                         SEQUENCE LISTING

<110>  INTREXON CORPORATION
 
<120>  IN VIVO CONTROLLED COMBINATION THERAPY FOR TREATMENT OF CANCER

<130>  2584.155PC03/PAJ/MKK

<150>  US 62/854,771
<151>  2019-05-30

<150>  US 62/834,685
<151>  2019-04-16

<150>  US 62/690,552
<151>  2018-06-27

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  648
<212>  DNA
<213>  Mus musculus

<400>  1
atgtgtcaat cacgctacct cctctttttg gccacccttg ccctcctaaa ccacctcagt       60

ttggccaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg      120

ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc      180

actgctgaag acatcgatca tgaagacatc acacgggacc aaaccagcac attgaagacc      240

tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc      300

acaacaagag ggagctgcct gcccccacag aagacgtctt tgatgatgac cctgtgcctt      360

ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca      420

cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgctggt ggccatcgat      480

gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga      540

gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc      600

cgcgtcgtga ccatcaacag ggtgatgggc tatctgagct ccgcctga                   648


<210>  2
<211>  1008
<212>  DNA
<213>  Mus musculus

<400>  2
atgtgtcctc agaagctaac catctcctgg tttgccatcg ttttgctggt gtctccactc       60

atggccatgt gggagctgga gaaagacgtt tatgttgtag aggtggactg gactcccgat      120

gcccctggag aaacagtgaa cctcacctgt gacacgcctg aagaagatga catcacctgg      180

acctcagacc agagacatgg agtcataggc tctggaaaga ccctgaccat cactgtcaaa      240

gagtttctag atgctggcca gtacacctgc cacaaaggag gcgagactct gagccactca      300

catctgctgc tccacaagaa ggaaaatgga atttggtcca ctgaaatttt aaaaaatttc      360

aaaaacaaga ctttcctgaa gtgtgaagca ccaaattact ccggacggtt cacgtgctca      420

tggctggtgc aaagaaacat ggacttgaag ttcaacatca agagcagtag cagttcccct      480

gactctcggg cagtgacatg tggaatggcg tctctgtctg cagagaaggt cacactggac      540

caaagggact atgagaagta ttcagtgtcc tgccaggagg atgtcacctg cccaactgcc      600

gaggagaccc tgcccattga actggcgttg gaagcacggc agcagaataa atatgagaac      660

tacagcacca gcttcttcat cagggacatc atcaaaccag acccgcccaa gaacttgcag      720

atgaagcctt tgaagaactc acaggtggag gtcagctggg agtaccctga ctcctggagc      780

actccccatt cctacttctc cctcaagttc tttgttcgaa tccagcgcaa gaaagaaaag      840

atgaaggaga cagaggaggg gtgtaaccag aaaggtgcgt tcctcgtaga gaagacatct      900

accgaagtcc aatgcaaagg cgggaatgtc tgcgtgcaag ctcaggatcg ctattacaat      960

tcctcatgca gcaagtgggc atgtgttccc tgcagggtcc gatcctag                  1008


<210>  3
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  3
atgtgtccag cgcgcagcct cctccttgtg gctaccctgg tcctcctgga ccacctcagt       60

ttggccagaa acctccccgt ggccactcca gacccaggaa tgttcccatg ccttcaccac      120

tcccaaaacc tgctgagggc cgtcagcaac atgctccaga aggccagaca aactctagaa      180

ttttaccctt gcacttctga agagattgat catgaagata tcacaaaaga taaaaccagc      240

acagtggagg cctgtttacc attggaatta accaagaatg agagttgcct aaattccaga      300

gagacctctt tcataactaa tgggagttgc ctggcctcca gaaagacctc ttttatgatg      360

gccctgtgcc ttagtagtat ttatgaagac ttgaagatgt accaggtgga gttcaagacc      420

atgaatgcaa agcttctgat ggatcctaag aggcagatct ttctagatca aaacatgctg      480

gcagttattg atgagctgat gcaggccctg aatttcaaca gtgagactgt gccacaaaaa      540

tcctcccttg aagaaccgga tttttataaa actaaaatca agctctgcat acttcttcat      600

gctttcagaa ttcgggcagt gactattgac agagtgacga gctatctgaa tgcttcctaa      660


<210>  4
<211>  987
<212>  DNA
<213>  Homo sapiens

<400>  4
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc       60

gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat      120

gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg      180

accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa      240

gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg      300

ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag      360

aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc      420

acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga      480

ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc      540

agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca      600

gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat      660

gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac      720

ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac      780

acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag      840

agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc      900

cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc      960

gaatgggcat ctgtgccctg cagttag                                          987


<210>  5
<211>  215
<212>  PRT
<213>  Mus musculus

<400>  5

Met Cys Gln Ser Arg Tyr Leu Leu Phe Leu Ala Thr Leu Ala Leu Leu 
1               5                   10                  15      


Asn His Leu Ser Leu Ala Arg Val Ile Pro Val Ser Gly Pro Ala Arg 
            20                  25                  30          


Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val 
        35                  40                  45              


Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp 
    50                  55                  60                  


Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr 
65                  70                  75                  80  


Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg 
                85                  90                  95      


Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr 
            100                 105                 110         


Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys 
        115                 120                 125             


Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His 
    130                 135                 140                 


Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp 
145                 150                 155                 160 


Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys 
                165                 170                 175     


Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys 
            180                 185                 190         


Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val 
        195                 200                 205             


Met Gly Tyr Leu Ser Ser Ala 
    210                 215 


<210>  6
<211>  335
<212>  PRT
<213>  Mus musculus

<400>  6

Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
                325                 330                 335 


<210>  7
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 
1               5                   10                  15      


Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215                 


<210>  8
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  9
<211>  878
<212>  PRT
<213>  Drosophila melanogaster

<400>  9

Met Lys Arg Arg Trp Ser Asn Asn Gly Gly Phe Met Arg Leu Pro Glu 
1               5                   10                  15      


Glu Ser Ser Ser Glu Val Thr Ser Ser Ser Asn Gly Leu Val Leu Pro 
            20                  25                  30          


Ser Gly Val Asn Met Ser Pro Ser Ser Leu Asp Ser His Asp Tyr Cys 
        35                  40                  45              


Asp Gln Asp Leu Trp Leu Cys Gly Asn Glu Ser Gly Ser Phe Gly Gly 
    50                  55                  60                  


Ser Asn Gly His Gly Leu Ser Gln Gln Gln Gln Ser Val Ile Thr Leu 
65                  70                  75                  80  


Ala Met His Gly Cys Ser Ser Thr Leu Pro Ala Gln Thr Thr Ile Ile 
                85                  90                  95      


Pro Ile Asn Gly Asn Ala Asn Gly Asn Gly Gly Ser Thr Asn Gly Gln 
            100                 105                 110         


Tyr Val Pro Gly Ala Thr Asn Leu Gly Ala Leu Ala Asn Gly Met Leu 
        115                 120                 125             


Asn Gly Gly Phe Asn Gly Met Gln Gln Gln Ile Gln Asn Gly His Gly 
    130                 135                 140                 


Leu Ile Asn Ser Thr Thr Pro Ser Thr Pro Thr Thr Pro Leu His Leu 
145                 150                 155                 160 


Gln Gln Asn Leu Gly Gly Ala Gly Gly Gly Gly Ile Gly Gly Met Gly 
                165                 170                 175     


Ile Leu His His Ala Asn Gly Thr Pro Asn Gly Leu Ile Gly Val Val 
            180                 185                 190         


Gly Gly Gly Gly Gly Val Gly Leu Gly Val Gly Gly Gly Gly Val Gly 
        195                 200                 205             


Gly Leu Gly Met Gln His Thr Pro Arg Ser Asp Ser Val Asn Ser Ile 
    210                 215                 220                 


Ser Ser Gly Arg Asp Asp Leu Ser Pro Ser Ser Ser Leu Asn Gly Tyr 
225                 230                 235                 240 


Ser Ala Asn Glu Ser Cys Asp Ala Lys Lys Ser Lys Lys Gly Pro Ala 
                245                 250                 255     


Pro Arg Val Gln Glu Glu Leu Cys Leu Val Cys Gly Asp Arg Ala Ser 
            260                 265                 270         


Gly Tyr His Tyr Asn Ala Leu Thr Cys Glu Gly Cys Lys Gly Phe Phe 
        275                 280                 285             


Arg Arg Ser Val Thr Lys Ser Ala Val Tyr Cys Cys Lys Phe Gly Arg 
    290                 295                 300                 


Ala Cys Glu Met Asp Met Tyr Met Arg Arg Lys Cys Gln Glu Cys Arg 
305                 310                 315                 320 


Leu Lys Lys Cys Leu Ala Val Gly Met Arg Pro Glu Cys Val Val Pro 
                325                 330                 335     


Glu Asn Gln Cys Ala Met Lys Arg Arg Glu Lys Lys Ala Gln Lys Glu 
            340                 345                 350         


Lys Asp Lys Met Thr Thr Ser Pro Ser Ser Gln His Gly Gly Asn Gly 
        355                 360                 365             


Ser Leu Ala Ser Gly Gly Gly Gln Asp Phe Val Lys Lys Glu Ile Leu 
    370                 375                 380                 


Asp Leu Met Thr Cys Glu Pro Pro Gln His Ala Thr Ile Pro Leu Leu 
385                 390                 395                 400 


Pro Asp Glu Ile Leu Ala Lys Cys Gln Ala Arg Asn Ile Pro Ser Leu 
                405                 410                 415     


Thr Tyr Asn Gln Leu Ala Val Ile Tyr Lys Leu Ile Trp Tyr Gln Asp 
            420                 425                 430         


Gly Tyr Glu Gln Pro Ser Glu Glu Asp Leu Arg Arg Ile Met Ser Gln 
        435                 440                 445             


Pro Asp Glu Asn Glu Ser Gln Thr Asp Val Ser Phe Arg His Ile Thr 
    450                 455                 460                 


Glu Ile Thr Ile Leu Thr Val Gln Leu Ile Val Glu Phe Ala Lys Gly 
465                 470                 475                 480 


Leu Pro Ala Phe Thr Lys Ile Pro Gln Glu Asp Gln Ile Thr Leu Leu 
                485                 490                 495     


Lys Ala Cys Ser Ser Glu Val Met Met Leu Arg Met Ala Arg Arg Tyr 
            500                 505                 510         


Asp His Ser Ser Asp Ser Ile Phe Phe Ala Asn Asn Arg Ser Tyr Thr 
        515                 520                 525             


Arg Asp Ser Tyr Lys Met Ala Gly Met Ala Asp Asn Ile Glu Asp Leu 
    530                 535                 540                 


Leu His Phe Cys Arg Gln Met Phe Ser Met Lys Val Asp Asn Val Glu 
545                 550                 555                 560 


Tyr Ala Leu Leu Thr Ala Ile Val Ile Phe Ser Asp Arg Pro Gly Leu 
                565                 570                 575     


Glu Lys Ala Gln Leu Val Glu Ala Ile Gln Ser Tyr Tyr Ile Asp Thr 
            580                 585                 590         


Leu Arg Ile Tyr Ile Leu Asn Arg His Cys Gly Asp Ser Met Ser Leu 
        595                 600                 605             


Val Phe Tyr Ala Lys Leu Leu Ser Ile Leu Thr Glu Leu Arg Thr Leu 
    610                 615                 620                 


Gly Asn Gln Asn Ala Glu Met Cys Phe Ser Leu Lys Leu Lys Asn Arg 
625                 630                 635                 640 


Lys Leu Pro Lys Phe Leu Glu Glu Ile Trp Asp Val His Ala Ile Pro 
                645                 650                 655     


Pro Ser Val Gln Ser His Leu Gln Ile Thr Gln Glu Glu Asn Glu Arg 
            660                 665                 670         


Leu Glu Arg Ala Glu Arg Met Arg Ala Ser Val Gly Gly Ala Ile Thr 
        675                 680                 685             


Ala Gly Ile Asp Cys Asp Ser Ala Ser Thr Ser Ala Ala Ala Ala Ala 
    690                 695                 700                 


Ala Gln His Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Ser Ser Leu 
705                 710                 715                 720 


Thr Gln Asn Asp Ser Gln His Gln Thr Gln Pro Gln Leu Gln Pro Gln 
                725                 730                 735     


Leu Pro Pro Gln Leu Gln Gly Gln Leu Gln Pro Gln Leu Gln Pro Gln 
            740                 745                 750         


Leu Gln Thr Gln Leu Gln Pro Gln Ile Gln Pro Gln Pro Gln Leu Leu 
        755                 760                 765             


Pro Val Ser Ala Pro Val Pro Ala Ser Val Thr Ala Pro Gly Ser Leu 
    770                 775                 780                 


Ser Ala Val Ser Thr Ser Ser Glu Tyr Met Gly Gly Ser Ala Ala Ile 
785                 790                 795                 800 


Gly Pro Ile Thr Pro Ala Thr Thr Ser Ser Ile Thr Ala Ala Val Thr 
                805                 810                 815     


Ala Ser Ser Thr Thr Ser Ala Val Pro Met Gly Asn Gly Val Gly Val 
            820                 825                 830         


Gly Val Gly Val Gly Gly Asn Val Ser Met Tyr Ala Asn Ala Gln Thr 
        835                 840                 845             


Ala Met Ala Leu Met Gly Val Ala Leu His Ser His Gln Glu Gln Leu 
    850                 855                 860                 


Ile Gly Gly Val Ala Val Lys Ser Glu His Ser Thr Thr Ala 
865                 870                 875             


<210>  10
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nivolumab heavy chain sequence

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210>  11
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nivolumab light chain sequence

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  12
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12 p40

<400>  12

Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
                325                 330                 335 


<210>  13
<211>  1008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-12 p40

<400>  13
atgtgccccc agaagctgac catcagctgg ttcgccatcg tgctgctggt gagccccctg       60

atggccatgt gggagctgga gaaggacgtg tacgtggtgg aggtggactg gacccccgac      120

gcccccggcg agaccgtgaa cctgacttgc gacacccccg aggaggacga catcacctgg      180

accagcgacc agagacacgg cgtcatcggc agcggcaaga ccctgaccat caccgtgaag      240

gagttcctgg acgccggaca gtacacctgt cacaagggcg gcgagaccct gagccacagc      300

cacctgttgc tgcacaagaa ggagaacggc atctggagca ccgagatcct gaagaacttc      360

aagaacaaga ccttcctgaa gtgcgaggcc cccaactaca gcggcagatt cacctgtagc      420

tggctggtgc agagaaacat ggacctgaag ttcaacatca agagcagcag cagcagcccc      480

gacagcagag ccgtgacatg cggcatggcc agcctgagcg ccgagaaggt gaccctggac      540

cagagagact acgagaagta cagcgtgagc tgccaggagg acgtgacctg tcccaccgcc      600

gaggagaccc tgcccatcga gcttgccctg gaagccagac agcagaacaa gtacgagaac      660

tacagcacca gcttcttcat cagagacatc atcaagcccg acccccccaa gaacctccag      720

atgaagcccc tgaagaacag ccaggtggag gtgtcctggg agtaccccga cagctggagc      780

accccccaca gctacttcag cctgaagttc ttcgtgagaa tccagagaaa gaaggagaag      840

atgaaggaga ccgaggaggg ctgcaaccag aagggcgctt tcctggtgga gaaaaccagc      900

accgaggtgc agtgcaaggg cggcaacgtg tgtgtgcagg cccaggacag atactacaac      960

agcagctgct ccaagtgggc ctgcgtgccc tgccgcgtga gaagctga                  1008


<210>  14
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12 p35

<400>  14

Met Cys Gln Ser Arg Tyr Leu Leu Phe Leu Ala Thr Leu Ala Leu Leu 
1               5                   10                  15      


Asn His Leu Ser Leu Ala Arg Val Ile Pro Val Ser Gly Pro Ala Arg 
            20                  25                  30          


Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val 
        35                  40                  45              


Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp 
    50                  55                  60                  


Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr 
65                  70                  75                  80  


Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg 
                85                  90                  95      


Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr 
            100                 105                 110         


Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys 
        115                 120                 125             


Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His 
    130                 135                 140                 


Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp 
145                 150                 155                 160 


Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys 
                165                 170                 175     


Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys 
            180                 185                 190         


Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val 
        195                 200                 205             


Met Gly Tyr Leu Ser Ser Ala 
    210                 215 


<210>  15
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-12 p35

<400>  15
atgtgccaga gcagatacct gttgttcctg gctaccctgg ccctgctgaa ccacctgagc       60

ctggcccgcg tgatccccgt gagcggcccc gccagatgcc tgagccagag cagaaacctg      120

ttgaaaacaa ccgacgacat ggtgaaaacc gccagagaga agctgaagca ctacagctgc      180

accgccgagg acatcgacca cgaggacatc accagagacc agaccagcac cctgaaaacc      240

tgtctgcccc tggagctgca caagaacgag agctgcctgg ctaccagaga gaccagcagc      300

accaccagag gcagctgcct gcccccccag aaaaccagcc tgatgatgac cctgtgcctg      360

ggcagcatct acgaggacct gaagatgtac cagaccgagt tccaggccat caacgccgcc      420

ctgcaaaacc acaaccacca gcagatcatc ctggacaagg gcatgttggt ggccatcgac      480

gagctgatgc agagcctgaa ccacaacggc gagaccctga gacagaagcc ccccgtgggc      540

gaggccgacc cctacagagt gaagatgaag ctgtgcatcc tgctgcacgc cttcagcacc      600

agagtggtga ccatcaacag agtgatgggc tacctgagca gcgcctga                   648


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  natural ecdysone receptor

<400>  16

Arg Arg Gly Gly Thr Thr Cys Ala Asn Thr Gly Ala Cys Ala Cys Tyr 
1               5                   10                  15      


Tyr 
    


<210>  17
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  natural ecdysone receptor


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  where N can refer to any naturally occurring nucleotide

<400>  17
aggtcanagg tca                                                          13


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  natural ecdysone receptor

<400>  18

Gly Gly Gly Thr Thr Gly Ala Ala Thr Gly Ala Ala Thr Thr Thr 
1               5                   10                  15  


