Ile Glu Asn Leu Asp Glu Asp Gly Tyr Thr 
1               5                   10                  15      


Gln Leu Asp Phe Ser Thr Gln Asp Ile His Lys Arg Pro Arg Gly Ser 
            20                  25                  30          


Glu Lys Gly Ser Gln Ala Pro Ser Ser Pro Trp Arg Pro Ile Ala Val 
        35                  40                  45              


Gly Leu Gly Ile Leu Cys Phe Val Val Val Val Val Ala Ala Val Leu 
    50                  55                  60                  


Gly Ala Leu Gly Gly Phe Ser Gln Pro Cys Leu Pro Asn Trp Ile Met 
65                  70                  75                  80  


His Gly Lys Ser Cys Tyr Leu Phe Ser Phe Ser Gly Asn Ser Trp Tyr 
                85                  90                  95      


Gly Ser Lys Arg His Cys Ser Gln Leu Gly Ala His Leu Leu Lys Ile 
            100                 105                 110         


Asp Asn Ser Lys Glu Phe Glu Phe Ile Glu Ser Gln Thr Ser Ser His 
        115                 120                 125             


Arg Ile Asn Ala Phe Trp Ile Gly Leu Ser Arg Asn Gln Ser Glu Gly 
    130                 135                 140                 


Pro Trp Phe Trp Glu Asp Gly Ser Ala Phe Phe Pro Asn Ser Phe Gln 
145                 150                 155                 160 


Val Arg Asn Thr Ala Pro Gln Glu Ser Leu Leu His Asn Cys Val Trp 
                165                 170                 175     


Ile His Gly Ser Glu Val Tyr Asn Gln Ile Cys Asn Thr Ser Ser Tyr 
            180                 185                 190         


Ser Ile Cys Glu Lys Glu Leu 
        195                 


<210> 141
<211> 2279
<212> DNA
<213> Mus musculus

<400> 141
tgtttcaggg tttgggttag tgagcctcat cctggcagtt attttatagt aaagaacatt       60

caagtgctct gcctacctag ggccctgtga agcaatgaaa tatcactctc atatagagaa      120

tctggatgaa gatggatata ctcaattaga cttcagcact caagacatcc ataaaaggcc      180

caggggatca gagaaaggaa gccaggctcc atcttcacct tggaggccca ttgcagtggg      240

tttaggaatc ctgtgctttg tggtagtagt ggttgctgca gtgctgggtg ccctagcatt      300

ttggcgacac aattcaggga gaaatccaga ggagaaagac aacttcctat caagaaataa      360

agagaaccac aagcccacag aatcatcttt agatgagaag gtggctccct ccaaggcatc      420

ccaaactaca ggaggttttt ctcagccttg ccttcctaat tggatcatgc atgggaagag      480

ctgttaccta tttagcttct caggaaattc ctggtatgga agtaagagac actgctccca      540

gctaggtgct catctactga agatagacaa ctcaaaagaa tttgagttca ttgaaagcca      600

aacatcgtct caccgtatta atgcattttg gataggcctt tcccgcaatc agagtgaagg      660

gccatggttc tgggaggatg gatcagcatt cttccccaac tcgtttcaag tcagaaatac      720

agctccccag gaaagcttac tgcacaattg tgtatggatt catggatcag aggtctacaa      780

ccaaatctgc aatacttctt catacagtat ctgtgagaag gaactgtaaa tgtatgtgag      840

aatataaaga tggtgtgtgt gtgtgtgtgt gtgtgtgtgt acatgcacac acaccaccac      900

caccaccact accaacaaca gaacagaaca gaacagaaca gaacagatta atattaaaaa      960

acagaaaaaa tgctgggatg ctaagagact ttaacctcat ttgagaactt ggatgaagaa     1020

gctgagactt ttgtacttgt catcttcaca aagatggtgg cactatcttc cagttaggaa     1080

gtcactagac atggagtgag ggcagctcaa caatacagag aatatgtgaa cctgaggtac     1140

cctgactcaa atttcacaac cacaatgaaa cccctacact atcaggaaac actgtagagg     1200

agtgagactg aagactttaa aagccagaga atcagcctac ttactgtggt gttttctaga     1260

caggacaggg aaagtatatc taggaaataa aaacaataca attcagcaaa caaaatctgc     1320

ataatgacaa cctcagttgg tatggtatgt tatggtatgg tatgggtgta gaagtttcac     1380

aaggccctat gaagaactac agacagttaa atagggggaa agctttttct aggatcaagc     1440

ctactgaacc ccaagaagtc agcactgaac atatgtacag atcagtatca ttaaatgaac     1500

tagtaagaca tatacatata tgttaatcaa atattggtac cagagtacac actgtgtttg     1560

catgattttc tcagtatcta cagtacacca gacacaggga gaaggcaaaa tgaacttcta     1620

aattgagaag tgaaaaaaat gagggaagag aatcttcacc acaaataggg attctatttt     1680

cacccacatg atcattatta agatggccat cacccaaacg tcgtgaccca agctacttcc     1740

tcaactagat aactcaaaga gtctgcccac cttttctgat agcaaatctg gtatctagat     1800

ttcactgttt ccttatgctg tctggccagc agtatgacaa aggtgctgcc ctttcaggaa     1860

gcagtctcct taaatgctgt agttggaaag ataaatcata tctgatagtg aatatttaaa     1920

aagcgcccag tcaggataag tgttttggaa cacagaacat atttcatctt tttatgatac     1980

actatcttgc aattaacaac caattcttaa gtcatttctt tacaaacata tgactggaat     2040

atgactgttt cctagtgtga tctgtcttgt taacttctaa gattgtccat taataccacc     2100

cttatttcca gtgtggactt ccaaattgct ggggatctgt ttatagcttt ctcagactaa     2160

tcaatatgtg ggcagaaatt gtgctgagtc cactgaattg ttctcttgaa aatgattggg     2220

tttatgtcac tttcatctca attgaaaaac tgcttattaa agtatctttg gcctctgaa      2279


<210> 142
<211> 244
<212> PRT
<213> Mus musculus

<400> 142
Met Lys Tyr His Ser His Ile Glu Asn Leu Asp Glu Asp Gly Tyr Thr 
1               5                   10                  15      


Gln Leu Asp Phe Ser Thr Gln Asp Ile His Lys Arg Pro Arg Gly Ser 
            20                  25                  30          


Glu Lys Gly Ser Gln Ala Pro Ser Ser Pro Trp Arg Pro Ile Ala Val 
        35                  40                  45              


Gly Leu Gly Ile Leu Cys Phe Val Val Val Val Val Ala Ala Val Leu 
    50                  55                  60                  


Gly Ala Leu Ala Phe Trp Arg His Asn Ser Gly Arg Asn Pro Glu Glu 
65                  70                  75                  80  


Lys Asp Asn Phe Leu Ser Arg Asn Lys Glu Asn His Lys Pro Thr Glu 
                85                  90                  95      


Ser Ser Leu Asp Glu Lys Val Ala Pro Ser Lys Ala Ser Gln Thr Thr 
            100                 105                 110         


Gly Gly Phe Ser Gln Pro Cys Leu Pro Asn Trp Ile Met His Gly Lys 
        115                 120                 125             


Ser Cys Tyr Leu Phe Ser Phe Ser Gly Asn Ser Trp Tyr Gly Ser Lys 
    130                 135                 140                 


Arg His Cys Ser Gln Leu Gly Ala His Leu Leu Lys Ile Asp Asn Ser 
145                 150                 155                 160 


Lys Glu Phe Glu Phe Ile Glu Ser Gln Thr Ser Ser His Arg Ile Asn 
                165                 170                 175     


Ala Phe Trp Ile Gly Leu Ser Arg Asn Gln Ser Glu Gly Pro Trp Phe 
            180                 185                 190         


Trp Glu Asp Gly Ser Ala Phe Phe Pro Asn Ser Phe Gln Val Arg Asn 
        195                 200                 205             


Thr Ala Pro Gln Glu Ser Leu Leu His Asn Cys Val Trp Ile His Gly 
    210                 215                 220                 


Ser Glu Val Tyr Asn Gln Ile Cys Asn Thr Ser Ser Tyr Ser Ile Cys 
225                 230                 235                 240 


Glu Lys Glu Leu 
                


<210> 143
<211> 2082
<212> DNA
<213> Homo sapiens

<400> 143
aaggaataaa gttgctgatt cattccttta cactgaaacc ctttgttgtg ccctcctctt       60

ccttcctctt tatagggaga cactctgaga aagagcacat tgtgggggcc cactccatgt      120

gatgtttgct tggttgcctg ttcccttttc tacctgcaga gcacggttcc cataagggcg      180

gcgagatcag cctcctgtct catctggaag accaccactc tggggtctca gaggaatgat      240

ggaagccttg gggtttctaa aattggaagt gaatggcccc atggtgacgg tggccctgtc      300

agtggctctc ttggccctcc tgaaatggta ctccacatca gcattctcaa gactggagaa      360

gttaggcctc agacatccca agccttctcc tttcattgga aacttgacat ttttccgcca      420

gggtttttgg gaaagccaaa tggagctcag aaagctgtat ggacctctgt gtgggtacta      480

tcttggtcgt cggatgttta ttgttatttc tgagccagac atgatcaagc aggtgttggt      540

tgagaacttc agtaacttta ccaacagaat ggcgtcgggt ttggagttca agtcggtagc      600

cgacagcgtt ctgtttttac gtgacaaaag atgggaagag gtcagaggtg ccctgatgtc      660

tgctttcagt cctgaaaagc tgaacgagat ggttcccctc atcagccaag cctgcgacct      720

tctcctggct catttaaaac gctatgcgga atctggggac gcatttgaca tccagaggtg      780

ctactgcaat tacaccacag atgtggttgc cagcgtcgcc tttggcaccc cggtggactc      840

ctggcaggcc cctgaggatc cctttgtgaa acactgcaag cgtttcttcg aattctgcat      900

ccccagacct atcctggttt tactcttatc atttccatcc ataatggtcc cactggcccg      960

gattttgccc aataagaacc gagacgaact gaatggcttt tttaacaaac tcattaggaa     1020

tgtgattgcc ttgcgggacc agcaagctgc cgaagagagg cggagagact tcctccaaat     1080

ggtcctggat gcccgacatt ctgcaagtcc catgggcgtg caagactttg acatcgtcag     1140

agacgttttc tcctctactg ggtgcaagcc gaacccttcc cggcaacacc agcccagccc     1200

tatggccagg cctttgactg tggatgagat tgtgggccag gccttcatct tcctcatcgc     1260

tggctatgaa atcatcacca acacactttc ttttgccacc tacctactgg ccaccaaccc     1320

tgactgccaa gagaagcttc tgagagaggt agacgttttt aaggagaaac acatggcccc     1380

tgagttctgc agcctcgagg aaggcctgcc ctatctggac atggtgattg cagagacgct     1440

gaggatgtac ccgccagctt tcagattcac acgggaggca gctcaggact gcgaggtgct     1500

ggggcagcgc atccccgcag gcgctgtgct agagatggcc gtgggtgccc tgcaccatga     1560

ccctgagcac tggccaagcc cggagacctt caaccctgaa aggttcacgg ctgaggcccg     1620

gcagcagcac cggcccttca cgtacctgcc cttcggggcc ggcccacgga gctgcctcgg     1680

ggtgcgtcta gggctgcttg aggtcaagtt gacactgctc cacgtgctgc acaagttccg     1740

gttccaagcc tgccctgaga cccaggtacc gctgcagcta gaatccaaat ctgccctagg     1800

tccaaaaaat ggtgtctata tcaagatcgt atcccgctga cacagaaggc tgccgggtgg     1860

ggggagggca cccccaaatt caaagaaaac cctaagtgtg gatgttcaga attttggaaa     1920

aatgtcactg aagtgattga aagagtgcct ggcatgcaag gataagaggt tctttacata     1980

acatttccta aatgcttaat aaacgtttgt tgcacttggt tttgacattg ccaatggggt     2040

ttgaaccagt gctctctcta aatgaaaaaa aaaaaaaaaa aa                        2082


<210> 144
<211> 534
<212> PRT
<213> Homo sapiens

<400> 144
Met Met Glu Ala Leu Gly Phe Leu Lys Leu Glu Val Asn Gly Pro Met 
1               5                   10                  15      


Val Thr Val Ala Leu Ser Val Ala Leu Leu Ala Leu Leu Lys Trp Tyr 
            20                  25                  30          


Ser Thr Ser Ala Phe Ser Arg Leu Glu Lys Leu Gly Leu Arg His Pro 
        35                  40                  45              


Lys Pro Ser Pro Phe Ile Gly Asn Leu Thr Phe Phe Arg Gln Gly Phe 
    50                  55                  60                  


Trp Glu Ser Gln Met Glu Leu Arg Lys Leu Tyr Gly Pro Leu Cys Gly 
65                  70                  75                  80  


Tyr Tyr Leu Gly Arg Arg Met Phe Ile Val Ile Ser Glu Pro Asp Met 
                85                  90                  95      


Ile Lys Gln Val Leu Val Glu Asn Phe Ser Asn Phe Thr Asn Arg Met 
            100                 105                 110         


Ala Ser Gly Leu Glu Phe Lys Ser Val Ala Asp Ser Val Leu Phe Leu 
        115                 120                 125             


Arg Asp Lys Arg Trp Glu Glu Val Arg Gly Ala Leu Met Ser Ala Phe 
    130                 135                 140                 


Ser Pro Glu Lys Leu Asn Glu Met Val Pro Leu Ile Ser Gln Ala Cys 
145                 150                 155                 160 


Asp Leu Leu Leu Ala His Leu Lys Arg Tyr Ala Glu Ser Gly Asp Ala 
                165                 170                 175     


Phe Asp Ile Gln Arg Cys Tyr Cys Asn Tyr Thr Thr Asp Val Val Ala 
            180                 185                 190         


Ser Val Ala Phe Gly Thr Pro Val Asp Ser Trp Gln Ala Pro Glu Asp 
        195                 200                 205             


Pro Phe Val Lys His Cys Lys Arg Phe Phe Glu Phe Cys Ile Pro Arg 
    210                 215                 220                 


Pro Ile Leu Val Leu Leu Leu Ser Phe Pro Ser Ile Met Val Pro Leu 
225                 230                 235                 240 


Ala Arg Ile Leu Pro Asn Lys Asn Arg Asp Glu Leu Asn Gly Phe Phe 
                245                 250                 255     


Asn Lys Leu Ile Arg Asn Val Ile Ala Leu Arg Asp Gln Gln Ala Ala 
            260                 265                 270         


Glu Glu Arg Arg Arg Asp Phe Leu Gln Met Val Leu Asp Ala Arg His 
        275                 280                 285             


Ser Ala Ser Pro Met Gly Val Gln Asp Phe Asp Ile Val Arg Asp Val 
    290                 295                 300                 


Phe Ser Ser Thr Gly Cys Lys Pro Asn Pro Ser Arg Gln His Gln Pro 
305                 310                 315                 320 


Ser Pro Met Ala Arg Pro Leu Thr Val Asp Glu Ile Val Gly Gln Ala 
                325                 330                 335     


Phe Ile Phe Leu Ile Ala Gly Tyr Glu Ile Ile Thr Asn Thr Leu Ser 
            340                 345                 350         


Phe Ala Thr Tyr Leu Leu Ala Thr Asn Pro Asp Cys Gln Glu Lys Leu 
        355                 360                 365             


Leu Arg Glu Val Asp Val Phe Lys Glu Lys His Met Ala Pro Glu Phe 
    370                 375                 380                 


Cys Ser Leu Glu Glu Gly Leu Pro Tyr Leu Asp Met Val Ile Ala Glu 
385                 390                 395                 400 


Thr Leu Arg Met Tyr Pro Pro Ala Phe Arg Phe Thr Arg Glu Ala Ala 
                405                 410                 415     


Gln Asp Cys Glu Val Leu Gly Gln Arg Ile Pro Ala Gly Ala Val Leu 
            420                 425                 430         


Glu Met Ala Val Gly Ala Leu His His Asp Pro Glu His Trp Pro Ser 
        435                 440                 445             


Pro Glu Thr Phe Asn Pro Glu Arg Phe Thr Ala Glu Ala Arg Gln Gln 
    450                 455                 460                 


His Arg Pro Phe Thr Tyr Leu Pro Phe Gly Ala Gly Pro Arg Ser Cys 
465                 470                 475                 480 


Leu Gly Val Arg Leu Gly Leu Leu Glu Val Lys Leu Thr Leu Leu His 
                485                 490                 495     


Val Leu His Lys Phe Arg Phe Gln Ala Cys Pro Glu Thr Gln Val Pro 
            500                 505                 510         


Leu Gln Leu Glu Ser Lys Ser Ala Leu Gly Pro Lys Asn Gly Val Tyr 
        515                 520                 525             


Ile Lys Ile Val Ser Arg 
    530                 


<210> 145
<211> 1919
<212> DNA
<213> Homo sapiens

<400> 145
aaggaataaa gttgctgatt cattccttta cactgaaacc ctttgttgtg ccctcctctt       60

ccttcctctt tatagggaga cactctgaga aagagcacat tgtgggggcc cactccatgt      120

gatgtttgct tggttgcctg ttcccttttc tacctgcaga gcacggttcc cataagggcg      180

gcgagatcag cctcctgtct catctggaag accaccactc tggggtctca gaggaatgat      240

ggaagccttg gggtttctaa aattggaagt gaatggcccc atggtgacgg tggccctgtc      300

agtggctctc ttggccctcc tgaaatggta ctccacatca gcattctcaa gactggagaa      360

gttaggcctc agacatccca agccttctcc tttcattgga aacttgacat ttttccgcca      420

gggtttttgg gaaagccaaa tggagctcag aaagctgtat ggacctctgt gtgggtacta      480

tcttggtcgt cggatgttta ttgttatttc tgagccagac atgatcaagc aggtgttggt      540

tgagaacttc agtaacttta ccaacagaat ggcgtcgggt ttggagttca agtcggtagc      600

cgacagcgtt ctgtttttac gtgacaaaag atgggaagag gtcagaggtg ccctgatgtc      660

tgctttcagt cctgaaaagc tgaacgagat ggttcccctc atcagccaag cctgcgacct      720

tctcctggct catttaaaac gctatgcgga atctggggac gcatttgaca tccagaggtg      780

ctactgcaat tacaccacag atgtggttgc cagcgtcgcc tttggcaccc cggtggactc      840

ctggcaggcc cctgaggatc cctttgtgaa acactgcaag cgtttcttcg aattctgcat      900

ccccagacct atcctggttt tactcttatc atttccatcc ataatggtcc cactggcccg      960

gattttgccc aataagaacc gagacgaact gaatggcttt tttaacaaac tcattaggaa     1020

tgtgattgcc ttgcgggacc agcaagctgc cgaagagagg cggagagact tcctccaaat     1080

ggtcctggat gcccgacatt ctgcaagtcc catgggcgtg caagactttg acatcgtcag     1140

agacgttttc tcctctactg ggtgcaagcc gaacccttcc cggcaacacc agcccagccc     1200

tatggccagg cctttgactg tggatgagat tgtgggccag gccttcatct tcctcatcgc     1260

tggctatgaa atcatcacca acacactttc ttttgccacc tacctactgg ccaccaaccc     1320

tgactgccaa gagaagcttc tgagagaggt agacgttttt aaggagaaac acatggcccc     1380

tgagttctgc agcctcgagg aaggcctgcc ctatctggac atggtgattg cagagacgct     1440

gaggatgtac ccgccagctt tcagattcac acgggaggca gctcaggact gcgaggtgct     1500

ggggcagcgc atccccgcag gcgctgtgct agagatggcc gtgggtgccc tgcaccatga     1560

ccctgagcac tggccaagcc cggagacctt caaccctgaa aggtaccgct gcagctagaa     1620

tccaaatctg ccctaggtcc aaaaaatggt gtctatatca agatcgtatc ccgctgacac     1680

agaaggctgc cgggtggggg gagggcaccc ccaaattcaa agaaaaccct aagtgtggat     1740

gttcagaatt ttggaaaaat gtcactgaag tgattgaaag agtgcctggc atgcaaggat     1800

aagaggttct ttacataaca tttcctaaat gcttaataaa cgtttgttgc acttggtttt     1860

gacattgcca atggggtttg aaccagtgct ctctctaaat gaaaaaaaaa aaaaaaaaa      1919


<210> 146
<211> 460
<212> PRT
<213> Homo sapiens

<400> 146
Met Met Glu Ala Leu Gly Phe Leu Lys Leu Glu Val Asn Gly Pro Met 
1               5                   10                  15      


Val Thr Val Ala Leu Ser Val Ala Leu Leu Ala Leu Leu Lys Trp Tyr 
            20                  25                  30          


Ser Thr Ser Ala Phe Ser Arg Leu Glu Lys Leu Gly Leu Arg His Pro 
        35                  40                  45              


Lys Pro Ser Pro Phe Ile Gly Asn Leu Thr Phe Phe Arg Gln Gly Phe 
    50                  55                  60                  


Trp Glu Ser Gln Met Glu Leu Arg Lys Leu Tyr Gly Pro Leu Cys Gly 
65                  70                  75                  80  


Tyr Tyr Leu Gly Arg Arg Met Phe Ile Val Ile Ser Glu Pro Asp Met 
                85                  90                  95      


Ile Lys Gln Val Leu Val Glu Asn Phe Ser Asn Phe Thr Asn Arg Met 
            100                 105                 110         


Ala Ser Gly Leu Glu Phe Lys Ser Val Ala Asp Ser Val Leu Phe Leu 
        115                 120                 125             


Arg Asp Lys Arg Trp Glu Glu Val Arg Gly Ala Leu Met Ser Ala Phe 
    130                 135                 140                 


Ser Pro Glu Lys Leu Asn Glu Met Val Pro Leu Ile Ser Gln Ala Cys 
145                 150                 155                 160 


Asp Leu Leu Leu Ala His Leu Lys Arg Tyr Ala Glu Ser Gly Asp Ala 
                165                 170                 175     


Phe Asp Ile Gln Arg Cys Tyr Cys Asn Tyr Thr Thr Asp Val Val Ala 
            180                 185                 190         


Ser Val Ala Phe Gly Thr Pro Val Asp Ser Trp Gln Ala Pro Glu Asp 
        195                 200                 205             


Pro Phe Val Lys His Cys Lys Arg Phe Phe Glu Phe Cys Ile Pro Arg 
    210                 215                 220                 


Pro Ile Leu Val Leu Leu Leu Ser Phe Pro Ser Ile Met Val Pro Leu 
225                 230                 235                 240 


Ala Arg Ile Leu Pro Asn Lys Asn Arg Asp Glu Leu Asn Gly Phe Phe 
                245                 250                 255     


Asn Lys Leu Ile Arg Asn Val Ile Ala Leu Arg Asp Gln Gln Ala Ala 
            260                 265                 270         


Glu Glu Arg Arg Arg Asp Phe Leu Gln Met Val Leu Asp Ala Arg His 
        275                 280                 285             


Ser Ala Ser Pro Met Gly Val Gln Asp Phe Asp Ile Val Arg Asp Val 
    290                 295                 300                 


Phe Ser Ser Thr Gly Cys Lys Pro Asn Pro Ser Arg Gln His Gln Pro 
305                 310                 315                 320 


Ser Pro Met Ala Arg Pro Leu Thr Val Asp Glu Ile Val Gly Gln Ala 
                325                 330                 335     


Phe Ile Phe Leu Ile Ala Gly Tyr Glu Ile Ile Thr Asn Thr Leu Ser 
            340                 345                 350         


Phe Ala Thr Tyr Leu Leu Ala Thr Asn Pro Asp Cys Gln Glu Lys Leu 
        355                 360                 365             


Leu Arg Glu Val Asp Val Phe Lys Glu Lys His Met Ala Pro Glu Phe 
    370                 375                 380                 


Cys Ser Leu Glu Glu Gly Leu Pro Tyr Leu Asp Met Val Ile Ala Glu 
385                 390                 395                 400 


Thr Leu Arg Met Tyr Pro Pro Ala Phe Arg Phe Thr Arg Glu Ala Ala 
                405                 410                 415     


Gln Asp Cys Glu Val Leu Gly Gln Arg Ile Pro Ala Gly Ala Val Leu 
            420                 425                 430         


Glu Met Ala Val Gly Ala Leu His His Asp Pro Glu His Trp Pro Ser 
        435                 440                 445             


Pro Glu Thr Phe Asn Pro Glu Arg Tyr Arg Cys Ser 
    450                 455                 460 


<210> 147
<211> 2385
<212> DNA
<213> Homo sapiens

<400> 147
gagggccggc ctggacccgg cgggcgcacg gctccgagcc cagcgcagcc gagccggtct       60

gcagaggggc ccccagaact ttgtgtgtgt gtgtgcacgc gcgcgcgtgt gtgcccaggt      120

gcgagggttc gcgcgtgtgc tggcggggag ggaaccgacc cgaaagagag ccccacgctg      180

gcaaagtggc tcgcccatct cacagccggt tggcgctcgc ggaggctcac agaacatttc      240

ctgcctgttg ctcacactct gttgtccaca gcatacccgc accctagatg gctgactctt      300

gtcttctgtc tctttatttt ccatgtgtga gcctgtgcct gtggtttatc tctggaggat      360

gtgcctgagg gaggagacat atactgcctg gactgcctgg ctgatgtgag ctagtttgtc      420

tggttgagtt ggatgtttaa atagaaggca gaacaacaac agagcacggt tcccataagg      480

gcggcgagat cagcctcctg tctcatctgg aagaccacca ctctggggtc tcagaggaat      540

gatggaagcc ttggggtttc taaaattgga agtgaatggc cccatggtga cggtggccct      600

gtcagtggct ctcttggccc tcctgaaatg gtactccaca tcagcattct caagactgga      660

gaagttaggc ctcagacatc ccaagccttc tcctttcatt ggaaacttga catttttccg      720

ccagggtttt tgggaaagcc aaatggagct cagaaagctg tatggacctc tgtgtgggta      780

ctatcttggt cgtcggatgt ttattgttat ttctgagcca gacatgatca agcaggtgtt      840

ggttgagaac ttcagtaact ttaccaacag aatggcgtcg ggtttggagt tcaagtcggt      900

agccgacagc gttctgtttt tacgtgacaa aagatgggaa gaggtcagag gtgccctgat      960

gtctgctttc agtcctgaaa agctgaacga gatggttccc ctcatcagcc aagcctgcga     1020

ccttctcctg gctcatttaa aacgctatgc ggaatctggg gacgcatttg acatccagag     1080

gtgctactgc aattacacca cagatgtggt tgccagcgtc gcctttggca ccccggtgga     1140

ctcctggcag gcccctgagg atccctttgt gaaacactgc aagcgtttct tcgaattctg     1200

catccccaga cctatcctgg ttttactctt atcatttcca tccataatgg tcccactggc     1260

ccggattttg cccaataaga accgagacga actgaatggc ttttttaaca aactcattag     1320

gaatgtgatt gccttgcggg accagcaagc tgccgaagag aggcggagag acttcctcca     1380

aatggtcctg gatgcccgac attctgcaag tcccatgggc gtgcaagact ttgacatcgt     1440

cagagacgtt ttctcctcta ctgggtgcaa gccgaaccct tcccggcaac accagcccag     1500

ccctatggcc aggcctttga ctgtggatga gattgtgggc caggccttca tcttcctcat     1560

cgctggctat gaaatcatca ccaacacact ttcttttgcc acctacctac tggccaccaa     1620

ccctgactgc caagagaagc ttctgagaga ggtagacgtt tttaaggaga aacacatggc     1680

ccctgagttc tgcagcctcg aggaaggcct gccctatctg gacatggtga ttgcagagac     1740

gctgaggatg tacccgccag ctttcagatt cacacgggag gcagctcagg actgcgaggt     1800

gctggggcag cgcatccccg caggcgctgt gctagagatg gccgtgggtg ccctgcacca     1860

tgaccctgag cactggccaa gcccggagac cttcaaccct gaaaggttca cggctgaggc     1920

ccggcagcag caccggccct tcacgtacct gcccttcggg gccggcccac ggagctgcct     1980

cggggtgcgt ctagggctgc ttgaggtcaa gttgacactg ctccacgtgc tgcacaagtt     2040

ccggttccaa gcctgccctg agacccaggt accgctgcag ctagaatcca aatctgccct     2100

aggtccaaaa aatggtgtct atatcaagat cgtatcccgc tgacacagaa ggctgccggg     2160

tggggggagg gcacccccaa attcaaagaa aaccctaagt gtggatgttc agaattttgg     2220

aaaaatgtca ctgaagtgat tgaaagagtg cctggcatgc aaggataaga ggttctttac     2280

ataacatttc ctaaatgctt aataaacgtt tgttgcactt ggttttgaca ttgccaatgg     2340

ggtttgaacc agtgctctct ctaaatgaaa aaaaaaaaaa aaaaa                     2385


<210> 148
<211> 2220
<212> DNA
<213> Homo sapiens

<400> 148
aaggaataaa gttgctgatt cattccttta cactgaaacc ctttgttgtg ccctcctctt       60

ccttcctctt tatagggaga cactctgaga aagagcacat tgtgggggcc cactccatgt      120

gatgtttgct tggttgcctg ttcccttttc tacctgcaga gcacggttcc cataagggcg      180

gcgagatcag cctcctgtct catctggaag accaccactc tggggtctca gaggaatgat      240

ggaagccttg gggtttctaa aattggaagt gaatggcccc atggtgacgg tggccctgtc      300

agtggctctc ttggccctcc tgaaatggta ctccacatca gcattctcaa gactggagaa      360

gttaggcctc agacatccca agccttctcc tttcattgga aacttgacat ttttccgcca      420

gggtttttgg gaaagccaaa tggagctcag aaagctgtat ggacctctgt gtgggtacta      480

tcttggtcgt cggatgttta ttgttatttc tgagccagac atgatcaagc aggtgttggt      540

tgagaacttc agtaacttta ccaacagaat ggcgtcgggt ttggagttca agtcggtagc      600

cgacagcgtt ctgtttttac gtgacaaaag atgggaagag gtcagaggtg ccctgatgtc      660

tgctttcagt cctgaaaagc tgaacgagct tggcctttta atcatgcaag agagaataaa      720

aggtcacatg ggtggccagc aggctccaca aagaattcca cccacccgtt tgtcgaagcc      780

gagtggtatc tatgtgaatc tccattatgc cactctacct ttctgtatgg ttcccctcat      840

cagccaagcc tgcgaccttc tcctggctca tttaaaacgc tatgcggaat ctggggacgc      900

atttgacatc cagaggtgct actgcaatta caccacagat gtggttgcca gcgtcgcctt      960

tggcaccccg gtggactcct ggcaggcccc tgaggatccc tttgtgaaac actgcaagcg     1020

tttcttcgaa ttctgcatcc ccagacctat cctggtttta ctcttatcat ttccatccat     1080

aatggtccca ctggcccgga ttttgcccaa taagaaccga gacgaactga atggcttttt     1140

taacaaactc attaggaatg tgattgcctt gcgggaccag caagctgccg aagagaggcg     1200

gagagacttc ctccaaatgg tcctggatgc ccgacattct gcaagtccca tgggcgtgca     1260

agactttgac atcgtcagag acgttttctc ctctactggg tgcaagccga acccttcccg     1320

gcaacaccag cccagcccta tggccaggcc tttgactgtg gatgagattg tgggccaggc     1380

cttcatcttc ctcatcgctg gctatgaaat catcaccaac acactttctt ttgccaccta     1440

cctactggcc accaaccctg actgccaaga gaagcttctg agagaggtag acgtttttaa     1500

ggagaaacac atggcccctg agttctgcag cctcgaggaa ggcctgccct atctggacat     1560

ggtgattgca gagacgctga ggatgtaccc gccagctttc agattcacac gggaggcagc     1620

tcaggactgc gaggtgctgg ggcagcgcat ccccgcaggc gctgtgctag agatggccgt     1680

gggtgccctg caccatgacc ctgagcactg gccaagcccg gagaccttca accctgaaag     1740

gttcacggct gaggcccggc agcagcaccg gcccttcacg tacctgccct tcggggccgg     1800

cccacggagc tgcctcgggg tgcgtctagg gctgcttgag gtcaagttga cactgctcca     1860

cgtgctgcac aagttccggt tccaagcctg ccctgagacc caggtaccgc tgcagctaga     1920

atccaaatct gccctaggtc caaaaaatgg tgtctatatc aagatcgtat cccgctgaca     1980

cagaaggctg ccgggtgggg ggagggcacc cccaaattca aagaaaaccc taagtgtgga     2040

tgttcagaat tttggaaaaa tgtcactgaa gtgattgaaa gagtgcctgg catgcaagga     2100

taagaggttc tttacataac atttcctaaa tgcttaataa acgtttgttg cacttggttt     2160

tgacattgcc aatggggttt gaaccagtgc tctctctaaa tgaaaaaaaa aaaaaaaaaa     2220


<210> 149
<211> 580
<212> PRT
<213> Homo sapiens

<400> 149
Met Met Glu Ala Leu Gly Phe Leu Lys Leu Glu Val Asn Gly Pro Met 
1               5                   10                  15      


Val Thr Val Ala Leu Ser Val Ala Leu Leu Ala Leu Leu Lys Trp Tyr 
            20                  25                  30          


Ser Thr Ser Ala Phe Ser Arg Leu Glu Lys Leu Gly Leu Arg His Pro 
        35                  40                  45              


Lys Pro Ser Pro Phe Ile Gly Asn Leu Thr Phe Phe Arg Gln Gly Phe 
    50                  55                  60                  


Trp Glu Ser Gln Met Glu Leu Arg Lys Leu Tyr Gly Pro Leu Cys Gly 
65                  70                  75                  80  


Tyr Tyr Leu Gly Arg Arg Met Phe Ile Val Ile Ser Glu Pro Asp Met 
                85                  90                  95      


Ile Lys Gln Val Leu Val Glu Asn Phe Ser Asn Phe Thr Asn Arg Met 
            100                 105                 110         


Ala Ser Gly Leu Glu Phe Lys Ser Val Ala Asp Ser Val Leu Phe Leu 
        115                 120                 125             


Arg Asp Lys Arg Trp Glu Glu Val Arg Gly Ala Leu Met Ser Ala Phe 
    130                 135                 140                 


Ser Pro Glu Lys Leu Asn Glu Leu Gly Leu Leu Ile Met Gln Glu Arg 
145                 150                 155                 160 


Ile Lys Gly His Met Gly Gly Gln Gln Ala Pro Gln Arg Ile Pro Pro 
                165                 170                 175     


Thr Arg Leu Ser Lys Pro Ser Gly Ile Tyr Val Asn Leu His Tyr Ala 
            180                 185                 190         


Thr Leu Pro Phe Cys Met Val Pro Leu Ile Ser Gln Ala Cys Asp Leu 
        195                 200                 205             


Leu Leu Ala His Leu Lys Arg Tyr Ala Glu Ser Gly Asp Ala Phe Asp 
    210                 215                 220                 


Ile Gln Arg Cys Tyr Cys Asn Tyr Thr Thr Asp Val Val Ala Ser Val 
225                 230                 235                 240 


Ala Phe Gly Thr Pro Val Asp Ser Trp Gln Ala Pro Glu Asp Pro Phe 
                245                 250                 255     


Val Lys His Cys Lys Arg Phe Phe Glu Phe Cys Ile Pro Arg Pro Ile 
            260                 265                 270         


Leu Val Leu Leu Leu Ser Phe Pro Ser Ile Met Val Pro Leu Ala Arg 
        275                 280                 285             


Ile Leu Pro Asn Lys Asn Arg Asp Glu Leu Asn Gly Phe Phe Asn Lys 
    290                 295                 300                 


Leu Ile Arg Asn Val Ile Ala Leu Arg Asp Gln Gln Ala Ala Glu Glu 
305                 310                 315                 320 


Arg Arg Arg Asp Phe Leu Gln Met Val Leu Asp Ala Arg His Ser Ala 
                325                 330                 335     


Ser Pro Met Gly Val Gln Asp Phe Asp Ile Val Arg Asp Val Phe Ser 
            340                 345                 350         


Ser Thr Gly Cys Lys Pro Asn Pro Ser Arg Gln His Gln Pro Ser Pro 
        355                 360                 365             


Met Ala Arg Pro Leu Thr Val Asp Glu Ile Val Gly Gln Ala Phe Ile 
    370                 375                 380                 


Phe Leu Ile Ala Gly Tyr Glu Ile Ile Thr Asn Thr Leu Ser Phe Ala 
385                 390                 395                 400 


Thr Tyr Leu Leu Ala Thr Asn Pro Asp Cys Gln Glu Lys Leu Leu Arg 
                405                 410                 415     


Glu Val Asp Val Phe Lys Glu Lys His Met Ala Pro Glu Phe Cys Ser 
            420                 425                 430         


Leu Glu Glu Gly Leu Pro Tyr Leu Asp Met Val Ile Ala Glu Thr Leu 
        435                 440                 445             


Arg Met Tyr Pro Pro Ala Phe Arg Phe Thr Arg Glu Ala Ala Gln Asp 
    450                 455                 460                 


Cys Glu Val Leu Gly Gln Arg Ile Pro Ala Gly Ala Val Leu Glu Met 
465                 470                 475                 480 


Ala Val Gly Ala Leu His His Asp Pro Glu His Trp Pro Ser Pro Glu 
                485                 490                 495     


Thr Phe Asn Pro Glu Arg Phe Thr Ala Glu Ala Arg Gln Gln His Arg 
            500                 505                 510         


Pro Phe Thr Tyr Leu Pro Phe Gly Ala Gly Pro Arg Ser Cys Leu Gly 
        515                 520                 525             


Val Arg Leu Gly Leu Leu Glu Val Lys Leu Thr Leu Leu His Val Leu 
    530                 535                 540                 


His Lys Phe Arg Phe Gln Ala Cys Pro Glu Thr Gln Val Pro Leu Gln 
545                 550                 555                 560 


Leu Glu Ser Lys Ser Ala Leu Gly Pro Lys Asn Gly Val Tyr Ile Lys 
                565                 570                 575     


Ile Val Ser Arg 
            580 


<210> 150
<211> 2132
<212> DNA
<213> Homo sapiens

<400> 150
gagggccggc ctggacccgg cgggcgcacg gctccgagcc cagcgcagcc gagccggtct       60

gcagaggggc ccccagaact ttgtgtgtgt gtgtgcacgc gcgcgcgtgt gtgcccaggt      120

gcgagggttc gcgcgtgtgc tggcggggag ggaaccgacc cgaaagagag ccccacgctg      180

gcaaagtggc tcgcccatct cacagccggt tggcgctcgc ggagctcttt attttccatg      240

tgtgagcctg tgcctgtggt ttatctctgg aggatgtgcc tgagggagga gacatatact      300

gcctggactg cctggctgat gtgagctagt ttgtctggtt gagttggatg tttaaataga      360

aggcagaaca acaacaggta ctccacatca gcattctcaa gactggagaa gttaggcctc      420

agacatccca agccttctcc tttcattgga aacttgacat ttttccgcca gggtttttgg      480

gaaagccaaa tggagctcag aaagctgtat ggacctctgt gtgggtacta tcttggtcgt      540

cggatgttta ttgttatttc tgagccagac atgatcaagc aggtgttggt tgagaacttc      600

agtaacttta ccaacagaat ggcgtcgggt ttggagttca agtcggtagc cgacagcgtt      660

ctgtttttac gtgacaaaag atgggaagag gtcagaggtg ccctgatgtc tgctttcagt      720

cctgaaaagc tgaacgagat ggttcccctc atcagccaag cctgcgacct tctcctggct      780

catttaaaac gctatgcgga atctggggac gcatttgaca tccagaggtg ctactgcaat      840

tacaccacag atgtggttgc cagcgtcgcc tttggcaccc cggtggactc ctggcaggcc      900

cctgaggatc cctttgtgaa acactgcaag cgtttcttcg aattctgcat ccccagacct      960

atcctggttt tactcttatc atttccatcc ataatggtcc cactggcccg gattttgccc     1020

aataagaacc gagacgaact gaatggcttt tttaacaaac tcattaggaa tgtgattgcc     1080

ttgcgggacc agcaagctgc cgaagagagg cggagagact tcctccaaat ggtcctggat     1140

gcccgacatt ctgcaagtcc catgggcgtg caagactttg acatcgtcag agacgttttc     1200

tcctctactg ggtgcaagcc gaacccttcc cggcaacacc agcccagccc tatggccagg     1260

cctttgactg tggatgagat tgtgggccag gccttcatct tcctcatcgc tggctatgaa     1320

atcatcacca acacactttc ttttgccacc tacctactgg ccaccaaccc tgactgccaa     1380

gagaagcttc tgagagaggt agacgttttt aaggagaaac acatggcccc tgagttctgc     1440

agcctcgagg aaggcctgcc ctatctggac atggtgattg cagagacgct gaggatgtac     1500

ccgccagctt tcagattcac acgggaggca gctcaggact gcgaggtgct ggggcagcgc     1560

atccccgcag gcgctgtgct agagatggcc gtgggtgccc tgcaccatga ccctgagcac     1620

tggccaagcc cggagacctt caaccctgaa aggttcacgg ctgaggcccg gcagcagcac     1680

cggcccttca cgtacctgcc cttcggggcc ggcccacgga gctgcctcgg ggtgcgtcta     1740

gggctgcttg aggtcaagtt gacactgctc cacgtgctgc acaagttccg gttccaagcc     1800

tgccctgaga cccaggtacc gctgcagcta gaatccaaat ctgccctagg tccaaaaaat     1860

ggtgtctata tcaagatcgt atcccgctga cacagaaggc tgccgggtgg ggggagggca     1920

cccccaaatt caaagaaaac cctaagtgtg gatgttcaga attttggaaa aatgtcactg     1980

aagtgattga aagagtgcct ggcatgcaag gataagaggt tctttacata acatttccta     2040

aatgcttaat aaacgtttgt tgcacttggt tttgacattg ccaatggggt ttgaaccagt     2100

gctctctcta aatgaaaaaa aaaaaaaaaa aa                                   2132


<210> 151
<211> 466
<212> PRT
<213> Homo sapiens

<400> 151
Met Glu Leu Arg Lys Leu Tyr Gly Pro Leu Cys Gly Tyr Tyr Leu Gly 
1               5                   10                  15      


Arg Arg Met Phe Ile Val Ile Ser Glu Pro Asp Met Ile Lys Gln Val 
            20                  25                  30          


Leu Val Glu Asn Phe Ser Asn Phe Thr Asn Arg Met Ala Ser Gly Leu 
        35                  40                  45              


Glu Phe Lys Ser Val Ala Asp Ser Val Leu Phe Leu Arg Asp Lys Arg 
    50                  55                  60                  


Trp Glu Glu Val Arg Gly Ala Leu Met Ser Ala Phe Ser Pro Glu Lys 
65                  70                  75                  80  


Leu Asn Glu Met Val Pro Leu Ile Ser Gln Ala Cys Asp Leu Leu Leu 
                85                  90                  95      


Ala His Leu Lys Arg Tyr Ala Glu Ser Gly Asp Ala Phe Asp Ile Gln 
            100                 105                 110         


Arg Cys Tyr Cys Asn Tyr Thr Thr Asp Val Val Ala Ser Val Ala Phe 
        115                 120                 125             


Gly Thr Pro Val Asp Ser Trp Gln Ala Pro Glu Asp Pro Phe Val Lys 
    130                 135                 140                 


His Cys Lys Arg Phe Phe Glu Phe Cys Ile Pro Arg Pro Ile Leu Val 
145                 150                 155                 160 


Leu Leu Leu Ser Phe Pro Ser Ile Met Val Pro Leu Ala Arg Ile Leu 
                165                 170                 175     


Pro Asn Lys Asn Arg Asp Glu Leu Asn Gly Phe Phe Asn Lys Leu Ile 
            180                 185                 190         


Arg Asn Val Ile Ala Leu Arg Asp Gln Gln Ala Ala Glu Glu Arg Arg 
        195                 200                 205             


Arg Asp Phe Leu Gln Met Val Leu Asp Ala Arg His Ser Ala Ser Pro 
    210                 215                 220                 


Met Gly Val Gln Asp Phe Asp Ile Val Arg Asp Val Phe Ser Ser Thr 
225                 230                 235                 240 


Gly Cys Lys Pro Asn Pro Ser Arg Gln His Gln Pro Ser Pro Met Ala 
                245                 250                 255     


Arg Pro Leu Thr Val Asp Glu Ile Val Gly Gln Ala Phe Ile Phe Leu 
            260                 265                 270         


Ile Ala Gly Tyr Glu Ile Ile Thr Asn Thr Leu Ser Phe Ala Thr Tyr 
        275                 280                 285             


Leu Leu Ala Thr Asn Pro Asp Cys Gln Glu Lys Leu Leu Arg Glu Val 
    290                 295                 300                 


Asp Val Phe Lys Glu Lys His Met Ala Pro Glu Phe Cys Ser Leu Glu 
305                 310                 315                 320 


Glu Gly Leu Pro Tyr Leu Asp Met Val Ile Ala Glu Thr Leu Arg Met 
                325                 330                 335     


Tyr Pro Pro Ala Phe Arg Phe Thr Arg Glu Ala Ala Gln Asp Cys Glu 
            340                 345                 350         


Val Leu Gly Gln Arg Ile Pro Ala Gly Ala Val Leu Glu Met Ala Val 
        355                 360                 365             


Gly Ala Leu His His Asp Pro Glu His Trp Pro Ser Pro Glu Thr Phe 
    370                 375                 380                 


Asn Pro Glu Arg Phe Thr Ala Glu Ala Arg Gln Gln His Arg Pro Phe 
385                 390                 395                 400 


Thr Tyr Leu Pro Phe Gly Ala Gly Pro Arg Ser Cys Leu Gly Val Arg 
                405                 410                 415     


Leu Gly Leu Leu Glu Val Lys Leu Thr Leu Leu His Val Leu His Lys 
            420                 425                 430         


Phe Arg Phe Gln Ala Cys Pro Glu Thr Gln Val Pro Leu Gln Leu Glu 
        435                 440                 445             


Ser Lys Ser Ala Leu Gly Pro Lys Asn Gly Val Tyr Ile Lys Ile Val 
    450                 455                 460                 


Ser Arg 
465     


<210> 152
<211> 2111
<212> DNA
<213> Homo sapiens

<400> 152
aaggaataaa gttgctgatt cattccttta cactgaaacc ctttgttgtg ccctcctctt       60

ccttcctctt tatagggaga cactctgaga aagagcacat tgtgggggcc cactccatgt      120

gatgtttgct tggttgcctg ttcccttttc tacctgcaga gcacggttcc cataagggcg      180

gcgagatcag cctcctgtct catctggaag accaccactc tggggtctca gaggaatgat      240

ggaagccttg gggtttctaa aattggaagt gaatggcccc atggtgacgg tggccctgtc      300

agtggctctc ttggccctcc tgaaatggta ctccacatca gcattctcaa gactggagaa      360

gttaggcctc agacatccca agccttctcc tttcattgga aacttgacat ttttccgcca      420

gggtttttgg gaaagccaaa tggagctcag aaagctgtat ggacctctgt gtgggtaaga      480

aggaaactca acgtttctat tatgtactat cttggtcgtc ggatgtttat tgttatttct      540

gagccagaca tgatcaagca ggtgttggtt gagaacttca gtaactttac caacagaatg      600

gcgtcgggtt tggagttcaa gtcggtagcc gacagcgttc tgtttttacg tgacaaaaga      660

tgggaagagg tcagaggtgc cctgatgtct gctttcagtc ctgaaaagct gaacgagatg      720

gttcccctca tcagccaagc ctgcgacctt ctcctggctc atttaaaacg ctatgcggaa      780

tctggggacg catttgacat ccagaggtgc tactgcaatt acaccacaga tgtggttgcc      840

agcgtcgcct ttggcacccc ggtggactcc tggcaggccc ctgaggatcc ctttgtgaaa      900

cactgcaagc gtttcttcga attctgcatc cccagaccta tcctggtttt actcttatca      960

tttccatcca taatggtccc actggcccgg attttgccca ataagaaccg agacgaactg     1020

aatggctttt ttaacaaact cattaggaat gtgattgcct tgcgggacca gcaagctgcc     1080

gaagagaggc ggagagactt cctccaaatg gtcctggatg cccgacattc tgcaagtccc     1140

atgggcgtgc aagactttga catcgtcaga gacgttttct cctctactgg gtgcaagccg     1200

aacccttccc ggcaacacca gcccagccct atggccaggc ctttgactgt ggatgagatt     1260

gtgggccagg ccttcatctt cctcatcgct ggctatgaaa tcatcaccaa cacactttct     1320

tttgccacct acctactggc caccaaccct gactgccaag agaagcttct gagagaggta     1380

gacgttttta aggagaaaca catggcccct gagttctgca gcctcgagga aggcctgccc     1440

tatctggaca tggtgattgc agagacgctg aggatgtacc cgccagcttt cagattcaca     1500

cgggaggcag ctcaggactg cgaggtgctg gggcagcgca tccccgcagg cgctgtgcta     1560

gagatggccg tgggtgccct gcaccatgac cctgagcact ggccaagccc ggagaccttc     1620

aaccctgaaa ggttcacggc tgaggcccgg cagcagcacc ggcccttcac gtacctgccc     1680

ttcggggccg gcccacggag ctgcctcggg gtgcgtctag ggctgcttga ggtcaagttg     1740

acactgctcc acgtgctgca caagttccgg ttccaagcct gccctgagac ccaggtaccg     1800

ctgcagctag aatccaaatc tgccctaggt ccaaaaaatg gtgtctatat caagatcgta     1860

tcccgctgac acagaaggct gccgggtggg gggagggcac ccccaaattc aaagaaaacc     1920

ctaagtgtgg atgttcagaa ttttggaaaa atgtcactga agtgattgaa agagtgcctg     1980

gcatgcaagg ataagaggtt ctttacataa catttcctaa atgcttaata aacgtttgtt     2040

gcacttggtt ttgacattgc caatggggtt tgaaccagtg ctctctctaa atgaaaaaaa     2100

aaaaaaaaaa a                                                          2111


<210> 153
<211> 514
<212> PRT
<213> Homo sapiens

<400> 153
Met Val Leu His Ile Ser Ile Leu Lys Thr Gly Glu Val Arg Pro Gln 
1               5                   10                  15      


Thr Ser Gln Ala Phe Ser Phe His Trp Lys Leu Asp Ile Phe Pro Pro 
            20                  25                  30          


Gly Phe Leu Gly Lys Pro Asn Gly Ala Gln Lys Ala Val Trp Thr Ser 
        35                  40                  45              


Val Trp Val Arg Arg Lys Leu Asn Val Ser Ile Met Tyr Tyr Leu Gly 
    50                  55                  60                  


Arg Arg Met Phe Ile Val Ile Ser Glu Pro Asp Met Ile Lys Gln Val 
65                  70                  75                  80  


Leu Val Glu Asn Phe Ser Asn Phe Thr Asn Arg Met Ala Ser Gly Leu 
                85                  90                  95      


Glu Phe Lys Ser Val Ala Asp Ser Val Leu Phe Leu Arg Asp Lys Arg 
            100                 105                 110         


Trp Glu Glu Val Arg Gly Ala Leu Met Ser Ala Phe Ser Pro Glu Lys 
        115                 120                 125             


Leu Asn Glu Met Val Pro Leu Ile Ser Gln Ala Cys Asp Leu Leu Leu 
    130                 135                 140                 


Ala His Leu Lys Arg Tyr Ala Glu Ser Gly Asp Ala Phe Asp Ile Gln 
145                 150                 155                 160 


Arg Cys Tyr Cys Asn Tyr Thr Thr Asp Val Val Ala Ser Val Ala Phe 
                165                 170                 175     


Gly Thr Pro Val Asp Ser Trp Gln Ala Pro Glu Asp Pro Phe Val Lys 
            180                 185                 190         


His Cys Lys Arg Phe Phe Glu Phe Cys Ile Pro Arg Pro Ile Leu Val 
        195                 200                 205             


Leu Leu Leu Ser Phe Pro Ser Ile Met Val Pro Leu Ala Arg Ile Leu 
    210                 215                 220                 


Pro Asn Lys Asn Arg Asp Glu Leu Asn Gly Phe Phe Asn Lys Leu Ile 
225                 230                 235                 240 


Arg Asn Val Ile Ala Leu Arg Asp Gln Gln Ala Ala Glu Glu Arg Arg 
                245                 250                 255     


Arg Asp Phe Leu Gln Met Val Leu Asp Ala Arg His Ser Ala Ser Pro 
            260                 265                 270         


Met Gly Val Gln Asp Phe Asp Ile Val Arg Asp Val Phe Ser Ser Thr 
        275                 280                 285             


Gly Cys Lys Pro Asn Pro Ser Arg Gln His Gln Pro Ser Pro Met Ala 
    290                 295                 300                 


Arg Pro Leu Thr Val Asp Glu Ile Val Gly Gln Ala Phe Ile Phe Leu 
305                 310                 315                 320 


Ile Ala Gly Tyr Glu Ile Ile Thr Asn Thr Leu Ser Phe Ala Thr Tyr 
                325                 330                 335     


Leu Leu Ala Thr Asn Pro Asp Cys Gln Glu Lys Leu Leu Arg Glu Val 
            340                 345                 350         


Asp Val Phe Lys Glu Lys His Met Ala Pro Glu Phe Cys Ser Leu Glu 
        355                 360                 365             


Glu Gly Leu Pro Tyr Leu Asp Met Val Ile Ala Glu Thr Leu Arg Met 
    370                 375                 380                 


Tyr Pro Pro Ala Phe Arg Phe Thr Arg Glu Ala Ala Gln Asp Cys Glu 
385                 390                 395                 400 


Val Leu Gly Gln Arg Ile Pro Ala Gly Ala Val Leu Glu Met Ala Val 
                405                 410                 415     


Gly Ala Leu His His Asp Pro Glu His Trp Pro Ser Pro Glu Thr Phe 
            420                 425                 430         


Asn Pro Glu Arg Phe Thr Ala Glu Ala Arg Gln Gln His Arg Pro Phe 
        435                 440                 445             


Thr Tyr Leu Pro Phe Gly Ala Gly Pro Arg Ser Cys Leu Gly Val Arg 
    450                 455                 460                 


Leu Gly Leu Leu Glu Val Lys Leu Thr Leu Leu His Val Leu His Lys 
465                 470                 475                 480 


Phe Arg Phe Gln Ala Cys Pro Glu Thr Gln Val Pro Leu Gln Leu Glu 
                485                 490                 495     


Ser Lys Ser Ala Leu Gly Pro Lys Asn Gly Val Tyr Ile Lys Ile Val 
            500                 505                 510         


Ser Arg 
        


<210> 154
<211> 1992
<212> DNA
<213> Mus musculus

<400> 154
gcacactcta agaaagagca cttttggggg actcacttga tgggatgttc agctgactac       60

ctacttcttt ctccaccacc tatatacaga tcaggactcc tataagggca ggagagcagc      120

accctctttc ctcctgagga ccacccctcc ggggtctccg aggaaaaatg gaagtgttgg      180

ggcttctcaa gtttgaagtc agtggtacca tagtgactgt gactctgctc gtggctctct      240

tggccctcct gaaatggtac tccatgtcag ctttctcaag actggagaag ttgggcatca      300

ggcaccccaa gccttctcct tttgttggaa acttgatgtt tttccgccag ggtttttggg      360

agagccaatt ggaactccga gagcgatacg ggcctctgtg tgggtactat cttggccgtc      420

ggatgcacgt tgtcatttca gagccagaca tgatcaagca ggtgttggtt gagaacttca      480

gtaacttttc caacagaatg gcctcaggtc tggaacccaa gatggtagca gacagtgtcc      540

tgttgttacg tgacagaaga tgggaggaag tcaggggtgc cctgatgtct tcattcagtc      600

ctgaaaagtt ggatgagatg acacctctca tcagccaagc ctgtgaactt ctcgtggctc      660

acttaaaacg ctatgcagca tccagggacg cattcaacat ccagaggtgt tactgctgtt      720

acaccataga tgtggtggcc agtgtggcct ttggcaccca ggtggactcc cagaattctc      780

cagaagatcc ctttgtgcaa cactgccggc gtgcttccac cttctgtatc cccaggcctc      840

tcctggtatt aatcttatca tttccatcca taatggtccc attggcccgg attctgccca      900

ataagaaccg agatgaactg aatggctttt ttaacacact cattaggaat gtgattgcct      960

tacgggacca gcaagcagca gaagagaggc ggagagactt cctgcagatg gtgctggatg     1020

cccagcactc catgaactct gtgggcgtgg aaggctttga catggtccca gaatccctgt     1080

cctcttctga gtgcacaaag gaaccacccc aaaggtgcca tcctacctcc acatctaagc     1140

ctttcactgt ggatgaaatt gtgggccagg ccttcctctt cctcattgcg ggccatgagg     1200

tcatcacaaa cacgctgtcc ttcatcacat acctgctggc cacccaccct gactgccagg     1260

agaggcttct gaaagaggtg gacctcttca tggggaagca cccagcccct gagtaccaca     1320

gcctgcagga aggtctgccg tatctggaca tggtgatttc agagaccctg aggatgtacc     1380

caccagcttt caggttcaca cgggaggcag cacaggactg tgaggtgctg ggacaacgta     1440

tccctgcagg tacagtgctg gagatagctg tgggtgccct acaccatgac ccagagcact     1500

ggccgaatcc tgagaccttt gaccctgaaa ggttcacagc agaggcccgg cttcagcgga     1560

ggccgttcac atacctgccc tttggagctg gccccaggag ctgcctcgga gtgcggctgg     1620

gcctgctggt ggtcaagctg acaatactcc aggtcctaca caagttccgc tttgaagcca     1680

gccctgagac tcaggttcca cttcagctag aatccaaatc tgccctaggc cccaaaaatg     1740

gagtctacat caagattgtg tcacgctgat atagaaggca cgtgggaaag aggaagcact     1800

ttgtaatggt aacatctgca catcgctgca ggagggcacc cgggattcag atgaaagcct     1860

cgtgtggaga tggagagttt ataggaatat atatcttagg gtgatcaaaa gggcacatgg     1920

catgtgagcc tactttgtca caattcctaa atgtttaata aatgtttacc atgcttcaaa     1980

aaaaaaaaaa aa                                                         1992


<210> 155
<211> 533
<212> PRT
<213> Mus musculus

<400> 155
Met Glu Val Leu Gly Leu Leu Lys Phe Glu Val Ser Gly Thr Ile Val 
1               5                   10                  15      


Thr Val Thr Leu Leu Val Ala Leu Leu Ala Leu Leu Lys Trp Tyr Ser 
            20                  25                  30          


Met Ser Ala Phe Ser Arg Leu Glu Lys Leu Gly Ile Arg His Pro Lys 
        35                  40                  45              


Pro Ser Pro Phe Val Gly Asn Leu Met Phe Phe Arg Gln Gly Phe Trp 
    50                  55                  60                  


Glu Ser Gln Leu Glu Leu Arg Glu Arg Tyr Gly Pro Leu Cys Gly Tyr 
65                  70                  75                  80  


Tyr Leu Gly Arg Arg Met His Val Val Ile Ser Glu Pro Asp Met Ile 
                85                  90                  95      


Lys Gln Val Leu Val Glu Asn Phe Ser Asn Phe Ser Asn Arg Met Ala 
            100                 105                 110         


Ser Gly Leu Glu Pro Lys Met Val Ala Asp Ser Val Leu Leu Leu Arg 
        115                 120                 125             


Asp Arg Arg Trp Glu Glu Val Arg Gly Ala Leu Met Ser Ser Phe Ser 
    130                 135                 140                 


Pro Glu Lys Leu Asp Glu Met Thr Pro Leu Ile Ser Gln Ala Cys Glu 
145                 150                 155                 160 


Leu Leu Val Ala His Leu Lys Arg Tyr Ala Ala Ser Arg Asp Ala Phe 
                165                 170                 175     


Asn Ile Gln Arg Cys Tyr Cys Cys Tyr Thr Ile Asp Val Val Ala Ser 
            180                 185                 190         


Val Ala Phe Gly Thr Gln Val Asp Ser Gln Asn Ser Pro Glu Asp Pro 
        195                 200                 205             


Phe Val Gln His Cys Arg Arg Ala Ser Thr Phe Cys Ile Pro Arg Pro 
    210                 215                 220                 


Leu Leu Val Leu Ile Leu Ser Phe Pro Ser Ile Met Val Pro Leu Ala 
225                 230                 235                 240 


Arg Ile Leu Pro Asn Lys Asn Arg Asp Glu Leu Asn Gly Phe Phe Asn 
                245                 250                 255     


Thr Leu Ile Arg Asn Val Ile Ala Leu Arg Asp Gln Gln Ala Ala Glu 
            260                 265                 270         


Glu Arg Arg Arg Asp Phe Leu Gln Met Val Leu Asp Ala Gln His Ser 
        275                 280                 285             


Met Asn Ser Val Gly Val Glu Gly Phe Asp Met Val Pro Glu Ser Leu 
    290                 295                 300                 


Ser Ser Ser Glu Cys Thr Lys Glu Pro Pro Gln Arg Cys His Pro Thr 
305                 310                 315                 320 


Ser Thr Ser Lys Pro Phe Thr Val Asp Glu Ile Val Gly Gln Ala Phe 
                325                 330                 335     


Leu Phe Leu Ile Ala Gly His Glu Val Ile Thr Asn Thr Leu Ser Phe 
            340                 345                 350         


Ile Thr Tyr Leu Leu Ala Thr His Pro Asp Cys Gln Glu Arg Leu Leu 
        355                 360                 365             


Lys Glu Val Asp Leu Phe Met Gly Lys His Pro Ala Pro Glu Tyr His 
    370                 375                 380                 


Ser Leu Gln Glu Gly Leu Pro Tyr Leu Asp Met Val Ile Ser Glu Thr 
385                 390                 395                 400 


Leu Arg Met Tyr Pro Pro Ala Phe Arg Phe Thr Arg Glu Ala Ala Gln 
                405                 410                 415     


Asp Cys Glu Val Leu Gly Gln Arg Ile Pro Ala Gly Thr Val Leu Glu 
            420                 425                 430         


Ile Ala Val Gly Ala Leu His His Asp Pro Glu His Trp Pro Asn Pro 
        435                 440                 445             


Glu Thr Phe Asp Pro Glu Arg Phe Thr Ala Glu Ala Arg Leu Gln Arg 
    450                 455                 460                 


Arg Pro Phe Thr Tyr Leu Pro Phe Gly Ala Gly Pro Arg Ser Cys Leu 
465                 470                 475                 480 


Gly Val Arg Leu Gly Leu Leu Val Val Lys Leu Thr Ile Leu Gln Val 
                485                 490                 495     


Leu His Lys Phe Arg Phe Glu Ala Ser Pro Glu Thr Gln Val Pro Leu 
            500                 505                 510         


Gln Leu Glu Ser Lys Ser Ala Leu Gly Pro Lys Asn Gly Val Tyr Ile 
        515                 520                 525             


Lys Ile Val Ser Arg 
    530             


<210> 156
<211> 1769
<212> DNA
<213> Homo sapiens

<400> 156
gcagttcctg agagaagaac cctgaggaac agacgttccc tcgcggccct ggcacctcca       60

accccagata tgctgctgct gctgctgctg cccctgctct gggggaggga gagggtggaa      120

ggacagaaga gtaaccggaa ggattactcg ctgacgatgc agagttccgt gaccgtgcaa      180

gagggcatgt gtgtccatgt gcgctgctcc ttctcctacc cagtggacag ccagactgac      240

tctgacccag ttcatggcta ctggttccgg gcagggaatg atataagctg gaaggctcca      300

gtggccacaa acaacccagc ttgggcagtg caggaggaaa ctcgggaccg attccacctc      360

cttggggacc cacagaccaa aaattgcacc ctgagcatca gagatgccag aatgagtgat      420

gcggggagat acttctttcg tatggagaaa ggaaatataa aatggaatta taaatatgac      480

cagctctctg tgaacgtgac agccttgacc cacaggccca acatccttat ccccggtacc      540

ctggagtctg gctgcttcca gaatctgacc tgctctgtgc cctgggcctg tgagcagggg      600

acgcccccta tgatctcctg gatggggacc tctgtgtccc ccctgcaccc ctccaccacc      660

cgctcctcag tgctcaccct catcccacag ccccagcacc acggcaccag cctcacctgt      720

caggtgacct tgcctggggc cggcgtgacc acgaacagga ccatccaact caatgtgtcc      780

taccctcctc agaacttgac tgtgactgtc ttccaaggag aaggcacagc atccacagct      840

ctggggaaca gctcatctct ttcagtccta gagggccagt ctctgcgctt ggtctgtgct      900

gttgacagca atccccctgc caggctgagc tggacctgga ggagtctgac cctgtacccc      960

tcacagccct caaaccctct ggtactggag ctgcaagtgc acctggggga tgaaggggaa     1020

ttcacctgtc gagctcagaa ctctctgggt tcccagcacg tttccctgaa cctctccctg     1080

caacaggagt acacaggcaa aatgaggcct gtatcaggag tgttgctggg ggcggtcggg     1140

ggagctggag ccacagccct ggtcttcctc tccttctgtg tcatcttcat tgtagtgagg     1200

tcctgcagga agaaatcggc aaggccagca gcggacgtgg gagacatagg catgaaggat     1260

gcaaacacca tcaggggctc agcctctcag ggtaacctga ctgagtcctg ggcagatgat     1320

aacccccgac accatggcct ggctgcccac tcctcagggg aggaaagaga gatccagtat     1380

gcacccctca gctttcataa gggggagcct caggacctat caggacaaga agccaccaac     1440

aatgagtact cagagatcaa gatccccaag taagaaaatg cagaggctcg ggcttgtttg     1500

agggttcacg acccctccag caaaggagtc tgaggctgat tccagtagaa ttagcagccc     1560

tcaatgctgt gcaacaagac atcagaactt attcctcttg tctaactgaa aatgcatgcc     1620

tgatgaccaa actctccctt tccccatcca atcggtccac actccccgcc ctggcctctg     1680

gtacccacca ttctcctctg tacttctcta aggatgacta ctttagattc cgaatatagt     1740

gagattgtaa cgtgaaaaaa aaaaaaaaa                                       1769


<210> 157
<211> 467
<212> PRT
<213> Homo sapiens

<400> 157
Met Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Val 
1               5                   10                  15      


Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr 
    50                  55                  60                  


Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr 
65                  70                  75                  80  


Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His 
                85                  90                  95      


Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp 
            100                 105                 110         


Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly 
        115                 120                 125             


Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr 
    130                 135                 140                 


Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser 
145                 150                 155                 160 


Gly Cys Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln 
                165                 170                 175     


Gly Thr Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu 
            180                 185                 190         


His Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro 
        195                 200                 205             


Gln His His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala 
    210                 215                 220                 


Gly Val Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro 
225                 230                 235                 240 


Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr 
                245                 250                 255     


Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu 
            260                 265                 270         


Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp 
        275                 280                 285             


Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu 
    290                 295                 300                 


Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys 
305                 310                 315                 320 


Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser 
                325                 330                 335     


Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu 
            340                 345                 350         


Leu Gly Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser 
        355                 360                 365             


Phe Cys Val Ile Phe Ile Val Val Arg Ser Cys Arg Lys Lys Ser Ala 
    370                 375                 380                 


Arg Pro Ala Ala Asp Val Gly Asp Ile Gly Met Lys Asp Ala Asn Thr 
385                 390                 395                 400 


Ile Arg Gly Ser Ala Ser Gln Gly Asn Leu Thr Glu Ser Trp Ala Asp 
                405                 410                 415     


Asp Asn Pro Arg His His Gly Leu Ala Ala His Ser Ser Gly Glu Glu 
            420                 425                 430         


Arg Glu Ile Gln Tyr Ala Pro Leu Ser Phe His Lys Gly Glu Pro Gln 
        435                 440                 445             


Asp Leu Ser Gly Gln Glu Ala Thr Asn Asn Glu Tyr Ser Glu Ile Lys 
    450                 455                 460                 


Ile Pro Lys 
465         


<210> 158
<211> 1490
<212> DNA
<213> Homo sapiens

<400> 158
gcagttcctg agagaagaac cctgaggaac agacgttccc tcgcggccct ggcacctcca       60

accccagata tgctgctgct gctgctgctg cccctgctct gggggaggga gagggtggaa      120

ggacagaaga gtaaccggaa ggattactcg ctgacgatgc agagttccgt gaccgtgcaa      180

gagggcatgt gtgtccatgt gcgctgctcc ttctcctacc cagtggacag ccagactgac      240

tctgacccag ttcatggcta ctggttccgg gcagggaatg atataagctg gaaggctcca      300

gtggccacaa acaacccagc ttgggcagtg caggaggaaa ctcgggaccg attccacctc      360

cttggggacc cacagaccaa aaattgcacc ctgagcatca gagatgccag aatgagtgat      420

gcggggagat acttctttcg tatggagaaa ggaaatataa aatggaatta taaatatgac      480

cagctctctg tgaacgtgac agaccctcct cagaacttga ctgtgactgt cttccaagga      540

gaaggcacag catccacagc tctggggaac agctcatctc tttcagtcct agagggccag      600

tctctgcgct tggtctgtgc tgttgacagc aatccccctg ccaggctgag ctggacctgg      660

aggagtctga ccctgtaccc ctcacagccc tcaaaccctc tggtactgga gctgcaagtg      720

cacctggggg atgaagggga attcacctgt cgagctcaga actctctggg ttcccagcac      780

gtttccctga acctctccct gcaacaggag tacacaggca aaatgaggcc tgtatcagga      840

gtgttgctgg gggcggtcgg gggagctgga gccacagccc tggtcttcct ctccttctgt      900

gtcatcttca ttgtagtgag gtcctgcagg aagaaatcgg caaggccagc agcggacgtg      960

ggagacatag gcatgaagga tgcaaacacc atcaggggct cagcctctca gggtaacctg     1020

actgagtcct gggcagatga taacccccga caccatggcc tggctgccca ctcctcaggg     1080

gaggaaagag agatccagta tgcacccctc agctttcata agggggagcc tcaggaccta     1140

tcaggacaag aagccaccaa caatgagtac tcagagatca agatccccaa gtaagaaaat     1200

gcagaggctc gggcttgttt gagggttcac gacccctcca gcaaaggagt ctgaggctga     1260

ttccagtaga attagcagcc ctcaatgctg tgcaacaaga catcagaact tattcctctt     1320

gtctaactga aaatgcatgc ctgatgacca aactctccct ttccccatcc aatcggtcca     1380

cactccccgc cctggcctct ggtacccacc attctcctct gtacttctct aaggatgact     1440

actttagatt ccgaatatag tgagattgta acgtgaaaaa aaaaaaaaaa                1490


<210> 159
<211> 374
<212> PRT
<213> Homo sapiens

<400> 159
Met Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Val 
1               5                   10                  15      


Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr 
    50                  55                  60                  


Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr 
65                  70                  75                  80  


Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His 
                85                  90                  95      


Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp 
            100                 105                 110         


Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly 
        115                 120                 125             


Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr 
    130                 135                 140                 


Asp Pro Pro Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr 
145                 150                 155                 160 


Ala Ser Thr Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly 
                165                 170                 175     


Gln Ser Leu Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg 
            180                 185                 190         


Leu Ser Trp Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser 
        195                 200                 205             


Asn Pro Leu Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu 
    210                 215                 220                 


Phe Thr Cys Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu 
225                 230                 235                 240 


Asn Leu Ser Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser 
                245                 250                 255     


Gly Val Leu Leu Gly Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val 
            260                 265                 270         


Phe Leu Ser Phe Cys Val Ile Phe Ile Val Val Arg Ser Cys Arg Lys 
        275                 280                 285             


Lys Ser Ala Arg Pro Ala Ala Asp Val Gly Asp Ile Gly Met Lys Asp 
    290                 295                 300                 


Ala Asn Thr Ile Arg Gly Ser Ala Ser Gln Gly Asn Leu Thr Glu Ser 
305                 310                 315                 320 


Trp Ala Asp Asp Asn Pro Arg His His Gly Leu Ala Ala His Ser Ser 
                325                 330                 335     


Gly Glu Glu Arg Glu Ile Gln Tyr Ala Pro Leu Ser Phe His Lys Gly 
            340                 345                 350         


Glu Pro Gln Asp Leu Ser Gly Gln Glu Ala Thr Asn Asn Glu Tyr Ser 
        355                 360                 365             


Glu Ile Lys Ile Pro Lys 
    370                 


<210> 160
<211> 981
<212> DNA
<213> Homo sapiens

<400> 160
gcagttcctg agagaagaac cctgaggaac agacgttccc tcgcggccct ggcacctcca       60

accccagata tgctgctgct gctgctgctg cccctgctct gggggaggga gagggtggaa      120

ggacagaaga gtaaccggaa ggattactcg ctgacgatgc agagttccgt gaccgtgcaa      180

gagggcatgt gtgtccatgt gcgctgctcc ttctcctacc cagtggacag ccagactgac      240

tctgacccag ttcatggcta ctggttccgg gcagggaatg atataagctg gaaggctcca      300

gtggccacaa acaacccagc ttgggcagtg caggaggaaa ctcgggaccg attccacctc      360

cttggggacc cacagaccaa aaattgcacc ctgagcatca gagatgccag aatgagtgat      420

gcggggagat acttctttcg tatggagaaa ggaaatataa aatggaatta taaatatgac      480

cagctctctg tgaacgtgac agggtaacct gactgagtcc tgggcagatg ataacccccg      540

acaccatggc ctggctgccc actcctcagg ggaggaaaga gagatccagt atgcacccct      600

cagctttcat aagggggagc ctcaggacct atcaggacaa gaagccacca acaatgagta      660

ctcagagatc aagatcccca agtaagaaaa tgcagaggct cgggcttgtt tgagggttca      720

cgacccctcc agcaaaggag tctgaggctg attccagtag aattagcagc cctcaatgct      780

gtgcaacaag acatcagaac ttattcctct tgtctaactg aaaatgcatg cctgatgacc      840

aaactctccc tttccccatc caatcggtcc acactccccg ccctggcctc tggtacccac      900

cattctcctc tgtacttctc taaggatgac tactttagat tccgaatata gtgagattgt      960

aacgtgaaaa aaaaaaaaaa a                                                981


<210> 161
<211> 145
<212> PRT
<213> Homo sapiens

<400> 161
Met Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Val 
1               5                   10                  15      


Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr 
    50                  55                  60                  


Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr 
65                  70                  75                  80  


Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His 
                85                  90                  95      


Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp 
            100                 105                 110         


Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly 
        115                 120                 125             


Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr 
    130                 135                 140                 


Gly 
145 


<210> 162
<211> 1830
<212> PRT
<213> Homo sapiens

<400> 162
Met Ala Pro Trp Arg Lys Ala Asp Lys Glu Arg His Gly Val Ala Ile 
1               5                   10                  15      


Tyr Asn Phe Gln Gly Ser Gly Ala Pro Gln Leu Ser Leu Gln Ile Gly 
            20                  25                  30          


Asp Val Val Arg Ile Gln Glu Thr Cys Gly Asp Trp Tyr Arg Gly Tyr 
        35                  40                  45              


Leu Ile Lys His Lys Met Leu Gln Gly Ile Phe Pro Lys Ser Phe Ile 
    50                  55                  60                  


His Ile Lys Glu Val Thr Val Glu Lys Arg Arg Asn Thr Glu Asn Ile 
65                  70                  75                  80  


Ile Pro Ala Glu Ile Pro Leu Ala Gln Glu Val Thr Thr Thr Leu Trp 
                85                  90                  95      


Glu Trp Gly Ser Ile Trp Lys Gln Leu Tyr Val Ala Ser Lys Lys Glu 
            100                 105                 110         


Arg Phe Leu Gln Val Gln Ser Met Met Tyr Asp Leu Met Glu Trp Arg 
        115                 120                 125             


Ser Gln Leu Leu Ser Gly Thr Leu Pro Lys Asp Glu Leu Lys Glu Leu 
    130                 135                 140                 


Lys Gln Lys Val Thr Ser Lys Ile Asp Tyr Gly Asn Lys Ile Leu Glu 
145                 150                 155                 160 


Leu Asp Leu Ile Val Arg Asp Glu Asp Gly Asn Ile Leu Asp Pro Asp 
                165                 170                 175     


Asn Thr Ser Val Ile Ser Leu Phe His Ala His Glu Glu Ala Thr Asp 
            180                 185                 190         


Lys Ile Thr Glu Arg Ile Lys Glu Glu Met Ser Lys Asp Gln Pro Asp 
        195                 200                 205             


Tyr Ala Met Tyr Ser Arg Ile Ser Ser Ser Pro Thr His Ser Leu Tyr 
    210                 215                 220                 


Val Phe Val Arg Asn Phe Val Cys Arg Ile Gly Glu Asp Ala Glu Leu 
225                 230                 235                 240 


Phe Met Ser Leu Tyr Asp Pro Asn Lys Gln Thr Val Ile Ser Glu Asn 
                245                 250                 255     


Tyr Leu Val Arg Trp Gly Ser Arg Gly Phe Pro Lys Glu Ile Glu Met 
            260                 265                 270         


Leu Asn Asn Leu Lys Val Val Phe Thr Asp Leu Gly Asn Lys Asp Leu 
        275                 280                 285             


Asn Arg Asp Lys Ile Tyr Leu Ile Cys Gln Ile Val Arg Val Gly Lys 
    290                 295                 300                 


Met Asp Leu Lys Asp Thr Gly Ala Lys Lys Cys Thr Gln Gly Leu Arg 
305                 310                 315                 320 


Arg Pro Phe Gly Val Ala Val Met Asp Ile Thr Asp Ile Ile Lys Gly 
                325                 330                 335     


Lys Ala Glu Ser Asp Glu Glu Lys Gln His Phe Ile Pro Phe His Pro 
            340                 345                 350         


Val Thr Ala Glu Asn Asp Phe Leu His Ser Leu Leu Gly Lys Val Ile 
        355                 360                 365             


Ala Ser Lys Gly Asp Ser Gly Gly Gln Gly Leu Trp Val Thr Met Lys 
    370                 375                 380                 


Met Leu Val Gly Asp Ile Ile Gln Ile Arg Lys Asp Tyr Pro His Leu 
385                 390                 395                 400 


Val Asp Arg Thr Thr Val Val Ala Arg Lys Leu Gly Phe Pro Glu Ile 
                405                 410                 415     


Ile Met Pro Gly Asp Val Arg Asn Asp Ile Tyr Ile Thr Leu Leu Gln 
            420                 425                 430         


Gly Asp Phe Asp Lys Tyr Asn Lys Thr Thr Gln Arg Asn Val Glu Val 
        435                 440                 445             


Ile Met Cys Val Cys Ala Glu Asp Gly Lys Thr Leu Pro Asn Ala Ile 
    450                 455                 460                 


Cys Val Gly Ala Gly Asp Lys Pro Met Asn Glu Tyr Arg Ser Val Val 
465                 470                 475                 480 


Tyr Tyr Gln Val Lys Gln Pro Arg Trp Met Glu Thr Val Lys Val Ala 
                485                 490                 495     


Val Pro Ile Glu Asp Met Gln Arg Ile His Leu Arg Phe Met Phe Arg 
            500                 505                 510         


His Arg Ser Ser Leu Glu Ser Lys Asp Lys Gly Glu Lys Asn Phe Ala 
        515                 520                 525             


Met Ser Tyr Val Lys Leu Met Lys Glu Asp Gly Thr Thr Leu His Asp 
    530                 535                 540                 


Gly Phe His Asp Leu Val Val Leu Lys Gly Asp Ser Lys Lys Met Glu 
545                 550                 555                 560 


Asp Ala Ser Ala Tyr Leu Thr Leu Pro Ser Tyr Arg His His Val Glu 
                565                 570                 575     


Asn Lys Gly Ala Thr Leu Ser Arg Ser Ser Ser Ser Val Gly Gly Leu 
            580                 585                 590         


Ser Val Ser Ser Arg Asp Val Phe Ser Ile Ser Thr Leu Val Cys Ser 
        595                 600                 605             


Thr Lys Leu Thr Gln Asn Val Gly Leu Leu Gly Leu Leu Lys Trp Arg 
    610                 615                 620                 


Met Lys Pro Gln Leu Leu Gln Glu Asn Leu Glu Lys Leu Lys Ile Val 
625                 630                 635                 640 


Asp Gly Glu Glu Val Val Lys Phe Leu Gln Asp Thr Leu Asp Ala Leu 
                645                 650                 655     


Phe Asn Ile Met Met Glu His Ser Gln Ser Asp Glu Tyr Asp Ile Leu 
            660                 665                 670         


Val Phe Asp Ala Leu Ile Tyr Ile Ile Gly Leu Ile Ala Asp Arg Lys 
        675                 680                 685             


Phe Gln His Phe Asn Thr Val Leu Glu Ala Tyr Ile Gln Gln His Phe 
    690                 695                 700                 


Ser Ala Thr Leu Ala Tyr Lys Lys Leu Met Thr Val Leu Lys Thr Tyr 
705                 710                 715                 720 


Leu Asp Thr Ser Ser Arg Gly Glu Gln Cys Glu Pro Ile Leu Arg Thr 
                725                 730                 735     


Leu Lys Ala Leu Glu Tyr Val Phe Lys Phe Ile Val Arg Ser Arg Thr 
            740                 745                 750         


Leu Phe Ser Gln Leu Tyr Glu Gly Lys Glu Gln Met Glu Phe Glu Glu 
        755                 760                 765             


Ser Met Arg Arg Leu Phe Glu Ser Ile Asn Asn Leu Met Lys Ser Gln 
    770                 775                 780                 


Tyr Lys Thr Thr Ile Leu Leu Gln Val Ala Ala Leu Lys Tyr Ile Pro 
785                 790                 795                 800 


Ser Val Leu His Asp Val Glu Met Val Phe Asp Ala Lys Leu Leu Ser 
                805                 810                 815     


Gln Leu Leu Tyr Glu Phe Tyr Thr Cys Ile Pro Pro Val Lys Leu Gln 
            820                 825                 830         


Lys Gln Lys Val Gln Ser Met Asn Glu Ile Val Gln Ser Asn Leu Phe 
        835                 840                 845             


Lys Lys Gln Glu Cys Arg Asp Ile Leu Leu Pro Val Ile Thr Lys Glu 
    850                 855                 860                 


Leu Lys Glu Leu Leu Glu Gln Lys Asp Asp Met Gln His Gln Val Leu 
865                 870                 875                 880 


Glu Arg Lys Tyr Cys Val Glu Leu Leu Asn Ser Ile Leu Glu Val Leu 
                885                 890                 895     


Ser Tyr Gln Asp Ala Ala Phe Thr Tyr His His Ile Gln Glu Ile Met 
            900                 905                 910         


Val Gln Leu Leu Arg Thr Val Asn Arg Thr Val Ile Thr Met Gly Arg 
        915                 920                 925             


Asp His Ile Leu Ile Ser His Phe Val Ala Cys Met Thr Ala Ile Leu 
    930                 935                 940                 


Asn Gln Met Gly Asp Gln His Tyr Ser Phe Tyr Ile Glu Thr Phe Gln 
945                 950                 955                 960 


Thr Ser Ser Glu Leu Val Asp Phe Leu Met Glu Thr Phe Ile Met Phe 
                965                 970                 975     


Lys Asp Leu Ile Gly Lys Asn Val Tyr Pro Gly Asp Trp Met Ala Met 
            980                 985                 990         


Ser Met Val Gln Asn Arg Val Phe  Leu Arg Ala Ile Asn  Lys Phe Ala 
        995                 1000                 1005             


Glu Thr  Met Asn Gln Lys Phe  Leu Glu His Thr Asn  Phe Glu Phe 
    1010                 1015                 1020             


Gln Leu  Trp Asn Asn Tyr Phe  His Leu Ala Val Ala  Phe Ile Thr 
    1025                 1030                 1035             


Gln Asp  Ser Leu Gln Leu Glu  Gln Phe Ser His Ala  Lys Tyr Asn 
    1040                 1045                 1050             


Lys Ile  Leu Asn Lys Tyr Gly  Asp Met Arg Arg Leu  Ile Gly Phe 
    1055                 1060                 1065             


Ser Ile  Arg Asp Met Trp Tyr  Lys Leu Gly Gln Asn  Lys Ile Cys 
    1070                 1075                 1080             


Phe Ile  Pro Gly Met Val Gly  Pro Ile Leu Glu Met  Thr Leu Ile 
    1085                 1090                 1095             


Pro Glu  Ala Glu Leu Arg Lys  Ala Thr Ile Pro Ile  Phe Phe Asp 
    1100                 1105                 1110             


Met Met  Leu Cys Glu Tyr Gln  Arg Ser Gly Asp Phe  Lys Lys Phe 
    1115                 1120                 1125             


Glu Asn  Glu Ile Ile Leu Lys  Leu Asp His Glu Val  Glu Gly Gly 
    1130                 1135                 1140             


Arg Gly  Asp Glu Gln Tyr Met  Gln Leu Leu Glu Ser  Ile Leu Met 
    1145                 1150                 1155             


Glu Cys  Ala Ala Glu His Pro  Thr Ile Ala Lys Ser  Val Glu Asn 
    1160                 1165                 1170             


Phe Val  Asn Leu Val Lys Gly  Leu Leu Glu Lys Leu  Leu Asp Tyr 
    1175                 1180                 1185             


Arg Gly  Val Met Thr Asp Glu  Ser Lys Asp Asn Arg  Met Ser Cys 
    1190                 1195                 1200             


Thr Val  Asn Leu Leu Asn Phe  Tyr Lys Asp Asn Asn  Arg Glu Glu 
    1205                 1210                 1215             


Met Tyr  Ile Arg Tyr Leu Tyr  Lys Leu Arg Asp Leu  His Leu Asp 
    1220                 1225                 1230             


Cys Asp  Asn Tyr Thr Glu Ala  Ala Tyr Thr Leu Leu  Leu His Thr 
    1235                 1240                 1245             


Trp Leu  Leu Lys Trp Ser Asp  Glu Gln Cys Ala Ser  Gln Val Met 
    1250                 1255                 1260             


Gln Thr  Gly Gln Gln His Pro  Gln Thr His Arg Gln  Leu Lys Glu 
    1265                 1270                 1275             


Thr Leu  Tyr Glu Thr Ile Ile  Gly Tyr Phe Asp Lys  Gly Lys Met 
    1280                 1285                 1290             


Trp Glu  Glu Ala Ile Ser Leu  Cys Lys Glu Leu Ala  Glu Gln Tyr 
    1295                 1300                 1305             


Glu Met  Glu Ile Phe Asp Tyr  Glu Leu Leu Ser Gln  Asn Leu Ile 
    1310                 1315                 1320             


Gln Gln  Ala Lys Phe Tyr Glu  Ser Ile Met Lys Ile  Leu Arg Pro 
    1325                 1330                 1335             


Lys Pro  Asp Tyr Phe Ala Val  Gly Tyr Tyr Gly Gln  Gly Phe Pro 
    1340                 1345                 1350             


Ser Phe  Leu Arg Asn Lys Val  Phe Ile Tyr Arg Gly  Lys Glu Tyr 
    1355                 1360                 1365             


Glu Arg  Arg Glu Asp Phe Gln  Met Gln Leu Met Thr  Gln Phe Pro 
    1370                 1375                 1380             


Asn Ala  Glu Lys Met Asn Thr  Thr Ser Ala Pro Gly  Asp Asp Val 
    1385                 1390                 1395             


Lys Asn  Ala Pro Gly Gln Tyr  Ile Gln Cys Phe Thr  Val Gln Pro 
    1400                 1405                 1410             


Val Leu  Asp Glu His Pro Arg  Phe Lys Asn Lys Pro  Val Pro Asp 
    1415                 1420                 1425             


Gln Ile  Ile Asn Phe Tyr Lys  Ser Asn Tyr Val Gln  Arg Phe His 
    1430                 1435                 1440             


Tyr Ser  Arg Pro Val Arg Arg  Gly Thr Val Asp Pro  Glu Asn Glu 
    1445                 1450                 1455             


Phe Ala  Ser Met Trp Ile Glu  Arg Thr Ser Phe Val  Thr Ala Tyr 
    1460                 1465                 1470             


Lys Leu  Pro Gly Ile Leu Arg  Trp Phe Glu Val Val  His Met Ser 
    1475                 1480                 1485             


Gln Thr  Thr Ile Ser Pro Leu  Glu Asn Ala Ile Glu  Thr Met Ser 
    1490                 1495                 1500             


Thr Ala  Asn Glu Lys Ile Leu  Met Met Ile Asn Gln  Tyr Gln Ser 
    1505                 1510                 1515             


Asp Glu  Thr Leu Pro Ile Asn  Pro Leu Ser Met Leu  Leu Asn Gly 
    1520                 1525                 1530             


Ile Val  Asp Pro Ala Val Met  Gly Gly Phe Ala Lys  Tyr Glu Lys 
    1535                 1540                 1545             


Ala Phe  Phe Thr Glu Glu Tyr  Val Arg Asp His Pro  Glu Asp Gln 
    1550                 1555                 1560             


Asp Lys  Leu Thr His Leu Lys  Asp Leu Ile Ala Trp  Gln Ile Pro 
    1565                 1570                 1575             


Phe Leu  Gly Ala Gly Ile Lys  Ile His Glu Lys Arg  Val Ser Asp 
    1580                 1585                 1590             


Asn Leu  Arg Pro Phe His Asp  Arg Met Glu Glu Cys  Phe Lys Asn 
    1595                 1600                 1605             


Leu Lys  Met Lys Val Glu Lys  Glu Tyr Gly Val Arg  Glu Met Pro 
    1610                 1615                 1620             


Asp Phe  Asp Asp Arg Arg Val  Gly Arg Pro Arg Ser  Met Leu Arg 
    1625                 1630                 1635             


Ser Tyr  Arg Gln Met Ser Ile  Ile Ser Leu Ala Ser  Met Asn Ser 
    1640                 1645                 1650             


Asp Cys  Ser Thr Pro Ser Lys  Pro Thr Ser Glu Ser  Phe Asp Leu 
    1655                 1660                 1665             


Glu Leu  Ala Ser Pro Lys Thr  Pro Arg Val Glu Gln  Glu Glu Pro 
    1670                 1675                 1680             


Ile Ser  Pro Gly Ser Thr Leu  Pro Glu Val Lys Leu  Arg Arg Ser 
    1685                 1690                 1695             


Lys Lys  Arg Thr Lys Arg Ser  Ser Val Val Phe Ala  Asp Glu Lys 
    1700                 1705                 1710             


Ala Ala  Ala Glu Ser Asp Leu  Lys Arg Leu Ser Arg  Lys His Glu 
    1715                 1720                 1725             


Phe Met  Ser Asp Thr Asn Leu  Ser Glu His Ala Ala  Ile Pro Leu 
    1730                 1735                 1740             


Lys Ala  Ser Val Leu Ser Gln  Met Ser Phe Ala Ser  Gln Ser Met 
    1745                 1750                 1755             


Pro Thr  Ile Pro Ala Leu Ala  Leu Ser Val Ala Gly  Ile Pro Gly 
    1760                 1765                 1770             


Leu Asp  Glu Ala Asn Thr Ser  Pro Arg Leu Ser Gln  Thr Phe Leu 
    1775                 1780                 1785             


Gln Leu  Ser Asp Gly Asp Lys  Lys Thr Leu Thr Arg  Lys Lys Val 
    1790                 1795                 1800             


Asn Gln  Phe Phe Lys Thr Met  Leu Ala Ser Lys Ser  Ala Glu Glu 
    1805                 1810                 1815             


Gly Lys  Gln Ile Pro Asp Ser  Leu Ser Thr Asp Leu  
    1820                 1825                 1830 


<210> 163
<211> 6069
<212> DNA
<213> Homo sapiens

<400> 163
agccaccccc tgacggcttc cccacgggag gacgcgaggc cccggcccag ccatggcccc       60

ctggcgcaaa gctgacaagg agcggcacgg cgtggccata tacaacttcc aaggcagcgg      120

agccccccag ctctccctgc agatcggcga tgtggtgcga atacaggaga cgtgtggaga      180

ctggtatagg ggatacctca taaagcacaa aatgttacag ggcatttttc ctaagtcatt      240

tatccacatc aaggaagtga cagttgagaa aagaagaaat actgagaaca tcattcctgc      300

agaaattcct ctggcacaag aagtgacaac gacactttgg gaatggggaa gcatctggaa      360

acaactctat gtggccagca aaaaggagcg ttttctccag gtgcagtcca tgatgtacga      420

tctgatggag tggaggtccc agcttctctc aggaacctta cccaaggatg agctgaagga      480

actgaagcag aaagtcacgt ccaaaattga ctatggcaac aaaatccttg agcttgattt      540

gattgtcaga gatgaagacg gaaatatctt ggaccctgat aataccagtg tcatcagctt      600

gttccatgca catgaggaag caactgataa aatcacagag cgtatcaaag aagaaatgtc      660

aaaagaccag ccagattatg caatgtattc ccggatctcc tcatccccca cccatagcct      720

ctatgtgttt gtgagaaact ttgtgtgcag aattggggaa gatgctgagc tcttcatgtc      780

tctctacgac cccaacaagc aaacggtcat aagtgagaac tacctagtgc gatggggcag      840

ccggggcttc cctaaggaga ttgagatgct caacaatctg aaggtggtct tcacggatct      900

tggaaacaaa gacctcaaca gggataaaat ttacttgatt tgtcaaatag tccgggtcgg      960

caagatggat cttaaggata ctggtgcaaa gaagtgcacg cagggactga ggaggccctt     1020

tggggtggca gttatggata taacagacat catcaagggg aaagcagaga gtgatgaaga     1080

aaagcagcac ttcattcctt ttcacccggt tacagctgag aatgacttcc tacacagcct     1140

gctgggcaaa gtcatagcct ccaaggggga cagtggaggg caaggcctct gggtgaccat     1200

gaagatgctg gtgggtgaca tcattcagat tcgcaaggac tatccacacc tggtggacag     1260

gaccaccgtg gtggccagga agctgggatt cccagagatc atcatgccag gggatgtcag     1320

gaacgacatc tacattactc tcttacaagg tgactttgac aagtacaaca agaccacaca     1380

gaggaatgtg gaagtcatca tgtgtgtgtg cgcggaggat ggcaaaacgc tgcctaatgc     1440

aatttgcgtg ggagcagggg acaagcccat gaatgagtat cgctccgttg tgtactatca     1500

agtcaaacag ccacgctgga tggaaacagt caaggtggct gtccctattg aagacatgca     1560

gaggatccat ctgcgattca tgtttcgaca tcggtcatct ctggaatcta aagataaagg     1620

agaaaagaac tttgccatgt cctatgtgaa gctgatgaaa gaagatggga ctactctaca     1680

cgatggattc catgacttag ttgtcctcaa gggggacagc aagaagatgg aggatgccag     1740

cgcatacctg acccttcctt cttatcgaca ccatgtggaa aacaaggggg ccacgctgag     1800

caggagctcc agcagtgttg gggggctttc tgtcagctcc cgggatgtgt tctccatttc     1860

caccctggtg tgctccacaa agctcactca gaatgtgggc ttgctgggtt tgctgaagtg     1920

gcgtatgaag cctcaactgc tacaggagaa tttagaaaag ttgaagattg tggatggaga     1980

ggaagtggtg aagtttctcc aggatactct ggatgccctc ttcaacatca tgatggagca     2040

ttctcaaagt gatgaatatg acatcctcgt ctttgatgcc ttgatttaca taataggact     2100

cattgcagac cggaaatttc agcatttcaa caccgttctg gaggcttaca tccaacagca     2160

tttcagtgcg accttggctt acaagaaatt gatgacagtg ctgaagactt acttggatac     2220

ctccagcaga ggggagcaat gtgagccaat cctaagaacg ctgaaggctt tggaatatgt     2280

gttcaagttc attgttcggt cgaggacatt attttcacag ctttatgaag gcaaagaaca     2340

gatggagttt gaagaatcca tgagacggct ctttgaatcc atcaacaatc tgatgaaaag     2400

tcaatacaaa actaccatcc ttttgcaggt ggcggctttg aaatacatcc catctgtcct     2460

gcatgatgta gaaatggtct ttgatgcgaa gttactcagc caactcctgt atgagttcta     2520

cacctgcatc cctcctgtga aactccagaa gcagaaagta cagtctatga atgagatagt     2580

ccagagcaac ctctttaaaa agcaagaatg ccgggacatt ctgcttcctg tcatcaccaa     2640

agagctgaag gagctgctgg agcagaagga tgacatgcaa caccaggtcc tggagaggaa     2700

gtactgcgtt gaattgctca acagcatctt ggaagtcctt agctaccagg atgcggcctt     2760

cacctaccac catatccagg agatcatggt ccagctgctg cggacagtga accggacagt     2820

catcaccatg ggccgggatc acattctgat tagtcacttt gtggcatgta tgacagccat     2880

cttaaaccag atgggtgacc agcactactc cttctacatt gagaccttcc agaccagctc     2940

tgaacttgtg gacttcttga tggagacctt catcatgttc aaggacctca ttggaaagaa     3000

cgtgtaccct ggagactgga tggccatgag catggttcaa aacagggtct tcctgagagc     3060

tatcaacaag tttgcagaaa ccatgaacca gaagttccta gaacacacga actttgagtt     3120

ccagctgtgg aacaactatt ttcatctggc agtggctttt atcacccagg attctctgca     3180

gctggagcag ttctcacacg ccaaatacaa caaaatcctg aataagtatg gggacatgag     3240

acggctaatt ggcttctcca tccgtgatat gtggtacaag cttggtcaga acaaaatctg     3300

cttcatccca ggcatggtag gacctatatt agagatgaca cttatccctg aggctgagct     3360

ccggaaagcc accataccaa tcttcttcga catgatgctg tgtgaatatc aaagaagtgg     3420

ggatttcaaa aagtttgaaa acgaaatcat cctgaagctg gaccacgagg tagaaggggg     3480

ccgaggcgac gagcagtaca tgcagctcct ggagtcaatc ctgatggaat gtgctgcaga     3540

gcacccaacc attgccaagt cggtggagaa cttcgtgaac ctggtcaaag gcctcctgga     3600

gaagctgctg gattaccggg gtgtgatgac agatgagagc aaagacaacc gcatgagctg     3660

caccgtgaac ctgctgaatt tctacaaaga taacaacagg gaggagatgt acataaggta     3720

cctgtacaaa ctccgcgatc ttcacctgga ctgtgacaat tacacagagg ctgcctacac     3780

gctccttctc cacacctggc ttctcaagtg gtcggatgag cagtgtgcat cacaggtcat     3840

gcagacaggc cagcagcacc cccagacaca ccggcagctg aaggagacgc tctacgagac     3900

catcataggc tactttgaca aaggaaagat gtgggaagag gccataagtc tgtgcaagga     3960

gctggcggaa cagtacgaga tggagatctt tgactatgag ctgctcagcc agaacctgat     4020

ccagcaggca aaattctatg aaagcatcat gaaaatcctc aggcccaaac cagactactt     4080

tgctgttgga tactacggcc agggattccc ctccttcctg cggaacaaag tgttcatcta     4140

ccgcgggaag gaatatgagc gaagagaaga tttccagatg cagctgatga cccagttccc     4200

caatgcagag aagatgaaca ccacctctgc cccgggagat gatgtgaaga atgccccagg     4260

ccagtatatc cagtgcttca ctgtccagcc tgtcttggat gaacatccca ggttcaagaa     4320

taagccagtg cctgaccaga ttataaactt ctacaaatcc aactacgtgc aaaggttcca     4380

ctactcccgg cccgtgcgca gggggaccgt agacccagag aatgagtttg cttccatgtg     4440

gattgagaga acctccttcg tgactgcata caagctgccg gggatcctgc gctggtttga     4500

ggtggtgcac atgtcgcaga ccacaattag tcctctggag aatgccatag aaaccatgtc     4560

cacggccaat gagaagatcc tgatgatgat aaaccagtac cagagtgatg agaccctccc     4620

catcaaccca ctctccatgc tcctgaacgg gattgtggac cctgctgtca tgggaggctt     4680

cgccaagtat gagaaggcct tcttcactga agagtatgtc agggaccacc ctgaggacca     4740

ggacaagctg acccacctca aggacctgat tgcatggcag atccccttct tgggagctgg     4800

gattaagatc catgagaaaa gggtgtcaga taacttgcga cccttccatg accggatgga     4860

ggaatgtttc aagaacctga aaatgaaggt ggagaaggag tacggtgtcc gagagatgcc     4920

tgactttgac gacaggagag tgggccgtcc caggtctatg ctgcgctcat acagacagat     4980

gtccatcatc tctctggctt ccatgaattc tgactgcagc acccccagca agcctacctc     5040

agagagcttt gacctggaat tagcatcacc caagacgccg agagtggagc aggaggaacc     5100

gatctccccg gggagcaccc tgcctgaggt caagctgcgg aggtccaaga agaggacaaa     5160

gagaagcagc gtagtttttg cggatgagaa agcagctgca gagtcggacc tgaagcggct     5220

ttccaggaag catgagttca tgagtgacac caacctctcg gagcatgcgg ccatccccct     5280

caaggcgtct gtcctctctc aaatgagctt tgccagccag tccatgccta ccatcccagc     5340

cctggcgctc tcagtggcag gcatccctgg gttggatgag gccaacacat ctccccgcct     5400

cagccagacc ttcctccaac tctcagatgg tgacaagaag acactcacac ggaagaaggt     5460

caatcagttc ttcaagacaa tgctggccag caaatcggct gaagaaggca aacagatccc     5520

agactcgctg tccacggacc tgtgagctgc tgctgactag ggctgcatgg gagagccagg     5580

gaggggagtt tctggaagag gaaagccatg cgtggaacat cgaagcctca gagagtggga     5640

gactgtcccc atcagttgtc cttacttaga ggagacagag aggccaatca ggtcccagag     5700

cttgaatgct aacaagccca gcatcccctg gggctgtgat catggtggat gaggaagcct     5760

caacgtagat tcctgaactc aaggtaccag caagaatgcc ttctcccagt gtgctctccc     5820

caacatccta ggcacagctt tcataaccca gtttcttagg tgtaagaaac tgtttttatc     5880

tcatttatta agtctcagaa cttaacagaa aaggaagcct tttaaatatt ctttttaatt     5940

ttattttaga ttaacagttt tgtactttac atttttttat acaaccaacc agtttctttt     6000

ctagccaatc atctctgaag agttgctgtt tcttactgac aataaaaaat gttctcttgg     6060

ttcgaataa                                                             6069


<210> 164
<211> 1828
<212> PRT
<213> Mus musculus

<400> 164
Met Ala Pro Trp Arg Lys Thr Asp Lys Glu Arg His Gly Val Ala Ile 
1               5                   10                  15      


Tyr Asn Phe Gln Gly Ser Glu Ala Gln His Leu Thr Leu Gln Ile Gly 
            20                  25                  30          


Asp Val Val Arg Ile Gln Glu Thr Cys Gly Asp Trp Tyr Arg Gly Tyr 
        35                  40                  45              


Leu Ile Lys His Lys Leu Ser Gln Gly Ile Phe Pro Thr Ser Phe Ile 
    50                  55                  60                  


His Leu Lys Glu Val Thr Val Glu Lys Arg Arg Asn Ile Glu Asn Ile 
65                  70                  75                  80  


Ile Pro Ala Glu Ile Pro Leu Ala Gln Glu Val Thr Thr Thr Leu Trp 
                85                  90                  95      


Glu Trp Gly Ser Ile Trp Lys Gln Leu Tyr Val Ala Ser Lys Lys Glu 
            100                 105                 110         


Arg Phe Leu Gln Val Gln Ser Met Met Tyr Asp Leu Met Glu Trp Arg 
        115                 120                 125             


Ser Gln Leu Leu Ser Gly Thr Leu Pro Lys Asp Glu Leu Lys Glu Leu 
    130                 135                 140                 


Lys Gln Lys Val Thr Ser Lys Ile Asp Tyr Gly Asn Lys Ile Leu Glu 
145                 150                 155                 160 


Leu Asp Leu Ile Val Arg Asp Glu Asp Gly Asn Ile Leu Asp Pro Asp 
                165                 170                 175     


Lys Thr Ser Val Ile Ser Leu Phe His Ala His Glu Glu Ala Thr Tyr 
            180                 185                 190         


Lys Ile Thr Glu Arg Ile Lys Glu Glu Met Ser Lys Asp Gln Pro Asp 
        195                 200                 205             


Tyr Gly Val Tyr Ser Arg Ile Ser Ser Ser Pro Thr His Ser Leu Tyr 
    210                 215                 220                 


Val Phe Val Arg Asn Phe Val Cys Arg Ile Gly Glu Asp Ala Glu Leu 
225                 230                 235                 240 


Phe Met Ser Leu Tyr Asp Pro His Lys Gln Thr Val Ile Ser Glu Asn 
                245                 250                 255     


Tyr Leu Val Arg Trp Gly Ser Lys Gly Phe Pro Lys Glu Ile Glu Met 
            260                 265                 270         


Leu Asn Asn Leu Lys Val Val Phe Thr Asp Leu Gly Asn Lys Asp Leu 
        275                 280                 285             


Asn Arg Asp Lys Ile Phe Leu Ile Cys Gln Ile Val Arg Ile Gly Lys 
    290                 295                 300                 


Met Asp Leu Lys Asp Ile Asn Ala Lys Lys Cys Thr Gln Gly Leu Arg 
305                 310                 315                 320 


Arg Pro Phe Gly Val Ala Val Met Asp Ile Thr Asp Ile Ile Lys Gly 
                325                 330                 335     


Lys Ala Glu Ser Asp Glu Glu Lys Gln His Phe Ile Pro Phe His Pro 
            340                 345                 350         


Val Ser Ala Glu Asn Asp Phe Leu His Ser Leu Leu Gly Lys Val Ile 
        355                 360                 365             


Ala Ser Lys Gly Asp Ser Gly Gly Gln Gly Leu Trp Val Thr Met Lys 
    370                 375                 380                 


Met Leu Val Gly Asp Ile Ile Gln Ile Arg Lys Asp Tyr Pro His Leu 
385                 390                 395                 400 


Val Asp Arg Thr Thr Val Val Ala Arg Lys Leu Gly Phe Pro Glu Ile 
                405                 410                 415     


Ile Met Pro Gly Asp Val Arg Asn Asp Ile Tyr Ile Thr Leu Leu Gln 
            420                 425                 430         


Gly Asp Phe Asp Lys Tyr Thr Lys Thr Thr Gln Arg Asn Val Glu Val 
        435                 440                 445             


Ile Met Cys Val Cys Thr Glu Asp Gly Lys Val Leu Pro Asn Ala Ile 
    450                 455                 460                 


Cys Val Gly Ala Gly Asp Lys Ala Met Asn Glu Tyr His Ser Val Val 
465                 470                 475                 480 


Tyr Tyr Gln Val Lys Gln Pro Arg Trp Met Glu Thr Val Lys Val Ala 
                485                 490                 495     


Val Pro Ile Glu Asp Met Gln Arg Ile His Leu Arg Phe Met Phe Arg 
            500                 505                 510         


His Arg Ser Ser Leu Glu Ser Lys Asp Lys Gly Glu Lys Asn Phe Ala 
        515                 520                 525             


Met Ser Tyr Val Lys Leu Met Lys Glu Asp Gly Thr Thr Leu His Asp 
    530                 535                 540                 


Gly Tyr His Glu Leu Val Val Leu Lys Gly Asp Ser Lys Lys Met Glu 
545                 550                 555                 560 


Asp Ala Ser Ala Tyr Leu Thr Leu Pro Ser Tyr Arg His Pro Val Glu 
                565                 570                 575     


Asn Lys Gly Ala Thr Leu Ser Arg Ser Ser Ser Ser Val Gly Gly Leu 
            580                 585                 590         


Ser Val Ser Ser Arg Asp Val Phe Ser Ile Ser Thr Leu Val Cys Ser 
        595                 600                 605             


Thr Lys Leu Thr Gln Asn Val Gly Leu Leu Gly Leu Leu Lys Trp Arg 
    610                 615                 620                 


Met Lys Pro Gln Leu Leu Gln Glu Asn Leu Glu Lys Leu Lys Ile Val 
625                 630                 635                 640 


Asp Gly Glu Glu Val Val Lys Phe Leu Gln Asp Thr Leu Asp Ala Leu 
                645                 650                 655     


Phe Asn Ile Met Met Glu His Ser Gln Ser Asn Glu Tyr Asp Ile Leu 
            660                 665                 670         


Val Phe Asp Ala Leu Ile Tyr Ile Ile Gly Leu Ile Ala Asp Arg Lys 
        675                 680                 685             


Phe Gln His Phe Asn Thr Val Leu Glu Ala Tyr Ile Gln Gln His Phe 
    690                 695                 700                 


Ser Ala Thr Leu Ala Tyr Lys Lys Leu Met Thr Val Leu Lys Thr Tyr 
705                 710                 715                 720 


Leu Asp Thr Ser Ser Arg Gly Glu Gln Cys Glu Pro Ile Leu Arg Thr 
                725                 730                 735     


Leu Lys Ala Leu Glu Tyr Val Phe Lys Phe Ile Val Arg Ser Arg Thr 
            740                 745                 750         


Leu Phe Ser Gln Leu Tyr Glu Gly Lys Glu Gln Met Glu Phe Glu Glu 
        755                 760                 765             


Ser Met Arg Arg Leu Phe Glu Ser Ile Asn Asn Leu Met Lys Ser Gln 
    770                 775                 780                 


Tyr Lys Thr Thr Ile Leu Leu Gln Val Ala Ala Leu Lys Tyr Ile Pro 
785                 790                 795                 800 


Ser Val Leu His Asp Val Glu Thr Val Phe Asp Ala Lys Leu Leu Ser 
                805                 810                 815     


Gln Leu Leu Tyr Glu Phe Tyr Thr Cys Ile Pro Pro Val Lys Leu Gln 
            820                 825                 830         


Lys Gln Lys Val Gln Ser Met Asn Glu Ile Val Gln Ser Asn Leu Phe 
        835                 840                 845             


Lys Lys Gln Glu Cys Arg Asp Ile Leu Leu Pro Val Ile Thr Lys Glu 
    850                 855                 860                 


Leu Lys Glu Leu Leu Glu Gln Arg Asp Asp Gly Gln His Gln Ala Glu 
865                 870                 875                 880 


Lys Lys His Cys Val Glu Leu Leu Asn Ser Ile Leu Glu Val Leu Ser 
                885                 890                 895     


Cys Gln Asp Ala Ala Phe Thr Tyr Asp His Ile Gln Glu Ile Met Val 
            900                 905                 910         


Gln Leu Leu Arg Thr Val Asn Arg Thr Val Ile Thr Met Gly Arg Asp 
        915                 920                 925             


His Ala Leu Ile Ser His Phe Val Ala Cys Met Thr Ala Ile Leu Asp 
    930                 935                 940                 


Gln Met Gly Asp Gln His Tyr Ser Phe Tyr Ile Glu Thr Phe Gln Thr 
945                 950                 955                 960 


Ser Ser Asp Leu Val Asp Phe Leu Met Glu Thr Phe Ile Met Phe Lys 
                965                 970                 975     


Asp Leu Ile Gly Lys Asn Val Tyr Pro Gly Asp Trp Met Ala Met Ser 
            980                 985                 990         


Met Val Gln Asn Arg Val Phe Leu  Arg Ala Ile Asn Lys  Phe Ala Glu 
        995                 1000                 1005             


Thr Met  Asn Gln Lys Phe Leu  Glu His Thr Ser Phe  Glu Phe Gln 
    1010                 1015                 1020             


Leu Trp  Asn Asn Tyr Phe His  Leu Ala Val Ala Phe  Ile Thr Gln 
    1025                 1030                 1035             


Asp Ser  Leu Gln Leu Glu Gln  Phe Thr His Ala Lys  Tyr Asn Lys 
    1040                 1045                 1050             


Ile Leu  Asn Lys Tyr Gly Asp  Met Arg Arg Leu Ile  Gly Phe Ser 
    1055                 1060                 1065             


Ile Arg  Asp Met Trp Tyr Lys  Leu Gly Gln Asn Lys  Ile Cys Phe 
    1070                 1075                 1080             


Ile Pro  Gly Met Val Gly Pro  Ile Leu Glu Met Thr  Leu Ile Pro 
    1085                 1090                 1095             


Glu Ala  Glu Leu Arg Lys Ala  Thr Ile Pro Ile Phe  Phe Asp Met 
    1100                 1105                 1110             


Met Leu  Cys Glu Tyr Gln Arg  Thr Gly Ala Phe Lys  Lys Phe Glu 
    1115                 1120                 1125             


Asn Glu  Ile Ile Leu Lys Leu  Asp His Glu Val Glu  Gly Gly Arg 
    1130                 1135                 1140             


Gly Asp  Glu Gln Tyr Met Gln  Leu Leu Glu Ser Ile  Leu Met Glu 
    1145                 1150                 1155             


Cys Thr  Ala Glu His Pro Thr  Ile Ala Lys Ser Val  Glu Asn Phe 
    1160                 1165                 1170             


Val Ser  Leu Val Lys Gly Leu  Leu Glu Lys Leu Leu  Asp Tyr Arg 
    1175                 1180                 1185             


Gly Val  Met Thr Asp Glu Ser  Lys Asp Asn Arg Met  Ser Cys Thr 
    1190                 1195                 1200             


Val Asn  Leu Leu Asn Phe Tyr  Lys Asp Asn Asn Arg  Glu Glu Met 
    1205                 1210                 1215             


Tyr Ile  Arg Tyr Leu Tyr Lys  Leu Arg Asp Leu His  Leu Asp Cys 
    1220                 1225                 1230             


Glu Asn  Tyr Thr Glu Ala Ala  Tyr Thr Leu Leu Leu  His Thr Trp 
    1235                 1240                 1245             


Leu Leu  Lys Trp Ser Asp Glu  Gln Cys Ala Ser Gln  Val Met Gln 
    1250                 1255                 1260             


Thr Gly  Gln Gln His Pro Gln  Thr His Arg Gln Leu  Lys Glu Thr 
    1265                 1270                 1275             


Leu Tyr  Glu Thr Ile Ile Gly  Tyr Phe Asp Lys Gly  Lys Met Trp 
    1280                 1285                 1290             


Glu Glu  Ala Ile Ser Leu Cys  Lys Glu Leu Ala Glu  Gln Tyr Glu 
    1295                 1300                 1305             


Met Glu  Ile Phe Asp Tyr Glu  Leu Leu Ser Gln Asn  Leu Thr Gln 
    1310                 1315                 1320             


Gln Ala  Lys Phe Tyr Glu Asn  Ile Met Lys Ile Leu  Arg Thr Lys 
    1325                 1330                 1335             


Pro Asp  Tyr Phe Ala Val Gly  Tyr Tyr Gly Gln Gly  Phe Pro Ser 
    1340                 1345                 1350             


Phe Leu  Arg Asn Lys Val Phe  Ile Tyr Arg Gly Lys  Glu Tyr Glu 
    1355                 1360                 1365             


Arg Arg  Glu Asp Phe Gln Met  Gln Leu Leu Ser Gln  Phe Pro Asn 
    1370                 1375                 1380             


Ala Glu  Lys Met Asn Thr Thr  Ser Ala Pro Gly Asp  Asp Val Arg 
    1385                 1390                 1395             


Asn Ala  Pro Gly Gln Tyr Ile  Gln Cys Phe Thr Val  Gln Pro Val 
    1400                 1405                 1410             


Leu Asp  Glu His Pro Arg Phe  Lys Asn Lys Pro Val  Pro Asp Gln 
    1415                 1420                 1425             


Ile Ile  Asn Phe Tyr Lys Ser  Asn Tyr Val Gln Lys  Phe His Tyr 
    1430                 1435                 1440             


Ser Arg  Pro Val Arg Arg Gly  Lys Val Asp Pro Glu  Asn Glu Phe 
    1445                 1450                 1455             


Ala Ser  Met Trp Ile Glu Arg  Thr Ser Phe Leu Thr  Ala Tyr Lys 
    1460                 1465                 1470             


Leu Pro  Gly Ile Leu Arg Trp  Phe Glu Val Val His  Met Ser Gln 
    1475                 1480                 1485             


Thr Thr  Ile Ser Pro Leu Glu  Asn Ala Ile Glu Thr  Met Ser Thr 
    1490                 1495                 1500             


Val Asn  Glu Lys Ile Leu Met  Met Ile Asn Gln Tyr  Gln Ser Asp 
    1505                 1510                 1515             


Glu Ser  Leu Pro Ile Asn Pro  Leu Ser Met Leu Leu  Asn Gly Ile 
    1520                 1525                 1530             


Val Asp  Pro Ala Val Met Gly  Gly Phe Ala Lys Tyr  Glu Lys Ala 
    1535                 1540                 1545             


Phe Phe  Thr Glu Glu Tyr Ser  Arg Glu His Pro Glu  Asp Gln Asp 
    1550                 1555                 1560             


Lys Leu  Ser His Leu Lys Asp  Leu Ile Ala Trp Gln  Ile Pro Phe 
    1565                 1570                 1575             


Leu Gly  Ala Gly Ile Lys Ile  His Glu Lys Arg Val  Ser Asp Asn 
    1580                 1585                 1590             


Leu Arg  Pro Phe His Asp Arg  Met Glu Glu Cys Phe  Lys Asn Leu 
    1595                 1600                 1605             


Lys Met  Lys Val Glu Lys Glu  Tyr Gly Val Arg Glu  Met Pro Asp 
    1610                 1615                 1620             


Phe Glu  Asp Arg Arg Val Gly  Arg Pro Arg Ser Met  Leu Arg Ser 
    1625                 1630                 1635             


Tyr Arg  Gln Met Ser Val Ile  Ser Leu Ala Ser Met  His Ser Asp 
    1640                 1645                 1650             


Cys Ser  Thr Pro Ser Lys Val  Pro Ala Glu Ser Phe  Asp Leu Glu 
    1655                 1660                 1665             


Ser Ala  Pro Pro Lys Thr Pro  Lys Val Glu Glu Glu  Pro Ile Ser 
    1670                 1675                 1680             


Pro Gly  Ser Thr Leu Pro Glu  Val Lys Leu Arg Arg  Ser Lys Lys 
    1685                 1690                 1695             


Arg Thr  Lys Arg Ser Ser Val  Val Phe Ala Asp Glu  Lys Ala Ala 
    1700                 1705                 1710             


Thr Glu  Ser Asp Leu Lys Arg  Leu Ser Arg Lys Gln  Glu Phe Met 
    1715                 1720                 1725             


Ser Asp  Thr Asn Leu Ser Glu  His Ala Ala Ile Pro  Ala Arg Val 
    1730                 1735                 1740             


Ser Ile  Leu Ser Gln Met Ser  Phe Ala Ser Gln Ser  Met Pro Thr 
    1745                 1750                 1755             


Ile Pro  Ala Leu Thr Leu Ser  Val Ala Gly Val Pro  Gly Leu Asp 
    1760                 1765                 1770             


Glu Ala  Asn Thr Ser Pro Arg  Leu Ser Gln Thr Phe  Phe Gln Val 
    1775                 1780                 1785             


Ser Asp  Gly Asp Lys Lys Thr  Leu Lys Lys Lys Lys  Val Asn Gln 
    1790                 1795                 1800             


Phe Phe  Lys Thr Met Leu Ala  Ser Lys Ser Ser Glu  Glu Ser Lys 
    1805                 1810                 1815             


Gln Ile  Pro Asp Phe Leu Ser  Thr Asn Met 
    1820                 1825             


<210> 165
<211> 6431
<212> DNA
<213> Mus musculus

<400> 165
agtggggccc tgcaaggcgc ctaaccaccc cagccagctt cttcactaga gaacaggagg       60

ctctcaaggc tccggtcttg ccatggcccc ctggcgcaaa actgacaagg agcgtcacgg      120

agtggctatc tacaacttcc aaggcagtga agcccagcat ctcacgctac agattggcga      180

tgtggtacga atacaggaga cctgtggaga ctggtacaga gggtacctca taaagcataa      240

actgtcacag ggcattttcc ctacatcctt tatccatctc aaggaagtga cagtggagaa      300

gagaaggaac atagagaaca tcattcctgc agaaatccct ctggcacaag aagtgacaac      360

cacgctctgg gagtggggaa gcatctggaa gcagctctat gtggccagca aaaaggaacg      420

cttcctccaa gtgcagtcca tgatgtacga cctgatggaa tggcgctctc agctcctctc      480

aggaacgcta cccaaggatg agctgaagga actgaagcag aaagtcacat cgaagatcga      540

ctatggcaac aaaatccttg agctcgatct cattgtcaga gatgaagatg gaaacatact      600

ggaccctgat aagaccagcg tcatcagctt gttccatgct cacgaggagg caacttacaa      660

aatcacagag cgcatcaaag aagaaatgtc aaaagaccag ccagattatg gggtttattc      720

tcggatctcc tcatccccca cccacagcct ctacgtcttt gtgagaaact ttgtgtgccg      780

aattggggag gatgctgagc tcttcatgtc tctctatgac cctcacaagc aaacggtcat      840

cagtgagaac tatctggtgc gatggggcag caaaggattc ccaaaggaaa ttgagatgct      900

caataacctg aaggtagtct tcacggatct tggaaataaa gacctcaaca gggataagat      960

tttcttgatc tgtcaaatag tccgaattgg gaagatggat cttaaggaca ttaatgccaa     1020

gaagtgcacc caggggctga ggagaccttt tggggtggca gttatggaca tcaccgacat     1080

catcaagggc aaggcagaga gcgacgaaga gaagcaacat tttattccat ttcacccggt     1140

ctcagctgag aacgatttcc ttcacagcct tctgggcaaa gtcatagctt ccaagggaga     1200

cagtggaggg caaggccttt gggtgaccat gaagatgctg gtgggggaca tcattcagat     1260

ccgtaaagac tacccacact tggtggacag gaccactgtg gtagcccgaa agctgggctt     1320

cccagagatc atcatgccag gggatgtcag gaacgacatc tacatcactc tcttacaagg     1380

tgactttgac aagtacacca agaccacaca gcggaacgtg gaagtgatca tgtgtgtgtg     1440

cacagaggat ggcaaagtgc tacctaatgc aatttgtgtg ggagcggggg ataaggccat     1500

gaacgagtac cactcagtcg tctactacca agtcaaacag ccccgatgga tggaaacagt     1560

caaggtggct gtccctattg aagatatgca gaggatccat ttgaggttca tgtttcgaca     1620

ccgctcatca ctagaatcta aagataaagg agaaaagaac tttgccatgt cctacgtgaa     1680

actcatgaaa gaagatggaa ccactctgca tgatggatac cacgagttgg tggttctcaa     1740

gggagacagc aagaaaatgg aagatgccag cgcttacctg acacttcctt cttatcgaca     1800

ccccgtggaa aacaagggag ctacgctgag ccggagctcc agcagtgttg ggggcctttc     1860

tgtcagctcc cgggatgtgt tctccatttc cacgctagtg tgctccacaa agctgaccca     1920

gaatgtgggt ttgcttggct tgctgaagtg gcgtatgaag ccacaactgc tccaggagaa     1980

tctagagaag ttgaagattg tggatggcga ggaagtagtg aagttcctcc aggacactct     2040

ggatgccctc ttcaacatca tgatggaaca ctctcagagt aacgagtatg acatcctcgt     2100

ctttgatgct ttgatctata taataggact cattgcagac cggaaattcc agcattttaa     2160

caccgtattg gaggcttaca tccaacagca tttcagtgct accttggcct acaagaaact     2220

gatgacggtg ctgaagactt acttggatac ctccagcagg ggggagcagt gcgagcccat     2280

cctcagaacg ctcaaagcct tagaatacgt gttcaagttc attgttcggt cgaggacatt     2340

attctcacag ctttacgaag gcaaagagca gatggagttt gaagaatcca tgagacggct     2400

cttcgaatcc atcaacaacc tgatgaaaag tcagtacaag accaccatcc tattgcaggt     2460

ggcggctttg aaatacatcc cttcagtcct tcacgatgtg gaaacagtct ttgatgccaa     2520

gttgctcagc cagctactgt atgagttcta cacctgcatc cctcccgtga agctgcagaa     2580

gcagaaagtt cagtccatga atgagatcgt gcagagcaac ctcttcaaaa agcaagaatg     2640

ccgggacatt ctgcttcctg tcatcaccaa agagctgaag gagctgctgg agcagaggga     2700

cgatgggcag caccaggctg agaagaagca ctgtgtggaa cttctcaaca gcatcttgga     2760

ggtcctcagc tgtcaggatg cggccttcac ttatgaccac atccaagaga tcatggtcca     2820

gctgcttcgc acagtgaacc ggacagtcat cacgatgggc cgagatcacg ctttgattag     2880

tcactttgtg gcgtgtatga cagctatctt agaccagatg ggcgaccaac actattcatt     2940

ttacattgag accttccaga ccagctcaga ccttgtggac ttcttgatgg agacattcat     3000

catgttcaag gacctcattg ggaagaatgt gtatcctggg gactggatgg ccatgagcat     3060

ggtccagaac cgggtcttcc tgagagccat caacaagttt gcagaaacca tgaaccagaa     3120

gtttctggaa cacacaagct ttgagttcca gctgtggaac aactattttc atctggcagt     3180

tgcctttatc actcaggact ctctgcagct ggagcagttc acacacgcta agtacaacaa     3240

aatcctgaat aagtacgggg acatgagacg gctcatagga ttctccatcc gtgatatgtg     3300

gtacaagctt ggccagaaca aaatctgctt catcccgggc atggtgggac ctatattaga     3360

gatgacactt atccctgagg ctgagctcag gaaagccacc atcccaatct tcttcgacat     3420

gatgctgtgt gaatatcaaa ggactggggc tttcaaaaag tttgaaaatg aaatcatcct     3480

gaagctggac catgaggtgg aaggaggccg gggggatgag cagtacatgc aactgctgga     3540

gtccatcctg atggagtgca cagcggaaca cccaaccatt gccaagtcgg tggagaactt     3600

tgtgagcttg gtcaaagggc tgctggagaa gttgctagat taccggggcg tgatgacaga     3660

tgagagcaaa gacaaccgta tgagctgcac agtgaacttg ctgaatttct acaaagataa     3720

caaccgggaa gagatgtaca taagatacct gtataaactg cgtgaccttc acttggactg     3780

tgaaaactac acagaggctg cctacacact cctcctccac acctggcttc tcaagtggtc     3840

agatgagcag tgtgcatccc aggtcatgca gacaggccag cagcaccctc agacccaccg     3900

gcagctgaag gagacactct atgagaccat tataggctac tttgacaaag gaaagatgtg     3960

ggaagaggcc atcagcctgt gcaaggaact ggcggaacaa tatgagatgg agatctttga     4020

ctacgagcta ctcagccaga acctgaccca gcaggccaaa ttctatgaaa acatcatgaa     4080

aatcctcaga accaaaccag actactttgc tgttggatac tatggccagg gattcccctc     4140

ctttctgcgg aacaaagtgt tcatctaccg aggcaaggaa tatgagcgaa gagaagactt     4200

ccagatgcag cttttgagcc agttccccaa cgcagaaaag atgaacacaa cttctgcccc     4260

aggagacgat gtgaggaatg ccccaggcca gtacatccag tgtttcactg tgcagcctgt     4320

tctggatgaa caccccaggt tcaagaacaa accggtgcct gaccagatca taaactttta     4380

caagtctaat tatgtgcaaa agttccacta ctccaggcct gtgcgcaggg gcaaggtaga     4440

cccagagaac gagtttgctt ccatgtggat cgagaggact tccttcctga cggcctacaa     4500

gctgcctggc atcctgcgct ggtttgaggt agttcacatg tctcagacca caattagtcc     4560

tctggagaat gccatcgaga ctatgtccac agtcaacgag aagatcctga tgatgataaa     4620

ccagtaccag agtgatgaaa gcctccccat caaccctctc tccatgctcc tcaatgggat     4680

cgtggaccct gctgtcatgg gaggcttcgc caagtatgag aaggccttct tcactgaaga     4740

gtatagcagg gagcacccgg aggaccagga caagctgagc catctcaagg acctgattgc     4800

atggcagatc cctttcctgg gagctgggat taagatccac gagaaaaggg tgtcagacaa     4860

cctgcgcccc ttccatgacc ggatggagga gtgcttcaag aacctgaaaa tgaaggtgga     4920

aaaggagtat ggtgtccgag agatgcctga cttcgaagac aggagagtgg gccgccccag     4980

gtccatgctg cgttcctaca ggcagatgtc cgtcatctct ctggcctcca tgcattctga     5040

ctgcagcact cccagcaaag tccccgcaga aagttttgac ctagagtcag ccccacccaa     5100

gactcccaaa gtggaggagg agcccatctc cccagggagc actctgccag aggtcaagct     5160

gcggcggtcc aagaaaagga ccaagaggag cagcgtggtg tttgcagacg agaaggcagc     5220

aacggagtca gacctgaagc ggctttctag aaagcaagag ttcatgagtg acaccaacct     5280

ctcagagcat gcagccatcc ctgccagggt gtctatcctc tctcagatga gttttgccag     5340

ccagtccatg cccaccatcc cagccctcac actctccgtg gcaggcgtgc ctgggttgga     5400

tgaggccaac acatctcccc gcctgagtca gaccttcttc caagtctcag atggtgacaa     5460

gaagaccctg aaaaagaaga aagtcaatca attcttcaag accatgctgg ctagcaagtc     5520

gagtgaagaa agcaagcaga tcccagactt cctgtccacc aacatgtgag gcactgctga     5580

gccgagcact gtgggaactc gagcgggaat gcatgagtat gaccttggag ttccacaagg     5640

agacaagtct gtaaaagaga cagatgatct caaggggccc ccagaactca agtgatgact     5700

agccttgcat ctcctgtggc cactacaaca gtgatggatg actcaacaga caaagaagcc     5760

ccaccatgga ttgttggacc ccaaggagcc agcaagtgcc caatgaatgt tctccccagc     5820

atccaaggga cgcatgtcat aactcaaatt cacagctagg aggagctgtc ttctgtttca     5880

ttcctaagtg tcagcactta aaagaactga tttaaatgtt ctattttccc ttaacatttt     5940

tgtactttta catttttttt ctaataagcc ccttgctact ccatcatctc cagactgctg     6000

ctctttctta cccacattaa aaatgaccca tagctcaaat gaaccttgtt gctgagtctc     6060

ttattgaagg actgaggaga aagatcccag gatgggaggc agcccagggg actacagcaa     6120

tatgaaaggc ttatgttggc tcatctcaat gccatgtttt ctctccttgc tcaggcaaac     6180

tcaagaatct tctctgctct aagaaagaag caggaatgag atttcttcta atttctccat     6240

tgtttagtta ttttgatttg agatacttta ctgatataca agctatttaa actatttggg     6300

gaaaaaagca atgtttgaga tagctaatat aatggcttct caatggaatg atagcacaat     6360

ttgaaatgat accaaaaaga ataataaaat gaaccgtttg aggtttgctt aaaaaaaaaa     6420

aaaaaaaaaa a                                                          6431


<210> 166
<211> 1572
<212> DNA
<213> Homo sapiens

<400> 166
gaggacagac tgaagaaaca tccaaggtgg tcttgaagga cactgggatc ctgtaacaca       60

gccccggata tctgtgttac cagccttgtc tcggccacct caaggataat cactaaattc      120

tgccgaaagg actgaggaac ggtgcctgga aaagggcaag aatatcacgg catgggcatg      180

agtagcttga aactgctgaa gtatgtcctg tttttcttca acttgctctt ttggatctgt      240

ggctgctgca ttttgggctt tgggatctac ctgctgatcc acaacaactt cggagtgctc      300

ttccataacc tcccctccct cacgctgggc aatgtgtttg tcatcgtggg ctctattatc      360

atggtagttg ccttcctggg ctgcatgggc tctatcaagg aaaacaagtg tctgcttatg      420

tcgttcttca tcctgctgct gattatcctc cttgctgagg tgaccttggc catcctgctc      480

tttgtatatg aacagaagct gaatgagtat gtggctaagg gtctgaccga cagcatccac      540

cgttaccact cagacaatag caccaaggca gcgtgggact ccatccagtc atttctgcag      600

tgttgtggta taaatggcac gagtgattgg accagtggcc caccagcatc ttgcccctca      660

gatcgaaaag tggagggttg ctatgcgaaa gcaagactgt ggtttcattc caatttcctg      720

tatatcggaa tcatcaccat ctgtgtatgt gtgattgagg tgttggggat gtcctttgca      780

ctgaccctga actgccagat tgacaaaacc agccagacca tagggctatg atctgcagta      840

gtcctgtggt gaagagactt gtttcatctc cggaaatgca aaaccattta tagcatgaag      900

ccctacatga tcactgcagg atgatcctcc tcccatcctt tcccttttta ggtccctgtc      960

ttatacaacc agagaagtgg gtgttggcca ggcacatccc atctcaggca gcaagacaat     1020

ctttcactca ctgacggcag cagccatgtc tctcaaagtg gtgaaactaa tatctgagca     1080

tcttttagac aagagaggca aagacaaact ggatttaatg gcccaacatc aaagggtgaa     1140

cccaggatat gaatttttgc atcttcccat tgtcgaatta gtctccagcc tctaaataat     1200

gcccagtctt ctccccaaag tcaagcaaga gactagttga agggagttct ggggccaggc     1260

tcactggacc attgtcacaa ccctctgttt ctctttgact aagtgccctg gctacaggaa     1320

ttacacagtt ctctttctcc aaagggcaag atctcatttc aatttcttta ttagagggcc     1380

ttattgatgt gttctaagtc tttccagaaa aaaactatcc agtgatttat atcctgattt     1440

caaccagtca cttagctgat aatcacagta agaagacttc tggtattatc tctctatcag     1500

ataagatttt gttaatgtac tattttactc ttcaataaat aaaagtttat tatctcaatc     1560

acaacattgc ta                                                         1572


<210> 167
<211> 219
<212> PRT
<213> Homo sapiens

<400> 167
Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
    210                 215                 


<210> 168
<211> 1567
<212> DNA
<213> Homo sapiens

<400> 168
gtcgtcacag catgatcata ttttttcacc cttcacttct ccttttacac aaatagcccc       60

ggatatctgt gttaccagcc ttgtctcggc cacctcaagg ataatcacta aattctgccg      120

aaaggactga ggaacggtgc ctggaaaagg gcaagaatat cacggcatgg gcatgagtag      180

cttgaaactg ctgaagtatg tcctgttttt cttcaacttg ctcttttgga tctgtggctg      240

ctgcattttg ggctttggga tctacctgct gatccacaac aacttcggag tgctcttcca      300

taacctcccc tccctcacgc tgggcaatgt gtttgtcatc gtgggctcta ttatcatggt      360

agttgccttc ctgggctgca tgggctctat caaggaaaac aagtgtctgc ttatgtcgtt      420

cttcatcctg ctgctgatta tcctccttgc tgaggtgacc ttggccatcc tgctctttgt      480

atatgaacag aagctgaatg agtatgtggc taagggtctg accgacagca tccaccgtta      540

ccactcagac aatagcacca aggcagcgtg ggactccatc cagtcatttc tgcagtgttg      600

tggtataaat ggcacgagtg attggaccag tggcccacca gcatcttgcc cctcagatcg      660

aaaagtggag ggttgctatg cgaaagcaag actgtggttt cattccaatt tcctgtatat      720

cggaatcatc accatctgtg tatgtgtgat tgaggtgttg gggatgtcct ttgcactgac      780

cctgaactgc cagattgaca aaaccagcca gaccataggg ctatgatctg cagtagtcct      840

gtggtgaaga gacttgtttc atctccggaa atgcaaaacc atttatagca tgaagcccta      900

catgatcact gcaggatgat cctcctccca tcctttccct ttttaggtcc ctgtcttata      960

caaccagaga agtgggtgtt ggccaggcac atcccatctc aggcagcaag acaatctttc     1020

actcactgac ggcagcagcc atgtctctca aagtggtgaa actaatatct gagcatcttt     1080

tagacaagag aggcaaagac aaactggatt taatggccca acatcaaagg gtgaacccag     1140

gatatgaatt tttgcatctt cccattgtcg aattagtctc cagcctctaa ataatgccca     1200

gtcttctccc caaagtcaag caagagacta gttgaaggga gttctggggc caggctcact     1260

ggaccattgt cacaaccctc tgtttctctt tgactaagtg ccctggctac aggaattaca     1320

cagttctctt tctccaaagg gcaagatctc atttcaattt ctttattaga gggccttatt     1380

gatgtgttct aagtctttcc agaaaaaaac tatccagtga tttatatcct gatttcaacc     1440

agtcacttag ctgataatca cagtaagaag acttctggta ttatctctct atcagataag     1500

attttgttaa tgtactattt tactcttcaa taaataaaag tttattatct caatcacaac     1560

attgcta                                                               1567


<210> 169
<211> 160
<212> PRT
<213> Homo sapiens

<400> 169
Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Gly Cys Tyr 
            100                 105                 110         


Ala Lys Ala Arg Leu Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile 
        115                 120                 125             


Ile Thr Ile Cys Val Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala 
    130                 135                 140                 


Leu Thr Leu Asn Cys Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
145                 150                 155                 160 


<210> 170
<211> 1390
<212> DNA
<213> Homo sapiens

<400> 170
gtcgtcacag catgatcata ttttttcacc cttcacttct ccttttacac aaatagcccc       60

ggatatctgt gttaccagcc ttgtctcggc cacctcaagg ataatcacta aattctgccg      120

aaaggactga ggaacggtgc ctggaaaagg gcaagaatat cacggcatgg gcatgagtag      180

cttgaaactg ctgaagtatg tcctgttttt cttcaacttg ctcttttgga tctgtggctg      240

ctgcattttg ggctttggga tctacctgct gatccacaac aacttcggag tgctcttcca      300

taacctcccc tccctcacgc tgggcaatgt gtttgtcatc gtgggctcta ttatcatggt      360

agttgccttc ctgggctgca tgggctctat caaggaaaac aagtgtctgc ttatgtcgtt      420

cttcatcctg ctgctgatta tcctccttgc tgaggtgacc ttggccatcc tgctctttgt      480

atatgaacag aagggttgct atgcgaaagc aagactgtgg tttcattcca atttcctgta      540

tatcggaatc atcaccatct gtgtatgtgt gattgaggtg ttggggatgt cctttgcact      600

gaccctgaac tgccagattg acaaaaccag ccagaccata gggctatgat ctgcagtagt      660

cctgtggtga agagacttgt ttcatctccg gaaatgcaaa accatttata gcatgaagcc      720

ctacatgatc actgcaggat gatcctcctc ccatcctttc cctttttagg tccctgtctt      780

atacaaccag agaagtgggt gttggccagg cacatcccat ctcaggcagc aagacaatct      840

ttcactcact gacggcagca gccatgtctc tcaaagtggt gaaactaata tctgagcatc      900

ttttagacaa gagaggcaaa gacaaactgg atttaatggc ccaacatcaa agggtgaacc      960

caggatatga atttttgcat cttcccattg tcgaattagt ctccagcctc taaataatgc     1020

ccagtcttct ccccaaagtc aagcaagaga ctagttgaag ggagttctgg ggccaggctc     1080

actggaccat tgtcacaacc ctctgtttct ctttgactaa gtgccctggc tacaggaatt     1140

acacagttct ctttctccaa agggcaagat ctcatttcaa tttctttatt agagggcctt     1200

attgatgtgt tctaagtctt tccagaaaaa aactatccag tgatttatat cctgatttca     1260

accagtcact tagctgataa tcacagtaag aagacttctg gtattatctc tctatcagat     1320

aagattttgt taatgtacta ttttactctt caataaataa aagtttatta tctcaatcac     1380

aacattgcta                                                            1390


<210> 171
<211> 2802
<212> DNA
<213> Mus musculus

<400> 171
agtctcactt cctcactctt ctcgcttggg tttcctgtcg tcacagcatg attgtatttt       60

ttctctcttc acttctcctt ttacacaaat agacatagac ttctgggtta caggctgtgc      120

tggccaccta aaagataatc agtgaattct acctgaagta ctgagggaca ctgccttcaa      180

aagggcatac tatcccagca tgggcatgag cagcctgaaa ttgctgaaat atgttctgtt      240

tatctttaac ttgctttttt gggtctgtgg ctgttgcatt ttgggctttg gcatctattt      300

cctggtccaa aatacctatg gagtactctt ccgtaacctt cccttcctga cacttggcaa      360

cattctggtc attgtgggat ccattatcat ggtagttgcc ttcttgggtt gcatgggctc      420

aatcaaggaa aataagtgcc tgcttatgtc gttctttgtt ctgctgctga ttattctcct      480

tgctgaggtg accatagcca tcctgctctt tgtgtatgaa caaaaactca acactttagt      540

ggctgagggt ctgaatgaca gcatccaaca ttatcactct gacaacagca ctatgaaggc      600

atgggacttc atccagacac aactgcagtg ttgtggtgta aatggctcaa gtgattggac      660

cagtggtcca ccatcttcct gcccatcagg tgcagatgtt cagggttgct ataataaggc      720

aaaatcgtgg tttcactcca atttcttgta tattggaatc attaccatct gtgtatgtgt      780

gatacaggtg ctgggaatgt cctttgcact gacactcaac tgccagattg acaaaacaag      840

ccaggcttta gggctgtgac ttgcaacttc cccctgctta agtgacttat tcctctctag      900

aaagtcaaag catccattcc atgagaactt aaacaattac ctgcctgact ggcattttgg      960

cttcttctta ttccatcttt gactggatct ctgtcttata cacatccact gaagagaata     1020

tttgtcatgg acttcccata tcaagcagaa gacaaacatt aaccaactga tagcagtaac     1080

catatccctt aaagatggtg aaacatacct gggtgttttt ggtttttttt ttttttttac     1140

atacttgggt atttttttta aagagacact gtagcactgg tggcttgaga tccactgcca     1200

gctgctggtg tggttatttc tcagagtact agcctagcaa atgtgagccc ttgagtttag     1260

ccccaaatac tacaaaaaag aggtccaagt ttaaatgtta gtctcctaac aactgtcaaa     1320

tcaatttcta gcctctaaat cttgctactt ccactctaca aagtcacata agagagaagc     1380

tgatggaaat ttttgagtcc cattcattag ataattgaca tactcagttt ccttttgaac     1440

acagtccttg gtaataggaa tcatacagaa atcttttatt tctggaaaat attccaattt     1500

ctttgtctta ttgattttgt tccatccatc catccagaaa agattattcc catcctattg     1560

ttagtcagtc tggtagcctt gaattacatt gccataaaac aacccagaag tattaatatc     1620

tccagtgtgt tagctgataa tcacatccat gtctatgttt tatttctcta ttaaataagg     1680

ttctgttaat gtaccatttt aacctgttaa taaacaaaag tttataatca ctatccatca     1740

aacatttgac tcattctgat atttctgtta caagccaaat atatgttata tttctgtata     1800

acaaattagt tcaaaatgta gtggctaaga acctatatat ttgttttata aattgactga     1860

tttaaagaca gcattttgct atgtagccca ggctgtcttg gaacttacta tatgaccaaa     1920

gatggcacca aactcatgat taccctgctt ttaacttctg aatattagaa ttacagttaa     1980

gtgctactaa gtcagaacaa acatttattg tctgatggct ttatgtaatc aggagtgtgg     2040

aagtagctta gaaaaatgat tatagatagt tgtttcttgc atatagtgat taagtggtca     2100

gccatatctt ccatcatctc atgtctcatt ggaaaattaa tccattgtca tgttctcata     2160

tagttgtaat gaacctcata taatggccac acataagttt atatgggtag tttcgtgaat     2220

aatgagacag gtaagacata aaatgatagg tagcatccaa gacaaaagtc atagcacttt     2280

tataacttaa cccagaaatg atggcatcag ttattctggg tcaaaagttc aatttccacc     2340

cagggcaaaa ttacacaaca ggcatatgac ttctaggaag ttgagatcat tgatggccac     2400

atgagagatt gctaaccatc tcatgcttac tatgtcaaaa aatatggtgt acttgtctat     2460

attatgtata tacataacta tattctataa agtaaaaaat tagaacacat ataatgccta     2520

atttatagaa ctcacaagaa tagaaaataa ttggtttttg ttttagaaat gttctgtaga     2580

attctctgac ttgctttaag gaaaactggt tattttcgtg gtgctctata gggaaaatat     2640

ctattgcatt ttctgagtca tataaagagt catgtattcc tctttgttca gactaacact     2700

tagtggtgac attaccagta agttttcctg cctaatgcct gagctttgtt cttagctcta     2760

ctttgttctt cactcccaat aaaatgttat ggagttctaa gg                        2802


<210> 172
<211> 219
<212> PRT
<213> Mus musculus

<400> 172
Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Ile Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Val Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Phe Leu Val Gln Asn Thr Tyr Gly Val Leu Phe Arg Asn Leu Pro 
        35                  40                  45              


Phe Leu Thr Leu Gly Asn Ile Leu Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Val Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Ile Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Thr 
            100                 105                 110         


Leu Val Ala Glu Gly Leu Asn Asp Ser Ile Gln His Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Met Lys Ala Trp Asp Phe Ile Gln Thr Gln Leu Gln Cys 
    130                 135                 140                 


Cys Gly Val Asn Gly Ser Ser Asp Trp Thr Ser Gly Pro Pro Ser Ser 
145                 150                 155                 160 


Cys Pro Ser Gly Ala Asp Val Gln Gly Cys Tyr Asn Lys Ala Lys Ser 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Gln Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Ala Leu Gly Leu 
    210                 215                 


<210> 173
<211> 2570
<212> DNA
<213> Homo sapiens

<400> 173
ccgccctgct cgtgataagg cacaagcaag ggctgccctg aaggaagctc caaagagaaa       60

ggagggcagg aagcccacgg cccacagggg tgtagcccga gacccacctg cagcccccag      120

cccttgccag gaaagcagca gccgcagcca tggcggggat gaagacagcc tccggggact      180

acatcgactc gtcatgggag ctgcgggtgt ttgtgggaga ggaggaccca gaggccgagt      240

cggtcaccct gcgggtcact ggggagtcgc acatcggcgg ggtgctcctg aagattgtgg      300

agcagatcaa tcgcaagcag gactggtcag accatgctat ttggtgggaa cagaagaggc      360

agtggctgct gcagacccac tggacactgg acaagtacgg gatcctggcc gacgcacgcc      420

tcttctttgg gccccagcac cggcccgtca tccttcggtt gcccaaccgc cgcgcactgc      480

gcctccgtgc cagcttctcc cagcccctct tccaggctgt ggctgccatc tgccgcctcc      540

tcagcatccg gcaccccgag gagctgtccc tgctccgggc tcctgagaag aaggagaaga      600

agaagaaaga gaaggagcca gaggaagagc tctatgactt gagcaaggtt gtcttggctg      660

ggggcgtggc acctgcactg ttccggggga tgccagctca cttctcggac agcgcccaga      720

ctgaggcctg ctaccacatg ctgagccggc cccagccgcc acccgacccc ctcctgctcc      780

agcgtctgcc acggcccagc tccctgtcag acaagaccca gctccacagc aggtggctgg      840

actcgtcgcg gtgtctcatg cagcagggca tcaaggccgg ggacgcactc tggctgcgct      900

tcaagtacta cagcttcttc gatttggatc ccaagacaga ccccgtgcgg ctgacacagc      960

tgtatgagca ggcccggtgg gacctgctgc tggaggagat tgactgcacc gaggaggaga     1020

tgatggtgtt tgccgccctg cagtaccaca tcaacaagct gtcccagagc ggggaggtgg     1080

gggagccggc tggcacagac ccagggctgg acgacctgga tgtggccctg agcaacctgg     1140

aggtgaagct ggaggggtcg gcgcccacag atgtgctgga cagcctcacc accatcccag     1200

agctcaagga ccatctccga atctttcgca tcccacgaag gccccggaag ctgaccctga     1260

agggctaccg ccaacactgg gtggtgttca aggagaccac actgtcctac tacaagagcc     1320

aggacgaggc ccctggggac cccattcagc agctcaacct caagggctgt gaggtggttc     1380

ccgatgttaa cgtctccggc cagaagttct gcattaaact cctagtgccc tcccctgagg     1440

gcatgagtga gatctacctg cggtgccagg atgagcagca gtatgcccgc tggatggctg     1500

gctgccgcct ggcctccaaa ggccgcacca tggccgacag cagctacacc agcgaggtgc     1560

aggccatcct ggccttcctc agcctgcagc gcacgggcag tgggggcccg ggcaaccacc     1620

cccacggccc tgatgcctct gccgagggcc tcaaccccta cggcctcgtt gccccccgtt     1680

tccagcgaaa gttcaaggcc aagcagctca ccccacggat cctggaagcc caccagaatg     1740

tggcccagtt gtcgctggca gaggcccagc tgcgcttcat ccaggcctgg cagtccctgc     1800

ccgacttcgg catctcctat gtcatggtca ggttcaaggg cagcaggaaa gacgagatcc     1860

tgggcatcgc caacaaccga ctgatccgca tcgacttggc cgtgggcgac gtggtcaaga     1920

cctggcgttt cagcaacatg cgccagtgga atgtcaactg ggacatccgg caggtggcca     1980

tcgagtttga tgaacacatc aatgtggcct tcagctgcgt gtctgccagc tgccgaattg     2040

tacacgagta tatcgggggc tacattttcc tgtcgacgcg ggagcgggcc cgtggggagg     2100

agctggatga agacctcttc ctgcagctca ccgggggcca tgaggccttc tgagggctgt     2160

ctgattgccc ctgccctgct caccaccctg tcacagccac tcccaagccc acacccacag     2220

gggctcactg ccccacaccc gctccaggca ggcacccagc tgggcatttc acctgctgtc     2280

actgactttg tgcaggccaa ggacctggca gggccagacg ctgtaccatc acccaggcca     2340

gggatggggg tgggggtccc tgagctcatg tggtgccccc tttccttgtc tgagtggctg     2400

aggctgatac ccctgaccta tctgcagtcc cccagcacac aaggaagacc agatgtagct     2460

acaggatgat gaaacatggt ttcaaacgag ttctttcttg ttacttttta aaatttcttt     2520

tttataaatt aatattttat tgttggatcc tcaaaaaaaa aaaaaaaaaa                2570


<210> 174
<211> 667
<212> PRT
<213> Homo sapiens

<400> 174
Met Ala Gly Met Lys Thr Ala Ser Gly Asp Tyr Ile Asp Ser Ser Trp 
1               5                   10                  15      


Glu Leu Arg Val Phe Val Gly Glu Glu Asp Pro Glu Ala Glu Ser Val 
            20                  25                  30          


Thr Leu Arg Val Thr Gly Glu Ser His Ile Gly Gly Val Leu Leu Lys 
        35                  40                  45              


Ile Val Glu Gln Ile Asn Arg Lys Gln Asp Trp Ser Asp His Ala Ile 
    50                  55                  60                  


Trp Trp Glu Gln Lys Arg Gln Trp Leu Leu Gln Thr His Trp Thr Leu 
65                  70                  75                  80  


Asp Lys Tyr Gly Ile Leu Ala Asp Ala Arg Leu Phe Phe Gly Pro Gln 
                85                  90                  95      


His Arg Pro Val Ile Leu Arg Leu Pro Asn Arg Arg Ala Leu Arg Leu 
            100                 105                 110         


Arg Ala Ser Phe Ser Gln Pro Leu Phe Gln Ala Val Ala Ala Ile Cys 
        115                 120                 125             


Arg Leu Leu Ser Ile Arg His Pro Glu Glu Leu Ser Leu Leu Arg Ala 
    130                 135                 140                 


Pro Glu Lys Lys Glu Lys Lys Lys Lys Glu Lys Glu Pro Glu Glu Glu 
145                 150                 155                 160 


Leu Tyr Asp Leu Ser Lys Val Val Leu Ala Gly Gly Val Ala Pro Ala 
                165                 170                 175     


Leu Phe Arg Gly Met Pro Ala His Phe Ser Asp Ser Ala Gln Thr Glu 
            180                 185                 190         


Ala Cys Tyr His Met Leu Ser Arg Pro Gln Pro Pro Pro Asp Pro Leu 
        195                 200                 205             


Leu Leu Gln Arg Leu Pro Arg Pro Ser Ser Leu Ser Asp Lys Thr Gln 
    210                 215                 220                 


Leu His Ser Arg Trp Leu Asp Ser Ser Arg Cys Leu Met Gln Gln Gly 
225                 230                 235                 240 


Ile Lys Ala Gly Asp Ala Leu Trp Leu Arg Phe Lys Tyr Tyr Ser Phe 
                245                 250                 255     


Phe Asp Leu Asp Pro Lys Thr Asp Pro Val Arg Leu Thr Gln Leu Tyr 
            260                 265                 270         


Glu Gln Ala Arg Trp Asp Leu Leu Leu Glu Glu Ile Asp Cys Thr Glu 
        275                 280                 285             


Glu Glu Met Met Val Phe Ala Ala Leu Gln Tyr His Ile Asn Lys Leu 
    290                 295                 300                 


Ser Gln Ser Gly Glu Val Gly Glu Pro Ala Gly Thr Asp Pro Gly Leu 
305                 310                 315                 320 


Asp Asp Leu Asp Val Ala Leu Ser Asn Leu Glu Val Lys Leu Glu Gly 
                325                 330                 335     


Ser Ala Pro Thr Asp Val Leu Asp Ser Leu Thr Thr Ile Pro Glu Leu 
            340                 345                 350         


Lys Asp His Leu Arg Ile Phe Arg Ile Pro Arg Arg Pro Arg Lys Leu 
        355                 360                 365             


Thr Leu Lys Gly Tyr Arg Gln His Trp Val Val Phe Lys Glu Thr Thr 
    370                 375                 380                 


Leu Ser Tyr Tyr Lys Ser Gln Asp Glu Ala Pro Gly Asp Pro Ile Gln 
385                 390                 395                 400 


Gln Leu Asn Leu Lys Gly Cys Glu Val Val Pro Asp Val Asn Val Ser 
                405                 410                 415     


Gly Gln Lys Phe Cys Ile Lys Leu Leu Val Pro Ser Pro Glu Gly Met 
            420                 425                 430         


Ser Glu Ile Tyr Leu Arg Cys Gln Asp Glu Gln Gln Tyr Ala Arg Trp 
        435                 440                 445             


Met Ala Gly Cys Arg Leu Ala Ser Lys Gly Arg Thr Met Ala Asp Ser 
    450                 455                 460                 


Ser Tyr Thr Ser Glu Val Gln Ala Ile Leu Ala Phe Leu Ser Leu Gln 
465                 470                 475                 480 


Arg Thr Gly Ser Gly Gly Pro Gly Asn His Pro His Gly Pro Asp Ala 
                485                 490                 495     


Ser Ala Glu Gly Leu Asn Pro Tyr Gly Leu Val Ala Pro Arg Phe Gln 
            500                 505                 510         


Arg Lys Phe Lys Ala Lys Gln Leu Thr Pro Arg Ile Leu Glu Ala His 
        515                 520                 525             


Gln Asn Val Ala Gln Leu Ser Leu Ala Glu Ala Gln Leu Arg Phe Ile 
    530                 535                 540                 


Gln Ala Trp Gln Ser Leu Pro Asp Phe Gly Ile Ser Tyr Val Met Val 
545                 550                 555                 560 


Arg Phe Lys Gly Ser Arg Lys Asp Glu Ile Leu Gly Ile Ala Asn Asn 
                565                 570                 575     


Arg Leu Ile Arg Ile Asp Leu Ala Val Gly Asp Val Val Lys Thr Trp 
            580                 585                 590         


Arg Phe Ser Asn Met Arg Gln Trp Asn Val Asn Trp Asp Ile Arg Gln 
        595                 600                 605             


Val Ala Ile Glu Phe Asp Glu His Ile Asn Val Ala Phe Ser Cys Val 
    610                 615                 620                 


Ser Ala Ser Cys Arg Ile Val His Glu Tyr Ile Gly Gly Tyr Ile Phe 
625                 630                 635                 640 


Leu Ser Thr Arg Glu Arg Ala Arg Gly Glu Glu Leu Asp Glu Asp Leu 
                645                 650                 655     


Phe Leu Gln Leu Thr Gly Gly His Glu Ala Phe 
            660                 665         


<210> 175
<211> 2558
<212> DNA
<213> Homo sapiens

<400> 175
ccgccctgct cgtgataagg cacaagcaag ggctgccctg aaggaagctc caaagagaaa       60

ggagggcagg aagcccacgg cccacagggg tgtagcccga gacccacctg cagcccccag      120

cccttgccag gaaagcagca gccgcagcca tggcggggat gaagacagcc tccggggact      180

acatcgactc gtcatgggag ctgcgggtgt ttgtgggaga ggaggaccca gaggccgagt      240

cggtcaccct gcgggtcact ggggagtcgc acatcggcgg ggtgctcctg aagattgtgg      300

agcagatcaa tcgcaagcag gactggtcag accatgctat ttggtgggaa cagaagaggc      360

agtggctgct gcagacccac tggacactgg acaagtacgg gatcctggcc gacgcacgcc      420

tcttctttgg gccccagcac cggcccgtca tccttcggtt gcccaaccgc cgcgcactgc      480

gcctccgtgc cagcttctcc cagcccctct tccaggctgt ggctgccatc tgccgcctcc      540

tcagcatccg gcaccccgag gagctgtccc tgctccgggc tcctgagaag aaggagaaga      600

agaagaaaga gaaggagcca gaggaagagc tctatgactt gagcaaggtt gtcttggctg      660

ggggcgtggc acctgcactg ttccggggga tgccagctca cttctcggac agcgcccaga      720

ctgaggcctg ctaccacatg ctgagccggc cccagccgcc acccgacccc ctcctgctcc      780

agcgtctgcc acggcccagc tccctgtcag acaagaccca gctccacagc aggtggctgg      840

actcgtcgcg gtgtctcatg cagcagggca tcaaggccgg ggacgcactc tggctgcgct      900

tcaagtacta cagcttcttc gatttggatc ccaagacaga ccccgtgcgg ctgacacagc      960

tgtatgagca ggcccggtgg gacctgctgc tggaggagat tgactgcacc gaggaggaga     1020

tgatggtgtt tgccgccctg cagtaccaca tcaacaagct gtcccagagc ggggaggtgg     1080

gggagccggc tggcacagac ccagggctgg acgacctgga tgtggccctg agcaacctgg     1140

aggtgaagct ggaggggtcg gcgcccacag atgtgctgga cagcctcacc accatcccag     1200

agctcaagga ccatctccga atctttcggc cccggaagct gaccctgaag ggctaccgcc     1260

aacactgggt ggtgttcaag gagaccacac tgtcctacta caagagccag gacgaggccc     1320

ctggggaccc cattcagcag ctcaacctca agggctgtga ggtggttccc gatgttaacg     1380

tctccggcca gaagttctgc attaaactcc tagtgccctc ccctgagggc atgagtgaga     1440

tctacctgcg gtgccaggat gagcagcagt atgcccgctg gatggctggc tgccgcctgg     1500

cctccaaagg ccgcaccatg gccgacagca gctacaccag cgaggtgcag gccatcctgg     1560

ccttcctcag cctgcagcgc acgggcagtg ggggcccggg caaccacccc cacggccctg     1620

atgcctctgc cgagggcctc aacccctacg gcctcgttgc cccccgtttc cagcgaaagt     1680

tcaaggccaa gcagctcacc ccacggatcc tggaagccca ccagaatgtg gcccagttgt     1740

cgctggcaga ggcccagctg cgcttcatcc aggcctggca gtccctgccc gacttcggca     1800

tctcctatgt catggtcagg ttcaagggca gcaggaaaga cgagatcctg ggcatcgcca     1860

acaaccgact gatccgcatc gacttggccg tgggcgacgt ggtcaagacc tggcgtttca     1920

gcaacatgcg ccagtggaat gtcaactggg acatccggca ggtggccatc gagtttgatg     1980

aacacatcaa tgtggccttc agctgcgtgt ctgccagctg ccgaattgta cacgagtata     2040

tcgggggcta cattttcctg tcgacgcggg agcgggcccg tggggaggag ctggatgaag     2100

acctcttcct gcagctcacc gggggccatg aggccttctg agggctgtct gattgcccct     2160

gccctgctca ccaccctgtc acagccactc ccaagcccac acccacaggg gctcactgcc     2220

ccacacccgc tccaggcagg cacccagctg ggcatttcac ctgctgtcac tgactttgtg     2280

caggccaagg acctggcagg gccagacgct gtaccatcac ccaggccagg gatgggggtg     2340

ggggtccctg agctcatgtg gtgccccctt tccttgtctg agtggctgag gctgataccc     2400

ctgacctatc tgcagtcccc cagcacacaa ggaagaccag atgtagctac aggatgatga     2460

aacatggttt caaacgagtt ctttcttgtt actttttaaa atttcttttt tataaattaa     2520

tattttattg ttggatcctc aaaaaaaaaa aaaaaaaa                             2558


<210> 176
<211> 663
<212> PRT
<213> Homo sapiens

<400> 176
Met Ala Gly Met Lys Thr Ala Ser Gly Asp Tyr Ile Asp Ser Ser Trp 
1               5                   10                  15      


Glu Leu Arg Val Phe Val Gly Glu Glu Asp Pro Glu Ala Glu Ser Val 
            20                  25                  30          


Thr Leu Arg Val Thr Gly Glu Ser His Ile Gly Gly Val Leu Leu Lys 
        35                  40                  45              


Ile Val Glu Gln Ile Asn Arg Lys Gln Asp Trp Ser Asp His Ala Ile 
    50                  55                  60                  


Trp Trp Glu Gln Lys Arg Gln Trp Leu Leu Gln Thr His Trp Thr Leu 
65                  70                  75                  80  


Asp Lys Tyr Gly Ile Leu Ala Asp Ala Arg Leu Phe Phe Gly Pro Gln 
                85                  90                  95      


His Arg Pro Val Ile Leu Arg Leu Pro Asn Arg Arg Ala Leu Arg Leu 
            100                 105                 110         


Arg Ala Ser Phe Ser Gln Pro Leu Phe Gln Ala Val Ala Ala Ile Cys 
        115                 120                 125             


Arg Leu Leu Ser Ile Arg His Pro Glu Glu Leu Ser Leu Leu Arg Ala 
    130                 135                 140                 


Pro Glu Lys Lys Glu Lys Lys Lys Lys Glu Lys Glu Pro Glu Glu Glu 
145                 150                 155                 160 


Leu Tyr Asp Leu Ser Lys Val Val Leu Ala Gly Gly Val Ala Pro Ala 
                165                 170                 175     


Leu Phe Arg Gly Met Pro Ala His Phe Ser Asp Ser Ala Gln Thr Glu 
            180                 185                 190         


Ala Cys Tyr His Met Leu Ser Arg Pro Gln Pro Pro Pro Asp Pro Leu 
        195                 200                 205             


Leu Leu Gln Arg Leu Pro Arg Pro Ser Ser Leu Ser Asp Lys Thr Gln 
    210                 215                 220                 


Leu His Ser Arg Trp Leu Asp Ser Ser Arg Cys Leu Met Gln Gln Gly 
225                 230                 235                 240 


Ile Lys Ala Gly Asp Ala Leu Trp Leu Arg Phe Lys Tyr Tyr Ser Phe 
                245                 250                 255     


Phe Asp Leu Asp Pro Lys Thr Asp Pro Val Arg Leu Thr Gln Leu Tyr 
            260                 265                 270         


Glu Gln Ala Arg Trp Asp Leu Leu Leu Glu Glu Ile Asp Cys Thr Glu 
        275                 280                 285             


Glu Glu Met Met Val Phe Ala Ala Leu Gln Tyr His Ile Asn Lys Leu 
    290                 295                 300                 


Ser Gln Ser Gly Glu Val Gly Glu Pro Ala Gly Thr Asp Pro Gly Leu 
305                 310                 315                 320 


Asp Asp Leu Asp Val Ala Leu Ser Asn Leu Glu Val Lys Leu Glu Gly 
                325                 330                 335     


Ser Ala Pro Thr Asp Val Leu Asp Ser Leu Thr Thr Ile Pro Glu Leu 
            340                 345                 350         


Lys Asp His Leu Arg Ile Phe Arg Pro Arg Lys Leu Thr Leu Lys Gly 
        355                 360                 365             


Tyr Arg Gln His Trp Val Val Phe Lys Glu Thr Thr Leu Ser Tyr Tyr 
    370                 375                 380                 


Lys Ser Gln Asp Glu Ala Pro Gly Asp Pro Ile Gln Gln Leu Asn Leu 
385                 390                 395                 400 


Lys Gly Cys Glu Val Val Pro Asp Val Asn Val Ser Gly Gln Lys Phe 
                405                 410                 415     


Cys Ile Lys Leu Leu Val Pro Ser Pro Glu Gly Met Ser Glu Ile Tyr 
            420                 425                 430         


Leu Arg Cys Gln Asp Glu Gln Gln Tyr Ala Arg Trp Met Ala Gly Cys 
        435                 440                 445             


Arg Leu Ala Ser Lys Gly Arg Thr Met Ala Asp Ser Ser Tyr Thr Ser 
    450                 455                 460                 


Glu Val Gln Ala Ile Leu Ala Phe Leu Ser Leu Gln Arg Thr Gly Ser 
465                 470                 475                 480 


Gly Gly Pro Gly Asn His Pro His Gly Pro Asp Ala Ser Ala Glu Gly 
                485                 490                 495     


Leu Asn Pro Tyr Gly Leu Val Ala Pro Arg Phe Gln Arg Lys Phe Lys 
            500                 505                 510         


Ala Lys Gln Leu Thr Pro Arg Ile Leu Glu Ala His Gln Asn Val Ala 
        515                 520                 525             


Gln Leu Ser Leu Ala Glu Ala Gln Leu Arg Phe Ile Gln Ala Trp Gln 
    530                 535                 540                 


Ser Leu Pro Asp Phe Gly Ile Ser Tyr Val Met Val Arg Phe Lys Gly 
545                 550                 555                 560 


Ser Arg Lys Asp Glu Ile Leu Gly Ile Ala Asn Asn Arg Leu Ile Arg 
                565                 570                 575     


Ile Asp Leu Ala Val Gly Asp Val Val Lys Thr Trp Arg Phe Ser Asn 
            580                 585                 590         


Met Arg Gln Trp Asn Val Asn Trp Asp Ile Arg Gln Val Ala Ile Glu 
        595                 600                 605             


Phe Asp Glu His Ile Asn Val Ala Phe Ser Cys Val Ser Ala Ser Cys 
    610                 615                 620                 


Arg Ile Val His Glu Tyr Ile Gly Gly Tyr Ile Phe Leu Ser Thr Arg 
625                 630                 635                 640 


Glu Arg Ala Arg Gly Glu Glu Leu Asp Glu Asp Leu Phe Leu Gln Leu 
                645                 650                 655     


Thr Gly Gly His Glu Ala Phe 
            660             


<210> 177
<211> 2590
<212> DNA
<213> Mus musculus

<400> 177
gtggagccct ctgcgtgctg gcagtgtgct tcctgtaccc agcaacagcc cgccctgggg       60

agggactagt acaactttca tgataaggcc actacaggct gacctctgaa ggaagcaact      120

gagcaggacc aggccagacc agggtaacag gtgtcccact gccacctgca gctgcagccc      180

gttgcaggct agcagaaaca gccgcagcca tggcgggtat gaagacagcc tccggggact      240

atatcgactc ttcctgggag ctgagggtgt ttgtgggcga ggaggaccct gaggcccagt      300

ctgtcacact ccgagtcacg ggggagtcgc acattggtgg ggtacttctg aagatcgtgg      360

aggaaatcaa tcgcaagcag gactggtctg accatgccat ttggtgggag cagaagagac      420

agtggctgct gcagacacac tggacgctgg acaagtacgg gattctggcc gatgcccgcc      480

tcttctttgg gccacagcac cgacctgtca tcctgcgact gcccaacaga cgtgtgctgc      540

ggcttcgggc cagtttctcc aagcccctct tccaaacggt ggctgccatc tgccgcctcc      600

tcagtatcag gcacccagag gagctgtctc tgctgcgtgc tccagagaag aaggagaaga      660

agaagaagga gaaggagcct gaagaggagg tgcatgacct gacaaaggtt gtcttagctg      720

gcggtgtggc acccacttta ttcagaggca tgccagcaca cttctcggac agcgcccaga      780

ctgaggcttg ttaccacatg ctgagccggc cacagccggc acctgaccct ctcctgctcc      840

agcgcctgcc aaggcccagc tccctgcctg acaagaccca gctccacagc aggtggctgg      900

attcatctcg gtgcctcatg cagcaaggta tcaaggccgg ggatgtgctt tggctgcgat      960

ttaagtacta cagctttttt gacctggatc ccaagacaga ccctgtgcgg ctgacccagc     1020

tgtatgagca ggcccgctgg gacttactga cagaggagat cgactgcact gaagaagaga     1080

tgatggtgtt tgctgccctg cagtaccaca tcaacaaact gaccctgagc ggggatgtgg     1140

gtgagctggc ctctggggac ctgggactgg atgacctgga tgcagccctg aacaacctgg     1200

aggtgaagct gaaggggtca gcaccctcag acatgctgga tagtctcact accatcccag     1260

aactcaagga ccatctccgg atcttccggc cccggaagct gaccctgaag ggctaccgcc     1320

agtactgggt ggtatttaag gacaccacac tgtcctacta taagagccaa gatgaagcac     1380

cgggggaccc tacccagcag ctcaacctca agggctgtga ggtggtccct gatgtcaatg     1440

tctctggcca gaagttctgc atcaaactcc tggtaccctc accagagggc atgagtgaga     1500

tctacctgag gtgccaggat gaacagcagt acgcacagtg gatggctgcc tgccgactgg     1560

cctccaaggg ccgcaccatg gcggacagca gctatgccag cgaggtgcag gccattctgg     1620

ccttcctcag cctgcagcgg gcaggtggta gcaatggagg ctcagggaac aaacctcaag     1680

gtcctgaagc ccctgctgag ggccttaacc cctatggcct cgtggctcct cggttccagc     1740

gaaagttcaa ggccaagcag ctcaccccaa ggatcctgga agctcaccaa aacgtggccc     1800

aactctcact gaccgaggcc cagctgcgct ttatccaggc ctggcaatcc ttgcccgact     1860

ttggcatctc ctatgtgatg gtcaggttca agggcagcag gaaagatgag atcctaggca     1920

ttgccaacaa ccgactcatc cggattgatc tggccgtggg tgacgtggtc aagacctggc     1980

gcttcagcaa catgcggcaa tggaacgtca actgggacat acggcaggtg gccattgagt     2040

tcgatgaaca catcaatgtg gccttcagct gtgtgtctgc tagctgccgc atcgtgcacg     2100

agtacatcgg gggttacatc ttcctgtcca cccgagagcg ggcccgaggg gaagagctgg     2160

atgaggatct gttcctgcag cttacaggag gccatgaggc cttctgaggg cagcccctgc     2220

tccactcacc acctccaggg accccccaaa ggccacaccc acctgaacac actgctccat     2280

cactcccggg atgtacactg ctgggcaact tcacttgttg tcaccaggca ggccagggcc     2340

ctcgctgggg taggtgctac caccagccag cctagggatg atgggccctg agccacacag     2400

agcccctcct ctcaccctgt tggcagaagc tcacaccccc gacctctatg tagtccctaa     2460

gcacacgacg aatgccagac acggatgagg aaccacaaat cctggtttga agctggactt     2520

tctttctgtg tctgtttcag gttttttaat aaataaatat tttattgttg gatctttctt     2580

cttcctcctc                                                            2590


<210> 178
<211> 2587
<212> DNA
<213> Mus musculus

<400> 178
gtggagccct ctgcgtgctg gcagtgtgct tcctgtaccc agcaacagcc cgccctgggg       60

agggactagt acaactttca tgataaggcc actacaggct gacctctgaa ggaagcaact      120

gagcaggacc aggccagacc agggtaacag gtgtcccact gccacctgca gctgcagccc      180

gttgcaggct agaaacagcc gcagccatgg cgggtatgaa gacagcctcc ggggactata      240

tcgactcttc ctgggagctg agggtgtttg tgggcgagga ggaccctgag gcccagtctg      300

tcacactccg agtcacgggg gagtcgcaca ttggtggggt acttctgaag atcgtggagg      360

aaatcaatcg caagcaggac tggtctgacc atgccatttg gtgggagcag aagagacagt      420

ggctgctgca gacacactgg acgctggaca agtacgggat tctggccgat gcccgcctct      480

tctttgggcc acagcaccga cctgtcatcc tgcgactgcc caacagacgt gtgctgcggc      540

ttcgggccag tttctccaag cccctcttcc aaacggtggc tgccatctgc cgcctcctca      600

gtatcaggca cccagaggag ctgtctctgc tgcgtgctcc agagaagaag gagaagaaga      660

agaaggagaa ggagcctgaa gaggaggtgc atgacctgac aaaggttgtc ttagctggcg      720

gtgtggcacc cactttattc agaggcatgc cagcacactt ctcggacagc gcccagactg      780

aggcttgtta ccacatgctg agccggccac agccggcacc tgaccctctc ctgctccagc      840

gcctgccaag gcccagctcc ctgcctgaca agacccagct ccacagcagg tggctggatt      900

catctcggtg cctcatgcag caaggtatca aggccgggga tgtgctttgg ctgcgattta      960

agtactacag cttttttgac ctggatccca agacagaccc tgtgcggctg acccagctgt     1020

atgagcaggc ccgctgggac ttactgacag aggagatcga ctgcactgaa gaagagatga     1080

tggtgtttgc tgccctgcag taccacatca acaaactgac cctgagcggg gatgtgggtg     1140

agctggcctc tggggacctg ggactggatg acctggatgc agccctgaac aacctggagg     1200

tgaagctgaa ggggtcagca ccctcagaca tgctggatag tctcactacc atcccagaac     1260

tcaaggacca tctccggatc ttccggcccc ggaagctgac cctgaagggc taccgccagt     1320

actgggtggt atttaaggac accacactgt cctactataa gagccaagat gaagcaccgg     1380

gggaccctac ccagcagctc aacctcaagg gctgtgaggt ggtccctgat gtcaatgtct     1440

ctggccagaa gttctgcatc aaactcctgg taccctcacc agagggcatg agtgagatct     1500

acctgaggtg ccaggatgaa cagcagtacg cacagtggat ggctgcctgc cgactggcct     1560

ccaagggccg caccatggcg gacagcagct atgccagcga ggtgcaggcc attctggcct     1620

tcctcagcct gcagcgggca ggtggtagca atggaggctc agggaacaaa cctcaaggtc     1680

ctgaagcccc tgctgagggc cttaacccct atggcctcgt ggctcctcgg ttccagcgaa     1740

agttcaaggc caagcagctc accccaagga tcctggaagc tcaccaaaac gtggcccaac     1800

tctcactgac cgaggcccag ctgcgcttta tccaggcctg gcaatccttg cccgactttg     1860

gcatctccta tgtgatggtc aggttcaagg gcagcaggaa agatgagatc ctaggcattg     1920

ccaacaaccg actcatccgg attgatctgg ccgtgggtga cgtggtcaag acctggcgct     1980

tcagcaacat gcggcaatgg aacgtcaact gggacatacg gcaggtggcc attgagttcg     2040

atgaacacat caatgtggcc ttcagctgtg tgtctgctag ctgccgcatc gtgcacgagt     2100

acatcggggg ttacatcttc ctgtccaccc gagagcgggc ccgaggggaa gagctggatg     2160

aggatctgtt cctgcagctt acaggaggcc atgaggcctt ctgagggcag cccctgctcc     2220

actcaccacc tccagggacc ccccaaaggc cacacccacc tgaacacact gctccatcac     2280

tcccgggatg tacactgctg ggcaacttca cttgttgtca ccaggcaggc cagggccctc     2340

gctggggtag gtgctaccac cagccagcct agggatgatg ggccctgagc cacacagagc     2400

ccctcctctc accctgttgg cagaagctca cacccccgac ctctatgtag tccctaagca     2460

cacgacgaat gccagacacg gatgaggaac cacaaatcct ggtttgaagc tggactttct     2520

ttctgtgtct gtttcaggtt ttttaataaa taaatatttt attgttggat ctttcttctt     2580

cctcctc                                                               2587


<210> 179
<211> 665
<212> PRT
<213> Mus musculus

<400> 179
Met Ala Gly Met Lys Thr Ala Ser Gly Asp Tyr Ile Asp Ser Ser Trp 
1               5                   10                  15      


Glu Leu Arg Val Phe Val Gly Glu Glu Asp Pro Glu Ala Gln Ser Val 
            20                  25                  30          


Thr Leu Arg Val Thr Gly Glu Ser His Ile Gly Gly Val Leu Leu Lys 
        35                  40                  45              


Ile Val Glu Glu Ile Asn Arg Lys Gln Asp Trp Ser Asp His Ala Ile 
    50                  55                  60                  


Trp Trp Glu Gln Lys Arg Gln Trp Leu Leu Gln Thr His Trp Thr Leu 
65                  70                  75                  80  


Asp Lys Tyr Gly Ile Leu Ala Asp Ala Arg Leu Phe Phe Gly Pro Gln 
                85                  90                  95      


His Arg Pro Val Ile Leu Arg Leu Pro Asn Arg Arg Val Leu Arg Leu 
            100                 105                 110         


Arg Ala Ser Phe Ser Lys Pro Leu Phe Gln Thr Val Ala Ala Ile Cys 
        115                 120                 125             


Arg Leu Leu Ser Ile Arg His Pro Glu Glu Leu Ser Leu Leu Arg Ala 
    130                 135                 140                 


Pro Glu Lys Lys Glu Lys Lys Lys Lys Glu Lys Glu Pro Glu Glu Glu 
145                 150                 155                 160 


Val His Asp Leu Thr Lys Val Val Leu Ala Gly Gly Val Ala Pro Thr 
                165                 170                 175     


Leu Phe Arg Gly Met Pro Ala His Phe Ser Asp Ser Ala Gln Thr Glu 
            180                 185                 190         


Ala Cys Tyr His Met Leu Ser Arg Pro Gln Pro Ala Pro Asp Pro Leu 
        195                 200                 205             


Leu Leu Gln Arg Leu Pro Arg Pro Ser Ser Leu Pro Asp Lys Thr Gln 
    210                 215                 220                 


Leu His Ser Arg Trp Leu Asp Ser Ser Arg Cys Leu Met Gln Gln Gly 
225                 230                 235                 240 


Ile Lys Ala Gly Asp Val Leu Trp Leu Arg Phe Lys Tyr Tyr Ser Phe 
                245                 250                 255     


Phe Asp Leu Asp Pro Lys Thr Asp Pro Val Arg Leu Thr Gln Leu Tyr 
            260                 265                 270         


Glu Gln Ala Arg Trp Asp Leu Leu Thr Glu Glu Ile Asp Cys Thr Glu 
        275                 280                 285             


Glu Glu Met Met Val Phe Ala Ala Leu Gln Tyr His Ile Asn Lys Leu 
    290                 295                 300                 


Thr Leu Ser Gly Asp Val Gly Glu Leu Ala Ser Gly Asp Leu Gly Leu 
305                 310                 315                 320 


Asp Asp Leu Asp Ala Ala Leu Asn Asn Leu Glu Val Lys Leu Lys Gly 
                325                 330                 335     


Ser Ala Pro Ser Asp Met Leu Asp Ser Leu Thr Thr Ile Pro Glu Leu 
            340                 345                 350         


Lys Asp His Leu Arg Ile Phe Arg Pro Arg Lys Leu Thr Leu Lys Gly 
        355                 360                 365             


Tyr Arg Gln Tyr Trp Val Val Phe Lys Asp Thr Thr Leu Ser Tyr Tyr 
    370                 375                 380                 


Lys Ser Gln Asp Glu Ala Pro Gly Asp Pro Thr Gln Gln Leu Asn Leu 
385                 390                 395                 400 


Lys Gly Cys Glu Val Val Pro Asp Val Asn Val Ser Gly Gln Lys Phe 
                405                 410                 415     


Cys Ile Lys Leu Leu Val Pro Ser Pro Glu Gly Met Ser Glu Ile Tyr 
            420                 425                 430         


Leu Arg Cys Gln Asp Glu Gln Gln Tyr Ala Gln Trp Met Ala Ala Cys 
        435                 440                 445             


Arg Leu Ala Ser Lys Gly Arg Thr Met Ala Asp Ser Ser Tyr Ala Ser 
    450                 455                 460                 


Glu Val Gln Ala Ile Leu Ala Phe Leu Ser Leu Gln Arg Ala Gly Gly 
465                 470                 475                 480 


Ser Asn Gly Gly Ser Gly Asn Lys Pro Gln Gly Pro Glu Ala Pro Ala 
                485                 490                 495     


Glu Gly Leu Asn Pro Tyr Gly Leu Val Ala Pro Arg Phe Gln Arg Lys 
            500                 505                 510         


Phe Lys Ala Lys Gln Leu Thr Pro Arg Ile Leu Glu Ala His Gln Asn 
        515                 520                 525             


Val Ala Gln Leu Ser Leu Thr Glu Ala Gln Leu Arg Phe Ile Gln Ala 
    530                 535                 540                 


Trp Gln Ser Leu Pro Asp Phe Gly Ile Ser Tyr Val Met Val Arg Phe 
545                 550                 555                 560 


Lys Gly Ser Arg Lys Asp Glu Ile Leu Gly Ile Ala Asn Asn Arg Leu 
                565                 570                 575     


Ile Arg Ile Asp Leu Ala Val Gly Asp Val Val Lys Thr Trp Arg Phe 
            580                 585                 590         


Ser Asn Met Arg Gln Trp Asn Val Asn Trp Asp Ile Arg Gln Val Ala 
        595                 600                 605             


Ile Glu Phe Asp Glu His Ile Asn Val Ala Phe Ser Cys Val Ser Ala 
    610                 615                 620                 


Ser Cys Arg Ile Val His Glu Tyr Ile Gly Gly Tyr Ile Phe Leu Ser 
625                 630                 635                 640 


Thr Arg Glu Arg Ala Arg Gly Glu Glu Leu Asp Glu Asp Leu Phe Leu 
                645                 650                 655     


Gln Leu Thr Gly Gly His Glu Ala Phe 
            660                 665 


<210> 180
<211> 1263
<212> DNA
<213> Homo sapiens

<400> 180
ttcctttctc tctcagctct ccgtctctct ttctctctca gcctctttct ttctccctgt       60

ctcccccact gtcagcacct cttctgtgtg gtgagtggac cgcttacccc actaggtgaa      120

gatgtcagcc caggagagct gcctcagcct catcaagtac ttcctcttcg ttttcaacct      180

cttcttcttc gtcctcggca gcctgatctt ctgcttcggc atctggatcc tcattgacaa      240

gaccagcttc gtgtcctttg tgggcttggc cttcgtgcct ctgcagatct ggtccaaagt      300

cctggccatc tcaggaatct tcaccatggg catcgccctc ctgggttgtg tgggggccct      360

caaggagctc cgctgcctcc tgggcctgta ttttgggatg ctgctgctcc tgtttgccac      420

acagatcacc ctgggaatcc tcatctccac tcagcgggcc cagctggagc gaagcttgcg      480

ggacgtcgta gagaaaacca tccaaaagta cggcaccaac cccgaggaga ccgcggccga      540

ggagagctgg gactatgtgc agttccagct gcgctgctgc ggctggcact acccgcagga      600

ctggttccaa gtcctcatcc tgagaggtaa cgggtcggag gcgcaccgcg tgccctgctc      660

ctgctacaac ttgtcggcga ccaacgactc cacaatccta gataaggtga tcttgcccca      720

gctcagcagg cttggacacc tggcgcggtc cagacacagt gcagacatct gcgctgtccc      780

tgcagagagc cacatctacc gcgagggctg cgcgcagggc ctccagaagt ggctgcacaa      840

caaccttatt tccatagtgg gcatttgcct gggcgtcggc ctactcgagc tcgggttcat      900

gacgctctcg atattcctgt gcagaaacct ggaccacgtc tacaaccggc tcgctcgata      960

ccgttaggcc ccgccctccc caaagtcccg ccccgccccc gtcacgtgcg ctgggcactt     1020

ccctgctgcc tgtaaatatt tgtttaatcc ccagttcgcc tggagccctc cgccttcaca     1080

ttcccctggg gacccacgtg gctgcgtgcc cctgctgctg tcacctctcc cacgggacct     1140

ggggctttcg tccacagctt cctgtcccca tctgtcggcc taccaccacc cacaagatta     1200

tttttcaccc aaacctcaaa taaatcccct gcgtttttgg taaaaaaaaa aaaaaaaaaa     1260

aaa                                                                   1263


<210> 181
<211> 281
<212> PRT
<213> Homo sapiens

<400> 181
Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg 
        275                 280     


<210> 182
<211> 1229
<212> DNA
<213> Homo sapiens

<400> 182
ttcctttctc tctcagctct ccgtctctct ttctctctca gcctctttct ttctccctgt       60

ctcccccact gtcagcacct cttctgtgtg gtgagtggac cgcttacccc actaggtgaa      120

gatgtcagcc caggagagct gcctcagcct catcaagtcc tcggcagcct gatcttctgc      180

ttcggcatct ggatcctcat tgacaagacc agcttcgtgt cctttgtggg cttggccttc      240

gtgcctctgc agatctggtc caaagtcctg gccatctcag gaatcttcac catgggcatc      300

gccctcctgg gttgtgtggg ggccctcaag gagctccgct gcctcctggg cctgtatttt      360

gggatgctgc tgctcctgtt tgccacacag atcaccctgg gaatcctcat ctccactcag      420

cgggcccagc tggagcgaag cttgcgggac gtcgtagaga aaaccatcca aaagtacggc      480

accaaccccg aggagaccgc ggccgaggag agctgggact atgtgcagtt ccagctgcgc      540

tgctgcggct ggcactaccc gcaggactgg ttccaagtcc tcatcctgag aggtaacggg      600

tcggaggcgc accgcgtgcc ctgctcctgc tacaacttgt cggcgaccaa cgactccaca      660

atcctagata aggtgatctt gccccagctc agcaggcttg gacacctggc gcggtccaga      720

cacagtgcag acatctgcgc tgtccctgca gagagccaca tctaccgcga gggctgcgcg      780

cagggcctcc agaagtggct gcacaacaac cttatttcca tagtgggcat ttgcctgggc      840

gtcggcctac tcgagctcgg gttcatgacg ctctcgatat tcctgtgcag aaacctggac      900

cacgtctaca accggctcgc tcgataccgt taggccccgc cctccccaaa gtcccgcccc      960

gcccccgtca cgtgcgctgg gcacttccct gctgcctgta aatatttgtt taatccccag     1020

ttcgcctgga gccctccgcc ttcacattcc cctggggacc cacgtggctg cgtgcccctg     1080

ctgctgtcac ctctcccacg ggacctgggg ctttcgtcca cagcttcctg tccccatctg     1140

tcggcctacc accacccaca agattatttt tcacccaaac ctcaaataaa tcccctgcgt     1200

ttttggtaaa aaaaaaaaaa aaaaaaaaa                                       1229


<210> 183
<211> 213
<212> PRT
<213> Homo sapiens

<400> 183
Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu Lys Glu Leu Arg 
1               5                   10                  15      


Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu Leu Phe Ala Thr 
            20                  25                  30          


Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg Ala Gln Leu Glu 
        35                  40                  45              


Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln Lys Tyr Gly Thr 
    50                  55                  60                  


Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp Tyr Val Gln Phe 
65                  70                  75                  80  


Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp Trp Phe Gln Val 
                85                  90                  95      


Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg Val Pro Cys Ser 
            100                 105                 110         


Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile Leu Asp Lys Val 
        115                 120                 125             


Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala Arg Ser Arg His 
    130                 135                 140                 


Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His Ile Tyr Arg Glu 
145                 150                 155                 160 


Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn Asn Leu Ile Ser 
                165                 170                 175     


Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu Leu Gly Phe Met 
            180                 185                 190         


Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His Val Tyr Asn Arg 
        195                 200                 205             


Leu Ala Arg Tyr Arg 
    210             


<210> 184
<211> 1277
<212> DNA
<213> Mus musculus

<400> 184
tgtctgtgag gttgaactct gcagaaacaa ccttgaagtc ccaggaccca cgtgagtgga       60

agtccatcag aagcccctgt gcgccctgcc tgagctatgg acacctgcga ggaacccatt      120

gtgtccctgg cacccacata ttccaaggac cctcaggcga agatgtccgc ccaagagagt      180

tgcctcagcc tcatcaagta cttcctcttc gttttcaacc tcttcttctt tgtactaggc      240

ggcctgattt tctgcttcgg cacctggatc ctcattgaca agaccagctt cgtgtccttt      300

gtgggtttgt ccttcgtgcc actgcagact tggtccaagg tcctggctgt ctcaggtgtc      360

ctcaccatgg ccctggctct cctgggctgt gtgggggctc taaaggagct gcgctgtctc      420

ctgggcctgt attttggaat gctgctgctc ctgtttgcca cacagattac cctgggcatc      480

ctcatttcca ctcagcgggt ccggctggag cgaagggtgc aggaattggt gttgaggacg      540

atccagagct accgcacgaa tccggatgag acagcagccg aggagagttg ggactatgca      600

cagttccagc tgcgctgctg cggctggcaa tctccgcggg actggaacaa ggcccagatg      660

ctgaaagcga acgagtctga ggagcccttt gtgccctgct cctgctacaa ctccacggcg      720

accaatgact ccaccgtctt tgataagctc tttttctccc agctaagccg gttggggccg      780

cgggcgaagc tgaggcagac tgctgacata tgtgcactcc ctgcaaaagc tcacatctac      840

cgtgagggct gcgcgcagag cctccagaag tggctgcaca acaatatcat ctccatagtg      900

ggaatctgtc tgggagtcgg tcttcttgag ctcggcttca tgacgctctc aatattcctg      960

tgtagaaatc tggatcacgt ctatgaccgg ctggcccggt accgctaggc cccagcccac     1020

ccatcggcac ccacgcacct ccatgcagtc aggaaatgtt tccttcctgg ttggtcacag     1080

gcttggagcc catgcctcag gcctcatccc ctggggaccc agctgtctgc cctatcgaca     1140

gccttcactt tccccacatg gccagggact tttgtgccca gcttccttcc cttcctggct     1200

ccctcctccc cacaccatct gtctgccacc tcccacatga cacctcaaat aaatcccctt     1260

tgggtttttg gcttttt                                                    1277


<210> 185
<211> 303
<212> PRT
<213> Mus musculus

<400> 185
Met Asp Thr Cys Glu Glu Pro Ile Val Ser Leu Ala Pro Thr Tyr Ser 
1               5                   10                  15      


Lys Asp Pro Gln Ala Lys Met Ser Ala Gln Glu Ser Cys Leu Ser Leu 
            20                  25                  30          


Ile Lys Tyr Phe Leu Phe Val Phe Asn Leu Phe Phe Phe Val Leu Gly 
        35                  40                  45              


Gly Leu Ile Phe Cys Phe Gly Thr Trp Ile Leu Ile Asp Lys Thr Ser 
    50                  55                  60                  


Phe Val Ser Phe Val Gly Leu Ser Phe Val Pro Leu Gln Thr Trp Ser 
65                  70                  75                  80  


Lys Val Leu Ala Val Ser Gly Val Leu Thr Met Ala Leu Ala Leu Leu 
                85                  90                  95      


Gly Cys Val Gly Ala Leu Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr 
            100                 105                 110         


Phe Gly Met Leu Leu Leu Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile 
        115                 120                 125             


Leu Ile Ser Thr Gln Arg Val Arg Leu Glu Arg Arg Val Gln Glu Leu 
    130                 135                 140                 


Val Leu Arg Thr Ile Gln Ser Tyr Arg Thr Asn Pro Asp Glu Thr Ala 
145                 150                 155                 160 


Ala Glu Glu Ser Trp Asp Tyr Ala Gln Phe Gln Leu Arg Cys Cys Gly 
                165                 170                 175     


Trp Gln Ser Pro Arg Asp Trp Asn Lys Ala Gln Met Leu Lys Ala Asn 
            180                 185                 190         


Glu Ser Glu Glu Pro Phe Val Pro Cys Ser Cys Tyr Asn Ser Thr Ala 
        195                 200                 205             


Thr Asn Asp Ser Thr Val Phe Asp Lys Leu Phe Phe Ser Gln Leu Ser 
    210                 215                 220                 


Arg Leu Gly Pro Arg Ala Lys Leu Arg Gln Thr Ala Asp Ile Cys Ala 
225                 230                 235                 240 


Leu Pro Ala Lys Ala His Ile Tyr Arg Glu Gly Cys Ala Gln Ser Leu 
                245                 250                 255     


Gln Lys Trp Leu His Asn Asn Ile Ile Ser Ile Val Gly Ile Cys Leu 
            260                 265                 270         


Gly Val Gly Leu Leu Glu Leu Gly Phe Met Thr Leu Ser Ile Phe Leu 
        275                 280                 285             


Cys Arg Asn Leu Asp His Val Tyr Asp Arg Leu Ala Arg Tyr Arg 
    290                 295                 300             


<210> 186
<211> 1202
<212> DNA
<213> Mus musculus

<400> 186
tgtctgtgag gttgaactct gcagaaacaa ccttgaagtc ccaggaccca cgtgagtgga       60

agtccatcag aagcccctgt gcgccctgcc tgagctatgg acacctgcga ggaacccatt      120

gtgtccctgg cacccacata ttccaaggac cctcaggtac taggcggcct gattttctgc      180

ttcggcacct ggatcctcat tgacaagacc agcttcgtgt cctttgtggg tttgtccttc      240

gtgccactgc agacttggtc caaggtcctg gctgtctcag gtgtcctcac catggccctg      300

gctctcctgg gctgtgtggg ggctctaaag gagctgcgct gtctcctggg cctgtatttt      360

ggaatgctgc tgctcctgtt tgccacacag attaccctgg gcatcctcat ttccactcag      420

cgggtccggc tggagcgaag ggtgcaggaa ttggtgttga ggacgatcca gagctaccgc      480

acgaatccgg atgagacagc agccgaggag agttgggact atgcacagtt ccagctgcgc      540

tgctgcggct ggcaatctcc gcgggactgg aacaaggccc agatgctgaa agcgaacgag      600

tctgaggagc cctttgtgcc ctgctcctgc tacaactcca cggcgaccaa tgactccacc      660

gtctttgata agctcttttt ctcccagcta agccggttgg ggccgcgggc gaagctgagg      720

cagactgctg acatatgtgc actccctgca aaagctcaca tctaccgtga gggctgcgcg      780

cagagcctcc agaagtggct gcacaacaat atcatctcca tagtgggaat ctgtctggga      840

gtcggtcttc ttgagctcgg cttcatgacg ctctcaatat tcctgtgtag aaatctggat      900

cacgtctatg accggctggc ccggtaccgc taggccccag cccacccatc ggcacccacg      960

cacctccatg cagtcaggaa atgtttcctt cctggttggt cacaggcttg gagcccatgc     1020

ctcaggcctc atcccctggg gacccagctg tctgccctat cgacagcctt cactttcccc     1080

acatggccag ggacttttgt gcccagcttc cttcccttcc tggctccctc ctccccacac     1140

catctgtctg ccacctccca catgacacct caaataaatc ccctttgggt ttttggcttt     1200

tt                                                                    1202


<210> 187
<211> 278
<212> PRT
<213> Mus musculus

<400> 187
Met Asp Thr Cys Glu Glu Pro Ile Val Ser Leu Ala Pro Thr Tyr Ser 
1               5                   10                  15      


Lys Asp Pro Gln Val Leu Gly Gly Leu Ile Phe Cys Phe Gly Thr Trp 
            20                  25                  30          


Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly Leu Ser Phe 
        35                  40                  45              


Val Pro Leu Gln Thr Trp Ser Lys Val Leu Ala Val Ser Gly Val Leu 
    50                  55                  60                  


Thr Met Ala Leu Ala Leu Leu Gly Cys Val Gly Ala Leu Lys Glu Leu 
65                  70                  75                  80  


Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu Leu Phe Ala 
                85                  90                  95      


Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg Val Arg Leu 
            100                 105                 110         


Glu Arg Arg Val Gln Glu Leu Val Leu Arg Thr Ile Gln Ser Tyr Arg 
        115                 120                 125             


Thr Asn Pro Asp Glu Thr Ala Ala Glu Glu Ser Trp Asp Tyr Ala Gln 
    130                 135                 140                 


Phe Gln Leu Arg Cys Cys Gly Trp Gln Ser Pro Arg Asp Trp Asn Lys 
145                 150                 155                 160 


Ala Gln Met Leu Lys Ala Asn Glu Ser Glu Glu Pro Phe Val Pro Cys 
                165                 170                 175     


Ser Cys Tyr Asn Ser Thr Ala Thr Asn Asp Ser Thr Val Phe Asp Lys 
            180                 185                 190         


Leu Phe Phe Ser Gln Leu Ser Arg Leu Gly Pro Arg Ala Lys Leu Arg 
        195                 200                 205             


Gln Thr Ala Asp Ile Cys Ala Leu Pro Ala Lys Ala His Ile Tyr Arg 
    210                 215                 220                 


Glu Gly Cys Ala Gln Ser Leu Gln Lys Trp Leu His Asn Asn Ile Ile 
225                 230                 235                 240 


Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu Leu Gly Phe 
                245                 250                 255     


Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His Val Tyr Asp 
            260                 265                 270         


Arg Leu Ala Arg Tyr Arg 
        275             


<210> 188
<211> 1226
<212> DNA
<213> Mus musculus

<400> 188
tttgtgcctc tcagtctctg tctttctttg cccactattc cccttccccc ctgcggccaa       60

cacctcttct gtctgggttt ctcgagtggg tcattcccca tctaggcgaa gatgtccgcc      120

caagagagtt gcctcagcct catcaagtac ttcctcttcg ttttcaacct cttcttcttt      180

gtactaggcg gcctgatttt ctgcttcggc acctggatcc tcattgacaa gaccagcttc      240

gtgtcctttg tgggtttgtc cttcgtgcca ctgcagactt ggtccaaggt cctggctgtc      300

tcaggtgtcc tcaccatggc cctggctctc ctgggctgtg tgggggctct aaaggagctg      360

cgctgtctcc tgggcctgta ttttggaatg ctgctgctcc tgtttgccac acagattacc      420

ctgggcatcc tcatttccac tcagcgggtc cggctggagc gaagggtgca ggaattggtg      480

ttgaggacga tccagagcta ccgcacgaat ccggatgaga cagcagccga ggagagttgg      540

gactatgcac agttccagct gcgctgctgc ggctggcaat ctccgcggga ctggaacaag      600

gcccagatgc tgaaagcgaa cgagtctgag gagccctttg tgccctgctc ctgctacaac      660

tccacggcga ccaatgactc caccgtcttt gataagctct ttttctccca gctaagccgg      720

ttggggccgc gggcgaagct gaggcagact gctgacatat gtgcactccc tgcaaaagct      780

cacatctacc gtgagggctg cgcgcagagc ctccagaagt ggctgcacaa caatatcatc      840

tccatagtgg gaatctgtct gggagtcggt cttcttgagc tcggcttcat gacgctctca      900

atattcctgt gtagaaatct ggatcacgtc tatgaccggc tggcccggta ccgctaggcc      960

ccagcccacc catcggcacc cacgcacctc catgcagtca ggaaatgttt ccttcctggt     1020

tggtcacagg cttggagccc atgcctcagg cctcatcccc tggggaccca gctgtctgcc     1080

ctatcgacag ccttcacttt ccccacatgg ccagggactt ttgtgcccag cttccttccc     1140

ttcctggctc cctcctcccc acaccatctg tctgccacct cccacatgac acctcaaata     1200

aatccccttt gggtttttgg cttttt                                          1226


<210> 189
<211> 281
<212> PRT
<213> Mus musculus

<400> 189
Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Gly Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Thr Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ser Phe Val Pro Leu Gln Thr Trp Ser Lys Val Leu Ala Val Ser 
    50                  55                  60                  


Gly Val Leu Thr Met Ala Leu Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Val Arg Leu Glu Arg Arg Val Gln Glu Leu Val Leu Arg Thr Ile Gln 
        115                 120                 125             


Ser Tyr Arg Thr Asn Pro Asp Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Ala Gln Phe Gln Leu Arg Cys Cys Gly Trp Gln Ser Pro Arg Asp 
145                 150                 155                 160 


Trp Asn Lys Ala Gln Met Leu Lys Ala Asn Glu Ser Glu Glu Pro Phe 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Ser Thr Ala Thr Asn Asp Ser Thr Val 
            180                 185                 190         


Phe Asp Lys Leu Phe Phe Ser Gln Leu Ser Arg Leu Gly Pro Arg Ala 
        195                 200                 205             


Lys Leu Arg Gln Thr Ala Asp Ile Cys Ala Leu Pro Ala Lys Ala His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Ser Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Ile Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asp Arg Leu Ala Arg Tyr Arg 
        275                 280     


<210> 190
<211> 1927
<212> DNA
<213> Homo sapiens

<400> 190
attctgtggc ttgatgtggc tttgtcagtt actgcctccc cacctcccgg gacttcccac       60

tgcctcttta gcacaaatcg gacttgaaca aaaacaactc tttttccatg ggaccaatta      120

taaaaagaat ggctttgcac tgagcagctc agtctactgg tctcatcagt gaaaggcttg      180

tgaaaatttc tggaaagagc attggctggc ttgttcatct ctctgtttgg tcagttgctg      240

tgtttctgcc ggatcagatg agcagattgg ttagtgaagg tcagtgtgag aagaagattg      300

tttctgagct tgagaagctt ctggaggatt gaagagtatt tgaagtctgt gtcaaacatc      360

catatcataa gtggaatttt ggagatattc aaagaatgct gtcagaaggg tatctcagtg      420

gacttgagta ctggaatgac atccactgga gttgtgcctc ttataatgag caggtggctg      480

gggaaaagga agaggagaca aattctgttg ctaccctttc ctattcctct gtggatgaaa      540

cacaagtcag aagtctctac gtgagctgca aatcatctgg caagtttatc tcttcagtgc      600

attcaagaga gagccaacat agcagaagtc agagagtcac agtgctgcag acaaacccca      660

atcctgtgtt tgaaagccca aacttggctg cagttgaaat atgtagagat gccagcagag      720

agacctactt ggttccatct tcttgcaaaa gtatttgcaa gaattataat gacttacaga      780

ttgcaggggg ccaggtgatg gccattaatt cagtgacaac agattttccc tctgagagca      840

gttttgaata tggccctttg ctgaagtcat ctgagattcc tttacccatg gaggattcca      900

tttctactca gcccagtgac tttccccaaa aacctatcca gcggtactca tcctattgga      960

gaataacaag catcaaagag aaaagcagct tgcaaatgca gaatcctatt tctaatgcag     1020

ttctgaatga gtacctggag cagaaggttg tggagttata taaacagtac attatggaca     1080

ccgtgtttca tgacagttct cctacccaga ttctggcgtc tgaactcatc atgacaagtg     1140

tagaccaaat cagtcttcaa gtgtctagag agaagaatct ggagacctca aaagccagag     1200

atatagtctt tagccgccta ttgcaattga tgtcaactga aattactgaa attagcactc     1260

ctagtctcca tatttctcag tatagcaatg taaatccata gagaggatgc ttccattact     1320

gtctcgcatt tacttaaaca tgaagcaaca ctttatccat ttattctgag aatgtgcagg     1380

aggggttagt gaaggggaat taagggctag agaagtaaag atcagctgga agtcatgtgt     1440

gaatcatgga gaaatctcat aatattacac ttgatgaagg aatatggtaa gaggagccat     1500

aaggaatgat ttcaaagaga ggtgtgtaca gcaaggaagc aaaaataaaa atgatcaaaa     1560

aagaaacggt taattcattt gaagaaacat aggaattaaa aaagaagaca gtcaaatgag     1620

atgaaacaaa aaggccaaaa ggtggccggg tgtagtggct cacgcctgta atcccagcat     1680

ttcggaggct gatgtgggtg gattacctga cgtcaggaat tcgagaccgg cctggccaat     1740

atggtgaaac cccatctcta ctaaaaatac aaaaaattag ctggacatgg tggtgggtac     1800

ctgtaatccc agctactagg gaggctgagg caggagaatc tcttgaacct gagaggcaga     1860

ggttgcagtg agccgaggtc gctccattgc actccagcct gggcaacaag agtgagactc     1920

ccgtctc                                                               1927


<210> 191
<211> 301
<212> PRT
<213> Homo sapiens

<400> 191
Met Leu Ser Glu Gly Tyr Leu Ser Gly Leu Glu Tyr Trp Asn Asp Ile 
1               5                   10                  15      


His Trp Ser Cys Ala Ser Tyr Asn Glu Gln Val Ala Gly Glu Lys Glu 
            20                  25                  30          


Glu Glu Thr Asn Ser Val Ala Thr Leu Ser Tyr Ser Ser Val Asp Glu 
        35                  40                  45              


Thr Gln Val Arg Ser Leu Tyr Val Ser Cys Lys Ser Ser Gly Lys Phe 
    50                  55                  60                  


Ile Ser Ser Val His Ser Arg Glu Ser Gln His Ser Arg Ser Gln Arg 
65                  70                  75                  80  


Val Thr Val Leu Gln Thr Asn Pro Asn Pro Val Phe Glu Ser Pro Asn 
                85                  90                  95      


Leu Ala Ala Val Glu Ile Cys Arg Asp Ala Ser Arg Glu Thr Tyr Leu 
            100                 105                 110         


Val Pro Ser Ser Cys Lys Ser Ile Cys Lys Asn Tyr Asn Asp Leu Gln 
        115                 120                 125             


Ile Ala Gly Gly Gln Val Met Ala Ile Asn Ser Val Thr Thr Asp Phe 
    130                 135                 140                 


Pro Ser Glu Ser Ser Phe Glu Tyr Gly Pro Leu Leu Lys Ser Ser Glu 
145                 150                 155                 160 


Ile Pro Leu Pro Met Glu Asp Ser Ile Ser Thr Gln Pro Ser Asp Phe 
                165                 170                 175     


Pro Gln Lys Pro Ile Gln Arg Tyr Ser Ser Tyr Trp Arg Ile Thr Ser 
            180                 185                 190         


Ile Lys Glu Lys Ser Ser Leu Gln Met Gln Asn Pro Ile Ser Asn Ala 
        195                 200                 205             


Val Leu Asn Glu Tyr Leu Glu Gln Lys Val Val Glu Leu Tyr Lys Gln 
    210                 215                 220                 


Tyr Ile Met Asp Thr Val Phe His Asp Ser Ser Pro Thr Gln Ile Leu 
225                 230                 235                 240 


Ala Ser Glu Leu Ile Met Thr Ser Val Asp Gln Ile Ser Leu Gln Val 
                245                 250                 255     


Ser Arg Glu Lys Asn Leu Glu Thr Ser Lys Ala Arg Asp Ile Val Phe 
            260                 265                 270         


Ser Arg Leu Leu Gln Leu Met Ser Thr Glu Ile Thr Glu Ile Ser Thr 
        275                 280                 285             


Pro Ser Leu His Ile Ser Gln Tyr Ser Asn Val Asn Pro 
    290                 295                 300     


<210> 192
<211> 3835
<212> DNA
<213> Mus musculus

<400> 192
ctcttgttcc ataggatcag tgatactaag aagggggcag atcttagtag cctcttcagt       60

gagagacttg agagcttttt gaaaagagcc ctgtctggct agttcttctc tattagatca      120

gtcattgtgt tgctgcagga tccaaggagc agactccggt gaagaatgct atcagaagga      180

tatctcagtg gacttaccta ctggaatgac attcattgga attgtgcatc ttataatgaa      240

ccggtggctg gggaccaagg caaagagaca agttctgttg ctgctctttc atattcctct      300

gtggatgaaa cacaagttca aagtctttat gtgagctgca aatcctctgg gaagtttatt      360

tcatcagtgc atgcaagggc gagtcagcac agcagaagcc agagcagaac agtgctgcag      420

gcaaacagca accctgtatt tgaaagtcca actttagctg cagttggtat atgcagagat      480

gtgatcaggg agacctactt ggttccacct tcttgtaaaa gtatttgcaa aaattacaac      540

gacttacata ttgcaggggg acaggtgatg gccattaact cagtaatggc aaatttcccc      600

tctgagagca gctttgaaga tggtcctttg ctaaagtcat ctgagatttc tttgtccatg      660

gaggattcca cttccactca gctcactgaa cttcccctca aacctatcca gcggtactca      720

tcctactgga ggataaccag catcaaagag aaaagcagcc tgcaaatgca gaagcctatt      780

tcaaatgcag tgctcaatga gtacctggag cagaaggtgg tggaattgta taagcaatat      840

attatggaca ctgtgtttca tgacagttct cctacccaga ttctggcatc agaattcatc      900

atgacgaatg tagatcaaat tagtcttcaa gtgtctaaag agaagaacct ggacacttca      960

aaagtcaagg acatagttat tagccacctg ttgcagttgg tatcatctga gatcagcacc     1020

cctagtcttc atatttctca gtatagcaat ataactccat agagaaggct cctgtcaatt     1080

ccccttattc ctatgaatcc caaggcacta ttgtattaat ttgatcagag gatgtgatgg     1140

agggaattct ggaagggaat taacaactag taaaggacac tttgagaaat cacatatgga     1200

aaggaacagg aagaggaacc aaaagaatgg tttcaaggac aagtttatac agaatcagag     1260

caaaattaaa aatgatcaca gagagaagga aggtactgtg attcaatttt aggagttctg     1320

aaactggaag ttaagccaaa tcaggaacaa aaggaaacac tatggcaaac tagaaagtcg     1380

atggatttga gaattgggaa ttaaacacct gtttcctatt tagatacatt tatctaggtt     1440

gtttcttctg gaaagaaatg gactacaaga tggttgttaa attcaggtgg actgacattt     1500

ttccaagtat aagcttgtat ttcttttcct ctgtgctata tcagtaagtc atgtagatat     1560

actctttata aatattaaat gaatgacaaa caaatctcag ttgtttaaac attttttttt     1620

tttgcaacaa ggctctatta gctcaggctg gttttacaat ccttacatag ccgatgatct     1680

tgaattcctt attctcttgc ttctatccca caagtgctgg tattataggt atgtatcatc     1740

aaatctggat gtgtttttat ttgaaatgaa aaggttcagc cacaagacta tgacttaaat     1800

ctcctaattc tatttagtga tagagatagc agtgtttcaa cggaaaacct cctattgtga     1860

acattgaagc attttatttc actgagtgtg attttcatgg tgctatgagg ttcaaaagga     1920

ttatgaatac tttgcccccc atttcccttt ttcatgtgtt cttctgacct ggagccagaa     1980

aagggtcttc tgattgttct atacaagacc aaggactcca taatttcaat ttctgtatat     2040

ttgtttacta aaacagtagc tttacatgtg tattactgtc ttgatctttt attcagctca     2100

ggacttagaa aactatgagc ctttggtcaa atctaacttt atgatagctt tggactctcg     2160

tgagctaagg ataggttttc cttttctctt ttcttttttc cctttctttt ccttttttcc     2220

ttttcttttt cttgagggag ggcctcttta ttgtatagct ccagctgtct ggaactccct     2280

atgtagacca ggctggtgtc taacacacag agatttgtct gcctgtgctt cccacatgct     2340

aggaggatta agggcatgtg ccattatatc acacttggca tgttttatta tttttaattt     2400

taatatattt taaaagccca aaagcttaag ttaaaaatac tttagagcat atgaaaatta     2460

tatgaaattt aaaattgaaa ttcagtgtat ataaactaga ctttatttgt ttatttattt     2520

atttatttat ttattggcag tgctggtgat ggaattcaag gccttattca tgacaggcaa     2580

gttctataac atattccatg ctgcctacta aattttattt gtttgtttat attttatata     2640

gtttgtagtt gcttttacat aagaatggtc gaacagacat gacggagaac atatgacaca     2700

acaaagctta atatttcttt ttaccatctg gctgtttaca gtgatgtttg ccaactctgt     2760

tcaatgacag tgtcttgccc aaacttgatt taggttttcc aggaagcaga ctttcgaaag     2820

gacattgggg agcattttta tccttatggg gaataggttc cctctgtgat ggaatgaggg     2880

aagcaaatcc agatgttacc agaaagagtt agggtgaatc ttcaaaatag ttccaaattg     2940

aaacaagtga gtaggcgtct gttctcaagc gtctaagtgc aaggtgcata ccttgactga     3000

tggccacagg tctatggagt ggagtggagt ggagtggagt ggagtggagt gaatagctgc     3060

agcctctggt caggagcctg gtgtctagga gcatggaaaa aggcctacca ttccagtgca     3120

ggctaaggtc acctgctggg ttaccggggt tttaaaccta gctcaaccag aaaccaggct     3180

gcctctcata gtcccacaac taatgaccca aagtccatta catccacacc cagccaaatt     3240

ttctactatc attcttgaaa ttatgtgagg ttctataact gtacataaat aaataaataa     3300

aagcactgca gaaatctgaa atggctttag taaaattttc tgccacaatg ggactacaac     3360

agtttagatt cagaaattca gtcttccttt ttttcttttt aaaaaatttt attgggttca     3420

ttgattctac caagactagt ctgcacaggg gagagtgtgt cactctatga aagactaata     3480

tttcctaaaa ttgtgaggca gagaaaattc tttccttaag ttgcttctgt gtggtgtttg     3540

ttatggcaat aagaaattaa tcgagccatc ttagttccca gatccctctg agactatctg     3600

cacaggtgag agtatggact acagaagcta acagcttccg ggacagaccc tgtttcaggt     3660

tctcatcttc tgccaggagg cagatctgat tgccagatat ctgtgaacct ttcctgcaag     3720

aggagagctt gcatgcagtg agtgctctga ccactgaaac tcagaagaga gctagtcccc     3780

caggtctgct gatagagcgt aacagaatca cctgaggaac aagctctaac cagag          3835


<210> 193
<211> 298
<212> PRT
<213> Mus musculus

<400> 193
Met Leu Ser Glu Gly Tyr Leu Ser Gly Leu Thr Tyr Trp Asn Asp Ile 
1               5                   10                  15      


His Trp Asn Cys Ala Ser Tyr Asn Glu Pro Val Ala Gly Asp Gln Gly 
            20                  25                  30          


Lys Glu Thr Ser Ser Val Ala Ala Leu Ser Tyr Ser Ser Val Asp Glu 
        35                  40                  45              


Thr Gln Val Gln Ser Leu Tyr Val Ser Cys Lys Ser Ser Gly Lys Phe 
    50                  55                  60                  


Ile Ser Ser Val His Ala Arg Ala Ser Gln His Ser Arg Ser Gln Ser 
65                  70                  75                  80  


Arg Thr Val Leu Gln Ala Asn Ser Asn Pro Val Phe Glu Ser Pro Thr 
                85                  90                  95      


Leu Ala Ala Val Gly Ile Cys Arg Asp Val Ile Arg Glu Thr Tyr Leu 
            100                 105                 110         


Val Pro Pro Ser Cys Lys Ser Ile Cys Lys Asn Tyr Asn Asp Leu His 
        115                 120                 125             


Ile Ala Gly Gly Gln Val Met Ala Ile Asn Ser Val Met Ala Asn Phe 
    130                 135                 140                 


Pro Ser Glu Ser Ser Phe Glu Asp Gly Pro Leu Leu Lys Ser Ser Glu 
145                 150                 155                 160 


Ile Ser Leu Ser Met Glu Asp Ser Thr Ser Thr Gln Leu Thr Glu Leu 
                165                 170                 175     


Pro Leu Lys Pro Ile Gln Arg Tyr Ser Ser Tyr Trp Arg Ile Thr Ser 
            180                 185                 190         


Ile Lys Glu Lys Ser Ser Leu Gln Met Gln Lys Pro Ile Ser Asn Ala 
        195                 200                 205             


Val Leu Asn Glu Tyr Leu Glu Gln Lys Val Val Glu Leu Tyr Lys Gln 
    210                 215                 220                 


Tyr Ile Met Asp Thr Val Phe His Asp Ser Ser Pro Thr Gln Ile Leu 
225                 230                 235                 240 


Ala Ser Glu Phe Ile Met Thr Asn Val Asp Gln Ile Ser Leu Gln Val 
                245                 250                 255     


Ser Lys Glu Lys Asn Leu Asp Thr Ser Lys Val Lys Asp Ile Val Ile 
            260                 265                 270         


Ser His Leu Leu Gln Leu Val Ser Ser Glu Ile Ser Thr Pro Ser Leu 
        275                 280                 285             


His Ile Ser Gln Tyr Ser Asn Ile Thr Pro 
    290                 295             


<210> 194
<211> 1155
<212> DNA
<213> Homo sapiens

<400> 194
gtttggtaag ttccgttttt agccccggcc tttttctagc caggctctca actgtctcct       60

gcgttgctgg gaagttctgg aaggaagcat gtgctccaga ggttgggatt cgtgtctggc      120

tctggaattg ctactgctgc ctctgtcact cctggtgacc agcattcaag gtcacttggt      180

acatatgacc gtggtctccg gcagcaacgt gactctgaac atctctgaga gcctgcctga      240

gaactacaaa caactaacct ggttttatac tttcgaccag aagattgtag aatgggattc      300

cagaaaatct aagtactttg aatccaaatt taaaggcagg gtcagacttg atcctcagag      360

tggcgcactg tacatctcta aggtccagaa agaggacaac agcacctaca tcatgagggt      420

gttgaaaaag actgggaatg agcaagaatg gaagatcaag ctgcaagtgc ttgaccctgt      480

acccaagcct gtcatcaaaa ttgagaagat agaagacatg gatgacaact gttatctgaa      540

actgtcatgt gtgatacctg gcgagtctgt aaactacacc tggtatgggg acaaaaggcc      600

cttcccaaag gagctccaga acagtgtgct tgaaaccacc cttatgccac ataattactc      660

caggtgttat acttgccaag tcagcaattc tgtgagcagc aagaatggca cggtctgcct      720

cagtccaccc tgtaccctgg cccggtcctt tggagtagaa tggattgcaa gttggctagt      780

ggtcacggtg cccaccattc ttggcctgtt acttacctga gatgagctct tttaactcaa      840

gcgaaacttc aaggccagaa gatcttgcct gttggtgatc atgctcctca ccaggacaga      900

gactgtatag gctgaccaga agcatgctgc tgaattatca acgaggattt tcaagttaac      960

ttttaaatac tggttattat ttaattttat atccctttgt tgttttctag tacacagaga     1020

tatagagata cacatgcttt tttcccaccc aaaattgtga caacattatg tgaatgtttt     1080

attatttttt aaaataaaca tttgatataa ttgtcaatta actgaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaa                                                      1155


<210> 195
<211> 243
<212> PRT
<213> Homo sapiens

<400> 195
Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Thr Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Thr 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Thr Leu Ala Arg Ser Phe Gly Val Glu 
    210                 215                 220                 


Trp Ile Ala Ser Trp Leu Val Val Thr Val Pro Thr Ile Leu Gly Leu 
225                 230                 235                 240 


Leu Leu Thr 
            


<210> 196
<211> 1537
<212> DNA
<213> Homo sapiens

<400> 196
gtttggtaag ttccgttttt agccccggcc tttttctagc caggctctca actgtctcct       60

gcgttgctgg gaagttctgg aaggaagcat gtgctccaga ggttgggatt cgtgtctggc      120

tctggaattg ctactgctgc ctctgtcact cctggtgacc agcattcaag gtcacttggt      180

acatatgacc gtggtctccg gcagcaacgt gactctgaac atctctgaga gcctgcctga      240

gaactacaaa caactaacct ggttttatac tttcgaccag aagattgtag aatgggattc      300

cagaaaatct aagtactttg aatccaaatt taaaggcagg gtcagacttg atcctcagag      360

tggcgcactg tacatctcta aggtccagaa agaggacaac agcacctaca tcatgagggt      420

gttgaaaaag actgggaatg agcaagaatg gaagatcaag ctgcaagtgc ttgaccctgt      480

acccaagcct gtcatcaaaa ttgagaagat agaagacatg gatgacaact gttatctgaa      540

actgtcatgt gtgatacctg gcgagtctgt aaactacacc tggtatgggg acaaaaggcc      600

cttcccaaag gagctccaga acagtgtgct tgaaaccacc cttatgccac ataattactc      660

caggtgttat acttgccaag tcagcaattc tgtgagcagc aagaatggca cggtctgcct      720

cagtccaccc tgtaccctgg gtaagaagga tccctgggag ctgagggggg cacagggtaa      780

ctggagttgt tttgaacaaa gaaaggctgg gggtcctatt cagcctcctt gcacagtgtg      840

gtggtgaatc cctaaggtgt ctgggagagc tgggagacgt gggttctgcc accagctcta      900

ccaccacctc ccagccagct tacctcaact tcgtgggggc tcagtgttct cacctgcaaa      960

ggacgtttgg gagagatctc tgatactcct cttccctctc ccgctctaac aaagcatagt     1020

cctaacatct gaggccaggg tcatcataga gtagactgaa acatcagggt gagcagggag     1080

aaggaagggc aagtgggcga gcagctgtct agaggggctt cattagacag ccgaagtcag     1140

ccaaggaaag agggaccgag gtcattagac cgccaaagtc agccagggaa agagggactg     1200

aggagacggg cctgagagag gccgtcgagg aggcgtgaga gcctgagcct caggcgaagc     1260

ttctcctccc cagcctgatg ttcctagatg aacttaggaa gccagattcc cctgtctcct     1320

gggaggatcc actcatgagt gtcacacctg gctctagatc aggcctacac tggtgctagc     1380

atgggacagc taaggccatg ggttttagag tcagtcatac ctggggtcac ttctaggact     1440

gtcacttact agctaaacaa gttacttagc ttccccaagt catgttcttc ctaaataaag     1500

gacaaaataa cagttcctat aaaaaaaaaa aaaaaaa                              1537


<210> 197
<211> 252
<212> PRT
<213> Homo sapiens

<400> 197
Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Thr Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Thr 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Thr Leu Gly Lys Lys Asp Pro Trp Glu 
    210                 215                 220                 


Leu Arg Gly Ala Gln Gly Asn Trp Ser Cys Phe Glu Gln Arg Lys Ala 
225                 230                 235                 240 


Gly Gly Pro Ile Gln Pro Pro Cys Thr Val Trp Trp 
                245                 250         


<210> 198
<211> 1205
<212> DNA
<213> Mus musculus

<400> 198
atacgacttc cggttttggg ttttgcttcc tgattgaagg gcaggcgccc tgacttctct       60

tacagttgtc tccagtgttc tggggaagct tctctaagta ttatgtgctt cataaaacag      120

ggatggtgtc tggtcctgga actgctactg ctgcccttgg gaactggatt tcaaggtcat      180

tcaataccag atataaatgc caccaccggc agcaatgtaa ccctgaaaat ccataaggac      240

ccacttggac catataaacg tatcacctgg cttcatacta aaaatcagaa gattttagag      300

tacaactata atagtacaaa gacaatcttc gagtctgaat ttaaaggcag ggtttatctt      360

gaagaaaaca atggtgcact tcatatctct aatgtccgga aagaggacaa aggtacctac      420

tacatgagag tgctgcgtga aactgagaac gagttgaaga taaccctgga agtatttgat      480

cctgtgccca agccttccat agaaatcaat aagactgaag cgtcgactga ttcctgtcac      540

ctgaggctat cgtgtgaggt aaaggaccag catgttgact atacttggta tgagagctcg      600

ggacctttcc ccaaaaagag tccaggatat gtgctcgatc tcatcgtcac accacagaac      660

aagtctacat tttacacctg ccaagtcagc aatcctgtaa gcagcaagaa cgacacagtg      720

tacttcactc taccttgtga tctagccaga tcttctggag tatgttggac tgcaacttgg      780

ctagtggtca caacactcat cattcacagg atcctgttaa cctgacaaga actcttctca      840

cccaagaagg caacttggaa gcacagagtc ttgccttcat ccctagcagt gttcctagcc      900

agcgaagcaa ctctggctct attggacaaa ggaaaatgtg ttactgaacg tctgcgagag      960

tttgcatgca tgctctatga aacaagcaca ggaccttgta cagtgctcca ccactgacct     1020

gtgtgcccag tcctttacaa agatttcaaa tcaacctttt aaaaactgtg cataatatct     1080

aattttatat accctagttg tttcccaaca tatattaaag ataaatgcat tctttttacc     1140

aaaatgtgac tatattattt tcatgttttc atatctcttt ttaaaataaa ttcttttaaa     1200

aaact                                                                 1205


<210> 199
<211> 240
<212> PRT
<213> Mus musculus

<400> 199
Met Cys Phe Ile Lys Gln Gly Trp Cys Leu Val Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Gly Thr Gly Phe Gln Gly His Ser Ile Pro Asp Ile Asn 
            20                  25                  30          


Ala Thr Thr Gly Ser Asn Val Thr Leu Lys Ile His Lys Asp Pro Leu 
        35                  40                  45              


Gly Pro Tyr Lys Arg Ile Thr Trp Leu His Thr Lys Asn Gln Lys Ile 
    50                  55                  60                  


Leu Glu Tyr Asn Tyr Asn Ser Thr Lys Thr Ile Phe Glu Ser Glu Phe 
65                  70                  75                  80  


Lys Gly Arg Val Tyr Leu Glu Glu Asn Asn Gly Ala Leu His Ile Ser 
                85                  90                  95      


Asn Val Arg Lys Glu Asp Lys Gly Thr Tyr Tyr Met Arg Val Leu Arg 
            100                 105                 110         


Glu Thr Glu Asn Glu Leu Lys Ile Thr Leu Glu Val Phe Asp Pro Val 
        115                 120                 125             


Pro Lys Pro Ser Ile Glu Ile Asn Lys Thr Glu Ala Ser Thr Asp Ser 
    130                 135                 140                 


Cys His Leu Arg Leu Ser Cys Glu Val Lys Asp Gln His Val Asp Tyr 
145                 150                 155                 160 


Thr Trp Tyr Glu Ser Ser Gly Pro Phe Pro Lys Lys Ser Pro Gly Tyr 
                165                 170                 175     


Val Leu Asp Leu Ile Val Thr Pro Gln Asn Lys Ser Thr Phe Tyr Thr 
            180                 185                 190         


Cys Gln Val Ser Asn Pro Val Ser Ser Lys Asn Asp Thr Val Tyr Phe 
        195                 200                 205             


Thr Leu Pro Cys Asp Leu Ala Arg Ser Ser Gly Val Cys Trp Thr Ala 
    210                 215                 220                 


Thr Trp Leu Val Val Thr Thr Leu Ile Ile His Arg Ile Leu Leu Thr 
225                 230                 235                 240 


<210> 200
<211> 938
<212> DNA
<213> Mus musculus

<400> 200
atacgacttc cggttttggg ttttgcttcc tgattgaagg gcaggcgccc tgacttctct       60

tacagttgtc tccagtgttc tggggaagct tctctaagta ttatgtgctt cataaaacag      120

ggatggtgtc tggtcctgga actgctactg ctgcccttgg gaactggatt tcaaggtcat      180

tcaataccag atataaatgc caccaccggc agcaatgtaa ccctgaaaat ccataaggac      240

ccacttggac catataaacg tatcacctgg cttcatacta aaaatcagaa gattttagag      300

tacaactata atagtacaaa gacaatcttc gagtctgaat ttaaaggcag ggtttatctt      360

gaagaaaaca atggtgcact tcatatctct aatgtccgga aagaggacaa aggtacctac      420

tacatgagag tgctgcgtga aactgagaac gagttgaaga taaccctgga agtatttgcc      480

agatcttctg gagtatgttg gactgcaact tggctagtgg tcacaacact catcattcac      540

aggatcctgt taacctgaca agaactcttc tcacccaaga aggcaacttg gaagcacaga      600

gtcttgcctt catccctagc agtgttccta gccagcgaag caactctggc tctattggac      660

aaaggaaaat gtgttactga acgtctgcga gagtttgcat gcatgctcta tgaaacaagc      720

acaggacctt gtacagtgct ccaccactga cctgtgtgcc cagtccttta caaagatttc      780

aaatcaacct tttaaaaact gtgcataata tctaatttta tataccctag ttgtttccca      840

acatatatta aagataaatg cattcttttt accaaaatgt gactatatta ttttcatgtt      900

ttcatatctc tttttaaaat aaattctttt aaaaaact                              938


<210> 201
<211> 151
<212> PRT
<213> Mus musculus

<400> 201
Met Cys Phe Ile Lys Gln Gly Trp Cys Leu Val Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Gly Thr Gly Phe Gln Gly His Ser Ile Pro Asp Ile Asn 
            20                  25                  30          


Ala Thr Thr Gly Ser Asn Val Thr Leu Lys Ile His Lys Asp Pro Leu 
        35                  40                  45              


Gly Pro Tyr Lys Arg Ile Thr Trp Leu His Thr Lys Asn Gln Lys Ile 
    50                  55                  60                  


Leu Glu Tyr Asn Tyr Asn Ser Thr Lys Thr Ile Phe Glu Ser Glu Phe 
65                  70                  75                  80  


Lys Gly Arg Val Tyr Leu Glu Glu Asn Asn Gly Ala Leu His Ile Ser 
                85                  90                  95      


Asn Val Arg Lys Glu Asp Lys Gly Thr Tyr Tyr Met Arg Val Leu Arg 
            100                 105                 110         


Glu Thr Glu Asn Glu Leu Lys Ile Thr Leu Glu Val Phe Ala Arg Ser 
        115                 120                 125             


Ser Gly Val Cys Trp Thr Ala Thr Trp Leu Val Val Thr Thr Leu Ile 
    130                 135                 140                 


Ile His Arg Ile Leu Leu Thr 
145                 150     


<210> 202
<211> 8296
<212> DNA
<213> Homo sapiens

<400> 202
ggaggaagaa aactcaagtg aaactgactc tgctagaaca gtgccgtgct tttccacaga       60

aggttagacc ctgaaagaga tggctcagca ccacctatgg atcttgctcc tttgcctgca      120

aacctggccg gaagcagctg gaaaagactc agaaatcttc acagtgaatg ggattctggg      180

agagtcagtc actttccctg taaatatcca agaaccacgg caagttaaaa tcattgcttg      240

gacttctaaa acatctgttg cttatgtaac accaggagac tcagaaacag cacccgtagt      300

tactgtgacc cacagaaatt attatgaacg gatacatgcc ttaggtccga actacaatct      360

ggtcattagc gatctgagga tggaagacgc aggagactac aaagcagaca taaatacaca      420

ggctgatccc tacaccacca ccaagcgcta caacctgcaa atctatcgtc ggcttgggaa      480

accaaaaatt acacagagtt taatggcatc tgtgaacagc acctgtaatg tcacactgac      540

atgctctgta gagaaagaag aaaagaatgt gacatacaat tggagtcccc tgggagaaga      600

gggtaatgtc cttcaaatct tccagactcc tgaggaccaa gagctgactt acacgtgtac      660

agcccagaac cctgtcagca acaattctga ctccatctct gcccggcagc tctgtgcaga      720

catcgcaatg ggcttccgta ctcaccacac cgggttgctg agcgtgctgg ctatgttctt      780

tctgcttgtt ctcattctgt cttcagtgtt tttgttccgt ttgttcaaga gaagacaagg      840

taggattttc ccagaaggtt cctgcttgaa caccttcact aagaaccctt atgctgcctc      900

aaagaaaacc atatacacat atatcatggc ttcaaggaac acccagccag cagagtccag      960

aatctatgat gaaatcctgc agtccaaggt gcttccctcc aaggaagagc cagtgaacac     1020

agtttattcc gaagtgcagt ttgctgataa gatggggaaa gccagcacac aggacagtaa     1080

acctcctggg acttcaagct atgaaattgt gatctaggct gctgggctga attctccctc     1140

tggaaactga gttacaacca ccaatactgg caggttccct ggatccagat cttctctgcc     1200

caactcttac tgggagattg caaactgcca catctcagcc tgtaagcaaa gcaggaaacc     1260

ttctgctggg catagcttgt gcctaaatgg acaaatggat gcataccctt cctgaaatga     1320

ctcccttctg aatgaatgac aaagcaggtt acctagtata gttttcccaa acttcttccc     1380

atcatagcac atgtagaaaa taatattttt atggcacact gggataaaca agcaagattg     1440

ctcacttctg gaagctgcat atgactagag gcctcttgtg actggaggta acaaccctgc     1500

ccagtaactg tgggagaagg ggatcaatat tttgcacacc tgtaataggc catggcacac     1560

cagccaagat gctctgctca cagtcagtat gtgtgaagat ccctggtgcg tggccttcac     1620

cacgcatctt gagcaaatta ggaaaatgta cccttcgctt gaggcagatg cagcccttcc     1680

cccgagtgca tggcttggag agcagaatgt gggctgcata taagcacact catccctttg     1740

tctgggaatc tttgtgcagg gcataacagg cttagtaagt ccaaacacag atgacagtgc     1800

tgtgtgggtc tctgtcagag ttgtggctct cagccatgta gacacactct ccaaatggag     1860

tgttggaaaa tgttctttct gcagggtcta gagactgctg ggacactttt cttggagtgc     1920

tacttcagaa gccttatagg attttctttc tggccaagat ttccttctgt atcactccaa     1980

gcagcctcag cagaagaagc agccatgccc agtattccca ctctccaaaa ggaactgacc     2040

agcttatatt tctcacactt ctggggaact gggtataatc caaccatcaa aatagaagac     2100

cttgcaagaa gcagagtcat tctccagaag gaacttggga gatgatggtg cagatgatga     2160

aactgggttc atcccagttc caaagactca gagaactaga gtttaagctg aggcagagtg     2220

ccgccaccct ggcatgcccc acaaacagat caccagccag cttacacagg cattaactct     2280

cctcaatgag gaagaatcat tcacaactga gcaagacatt catatgatca tttaaggaag     2340

tgtttccctt atgtgttagc aagtataatc ggctaactcc taaatcccaa tgaatagtcc     2400

taggctggac agcaatgggc tgcaattagg cagataaaga catcagtccc agtaaatgaa     2460

tccatagact catctagcac caactaccat tagcactatg ttaggagctg caaggcccca     2520

aagtagaaga tgtgcataat gtctgctctt gtgtagctca ggagacaatt ccagcacaga     2580

cactacagtt aacgctgaac tgcagctgca agtaatagca tgaacagtca gaaaaatacc     2640

ttatgagggg gcagggctga agctgggcct tgaaggatgg atgaaatttg gatagagaat     2700

gaggaagaca gagggcctcc aagtgagaga agcatgaaaa atgagcaggg gcctggatca     2760

gtggggtgta ttcagagcac ctctccagat gcaccatgca tgctcacagt cccttgccta     2820

tgtgtggcag agtgtcccag ccagatgtgt gccctcaccc catgtccatt tacatgtcct     2880

tcaatgccca cctcaaaagg tacctcttct gtaaagcttt ccctggtatc aggaatcaaa     2940

attaatcagg gatcttttca cactgctgtt ttttcctctt tggtccttct atcactaaaa     3000

ctcatctcat tcagccttac agcataacta attatttgtt ttcctcacta cattgtacat     3060

gtgggaatta cagataaacg gaagccggct ggggtggtgg ctcacgcctg taatcccaac     3120

actttgggag gccaaggcag gcggatcacc tgaggtcagg agttcgagat tagtctggcc     3180

aacatggtga aaccccatct ctactaaaaa tacgaaatta gccaggtgtg gtggcacaca     3240

tctgtagtcc cagctactct ggaggctgag acaggagaat cgcttgaacc caggaagtgg     3300

aggttgcagt gagctgagat cacaccactg cactccagcc tgggagagac agagtgagac     3360

tccatctcga aaaaaaaaaa aagatagaag ccaataagca tggtgcaatc aaattctggc     3420

aagcattaaa tatcaggatg cagctgggca cggtggctca cgcctgtaat cccagcactt     3480

tgggaggcca aggtgggcgg atcacttgag gtcaggaatt tgagaggatc ctggccagca     3540

tggcaaaacc ccatctgtac ttaaaataca aaaaaattag ctgggcgtgg tggtgcacac     3600

ctgtaatccc agctacttgg gaggctgagg tgggagaatt gcttgaacct gggaggtgga     3660

ggttgcagtg agctgagatc ctgccactgc actccaggct gggcaacaga gtgagaccat     3720

gtctcaaaaa ataaaaataa aataaaataa tatcaggatg catacatcag aggctgttcc     3780

tagtgtaaag gcactttgga gggagaagac tttcagagtt aggcagacca actaagaggt     3840

cagctgaagc acctaaccag ttgtaaggag gtgaaagaca gcaccccaag aagagacgtg     3900

caggaaggag gaaagaggct tggtcataaa ggatggagga attccaaagt gacactgaac     3960

aggctgcgtt tatcctaaaa taaaaccact cctcactctg tggatgcgtt gaagactcat     4020

tcccaaacat ctttattctc taacttgccc tcttcctctt cctaatatgc tcactcaagt     4080

aaaattacta gtgtcctaat gcccctatgc atattgtcaa aaataaaaat cagaagcagg     4140

ttagatctgt taggtcttcc agaagagcaa acctgggatg aagccagagc ccaggaattc     4200

tgaaggtagc ctttggactc aggacaccct actcttgtct ctcctctcag tttctctgct     4260

atgaatctcc tgattcatga acacgttatc tgttcaccct tctctctagg tcttagttct     4320

tagattttcc ttctgtaaaa tgcatgtgat cttattttcc cctccacaac tttccagatg     4380

aactagactg tgaccaagag gtctataaaa tcaaagcatc atggaacagg atcttgtatc     4440

agaccaaagt gtgccagttt ttaaaaatgt gcatcaaaat ggaagtctca gagacagagc     4500

cctctggtgg aaagttctag taggttagga cagtcctgcc tgcagacacc ttgggcttta     4560

ctgagggact caactgagaa aatgaggaat gttgcagctc atgattctta gaagaagaaa     4620

gtgaagcttg tttaaaatat gatttaaaaa atctgtagaa cactgtaaac tacacaggct     4680

atgagggaat agcctggttg ggccagcttg gaaatcgggc acaggcagga aggggcctgt     4740

ctggtttggg ccgtgtccac agagagcact tcttaggtcc tgcctggaga gaaggaatgg     4800

ctgggctata ttttcttcca gactcattat ttttcttctg tttgactttt ctctgaattt     4860

cccttgattt gtataaattt tctcaataat tagtgacagt gtctactgat tgtaaaatga     4920

agcttgaagg ccaggcgcag tggctcatgc ctgtaatcct agaattttgg gaggccaagg     4980

tgggtggatc acaaggagtt cgagaccagc ctggccaagg ttgtgaaacc gcgtctctac     5040

taaaaataca aaaaaattag ccgggcatgg tggcacgtgc ctgtagtccc agctactcag     5100

gaagctgagg caacagaatc acttgaacct gggaggtgga ggttgcagtg agccgagatc     5160

acgccactgc actccagcct gggcgagaga gtgagactcc gtctcaaaaa aaaaaaaaaa     5220

aaaaaaagtt tgaagaacaa agacaataag aggaaatata atgagtggtc ataaatgtgg     5280

gctctgacag tagagtgcct gggtctgcat cctggtttct tagtcatgtg accttaggca     5340

agttacttta acctcgctgt acctcaggtt gtccatctgt aaaatgggga taataatagt     5400

gcctaccttt taaggttgat gtggggatta aatgaggtgt tgctcataca ggaatgtgcc     5460

tgtgcatggc aaagttcggg aaatttttta taagctgttc taggcctgaa atcttcagaa     5520

gatgctaatc taaattcatg aaataagctt cttacaacag aaatgctgct agtattatgc     5580

aaaattaatg ttgtatatca aacttttaac tctcatccct ccttattcag atatattttg     5640

ttataagcaa tgtttgttcc cctcgttatt ataccacagt ctacttacct gatgctatat     5700

ctgcctcccc agttagactg agagaacagg ggatatacct aaataataat aataataata     5760

ataataataa ataataatgg agagctcctt gaagataggg agcctgtaag aatcattgag     5820

ggcttatttt gtataccaac tgctaaacta gatgcttcat acattgttgt caatactcat     5880

gacagccttg taaagtagaa attaattctt ccagttaaca ctaaggctga catatgaata     5940

ccttggcaaa tctggaaagc tgggaagaca gtatttgaat tcaagacttc ttgtcaccaa     6000

gggccatgca cttgtactct gccatgtggc ccttttttac ctcctgtgga ttctccctac     6060

ctggtacttg gccttaggtg tacacacacc tggcactttg cttgacacat aataggtgga     6120

ccacaaatat ctactaaatg aatatttgca tatagtaata ttttaaggta ctaaaagcag     6180

ctcaaagtaa atatattaat atattaattc cattgctatc tggataacca ctcaactttc     6240

ctgctgaaaa tgcccattta attaaagaag gttggataga gctctctata tgcattttgg     6300

acaggcaggg gtttcaggtc ataaacattc tgatgagtta atataaaata agagaaactg     6360

taaatttcca ctactaaaaa tcacaaaaat aacagaaaca aaagaagaga taagaatttg     6420

gggaattgtg ctgaacaatt tagtggttaa aaaaaacaac tgtgcatgtt tagacttaaa     6480

taagccccca tccaagtgtg aggggtccag taatttttca aaacatatga aagtgttaat     6540

acatttcgac aaaggaccat taaaaaagtc ctgaattctg acttgaggga ggaaagtaat     6600

gactaataca ttctctagag acttgcagac tttgggaatt cataaaggaa tggatgataa     6660

ttattaactg ttgctggctg attgcccaga cagttctcaa cagccctgta caagtctctg     6720

ggtttgggat ggatcaattc tgagactgga aaatggccaa atctttgcaa atgagaaata     6780

tttttcttat aagttcttat tgtaggcaaa taattacata gattattcat cagagaattt     6840

ttaaatgctc ataatctcaa ctctttcatt tacaacttgt atttccaata gtttatgggt     6900

catctctgca tagatgtcag aagtcacctc aagtttagcg tgtccaaaat ctaactcaca     6960

ggtctgtttc tgacctccca acttgctttc cttgtgtttt tcctatgcta atgatccacc     7020

ataatcaaaa taattaacat ttatccagtg cctactatgt actattccct gtcctgtttt     7080

acatttactc atttaaagtc cataagaaac attaaatctc atctgccttc tgaagaagat     7140

acaaccatgc tctcttttac aaagtaggaa actgggtcac agaaaggtga agtctttaag     7200

gctgaatcac agtagctcat cctagtaaat agaaaagcca ggattcaact ccaggggctg     7260

ggtgcagaac tgctattctt cactgcttca ccaatcagca gctacccaag gcagaaaact     7320

ttttcatcct tggctccttc attctccctg tcaccccaga tcccctctac atctagtcag     7380

agaataggtc ctgtcaattc caacttctct atatggctcc tctcaggcat gtgcccttaa     7440

ttggcctaat tctctaatac accttccctc tacatgctca ctccctcaga tcattgcttt     7500

atcacgtgtt acctgggttg ctattacata aagagcaatc tttctaaaat gaggatctta     7560

tcacttcact tccacactaa aatgtttttc ctggggaacc acactcctta gcaatctgac     7620

ccatcagacc ttccaggctg tctcctgcct gctccctaag gctccagcca cacagaatta     7680

tcatgggccc acacacccac caaatcctcc catgcctttg cccatgttgt ctgggatgcc     7740

cttctctccc ttctgtctac atcaagcatc agactgaata tccctcttgt gcggccttct     7800

aaaacctccc gtccaaagcg aaatatattg ccctctattt atacttttac agcatttggc     7860

acacaagtac agagtagtag ctttttatca cattctctga taattatata gatatggtat     7920

ttcttagctc tctctccaac tggctaataa gttgcttttt gtctgagtgc ctaattttgt     7980

gttttgtgtc tgagtgcctc agttcctcaa aaaaaggttt tttgattagt tcattattca     8040

tttgaacatg gaaattatgc tcactagtgg caaatgccac taaccgtatt ccagaagcta     8100

ggtgtcatgt ttgcaataag atatattatc ccttctacaa gtcacctttt atttcaggca     8160

tttgtaaatg cccattaata aagtatggtt cataaatttt accttgtaag tgcctaagaa     8220

atgagactac aagctccatt tcagcaggac acaataaata ttattttata atgcatctaa     8280

aaaaaaaaaa aaaaaa                                                     8296


<210> 203
<211> 345
<212> PRT
<213> Homo sapiens

<400> 203
Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Gly Arg Ile 
                245                 250                 255     


Phe Pro Glu Gly Ser Cys Leu Asn Thr Phe Thr Lys Asn Pro Tyr Ala 
            260                 265                 270         


Ala Ser Lys Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr 
        275                 280                 285             


Gln Pro Ala Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val 
    290                 295                 300                 


Leu Pro Ser Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln 
305                 310                 315                 320 


Phe Ala Asp Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro 
                325                 330                 335     


Gly Thr Ser Ser Tyr Glu Ile Val Ile 
            340                 345 


<210> 204
<211> 8245
<212> DNA
<213> Homo sapiens

<400> 204
ggaggaagaa aactcaagtg aaactgactc tgctagaaca gtgccgtgct tttccacaga       60

aggttagacc ctgaaagaga tggctcagca ccacctatgg atcttgctcc tttgcctgca      120

aacctggccg gaagcagctg gaaaagactc agaaatcttc acagtgaatg ggattctggg      180

agagtcagtc actttccctg taaatatcca agaaccacgg caagttaaaa tcattgcttg      240

gacttctaaa acatctgttg cttatgtaac accaggagac tcagaaacag cacccgtagt      300

tactgtgacc cacagaaatt attatgaacg gatacatgcc ttaggtccga actacaatct      360

ggtcattagc gatctgagga tggaagacgc aggagactac aaagcagaca taaatacaca      420

ggctgatccc tacaccacca ccaagcgcta caacctgcaa atctatcgtc ggcttgggaa      480

accaaaaatt acacagagtt taatggcatc tgtgaacagc acctgtaatg tcacactgac      540

atgctctgta gagaaagaag aaaagaatgt gacatacaat tggagtcccc tgggagaaga      600

gggtaatgtc cttcaaatct tccagactcc tgaggaccaa gagctgactt acacgtgtac      660

agcccagaac cctgtcagca acaattctga ctccatctct gcccggcagc tctgtgcaga      720

catcgcaatg ggcttccgta ctcaccacac cgggttgctg agcgtgctgg ctatgttctt      780

tctgcttgtt ctcattctgt cttcagtgtt tttgttccgt ttgttcaaga gaagacaaga      840

tgctgcctca aagaaaacca tatacacata tatcatggct tcaaggaaca cccagccagc      900

agagtccaga atctatgatg aaatcctgca gtccaaggtg cttccctcca aggaagagcc      960

agtgaacaca gtttattccg aagtgcagtt tgctgataag atggggaaag ccagcacaca     1020

ggacagtaaa cctcctggga cttcaagcta tgaaattgtg atctaggctg ctgggctgaa     1080

ttctccctct ggaaactgag ttacaaccac caatactggc aggttccctg gatccagatc     1140

ttctctgccc aactcttact gggagattgc aaactgccac atctcagcct gtaagcaaag     1200

caggaaacct tctgctgggc atagcttgtg cctaaatgga caaatggatg catacccttc     1260

ctgaaatgac tcccttctga atgaatgaca aagcaggtta cctagtatag ttttcccaaa     1320

cttcttccca tcatagcaca tgtagaaaat aatattttta tggcacactg ggataaacaa     1380

gcaagattgc tcacttctgg aagctgcata tgactagagg cctcttgtga ctggaggtaa     1440

caaccctgcc cagtaactgt gggagaaggg gatcaatatt ttgcacacct gtaataggcc     1500

atggcacacc agccaagatg ctctgctcac agtcagtatg tgtgaagatc cctggtgcgt     1560

ggccttcacc acgcatcttg agcaaattag gaaaatgtac ccttcgcttg aggcagatgc     1620

agcccttccc ccgagtgcat ggcttggaga gcagaatgtg ggctgcatat aagcacactc     1680

atccctttgt ctgggaatct ttgtgcaggg cataacaggc ttagtaagtc caaacacaga     1740

tgacagtgct gtgtgggtct ctgtcagagt tgtggctctc agccatgtag acacactctc     1800

caaatggagt gttggaaaat gttctttctg cagggtctag agactgctgg gacacttttc     1860

ttggagtgct acttcagaag ccttatagga ttttctttct ggccaagatt tccttctgta     1920

tcactccaag cagcctcagc agaagaagca gccatgccca gtattcccac tctccaaaag     1980

gaactgacca gcttatattt ctcacacttc tggggaactg ggtataatcc aaccatcaaa     2040

atagaagacc ttgcaagaag cagagtcatt ctccagaagg aacttgggag atgatggtgc     2100

agatgatgaa actgggttca tcccagttcc aaagactcag agaactagag tttaagctga     2160

ggcagagtgc cgccaccctg gcatgcccca caaacagatc accagccagc ttacacaggc     2220

attaactctc ctcaatgagg aagaatcatt cacaactgag caagacattc atatgatcat     2280

ttaaggaagt gtttccctta tgtgttagca agtataatcg gctaactcct aaatcccaat     2340

gaatagtcct aggctggaca gcaatgggct gcaattaggc agataaagac atcagtccca     2400

gtaaatgaat ccatagactc atctagcacc aactaccatt agcactatgt taggagctgc     2460

aaggccccaa agtagaagat gtgcataatg tctgctcttg tgtagctcag gagacaattc     2520

cagcacagac actacagtta acgctgaact gcagctgcaa gtaatagcat gaacagtcag     2580

aaaaatacct tatgaggggg cagggctgaa gctgggcctt gaaggatgga tgaaatttgg     2640

atagagaatg aggaagacag agggcctcca agtgagagaa gcatgaaaaa tgagcagggg     2700

cctggatcag tggggtgtat tcagagcacc tctccagatg caccatgcat gctcacagtc     2760

ccttgcctat gtgtggcaga gtgtcccagc cagatgtgtg ccctcacccc atgtccattt     2820

acatgtcctt caatgcccac ctcaaaaggt acctcttctg taaagctttc cctggtatca     2880

ggaatcaaaa ttaatcaggg atcttttcac actgctgttt tttcctcttt ggtccttcta     2940

tcactaaaac tcatctcatt cagccttaca gcataactaa ttatttgttt tcctcactac     3000

attgtacatg tgggaattac agataaacgg aagccggctg gggtggtggc tcacgcctgt     3060

aatcccaaca ctttgggagg ccaaggcagg cggatcacct gaggtcagga gttcgagatt     3120

agtctggcca acatggtgaa accccatctc tactaaaaat acgaaattag ccaggtgtgg     3180

tggcacacat ctgtagtccc agctactctg gaggctgaga caggagaatc gcttgaaccc     3240

aggaagtgga ggttgcagtg agctgagatc acaccactgc actccagcct gggagagaca     3300

gagtgagact ccatctcgaa aaaaaaaaaa agatagaagc caataagcat ggtgcaatca     3360

aattctggca agcattaaat atcaggatgc agctgggcac ggtggctcac gcctgtaatc     3420

ccagcacttt gggaggccaa ggtgggcgga tcacttgagg tcaggaattt gagaggatcc     3480

tggccagcat ggcaaaaccc catctgtact taaaatacaa aaaaattagc tgggcgtggt     3540

ggtgcacacc tgtaatccca gctacttggg aggctgaggt gggagaattg cttgaacctg     3600

ggaggtggag gttgcagtga gctgagatcc tgccactgca ctccaggctg ggcaacagag     3660

tgagaccatg tctcaaaaaa taaaaataaa ataaaataat atcaggatgc atacatcaga     3720

ggctgttcct agtgtaaagg cactttggag ggagaagact ttcagagtta ggcagaccaa     3780

ctaagaggtc agctgaagca cctaaccagt tgtaaggagg tgaaagacag caccccaaga     3840

agagacgtgc aggaaggagg aaagaggctt ggtcataaag gatggaggaa ttccaaagtg     3900

acactgaaca ggctgcgttt atcctaaaat aaaaccactc ctcactctgt ggatgcgttg     3960

aagactcatt cccaaacatc tttattctct aacttgccct cttcctcttc ctaatatgct     4020

cactcaagta aaattactag tgtcctaatg cccctatgca tattgtcaaa aataaaaatc     4080

agaagcaggt tagatctgtt aggtcttcca gaagagcaaa cctgggatga agccagagcc     4140

caggaattct gaaggtagcc tttggactca ggacacccta ctcttgtctc tcctctcagt     4200

ttctctgcta tgaatctcct gattcatgaa cacgttatct gttcaccctt ctctctaggt     4260

cttagttctt agattttcct tctgtaaaat gcatgtgatc ttattttccc ctccacaact     4320

ttccagatga actagactgt gaccaagagg tctataaaat caaagcatca tggaacagga     4380

tcttgtatca gaccaaagtg tgccagtttt taaaaatgtg catcaaaatg gaagtctcag     4440

agacagagcc ctctggtgga aagttctagt aggttaggac agtcctgcct gcagacacct     4500

tgggctttac tgagggactc aactgagaaa atgaggaatg ttgcagctca tgattcttag     4560

aagaagaaag tgaagcttgt ttaaaatatg atttaaaaaa tctgtagaac actgtaaact     4620

acacaggcta tgagggaata gcctggttgg gccagcttgg aaatcgggca caggcaggaa     4680

ggggcctgtc tggtttgggc cgtgtccaca gagagcactt cttaggtcct gcctggagag     4740

aaggaatggc tgggctatat tttcttccag actcattatt tttcttctgt ttgacttttc     4800

tctgaatttc ccttgatttg tataaatttt ctcaataatt agtgacagtg tctactgatt     4860

gtaaaatgaa gcttgaaggc caggcgcagt ggctcatgcc tgtaatccta gaattttggg     4920

aggccaaggt gggtggatca caaggagttc gagaccagcc tggccaaggt tgtgaaaccg     4980

cgtctctact aaaaatacaa aaaaattagc cgggcatggt ggcacgtgcc tgtagtccca     5040

gctactcagg aagctgaggc aacagaatca cttgaacctg ggaggtggag gttgcagtga     5100

gccgagatca cgccactgca ctccagcctg ggcgagagag tgagactccg tctcaaaaaa     5160

aaaaaaaaaa aaaaaagttt gaagaacaaa gacaataaga ggaaatataa tgagtggtca     5220

taaatgtggg ctctgacagt agagtgcctg ggtctgcatc ctggtttctt agtcatgtga     5280

ccttaggcaa gttactttaa cctcgctgta cctcaggttg tccatctgta aaatggggat     5340

aataatagtg cctacctttt aaggttgatg tggggattaa atgaggtgtt gctcatacag     5400

gaatgtgcct gtgcatggca aagttcggga aattttttat aagctgttct aggcctgaaa     5460

tcttcagaag atgctaatct aaattcatga aataagcttc ttacaacaga aatgctgcta     5520

gtattatgca aaattaatgt tgtatatcaa acttttaact ctcatccctc cttattcaga     5580

tatattttgt tataagcaat gtttgttccc ctcgttatta taccacagtc tacttacctg     5640

atgctatatc tgcctcccca gttagactga gagaacaggg gatataccta aataataata     5700

ataataataa taataataaa taataatgga gagctccttg aagataggga gcctgtaaga     5760

atcattgagg gcttattttg tataccaact gctaaactag atgcttcata cattgttgtc     5820

aatactcatg acagccttgt aaagtagaaa ttaattcttc cagttaacac taaggctgac     5880

atatgaatac cttggcaaat ctggaaagct gggaagacag tatttgaatt caagacttct     5940

tgtcaccaag ggccatgcac ttgtactctg ccatgtggcc cttttttacc tcctgtggat     6000

tctccctacc tggtacttgg ccttaggtgt acacacacct ggcactttgc ttgacacata     6060

ataggtggac cacaaatatc tactaaatga atatttgcat atagtaatat tttaaggtac     6120

taaaagcagc tcaaagtaaa tatattaata tattaattcc attgctatct ggataaccac     6180

tcaactttcc tgctgaaaat gcccatttaa ttaaagaagg ttggatagag ctctctatat     6240

gcattttgga caggcagggg tttcaggtca taaacattct gatgagttaa tataaaataa     6300

gagaaactgt aaatttccac tactaaaaat cacaaaaata acagaaacaa aagaagagat     6360

aagaatttgg ggaattgtgc tgaacaattt agtggttaaa aaaaacaact gtgcatgttt     6420

agacttaaat aagcccccat ccaagtgtga ggggtccagt aatttttcaa aacatatgaa     6480

agtgttaata catttcgaca aaggaccatt aaaaaagtcc tgaattctga cttgagggag     6540

gaaagtaatg actaatacat tctctagaga cttgcagact ttgggaattc ataaaggaat     6600

ggatgataat tattaactgt tgctggctga ttgcccagac agttctcaac agccctgtac     6660

aagtctctgg gtttgggatg gatcaattct gagactggaa aatggccaaa tctttgcaaa     6720

tgagaaatat ttttcttata agttcttatt gtaggcaaat aattacatag attattcatc     6780

agagaatttt taaatgctca taatctcaac tctttcattt acaacttgta tttccaatag     6840

tttatgggtc atctctgcat agatgtcaga agtcacctca agtttagcgt gtccaaaatc     6900

taactcacag gtctgtttct gacctcccaa cttgctttcc ttgtgttttt cctatgctaa     6960

tgatccacca taatcaaaat aattaacatt tatccagtgc ctactatgta ctattccctg     7020

tcctgtttta catttactca tttaaagtcc ataagaaaca ttaaatctca tctgccttct     7080

gaagaagata caaccatgct ctcttttaca aagtaggaaa ctgggtcaca gaaaggtgaa     7140

gtctttaagg ctgaatcaca gtagctcatc ctagtaaata gaaaagccag gattcaactc     7200

caggggctgg gtgcagaact gctattcttc actgcttcac caatcagcag ctacccaagg     7260

cagaaaactt tttcatcctt ggctccttca ttctccctgt caccccagat cccctctaca     7320

tctagtcaga gaataggtcc tgtcaattcc aacttctcta tatggctcct ctcaggcatg     7380

tgcccttaat tggcctaatt ctctaataca ccttccctct acatgctcac tccctcagat     7440

cattgcttta tcacgtgtta cctgggttgc tattacataa agagcaatct ttctaaaatg     7500

aggatcttat cacttcactt ccacactaaa atgtttttcc tggggaacca cactccttag     7560

caatctgacc catcagacct tccaggctgt ctcctgcctg ctccctaagg ctccagccac     7620

acagaattat catgggccca cacacccacc aaatcctccc atgcctttgc ccatgttgtc     7680

tgggatgccc ttctctccct tctgtctaca tcaagcatca gactgaatat ccctcttgtg     7740

cggccttcta aaacctcccg tccaaagcga aatatattgc cctctattta tacttttaca     7800

gcatttggca cacaagtaca gagtagtagc tttttatcac attctctgat aattatatag     7860

atatggtatt tcttagctct ctctccaact ggctaataag ttgctttttg tctgagtgcc     7920

taattttgtg ttttgtgtct gagtgcctca gttcctcaaa aaaaggtttt ttgattagtt     7980

cattattcat ttgaacatgg aaattatgct cactagtggc aaatgccact aaccgtattc     8040

cagaagctag gtgtcatgtt tgcaataaga tatattatcc cttctacaag tcacctttta     8100

tttcaggcat ttgtaaatgc ccattaataa agtatggttc ataaatttta ccttgtaagt     8160

gcctaagaaa tgagactaca agctccattt cagcaggaca caataaatat tattttataa     8220

tgcatctaaa aaaaaaaaaa aaaaa                                           8245


<210> 205
<211> 328
<212> PRT
<213> Homo sapiens

<400> 205
Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Asp Ala Ala 
                245                 250                 255     


Ser Lys Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln 
            260                 265                 270         


Pro Ala Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu 
        275                 280                 285             


Pro Ser Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe 
    290                 295                 300                 


Ala Asp Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly 
305                 310                 315                 320 


Thr Ser Ser Tyr Glu Ile Val Ile 
                325             


<210> 206
<211> 8147
<212> DNA
<213> Homo sapiens

<400> 206
ggaggaagaa aactcaagtg aaactgactc tgctagaaca gtgccgtgct tttccacaga       60

aggttagacc ctgaaagaga tggctcagca ccacctatgg atcttgctcc tttgcctgca      120

aacctggccg gaagcagctg gaaaagactc agaaatcttc acagtgaatg ggattctggg      180

agagtcagtc actttccctg taaatatcca agaaccacgg caagttaaaa tcattgcttg      240

gacttctaaa acatctgttg cttatgtaac accaggagac tcagaaacag cacccgtagt      300

tactgtgacc cacagaaatt attatgaacg gatacatgcc ttaggtccga actacaatct      360

ggtcattagc gatctgagga tggaagacgc aggagactac aaagcagaca taaatacaca      420

ggctgatccc tacaccacca ccaagcgcta caacctgcaa atctatcgtc ggcttgggaa      480

accaaaaatt acacagagtt taatggcatc tgtgaacagc acctgtaatg tcacactgac      540

atgctctgta gagaaagaag aaaagaatgt gacatacaat tggagtcccc tgggagaaga      600

gggtaatgtc cttcaaatct tccagactcc tgaggaccaa gagctgactt acacgtgtac      660

agcccagaac cctgtcagca acaattctga ctccatctct gcccggcagc tctgtgcaga      720

catcgcaatg ggcttccgta ctcaccacac cgggttgctg agcgtgctgg ctatgttctt      780

tctgcttgtt ctcattctgt cttcagtgtt tttgttccgt ttgttcaaga gaagacaagg      840

tgcttccctc caaggaagag ccagtgaaca cagtttattc cgaagtgcag tttgctgata      900

agatggggaa agccagcaca caggacagta aacctcctgg gacttcaagc tatgaaattg      960

tgatctaggc tgctgggctg aattctccct ctggaaactg agttacaacc accaatactg     1020

gcaggttccc tggatccaga tcttctctgc ccaactctta ctgggagatt gcaaactgcc     1080

acatctcagc ctgtaagcaa agcaggaaac cttctgctgg gcatagcttg tgcctaaatg     1140

gacaaatgga tgcataccct tcctgaaatg actcccttct gaatgaatga caaagcaggt     1200

tacctagtat agttttccca aacttcttcc catcatagca catgtagaaa ataatatttt     1260

tatggcacac tgggataaac aagcaagatt gctcacttct ggaagctgca tatgactaga     1320

ggcctcttgt gactggaggt aacaaccctg cccagtaact gtgggagaag gggatcaata     1380

ttttgcacac ctgtaatagg ccatggcaca ccagccaaga tgctctgctc acagtcagta     1440

tgtgtgaaga tccctggtgc gtggccttca ccacgcatct tgagcaaatt aggaaaatgt     1500

acccttcgct tgaggcagat gcagcccttc ccccgagtgc atggcttgga gagcagaatg     1560

tgggctgcat ataagcacac tcatcccttt gtctgggaat ctttgtgcag ggcataacag     1620

gcttagtaag tccaaacaca gatgacagtg ctgtgtgggt ctctgtcaga gttgtggctc     1680

tcagccatgt agacacactc tccaaatgga gtgttggaaa atgttctttc tgcagggtct     1740

agagactgct gggacacttt tcttggagtg ctacttcaga agccttatag gattttcttt     1800

ctggccaaga tttccttctg tatcactcca agcagcctca gcagaagaag cagccatgcc     1860

cagtattccc actctccaaa aggaactgac cagcttatat ttctcacact tctggggaac     1920

tgggtataat ccaaccatca aaatagaaga ccttgcaaga agcagagtca ttctccagaa     1980

ggaacttggg agatgatggt gcagatgatg aaactgggtt catcccagtt ccaaagactc     2040

agagaactag agtttaagct gaggcagagt gccgccaccc tggcatgccc cacaaacaga     2100

tcaccagcca gcttacacag gcattaactc tcctcaatga ggaagaatca ttcacaactg     2160

agcaagacat tcatatgatc atttaaggaa gtgtttccct tatgtgttag caagtataat     2220

cggctaactc ctaaatccca atgaatagtc ctaggctgga cagcaatggg ctgcaattag     2280

gcagataaag acatcagtcc cagtaaatga atccatagac tcatctagca ccaactacca     2340

ttagcactat gttaggagct gcaaggcccc aaagtagaag atgtgcataa tgtctgctct     2400

tgtgtagctc aggagacaat tccagcacag acactacagt taacgctgaa ctgcagctgc     2460

aagtaatagc atgaacagtc agaaaaatac cttatgaggg ggcagggctg aagctgggcc     2520

ttgaaggatg gatgaaattt ggatagagaa tgaggaagac agagggcctc caagtgagag     2580

aagcatgaaa aatgagcagg ggcctggatc agtggggtgt attcagagca cctctccaga     2640

tgcaccatgc atgctcacag tcccttgcct atgtgtggca gagtgtccca gccagatgtg     2700

tgccctcacc ccatgtccat ttacatgtcc ttcaatgccc acctcaaaag gtacctcttc     2760

tgtaaagctt tccctggtat caggaatcaa aattaatcag ggatcttttc acactgctgt     2820

tttttcctct ttggtccttc tatcactaaa actcatctca ttcagcctta cagcataact     2880

aattatttgt tttcctcact acattgtaca tgtgggaatt acagataaac ggaagccggc     2940

tggggtggtg gctcacgcct gtaatcccaa cactttggga ggccaaggca ggcggatcac     3000

ctgaggtcag gagttcgaga ttagtctggc caacatggtg aaaccccatc tctactaaaa     3060

atacgaaatt agccaggtgt ggtggcacac atctgtagtc ccagctactc tggaggctga     3120

gacaggagaa tcgcttgaac ccaggaagtg gaggttgcag tgagctgaga tcacaccact     3180

gcactccagc ctgggagaga cagagtgaga ctccatctcg aaaaaaaaaa aaagatagaa     3240

gccaataagc atggtgcaat caaattctgg caagcattaa atatcaggat gcagctgggc     3300

acggtggctc acgcctgtaa tcccagcact ttgggaggcc aaggtgggcg gatcacttga     3360

ggtcaggaat ttgagaggat cctggccagc atggcaaaac cccatctgta cttaaaatac     3420

aaaaaaatta gctgggcgtg gtggtgcaca cctgtaatcc cagctacttg ggaggctgag     3480

gtgggagaat tgcttgaacc tgggaggtgg aggttgcagt gagctgagat cctgccactg     3540

cactccaggc tgggcaacag agtgagacca tgtctcaaaa aataaaaata aaataaaata     3600

atatcaggat gcatacatca gaggctgttc ctagtgtaaa ggcactttgg agggagaaga     3660

ctttcagagt taggcagacc aactaagagg tcagctgaag cacctaacca gttgtaagga     3720

ggtgaaagac agcaccccaa gaagagacgt gcaggaagga ggaaagaggc ttggtcataa     3780

aggatggagg aattccaaag tgacactgaa caggctgcgt ttatcctaaa ataaaaccac     3840

tcctcactct gtggatgcgt tgaagactca ttcccaaaca tctttattct ctaacttgcc     3900

ctcttcctct tcctaatatg ctcactcaag taaaattact agtgtcctaa tgcccctatg     3960

catattgtca aaaataaaaa tcagaagcag gttagatctg ttaggtcttc cagaagagca     4020

aacctgggat gaagccagag cccaggaatt ctgaaggtag cctttggact caggacaccc     4080

tactcttgtc tctcctctca gtttctctgc tatgaatctc ctgattcatg aacacgttat     4140

ctgttcaccc ttctctctag gtcttagttc ttagattttc cttctgtaaa atgcatgtga     4200

tcttattttc ccctccacaa ctttccagat gaactagact gtgaccaaga ggtctataaa     4260

atcaaagcat catggaacag gatcttgtat cagaccaaag tgtgccagtt tttaaaaatg     4320

tgcatcaaaa tggaagtctc agagacagag ccctctggtg gaaagttcta gtaggttagg     4380

acagtcctgc ctgcagacac cttgggcttt actgagggac tcaactgaga aaatgaggaa     4440

tgttgcagct catgattctt agaagaagaa agtgaagctt gtttaaaata tgatttaaaa     4500

aatctgtaga acactgtaaa ctacacaggc tatgagggaa tagcctggtt gggccagctt     4560

ggaaatcggg cacaggcagg aaggggcctg tctggtttgg gccgtgtcca cagagagcac     4620

ttcttaggtc ctgcctggag agaaggaatg gctgggctat attttcttcc agactcatta     4680

tttttcttct gtttgacttt tctctgaatt tcccttgatt tgtataaatt ttctcaataa     4740

ttagtgacag tgtctactga ttgtaaaatg aagcttgaag gccaggcgca gtggctcatg     4800

cctgtaatcc tagaattttg ggaggccaag gtgggtggat cacaaggagt tcgagaccag     4860

cctggccaag gttgtgaaac cgcgtctcta ctaaaaatac aaaaaaatta gccgggcatg     4920

gtggcacgtg cctgtagtcc cagctactca ggaagctgag gcaacagaat cacttgaacc     4980

tgggaggtgg aggttgcagt gagccgagat cacgccactg cactccagcc tgggcgagag     5040

agtgagactc cgtctcaaaa aaaaaaaaaa aaaaaaaagt ttgaagaaca aagacaataa     5100

gaggaaatat aatgagtggt cataaatgtg ggctctgaca gtagagtgcc tgggtctgca     5160

tcctggtttc ttagtcatgt gaccttaggc aagttacttt aacctcgctg tacctcaggt     5220

tgtccatctg taaaatgggg ataataatag tgcctacctt ttaaggttga tgtggggatt     5280

aaatgaggtg ttgctcatac aggaatgtgc ctgtgcatgg caaagttcgg gaaatttttt     5340

ataagctgtt ctaggcctga aatcttcaga agatgctaat ctaaattcat gaaataagct     5400

tcttacaaca gaaatgctgc tagtattatg caaaattaat gttgtatatc aaacttttaa     5460

ctctcatccc tccttattca gatatatttt gttataagca atgtttgttc ccctcgttat     5520

tataccacag tctacttacc tgatgctata tctgcctccc cagttagact gagagaacag     5580

gggatatacc taaataataa taataataat aataataata aataataatg gagagctcct     5640

tgaagatagg gagcctgtaa gaatcattga gggcttattt tgtataccaa ctgctaaact     5700

agatgcttca tacattgttg tcaatactca tgacagcctt gtaaagtaga aattaattct     5760

tccagttaac actaaggctg acatatgaat accttggcaa atctggaaag ctgggaagac     5820

agtatttgaa ttcaagactt cttgtcacca agggccatgc acttgtactc tgccatgtgg     5880

ccctttttta cctcctgtgg attctcccta cctggtactt ggccttaggt gtacacacac     5940

ctggcacttt gcttgacaca taataggtgg accacaaata tctactaaat gaatatttgc     6000

atatagtaat attttaaggt actaaaagca gctcaaagta aatatattaa tatattaatt     6060

ccattgctat ctggataacc actcaacttt cctgctgaaa atgcccattt aattaaagaa     6120

ggttggatag agctctctat atgcattttg gacaggcagg ggtttcaggt cataaacatt     6180

ctgatgagtt aatataaaat aagagaaact gtaaatttcc actactaaaa atcacaaaaa     6240

taacagaaac aaaagaagag ataagaattt ggggaattgt gctgaacaat ttagtggtta     6300

aaaaaaacaa ctgtgcatgt ttagacttaa ataagccccc atccaagtgt gaggggtcca     6360

gtaatttttc aaaacatatg aaagtgttaa tacatttcga caaaggacca ttaaaaaagt     6420

cctgaattct gacttgaggg aggaaagtaa tgactaatac attctctaga gacttgcaga     6480

ctttgggaat tcataaagga atggatgata attattaact gttgctggct gattgcccag     6540

acagttctca acagccctgt acaagtctct gggtttggga tggatcaatt ctgagactgg     6600

aaaatggcca aatctttgca aatgagaaat atttttctta taagttctta ttgtaggcaa     6660

ataattacat agattattca tcagagaatt tttaaatgct cataatctca actctttcat     6720

ttacaacttg tatttccaat agtttatggg tcatctctgc atagatgtca gaagtcacct     6780

caagtttagc gtgtccaaaa tctaactcac aggtctgttt ctgacctccc aacttgcttt     6840

ccttgtgttt ttcctatgct aatgatccac cataatcaaa ataattaaca tttatccagt     6900

gcctactatg tactattccc tgtcctgttt tacatttact catttaaagt ccataagaaa     6960

cattaaatct catctgcctt ctgaagaaga tacaaccatg ctctctttta caaagtagga     7020

aactgggtca cagaaaggtg aagtctttaa ggctgaatca cagtagctca tcctagtaaa     7080

tagaaaagcc aggattcaac tccaggggct gggtgcagaa ctgctattct tcactgcttc     7140

accaatcagc agctacccaa ggcagaaaac tttttcatcc ttggctcctt cattctccct     7200

gtcaccccag atcccctcta catctagtca gagaataggt cctgtcaatt ccaacttctc     7260

tatatggctc ctctcaggca tgtgccctta attggcctaa ttctctaata caccttccct     7320

ctacatgctc actccctcag atcattgctt tatcacgtgt tacctgggtt gctattacat     7380

aaagagcaat ctttctaaaa tgaggatctt atcacttcac ttccacacta aaatgttttt     7440

cctggggaac cacactcctt agcaatctga cccatcagac cttccaggct gtctcctgcc     7500

tgctccctaa ggctccagcc acacagaatt atcatgggcc cacacaccca ccaaatcctc     7560

ccatgccttt gcccatgttg tctgggatgc ccttctctcc cttctgtcta catcaagcat     7620

cagactgaat atccctcttg tgcggccttc taaaacctcc cgtccaaagc gaaatatatt     7680

gccctctatt tatactttta cagcatttgg cacacaagta cagagtagta gctttttatc     7740

acattctctg ataattatat agatatggta tttcttagct ctctctccaa ctggctaata     7800

agttgctttt tgtctgagtg cctaattttg tgttttgtgt ctgagtgcct cagttcctca     7860

aaaaaaggtt ttttgattag ttcattattc atttgaacat ggaaattatg ctcactagtg     7920

gcaaatgcca ctaaccgtat tccagaagct aggtgtcatg tttgcaataa gatatattat     7980

cccttctaca agtcaccttt tatttcaggc atttgtaaat gcccattaat aaagtatggt     8040

tcataaattt taccttgtaa gtgcctaaga aatgagacta caagctccat ttcagcagga     8100

cacaataaat attattttat aatgcatcta aaaaaaaaaa aaaaaaa                   8147


<210> 207
<211> 272
<212> PRT
<213> Homo sapiens

<400> 207
Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Gly Ala Ser 
                245                 250                 255     


Leu Gln Gly Arg Ala Ser Glu His Ser Leu Phe Arg Ser Ala Val Cys 
            260                 265                 270         


<210> 208
<211> 7903
<212> DNA
<213> Homo sapiens

<400> 208
ggaggaagaa aactcaagtg aaactgactc tgctagaaca gtgccgtgct tttccacaga       60

aggttagacc ctgaaagaga tggctcagca ccacctatgg atcttgctcc tttgcctgca      120

aacctgtcgg cttgggaaac caaaaattac acagagttta atggcatctg tgaacagcac      180

ctgtaatgtc acactgacat gctctgtaga gaaagaagaa aagaatgtga catacaattg      240

gagtcccctg ggagaagagg gtaatgtcct tcaaatcttc cagactcctg aggaccaaga      300

gctgacttac acgtgtacag cccagaaccc tgtcagcaac aattctgact ccatctctgc      360

ccggcagctc tgtgcagaca tcgcaatggg cttccgtact caccacaccg ggttgctgag      420

cgtgctggct atgttctttc tgcttgttct cattctgtct tcagtgtttt tgttccgttt      480

gttcaagaga agacaagatg ctgcctcaaa gaaaaccata tacacatata tcatggcttc      540

aaggaacacc cagccagcag agtccagaat ctatgatgaa atcctgcagt ccaaggtgct      600

tccctccaag gaagagccag tgaacacagt ttattccgaa gtgcagtttg ctgataagat      660

ggggaaagcc agcacacagg acagtaaacc tcctgggact tcaagctatg aaattgtgat      720

ctaggctgct gggctgaatt ctccctctgg aaactgagtt acaaccacca atactggcag      780

gttccctgga tccagatctt ctctgcccaa ctcttactgg gagattgcaa actgccacat      840

ctcagcctgt aagcaaagca ggaaaccttc tgctgggcat agcttgtgcc taaatggaca      900

aatggatgca tacccttcct gaaatgactc ccttctgaat gaatgacaaa gcaggttacc      960

tagtatagtt ttcccaaact tcttcccatc atagcacatg tagaaaataa tatttttatg     1020

gcacactggg ataaacaagc aagattgctc acttctggaa gctgcatatg actagaggcc     1080

tcttgtgact ggaggtaaca accctgccca gtaactgtgg gagaagggga tcaatatttt     1140

gcacacctgt aataggccat ggcacaccag ccaagatgct ctgctcacag tcagtatgtg     1200

tgaagatccc tggtgcgtgg ccttcaccac gcatcttgag caaattagga aaatgtaccc     1260

ttcgcttgag gcagatgcag cccttccccc gagtgcatgg cttggagagc agaatgtggg     1320

ctgcatataa gcacactcat ccctttgtct gggaatcttt gtgcagggca taacaggctt     1380

agtaagtcca aacacagatg acagtgctgt gtgggtctct gtcagagttg tggctctcag     1440

ccatgtagac acactctcca aatggagtgt tggaaaatgt tctttctgca gggtctagag     1500

actgctggga cacttttctt ggagtgctac ttcagaagcc ttataggatt ttctttctgg     1560

ccaagatttc cttctgtatc actccaagca gcctcagcag aagaagcagc catgcccagt     1620

attcccactc tccaaaagga actgaccagc ttatatttct cacacttctg gggaactggg     1680

tataatccaa ccatcaaaat agaagacctt gcaagaagca gagtcattct ccagaaggaa     1740

cttgggagat gatggtgcag atgatgaaac tgggttcatc ccagttccaa agactcagag     1800

aactagagtt taagctgagg cagagtgccg ccaccctggc atgccccaca aacagatcac     1860

cagccagctt acacaggcat taactctcct caatgaggaa gaatcattca caactgagca     1920

agacattcat atgatcattt aaggaagtgt ttcccttatg tgttagcaag tataatcggc     1980

taactcctaa atcccaatga atagtcctag gctggacagc aatgggctgc aattaggcag     2040

ataaagacat cagtcccagt aaatgaatcc atagactcat ctagcaccaa ctaccattag     2100

cactatgtta ggagctgcaa ggccccaaag tagaagatgt gcataatgtc tgctcttgtg     2160

tagctcagga gacaattcca gcacagacac tacagttaac gctgaactgc agctgcaagt     2220

aatagcatga acagtcagaa aaatacctta tgagggggca gggctgaagc tgggccttga     2280

aggatggatg aaatttggat agagaatgag gaagacagag ggcctccaag tgagagaagc     2340

atgaaaaatg agcaggggcc tggatcagtg gggtgtattc agagcacctc tccagatgca     2400

ccatgcatgc tcacagtccc ttgcctatgt gtggcagagt gtcccagcca gatgtgtgcc     2460

ctcaccccat gtccatttac atgtccttca atgcccacct caaaaggtac ctcttctgta     2520

aagctttccc tggtatcagg aatcaaaatt aatcagggat cttttcacac tgctgttttt     2580

tcctctttgg tccttctatc actaaaactc atctcattca gccttacagc ataactaatt     2640

atttgttttc ctcactacat tgtacatgtg ggaattacag ataaacggaa gccggctggg     2700

gtggtggctc acgcctgtaa tcccaacact ttgggaggcc aaggcaggcg gatcacctga     2760

ggtcaggagt tcgagattag tctggccaac atggtgaaac cccatctcta ctaaaaatac     2820

gaaattagcc aggtgtggtg gcacacatct gtagtcccag ctactctgga ggctgagaca     2880

ggagaatcgc ttgaacccag gaagtggagg ttgcagtgag ctgagatcac accactgcac     2940

tccagcctgg gagagacaga gtgagactcc atctcgaaaa aaaaaaaaag atagaagcca     3000

ataagcatgg tgcaatcaaa ttctggcaag cattaaatat caggatgcag ctgggcacgg     3060

tggctcacgc ctgtaatccc agcactttgg gaggccaagg tgggcggatc acttgaggtc     3120

aggaatttga gaggatcctg gccagcatgg caaaacccca tctgtactta aaatacaaaa     3180

aaattagctg ggcgtggtgg tgcacacctg taatcccagc tacttgggag gctgaggtgg     3240

gagaattgct tgaacctggg aggtggaggt tgcagtgagc tgagatcctg ccactgcact     3300

ccaggctggg caacagagtg agaccatgtc tcaaaaaata aaaataaaat aaaataatat     3360

caggatgcat acatcagagg ctgttcctag tgtaaaggca ctttggaggg agaagacttt     3420

cagagttagg cagaccaact aagaggtcag ctgaagcacc taaccagttg taaggaggtg     3480

aaagacagca ccccaagaag agacgtgcag gaaggaggaa agaggcttgg tcataaagga     3540

tggaggaatt ccaaagtgac actgaacagg ctgcgtttat cctaaaataa aaccactcct     3600

cactctgtgg atgcgttgaa gactcattcc caaacatctt tattctctaa cttgccctct     3660

tcctcttcct aatatgctca ctcaagtaaa attactagtg tcctaatgcc cctatgcata     3720

ttgtcaaaaa taaaaatcag aagcaggtta gatctgttag gtcttccaga agagcaaacc     3780

tgggatgaag ccagagccca ggaattctga aggtagcctt tggactcagg acaccctact     3840

cttgtctctc ctctcagttt ctctgctatg aatctcctga ttcatgaaca cgttatctgt     3900

tcacccttct ctctaggtct tagttcttag attttccttc tgtaaaatgc atgtgatctt     3960

attttcccct ccacaacttt ccagatgaac tagactgtga ccaagaggtc tataaaatca     4020

aagcatcatg gaacaggatc ttgtatcaga ccaaagtgtg ccagttttta aaaatgtgca     4080

tcaaaatgga agtctcagag acagagccct ctggtggaaa gttctagtag gttaggacag     4140

tcctgcctgc agacaccttg ggctttactg agggactcaa ctgagaaaat gaggaatgtt     4200

gcagctcatg attcttagaa gaagaaagtg aagcttgttt aaaatatgat ttaaaaaatc     4260

tgtagaacac tgtaaactac acaggctatg agggaatagc ctggttgggc cagcttggaa     4320

atcgggcaca ggcaggaagg ggcctgtctg gtttgggccg tgtccacaga gagcacttct     4380

taggtcctgc ctggagagaa ggaatggctg ggctatattt tcttccagac tcattatttt     4440

tcttctgttt gacttttctc tgaatttccc ttgatttgta taaattttct caataattag     4500

tgacagtgtc tactgattgt aaaatgaagc ttgaaggcca ggcgcagtgg ctcatgcctg     4560

taatcctaga attttgggag gccaaggtgg gtggatcaca aggagttcga gaccagcctg     4620

gccaaggttg tgaaaccgcg tctctactaa aaatacaaaa aaattagccg ggcatggtgg     4680

cacgtgcctg tagtcccagc tactcaggaa gctgaggcaa cagaatcact tgaacctggg     4740

aggtggaggt tgcagtgagc cgagatcacg ccactgcact ccagcctggg cgagagagtg     4800

agactccgtc tcaaaaaaaa aaaaaaaaaa aaaagtttga agaacaaaga caataagagg     4860

aaatataatg agtggtcata aatgtgggct ctgacagtag agtgcctggg tctgcatcct     4920

ggtttcttag tcatgtgacc ttaggcaagt tactttaacc tcgctgtacc tcaggttgtc     4980

catctgtaaa atggggataa taatagtgcc taccttttaa ggttgatgtg gggattaaat     5040

gaggtgttgc tcatacagga atgtgcctgt gcatggcaaa gttcgggaaa ttttttataa     5100

gctgttctag gcctgaaatc ttcagaagat gctaatctaa attcatgaaa taagcttctt     5160

acaacagaaa tgctgctagt attatgcaaa attaatgttg tatatcaaac ttttaactct     5220

catccctcct tattcagata tattttgtta taagcaatgt ttgttcccct cgttattata     5280

ccacagtcta cttacctgat gctatatctg cctccccagt tagactgaga gaacagggga     5340

tatacctaaa taataataat aataataata ataataaata ataatggaga gctccttgaa     5400

gatagggagc ctgtaagaat cattgagggc ttattttgta taccaactgc taaactagat     5460

gcttcataca ttgttgtcaa tactcatgac agccttgtaa agtagaaatt aattcttcca     5520

gttaacacta aggctgacat atgaatacct tggcaaatct ggaaagctgg gaagacagta     5580

tttgaattca agacttcttg tcaccaaggg ccatgcactt gtactctgcc atgtggccct     5640

tttttacctc ctgtggattc tccctacctg gtacttggcc ttaggtgtac acacacctgg     5700

cactttgctt gacacataat aggtggacca caaatatcta ctaaatgaat atttgcatat     5760

agtaatattt taaggtacta aaagcagctc aaagtaaata tattaatata ttaattccat     5820

tgctatctgg ataaccactc aactttcctg ctgaaaatgc ccatttaatt aaagaaggtt     5880

ggatagagct ctctatatgc attttggaca ggcaggggtt tcaggtcata aacattctga     5940

tgagttaata taaaataaga gaaactgtaa atttccacta ctaaaaatca caaaaataac     6000

agaaacaaaa gaagagataa gaatttgggg aattgtgctg aacaatttag tggttaaaaa     6060

aaacaactgt gcatgtttag acttaaataa gcccccatcc aagtgtgagg ggtccagtaa     6120

tttttcaaaa catatgaaag tgttaataca tttcgacaaa ggaccattaa aaaagtcctg     6180

aattctgact tgagggagga aagtaatgac taatacattc tctagagact tgcagacttt     6240

gggaattcat aaaggaatgg atgataatta ttaactgttg ctggctgatt gcccagacag     6300

ttctcaacag ccctgtacaa gtctctgggt ttgggatgga tcaattctga gactggaaaa     6360

tggccaaatc tttgcaaatg agaaatattt ttcttataag ttcttattgt aggcaaataa     6420

ttacatagat tattcatcag agaattttta aatgctcata atctcaactc tttcatttac     6480

aacttgtatt tccaatagtt tatgggtcat ctctgcatag atgtcagaag tcacctcaag     6540

tttagcgtgt ccaaaatcta actcacaggt ctgtttctga cctcccaact tgctttcctt     6600

gtgtttttcc tatgctaatg atccaccata atcaaaataa ttaacattta tccagtgcct     6660

actatgtact attccctgtc ctgttttaca tttactcatt taaagtccat aagaaacatt     6720

aaatctcatc tgccttctga agaagataca accatgctct cttttacaaa gtaggaaact     6780

gggtcacaga aaggtgaagt ctttaaggct gaatcacagt agctcatcct agtaaataga     6840

aaagccagga ttcaactcca ggggctgggt gcagaactgc tattcttcac tgcttcacca     6900

atcagcagct acccaaggca gaaaactttt tcatccttgg ctccttcatt ctccctgtca     6960

ccccagatcc cctctacatc tagtcagaga ataggtcctg tcaattccaa cttctctata     7020

tggctcctct caggcatgtg cccttaattg gcctaattct ctaatacacc ttccctctac     7080

atgctcactc cctcagatca ttgctttatc acgtgttacc tgggttgcta ttacataaag     7140

agcaatcttt ctaaaatgag gatcttatca cttcacttcc acactaaaat gtttttcctg     7200

gggaaccaca ctccttagca atctgaccca tcagaccttc caggctgtct cctgcctgct     7260

ccctaaggct ccagccacac agaattatca tgggcccaca cacccaccaa atcctcccat     7320

gcctttgccc atgttgtctg ggatgccctt ctctcccttc tgtctacatc aagcatcaga     7380

ctgaatatcc ctcttgtgcg gccttctaaa acctcccgtc caaagcgaaa tatattgccc     7440

tctatttata cttttacagc atttggcaca caagtacaga gtagtagctt tttatcacat     7500

tctctgataa ttatatagat atggtatttc ttagctctct ctccaactgg ctaataagtt     7560

gctttttgtc tgagtgccta attttgtgtt ttgtgtctga gtgcctcagt tcctcaaaaa     7620

aaggtttttt gattagttca ttattcattt gaacatggaa attatgctca ctagtggcaa     7680

atgccactaa ccgtattcca gaagctaggt gtcatgtttg caataagata tattatccct     7740

tctacaagtc accttttatt tcaggcattt gtaaatgccc attaataaag tatggttcat     7800

aaattttacc ttgtaagtgc ctaagaaatg agactacaag ctccatttca gcaggacaca     7860

ataaatatta ttttataatg catctaaaaa aaaaaaaaaa aaa                       7903


<210> 209
<211> 214
<212> PRT
<213> Homo sapiens

<400> 209
Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Cys 
1               5                   10                  15      


Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser Val Asn 
            20                  25                  30          


Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu Glu Lys 
        35                  40                  45              


Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn Val Leu 
    50                  55                  60                  


Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr Cys Thr 
65                  70                  75                  80  


Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala Arg Gln 
                85                  90                  95      


Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr Gly Leu 
            100                 105                 110         


Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu Ser Ser 
        115                 120                 125             


Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Asp Ala Ala Ser Lys 
    130                 135                 140                 


Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln Pro Ala 
145                 150                 155                 160 


Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu Pro Ser 
                165                 170                 175     


Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe Ala Asp 
            180                 185                 190         


Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly Thr Ser 
        195                 200                 205             


Ser Tyr Glu Ile Val Ile 
    210                 


<210> 210
<211> 8261
<212> DNA
<213> Homo sapiens

<400> 210
ggaggaagaa aactcaagtg aaactgactc tgctagaaca gtgccgtgct tttccacaga       60

aggttagacc ctgaaagaga tggctcagca ccacctatgg atcttgctcc tttgcctgca      120

aacctggccg gaagcagctg gaaaagactc agaaatcttc acagtgaatg ggattctggg      180

agagtcagtc actttccctg taaatatcca agaaccacgg caagttaaaa tcattgcttg      240

gacttctaaa acatctgttg cttatgtaac accaggagac tcagaaacag cacccgtagt      300

tactgtgacc cacagaaatt attatgaacg gatacatgcc ttaggtccga actacaatct      360

ggtcattagc gatctgagga tggaagacgc aggagactac aaagcagaca taaatacaca      420

ggctgatccc tacaccacca ccaagcgcta caacctgcaa atctatcgtc ggcttgggaa      480

accaaaaatt acacagagtt taatggcatc tgtgaacagc acctgtaatg tcacactgac      540

atgctctgta gagaaagaag aaaagaatgt gacatacaat tggagtcccc tgggagaaga      600

gggtaatgtc cttcaaatct tccagactcc tgaggaccaa gagctgactt acacgtgtac      660

agcccagaac cctgtcagca acaattctga ctccatctct gcccggcagc tctgtgcaga      720

catcgcaatg ggcttccgta ctcaccacac cgggttgctg agcgtgctgg ctatgttctt      780

tctgcttgtt ctcattctgt cttcagtgtt tttgttccgt ttgttcaaga gaagacaagg      840

ttcctgcttg aacaccttca ctaagaaccc ttatgctgcc tcaaagaaaa ccatatacac      900

atatatcatg gcttcaagga acacccagcc agcagagtcc agaatctatg atgaaatcct      960

gcagtccaag gtgcttccct ccaaggaaga gccagtgaac acagtttatt ccgaagtgca     1020

gtttgctgat aagatgggga aagccagcac acaggacagt aaacctcctg ggacttcaag     1080

ctatgaaatt gtgatctagg ctgctgggct gaattctccc tctggaaact gagttacaac     1140

caccaatact ggcaggttcc ctggatccag atcttctctg cccaactctt actgggagat     1200

tgcaaactgc cacatctcag cctgtaagca aagcaggaaa ccttctgctg ggcatagctt     1260

gtgcctaaat ggacaaatgg atgcataccc ttcctgaaat gactcccttc tgaatgaatg     1320

acaaagcagg ttacctagta tagttttccc aaacttcttc ccatcatagc acatgtagaa     1380

aataatattt ttatggcaca ctgggataaa caagcaagat tgctcacttc tggaagctgc     1440

atatgactag aggcctcttg tgactggagg taacaaccct gcccagtaac tgtgggagaa     1500

ggggatcaat attttgcaca cctgtaatag gccatggcac accagccaag atgctctgct     1560

cacagtcagt atgtgtgaag atccctggtg cgtggccttc accacgcatc ttgagcaaat     1620

taggaaaatg tacccttcgc ttgaggcaga tgcagccctt cccccgagtg catggcttgg     1680

agagcagaat gtgggctgca tataagcaca ctcatccctt tgtctgggaa tctttgtgca     1740

gggcataaca ggcttagtaa gtccaaacac agatgacagt gctgtgtggg tctctgtcag     1800

agttgtggct ctcagccatg tagacacact ctccaaatgg agtgttggaa aatgttcttt     1860

ctgcagggtc tagagactgc tgggacactt ttcttggagt gctacttcag aagccttata     1920

ggattttctt tctggccaag atttccttct gtatcactcc aagcagcctc agcagaagaa     1980

gcagccatgc ccagtattcc cactctccaa aaggaactga ccagcttata tttctcacac     2040

ttctggggaa ctgggtataa tccaaccatc aaaatagaag accttgcaag aagcagagtc     2100

attctccaga aggaacttgg gagatgatgg tgcagatgat gaaactgggt tcatcccagt     2160

tccaaagact cagagaacta gagtttaagc tgaggcagag tgccgccacc ctggcatgcc     2220

ccacaaacag atcaccagcc agcttacaca ggcattaact ctcctcaatg aggaagaatc     2280

attcacaact gagcaagaca ttcatatgat catttaagga agtgtttccc ttatgtgtta     2340

gcaagtataa tcggctaact cctaaatccc aatgaatagt cctaggctgg acagcaatgg     2400

gctgcaatta ggcagataaa gacatcagtc ccagtaaatg aatccataga ctcatctagc     2460

accaactacc attagcacta tgttaggagc tgcaaggccc caaagtagaa gatgtgcata     2520

atgtctgctc ttgtgtagct caggagacaa ttccagcaca gacactacag ttaacgctga     2580

actgcagctg caagtaatag catgaacagt cagaaaaata ccttatgagg gggcagggct     2640

gaagctgggc cttgaaggat ggatgaaatt tggatagaga atgaggaaga cagagggcct     2700

ccaagtgaga gaagcatgaa aaatgagcag gggcctggat cagtggggtg tattcagagc     2760

acctctccag atgcaccatg catgctcaca gtcccttgcc tatgtgtggc agagtgtccc     2820

agccagatgt gtgccctcac cccatgtcca tttacatgtc cttcaatgcc cacctcaaaa     2880

ggtacctctt ctgtaaagct ttccctggta tcaggaatca aaattaatca gggatctttt     2940

cacactgctg ttttttcctc tttggtcctt ctatcactaa aactcatctc attcagcctt     3000

acagcataac taattatttg ttttcctcac tacattgtac atgtgggaat tacagataaa     3060

cggaagccgg ctggggtggt ggctcacgcc tgtaatccca acactttggg aggccaaggc     3120

aggcggatca cctgaggtca ggagttcgag attagtctgg ccaacatggt gaaaccccat     3180

ctctactaaa aatacgaaat tagccaggtg tggtggcaca catctgtagt cccagctact     3240

ctggaggctg agacaggaga atcgcttgaa cccaggaagt ggaggttgca gtgagctgag     3300

atcacaccac tgcactccag cctgggagag acagagtgag actccatctc gaaaaaaaaa     3360

aaaagataga agccaataag catggtgcaa tcaaattctg gcaagcatta aatatcagga     3420

tgcagctggg cacggtggct cacgcctgta atcccagcac tttgggaggc caaggtgggc     3480

ggatcacttg aggtcaggaa tttgagagga tcctggccag catggcaaaa ccccatctgt     3540

acttaaaata caaaaaaatt agctgggcgt ggtggtgcac acctgtaatc ccagctactt     3600

gggaggctga ggtgggagaa ttgcttgaac ctgggaggtg gaggttgcag tgagctgaga     3660

tcctgccact gcactccagg ctgggcaaca gagtgagacc atgtctcaaa aaataaaaat     3720

aaaataaaat aatatcagga tgcatacatc agaggctgtt cctagtgtaa aggcactttg     3780

gagggagaag actttcagag ttaggcagac caactaagag gtcagctgaa gcacctaacc     3840

agttgtaagg aggtgaaaga cagcacccca agaagagacg tgcaggaagg aggaaagagg     3900

cttggtcata aaggatggag gaattccaaa gtgacactga acaggctgcg tttatcctaa     3960

aataaaacca ctcctcactc tgtggatgcg ttgaagactc attcccaaac atctttattc     4020

tctaacttgc cctcttcctc ttcctaatat gctcactcaa gtaaaattac tagtgtccta     4080

atgcccctat gcatattgtc aaaaataaaa atcagaagca ggttagatct gttaggtctt     4140

ccagaagagc aaacctggga tgaagccaga gcccaggaat tctgaaggta gcctttggac     4200

tcaggacacc ctactcttgt ctctcctctc agtttctctg ctatgaatct cctgattcat     4260

gaacacgtta tctgttcacc cttctctcta ggtcttagtt cttagatttt ccttctgtaa     4320

aatgcatgtg atcttatttt cccctccaca actttccaga tgaactagac tgtgaccaag     4380

aggtctataa aatcaaagca tcatggaaca ggatcttgta tcagaccaaa gtgtgccagt     4440

ttttaaaaat gtgcatcaaa atggaagtct cagagacaga gccctctggt ggaaagttct     4500

agtaggttag gacagtcctg cctgcagaca ccttgggctt tactgaggga ctcaactgag     4560

aaaatgagga atgttgcagc tcatgattct tagaagaaga aagtgaagct tgtttaaaat     4620

atgatttaaa aaatctgtag aacactgtaa actacacagg ctatgaggga atagcctggt     4680

tgggccagct tggaaatcgg gcacaggcag gaaggggcct gtctggtttg ggccgtgtcc     4740

acagagagca cttcttaggt cctgcctgga gagaaggaat ggctgggcta tattttcttc     4800

cagactcatt atttttcttc tgtttgactt ttctctgaat ttcccttgat ttgtataaat     4860

tttctcaata attagtgaca gtgtctactg attgtaaaat gaagcttgaa ggccaggcgc     4920

agtggctcat gcctgtaatc ctagaatttt gggaggccaa ggtgggtgga tcacaaggag     4980

ttcgagacca gcctggccaa ggttgtgaaa ccgcgtctct actaaaaata caaaaaaatt     5040

agccgggcat ggtggcacgt gcctgtagtc ccagctactc aggaagctga ggcaacagaa     5100

tcacttgaac ctgggaggtg gaggttgcag tgagccgaga tcacgccact gcactccagc     5160

ctgggcgaga gagtgagact ccgtctcaaa aaaaaaaaaa aaaaaaaaag tttgaagaac     5220

aaagacaata agaggaaata taatgagtgg tcataaatgt gggctctgac agtagagtgc     5280

ctgggtctgc atcctggttt cttagtcatg tgaccttagg caagttactt taacctcgct     5340

gtacctcagg ttgtccatct gtaaaatggg gataataata gtgcctacct tttaaggttg     5400

atgtggggat taaatgaggt gttgctcata caggaatgtg cctgtgcatg gcaaagttcg     5460

ggaaattttt tataagctgt tctaggcctg aaatcttcag aagatgctaa tctaaattca     5520

tgaaataagc ttcttacaac agaaatgctg ctagtattat gcaaaattaa tgttgtatat     5580

caaactttta actctcatcc ctccttattc agatatattt tgttataagc aatgtttgtt     5640

cccctcgtta ttataccaca gtctacttac ctgatgctat atctgcctcc ccagttagac     5700

tgagagaaca ggggatatac ctaaataata ataataataa taataataat aaataataat     5760

ggagagctcc ttgaagatag ggagcctgta agaatcattg agggcttatt ttgtatacca     5820

actgctaaac tagatgcttc atacattgtt gtcaatactc atgacagcct tgtaaagtag     5880

aaattaattc ttccagttaa cactaaggct gacatatgaa taccttggca aatctggaaa     5940

gctgggaaga cagtatttga attcaagact tcttgtcacc aagggccatg cacttgtact     6000

ctgccatgtg gccctttttt acctcctgtg gattctccct acctggtact tggccttagg     6060

tgtacacaca cctggcactt tgcttgacac ataataggtg gaccacaaat atctactaaa     6120

tgaatatttg catatagtaa tattttaagg tactaaaagc agctcaaagt aaatatatta     6180

atatattaat tccattgcta tctggataac cactcaactt tcctgctgaa aatgcccatt     6240

taattaaaga aggttggata gagctctcta tatgcatttt ggacaggcag gggtttcagg     6300

tcataaacat tctgatgagt taatataaaa taagagaaac tgtaaatttc cactactaaa     6360

aatcacaaaa ataacagaaa caaaagaaga gataagaatt tggggaattg tgctgaacaa     6420

tttagtggtt aaaaaaaaca actgtgcatg tttagactta aataagcccc catccaagtg     6480

tgaggggtcc agtaattttt caaaacatat gaaagtgtta atacatttcg acaaaggacc     6540

attaaaaaag tcctgaattc tgacttgagg gaggaaagta atgactaata cattctctag     6600

agacttgcag actttgggaa ttcataaagg aatggatgat aattattaac tgttgctggc     6660

tgattgccca gacagttctc aacagccctg tacaagtctc tgggtttggg atggatcaat     6720

tctgagactg gaaaatggcc aaatctttgc aaatgagaaa tatttttctt ataagttctt     6780

attgtaggca aataattaca tagattattc atcagagaat ttttaaatgc tcataatctc     6840

aactctttca tttacaactt gtatttccaa tagtttatgg gtcatctctg catagatgtc     6900

agaagtcacc tcaagtttag cgtgtccaaa atctaactca caggtctgtt tctgacctcc     6960

caacttgctt tccttgtgtt tttcctatgc taatgatcca ccataatcaa aataattaac     7020

atttatccag tgcctactat gtactattcc ctgtcctgtt ttacatttac tcatttaaag     7080

tccataagaa acattaaatc tcatctgcct tctgaagaag atacaaccat gctctctttt     7140

acaaagtagg aaactgggtc acagaaaggt gaagtcttta aggctgaatc acagtagctc     7200

atcctagtaa atagaaaagc caggattcaa ctccaggggc tgggtgcaga actgctattc     7260

ttcactgctt caccaatcag cagctaccca aggcagaaaa ctttttcatc cttggctcct     7320

tcattctccc tgtcacccca gatcccctct acatctagtc agagaatagg tcctgtcaat     7380

tccaacttct ctatatggct cctctcaggc atgtgccctt aattggccta attctctaat     7440

acaccttccc tctacatgct cactccctca gatcattgct ttatcacgtg ttacctgggt     7500

tgctattaca taaagagcaa tctttctaaa atgaggatct tatcacttca cttccacact     7560

aaaatgtttt tcctggggaa ccacactcct tagcaatctg acccatcaga ccttccaggc     7620

tgtctcctgc ctgctcccta aggctccagc cacacagaat tatcatgggc ccacacaccc     7680

accaaatcct cccatgcctt tgcccatgtt gtctgggatg cccttctctc ccttctgtct     7740

acatcaagca tcagactgaa tatccctctt gtgcggcctt ctaaaacctc ccgtccaaag     7800

cgaaatatat tgccctctat ttatactttt acagcatttg gcacacaagt acagagtagt     7860

agctttttat cacattctct gataattata tagatatggt atttcttagc tctctctcca     7920

actggctaat aagttgcttt ttgtctgagt gcctaatttt gtgttttgtg tctgagtgcc     7980

tcagttcctc aaaaaaaggt tttttgatta gttcattatt catttgaaca tggaaattat     8040

gctcactagt ggcaaatgcc actaaccgta ttccagaagc taggtgtcat gtttgcaata     8100

agatatatta tcccttctac aagtcacctt ttatttcagg catttgtaaa tgcccattaa     8160

taaagtatgg ttcataaatt ttaccttgta agtgcctaag aaatgagact acaagctcca     8220

tttcagcagg acacaataaa tattatttta taatgcatct a                         8261


<210> 211
<211> 339
<212> PRT
<213> Homo sapiens

<400> 211
Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Gly Ser Cys 
                245                 250                 255     


Leu Asn Thr Phe Thr Lys Asn Pro Tyr Ala Ala Ser Lys Lys Thr Ile 
            260                 265                 270         


Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln Pro Ala Glu Ser Arg 
        275                 280                 285             


Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu Pro Ser Lys Glu Glu 
    290                 295                 300                 


Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe Ala Asp Lys Met Gly 
305                 310                 315                 320 


Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly Thr Ser Ser Tyr Glu 
                325                 330                 335     


Ile Val Ile 
            


<210> 212
<211> 3290
<212> DNA
<213> Mus musculus

<400> 212
agtgcttgga gttcctctgt gactgaccac ttcttccttt tctgtctaat ggtgaacacc       60

tttctggacc agctctggac cagaatctga tttatgctct gctccggaaa caccacactg      120

aagtgaaagc agctaccaca ccagttattt ttcctcagaa gactggagtc tgactggaca      180

tggcccagcg ccatctgtgg atctggttcc tttgcctaca aacctggtct gaagcagcag      240

gaaaagatgc agacccggtg gtaatgaatg ggattcttgg ggagtcagtt actttcctct      300

taaatattca agaaccaaag aaaattgaca acattgcctg gacttctcaa tcatctgttg      360

cttttataaa accaggagtc aataaagctg aagttaccat aacccagggc acttataaag      420

gacgaataga aatcatagat cagaagtatg acctggtcat tagagacctg aggatggaag      480

atgcaggaac ttacaaagca gacatcaatg aagagaatga ggaaaccatc accaagatct      540

actaccttca tatctaccgt cgacttaaaa caccaaaaat tacacagagt ttgatatcat      600

ctttgaacaa tacctgtaat atcacactga catgctctgt ggaaaaggaa gaaaaggatg      660

tcacatatag ctggagtccc tttggagaga aaagcaatgt ccttcaaatc gtccactccc      720

ccatggacca aaaactgacc tacacatgta cagcccagaa ccctgtcagc aacagttctg      780

actctgtcac tgtccagcag ccatgtacag acactccaag cttccatcct cgccatgctg      840

tgttgccagg aggattggcc gtgctctttc tgcttattct cattccgatg ttggcatttc      900

tgttccgttt gtataagaga aggcgagaca ggattgtcct ggaagcagat gatgtctcaa      960

agaaaacagt atatgctgta gtttcaagaa atgctcaacc cacagagtcc agaatctatg     1020

atgaaatccc tcagtccaag atgctgtcct gtaagaaaga tccggtgacc accatttatt     1080

cctcagtgca gctttctgag aagatgaagg aaaccaacat gaaggacaga agtctgccta     1140

aggctttggg taatgaaatt gttgtctagg tgattctcta agaccacgaa ggacacaagg     1200

acaagtcatc tatgaggatt gaatcaacgg tttcagtctt ttggatataa cctgggccag     1260

ccaagggatt taggaatgaa gcaagctccg tgggtagagg tctgatcccc agtgtgtaat     1320

gttaggggcc atgtacagga ttgactctca ggcccacaga tctttaccca gagaaaccct     1380

gacctgctcc catgctgttt ttcctgggga aaggacccta gggcactcaa cctttatgca     1440

atcagacatg cctctcagag actgtctaac agcttccaga ctaatctctg tgcagtactt     1500

agtcttacaa ctctcacggg caacggcttc aagttccaat tttacgatgt gtctagcctg     1560

ggatgactgt ttagtttcta atgtggcgag aatgtatgtt accatgtagg aagcacagac     1620

tatggcaatc tataaatgat ttgtggcatg agactgatgt ccgaatttag gggaagggga     1680

atggtcttac ttaggcattt tatggaaatt gagtctctct ccccgagaag agggtgatga     1740

agcagcatcc acgtctgcct cttctccagt aacctgcttg ttatcgacaa tgtccagccg     1800

atggtaatga actgaaacaa atgcgcttga aagagatgaa tcaatttgag atttaacaaa     1860

tcgggtcaat ttctgaaatg cccaaggacc gaaggagatc aataatagga gtcccaatag     1920

gggccctaaa agggagggca acaaggttga aagtcagggg gaggttgaaa accagttttg     1980

gtagtctacc ttccccctag gccattgtaa atacttgtgt atgggtgtaa ctcagctatc     2040

tatagttcta agtatccact ctggttcctc tttaggtctt aaacttcctt cttcctagtt     2100

gatggtaaat tcctgtgtaa ggcagtggcc tagcttttat tcaaagtgat agtgtaatgc     2160

cagaggctat tctgaatgtc actgaatagg caacactctc cctgaattct aagtccatgg     2220

tctgttcaag ggctttttag gacattggaa caccagtgaa ggcttagcta tgtcagaatt     2280

caatcttaaa atgcacttat aataagataa tattaaaaga gagcacatgg atctatacac     2340

cagactaact cgggaataga atatgagtac aaaatgggca gtatgcagct gctgaactaa     2400

ggctgtggta gatacctttt caaagtttgc attcccagat ttttaaacca aggatcgttt     2460

cctaactcta ataggcagca aaacgtaagc aggtctctaa caaaaacata acagtagatt     2520

ccttatctaa attaggatct acacaattag ttaattgaca agaattacaa tgaatataaa     2580

aagacttgcc aagattggcg atcttaactc ttaaaattat ctaacaataa gcatataggt     2640

aaggtacaca aactttcata gctataagga gctgacctga aaggccaaaa acagtgtctc     2700

tgacaaaagc atcttgtaca ttctctgtac cagtcttttt gcctcatgag tcagcttttt     2760

tagttgtttt tattttaagt tggcaccagg ttggtactcc ttgctgcagc ccatggcgga     2820

gatacgaagt ttctttatct gtttgtaagt ggctgctctc tgatttctct tcttttgtat     2880

actcaacata gctttctggt caccactgtc agggcactca caggtcacag gtcagcctgt     2940

cacattggaa gctagcatgc tcttgtagca ttctgtggaa aaaacagaaa cattctccct     3000

tttccccata ttaagtatct gaacaggatc atggcaagtg ccaataagtg gatccttttt     3060

atctgtccta gacatcatta tatctagttt gttttttttt tgtaaataaa aatgtgattt     3120

tatgtgcaca gggatataat tcctaccttc tttgttttta aagaaggtat agtttttaaa     3180

gttttacaat accttgtctt tgagaattat aaaatatctc agtaacatgt gtaacattaa     3240

attgttaaca aaacatctct tggaggtttt gaaaataaaa attttgaagc                3290


<210> 213
<211> 329
<212> PRT
<213> Mus musculus

<400> 213
Met Ala Gln Arg His Leu Trp Ile Trp Phe Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Ser Glu Ala Ala Gly Lys Asp Ala Asp Pro Val Val Met Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Leu Leu Asn Ile Gln Glu Pro Lys Lys 
        35                  40                  45              


Ile Asp Asn Ile Ala Trp Thr Ser Gln Ser Ser Val Ala Phe Ile Lys 
    50                  55                  60                  


Pro Gly Val Asn Lys Ala Glu Val Thr Ile Thr Gln Gly Thr Tyr Lys 
65                  70                  75                  80  


Gly Arg Ile Glu Ile Ile Asp Gln Lys Tyr Asp Leu Val Ile Arg Asp 
                85                  90                  95      


Leu Arg Met Glu Asp Ala Gly Thr Tyr Lys Ala Asp Ile Asn Glu Glu 
            100                 105                 110         


Asn Glu Glu Thr Ile Thr Lys Ile Tyr Tyr Leu His Ile Tyr Arg Arg 
        115                 120                 125             


Leu Lys Thr Pro Lys Ile Thr Gln Ser Leu Ile Ser Ser Leu Asn Asn 
    130                 135                 140                 


Thr Cys Asn Ile Thr Leu Thr Cys Ser Val Glu Lys Glu Glu Lys Asp 
145                 150                 155                 160 


Val Thr Tyr Ser Trp Ser Pro Phe Gly Glu Lys Ser Asn Val Leu Gln 
                165                 170                 175     


Ile Val His Ser Pro Met Asp Gln Lys Leu Thr Tyr Thr Cys Thr Ala 
            180                 185                 190         


Gln Asn Pro Val Ser Asn Ser Ser Asp Ser Val Thr Val Gln Gln Pro 
        195                 200                 205             


Cys Thr Asp Thr Pro Ser Phe His Pro Arg His Ala Val Leu Pro Gly 
    210                 215                 220                 


Gly Leu Ala Val Leu Phe Leu Leu Ile Leu Ile Pro Met Leu Ala Phe 
225                 230                 235                 240 


Leu Phe Arg Leu Tyr Lys Arg Arg Arg Asp Arg Ile Val Leu Glu Ala 
                245                 250                 255     


Asp Asp Val Ser Lys Lys Thr Val Tyr Ala Val Val Ser Arg Asn Ala 
            260                 265                 270         


Gln Pro Thr Glu Ser Arg Ile Tyr Asp Glu Ile Pro Gln Ser Lys Met 
        275                 280                 285             


Leu Ser Cys Lys Lys Asp Pro Val Thr Thr Ile Tyr Ser Ser Val Gln 
    290                 295                 300                 


Leu Ser Glu Lys Met Lys Glu Thr Asn Met Lys Asp Arg Ser Leu Pro 
305                 310                 315                 320 


Lys Ala Leu Gly Asn Glu Ile Val Val 
                325                 


<210> 214
<211> 3520
<212> DNA
<213> Mus musculus

<400> 214
agtgcttgga gttcctctgt gactgaccac ttcttccttt tctgtctaat ggtgaacacc       60

tttctggacc agctctggac cagaatctga tttatgctct gctccggaaa caccacactg      120

aagtgaaagc agctaccaca ccagttattt ttcctcagaa gactggagtc tgactggaca      180

tggcccagcg ccatctgtgg atctggttcc tttgcctaca aacctggtct gaagcagcag      240

gaaaagatgc agacccggtg gtaatgaatg ggattcttgg ggagtcagtt actttcctct      300

taaatattca agaaccaaag aaaattgaca acattgcctg gacttctcaa tcatctgttg      360

cttttataaa accaggagtc aataaagctg aagttaccat aacccagggc acttataaag      420

gacgaataga aatcatagat cagaagtatg acctggtcat tagagacctg aggatggaag      480

atgcaggaac ttacaaagca gacatcaatg aagagaatga ggaaaccatc accaagatct      540

actaccttca tatctaccgt aagttatggc agcacggggc cttggattta cttttgattt      600

gaagatttat gatctaaacc acacccatat ttctgataac agagtttcct aactcttctt      660

atccttataa ttacataagc acatcagtac ttataaaggt ctaactttac ttctggcctt      720

gacagacttt agctgtaatc tgttttgcag cagaatttgt cctctgttct ttgttttcct      780

ttcctataaa atgtcaataa tcatattaat caatttgtaa gcattattat gacattctag      840

taagaaacta tatgcagagt ggtctttata aggcttctgc ttttaagata attacagaat      900

gcataggaaa atgcaaagaa ctatgaaagg atgtgttctg tgcccttctc ttgccctctc      960

ctctgttata ctagatccaa actcttagtc tcatcccccg tcttatacag accttctggg     1020

gtagcctttc ttcattgtct ctcctgattc caaagagata aaataagcag atcctggcac     1080

acacctttga ttccagcact caggaggcaa agacagaagg atctctatga gttcaaggct     1140

agcttggtct tcagagaaag ttccagaaca gccaagacta acaaaaagaa accctttctc     1200

aaaccaacct cccatcccca tcctcacccc ccaaaaacta ctagaatgaa agaaaaaaaa     1260

ataccaagac acaaaatgaa cagtgtctga ggaactctta tttctgtaag tattaatact     1320

ttcagaaatg cagaacagtg ttcaaggtca aaaacagaaa attggaactt tcttggaatg     1380

tgccagcact tacttaggaa tggaatcact tatattccta tagaatttaa tcacatatat     1440

agcaccggac agcattaatc acatatatag caccggacat cataagcaag gtagtagtga     1500

agcaccatcc caacattttc ttgtctcagt tctgcagggc agagaactgt tagccctgac     1560

tccagctttt tctacctaac agttttgtgc aggtgacatc tcgtccctgc tgagaaaatg     1620

aaatgagatt tagttttcac cactatggct gtaccaatac ctaccccaac gggtggcaca     1680

cacacacaca cacacacaca cacacacaca cacacacaca cacacacgtc tctccgaaaa     1740

taggtaaata atgatacttt tcttgtgttt cggctatttt ggaatattca gagcctactg     1800

ttgtagaata gctgggataa aatggagaca tcctgcccag gctgttattg actgtgcttt     1860

tttgttggca tctaggcatc tgggactggg atgattataa atctaggtga tgatgtttgg     1920

atttgtcttt gttgggtggg tggcttgttc cttgttttct gtttcctctc tggattttca     1980

gagagtgtgg tagctctatg ttttagtagg acattttctt tggatctgac atttatagcc     2040

actggaggtt ctcaataaaa gatgtttctg ggtattggga gctaacactt aggacctgtg     2100

ataggttagg agtatgaaag tgttcatagg agagagaaga agagtgttta gccaggatct     2160

gtttatttca tccccttgga atcagggaga cagtaaagtg aggtcaaccc acagggtctt     2220

ctctagatac tggggatgag actgggaagt tggatctaga ggaacagaag gaaacaggaa     2280

gatatacagg ctcctatctg cttctgggca ggaatgatct gggttagcag ggagtgcctg     2340

ctgaagatga gggctgggat aaaccaacaa gtggggagaa ggtgggtaga aagggaagat     2400

ctgtggaacc acaatagatg tgggattggg gatgtgcagg agtggggaca ttagaaggaa     2460

ggctgcagca ggtgttctgt tgcagagcta gggatgaagc tggagcttta gatttgtagg     2520

agaggaagcc ttctgttagc ttacatgttt cccaggcctg cttgggtggt gtgttcacaa     2580

ggaacactgg ttttggggac ttgtttactg gaatgaattg ggggaaggaa ggttggagta     2640

gaagatagag gtcctcaaag agaaaattaa taagtccaca aaatccaaac aaacagtgga     2700

aagaagtgaa taaactgtat aagacttgaa aatgaaaata aaatcaataa agaaaactaa     2760

aaccgagaga attctagaaa tgaaaatttt aagaatttga acagaaatta cagaggtaaa     2820

cttcaccaac aaaatatgag agatggaaga gagaatatta ggcattgaag atacaataga     2880

gaaaatgaat atatcagtca aagaaaatgt taaaccaaaa aaaaaaagtc ctaacaaaaa     2940

atacaaaaaa tttaggacac taagaaaaga caaaacctaa gactaataga aatataggaa     3000

ggaaaagaat tctacctcaa aggcccagaa aatatttcaa caaaatcata gaagaaaaat     3060

tttctcacct aaagaagata gatgcctata aggtatatga agcatatata acaacaaata     3120

gatttaacaa gaaaataaac tctccttggc acataacagt caaatcacaa agcatacaga     3180

acaaagaaag aatattaaaa gctacaaggg gaaaaggcca agtagtatat aaatgcagac     3240

ctagaatgat acctgatttc tcagtgaaga ctctaaaggc caatagagtc tggacaaatg     3300

tgctataaac tctaagagac cccagaggtc atccctgatt actataccca ccaaaatatc     3360

caacatccta aatggaaaaa ataggatatt ccataataaa gccaaattta aacaatatct     3420

gtctacaaat ccatctatag aagatgacag ggcggaaaat tccaaccaaa agagtttaac     3480

tataccaaat aaaaacaaaa ggaataaaca atctcaaagc                           3520


<210> 215
<211> 140
<212> PRT
<213> Mus musculus

<400> 215
Met Ala Gln Arg His Leu Trp Ile Trp Phe Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Ser Glu Ala Ala Gly Lys Asp Ala Asp Pro Val Val Met Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Leu Leu Asn Ile Gln Glu Pro Lys Lys 
        35                  40                  45              


Ile Asp Asn Ile Ala Trp Thr Ser Gln Ser Ser Val Ala Phe Ile Lys 
    50                  55                  60                  


Pro Gly Val Asn Lys Ala Glu Val Thr Ile Thr Gln Gly Thr Tyr Lys 
65                  70                  75                  80  


Gly Arg Ile Glu Ile Ile Asp Gln Lys Tyr Asp Leu Val Ile Arg Asp 
                85                  90                  95      


Leu Arg Met Glu Asp Ala Gly Thr Tyr Lys Ala Asp Ile Asn Glu Glu 
            100                 105                 110         


Asn Glu Glu Thr Ile Thr Lys Ile Tyr Tyr Leu His Ile Tyr Arg Lys 
        115                 120                 125             


Leu Trp Gln His Gly Ala Leu Asp Leu Leu Leu Ile 
    130                 135                 140 


<210> 216
<211> 3287
<212> DNA
<213> Mus musculus

<400> 216
agtgcttgga gttcctctgt gactgaccac ttcttccttt tctgtctaat ggtgaacacc       60

tttctggacc agctctggac cagaatctga tttatgctct gctccggaaa caccacactg      120

aagtgaaagc agctaccaca ccagttattt ttcctcagaa gactggagtc tgactggaca      180

tggcccagcg ccatctgtgg atctggttcc tttgcctaca aacctggtct gaagcagcag      240

gaaaagatgc agacccggtg gtaatgaatg ggattcttgg ggagtcagtt actttcctct      300

taaatattca agaaccaaag aaaattgaca acattgcctg gacttctcaa tcatctgttg      360

cttttataaa accaggagtc aataaagctg aagttaccat aacccagggc acttataaag      420

gacgaataga aatcatagat cagaagtatg acctggtcat tagagacctg aggatggaag      480

atgcaggaac ttacaaagca gacatcaatg aagagaatga ggaaaccatc accaagatct      540

actaccttca tatctaccgt cgacttaaaa caccaaaaat tacacagagt ttgatatcat      600

ctttgaacaa tacctgtaat atcacactga catgctctgt ggaaaaggaa gaaaaggatg      660

tcacatatag ctggagtccc tttggagaga aaagcaatgt ccttcaaatc gtccactccc      720

ccatggacca aaaactgacc tacacatgta cagcccagaa ccctgtcagc aacagttctg      780

actctgtcac tgtccagcag ccatgtacag acactccaag cttccatcct cgccatgctg      840

tgttgccagg aggattggcc gtgctctttc tgcttattct cattccgatg ttggcatttc      900

tgttccgttt gtataagaga aggcgagaca ggattgtcct ggaagatgat gtctcaaaga      960

aaacagtata tgctgtagtt tcaagaaatg ctcaacccac agagtccaga atctatgatg     1020

aaatccctca gtccaagatg ctgtcctgta agaaagatcc ggtgaccacc atttattcct     1080

cagtgcagct ttctgagaag atgaaggaaa ccaacatgaa ggacagaagt ctgcctaagg     1140

ctttgggtaa tgaaattgtt gtctaggtga ttctctaaga ccacgaagga cacaaggaca     1200

agtcatctat gaggattgaa tcaacggttt cagtcttttg gatataacct gggccagcca     1260

agggatttag gaatgaagca agctccgtgg gtagaggtct gatccccagt gtgtaatgtt     1320

aggggccatg tacaggattg actctcaggc ccacagatct ttacccagag aaaccctgac     1380

ctgctcccat gctgtttttc ctggggaaag gaccctaggg cactcaacct ttatgcaatc     1440

agacatgcct ctcagagact gtctaacagc ttccagacta atctctgtgc agtacttagt     1500

cttacaactc tcacgggcaa cggcttcaag ttccaatttt acgatgtgtc tagcctggga     1560

tgactgttta gtttctaatg tggcgagaat gtatgttacc atgtaggaag cacagactat     1620

ggcaatctat aaatgatttg tggcatgaga ctgatgtccg aatttagggg aaggggaatg     1680

gtcttactta ggcattttat ggaaattgag tctctctccc cgagaagagg gtgatgaagc     1740

agcatccacg tctgcctctt ctccagtaac ctgcttgtta tcgacaatgt ccagccgatg     1800

gtaatgaact gaaacaaatg cgcttgaaag agatgaatca atttgagatt taacaaatcg     1860

ggtcaatttc tgaaatgccc aaggaccgaa ggagatcaat aataggagtc ccaatagggg     1920

ccctaaaagg gagggcaaca aggttgaaag tcagggggag gttgaaaacc agttttggta     1980

gtctaccttc cccctaggcc attgtaaata cttgtgtatg ggtgtaactc agctatctat     2040

agttctaagt atccactctg gttcctcttt aggtcttaaa cttccttctt cctagttgat     2100

ggtaaattcc tgtgtaaggc agtggcctag cttttattca aagtgatagt gtaatgccag     2160

aggctattct gaatgtcact gaataggcaa cactctccct gaattctaag tccatggtct     2220

gttcaagggc tttttaggac attggaacac cagtgaaggc ttagctatgt cagaattcaa     2280

tcttaaaatg cacttataat aagataatat taaaagagag cacatggatc tatacaccag     2340

actaactcgg gaatagaata tgagtacaaa atgggcagta tgcagctgct gaactaaggc     2400

tgtggtagat accttttcaa agtttgcatt cccagatttt taaaccaagg atcgtttcct     2460

aactctaata ggcagcaaaa cgtaagcagg tctctaacaa aaacataaca gtagattcct     2520

tatctaaatt aggatctaca caattagtta attgacaaga attacaatga atataaaaag     2580

acttgccaag attggcgatc ttaactctta aaattatcta acaataagca tataggtaag     2640

gtacacaaac tttcatagct ataaggagct gacctgaaag gccaaaaaca gtgtctctga     2700

caaaagcatc ttgtacattc tctgtaccag tctttttgcc tcatgagtca gcttttttag     2760

ttgtttttat tttaagttgg caccaggttg gtactccttg ctgcagccca tggcggagat     2820

acgaagtttc tttatctgtt tgtaagtggc tgctctctga tttctcttct tttgtatact     2880

caacatagct ttctggtcac cactgtcagg gcactcacag gtcacaggtc agcctgtcac     2940

attggaagct agcatgctct tgtagcattc tgtggaaaaa acagaaacat tctccctttt     3000

ccccatatta agtatctgaa caggatcatg gcaagtgcca ataagtggat cctttttatc     3060

tgtcctagac atcattatat ctagtttgtt ttttttttgt aaataaaaat gtgattttat     3120

gtgcacaggg atataattcc taccttcttt gtttttaaag aaggtatagt ttttaaagtt     3180

ttacaatacc ttgtctttga gaattataaa atatctcagt aacatgtgta acattaaatt     3240

gttaacaaaa catctcttgg aggttttgaa aataaaaatt ttgaagc                   3287


<210> 217
<211> 328
<212> PRT
<213> Mus musculus

<400> 217
Met Ala Gln Arg His Leu Trp Ile Trp Phe Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Ser Glu Ala Ala Gly Lys Asp Ala Asp Pro Val Val Met Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Leu Leu Asn Ile Gln Glu Pro Lys Lys 
        35                  40                  45              


Ile Asp Asn Ile Ala Trp Thr Ser Gln Ser Ser Val Ala Phe Ile Lys 
    50                  55                  60                  


Pro Gly Val Asn Lys Ala Glu Val Thr Ile Thr Gln Gly Thr Tyr Lys 
65                  70                  75                  80  


Gly Arg Ile Glu Ile Ile Asp Gln Lys Tyr Asp Leu Val Ile Arg Asp 
                85                  90                  95      


Leu Arg Met Glu Asp Ala Gly Thr Tyr Lys Ala Asp Ile Asn Glu Glu 
            100                 105                 110         


Asn Glu Glu Thr Ile Thr Lys Ile Tyr Tyr Leu His Ile Tyr Arg Arg 
        115                 120                 125             


Leu Lys Thr Pro Lys Ile Thr Gln Ser Leu Ile Ser Ser Leu Asn Asn 
    130                 135                 140                 


Thr Cys Asn Ile Thr Leu Thr Cys Ser Val Glu Lys Glu Glu Lys Asp 
145                 150                 155                 160 


Val Thr Tyr Ser Trp Ser Pro Phe Gly Glu Lys Ser Asn Val Leu Gln 
                165                 170                 175     


Ile Val His Ser Pro Met Asp Gln Lys Leu Thr Tyr Thr Cys Thr Ala 
            180                 185                 190         


Gln Asn Pro Val Ser Asn Ser Ser Asp Ser Val Thr Val Gln Gln Pro 
        195                 200                 205             


Cys Thr Asp Thr Pro Ser Phe His Pro Arg His Ala Val Leu Pro Gly 
    210                 215                 220                 


Gly Leu Ala Val Leu Phe Leu Leu Ile Leu Ile Pro Met Leu Ala Phe 
225                 230                 235                 240 


Leu Phe Arg Leu Tyr Lys Arg Arg Arg Asp Arg Ile Val Leu Glu Asp 
                245                 250                 255     


Asp Val Ser Lys Lys Thr Val Tyr Ala Val Val Ser Arg Asn Ala Gln 
            260                 265                 270         


Pro Thr Glu Ser Arg Ile Tyr Asp Glu Ile Pro Gln Ser Lys Met Leu 
        275                 280                 285             


Ser Cys Lys Lys Asp Pro Val Thr Thr Ile Tyr Ser Ser Val Gln Leu 
    290                 295                 300                 


Ser Glu Lys Met Lys Glu Thr Asn Met Lys Asp Arg Ser Leu Pro Lys 
305                 310                 315                 320 


Ala Leu Gly Asn Glu Ile Val Val 
                325             


<210> 218
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 218
acaaguaaac ugcugacgat t                                                 21


<210> 219
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 219
guaaacugcu gacgaugcat t                                                 21


<210> 220
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 220
ucgcauggcu ggauuuacct t                                                 21


<210> 221
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 221
guuccgggaa ggggccaaut t                                                 21


<210> 222
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 222
gggccaauac agaccaggat t                                                 21


<210> 223
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 223
ccagaagaag ugaugcgggt t                                                 21


<210> 224
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 224
ucaccggcuc ucugugaaut t                                                 21


<210> 225
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 225
gaccacgaac aagaccguct t                                                 21


<210> 226
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 226
gaacaagacc guccaucuct t                                                 21


<210> 227
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 227
agaccgucca ucucaacgut t                                                 21


<210> 228
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 228
ccguccaucu caacguguct t                                                 21


<210> 229
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 229
ggagacggca caguauccat t                                                 21


<210> 230
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 230
caguauccac agucuugggt t                                                 21


<210> 231
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 231
guauccacag ucuugggaat t                                                 21


<210> 232
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 232
cucagcaggu cuaccugaat t                                                 21


<210> 233
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 233
gcgugggaga uacgggcaut t                                                 21


<210> 234
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 234
ugggagauac gggcauagat t                                                 21


<210> 235
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 235
ggagauacgg gcauagaggt t                                                 21


<210> 236
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 236
gauacgggca uagaggaugt t                                                 21


<210> 237
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 237
acgggcauag aggaugcaat t                                                 21


<210> 238
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 238
ggagcugucg ggaagaucat t                                                 21


<210> 239
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 239
gcgcgaccuu aucuccaact t                                                 21


<210> 240
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 240
gcgaccuuau cuccaacaat t                                                 21


<210> 241
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 241
cuggacaaac ugacagucat t                                                 21


<210> 242
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 242
ggaacuggag gacccgucut t                                                 21


<210> 243
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 243
gcagaggcgg ucuucaacat t                                                 21


<210> 244
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 244
uguaccucau cccaugagat t                                                 21


<210> 245
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 245
gacaaaccaa gucggaacat t                                                 21


<210> 246
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 246
aaaccaaguc ggaacagcat t                                                 21


<210> 247
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 247
agcuagacag auccccguut t                                                 21


<210> 248
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 248
cuaggcucau ggacgagaut t                                                 21


<210> 249
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 249
gagaagggau aacccuacat t                                                 21


<210> 250
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 250
ccaauguuuu ccacccauat t                                                 21


<210> 251
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 251
guuuuccacc cauaauccut t                                                 21


<210> 252
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 252
ccauaauccu uucugccgat t                                                 21


<210> 253
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 253
ccaagcuugu uaucagcuut t                                                 21


<210> 254
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 254
ggccaugguu cacauuagat t                                                 21


<210> 255
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 255
ccggauaucu guguuaccat t                                                 21


<210> 256
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 256
gcaugaguag cuugaaacut t                                                 21


<210> 257
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 257
gcaugggcuc uaucaaggat t                                                 21


<210> 258
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 258
acuaauaucu gagcaucuut t                                                 21


<210> 259
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 259
ggauuuaaug gcccaacaut t                                                 21


<210> 260
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 260
agggcaagau cucauuucat t                                                 21


<210> 261
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 261
uuuauuagag ggccuuauut t                                                 21


<210> 262
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 262
auugaugugu ucuaagucut t                                                 21


<210> 263
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 263
gggcagauga agccgagaat t                                                 21


<210> 264
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 264
ccaccgaaua ugaguaccut t                                                 21


<210> 265
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 265
ccgaauauga guaccuagat t                                                 21


<210> 266
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 266
gcacagacca cucaacccat t                                                 21


<210> 267
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 267
accaaaagag gucuguucat t                                                 21


<210> 268
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 268
aagcagacgg gcaaguggat t                                                 21


<210> 269
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 269
aguacugaag agugacggat t                                                 21


<210> 270
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 270
acugaagagu gacggacuut t                                                 21


<210> 271
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 271
ccaagggcag accuuucuut t                                                 21


<210> 272
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 272
aaggcuacac ccaagucuut t                                                 21


<210> 273
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 273
cuuucuacgu gacucuucut t                                                 21


<210> 274
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 274
gcaaccaagu cgugagagat t                                                 21


<210> 275
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 275
cgugagagau aagauuacut t                                                 21


<210> 276
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 276
aacaagagca ugucuacgat t                                                 21


<210> 277
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 277
cacuaggacu uggucaucat t                                                 21


<210> 278
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 278
acuaggacuu ggucaucaut t                                                 21


<210> 279
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 279
gucaucaugc cuacagacat t                                                 21


<210> 280
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 280
ggccagacag cuuuuaauut t                                                 21


<210> 281
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 281
gccagaggaa cgccagcgat t                                                 21


<210> 282
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 282
gccgucgcuu uuccagcaut t                                                 21


<210> 283
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 283
ggaacggccu gcgagagcut t                                                 21


<210> 284
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 284
ccgacuauga gaacauguut t                                                 21


<210> 285
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 285
gccuaagaug uccuaaccut t                                                 21


<210> 286
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 286
caauaaaugc uucgaggcut t                                                 21


<210> 287
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 287
cuucgaggcu gaugaggcut t                                                 21


<210> 288
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 288
cuuaauggaa auggcgauat t                                                 21


<210> 289
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 289
uaauggaaau ggcgauauut t                                                 21


<210> 290
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 290
uaucaugucc cugaaacgat t                                                 21


<210> 291
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 291
gaaacgaaug cuggagaaat t                                                 21


<210> 292
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 292
agacucaccu agagcuaaat t                                                 21


<210> 293
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 293
cucaccuaga gcuaaagaat t                                                 21


<210> 294
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 294
ucaccuagag cuaaagaaat t                                                 21


<210> 295
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 295
accuagagcu aaagaaauut t                                                 21


<210> 296
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 296
ccuagagcua aagaaauuat t                                                 21


<210> 297
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 297
ccggggagac guucagcuat t                                                 21


<210> 298
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 298
accaaaaauu acacagagut t                                                 21


<210> 299
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 299
gaggguaaug uccuucaaat t                                                 21


<210> 300
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 300
gguaaugucc uucaaaucut t                                                 21


<210> 301
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 301
ucauaugauc auuuaaggat t                                                 21


<210> 302
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 302
gaacacaguu uauuccgaat t                                                 21


<210> 303
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 303
ggaacugggu auaauccaat t                                                 21


<210> 304
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 304
gcaccaacua ccauuagcat t                                                 21


<210> 305
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 305
cacuacaguu aacgcugaat t                                                 21


<210> 306
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 306
gguaucagga aucaaaauut t                                                 21


<210> 307
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 307
ccuuacagca uaacuaauut t                                                 21


<210> 308
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 308
gaggccguca ccauaaagut t                                                 21


<210> 309
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 309
gaagcgagag cuaaacagat t                                                 21


<210> 310
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 310
gugcucggcg uauuuuucat t                                                 21


<210> 311
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 311
agaacuauac cauaagagat t                                                 21


<210> 312
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 312
ccauaagaga cauguggaat t                                                 21


<210> 313
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 313
ggccauagaa acguuuuaat t                                                 21


<210> 314
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 314
ccauagaaac guuuuaauut t                                                 21


<210> 315
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 315
acauauauca ucaggucuut t                                                 21


<210> 316
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 316
cgacgcacgc cucuucuuut t                                                 21


<210> 317
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 317
ggcugcgcuu caaguacuat t                                                 21


<210> 318
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 318
guucccgaug uuaacgucut t                                                 21


<210> 319
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 319
ccagcugccg aauuguacat t                                                 21


<210> 320
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 320
gcugccgaau uguacacgat t                                                 21


<210> 321
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 321
guagcuacag gaugaugaat t                                                 21


<210> 322
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 322
cucuggaauu gcuacugcut t                                                 21


<210> 323
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 323
cuaaccuggu uuuauacuut t                                                 21


<210> 324
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 324
cuuucgacca gaagauugut t                                                 21


<210> 325
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 325
uccagaaaau cuaaguacut t                                                 21


<210> 326
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 326
gaauccaaau uuaaaggcat t                                                 21


<210> 327
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 327
cccaagccug ucaucaaaat t                                                 21


<210> 328
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 328
acaacuguua ucugaaacut t                                                 21


<210> 329
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 329
ccuggcgagu cuguaaacut t                                                 21


<210> 330
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 330
cuggcgaguc uguaaacuat t                                                 21


<210> 331
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 331
uguuauacuu gccaagucat t                                                 21


<210> 332
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 332
ccggccacuc caaaaaccut t                                                 21


<210> 333
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 333
ggccccagga cuacucacut t                                                 21


<210> 334
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 334
acuccucggu gcucauaaut t                                                 21


<210> 335
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 335
caacgucacc uauguuccat t                                                 21


<210> 336
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 336
ucaccuaugu uccacagaat t                                                 21


<210> 337
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 337
cccaacaacu gguaucuuut t                                                 21


<210> 338
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 338
ccagagcagg agugguucat t                                                 21


<210> 339
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 339
gguucauggg gccauuggat t                                                 21


<210> 340
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 340
cugaucauuu cgccuaaaat t                                                 21


<210> 341
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 341
cauuucgccu aaaagagcat t                                                 21


<210> 342
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 342
gccuaaaaga gcaaggacut t                                                 21


<210> 343
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 343
ggaacuccac uaugcaucut t                                                 21


<210> 344
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 344
caaggaggau ccaagagcut t                                                 21


<210> 345
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 345
ggauccaaga gcugacuaut t                                                 21


<210> 346
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 346
ucucgagccu ccguucaaat t                                                 21


<210> 347
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 347
cuccguucaa auugaucaut t                                                 21


<210> 348
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 348
ugaucaucau caaaacuuat t                                                 21


<210> 349
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 349
accuuugaau agggaauuut t                                                 21


<210> 350
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 350
ggaccaggcc gugaucucut t                                                 21


<210> 351
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 351
ggucaggugg agaucucuut t                                                 21


<210> 352
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 352
uuuaauguau cgcuaccaat t                                                 21


<210> 353
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 353
aaaucgacac cugaaaaagt t                                                 21


<210> 354
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 354
cguugcgcug gaaggaauut t                                                 21


<210> 355
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 355
cugcgcgagg cgcaauacat t                                                 21


<210> 356
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 356
cccucgaugu acauagcuut t                                                 21


<210> 357
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 357
cacagugcau aagcaguuut t                                                 21


<210> 358
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 358
aaaucaauca uguuacacut t                                                 21


<210> 359
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 359
gcacauagca agcugaacut t                                                 21


<210> 360
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 360
gcuugcggga cgucguagat t                                                 21


<210> 361
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 361
gacgucguag agaaaaccat t                                                 21


<210> 362
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 362
cgaccaacga cuccacaaut t                                                 21


<210> 363
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 363
ccaacgacuc cacaauccut t                                                 21


<210> 364
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 364
ccacaauccu agauaaggut t                                                 21


<210> 365
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 365
ggcugcacaa caaccuuaut t                                                 21


<210> 366
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 366
guucaugacg cucucgauat t                                                 21


<210> 367
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 367
cggcucgcuc gauaccguut t                                                 21


<210> 368
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 368
accacccaca agauuauuut t                                                 21


<210> 369
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 369
ggaucuauac caacgccaat t                                                 21


<210> 370
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 370
cgccaaacgc acgaguauut t                                                 21


<210> 371
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 371
gcuucgccga gaacaacuut t                                                 21


<210> 372
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 372
gcgacaugaa ggacagcaut t                                                 21


<210> 373
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 373
cccgcuggcc auagcauuat t                                                 21


<210> 374
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 374
gucucaaguc cguauguaat t                                                 21


<210> 375
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 375
ucucaagucc guauguaaat t                                                 21


<210> 376
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 376
ccguauguaa aucagaucut t                                                 21


<210> 377
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 377
acaaguaaag uuauucucat t                                                 21


<210> 378
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 378
aaaguuauuc ucaauccaut t                                                 21


<210> 379
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 379
gugagcacuc aggaugacut t                                                 21


<210> 380
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 380
gaaaacaccc acaguccgut t                                                 21


<210> 381
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 381
caguccgugc ugcauuaaut t                                                 21


<210> 382
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 382
guccgugcug cauuaaucut t                                                 21


<210> 383
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 383
ugcugaaagg ucguguggat t                                                 21


<210> 384
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 384
gcguucagau ccagauggut t                                                 21


<210> 385
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 385
aaauacaaag auccgggcat t                                                 21


<210> 386
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 386
auaugagcaa guugcucaat t                                                 21


<210> 387
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 387
uauucuacag gugguuucut t                                                 21


<210> 388
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 388
uauagugccg agcaguucut t                                                 21


<210> 389
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 389
cagcaucuug gauuacaca                                                    19


<210> 390
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 390
ggauacgacc agagcuuga                                                    19


<210> 391
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 391
gcgauauggc ugucaguaa                                                    19


<210> 392
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 392
cuaugguuau gacuugaaa                                                    19


<210> 393
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 393
gguuaugacu ugaacucua                                                    19


<210> 394
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 394
ggcacacccu ucaucucaa                                                    19


<210> 395
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 395
cccacuccgu cuaagauca                                                    19


<210> 396
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 396
ccacuccguc uaagaucaa                                                    19


<210> 397
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 397
cacuccgucu aagaucaaa                                                    19


<210> 398
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 398
gagacaauua caacagagat t                                                 21


<210> 399
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 399
cuuuggguca accaacacat t                                                 21


<210> 400
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 400
caaccaacac caauagccat t                                                 21


<210> 401
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 401
ccaucugccc guacuucuat t                                                 21


<210> 402
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 402
ccaccaaagu cauuugucut t                                                 21


<210> 403
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 403
gucaaaaauu caccuaggat t                                                 21


<210> 404
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 404
ggauuuaucu uagauacuat t                                                 21


<210> 405
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 405
cauacuaauu gguguacuut t                                                 21


<210> 406
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 406
agcuauaauc aucauuguat t                                                 21


<210> 407
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 407
cucccaacuc ugaucaagat t                                                 21


<210> 408
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 408
ggauauacuc aauuacacut t                                                 21


<210> 409
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 409
ggucaagaua aaugcagaat t                                                 21


<210> 410
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 410
agguaggcua guauuauuut t                                                 21


<210> 411
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 411
ccccaagcuu gaauuuucat t                                                 21


<210> 412
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 412
ggguaagcca uaagcgaaut t                                                 21


<210> 413
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 413
ccauaagcga aucuuaauut t                                                 21


<210> 414
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 414
ugccauaucu cuaauagaat t                                                 21


<210> 415
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 415
gccuagaauc uuguauaaut t                                                 21


<210> 416
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 416
ccuagaaucu uguauaauat t                                                 21


<210> 417
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 417
gcucucauag gaaaguuuut t                                                 21


<210> 418
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 418
cugucagaag gguaucucat t                                                 21


<210> 419
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 419
cuacgugagc ugcaaaucat t                                                 21


<210> 420
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 420
ggugauggcc auuaauucat t                                                 21


<210> 421
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 421
cauuauggac accguguuut t                                                 21


<210> 422
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 422
gucugaacuc aucaugacat t                                                 21


<210> 423
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 423
gcaauugaug ucaacugaat t                                                 21


<210> 424
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 424
caauguaaau ccauagagat t                                                 21


<210> 425
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 425
guaagaggag ccauaaggat t                                                 21


<210> 426
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 426
gccgacagcg uucuguuuut t                                                 21


<210> 427
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 427
cugcaagcgu uucuucgaat t                                                 21


<210> 428
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 428
gcccggauuu ugcccaauat t                                                 21


<210> 429
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 429
ggauuuugcc caauaagaat t                                                 21


<210> 430
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 430
caauaagaac cgagacgaat t                                                 21


<210> 431
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 431
gaaccgagac gaacugaaut t                                                 21


<210> 432
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 432
agacgaacug aauggcuuut t                                                 21


<210> 433
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 433
ccaugggcgu gcaagacuut t                                                 21


<210> 434
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 434
gcgugcaaga cuuugacaut t                                                 21


<210> 435
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 435
agaguaaccg gaaggauua                                                    19


<210> 436
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 436
gaguaaccgg aaggauuaa                                                    19


<210> 437
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 437
guaaccggaa ggauuacua                                                    19


<210> 438
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 438
cggaaggauu acucgcuga                                                    19


<210> 439
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 439
ggaaggauua cucgcugaa                                                    19


<210> 440
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 440
ggauuacucg cugacgaua                                                    19


<210> 441
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 441
ccgugcaaga gggcaugua                                                    19


<210> 442
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 442
cgggcaggga augauauaa                                                    19


<210> 443
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 443
gcagggaaug auauaagca                                                    19


<210> 444
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 444
ggaaugauau aagcuggaa                                                    19


<210> 445
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 445
ggaacaagau ggauuaucat t                                                 21


<210> 446
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 446
ccauacaguc aguaucaaut t                                                 21


<210> 447
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 447
cauuaaagau agucaucuut t                                                 21


<210> 448
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 448
agguaugguu aauaaguuut t                                                 21


<210> 449
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 449
gauccugguu gguguugcat t                                                 21


<210> 450
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 450
guaugagguc uaggaacaut t                                                 21


<210> 451
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 451
caucaaacuc uuaguuacut t                                                 21


<210> 452
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 452
cuccguauuu cagacugaat t                                                 21


<210> 453
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 453
gcacauacuu gagacuguut t                                                 21


<210> 454
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 454
gcaacgaagg gaaaugucut t                                                 21


<210> 455
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 455
cacggcgugg ccauauacat t                                                 21


<210> 456
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 456
ggggauaccu cauaaagcat t                                                 21


<210> 457
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 457
caagcaaacg gucauaagut t                                                 21


<210> 458
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 458
uuguguacua ucaagucaat t                                                 21


<210> 459
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 459
ccaucugcga uucauguuut t                                                 21


<210> 460
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 460
cucuacacga uggauuccat t                                                 21


<210> 461
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 461
cucauugcag accggaaaut t                                                 21


<210> 462
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 462
accggaaauu ucagcauuut t                                                 21


<210> 463
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 463
ggucgaggac auuauuuuct t                                                 21


<210> 464
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 464
cuuacgcuga guacuucgat t                                                 21


<210> 465
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 465
ucgucagcag uuuacuugut t                                                 21


<210> 466
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 466
ugcaucguca gcaguuuact t                                                 21


<210> 467
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 467
gguaaaucca gccaugcgat t                                                 21


<210> 468
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 468
auuggccccu ucccggaact t                                                 21


<210> 469
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 469
uccuggucug uauuggccct t                                                 21


<210> 470
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 470
cccgcaucac uucuucuggt t                                                 21


<210> 471
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 471
auucacagag agccggugat t                                                 21


<210> 472
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 472
gacggucuug uucgugguct t                                                 21


<210> 473
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 473
gagauggacg gucuuguuct t                                                 21


<210> 474
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 474
acguugagau ggacggucut t                                                 21


<210> 475
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 475
gacacguuga gauggacggt t                                                 21


<210> 476
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 476
uggauacugu gccgucucct t                                                 21


<210> 477
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 477
cccaagacug uggauacugt t                                                 21


<210> 478
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 478
uucccaagac uguggauact t                                                 21


<210> 479
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 479
uucagguaga ccugcugagt t                                                 21


<210> 480
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 480
augcccguau cucccacgct t                                                 21


<210> 481
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 481
ucuaugcccg uaucucccat t                                                 21


<210> 482
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 482
ccucuaugcc cguaucucct t                                                 21


<210> 483
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 483
cauccucuau gcccguauct t                                                 21


<210> 484
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 484
uugcauccuc uaugcccgut t                                                 21


<210> 485
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 485
ugaucuuccc gacagcucct t                                                 21


<210> 486
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 486
guuggagaua aggucgcgct t                                                 21


<210> 487
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 487
uuguuggaga uaaggucgct t                                                 21


<210> 488
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 488
ugacugucag uuuguccagt t                                                 21


<210> 489
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 489
agacgggucc uccaguucct t                                                 21


<210> 490
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 490
uguugaagac cgccucugct t                                                 21


<210> 491
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 491
ucucauggga ugagguacat t                                                 21


<210> 492
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 492
uguuccgacu ugguuuguct t                                                 21


<210> 493
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 493
ugcuguuccg acuugguuut t                                                 21


<210> 494
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 494
aacggggauc ugucuagcut t                                                 21


<210> 495
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 495
aucucgucca ugagccuagt t                                                 21


<210> 496
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 496
uguaggguua ucccuucuct t                                                 21


<210> 497
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 497
uaugggugga aaacauuggt t                                                 21


<210> 498
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 498
aggauuaugg guggaaaact t                                                 21


<210> 499
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 499
ucggcagaaa ggauuauggt t                                                 21


<210> 500
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 500
aagcugauaa caagcuuggt t                                                 21


<210> 501
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 501
ucuaauguga accauggcct t                                                 21


<210> 502
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 502
ugguaacaca gauauccggt t                                                 21


<210> 503
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 503
aguuucaagc uacucaugct t                                                 21


<210> 504
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 504
uccuugauag agcccaugct t                                                 21


<210> 505
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 505
aagaugcuca gauauuagut t                                                 21


<210> 506
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 506
auguugggcc auuaaaucct t                                                 21


<210> 507
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 507
ugaaaugaga ucuugcccut t                                                 21


<210> 508
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 508
aauaaggccc ucuaauaaat t                                                 21


<210> 509
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 509
agacuuagaa cacaucaaut t                                                 21


<210> 510
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 510
uucucggcuu caucugccct t                                                 21


<210> 511
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 511
agguacucau auucgguggt t                                                 21


<210> 512
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 512
ucuagguacu cauauucggt t                                                 21


<210> 513
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 513
uggguugagu ggucugugct t                                                 21


<210> 514
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 514
ugaacagacc ucuuuuggut t                                                 21


<210> 515
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 515
uccacuugcc cgucugcuut t                                                 21


<210> 516
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 516
uccgucacuc uucaguacut t                                                 21


<210> 517
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 517
aaguccguca cucuucagut t                                                 21


<210> 518
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 518
aagaaagguc ugcccuuggt t                                                 21


<210> 519
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 519
aagacuuggg uguagccuut t                                                 21


<210> 520
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 520
agaagaguca cguagaaagt t                                                 21


<210> 521
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 521
ucucucacga cuugguugct t                                                 21


<210> 522
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 522
aguaaucuua ucucucacgt t                                                 21


<210> 523
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 523
ucguagacau gcucuuguut t                                                 21


<210> 524
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 524
ugaugaccaa guccuagugt t                                                 21


<210> 525
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 525
augaugacca aguccuagut t                                                 21


<210> 526
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 526
ugucuguagg caugaugact t                                                 21


<210> 527
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 527
aauuaaaagc ugucuggcct t                                                 21


<210> 528
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 528
ucgcuggcgu uccucuggct t                                                 21


<210> 529
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 529
augcuggaaa agcgacggct t                                                 21


<210> 530
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 530
agcucucgca ggccguucct t                                                 21


<210> 531
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 531
aacauguucu cauagucggt t                                                 21


<210> 532
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 532
agguuaggac aucuuaggct t                                                 21


<210> 533
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 533
agccucgaag cauuuauugt t                                                 21


<210> 534
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 534
agccucauca gccucgaagt t                                                 21


<210> 535
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 535
uaucgccauu uccauuaagt t                                                 21


<210> 536
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 536
aauaucgcca uuuccauuat t                                                 21


<210> 537
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 537
ucguuucagg gacaugauat t                                                 21


<210> 538
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 538
uuucuccagc auucguuuct t                                                 21


<210> 539
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 539
uuuagcucua ggugagucut t                                                 21


<210> 540
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 540
uucuuuagcu cuaggugagt t                                                 21


<210> 541
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 541
uuucuuuagc ucuaggugat t                                                 21


<210> 542
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 542
aauuucuuua gcucuaggut t                                                 21


<210> 543
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 543
uaauuucuuu agcucuaggt t                                                 21


<210> 544
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 544
uagcugaacg ucuccccggt t                                                 21


<210> 545
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 545
acucugugua auuuuuggut t                                                 21


<210> 546
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 546
uuugaaggac auuacccuct t                                                 21


<210> 547
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 547
agauuugaag gacauuacct t                                                 21


<210> 548
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 548
uccuuaaaug aucauaugat t                                                 21


<210> 549
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 549
uucggaauaa acuguguuct t                                                 21


<210> 550
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 550
uuggauuaua cccaguucct t                                                 21


<210> 551
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 551
ugcuaauggu aguuggugct t                                                 21


<210> 552
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 552
uucagcguua acuguagugt t                                                 21


<210> 553
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 553
aauuuugauu ccugauacct t                                                 21


<210> 554
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 554
aauuaguuau gcuguaaggt t                                                 21


<210> 555
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 555
acuuuauggu gacggccuct t                                                 21


<210> 556
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 556
ucuguuuagc ucucgcuuct t                                                 21


<210> 557
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 557
ugaaaaauac gccgagcact t                                                 21


<210> 558
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 558
ucucuuaugg uauaguucut t                                                 21


<210> 559
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 559
uuccacaugu cucuuauggt t                                                 21


<210> 560
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 560
uuaaaacguu ucuauggcct t                                                 21


<210> 561
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 561
aauuaaaacg uuucuauggt t                                                 21


<210> 562
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 562
aagaccugau gauauaugut t                                                 21


<210> 563
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 563
aaagaagagg cgugcgucgt t                                                 21


<210> 564
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 564
uaguacuuga agcgcagcct t                                                 21


<210> 565
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 565
agacguuaac aucgggaact t                                                 21


<210> 566
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 566
uguacaauuc ggcagcuggt t                                                 21


<210> 567
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 567
ucguguacaa uucggcagct t                                                 21


<210> 568
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 568
uucaucaucc uguagcuact t                                                 21


<210> 569
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 569
agcaguagca auuccagagt t                                                 21


<210> 570
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 570
aaguauaaaa ccagguuagt t                                                 21


<210> 571
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 571
acaaucuucu ggucgaaagt t                                                 21


<210> 572
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 572
aguacuuaga uuuucuggat t                                                 21


<210> 573
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 573
ugccuuuaaa uuuggauuct t                                                 21


<210> 574
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 574
uuuugaugac aggcuugggt t                                                 21


<210> 575
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 575
aguuucagau aacaguugut t                                                 21


<210> 576
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 576
aguuuacaga cucgccaggt t                                                 21


<210> 577
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 577
uaguuuacag acucgccagt t                                                 21


<210> 578
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 578
ugacuuggca aguauaacat t                                                 21


<210> 579
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 579
agguuuuugg aguggccggt t                                                 21


<210> 580
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 580
agugaguagu ccuggggcct t                                                 21


<210> 581
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 581
auuaugagca ccgaggagut t                                                 21


<210> 582
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 582
uggaacauag gugacguugt t                                                 21


<210> 583
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 583
uucuguggaa cauaggugat t                                                 21


<210> 584
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 584
aaagauacca guuguugggt t                                                 21


<210> 585
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 585
ugaaccacuc cugcucuggt t                                                 21


<210> 586
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 586
uccaauggcc ccaugaacct t                                                 21


<210> 587
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 587
uuuuaggcga aaugaucagt t                                                 21


<210> 588
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 588
ugcucuuuua ggcgaaaugt t                                                 21


<210> 589
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 589
aguccuugcu cuuuuaggct t                                                 21


<210> 590
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 590
agaugcauag uggaguucct t                                                 21


<210> 591
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 591
agcucuugga uccuccuugt t                                                 21


<210> 592
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 592
auagucagcu cuuggaucct t                                                 21


<210> 593
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 593
uuugaacgga ggcucgagat t                                                 21


<210> 594
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 594
augaucaauu ugaacggagt t                                                 21


<210> 595
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 595
uaaguuuuga ugaugaucat t                                                 21


<210> 596
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 596
aaauucccua uucaaaggut t                                                 21


<210> 597
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 597
agagaucacg gccuggucct t                                                 21


<210> 598
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 598
aagagaucuc caccugacct t                                                 21


<210> 599
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 599
uugguagcga uacauuaaat t                                                 21


<210> 600
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 600
cuuuuucagg ugucgauuut t                                                 21


<210> 601
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 601
aauuccuucc agcgcaacgt t                                                 21


<210> 602
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 602
uguauugcgc cucgcgcagt t                                                 21


<210> 603
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 603
aagcuaugua caucgagggt t                                                 21


<210> 604
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 604
aaacugcuua ugcacugugt t                                                 21


<210> 605
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 605
aguguaacau gauugauuut t                                                 21


<210> 606
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 606
aguucagcuu gcuaugugct t                                                 21


<210> 607
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 607
ucuacgacgu cccgcaagct t                                                 21


<210> 608
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 608
ugguuuucuc uacgacguct t                                                 21


<210> 609
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 609
auuguggagu cguuggucgt t                                                 21


<210> 610
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 610
aggauugugg agucguuggt t                                                 21


<210> 611
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 611
accuuaucua ggauuguggt t                                                 21


<210> 612
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 612
auaagguugu ugugcagcct t                                                 21


<210> 613
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 613
uaucgagagc gucaugaact t                                                 21


<210> 614
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 614
aacgguaucg agcgagccgt t                                                 21


<210> 615
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 615
aaauaaucuu guggguggut t                                                 21


<210> 616
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 616
uuggcguugg uauagaucct t                                                 21


<210> 617
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 617
aauacucgug cguuuggcgt t                                                 21


<210> 618
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 618
aaguuguucu cggcgaagct t                                                 21


<210> 619
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 619
augcuguccu ucaugucgct t                                                 21


<210> 620
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 620
uaaugcuaug gccagcgggt t                                                 21


<210> 621
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 621
uuacauacgg acuugagact t                                                 21


<210> 622
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 622
uuuacauacg gacuugagat t                                                 21


<210> 623
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 623
agaucugauu uacauacggt t                                                 21


<210> 624
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 624
ugagaauaac uuuacuugut t                                                 21


<210> 625
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 625
auggauugag aauaacuuut t                                                 21


<210> 626
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 626
agucauccug agugcucact t                                                 21


<210> 627
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 627
acggacugug gguguuuuct t                                                 21


<210> 628
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 628
auuaaugcag cacggacugt t                                                 21


<210> 629
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 629
agauuaaugc agcacggact t                                                 21


<210> 630
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 630
uccacacgac cuuucagcat t                                                 21


<210> 631
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 631
accaucugga ucugaacgct t                                                 21


<210> 632
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 632
ugcccggauc uuuguauuut t                                                 21


<210> 633
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 633
uugagcaacu ugcucauaut t                                                 21


<210> 634
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 634
agaaaccacc uguagaauat t                                                 21


<210> 635
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 635
agaacugcuc ggcacuauat t                                                 21


<210> 636
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 636
tguguaaucc aagaugcugu u                                                 21


<210> 637
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 637
tcaagcucug gucguauccu u                                                 21


<210> 638
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 638
tuacugacag ccauaucgcu u                                                 21


<210> 639
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 639
tuucaaguca uaaccauagu u                                                 21


<210> 640
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 640
tagaguucaa gucauaaccu u                                                 21


<210> 641
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 641
tugagaugaa gggugugccu u                                                 21


<210> 642
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 642
tgaucuuaga cggagugggu u                                                 21


<210> 643
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 643
tugaucuuag acggaguggu u                                                 21


<210> 644
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 644
tuugaucuua gacggagugu u                                                 21


<210> 645
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 645
ucucuguugu aauugucuct t                                                 21


<210> 646
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 646
uguguugguu gacccaaagt t                                                 21


<210> 647
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 647
uggcuauugg uguugguugt t                                                 21


<210> 648
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 648
uagaaguacg ggcagauggt t                                                 21


<210> 649
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 649
agacaaauga cuuugguggt t                                                 21


<210> 650
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 650
uccuagguga auuuuugact t                                                 21


<210> 651
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 651
uaguaucuaa gauaaaucct t                                                 21


<210> 652
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 652
aaguacacca auuaguaugt t                                                 21


<210> 653
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 653
uacaaugaug auuauagcut t                                                 21


<210> 654
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 654
ucuugaucag aguugggagt t                                                 21


<210> 655
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 655
aguguaauug aguauaucct t                                                 21


<210> 656
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 656
uucugcauuu aucuugacct t                                                 21


<210> 657
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 657
aaauaauacu agccuaccut t                                                 21


<210> 658
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 658
ugaaaauuca agcuuggggt t                                                 21


<210> 659
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 659
auucgcuuau ggcuuaccct t                                                 21


<210> 660
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 660
aauuaagauu cgcuuauggt t                                                 21


<210> 661
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 661
uucuauuaga gauauggcat t                                                 21


<210> 662
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 662
auuauacaag auucuaggct t                                                 21


<210> 663
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 663
uauuauacaa gauucuaggt t                                                 21


<210> 664
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 664
aaaacuuucc uaugagagct t                                                 21


<210> 665
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 665
ugagauaccc uucugacagt t                                                 21


<210> 666
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 666
ugauuugcag cucacguagt t                                                 21


<210> 667
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 667
ugaauuaaug gccaucacct t                                                 21


<210> 668
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 668
aaacacggug uccauaaugt t                                                 21


<210> 669
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 669
ugucaugaug aguucagact t                                                 21


<210> 670
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 670
uucaguugac aucaauugct t                                                 21


<210> 671
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 671
ucucuaugga uuuacauugt t                                                 21


<210> 672
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 672
uccuuauggc uccucuuact t                                                 21


<210> 673
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 673
aaaacagaac gcugucggct t                                                 21


<210> 674
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 674
uucgaagaaa cgcuugcagt t                                                 21


<210> 675
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 675
uauugggcaa aauccgggct t                                                 21


<210> 676
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 676
uucuuauugg gcaaaaucct t                                                 21


<210> 677
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 677
uucgucucgg uucuuauugt t                                                 21


<210> 678
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 678
auucaguucg ucucgguuct t                                                 21


<210> 679
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 679
aaagccauuc aguucgucut t                                                 21


<210> 680
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 680
aagucuugca cgcccauggt t                                                 21


<210> 681
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 681
augucaaagu cuugcacgct t                                                 21


<210> 682
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 682
taauccuucc gguuacucuu u                                                 21


<210> 683
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 683
tuaauccuuc cgguuacucu u                                                 21


<210> 684
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 684
taguaauccu uccgguuacu u                                                 21


<210> 685
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 685
tcagcgagua auccuuccgu u                                                 21


<210> 686
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 686
tucagcgagu aauccuuccu u                                                 21


<210> 687
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 687
taucgucagc gaguaauccu u                                                 21


<210> 688
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 688
tacaugcccu cuugcacggu u                                                 21


<210> 689
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 689
tuauaucauu cccugcccgu u                                                 21


<210> 690
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 690
tgcuuauauc auucccugcu u                                                 21


<210> 691
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 691
tuccagcuua uaucauuccu u                                                 21


<210> 692
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 692
ugauaaucca ucuuguucct t                                                 21


<210> 693
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 693
auugauacug acuguauggt t                                                 21


<210> 694
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 694
aagaugacua ucuuuaaugt t                                                 21


<210> 695
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 695
aaacuuauua accauaccut t                                                 21


<210> 696
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 696
ugcaacacca accaggauct t                                                 21


<210> 697
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 697
auguuccuag accucauact t                                                 21


<210> 698
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 698
aguaacuaag aguuugaugt t                                                 21


<210> 699
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 699
uucagucuga aauacggagt t                                                 21


<210> 700
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 700
aacagucuca aguaugugct t                                                 21


<210> 701
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 701
agacauuucc cuucguugct t                                                 21


<210> 702
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 702
uguauauggc cacgccgugt t                                                 21


<210> 703
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 703
ugcuuuauga gguaucccct t                                                 21


<210> 704
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 704
acuuaugacc guuugcuugt t                                                 21


<210> 705
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 705
uugacuugau aguacacaat t                                                 21


<210> 706
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 706
aaacaugaau cgcagauggt t                                                 21


<210> 707
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 707
uggaauccau cguguagagt t                                                 21


<210> 708
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 708
auuuccgguc ugcaaugagt t                                                 21


<210> 709
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 709
aaaugcugaa auuuccggut t                                                 21


<210> 710
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 710
gaaaauaaug uccucgacct t                                                 21


<210> 711
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 711
ucgaaguacu cagcguaagt t                                                 21


<210> 712
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 712
Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asn Pro Asn Thr Gly Gly Thr Ser Tyr Asn Pro Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Asn Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Ser Pro Tyr Tyr Arg Tyr Asp Asp Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210> 713
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 713
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Thr Val Asn Ser Thr 
            20                  25                  30          


Tyr Leu His Trp Phe Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Gly Ser Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys 
            100                 105             


<210> 714
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 714
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Thr Gln Ser Met 
65                  70                  75                  80  


Ile Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Gly Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Gly Ser Tyr Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210> 715
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 715
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 716
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 716
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Gly Gly Ser Ser Thr Ile Phe Tyr Ala Asn Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ala Ser Tyr Gly Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 717
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 717
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Val His Asn 
            20                  25                  30          


Asp Gly Asn Thr Tyr Phe Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser Tyr Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 718
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 718
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ile Ala Ala Trp His Trp Ile Arg Leu Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Arg Ser Lys Trp Asn Tyr Asp Tyr 
    50                  55                  60                  


Ala Leu Ser Val Lys Ser Arg Ile Asn Ile Asn Pro Asp Thr Ser Lys 
65                  70                  75                  80  


Asn Leu Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Thr Arg Gly Gly Gly Arg Ala His Ser Ala Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 719
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 719
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          


His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Phe Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Pro Gly 
                85                  90                  95      


Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 720
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 720
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile His Trp Val Gln Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Val Leu Arg Ile Arg Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


His Asp Arg Val Thr Ile Asp Ala Asp Thr Ser Thr Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Arg Gln Gly Val Ala Pro Thr Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210> 721
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 721
Gln Ala Val Leu Thr Gln Pro Ser Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Asn Leu Arg Ser Gly Ile Asp Val Gly Thr 
            20                  25                  30          


Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Thr Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210> 722
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 722
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Lys Arg Leu Thr Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 723
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 723
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 724
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 724
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Met Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Asn Tyr Glu Asp Phe Ala Met Asp Tyr Arg Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210> 725
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 725
Asp Ile Val Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 726
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 726
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Gly Gly Thr Arg His Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Asn Tyr Glu Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210> 727
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 727
Asp Ile Val Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Asp Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Phe 
        35                  40                  45              


Tyr Trp Thr Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Arg Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Arg Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 728
<211> 327
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 728
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210> 729
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 729
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210> 730
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 730
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


