                               SEQUENCE LISTING

<110> JUVENA THERAPEUTICS, INC.
 
<120> HEPARIN-ASSOCIATED POLYPEPTIDES AND USES THEREOF

<130> 54275-702.601

<140>
<141>

<150> 62/809,479
<151> 2019-02-22

<150> 62/690,796
<151> 2018-06-27

<160> 70    

<170> PatentIn version 3.5

<210> 1
<211> 478
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val 
1               5                   10                  15      


Ala Leu Ala Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe 
            20                  25                  30          


Asn Val Asp Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln 
        35                  40                  45              


Ser Cys Cys Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg 
    50                  55                  60                  


Gly Asp Val Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp 
65                  70                  75                  80  


Gly Glu Glu Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro 
                85                  90                  95      


Ser Leu Thr Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu Gln 
            100                 105                 110         


Thr Pro Val Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro Glu Val Gly 
        115                 120                 125             


Ala Ser Lys Pro Glu Gly Ile Asp Ser Arg Pro Glu Thr Leu His Pro 
    130                 135                 140                 


Gly Arg Pro Gln Pro Pro Ala Glu Glu Glu Leu Cys Ser Gly Lys Pro 
145                 150                 155                 160 


Phe Asp Ala Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg 
                165                 170                 175     


Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr 
            180                 185                 190         


Pro Lys Leu Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala 
        195                 200                 205             


Ala Phe Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly 
    210                 215                 220                 


Ser Gln Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro 
225                 230                 235                 240 


Arg Asn Ile Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala 
                245                 250                 255     


Ala Leu Ala Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr 
            260                 265                 270         


Phe Phe Lys Gly Lys Gln Tyr Trp Glu Tyr Gln Phe Gln His Gln Pro 
        275                 280                 285             


Ser Gln Glu Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His 
    290                 295                 300                 


Phe Ala Met Met Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu 
305                 310                 315                 320 


Phe Trp Gly Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser 
                325                 330                 335     


Arg Asp Trp His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly 
            340                 345                 350         


Arg Ile Tyr Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala Lys Lys 
        355                 360                 365             


Gln Arg Phe Arg His Arg Asn Arg Lys Gly Tyr Arg Ser Gln Arg Gly 
    370                 375                 380                 


His Ser Arg Gly Arg Asn Gln Asn Ser Arg Arg Pro Ser Arg Ala Thr 
385                 390                 395                 400 


Trp Leu Ser Leu Phe Ser Ser Glu Glu Ser Asn Leu Gly Ala Asn Asn 
                405                 410                 415     


Tyr Asp Asp Tyr Arg Met Asp Trp Leu Val Pro Ala Thr Cys Glu Pro 
            420                 425                 430         


Ile Gln Ser Val Phe Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val Asn 
        435                 440                 445             


Leu Arg Thr Arg Arg Val Asp Thr Val Asp Pro Pro Tyr Pro Arg Ser 
    450                 455                 460                 


Ile Ala Gln Tyr Trp Leu Gly Cys Pro Ala Pro Gly His Leu 
465                 470                 475             


<210> 2
<211> 302
<212> PRT
<213> Homo sapiens

<400> 2
Met Cys Ala Glu Arg Leu Gly Gln Phe Met Thr Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Thr Phe Asp Pro Ala Arg Gly Thr Asp Ala Thr Asn Pro Pro Glu 
            20                  25                  30          


Gly Pro Gln Asp Arg Ser Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln 
        35                  40                  45              


Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly 
    50                  55                  60                  


Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Arg Gly 
65                  70                  75                  80  


Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp 
                85                  90                  95      


Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Lys Cys Lys Ala His 
            100                 105                 110         


Ala Leu Arg His Arg Phe Gly Cys Ile Ser Arg Lys Cys Pro Ala Ile 
        115                 120                 125             


Arg Glu Met Val Ser Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp 
    130                 135                 140                 


Leu Cys Ala Ala Ala Gln Glu Asn Thr Arg Val Ile Val Glu Met Ile 
145                 150                 155                 160 


His Phe Lys Asp Leu Leu Leu His Glu Pro Tyr Val Asp Leu Val Asn 
                165                 170                 175     


Leu Leu Leu Thr Cys Gly Glu Glu Val Lys Glu Ala Ile Thr His Ser 
            180                 185                 190         


Val Gln Val Gln Cys Glu Gln Asn Trp Gly Ser Leu Cys Ser Ile Leu 
        195                 200                 205             


Ser Phe Cys Thr Ser Ala Ile Gln Lys Pro Pro Thr Ala Pro Pro Glu 
    210                 215                 220                 


Arg Gln Pro Gln Val Asp Arg Thr Lys Leu Ser Arg Ala His His Gly 
225                 230                 235                 240 


Glu Ala Gly His His Leu Pro Glu Pro Ser Ser Arg Glu Thr Gly Arg 
                245                 250                 255     


Gly Ala Lys Gly Glu Arg Gly Ser Lys Ser His Pro Asn Ala His Ala 
            260                 265                 270         


Arg Gly Arg Val Gly Gly Leu Gly Ala Gln Gly Pro Ser Gly Ser Ser 
        275                 280                 285             


Glu Trp Glu Asp Glu Gln Ser Glu Tyr Ser Asp Ile Arg Arg 
    290                 295                 300         


<210> 3
<211> 2068
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Lys Ser Arg Lys  Val Pro His 
    1745                 1750                 1755             


Thr Val  Leu Asn Leu Lys Glu  Pro Leu Tyr Val Gly  Gly Ala Pro 
    1760                 1765                 1770             


Asp Phe  Ser Lys Leu Ala Arg  Ala Ala Ala Val Ser  Ser Gly Phe 
    1775                 1780                 1785             


Asp Gly  Ala Ile Gln Leu Val  Ser Leu Gly Gly Arg  Gln Leu Leu 
    1790                 1795                 1800             


Thr Pro  Glu His Val Leu Arg  Gln Val Asp Val Thr  Ser Phe Ala 
    1805                 1810                 1815             


Gly His  Pro Cys Thr Arg Ala  Ser Gly His Pro Cys  Leu Asn Gly 
    1820                 1825                 1830             


Ala Ser  Cys Val Pro Arg Glu  Ala Ala Tyr Val Cys  Leu Cys Pro 
    1835                 1840                 1845             


Gly Gly  Phe Ser Gly Pro His  Cys Glu Lys Gly Leu  Val Glu Lys 
    1850                 1855                 1860             


Ser Ala  Gly Asp Val Asp Thr  Leu Ala Phe Asp Gly  Arg Thr Phe 
    1865                 1870                 1875             


Val Glu  Tyr Leu Asn Ala Val  Thr Glu Ser Glu Leu  Ala Asn Glu 
    1880                 1885                 1890             


Ile Pro  Val Pro Glu Thr Leu  Asp Ser Gly Ala Leu  His Ser Glu 
    1895                 1900                 1905             


Lys Ala  Leu Gln Ser Asn His  Phe Glu Leu Ser Leu  Arg Thr Glu 
    1910                 1915                 1920             


Ala Thr  Gln Gly Leu Val Leu  Trp Ser Gly Lys Ala  Thr Glu Arg 
    1925                 1930                 1935             


Ala Asp  Tyr Val Ala Leu Ala  Ile Val Asp Gly His  Leu Gln Leu 
    1940                 1945                 1950             


Ser Tyr  Asn Leu Gly Ser Gln  Pro Val Val Leu Arg  Ser Thr Val 
    1955                 1960                 1965             


Pro Val  Asn Thr Asn Arg Trp  Leu Arg Val Val Ala  His Arg Glu 
    1970                 1975                 1980             


Gln Arg  Glu Gly Ser Leu Gln  Val Gly Asn Glu Ala  Pro Val Thr 
    1985                 1990                 1995             


Gly Ser  Ser Pro Leu Gly Ala  Thr Gln Leu Asp Thr  Asp Gly Ala 
    2000                 2005                 2010             


Leu Trp  Leu Gly Gly Leu Pro  Glu Leu Pro Val Gly  Pro Ala Leu 
    2015                 2020                 2025             


Pro Lys  Ala Tyr Gly Thr Gly  Phe Val Gly Cys Leu  Arg Asp Val 
    2030                 2035                 2040             


Val Val  Gly Arg His Pro Leu  His Leu Leu Glu Asp  Ala Val Thr 
    2045                 2050                 2055             


Lys Pro  Glu Leu Arg Pro Cys  Pro Thr Pro 
    2060                 2065             


<210> 4
<211> 1172
<212> PRT
<213> Homo sapiens

<400> 4
Met Val Trp Arg Leu Val Leu Leu Ala Leu Trp Val Trp Pro Ser Thr 
1               5                   10                  15      


Gln Ala Gly His Gln Asp Lys Asp Thr Thr Phe Asp Leu Phe Ser Ile 
            20                  25                  30          


Ser Asn Ile Asn Arg Lys Thr Ile Gly Ala Lys Gln Phe Arg Gly Pro 
        35                  40                  45              


Asp Pro Gly Val Pro Ala Tyr Arg Phe Val Arg Phe Asp Tyr Ile Pro 
    50                  55                  60                  


Pro Val Asn Ala Asp Asp Leu Ser Lys Ile Thr Lys Ile Met Arg Gln 
65                  70                  75                  80  


Lys Glu Gly Phe Phe Leu Thr Ala Gln Leu Lys Gln Asp Gly Lys Ser 
                85                  90                  95      


Arg Gly Thr Leu Leu Ala Leu Glu Gly Pro Gly Leu Ser Gln Arg Gln 
            100                 105                 110         


Phe Glu Ile Val Ser Asn Gly Pro Ala Asp Thr Leu Asp Leu Thr Tyr 
        115                 120                 125             


Trp Ile Asp Gly Thr Arg His Val Val Ser Leu Glu Asp Val Gly Leu 
    130                 135                 140                 


Ala Asp Ser Gln Trp Lys Asn Val Thr Val Gln Val Ala Gly Glu Thr 
145                 150                 155                 160 


Tyr Ser Leu His Val Gly Cys Asp Leu Ile Asp Ser Phe Ala Leu Asp 
                165                 170                 175     


Glu Pro Phe Tyr Glu His Leu Gln Ala Glu Lys Ser Arg Met Tyr Val 
            180                 185                 190         


Ala Lys Gly Ser Ala Arg Glu Ser His Phe Arg Gly Leu Leu Gln Asn 
        195                 200                 205             


Val His Leu Val Phe Glu Asn Ser Val Glu Asp Ile Leu Ser Lys Lys 
    210                 215                 220                 


Gly Cys Gln Gln Gly Gln Gly Ala Glu Ile Asn Ala Ile Ser Glu Asn 
225                 230                 235                 240 


Thr Glu Thr Leu Arg Leu Gly Pro His Val Thr Thr Glu Tyr Val Gly 
                245                 250                 255     


Pro Ser Ser Glu Arg Arg Pro Glu Val Cys Glu Arg Ser Cys Glu Glu 
            260                 265                 270         


Leu Gly Asn Met Val Gln Glu Leu Ser Gly Leu His Val Leu Val Asn 
        275                 280                 285             


Gln Leu Ser Glu Asn Leu Lys Arg Val Ser Asn Asp Asn Gln Phe Leu 
    290                 295                 300                 


Trp Glu Leu Ile Gly Gly Pro Pro Lys Thr Arg Asn Met Ser Ala Cys 
305                 310                 315                 320 


Trp Gln Asp Gly Arg Phe Phe Ala Glu Asn Glu Thr Trp Val Val Asp 
                325                 330                 335     


Ser Cys Thr Thr Cys Thr Cys Lys Lys Phe Lys Thr Ile Cys His Gln 
            340                 345                 350         


Ile Thr Cys Pro Pro Ala Thr Cys Ala Ser Pro Ser Phe Val Glu Gly 
        355                 360                 365             


Glu Cys Cys Pro Ser Cys Leu His Ser Val Asp Gly Glu Glu Gly Trp 
    370                 375                 380                 


Ser Pro Trp Ala Glu Trp Thr Gln Cys Ser Val Thr Cys Gly Ser Gly 
385                 390                 395                 400 


Thr Gln Gln Arg Gly Arg Ser Cys Asp Val Thr Ser Asn Thr Cys Leu 
                405                 410                 415     


Gly Pro Ser Ile Gln Thr Arg Ala Cys Ser Leu Ser Lys Cys Asp Thr 
            420                 425                 430         


Arg Ile Arg Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser 
        435                 440                 445             


Cys Ser Val Thr Cys Gly Val Gly Asn Ile Thr Arg Ile Arg Leu Cys 
    450                 455                 460                 


Asn Ser Pro Val Pro Gln Met Gly Gly Lys Asn Cys Lys Gly Ser Gly 
465                 470                 475                 480 


Arg Glu Thr Lys Ala Cys Gln Gly Ala Pro Cys Pro Ile Asp Gly Arg 
                485                 490                 495     


Trp Ser Pro Trp Ser Pro Trp Ser Ala Cys Thr Val Thr Cys Ala Gly 
            500                 505                 510         


Gly Ile Arg Glu Arg Thr Arg Val Cys Asn Ser Pro Glu Pro Gln Tyr 
        515                 520                 525             


Gly Gly Lys Ala Cys Val Gly Asp Val Gln Glu Arg Gln Met Cys Asn 
    530                 535                 540                 


Lys Arg Ser Cys Pro Val Asp Gly Cys Leu Ser Asn Pro Cys Phe Pro 
545                 550                 555                 560 


Gly Ala Gln Cys Ser Ser Phe Pro Asp Gly Ser Trp Ser Cys Gly Ser 
                565                 570                 575     


Cys Pro Val Gly Phe Leu Gly Asn Gly Thr His Cys Glu Asp Leu Asp 
            580                 585                 590         


Glu Cys Ala Leu Val Pro Asp Ile Cys Phe Ser Thr Ser Lys Val Pro 
        595                 600                 605             


Arg Cys Val Asn Thr Gln Pro Gly Phe His Cys Leu Pro Cys Pro Pro 
    610                 615                 620                 


Arg Tyr Arg Gly Asn Gln Pro Val Gly Val Gly Leu Glu Ala Ala Lys 
625                 630                 635                 640 


Thr Glu Lys Gln Val Cys Glu Pro Glu Asn Pro Cys Lys Asp Lys Thr 
                645                 650                 655     


His Asn Cys His Lys His Ala Glu Cys Ile Tyr Leu Gly His Phe Ser 
            660                 665                 670         


Asp Pro Met Tyr Lys Cys Glu Cys Gln Thr Gly Tyr Ala Gly Asp Gly 
        675                 680                 685             


Leu Ile Cys Gly Glu Asp Ser Asp Leu Asp Gly Trp Pro Asn Leu Asn 
    690                 695                 700                 


Leu Val Cys Ala Thr Asn Ala Thr Tyr His Cys Ile Lys Asp Asn Cys 
705                 710                 715                 720 


Pro His Leu Pro Asn Ser Gly Gln Glu Asp Phe Asp Lys Asp Gly Ile 
                725                 730                 735     


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Thr Asp Glu 
            740                 745                 750         


Lys Asp Asn Cys Gln Leu Leu Phe Asn Pro Arg Gln Ala Asp Tyr Asp 
        755                 760                 765             


Lys Asp Glu Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Val His Asn 
    770                 775                 780                 


Pro Ala Gln Ile Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ser 
785                 790                 795                 800 


Val Asp Ile Asp Gly Asp Asp Val Phe Asn Glu Arg Asp Asn Cys Pro 
                805                 810                 815     


Tyr Val Tyr Asn Thr Asp Gln Arg Asp Thr Asp Gly Asp Gly Val Gly 
            820                 825                 830         


Asp His Cys Asp Asn Cys Pro Leu Val His Asn Pro Asp Gln Thr Asp 
        835                 840                 845             


Val Asp Asn Asp Leu Val Gly Asp Gln Cys Asp Asn Asn Glu Asp Ile 
    850                 855                 860                 


Asp Asp Asp Gly His Gln Asn Asn Gln Asp Asn Cys Pro Tyr Ile Ser 
865                 870                 875                 880 


Asn Ala Asn Gln Ala Asp His Asp Arg Asp Gly Gln Gly Asp Ala Cys 
                885                 890                 895     


Asp Pro Asp Asp Asp Asn Asp Gly Val Pro Asp Asp Arg Asp Asn Cys 
            900                 905                 910         


Arg Leu Val Phe Asn Pro Asp Gln Glu Asp Leu Asp Gly Asp Gly Arg 
        915                 920                 925             


Gly Asp Ile Cys Lys Asp Asp Phe Asp Asn Asp Asn Ile Pro Asp Ile 
    930                 935                 940                 


Asp Asp Val Cys Pro Glu Asn Asn Ala Ile Ser Glu Thr Asp Phe Arg 
945                 950                 955                 960 


Asn Phe Gln Met Val Pro Leu Asp Pro Lys Gly Thr Thr Gln Ile Asp 
                965                 970                 975     


Pro Asn Trp Val Ile Arg His Gln Gly Lys Glu Leu Val Gln Thr Ala 
            980                 985                 990         


Asn Ser Asp Pro Gly Ile Ala Val  Gly Phe Asp Glu Phe  Gly Ser Val 
        995                 1000                 1005             


Asp Phe  Ser Gly Thr Phe Tyr  Val Asn Thr Asp Arg  Asp Asp Asp 
    1010                 1015                 1020             


Tyr Ala  Gly Phe Val Phe Gly  Tyr Gln Ser Ser Ser  Arg Phe Tyr 
    1025                 1030                 1035             


Val Val  Met Trp Lys Gln Val  Thr Gln Thr Tyr Trp  Glu Asp Gln 
    1040                 1045                 1050             


Pro Thr  Arg Ala Tyr Gly Tyr  Ser Gly Val Ser Leu  Lys Val Val 
    1055                 1060                 1065             


Asn Ser  Thr Thr Gly Thr Gly  Glu His Leu Arg Asn  Ala Leu Trp 
    1070                 1075                 1080             


His Thr  Gly Asn Thr Pro Gly  Gln Val Arg Thr Leu  Trp His Asp 
    1085                 1090                 1095             


Pro Arg  Asn Ile Gly Trp Lys  Asp Tyr Thr Ala Tyr  Arg Trp His 
    1100                 1105                 1110             


Leu Thr  His Arg Pro Lys Thr  Gly Tyr Ile Arg Val  Leu Val His 
    1115                 1120                 1125             


Glu Gly  Lys Gln Val Met Ala  Asp Ser Gly Pro Ile  Tyr Asp Gln 
    1130                 1135                 1140             


Thr Tyr  Ala Gly Gly Arg Leu  Gly Leu Phe Val Phe  Ser Gln Glu 
    1145                 1150                 1155             


Met Val  Tyr Phe Ser Asp Leu  Lys Tyr Glu Cys Arg  Asp Ile 
    1160                 1165                 1170         


<210> 5
<211> 344
<212> PRT
<213> Homo sapiens

<400> 5
Met Val Arg Ala Arg His Gln Pro Gly Gly Leu Cys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Cys Gln Phe Met Glu Asp Arg Ser Ala Gln Ala Gly Asn Cys 
            20                  25                  30          


Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu Tyr Lys Thr 
        35                  40                  45              


Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu Ser Thr Ser 
    50                  55                  60                  


Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys Trp Met Ile 
65                  70                  75                  80  


Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu Thr Cys Glu 
                85                  90                  95      


Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn Lys Lys Asn 
            100                 105                 110         


Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile Thr Trp Lys 
        115                 120                 125             


Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn Glu Cys Ala 
    130                 135                 140                 


Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu Val Gln Tyr 
145                 150                 155                 160 


Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys Pro Gly Ser 
                165                 170                 175     


Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys Val Thr Cys 
            180                 185                 190         


Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr Leu Cys Gly 
        195                 200                 205             


Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg Lys Ala Thr 
    210                 215                 220                 


Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly Lys Cys Ile 
225                 230                 235                 240 


Lys Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys Lys Cys 
                245                 250                 255     


Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys Asp Glu 
            260                 265                 270         


Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn 
        275                 280                 285             


Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys Ser Ser 
    290                 295                 300                 


Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn Ser Ile Ser 
305                 310                 315                 320 


Glu Asp Thr Glu Glu Glu Glu Glu Asp Glu Asp Gln Asp Tyr Ser Phe 
                325                 330                 335     


Pro Ile Ser Ser Ile Leu Glu Trp 
            340                 


<210> 6
<211> 836
<212> PRT
<213> Homo sapiens

<400> 6
Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Thr Thr Lys 
            660                 665                 670         


Ile Ile Thr Lys Val Val Glu Pro Lys Ile Lys Val Ile Glu Gly Ser 
        675                 680                 685             


Leu Gln Pro Ile Ile Lys Thr Glu Gly Pro Thr Leu Thr Lys Val Lys 
    690                 695                 700                 


Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys Glu Gly Glu Thr Ile 
705                 710                 715                 720 


Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys Lys Tyr Thr Lys Ile 
                725                 730                 735     


Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys Glu Thr Arg Glu Glu 
            740                 745                 750         


Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr Arg Ile Ser Thr Gly 
        755                 760                 765             


Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu Leu Gln Glu Glu Val 
    770                 775                 780                 


Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp Gly His Leu Phe Glu 
785                 790                 795                 800 


Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp Thr Pro Val Arg Lys 
                805                 810                 815     


Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu 
            820                 825                 830         


Gly Arg Ser Gln 
        835     


<210> 7
<211> 216
<212> PRT
<213> Homo sapiens

<400> 7
Met Gly Ala Ala Arg Leu Leu Pro Asn Leu Thr Leu Cys Leu Gln Leu 
1               5                   10                  15      


Leu Ile Leu Cys Cys Gln Thr Gln Gly Glu Asn His Pro Ser Pro Asn 
            20                  25                  30          


Phe Asn Gln Tyr Val Arg Asp Gln Gly Ala Met Thr Asp Gln Leu Ser 
        35                  40                  45              


Arg Arg Gln Ile Arg Glu Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys 
    50                  55                  60                  


His Val Gln Val Thr Gly Arg Arg Ile Ser Ala Thr Ala Glu Asp Gly 
65                  70                  75                  80  


Asn Lys Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      


Val Arg Ile Lys Gly Ala Glu Ser Glu Lys Tyr Ile Cys Met Asn Lys 
            100                 105                 110         


Arg Gly Lys Leu Ile Gly Lys Pro Ser Gly Lys Ser Lys Asp Cys Val 
        115                 120                 125             


Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Phe Gln Asn Ala 
    130                 135                 140                 


Arg His Glu Gly Trp Phe Met Ala Phe Thr Arg Gln Gly Arg Pro Arg 
145                 150                 155                 160 


Gln Ala Ser Arg Ser Arg Gln Asn Gln Arg Glu Ala His Phe Ile Lys 
                165                 170                 175     


Arg Leu Tyr Gln Gly Gln Leu Pro Phe Pro Asn His Ala Glu Lys Gln 
            180                 185                 190         


Lys Gln Phe Glu Phe Val Gly Ser Ala Pro Thr Arg Arg Thr Lys Arg 
        195                 200                 205             


Thr Arg Arg Pro Gln Pro Leu Thr 
    210                 215     


<210> 8
<211> 961
<212> PRT
<213> Homo sapiens

<400> 8
Met Leu Ala Pro Arg Gly Ala Ala Val Leu Leu Leu His Leu Val Leu 
1               5                   10                  15      


Gln Arg Trp Leu Ala Ala Gly Ala Gln Ala Thr Pro Gln Val Phe Asp 
            20                  25                  30          


Leu Leu Pro Ser Ser Ser Gln Arg Leu Asn Pro Gly Ala Leu Leu Pro 
        35                  40                  45              


Val Leu Thr Asp Pro Ala Leu Asn Asp Leu Tyr Val Ile Ser Thr Phe 
    50                  55                  60                  


Lys Leu Gln Thr Lys Ser Ser Ala Thr Ile Phe Gly Leu Tyr Ser Ser 
65                  70                  75                  80  


Thr Asp Asn Ser Lys Tyr Phe Glu Phe Thr Val Met Gly Arg Leu Asn 
                85                  90                  95      


Lys Ala Ile Leu Arg Tyr Leu Lys Asn Asp Gly Lys Val His Leu Val 
            100                 105                 110         


Val Phe Asn Asn Leu Gln Leu Ala Asp Gly Arg Arg His Arg Ile Leu 
        115                 120                 125             


Leu Arg Leu Ser Asn Leu Gln Arg Gly Ala Gly Ser Leu Glu Leu Tyr 
    130                 135                 140                 


Leu Asp Cys Ile Gln Val Asp Ser Val His Asn Leu Pro Arg Ala Phe 
145                 150                 155                 160 


Ala Gly Pro Ser Gln Lys Pro Glu Thr Ile Glu Leu Arg Thr Phe Gln 
                165                 170                 175     


Arg Lys Pro Gln Asp Phe Leu Glu Glu Leu Lys Leu Val Val Arg Gly 
            180                 185                 190         


Ser Leu Phe Gln Val Ala Ser Leu Gln Asp Cys Phe Leu Gln Gln Ser 
        195                 200                 205             


Glu Pro Leu Ala Ala Thr Gly Thr Gly Asp Phe Asn Arg Gln Phe Leu 
    210                 215                 220                 


Gly Gln Met Thr Gln Leu Asn Gln Leu Leu Gly Glu Val Lys Asp Leu 
225                 230                 235                 240 


Leu Arg Gln Gln Val Lys Glu Thr Ser Phe Leu Arg Asn Thr Ile Ala 
                245                 250                 255     


Glu Cys Gln Ala Cys Gly Pro Leu Lys Phe Gln Ser Pro Thr Pro Ser 
            260                 265                 270         


Thr Val Val Pro Pro Ala Pro Pro Ala Pro Pro Thr Arg Pro Pro Arg 
        275                 280                 285             


Arg Cys Asp Ser Asn Pro Cys Phe Arg Gly Val Gln Cys Thr Asp Ser 
    290                 295                 300                 


Arg Asp Gly Phe Gln Cys Gly Pro Cys Pro Glu Gly Tyr Thr Gly Asn 
305                 310                 315                 320 


Gly Ile Thr Cys Ile Asp Val Asp Glu Cys Lys Tyr His Pro Cys Tyr 
                325                 330                 335     


Pro Gly Val His Cys Ile Asn Leu Ser Pro Gly Phe Arg Cys Asp Ala 
            340                 345                 350         


Cys Pro Val Gly Phe Thr Gly Pro Met Val Gln Gly Val Gly Ile Ser 
        355                 360                 365             


Phe Ala Lys Ser Asn Lys Gln Val Cys Thr Asp Ile Asp Glu Cys Arg 
    370                 375                 380                 


Asn Gly Ala Cys Val Pro Asn Ser Ile Cys Val Asn Thr Leu Gly Ser 
385                 390                 395                 400 


Tyr Arg Cys Gly Pro Cys Lys Pro Gly Tyr Thr Gly Asp Gln Ile Arg 
                405                 410                 415     


Gly Cys Lys Ala Glu Arg Asn Cys Arg Asn Pro Glu Leu Asn Pro Cys 
            420                 425                 430         


Ser Val Asn Ala Gln Cys Ile Glu Glu Arg Gln Gly Asp Val Thr Cys 
        435                 440                 445             


Val Cys Gly Val Gly Trp Ala Gly Asp Gly Tyr Ile Cys Gly Lys Asp 
    450                 455                 460                 


Val Asp Ile Asp Ser Tyr Pro Asp Glu Glu Leu Pro Cys Ser Ala Arg 
465                 470                 475                 480 


Asn Cys Lys Lys Asp Asn Cys Lys Tyr Val Pro Asn Ser Gly Gln Glu 
                485                 490                 495     


Asp Ala Asp Arg Asp Gly Ile Gly Asp Ala Cys Asp Glu Asp Ala Asp 
            500                 505                 510         


Gly Asp Gly Ile Leu Asn Glu Gln Asp Asn Cys Val Leu Ile His Asn 
        515                 520                 525             


Val Asp Gln Arg Asn Ser Asp Lys Asp Ile Phe Gly Asp Ala Cys Asp 
    530                 535                 540                 


Asn Cys Leu Ser Val Leu Asn Asn Asp Gln Lys Asp Thr Asp Gly Asp 
545                 550                 555                 560 


Gly Arg Gly Asp Ala Cys Asp Asp Asp Met Asp Gly Asp Gly Ile Lys 
                565                 570                 575     


Asn Ile Leu Asp Asn Cys Pro Lys Phe Pro Asn Arg Asp Gln Arg Asp 
            580                 585                 590         


Lys Asp Gly Asp Gly Val Gly Asp Ala Cys Asp Ser Cys Pro Asp Val 
        595                 600                 605             


Ser Asn Pro Asn Gln Ser Asp Val Asp Asn Asp Leu Val Gly Asp Ser 
    610                 615                 620                 


Cys Asp Thr Asn Gln Asp Ser Asp Gly Asp Gly His Gln Asp Ser Thr 
625                 630                 635                 640 


Asp Asn Cys Pro Thr Val Ile Asn Ser Ala Gln Leu Asp Thr Asp Lys 
                645                 650                 655     


Asp Gly Ile Gly Asp Glu Cys Asp Asp Asp Asp Asp Asn Asp Gly Ile 
            660                 665                 670         


Pro Asp Leu Val Pro Pro Gly Pro Asp Asn Cys Arg Leu Val Pro Asn 
        675                 680                 685             


Pro Ala Gln Glu Asp Ser Asn Ser Asp Gly Val Gly Asp Ile Cys Glu 
    690                 695                 700                 


Ser Asp Phe Asp Gln Asp Gln Val Ile Asp Arg Ile Asp Val Cys Pro 
705                 710                 715                 720 


Glu Asn Ala Glu Val Thr Leu Thr Asp Phe Arg Ala Tyr Gln Thr Val 
                725                 730                 735     


Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro Asn Trp Val Val 
            740                 745                 750         


Leu Asn Gln Gly Met Glu Ile Val Gln Thr Met Asn Ser Asp Pro Gly 
        755                 760                 765             


Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val Asp Phe Glu Gly Thr 
    770                 775                 780                 


Phe His Val Asn Thr Gln Thr Asp Asp Asp Tyr Ala Gly Phe Ile Phe 
785                 790                 795                 800 


Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val Met Trp Lys Gln Thr 
                805                 810                 815     


Glu Gln Thr Tyr Trp Gln Ala Thr Pro Phe Arg Ala Val Ala Glu Pro 
            820                 825                 830         


Gly Ile Gln Leu Lys Ala Val Lys Ser Lys Thr Gly Pro Gly Glu His 
        835                 840                 845             


Leu Arg Asn Ser Leu Trp His Thr Gly Asp Thr Ser Asp Gln Val Arg 
    850                 855                 860                 


Leu Leu Trp Lys Asp Ser Arg Asn Val Gly Trp Lys Asp Lys Val Ser 
865                 870                 875                 880 


Tyr Arg Trp Phe Leu Gln His Arg Pro Gln Val Gly Tyr Ile Arg Val 
                885                 890                 895     


Arg Phe Tyr Glu Gly Ser Glu Leu Val Ala Asp Ser Gly Val Thr Ile 
            900                 905                 910         


Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val Phe Cys Phe Ser Gln 
        915                 920                 925             


Glu Asn Ile Ile Trp Ser Asn Leu Lys Tyr Arg Cys Asn Asp Thr Ile 
    930                 935                 940                 


Pro Glu Asp Phe Gln Glu Phe Gln Thr Gln Asn Phe Asp Arg Phe Asp 
945                 950                 955                 960 


Asn 
    


<210> 9
<211> 1170
<212> PRT
<213> Homo sapiens

<400> 9
Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210> 10
<211> 162
<212> PRT
<213> Homo sapiens

<400> 10
Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210> 11
<211> 180
<212> PRT
<213> Homo sapiens

<400> 11
Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210> 12
<211> 288
<212> PRT
<213> Homo sapiens

<400> 12
Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210> 13
<211> 216
<212> PRT
<213> Homo sapiens

<400> 13
Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu 
1               5                   10                  15      


Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro 
            20                  25                  30          


His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr 
        35                  40                  45              


Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala 
    50                  55                  60                  


Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu 
65                  70                  75                  80  


Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His 
                85                  90                  95      


Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu 
            100                 105                 110         


Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro 
        115                 120                 125             


Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser 
    130                 135                 140                 


Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu 
145                 150                 155                 160 


Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro 
                165                 170                 175     


Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 
            180                 185                 190         


Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 
        195                 200                 205             


Val Arg Ser Pro Ser Phe Glu Lys 
    210                 215     


<210> 14
<211> 147
<212> PRT
<213> Homo sapiens

<400> 14
Met Val Met Gly Leu Gly Val Leu Leu Leu Val Phe Val Leu Gly Leu 
1               5                   10                  15      


Gly Leu Thr Pro Pro Thr Leu Ala Gln Asp Asn Ser Arg Tyr Thr His 
            20                  25                  30          


Phe Leu Thr Gln His Tyr Asp Ala Lys Pro Gln Gly Arg Asp Asp Arg 
        35                  40                  45              


Tyr Cys Glu Ser Ile Met Arg Arg Arg Gly Leu Thr Ser Pro Cys Lys 
    50                  55                  60                  


Asp Ile Asn Thr Phe Ile His Gly Asn Lys Arg Ser Ile Lys Ala Ile 
65                  70                  75                  80  


Cys Glu Asn Lys Asn Gly Asn Pro His Arg Glu Asn Leu Arg Ile Ser 
                85                  90                  95      


Lys Ser Ser Phe Gln Val Thr Thr Cys Lys Leu His Gly Gly Ser Pro 
            100                 105                 110         


Trp Pro Pro Cys Gln Tyr Arg Ala Thr Ala Gly Phe Arg Asn Val Val 
        115                 120                 125             


Val Ala Cys Glu Asn Gly Leu Pro Val His Leu Asp Gln Ser Ile Phe 
    130                 135                 140                 


Arg Arg Pro 
145         


<210> 15
<211> 178
<212> PRT
<213> Homo sapiens

<400> 15
Met Asp Arg Ala Ala Arg Cys Ser Gly Ala Ser Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Leu Ala Leu Gly Leu Val Ile Leu His Cys Val Val Ala Asp 
            20                  25                  30          


Gly Asn Ser Thr Arg Ser Pro Glu Thr Asn Gly Leu Leu Cys Gly Asp 
        35                  40                  45              


Pro Glu Glu Asn Cys Ala Ala Thr Thr Thr Gln Ser Lys Arg Lys Gly 
    50                  55                  60                  


His Phe Ser Arg Cys Pro Lys Gln Tyr Lys His Tyr Cys Ile Lys Gly 
65                  70                  75                  80  


Arg Cys Arg Phe Val Val Ala Glu Gln Thr Pro Ser Cys Val Cys Asp 
                85                  90                  95      


Glu Gly Tyr Ile Gly Ala Arg Cys Glu Arg Val Asp Leu Phe Tyr Leu 
            100                 105                 110         


Arg Gly Asp Arg Gly Gln Ile Leu Val Ile Cys Leu Ile Ala Val Met 
        115                 120                 125             


Val Val Phe Ile Ile Leu Val Ile Gly Val Cys Thr Cys Cys His Pro 
    130                 135                 140                 


Leu Arg Lys Arg Arg Lys Arg Lys Lys Lys Glu Glu Glu Met Glu Thr 
145                 150                 155                 160 


Leu Gly Lys Asp Ile Thr Pro Ile Asn Glu Asp Ile Glu Glu Thr Asn 
                165                 170                 175     


Ile Ala 
        


<210> 16
<211> 380
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Phe Val Cys Leu Ala Ile Gly Cys Leu Tyr Thr Phe Leu Ile 
1               5                   10                  15      


Ser Thr Thr Phe Gly Cys Thr Ser Ser Ser Asp Thr Glu Ile Lys Val 
            20                  25                  30          


Asn Pro Pro Gln Asp Phe Glu Ile Val Asp Pro Gly Tyr Leu Gly Tyr 
        35                  40                  45              


Leu Tyr Leu Gln Trp Gln Pro Pro Leu Ser Leu Asp His Phe Lys Glu 
    50                  55                  60                  


Cys Thr Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 
65                  70                  75                  80  


Trp Lys Thr Ile Ile Thr Lys Asn Leu His Tyr Lys Asp Gly Phe Asp 
                85                  90                  95      


Leu Asn Lys Gly Ile Glu Ala Lys Ile His Thr Leu Leu Pro Trp Gln 
            100                 105                 110         


Cys Thr Asn Gly Ser Glu Val Gln Ser Ser Trp Ala Glu Thr Thr Tyr 
        115                 120                 125             


Trp Ile Ser Pro Gln Gly Ile Pro Glu Thr Lys Val Gln Asp Met Asp 
    130                 135                 140                 


Cys Val Tyr Tyr Asn Trp Gln Tyr Leu Leu Cys Ser Trp Lys Pro Gly 
145                 150                 155                 160 


Ile Gly Val Leu Leu Asp Thr Asn Tyr Asn Leu Phe Tyr Trp Tyr Glu 
                165                 170                 175     


Gly Leu Asp His Ala Leu Gln Cys Val Asp Tyr Ile Lys Ala Asp Gly 
            180                 185                 190         


Gln Asn Ile Gly Cys Arg Phe Pro Tyr Leu Glu Ala Ser Asp Tyr Lys 
        195                 200                 205             


Asp Phe Tyr Ile Cys Val Asn Gly Ser Ser Glu Asn Lys Pro Ile Arg 
    210                 215                 220                 


Ser Ser Tyr Phe Thr Phe Gln Leu Gln Asn Ile Val Lys Pro Leu Pro 
225                 230                 235                 240 


Pro Val Tyr Leu Thr Phe Thr Arg Glu Ser Ser Cys Glu Ile Lys Leu 
                245                 250                 255     


Lys Trp Ser Ile Pro Leu Gly Pro Ile Pro Ala Arg Cys Phe Asp Tyr 
            260                 265                 270         


Glu Ile Glu Ile Arg Glu Asp Asp Thr Thr Leu Val Thr Ala Thr Val 
        275                 280                 285             


Glu Asn Glu Thr Tyr Thr Leu Lys Thr Thr Asn Glu Thr Arg Gln Leu 
    290                 295                 300                 


Cys Phe Val Val Arg Ser Lys Val Asn Ile Tyr Cys Ser Asp Asp Gly 
305                 310                 315                 320 


Ile Trp Ser Glu Trp Ser Asp Lys Gln Cys Trp Glu Gly Glu Asp Leu 
                325                 330                 335     


Ser Lys Lys Thr Leu Leu Arg Phe Trp Leu Pro Phe Gly Phe Ile Leu 
            340                 345                 350         


Ile Leu Val Ile Phe Val Thr Gly Leu Leu Leu Arg Lys Pro Asn Thr 
        355                 360                 365             


Tyr Pro Lys Met Ile Pro Glu Phe Phe Cys Asp Thr 
    370                 375                 380 


<210> 17
<211> 551
<212> PRT
<213> Homo sapiens

<400> 17
Met Leu Pro Leu Leu Leu Leu Pro Leu Leu Trp Gly Gly Ser Leu Gln 
1               5                   10                  15      


Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg 
        35                  40                  45              


Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly 
    50                  55                  60                  


Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg 
65                  70                  75                  80  


Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val 
                85                  90                  95      


Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp 
            100                 105                 110         


Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr 
        115                 120                 125             


Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu 
    130                 135                 140                 


Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr 
145                 150                 155                 160 


Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu 
                165                 170                 175     


Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr 
            180                 185                 190         


Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly 
        195                 200                 205             


Thr Asn Leu Thr Cys Gln Met Lys Arg Gln Gly Ala Gln Val Thr Thr 
    210                 215                 220                 


Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Thr Ile Thr 
225                 230                 235                 240 


Ile Phe Arg Asn Gly Ile Ala Leu Glu Ile Leu Gln Asn Thr Ser Tyr 
                245                 250                 255     


Leu Pro Val Leu Glu Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Pro 
            260                 265                 270         


Ser Asn Pro Pro Ala His Leu Ser Trp Phe Gln Gly Ser Pro Ala Leu 
        275                 280                 285             


Asn Ala Thr Pro Ile Ser Asn Thr Gly Ile Leu Glu Leu Arg Arg Val 
    290                 295                 300                 


Arg Ser Ala Glu Glu Gly Gly Phe Thr Cys Arg Ala Gln His Pro Leu 
305                 310                 315                 320 


Gly Phe Leu Gln Ile Phe Leu Asn Leu Ser Val Tyr Ser Leu Pro Gln 
                325                 330                 335     


Leu Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Arg 
            340                 345                 350         


Cys Ser Phe Arg Ala Arg Pro Ala Pro Ser Leu Cys Trp Arg Leu Glu 
        355                 360                 365             


Glu Lys Pro Leu Glu Gly Asn Ser Ser Gln Gly Ser Phe Lys Val Asn 
    370                 375                 380                 


Ser Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ile Leu His Gly 
385                 390                 395                 400 


Gly Leu Ser Ser Asp Leu Lys Val Ser Cys Lys Ala Trp Asn Ile Tyr 
                405                 410                 415     


Gly Ser Gln Ser Gly Ser Val Leu Leu Leu Gln Gly Arg Ser Asn Leu 
            420                 425                 430         


Gly Thr Gly Val Val Pro Ala Ala Leu Gly Gly Ala Gly Val Met Ala 
        435                 440                 445             


Leu Leu Cys Ile Cys Leu Cys Leu Ile Phe Phe Leu Ile Val Lys Ala 
    450                 455                 460                 


Arg Arg Lys Gln Ala Ala Gly Arg Pro Glu Lys Met Asp Asp Glu Asp 
465                 470                 475                 480 


Pro Ile Met Gly Thr Ile Thr Ser Gly Ser Arg Lys Lys Pro Trp Pro 
                485                 490                 495     


Asp Ser Pro Gly Asp Gln Ala Ser Pro Pro Gly Asp Ala Pro Pro Leu 
            500                 505                 510         


Glu Glu Gln Lys Glu Leu His Tyr Ala Ser Leu Ser Phe Ser Glu Met 
        515                 520                 525             


Lys Ser Arg Glu Pro Lys Asp Gln Glu Ala Pro Ser Thr Thr Glu Tyr 
    530                 535                 540                 


Ser Glu Ile Lys Thr Ser Lys 
545                 550     


<210> 18
<211> 380
<212> PRT
<213> Homo sapiens

<400> 18
Met Glu Glu Gly Gly Asp Phe Asp Asn Tyr Tyr Gly Ala Asp Asn Gln 
1               5                   10                  15      


Ser Glu Cys Glu Tyr Thr Asp Trp Lys Ser Ser Gly Ala Leu Ile Pro 
            20                  25                  30          


Ala Ile Tyr Met Leu Val Phe Leu Leu Gly Thr Thr Gly Asn Gly Leu 
        35                  40                  45              


Val Leu Trp Thr Val Phe Arg Ser Ser Arg Glu Lys Arg Arg Ser Ala 
    50                  55                  60                  


Asp Ile Phe Ile Ala Ser Leu Ala Val Ala Asp Leu Thr Phe Val Val 
65                  70                  75                  80  


Thr Leu Pro Leu Trp Ala Thr Tyr Thr Tyr Arg Asp Tyr Asp Trp Pro 
                85                  90                  95      


Phe Gly Thr Phe Phe Cys Lys Leu Ser Ser Tyr Leu Ile Phe Val Asn 
            100                 105                 110         


Met Tyr Ala Ser Val Phe Cys Leu Thr Gly Leu Ser Phe Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Arg Pro Val Ala Asn Ala Arg Leu Arg Leu Arg Val 
    130                 135                 140                 


Ser Gly Ala Val Ala Thr Ala Val Leu Trp Val Leu Ala Ala Leu Leu 
145                 150                 155                 160 


Ala Met Pro Val Met Val Leu Arg Thr Thr Gly Asp Leu Glu Asn Thr 
                165                 170                 175     


Thr Lys Val Gln Cys Tyr Met Asp Tyr Ser Met Val Ala Thr Val Ser 
            180                 185                 190         


Ser Glu Trp Ala Trp Glu Val Gly Leu Gly Val Ser Ser Thr Thr Val 
        195                 200                 205             


Gly Phe Val Val Pro Phe Thr Ile Met Leu Thr Cys Tyr Phe Phe Ile 
    210                 215                 220                 


Ala Gln Thr Ile Ala Gly His Phe Arg Lys Glu Arg Ile Glu Gly Leu 
225                 230                 235                 240 


Arg Lys Arg Arg Arg Leu Leu Ser Ile Ile Val Val Leu Val Val Thr 
                245                 250                 255     


Phe Ala Leu Cys Trp Met Pro Tyr His Leu Val Lys Thr Leu Tyr Met 
            260                 265                 270         


Leu Gly Ser Leu Leu His Trp Pro Cys Asp Phe Asp Leu Phe Leu Met 
        275                 280                 285             


Asn Ile Phe Pro Tyr Cys Thr Cys Ile Ser Tyr Val Asn Ser Cys Leu 
    290                 295                 300                 


Asn Pro Phe Leu Tyr Ala Phe Phe Asp Pro Arg Phe Arg Gln Ala Cys 
305                 310                 315                 320 


Thr Ser Met Leu Cys Cys Gly Gln Ser Arg Cys Ala Gly Thr Ser His 
                325                 330                 335     


Ser Ser Ser Gly Glu Lys Ser Ala Ser Tyr Ser Ser Gly His Ser Gln 
            340                 345                 350         


Gly Pro Gly Pro Asn Met Gly Lys Gly Gly Glu Gln Met His Glu Lys 
        355                 360                 365             


Ser Ile Pro Tyr Ser Gln Glu Thr Leu Val Val Asp 
    370                 375                 380 


<210> 19
<211> 325
<212> PRT
<213> Homo sapiens

<400> 19
Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly Gly Gly Gly 
            20                  25                  30          


Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu 
        35                  40                  45              


Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val 
    50                  55                  60                  


Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg 
65                  70                  75                  80  


Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu 
                85                  90                  95      


Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr 
            100                 105                 110         


Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu 
        115                 120                 125             


Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu 
    130                 135                 140                 


Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu 
145                 150                 155                 160 


Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala 
                165                 170                 175     


Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg 
            180                 185                 190         


Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His 
        195                 200                 205             


His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg 
    210                 215                 220                 


Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr 
225                 230                 235                 240 


Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu 
                245                 250                 255     


His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys 
            260                 265                 270         


Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro 
        275                 280                 285             


Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro 
    290                 295                 300                 


Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His 
305                 310                 315                 320 


Thr Gln Arg Met Gln 
                325 


<210> 20
<211> 450
<212> PRT
<213> Homo sapiens

<400> 20
Met Gly Gly Met Lys Tyr Ile Phe Ser Leu Leu Phe Phe Leu Leu Leu 
1               5                   10                  15      


Glu Gly Gly Lys Thr Glu Gln Val Lys His Ser Glu Thr Tyr Cys Met 
            20                  25                  30          


Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu Arg Trp His Pro Tyr Leu 
        35                  40                  45              


Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn Cys Ile Cys Ser Glu Asn 
    50                  55                  60                  


Gly Asn Val Leu Cys Ser Arg Val Arg Cys Pro Asn Val His Cys Leu 
65                  70                  75                  80  


Ser Pro Val His Ile Pro His Leu Cys Cys Pro Arg Cys Pro Asp Ser 
                85                  90                  95      


Leu Pro Pro Val Asn Asn Lys Val Thr Ser Lys Ser Cys Glu Tyr Asn 
            100                 105                 110         


Gly Thr Thr Tyr Gln His Gly Glu Leu Phe Val Ala Glu Gly Leu Phe 
        115                 120                 125             


Gln Asn Arg Gln Pro Asn Gln Cys Thr Gln Cys Ser Cys Ser Glu Gly 
    130                 135                 140                 


Asn Val Tyr Cys Gly Leu Lys Thr Cys Pro Lys Leu Thr Cys Ala Phe 
145                 150                 155                 160 


Pro Val Ser Val Pro Asp Ser Cys Cys Arg Val Cys Arg Gly Asp Gly 
                165                 170                 175     


Glu Leu Ser Trp Glu His Ser Asp Gly Asp Ile Phe Arg Gln Pro Ala 
            180                 185                 190         


Asn Arg Glu Ala Arg His Ser Tyr His Arg Ser His Tyr Asp Pro Pro 
        195                 200                 205             


Pro Ser Arg Gln Ala Gly Gly Leu Ser Arg Phe Pro Gly Ala Arg Ser 
    210                 215                 220                 


His Arg Gly Ala Leu Met Asp Ser Gln Gln Ala Ser Gly Thr Ile Val 
225                 230                 235                 240 


Gln Ile Val Ile Asn Asn Lys His Lys His Gly Gln Val Cys Val Ser 
                245                 250                 255     


Asn Gly Lys Thr Tyr Ser His Gly Glu Ser Trp His Pro Asn Leu Arg 
            260                 265                 270         


Ala Phe Gly Ile Val Glu Cys Val Leu Cys Thr Cys Asn Val Thr Lys 
        275                 280                 285             


Gln Glu Cys Lys Lys Ile His Cys Pro Asn Arg Tyr Pro Cys Lys Tyr 
    290                 295                 300                 


Pro Gln Lys Ile Asp Gly Lys Cys Cys Lys Val Cys Pro Gly Lys Lys 
305                 310                 315                 320 


Ala Lys Glu Leu Pro Gly Gln Ser Phe Asp Asn Lys Gly Tyr Phe Cys 
                325                 330                 335     


Gly Glu Glu Thr Met Pro Val Tyr Glu Ser Val Phe Met Glu Asp Gly 
            340                 345                 350         


Glu Thr Thr Arg Lys Ile Ala Leu Glu Thr Glu Arg Pro Pro Gln Val 
        355                 360                 365             


Glu Val His Val Trp Thr Ile Arg Lys Gly Ile Leu Gln His Phe His 
    370                 375                 380                 


Ile Glu Lys Ile Ser Lys Arg Met Phe Glu Glu Leu Pro His Phe Lys 
385                 390                 395                 400 


Leu Val Thr Arg Thr Thr Leu Ser Gln Trp Lys Ile Phe Thr Glu Gly 
                405                 410                 415     


Glu Ala Gln Ile Ser Gln Met Cys Ser Ser Arg Val Cys Arg Thr Glu 
            420                 425                 430         


Leu Glu Asp Leu Val Lys Val Leu Tyr Leu Glu Arg Ser Glu Lys Gly 
        435                 440                 445             


His Cys 
    450 


<210> 21
<211> 576
<212> PRT
<213> Homo sapiens

<400> 21
Met Trp Ala Pro Arg Cys Arg Arg Phe Trp Ser Arg Trp Glu Gln Val 
1               5                   10                  15      


Ala Ala Leu Leu Leu Leu Leu Leu Leu Leu Gly Val Pro Pro Arg Ser 
            20                  25                  30          


Leu Ala Leu Pro Pro Ile Arg Tyr Ser His Ala Gly Ile Cys Pro Asn 
        35                  40                  45              


Asp Met Asn Pro Asn Leu Trp Val Asp Ala Gln Ser Thr Cys Arg Arg 
    50                  55                  60                  


Glu Cys Glu Thr Asp Gln Glu Cys Glu Thr Tyr Glu Lys Cys Cys Pro 
65                  70                  75                  80  


Asn Val Cys Gly Thr Lys Ser Cys Val Ala Ala Arg Tyr Met Asp Val 
                85                  90                  95      


Lys Gly Lys Lys Gly Pro Val Gly Met Pro Lys Glu Ala Thr Cys Asp 
            100                 105                 110         


His Phe Met Cys Leu Gln Gln Gly Ser Glu Cys Asp Ile Trp Asp Gly 
        115                 120                 125             


Gln Pro Val Cys Lys Cys Lys Asp Arg Cys Glu Lys Glu Pro Ser Phe 
    130                 135                 140                 


Thr Cys Ala Ser Asp Gly Leu Thr Tyr Tyr Asn Arg Cys Tyr Met Asp 
145                 150                 155                 160 


Ala Glu Ala Cys Ser Lys Gly Ile Thr Leu Ala Val Val Thr Cys Arg 
                165                 170                 175     


Tyr His Phe Thr Trp Pro Asn Thr Ser Pro Pro Pro Pro Glu Thr Thr 
            180                 185                 190         


Met His Pro Thr Thr Ala Ser Pro Glu Thr Pro Glu Leu Asp Met Ala 
        195                 200                 205             


Ala Pro Ala Leu Leu Asn Asn Pro Val His Gln Ser Val Thr Met Gly 
    210                 215                 220                 


Glu Thr Val Ser Phe Leu Cys Asp Val Val Gly Arg Pro Arg Pro Glu 
225                 230                 235                 240 


Ile Thr Trp Glu Lys Gln Leu Glu Asp Arg Glu Asn Val Val Met Arg 
                245                 250                 255     


Pro Asn His Val Arg Gly Asn Val Val Val Thr Asn Ile Ala Gln Leu 
            260                 265                 270         


Val Ile Tyr Asn Ala Gln Leu Gln Asp Ala Gly Ile Tyr Thr Cys Thr 
        275                 280                 285             


Ala Arg Asn Val Ala Gly Val Leu Arg Ala Asp Phe Pro Leu Ser Val 
    290                 295                 300                 


Val Arg Gly His Gln Ala Ala Ala Thr Ser Glu Ser Ser Pro Asn Gly 
305                 310                 315                 320 


Thr Ala Phe Pro Ala Ala Glu Cys Leu Lys Pro Pro Asp Ser Glu Asp 
                325                 330                 335     


Cys Gly Glu Glu Gln Thr Arg Trp His Phe Asp Ala Gln Ala Asn Asn 
            340                 345                 350         


Cys Leu Thr Phe Thr Phe Gly His Cys His Arg Asn Leu Asn His Phe 
        355                 360                 365             


Glu Thr Tyr Glu Ala Cys Met Leu Ala Cys Met Ser Gly Pro Leu Ala 
    370                 375                 380                 


Ala Cys Ser Leu Pro Ala Leu Gln Gly Pro Cys Lys Ala Tyr Ala Pro 
385                 390                 395                 400 


Arg Trp Ala Tyr Asn Ser Gln Thr Gly Gln Cys Gln Ser Phe Val Tyr 
                405                 410                 415     


Gly Gly Cys Glu Gly Asn Gly Asn Asn Phe Glu Ser Arg Glu Ala Cys 
            420                 425                 430         


Glu Glu Ser Cys Pro Phe Pro Arg Gly Asn Gln Arg Cys Arg Ala Cys 
        435                 440                 445             


Lys Pro Arg Gln Lys Leu Val Thr Ser Phe Cys Arg Ser Asp Phe Val 
    450                 455                 460                 


Ile Leu Gly Arg Val Ser Glu Leu Thr Glu Glu Pro Asp Ser Gly Arg 
465                 470                 475                 480 


Ala Leu Val Thr Val Asp Glu Val Leu Lys Asp Glu Lys Met Gly Leu 
                485                 490                 495     


Lys Phe Leu Gly Gln Glu Pro Leu Glu Val Thr Leu Leu His Val Asp 
            500                 505                 510         


Trp Ala Cys Pro Cys Pro Asn Val Thr Val Ser Glu Met Pro Leu Ile 
        515                 520                 525             


Ile Met Gly Glu Val Asp Gly Gly Met Ala Met Leu Arg Pro Asp Ser 
    530                 535                 540                 


Phe Val Gly Ala Ser Ser Ala Arg Arg Val Arg Lys Leu Arg Glu Val 
545                 550                 555                 560 


Met His Lys Lys Thr Cys Asp Val Leu Lys Glu Phe Leu Gly Leu His 
                565                 570                 575     


<210> 22
<211> 579
<212> PRT
<213> Homo sapiens

<400> 22
Met Lys Asp Phe Ser Asp Val Ile Leu Cys Met Glu Ala Thr Glu Ser 
1               5                   10                  15      


Ser Lys Thr Glu Phe Cys Asn Pro Ala Phe Glu Pro Glu Ser Gly Pro 
            20                  25                  30          


Pro Cys Pro Pro Pro Val Phe Pro Glu Asp Ala Ser Tyr Ser Val Pro 
        35                  40                  45              


Ala Pro Trp His Gly Arg Arg Pro Arg Gly Leu Arg Pro Asp Cys Arg 
    50                  55                  60                  


Phe Ser Trp Leu Cys Val Leu Leu Leu Ser Ser Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Gly Leu Leu Val Ala Ile Ile Leu Ala Gln Leu Gln Ala Ala Pro 
                85                  90                  95      


Pro Ser Gly Ala Ser His Ser Pro Leu Pro Ala Gly Gly Leu Thr Thr 
            100                 105                 110         


Thr Thr Thr Thr Pro Thr Ile Thr Thr Ser Gln Ala Ala Gly Thr Pro 
        115                 120                 125             


Lys Gly Gln Gln Glu Ser Gly Val Ser Pro Ser Pro Gln Ser Thr Cys 
    130                 135                 140                 


Gly Gly Leu Leu Ser Gly Pro Arg Gly Phe Phe Ser Ser Pro Asn Tyr 
145                 150                 155                 160 


Pro Asp Pro Tyr Pro Pro Asn Thr His Cys Val Trp His Ile Gln Val 
                165                 170                 175     


Ala Thr Asp His Ala Ile Gln Leu Lys Ile Glu Ala Leu Ser Ile Glu 
            180                 185                 190         


Ser Val Ala Ser Cys Leu Phe Asp Arg Leu Glu Leu Ser Pro Glu Pro 
        195                 200                 205             


Glu Gly Pro Leu Leu Arg Val Cys Gly Arg Val Pro Pro Pro Thr Leu 
    210                 215                 220                 


Asn Thr Asn Ala Ser His Leu Leu Val Val Phe Val Ser Asp Ser Ser 
225                 230                 235                 240 


Val Glu Gly Phe Gly Phe His Ala Trp Tyr Gln Ala Met Ala Pro Gly 
                245                 250                 255     


Arg Gly Ser Cys Ala His Asp Glu Phe Arg Cys Asp Gln Leu Ile Cys 
            260                 265                 270         


Leu Leu Pro Asp Ser Val Cys Asp Gly Phe Ala Asn Cys Ala Asp Gly 
        275                 280                 285             


Ser Asp Glu Thr Asn Cys Ser Ala Lys Phe Ser Gly Cys Gly Gly Asn 
    290                 295                 300                 


Leu Thr Gly Leu Gln Gly Thr Phe Ser Thr Pro Ser Tyr Leu Gln Gln 
305                 310                 315                 320 


Tyr Pro His Gln Leu Leu Cys Thr Trp His Ile Ser Val Pro Ala Gly 
                325                 330                 335     


His Ser Ile Glu Leu Gln Phe His Asn Phe Ser Leu Glu Ala Gln Asp 
            340                 345                 350         


Glu Cys Lys Phe Asp Tyr Val Glu Val Tyr Glu Thr Ser Ser Ser Gly 
        355                 360                 365             


Ala Phe Ser Leu Leu Gly Arg Phe Cys Gly Ala Glu Pro Pro Pro His 
    370                 375                 380                 


Leu Val Ser Ser His His Glu Leu Ala Val Leu Phe Arg Thr Asp His 
385                 390                 395                 400 


Gly Ile Ser Ser Gly Gly Phe Ser Ala Thr Tyr Leu Ala Phe Asn Ala 
                405                 410                 415     


Thr Glu Asn Pro Cys Gly Pro Ser Glu Leu Ser Cys Gln Ala Gly Gly 
            420                 425                 430         


Cys Lys Gly Val Gln Trp Met Cys Asp Met Trp Arg Asp Cys Thr Asp 
        435                 440                 445             


Gly Ser Asp Asp Asn Cys Ser Gly Pro Leu Phe Pro Pro Pro Glu Leu 
    450                 455                 460                 


Ala Cys Glu Pro Val Gln Val Glu Met Cys Leu Gly Leu Ser Tyr Asn 
465                 470                 475                 480 


Thr Thr Ala Phe Pro Asn Ile Trp Val Gly Met Ile Thr Gln Glu Glu 
                485                 490                 495     


Val Val Glu Val Leu Ser Gly Tyr Lys Ser Leu Thr Ser Leu Pro Cys 
            500                 505                 510         


Tyr Gln His Phe Arg Arg Leu Leu Cys Gly Leu Leu Val Pro Arg Cys 
        515                 520                 525             


Thr Pro Leu Gly Ser Val Leu Pro Pro Cys Arg Ser Val Cys Gln Glu 
    530                 535                 540                 


Ala Glu His Gln Cys Gln Ser Gly Leu Ala Leu Leu Gly Thr Pro Trp 
545                 550                 555                 560 


Pro Phe Asn Cys Asn Arg Leu Pro Glu Ala Ala Asp Leu Glu Ala Cys 
                565                 570                 575     


Ala Gln Pro 
            


<210> 23
<211> 578
<212> PRT
<213> Homo sapiens

<400> 23
Met Leu Pro Cys Leu Val Val Leu Leu Ala Ala Leu Leu Ser Leu Arg 
1               5                   10                  15      


Leu Gly Ser Asp Ala His Gly Thr Glu Leu Pro Ser Pro Pro Ser Val 
            20                  25                  30          


Trp Phe Glu Ala Glu Phe Phe His His Ile Leu His Trp Thr Pro Ile 
        35                  40                  45              


Pro Asn Gln Ser Glu Ser Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr 
    50                  55                  60                  


Gly Ile Glu Ser Trp Asn Ser Ile Ser Asn Cys Ser Gln Thr Leu Ser 
65                  70                  75                  80  


Tyr Asp Leu Thr Ala Val Thr Leu Asp Leu Tyr His Ser Asn Gly Tyr 
                85                  90                  95      


Arg Ala Arg Val Arg Ala Val Asp Gly Ser Arg His Ser Asn Trp Thr 
            100                 105                 110         


Val Thr Asn Thr Arg Phe Ser Val Asp Glu Val Thr Leu Thr Val Gly 
        115                 120                 125             


Ser Val Asn Leu Glu Ile His Asn Gly Phe Ile Leu Gly Lys Ile Gln 
    130                 135                 140                 


Leu Pro Arg Pro Lys Met Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile 
145                 150                 155                 160 


Phe Ser His Phe Arg Glu Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly 
                165                 170                 175     


Asn Phe Thr Phe Thr His Lys Lys Val Lys His Glu Asn Phe Ser Leu 
            180                 185                 190         


Leu Thr Ser Gly Glu Val Gly Glu Phe Cys Val Gln Val Lys Pro Ser 
        195                 200                 205             


Val Ala Ser Arg Ser Asn Lys Gly Met Trp Ser Lys Glu Glu Cys Ile 
    210                 215                 220                 


Ser Leu Thr Arg Gln Tyr Phe Thr Val Thr Asn Val Ile Ile Phe Phe 
225                 230                 235                 240 


Ala Phe Val Leu Leu Leu Ser Gly Ala Leu Ala Tyr Cys Leu Ala Leu 
                245                 250                 255     


Gln Leu Tyr Val Arg Arg Arg Lys Lys Leu Pro Ser Val Leu Leu Phe 
            260                 265                 270         


Lys Lys Pro Ser Pro Phe Ile Phe Ile Ser Gln Arg Pro Ser Pro Glu 
        275                 280                 285             


Thr Gln Asp Thr Ile His Pro Leu Asp Glu Glu Ala Phe Leu Lys Val 
    290                 295                 300                 


Ser Pro Glu Leu Lys Asn Leu Asp Leu His Gly Ser Thr Asp Ser Gly 
305                 310                 315                 320 


Phe Gly Ser Thr Lys Pro Ser Leu Gln Thr Glu Glu Pro Gln Phe Leu 
                325                 330                 335     


Leu Pro Asp Pro His Pro Gln Ala Asp Arg Thr Leu Gly Asn Arg Glu 
            340                 345                 350         


Pro Pro Val Leu Gly Asp Ser Cys Ser Ser Gly Ser Ser Asn Ser Thr 
        355                 360                 365             


Asp Ser Gly Ile Cys Leu Gln Glu Pro Ser Leu Ser Pro Ser Thr Gly 
    370                 375                 380                 


Pro Thr Trp Glu Gln Gln Val Gly Ser Asn Ser Arg Gly Gln Asp Asp 
385                 390                 395                 400 


Ser Gly Ile Asp Leu Val Gln Asn Ser Glu Gly Arg Ala Gly Asp Thr 
                405                 410                 415     


Gln Gly Gly Ser Ala Leu Gly His His Ser Pro Pro Glu Pro Glu Val 
            420                 425                 430         


Pro Gly Glu Glu Asp Pro Ala Ala Val Ala Phe Gln Gly Tyr Leu Arg 
        435                 440                 445             


Gln Thr Arg Cys Ala Glu Glu Lys Ala Thr Lys Thr Gly Cys Leu Glu 
    450                 455                 460                 


Glu Glu Ser Pro Leu Thr Asp Gly Leu Gly Pro Lys Phe Gly Arg Cys 
465                 470                 475                 480 


Leu Val Asp Glu Ala Gly Leu His Pro Pro Ala Leu Ala Lys Gly Tyr 
                485                 490                 495     


Leu Lys Gln Asp Pro Leu Glu Met Thr Leu Ala Ser Ser Gly Ala Pro 
            500                 505                 510         


Thr Gly Gln Trp Asn Gln Pro Thr Glu Glu Trp Ser Leu Leu Ala Leu 
        515                 520                 525             


Ser Ser Cys Ser Asp Leu Gly Ile Ser Asp Trp Ser Phe Ala His Asp 
    530                 535                 540                 


Leu Ala Pro Leu Gly Cys Val Ala Ala Pro Gly Gly Leu Leu Gly Ser 
545                 550                 555                 560 


Phe Asn Ser Asp Leu Val Thr Leu Pro Leu Ile Ser Ser Leu Gln Ser 
                565                 570                 575     


Ser Glu 
        


<210> 24
<211> 373
<212> PRT
<213> Homo sapiens

<400> 24
Met Arg Met Glu Asp Glu Asp Tyr Asn Thr Ser Ile Ser Tyr Gly Asp 
1               5                   10                  15      


Glu Tyr Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser 
            20                  25                  30          


Pro Leu Glu Ala Arg Val Thr Arg Ile Phe Leu Val Val Val Tyr Ser 
        35                  40                  45              


Ile Val Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile 
    50                  55                  60                  


Ala Thr Phe Lys Met Lys Lys Thr Val Asn Met Val Trp Phe Leu Asn 
65                  70                  75                  80  


Leu Ala Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile 
                85                  90                  95      


Thr Tyr Ala Ala Met Asp Tyr His Trp Val Phe Gly Thr Ala Met Cys 
            100                 105                 110         


Lys Ile Ser Asn Phe Leu Leu Ile His Asn Met Phe Thr Ser Val Phe 
        115                 120                 125             


Leu Leu Thr Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro 
    130                 135                 140                 


Val Trp Ser Gln Asn His Arg Ser Val Arg Leu Ala Tyr Met Ala Cys 
145                 150                 155                 160 


Met Val Ile Trp Val Leu Ala Phe Phe Leu Ser Ser Pro Ser Leu Val 
                165                 170                 175     


Phe Arg Asp Thr Ala Asn Leu His Gly Lys Ile Ser Cys Phe Asn Asn 
            180                 185                 190         


Phe Ser Leu Ser Thr Pro Gly Ser Ser Ser Trp Pro Thr His Ser Gln 
        195                 200                 205             


Met Asp Pro Val Gly Tyr Ser Arg His Met Val Val Thr Val Thr Arg 
    210                 215                 220                 


Phe Leu Cys Gly Phe Leu Val Pro Val Leu Ile Ile Thr Ala Cys Tyr 
225                 230                 235                 240 


Leu Thr Ile Val Cys Lys Leu Gln Arg Asn Arg Leu Ala Lys Thr Lys 
                245                 250                 255     


Lys Pro Phe Lys Ile Ile Val Thr Ile Ile Ile Thr Phe Phe Leu Cys 
            260                 265                 270         


Trp Cys Pro Tyr His Thr Leu Asn Leu Leu Glu Leu His His Thr Ala 
        275                 280                 285             


Met Pro Gly Ser Val Phe Ser Leu Gly Leu Pro Leu Ala Thr Ala Leu 
    290                 295                 300                 


Ala Ile Ala Asn Ser Cys Met Asn Pro Ile Leu Tyr Val Phe Met Gly 
305                 310                 315                 320 


Gln Asp Phe Lys Lys Phe Lys Val Ala Leu Phe Ser Arg Leu Val Asn 
                325                 330                 335     


Ala Leu Ser Glu Asp Thr Gly His Ser Ser Tyr Pro Ser His Arg Ser 
            340                 345                 350         


Phe Thr Lys Met Ser Ser Met Asn Glu Arg Thr Ser Met Asn Glu Arg 
        355                 360                 365             


Glu Thr Gly Met Leu 
    370             


<210> 25
<211> 208
<212> PRT
<213> Homo sapiens

<400> 25
Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val 
1               5                   10                  15      


Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
            20                  25                  30          


Leu Ala Ala Gly Thr Ser Asn Pro Asp Pro Pro Thr Val Ser Thr Asp 
        35                  40                  45              


Gln Leu Leu Pro Leu Gly Gly Gly Arg Asp Arg Lys Val Arg Asp Leu 
    50                  55                  60                  


Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser Lys Pro 
65                  70                  75                  80  


Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg Lys Lys 
                85                  90                  95      


Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr 
            100                 105                 110         


Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu Arg 
        115                 120                 125             


Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys His 
    130                 135                 140                 


Gly Leu Ser Leu Pro Val Glu Asn Arg Leu Tyr Thr Tyr Asp His Thr 
145                 150                 155                 160 


Thr Ile Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                165                 170                 175     


Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
            180                 185                 190         


Asp Val Glu Asn Glu Glu Lys Val Lys Leu Gly Met Thr Asn Ser His 
        195                 200                 205             


<210> 26
<211> 208
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Leu Gly Gln Lys Leu Phe Ile Thr Met Ser Arg Gly Ala Gly 
1               5                   10                  15      


Arg Leu Gln Gly Thr Leu Trp Ala Leu Val Phe Leu Gly Ile Leu Val 
            20                  25                  30          


Gly Met Val Val Pro Ser Pro Ala Gly Thr Arg Ala Asn Asn Thr Leu 
        35                  40                  45              


Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly 
    50                  55                  60                  


Leu Ala Gly Glu Ile Ala Gly Val Asn Trp Glu Ser Gly Tyr Leu Val 
65                  70                  75                  80  


Gly Ile Lys Arg Gln Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe 
                85                  90                  95      


His Leu Gln Val Leu Pro Asp Gly Arg Ile Ser Gly Thr His Glu Glu 
            100                 105                 110         


Asn Pro Tyr Ser Leu Leu Glu Ile Ser Thr Val Glu Arg Gly Val Val 
        115                 120                 125             


Ser Leu Phe Gly Val Arg Ser Ala Leu Phe Val Ala Met Asn Ser Lys 
    130                 135                 140                 


Gly Arg Leu Tyr Ala Thr Pro Ser Phe Gln Glu Glu Cys Lys Phe Arg 
145                 150                 155                 160 


Glu Thr Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Asp Leu Tyr 
                165                 170                 175     


Gln Gly Thr Tyr Ile Ala Leu Ser Lys Tyr Gly Arg Val Lys Arg Gly 
            180                 185                 190         


Ser Lys Val Ser Pro Ile Met Thr Val Thr His Phe Leu Pro Arg Ile 
        195                 200                 205             


<210> 27
<211> 1390
<212> PRT
<213> Homo sapiens

<400> 27
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
    930                 935                 940                 


Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
945                 950                 955                 960 


Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                965                 970                 975     


Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
            980                 985                 990         


Thr Glu Met Val Ser Asn Glu Ser  Val Asp Tyr Arg Ala  Thr Phe Pro 
        995                 1000                 1005             


Glu Asp  Gln Phe Pro Asn Ser  Ser Gln Asn Gly Ser  Cys Arg Gln 
    1010                 1015                 1020             


Val Gln  Tyr Pro Leu Thr Asp  Met Ser Pro Ile Leu  Thr Ser Gly 
    1025                 1030                 1035             


Asp Ser  Asp Ile Ser Ser Pro  Leu Leu Gln Asn Thr  Val His Ile 
    1040                 1045                 1050             


Asp Leu  Ser Ala Leu Asn Pro  Glu Leu Val Gln Ala  Val Gln His 
    1055                 1060                 1065             


Val Val  Ile Gly Pro Ser Ser  Leu Ile Val His Phe  Asn Glu Val 
    1070                 1075                 1080             


Ile Gly  Arg Gly His Phe Gly  Cys Val Tyr His Gly  Thr Leu Leu 
    1085                 1090                 1095             


Asp Asn  Asp Gly Lys Lys Ile  His Cys Ala Val Lys  Ser Leu Asn 
    1100                 1105                 1110             


Arg Ile  Thr Asp Ile Gly Glu  Val Ser Gln Phe Leu  Thr Glu Gly 
    1115                 1120                 1125             


Ile Ile  Met Lys Asp Phe Ser  His Pro Asn Val Leu  Ser Leu Leu 
    1130                 1135                 1140             


Gly Ile  Cys Leu Arg Ser Glu  Gly Ser Pro Leu Val  Val Leu Pro 
    1145                 1150                 1155             


Tyr Met  Lys His Gly Asp Leu  Arg Asn Phe Ile Arg  Asn Glu Thr 
    1160                 1165                 1170             


His Asn  Pro Thr Val Lys Asp  Leu Ile Gly Phe Gly  Leu Gln Val 
    1175                 1180                 1185             


Ala Lys  Gly Met Lys Tyr Leu  Ala Ser Lys Lys Phe  Val His Arg 
    1190                 1195                 1200             


Asp Leu  Ala Ala Arg Asn Cys  Met Leu Asp Glu Lys  Phe Thr Val 
    1205                 1210                 1215             


Lys Val  Ala Asp Phe Gly Leu  Ala Arg Asp Met Tyr  Asp Lys Glu 
    1220                 1225                 1230             


Tyr Tyr  Ser Val His Asn Lys  Thr Gly Ala Lys Leu  Pro Val Lys 
    1235                 1240                 1245             


Trp Met  Ala Leu Glu Ser Leu  Gln Thr Gln Lys Phe  Thr Thr Lys 
    1250                 1255                 1260             


Ser Asp  Val Trp Ser Phe Gly  Val Leu Leu Trp Glu  Leu Met Thr 
    1265                 1270                 1275             


Arg Gly  Ala Pro Pro Tyr Pro  Asp Val Asn Thr Phe  Asp Ile Thr 
    1280                 1285                 1290             


Val Tyr  Leu Leu Gln Gly Arg  Arg Leu Leu Gln Pro  Glu Tyr Cys 
    1295                 1300                 1305             


Pro Asp  Pro Leu Tyr Glu Val  Met Leu Lys Cys Trp  His Pro Lys 
    1310                 1315                 1320             


Ala Glu  Met Arg Pro Ser Phe  Ser Glu Leu Val Ser  Arg Ile Ser 
    1325                 1330                 1335             


Ala Ile  Phe Ser Thr Phe Ile  Gly Glu His Tyr Val  His Val Asn 
    1340                 1345                 1350             


Ala Thr  Tyr Val Asn Val Lys  Cys Val Ala Pro Tyr  Pro Ser Leu 
    1355                 1360                 1365             


Leu Ser  Ser Glu Asp Asn Ala  Asp Asp Glu Val Asp  Thr Arg Pro 
    1370                 1375                 1380             


Ala Ser  Phe Trp Glu Thr Ser  
    1385                 1390 


<210> 28
<211> 1332
<212> PRT
<213> Homo sapiens

<400> 28
Met Glu Ser His Ser Arg Ala Gly Lys Ser Arg Lys Ser Ala Lys Phe 
1               5                   10                  15      


Arg Ser Ile Ser Arg Ser Leu Met Leu Cys Asn Ala Lys Thr Ser Asp 
            20                  25                  30          


Asp Gly Ser Ser Pro Asp Glu Lys Tyr Pro Asp Pro Phe Glu Ile Ser 
        35                  40                  45              


Leu Ala Gln Gly Lys Glu Gly Ile Phe His Ser Ser Val Gln Leu Ala 
    50                  55                  60                  


Asp Thr Ser Glu Ala Gly Pro Ser Ser Val Pro Asp Leu Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Ala Ala Gln Leu Gln Ala Ala Gly Asn Asp Arg Gly Lys Thr 
                85                  90                  95      


Cys Arg Arg Ile Phe Phe Met Lys Glu Ser Ser Thr Ala Ser Ser Arg 
            100                 105                 110         


Glu Lys Pro Gly Lys Leu Glu Ala Gln Ser Ser Asn Phe Leu Phe Pro 
        115                 120                 125             


Lys Ala Cys His Gln Arg Ala Arg Ser Asn Ser Thr Ser Val Asn Pro 
    130                 135                 140                 


Tyr Cys Thr Arg Glu Ile Asp Phe Pro Met Thr Lys Lys Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Asp Arg Gln Pro Tyr Ser Leu Cys Ser Asn Arg Lys Ser Leu 
                165                 170                 175     


Ser Gln Gln Leu Asp Cys Pro Ala Gly Lys Ala Ala Gly Thr Ser Arg 
            180                 185                 190         


Pro Thr Arg Ser Leu Ser Thr Ala Gln Leu Val Gln Pro Ser Gly Gly 
        195                 200                 205             


Leu Gln Ala Ser Val Ile Ser Asn Ile Val Leu Met Lys Gly Gln Ala 
    210                 215                 220                 


Lys Gly Leu Gly Phe Ser Ile Val Gly Gly Lys Asp Ser Ile Tyr Gly 
225                 230                 235                 240 


Pro Ile Gly Ile Tyr Val Lys Thr Ile Phe Ala Gly Gly Ala Ala Ala 
                245                 250                 255     


Ala Asp Gly Arg Leu Gln Glu Gly Asp Glu Ile Leu Glu Leu Asn Gly 
            260                 265                 270         


Glu Ser Met Ala Gly Leu Thr His Gln Asp Ala Leu Gln Lys Phe Lys 
        275                 280                 285             


Gln Ala Lys Lys Gly Leu Leu Thr Leu Thr Val Arg Thr Arg Leu Thr 
    290                 295                 300                 


Ala Pro Pro Ser Leu Cys Ser His Leu Ser Pro Pro Leu Cys Arg Ser 
305                 310                 315                 320 


Leu Ser Ser Ser Thr Cys Ile Thr Lys Asp Ser Ser Ser Phe Ala Leu 
                325                 330                 335     


Glu Ser Pro Ser Ala Pro Ile Ser Thr Ala Lys Pro Asn Tyr Arg Ile 
            340                 345                 350         


Met Val Glu Val Ser Leu Gln Lys Glu Ala Gly Val Gly Leu Gly Ile 
        355                 360                 365             


Gly Leu Cys Ser Val Pro Tyr Phe Gln Cys Ile Ser Gly Ile Phe Val 
    370                 375                 380                 


His Thr Leu Ser Pro Gly Ser Val Ala His Leu Asp Gly Arg Leu Arg 
385                 390                 395                 400 


Cys Gly Asp Glu Ile Val Glu Ile Ser Asp Ser Pro Val His Cys Leu 
                405                 410                 415     


Thr Leu Asn Glu Val Tyr Thr Ile Leu Ser His Cys Asp Pro Gly Pro 
            420                 425                 430         


Val Pro Ile Ile Val Ser Arg His Pro Asp Pro Gln Val Ser Glu Gln 
        435                 440                 445             


Gln Leu Lys Glu Ala Val Ala Gln Ala Val Glu Asn Thr Lys Phe Gly 
    450                 455                 460                 


Lys Glu Arg His Gln Trp Ser Leu Glu Gly Val Lys Arg Leu Glu Ser 
465                 470                 475                 480 


Ser Trp His Gly Arg Pro Thr Leu Glu Lys Glu Arg Glu Lys Asn Ser 
                485                 490                 495     


Ala Pro Pro His Arg Arg Ala Gln Lys Val Met Ile Arg Ser Ser Ser 
            500                 505                 510         


Asp Ser Ser Tyr Met Ser Gly Ser Pro Gly Gly Ser Pro Gly Ser Gly 
        515                 520                 525             


Ser Ala Glu Lys Pro Ser Ser Asp Val Asp Ile Ser Thr His Ser Pro 
    530                 535                 540                 


Ser Leu Pro Leu Ala Arg Glu Pro Val Val Leu Ser Ile Ala Ser Ser 
545                 550                 555                 560 


Arg Leu Pro Gln Glu Ser Pro Pro Leu Pro Glu Ser Arg Asp Ser His 
                565                 570                 575     


Pro Pro Leu Arg Leu Lys Lys Ser Phe Glu Ile Leu Val Arg Lys Pro 
            580                 585                 590         


Met Ser Ser Lys Pro Lys Pro Pro Pro Arg Lys Tyr Phe Lys Ser Asp 
        595                 600                 605             


Ser Asp Pro Gln Lys Ser Leu Glu Glu Arg Glu Asn Ser Ser Cys Ser 
    610                 615                 620                 


Ser Gly His Thr Pro Pro Thr Cys Gly Gln Glu Ala Arg Glu Leu Leu 
625                 630                 635                 640 


Pro Leu Leu Leu Pro Gln Glu Asp Thr Ala Gly Arg Ser Pro Ser Ala 
                645                 650                 655     


Ser Ala Gly Cys Pro Gly Pro Gly Ile Gly Pro Gln Thr Lys Ser Ser 
            660                 665                 670         


Thr Glu Gly Glu Pro Gly Trp Arg Arg Ala Ser Pro Val Thr Gln Thr 
        675                 680                 685             


Ser Pro Ile Lys His Pro Leu Leu Lys Arg Gln Ala Arg Met Asp Tyr 
    690                 695                 700                 


Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile Ser Asp Cys 
705                 710                 715                 720 


Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His Gly His Met 
                725                 730                 735     


Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly Thr Gln Gly 
            740                 745                 750         


His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn Gly Thr Pro 
        755                 760                 765             


Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys Gly Pro Pro 
    770                 775                 780                 


Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys Gly Leu Arg 
785                 790                 795                 800 


Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala Leu Ser Thr 
                805                 810                 815     


Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His Ile Arg Ala 
            820                 825                 830         


Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser Phe Glu Thr 
        835                 840                 845             


Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg Leu Ser Leu 
    850                 855                 860                 


Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys His Glu Glu 
865                 870                 875                 880 


Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro Thr Leu Val 
                885                 890                 895     


Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro Ala Ala Ser 
            900                 905                 910         


Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro Gly Arg Gln 
        915                 920                 925             


Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu Leu Arg Leu 
    930                 935                 940                 


Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu Lys Met Pro 
945                 950                 955                 960 


Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln Ser Cys Glu 
                965                 970                 975     


Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser Ile Ser Ser 
            980                 985                 990         


Gln Val Ser Ser Ala Val Met Lys  Ser Leu Leu Cys Leu  Pro Ser Ser 
        995                 1000                 1005             


Ile Ser  Cys Ala Gln Thr Pro  Cys Ile Pro Lys Glu  Gly Ala Ser 
    1010                 1015                 1020             


Pro Thr  Ser Ser Ser Asn Glu  Asp Ser Ala Ala Asn  Gly Ser Ala 
    1025                 1030                 1035             


Glu Thr  Ser Ala Leu Asp Thr  Gly Phe Ser Leu Asn  Leu Ser Glu 
    1040                 1045                 1050             


Leu Arg  Glu Tyr Thr Glu Gly  Leu Thr Glu Ala Lys  Glu Asp Asp 
    1055                 1060                 1065             


Asp Gly  Asp His Ser Ser Leu  Gln Ser Gly Gln Ser  Val Ile Ser 
    1070                 1075                 1080             


Leu Leu  Ser Ser Glu Glu Leu  Lys Lys Leu Ile Glu  Glu Val Lys 
    1085                 1090                 1095             


Val Leu  Asp Glu Ala Thr Leu  Lys Gln Leu Asp Gly  Ile His Val 
    1100                 1105                 1110             


Thr Ile  Leu His Lys Glu Glu  Gly Ala Gly Leu Gly  Phe Ser Leu 
    1115                 1120                 1125             


Ala Gly  Gly Ala Asp Leu Glu  Asn Lys Val Ile Thr  Val His Arg 
    1130                 1135                 1140             


Val Phe  Pro Asn Gly Leu Ala  Ser Gln Glu Gly Thr  Ile Gln Lys 
    1145                 1150                 1155             


Gly Asn  Glu Val Leu Ser Ile  Asn Gly Lys Ser Leu  Lys Gly Thr 
    1160                 1165                 1170             


Thr His  His Asp Ala Leu Ala  Ile Leu Arg Gln Ala  Arg Glu Pro 
    1175                 1180                 1185             


Arg Gln  Ala Val Ile Val Thr  Arg Lys Leu Thr Pro  Glu Ala Met 
    1190                 1195                 1200             


Pro Asp  Leu Asn Ser Ser Thr  Asp Ser Ala Ala Ser  Ala Ser Ala 
    1205                 1210                 1215             


Ala Ser  Asp Val Ser Val Glu  Ser Thr Ala Glu Ala  Thr Val Cys 
    1220                 1225                 1230             


Thr Val  Thr Leu Glu Lys Met  Ser Ala Gly Leu Gly  Phe Ser Leu 
    1235                 1240                 1245             


Glu Gly  Gly Lys Gly Ser Leu  His Gly Asp Lys Pro  Leu Thr Ile 
    1250                 1255                 1260             


Asn Arg  Ile Phe Lys Gly Ala  Ala Ser Glu Gln Ser  Glu Thr Val 
    1265                 1270                 1275             


Gln Pro  Gly Asp Glu Ile Leu  Gln Leu Gly Gly Thr  Ala Met Gln 
    1280                 1285                 1290             


Gly Leu  Thr Arg Phe Glu Ala  Trp Asn Ile Ile Lys  Ala Leu Pro 
    1295                 1300                 1305             


Asp Gly  Pro Val Thr Ile Val  Ile Arg Arg Lys Ser  Leu Gln Ser 
    1310                 1315                 1320             


Lys Glu  Thr Thr Ala Ala Gly  Asp Ser 
    1325                 1330         


<210> 29
<211> 459
<212> PRT
<213> Homo sapiens

<400> 29
Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210> 30
<211> 259
<212> PRT
<213> Homo sapiens

<400> 30
Met Ala Arg Ile Pro Lys Thr Leu Lys Phe Val Val Val Ile Val Ala 
1               5                   10                  15      


Val Leu Leu Pro Val Leu Ala Tyr Ser Ala Thr Thr Ala Arg Gln Glu 
            20                  25                  30          


Glu Val Pro Gln Gln Thr Val Ala Pro Gln Gln Gln Arg His Ser Phe 
        35                  40                  45              


Lys Gly Glu Glu Cys Pro Ala Gly Ser His Arg Ser Glu His Thr Gly 
    50                  55                  60                  


Ala Cys Asn Pro Cys Thr Glu Gly Val Asp Tyr Thr Asn Ala Ser Asn 
65                  70                  75                  80  


Asn Glu Pro Ser Cys Phe Pro Cys Thr Val Cys Lys Ser Asp Gln Lys 
                85                  90                  95      


His Lys Ser Ser Cys Thr Met Thr Arg Asp Thr Val Cys Gln Cys Lys 
            100                 105                 110         


Glu Gly Thr Phe Arg Asn Glu Asn Ser Pro Glu Met Cys Arg Lys Cys 
        115                 120                 125             


Ser Arg Cys Pro Ser Gly Glu Val Gln Val Ser Asn Cys Thr Ser Trp 
    130                 135                 140                 


Asp Asp Ile Gln Cys Val Glu Glu Phe Gly Ala Asn Ala Thr Val Glu 
145                 150                 155                 160 


Thr Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala 
                165                 170                 175     


Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala Pro 
            180                 185                 190         


Ala Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala 
        195                 200                 205             


Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala Ala 
    210                 215                 220                 


Glu Glu Thr Met Ile Thr Ser Pro Gly Thr Pro Ala Ser Ser His Tyr 
225                 230                 235                 240 


Leu Ser Cys Thr Ile Val Gly Ile Ile Val Leu Ile Val Leu Leu Ile 
                245                 250                 255     


Val Phe Val 
            


<210> 31
<211> 513
<212> PRT
<213> Homo sapiens

<400> 31
Met Pro Gly Leu Gly Arg Arg Ala Gln Trp Leu Cys Trp Trp Trp Gly 
1               5                   10                  15      


Leu Leu Cys Ser Cys Cys Gly Pro Pro Pro Leu Arg Pro Pro Leu Pro 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Leu Leu Gly Asp Gly Gly 
        35                  40                  45              


Ser Pro Gly Arg Thr Glu Gln Pro Pro Pro Ser Pro Gln Ser Ser Ser 
    50                  55                  60                  


Gly Phe Leu Tyr Arg Arg Leu Lys Thr Gln Glu Lys Arg Glu Met Gln 
65                  70                  75                  80  


Lys Glu Ile Leu Ser Val Leu Gly Leu Pro His Arg Pro Arg Pro Leu 
                85                  90                  95      


His Gly Leu Gln Gln Pro Gln Pro Pro Ala Leu Arg Gln Gln Glu Glu 
            100                 105                 110         


Gln Gln Gln Gln Gln Gln Leu Pro Arg Gly Glu Pro Pro Pro Gly Arg 
        115                 120                 125             


Leu Lys Ser Ala Pro Leu Phe Met Leu Asp Leu Tyr Asn Ala Leu Ser 
    130                 135                 140                 


Ala Asp Asn Asp Glu Asp Gly Ala Ser Glu Gly Glu Arg Gln Gln Ser 
145                 150                 155                 160 


Trp Pro His Glu Ala Ala Ser Ser Ser Gln Arg Arg Gln Pro Pro Pro 
                165                 170                 175     


Gly Ala Ala His Pro Leu Asn Arg Lys Ser Leu Leu Ala Pro Gly Ser 
            180                 185                 190         


Gly Ser Gly Gly Ala Ser Pro Leu Thr Ser Ala Gln Asp Ser Ala Phe 
        195                 200                 205             


Leu Asn Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu Tyr 
    210                 215                 220                 


Asp Lys Glu Phe Ser Pro Arg Gln Arg His His Lys Glu Phe Lys Phe 
225                 230                 235                 240 


Asn Leu Ser Gln Ile Pro Glu Gly Glu Val Val Thr Ala Ala Glu Phe 
                245                 250                 255     


Arg Ile Tyr Lys Asp Cys Val Met Gly Ser Phe Lys Asn Gln Thr Phe 
            260                 265                 270         


Leu Ile Ser Ile Tyr Gln Val Leu Gln Glu His Gln His Arg Asp Ser 
        275                 280                 285             


Asp Leu Phe Leu Leu Asp Thr Arg Val Val Trp Ala Ser Glu Glu Gly 
    290                 295                 300                 


Trp Leu Glu Phe Asp Ile Thr Ala Thr Ser Asn Leu Trp Val Val Thr 
305                 310                 315                 320 


Pro Gln His Asn Met Gly Leu Gln Leu Ser Val Val Thr Arg Asp Gly 
                325                 330                 335     


Val His Val His Pro Arg Ala Ala Gly Leu Val Gly Arg Asp Gly Pro 
            340                 345                 350         


Tyr Asp Lys Gln Pro Phe Met Val Ala Phe Phe Lys Val Ser Glu Val 
        355                 360                 365             


His Val Arg Thr Thr Arg Ser Ala Ser Ser Arg Arg Arg Gln Gln Ser 
    370                 375                 380                 


Arg Asn Arg Ser Thr Gln Ser Gln Asp Val Ala Arg Val Ser Ser Ala 
385                 390                 395                 400 


Ser Asp Tyr Asn Ser Ser Glu Leu Lys Thr Ala Cys Arg Lys His Glu 
                405                 410                 415     


Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala 
            420                 425                 430         


Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly Glu Cys Ser Phe Pro 
        435                 440                 445             


Leu Asn Ala His Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu 
    450                 455                 460                 


Val His Leu Met Asn Pro Glu Tyr Val Pro Lys Pro Cys Cys Ala Pro 
465                 470                 475                 480 


Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Asn Ser Asn 
                485                 490                 495     


Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys 
            500                 505                 510         


His 
    


<210> 32
<211> 169
<212> PRT
<213> Homo sapiens

<400> 32
Met Arg Gly Thr Pro Gly Asp Ala Asp Gly Gly Gly Arg Ala Val Tyr 
1               5                   10                  15      


Gln Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln 
            20                  25                  30          


Gln Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg Ser 
        35                  40                  45              


Asp Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro 
    50                  55                  60                  


Glu Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile Gln 
65                  70                  75                  80  


Asn Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro Thr 
                85                  90                  95      


Leu Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu 
            100                 105                 110         


Pro Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr Ser 
        115                 120                 125             


Thr Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser Lys 
    130                 135                 140                 


Arg Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn 
145                 150                 155                 160 


Thr Ala Phe Glu Leu Asn Ile Asn Asp 
                165                 


<210> 33
<211> 177
<212> PRT
<213> Homo sapiens

<400> 33
Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu 
    


<210> 34
<211> 462
<212> PRT
<213> Homo sapiens

<400> 34
Met Gly Thr Gln Ala Leu Gln Gly Phe Leu Phe Leu Leu Phe Leu Pro 
1               5                   10                  15      


Leu Leu Gln Pro Arg Gly Ala Ser Ala Gly Ser Leu His Ser Pro Gly 
            20                  25                  30          


Leu Ser Glu Cys Phe Gln Val Asn Gly Ala Asp Tyr Arg Gly His Gln 
        35                  40                  45              


Asn Arg Thr Gly Pro Arg Gly Ala Gly Arg Pro Cys Leu Phe Trp Asp 
    50                  55                  60                  


Gln Thr Gln Gln His Ser Tyr Ser Ser Ala Ser Asp Pro His Gly Arg 
65                  70                  75                  80  


Trp Gly Leu Gly Ala His Asn Phe Cys Arg Asn Pro Asp Gly Asp Val 
                85                  90                  95      


Gln Pro Trp Cys Tyr Val Ala Glu Thr Glu Glu Gly Ile Tyr Trp Arg 
            100                 105                 110         


Tyr Cys Asp Ile Pro Ser Cys His Met Pro Gly Tyr Leu Gly Cys Phe 
        115                 120                 125             


Val Asp Ser Gly Ala Pro Pro Ala Leu Ser Gly Pro Ser Gly Thr Ser 
    130                 135                 140                 


Thr Lys Leu Thr Val Gln Val Cys Leu Arg Phe Cys Arg Met Lys Gly 
145                 150                 155                 160 


Tyr Gln Leu Ala Gly Val Glu Ala Gly Tyr Ala Cys Phe Cys Gly Ser 
                165                 170                 175     


Glu Ser Asp Leu Ala Arg Gly Arg Leu Ala Pro Ala Thr Asp Cys Asp 
            180                 185                 190         


Gln Ile Cys Phe Gly His Pro Gly Gln Leu Cys Gly Gly Asp Gly Arg 
        195                 200                 205             


Leu Gly Val Tyr Glu Val Ser Val Gly Ser Cys Gln Gly Asn Trp Thr 
    210                 215                 220                 


Ala Pro Gln Gly Val Ile Tyr Ser Pro Asp Phe Pro Asp Glu Tyr Gly 
225                 230                 235                 240 


Pro Asp Arg Asn Cys Ser Trp Ala Leu Gly Pro Pro Gly Ala Ala Leu 
                245                 250                 255     


Glu Leu Thr Phe Arg Leu Phe Glu Leu Ala Asp Pro Arg Asp Arg Leu 
            260                 265                 270         


Glu Leu Arg Asp Ala Ala Ser Gly Ser Leu Leu Arg Ala Phe Asp Gly 
        275                 280                 285             


Ala Arg Pro Pro Pro Ser Gly Pro Leu Arg Leu Gly Thr Ala Ala Leu 
    290                 295                 300                 


Leu Leu Thr Phe Arg Ser Asp Ala Arg Gly His Ala Gln Gly Phe Ala 
305                 310                 315                 320 


Leu Thr Tyr Arg Gly Leu Gln Asp Ala Ala Glu Asp Pro Glu Ala Pro 
                325                 330                 335     


Glu Gly Ser Ala Gln Thr Pro Ala Ala Pro Leu Asp Gly Ala Asn Val 
            340                 345                 350         


Ser Cys Ser Pro Arg Pro Gly Ala Pro Pro Ala Ala Ile Gly Ala Arg 
        355                 360                 365             


Val Phe Ser Thr Val Thr Ala Val Ser Val Leu Leu Leu Leu Leu Leu 
    370                 375                 380                 


Gly Leu Leu Arg Pro Leu Arg Arg Arg Ser Cys Leu Leu Ala Pro Gly 
385                 390                 395                 400 


Lys Gly Pro Pro Ala Leu Gly Ala Ser Arg Gly Pro Arg Arg Ser Trp 
                405                 410                 415     


Ala Val Trp Tyr Gln Gln Pro Arg Gly Val Ala Leu Pro Cys Ser Pro 
            420                 425                 430         


Gly Asp Pro Gln Ala Glu Gly Ser Ala Ala Gly Tyr Arg Pro Leu Ser 
        435                 440                 445             


Ala Ser Ser Gln Ser Ser Leu Arg Ser Leu Ile Ser Ala Leu 
    450                 455                 460         


<210> 35
<211> 386
<212> PRT
<213> Homo sapiens

<400> 35
Met Gly Leu Trp Gly Gln Ser Val Pro Thr Ala Ser Ser Ala Arg Ala 
1               5                   10                  15      


Gly Arg Tyr Pro Gly Ala Arg Thr Ala Ser Gly Thr Arg Pro Trp Leu 
            20                  25                  30          


Leu Asp Pro Lys Ile Leu Lys Phe Val Val Phe Ile Val Ala Val Leu 
        35                  40                  45              


Leu Pro Val Arg Val Asp Ser Ala Thr Ile Pro Arg Gln Asp Glu Val 
    50                  55                  60                  


Pro Gln Gln Thr Val Ala Pro Gln Gln Gln Arg Arg Ser Leu Lys Glu 
65                  70                  75                  80  


Glu Glu Cys Pro Ala Gly Ser His Arg Ser Glu Tyr Thr Gly Ala Cys 
                85                  90                  95      


Asn Pro Cys Thr Glu Gly Val Asp Tyr Thr Ile Ala Ser Asn Asn Leu 
            100                 105                 110         


Pro Ser Cys Leu Leu Cys Thr Val Cys Lys Ser Gly Gln Thr Asn Lys 
        115                 120                 125             


Ser Ser Cys Thr Thr Thr Arg Asp Thr Val Cys Gln Cys Glu Lys Gly 
    130                 135                 140                 


Ser Phe Gln Asp Lys Asn Ser Pro Glu Met Cys Arg Thr Cys Arg Thr 
145                 150                 155                 160 


Gly Cys Pro Arg Gly Met Val Lys Val Ser Asn Cys Thr Pro Arg Ser 
                165                 170                 175     


Asp Ile Lys Cys Lys Asn Glu Ser Ala Ala Ser Ser Thr Gly Lys Thr 
            180                 185                 190         


Pro Ala Ala Glu Glu Thr Val Thr Thr Ile Leu Gly Met Leu Ala Ser 
        195                 200                 205             


Pro Tyr His Tyr Leu Ile Ile Ile Val Val Leu Val Ile Ile Leu Ala 
    210                 215                 220                 


Val Val Val Val Gly Phe Ser Cys Arg Lys Lys Phe Ile Ser Tyr Leu 
225                 230                 235                 240 


Lys Gly Ile Cys Ser Gly Gly Gly Gly Gly Pro Glu Arg Val His Arg 
                245                 250                 255     


Val Leu Phe Arg Arg Arg Ser Cys Pro Ser Arg Val Pro Gly Ala Glu 
            260                 265                 270         


Asp Asn Ala Arg Asn Glu Thr Leu Ser Asn Arg Tyr Leu Gln Pro Thr 
        275                 280                 285             


Gln Val Ser Glu Gln Glu Ile Gln Gly Gln Glu Leu Ala Glu Leu Thr 
    290                 295                 300                 


Gly Val Thr Val Glu Ser Pro Glu Glu Pro Gln Arg Leu Leu Glu Gln 
305                 310                 315                 320 


Ala Glu Ala Glu Gly Cys Gln Arg Arg Arg Leu Leu Val Pro Val Asn 
                325                 330                 335     


Asp Ala Asp Ser Ala Asp Ile Ser Thr Leu Leu Asp Ala Ser Ala Thr 
            340                 345                 350         


Leu Glu Glu Gly His Ala Lys Glu Thr Ile Gln Asp Gln Leu Val Gly 
        355                 360                 365             


Ser Glu Lys Leu Phe Tyr Glu Glu Asp Glu Ala Gly Ser Ala Thr Ser 
    370                 375                 380                 


Cys Leu 
385     


<210> 36
<211> 350
<212> PRT
<213> Homo sapiens

<400> 36
Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys Met Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys Tyr Val Val Ile Ile Ala Tyr Ala Leu 
        35                  40                  45              


Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met Leu Val Ile 
    50                  55                  60                  


Leu Tyr Ser Arg Val Gly Arg Ser Val Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu Thr Leu Pro Ile Trp Ala 
                85                  90                  95      


Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 
            100                 105                 110         


Val Ser Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Thr Arg 
    130                 135                 140                 


Thr Leu Thr Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly Cys 
145                 150                 155                 160 


Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe Leu Phe Arg Gln 
                165                 170                 175     


Ala Tyr His Pro Asn Asn Ser Ser Pro Val Cys Tyr Glu Val Leu Gly 
            180                 185                 190         


Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Thr 
        195                 200                 205             


Phe Gly Phe Ile Val Pro Leu Phe Val Met Leu Phe Cys Tyr Gly Phe 
    210                 215                 220                 


Thr Leu Arg Thr Leu Phe Lys Ala His Met Gly Gln Lys His Arg Ala 
225                 230                 235                 240 


Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu Cys Trp Leu 
                245                 250                 255     


Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met Arg Thr Gln Val 
            260                 265                 270         


Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 
        275                 280                 285             


Ala Thr Glu Ile Leu Gly Phe Leu His Ser Cys Leu Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Ile Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 
305                 310                 315                 320 


Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val 
                325                 330                 335     


Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser Asn Leu 
            340                 345                 350 


<210> 37
<211> 120
<212> PRT
<213> Homo sapiens

<400> 37
Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Thr Ala 
1               5                   10                  15      


Leu Gly Ser Gln Ala Arg Val Thr Lys Asp Ala Glu Thr Glu Phe Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Leu Leu Asp Arg Phe His 
        35                  40                  45              


Ala Thr Ser Ala Asp Cys Cys Ile Ser Tyr Thr Pro Arg Ser Ile Pro 
    50                  55                  60                  


Cys Ser Leu Leu Glu Ser Tyr Phe Glu Thr Asn Ser Glu Cys Ser Lys 
65                  70                  75                  80  


Pro Gly Val Ile Phe Leu Thr Lys Lys Gly Arg Arg Phe Cys Ala Asn 
                85                  90                  95      


Pro Ser Asp Lys Gln Val Gln Val Cys Val Arg Met Leu Lys Leu Asp 
            100                 105                 110         


Thr Arg Ile Lys Thr Arg Lys Asn 
        115                 120 


<210> 38
<211> 781
<212> PRT
<213> Homo sapiens

<400> 38
Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210> 39
<211> 245
<212> PRT
<213> Homo sapiens

<400> 39
Met Ala Ala Ala Ile Ala Ser Ser Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Arg Glu Lys Ser Asn Ala Cys Lys Cys Val Ser Ser Pro Ser 
            20                  25                  30          


Lys Gly Lys Thr Ser Cys Asp Lys Asn Lys Leu Asn Val Phe Ser Arg 
        35                  40                  45              


Val Lys Leu Phe Gly Ser Lys Lys Arg Arg Arg Arg Arg Pro Glu Pro 
    50                  55                  60                  


Gln Leu Lys Gly Ile Val Thr Lys Leu Tyr Ser Arg Gln Gly Tyr His 
65                  70                  75                  80  


Leu Gln Leu Gln Ala Asp Gly Thr Ile Asp Gly Thr Lys Asp Glu Asp 
                85                  90                  95      


Ser Thr Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg Val Val 
            100                 105                 110         


Ala Ile Gln Gly Val Gln Thr Lys Leu Tyr Leu Ala Met Asn Ser Glu 
        115                 120                 125             


Gly Tyr Leu Tyr Thr Ser Glu Leu Phe Thr Pro Glu Cys Lys Phe Lys 
    130                 135                 140                 


Glu Ser Val Phe Glu Asn Tyr Tyr Val Thr Tyr Ser Ser Met Ile Tyr 
145                 150                 155                 160 


Arg Gln Gln Gln Ser Gly Arg Gly Trp Tyr Leu Gly Leu Asn Lys Glu 
                165                 170                 175     


Gly Glu Ile Met Lys Gly Asn His Val Lys Lys Asn Lys Pro Ala Ala 
            180                 185                 190         


His Phe Leu Pro Lys Pro Leu Lys Val Ala Met Tyr Lys Glu Pro Ser 
        195                 200                 205             


Leu His Asp Leu Thr Glu Phe Ser Arg Ser Gly Ser Gly Thr Pro Thr 
    210                 215                 220                 


Lys Ser Arg Ser Val Ser Gly Val Leu Asn Gly Gly Lys Ser Met Ser 
225                 230                 235                 240 


His Asn Glu Ser Thr 
                245 


<210> 40
<211> 281
<212> PRT
<213> Homo sapiens

<400> 40
Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210> 41
<211> 93
<212> PRT
<213> Homo sapiens

<400> 41
Met Lys Ile Ser Val Ala Ala Ile Pro Phe Phe Leu Leu Ile Thr Ile 
1               5                   10                  15      


Ala Leu Gly Thr Lys Thr Glu Ser Ser Ser Arg Gly Pro Tyr His Pro 
            20                  25                  30          


Ser Glu Cys Cys Phe Thr Tyr Thr Thr Tyr Lys Ile Pro Arg Gln Arg 
        35                  40                  45              


Ile Met Asp Tyr Tyr Glu Thr Asn Ser Gln Cys Ser Lys Pro Gly Ile 
    50                  55                  60                  


Val Phe Ile Thr Lys Arg Gly His Ser Val Cys Thr Asn Pro Ser Asp 
65                  70                  75                  80  


Lys Trp Val Gln Asp Tyr Ile Lys Asp Met Lys Glu Asn 
                85                  90              


<210> 42
<211> 282
<212> PRT
<213> Homo sapiens

<400> 42
Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Glu Gly Ala Glu Leu 
        275                 280         


<210> 43
<211> 206
<212> PRT
<213> Homo sapiens

<400> 43
Met Ser Gly Pro Gly Thr Ala Ala Val Ala Leu Leu Pro Ala Val Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Pro Trp Ala Gly Arg Gly Gly Ala Ala Ala Pro 
            20                  25                  30          


Thr Ala Pro Asn Gly Thr Leu Glu Ala Glu Leu Glu Arg Arg Trp Glu 
        35                  40                  45              


Ser Leu Val Ala Leu Ser Leu Ala Arg Leu Pro Val Ala Ala Gln Pro 
    50                  55                  60                  


Lys Glu Ala Ala Val Gln Ser Gly Ala Gly Asp Tyr Leu Leu Gly Ile 
65                  70                  75                  80  


Lys Arg Leu Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe His Leu 
                85                  90                  95      


Gln Ala Leu Pro Asp Gly Arg Ile Gly Gly Ala His Ala Asp Thr Arg 
            100                 105                 110         


Asp Ser Leu Leu Glu Leu Ser Pro Val Glu Arg Gly Val Val Ser Ile 
        115                 120                 125             


Phe Gly Val Ala Ser Arg Phe Phe Val Ala Met Ser Ser Lys Gly Lys 
    130                 135                 140                 


Leu Tyr Gly Ser Pro Phe Phe Thr Asp Glu Cys Thr Phe Lys Glu Ile 
145                 150                 155                 160 


Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Tyr Lys Tyr Pro Gly 
                165                 170                 175     


Met Phe Ile Ala Leu Ser Lys Asn Gly Lys Thr Lys Lys Gly Asn Arg 
            180                 185                 190         


Val Ser Pro Thr Met Lys Val Thr His Phe Leu Pro Arg Leu 
        195                 200                 205     


<210> 44
<211> 233
<212> PRT
<213> Homo sapiens

<400> 44
Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Glu Gly Pro Gly Arg Gly Pro Ala Leu 
            20                  25                  30          


Gly Arg Glu Leu Ala Ser Leu Phe Arg Ala Gly Arg Glu Pro Gln Gly 
        35                  40                  45              


Val Ser Gln Gln His Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu 
    50                  55                  60                  


Ser Arg Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly 
65                  70                  75                  80  


Lys His Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu 
                85                  90                  95      


Asp Gly Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly 
            100                 105                 110         


Ser Arg Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met 
        115                 120                 125             


Asn Lys Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp 
    130                 135                 140                 


Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln 
145                 150                 155                 160 


Asn Ala Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg 
                165                 170                 175     


Pro Arg Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu Val His Phe 
            180                 185                 190         


Met Lys Arg Leu Pro Arg Gly His His Thr Thr Glu Gln Ser Leu Arg 
        195                 200                 205             


Phe Glu Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser 
    210                 215                 220                 


Gln Arg Thr Trp Ala Pro Glu Pro Arg 
225                 230             


<210> 45
<211> 651
<212> DNA
<213> Homo sapiens

<400> 45
atgggagccg cccgcctgct gcccaacctc actctgtgct tacagctgct gattctctgc       60

tgtcaaactc agggggagaa tcacccgtct cctaatttta accagtacgt gagggaccag      120

ggcgccatga ccgaccagct gagcaggcgg cagatccgcg agtaccaact ctacagcagg      180

accagtggca agcacgtgca ggtcaccggg cgtcgcatct ccgccaccgc cgaggacggc      240

aacaagtttg ccaagctcat agtggagacg gacacgtttg gcagccgggt tcgcatcaaa      300

ggggctgaga gtgagaagta catctgtatg aacaagaggg gcaagctcat cgggaagccc      360

agcgggaaga gcaaagactg cgtgttcacg gagatcgtgc tggagaacaa ctatacggcc      420

ttccagaacg cccggcacga gggctggttc atggccttca cgcggcaggg gcggccccgc      480

caggcttccc gcagccgcca gaaccagcgc gaggcccact tcatcaagcg cctctaccaa      540

ggccagctgc ccttccccaa ccacgccgag aagcagaagc agttcgagtt tgtgggctcc      600

gcccccaccc gccggaccaa gcgcacacgg cggccccagc ccctcacgta g               651


<210> 46
<211> 2886
<212> DNA
<213> Homo sapiens

<400> 46
atgctggccc cgcgcggagc cgccgtcctc ctgctgcacc tggtcctgca gcggtggcta       60

gcggcaggcg cccaggccac cccccaggtc tttgaccttc tcccatcttc cagtcagagg      120

ctaaacccag gcgctctgct gccagtcctg acagaccccg ccctgaatga tctctatgtg      180

atttccacct tcaagctgca gactaaaagt tcagccacca tcttcggtct ttactcttca      240

actgacaaca gtaaatattt tgaatttact gtgatgggac gcttaaacaa agccatcctc      300

cgttacctga agaacgatgg gaaggtgcat ttggtggttt tcaacaacct gcagctggca      360

gacggaaggc ggcacaggat cctcctgagg ctgagcaatt tgcagcgagg ggccggctcc      420

ctagagctct acctggactg catccaggtg gattccgttc acaatctccc cagggccttt      480

gctggcccct cccagaaacc tgagaccatt gaattgagga ctttccagag gaagccacag      540

gacttcttgg aagagctgaa gctggtggtg agaggctcac tgttccaggt ggccagcctg      600

caagactgct tcctgcagca gagtgagcca ctggctgcca caggcacagg ggactttaac      660

cggcagttct tgggtcaaat gacacaatta aaccaactcc tgggagaggt gaaggacctt      720

ctgagacagc aggttaagga aacatcattt ttgcgaaaca ccatagctga atgccaggct      780

tgcggtcctc tcaagtttca gtctccgacc ccaagcacgg tggtgccccc ggctccccct      840

gcaccgccaa cacgcccacc tcgtcggtgt gactccaacc catgtttccg aggtgtccaa      900

tgtaccgaca gtagagatgg cttccagtgt gggccctgcc ccgagggcta cacaggaaac      960

gggatcacct gtattgatgt tgatgagtgc aaataccatc cctgctaccc gggcgtgcac     1020

tgcataaatt tgtctcctgg cttcagatgt gacgcctgcc cagtgggctt cacagggccc     1080

atggtgcagg gtgttgggat cagttttgcc aagtcaaaca agcaggtctg cactgacatt     1140

gatgagtgtc gaaatggagc gtgcgttccc aactcgatct gcgttaatac tttgggatct     1200

taccgctgtg ggccttgtaa gccggggtat actggtgatc agataagggg atgcaaagcg     1260

gaaagaaact gcagaaaccc agagctgaac ccttgcagtg tgaatgccca gtgcattgaa     1320

gagaggcagg gggatgtgac atgtgtgtgt ggagtcggtt gggctggaga tggctatatc     1380

tgtggaaagg atgtggacat cgacagttac cccgacgaag aactgccatg ctctgccagg     1440

aactgtaaaa aggacaactg caaatatgtg ccaaattctg gccaagaaga tgcagacaga     1500

gatggcattg gcgacgcttg tgacgaggat gctgacggag atgggatcct gaatgagcag     1560

gataactgtg tcctgattca taatgtggac caaaggaaca gcgataaaga tatctttggg     1620

gatgcctgtg ataactgcct gagtgtctta aataacgacc agaaagacac cgatggggat     1680

ggaagaggag atgcctgtga tgatgacatg gatggagatg gaataaaaaa cattctggac     1740

aactgcccaa aatttcccaa tcgtgaccaa cgggacaagg atggtgatgg tgtgggggat     1800

gcctgtgaca gttgtcctga tgtcagcaac cctaaccagt ctgatgtgga taatgatctg     1860

gttggggact cctgtgacac caatcaggac agtgatggag atgggcacca ggacagcaca     1920

gacaactgcc ccaccgtcat taacagtgcc cagctggaca ccgataagga tggaattggt     1980

gacgagtgtg atgatgatga tgacaatgat ggtatcccag acctggtgcc ccctggacca     2040

gacaactgcc ggctggtccc caacccagcc caggaggata gcaacagcga cggagtggga     2100

gacatctgtg agtctgactt tgaccaggac caggtcatcg atcggatcga cgtctgccca     2160

gagaacgcag aggtcaccct gaccgacttc agggcttacc agaccgtggt cctggatcct     2220

gaaggggatg cccagatcga tcccaactgg gtggtcctga accagggcat ggagattgta     2280

cagaccatga acagtgatcc tggcctggca gtggggtaca cagcttttaa tggagttgac     2340

ttcgaaggga ccttccatgt gaatacccag acagatgatg actatgcagg ctttatcttt     2400

ggctaccaag atagctccag cttctacgtg gtcatgtgga agcagacgga gcagacatat     2460

tggcaagcca ccccattccg agcagttgca gaacctggca ttcagctcaa ggctgtgaag     2520

tctaagacag gtccagggga gcatctccgg aactccctgt ggcacacggg ggacaccagt     2580

gaccaggtca ggctgctgtg gaaggactcc aggaatgtgg gctggaagga caaggtgtcc     2640

taccgctggt tcctacagca caggccccag gtgggctaca tcagggtacg attttatgaa     2700

ggctctgagt tggtggctga ctctggcgtc accatagaca ccacaatgcg tggaggccga     2760

cttggcgttt tctgcttctc tcaagaaaac atcatctggt ccaacctcaa gtatcgctgc     2820

aatgacacca tccctgagga cttccaagag tttcaaaccc agaatttcga ccgcttcgat     2880

aattaa                                                                2886


<210> 47
<211> 3519
<212> DNA
<213> Homo sapiens

<400> 47
atggtctgga ggctggtcct gctggctctg tgggtgtggc ccagcacgca agctggtcac       60

caggacaaag acacgacctt cgaccttttc agtatcagca acatcaaccg caagaccatt      120

ggcgccaagc agttccgcgg gcccgacccc ggcgtgccgg cttaccgctt cgtgcgcttt      180

gactacatcc caccggtgaa cgcagatgac ctcagcaaga tcaccaagat catgcggcag      240

aaggagggct tcttcctcac ggcccagctc aagcaggacg gcaagtccag gggcacgctg      300

ttggctctgg agggccccgg tctctcccag aggcagttcg agatcgtctc caacggcccc      360

gcggacacgc tggatctcac ctactggatt gacggcaccc ggcatgtggt ctccctggag      420

gacgtcggcc tggctgactc gcagtggaag aacgtcaccg tgcaggtggc tggcgagacc      480

tacagcttgc acgtgggctg cgacctcata gacagcttcg ctctggacga gcccttctac      540

gagcacctgc aggcggaaaa gagccggatg tacgtggcca aaggctctgc cagagagagt      600

cacttcaggg gtttgcttca gaacgtccac ctagtgtttg aaaactctgt ggaagatatt      660

ctaagcaaga agggttgcca gcaaggccag ggagctgaga tcaacgccat cagtgagaac      720

acagagacgc tgcgcctggg tccgcatgtc accaccgagt acgtgggccc cagctcggag      780

aggaggcccg aggtgtgcga acgctcgtgc gaggagctgg gaaacatggt ccaggagctc      840

tcggggctcc acgtcctcgt gaaccagctc agcgagaacc tcaagagagt gtcgaatgat      900

aaccagtttc tctgggagct cattggtggc cctcctaaga caaggaacat gtcagcttgc      960

tggcaggatg gccggttctt tgcggaaaat gaaacgtggg tggtggacag ctgcaccacg     1020

tgtacctgca agaaatttaa aaccatttgc caccaaatca cctgcccgcc tgcaacctgc     1080

gccagtccat cctttgtgga aggcgaatgc tgcccttcct gcctccactc ggtggacggt     1140

gaggagggct ggtctccgtg ggcagagtgg acccagtgct ccgtgacgtg tggctctggg     1200

acccagcaga gaggccggtc ctgtgacgtc accagcaaca cctgcttggg gccctccatc     1260

cagacacggg cttgcagtct gagcaagtgt gacacccgca tccggcagga cggcggctgg     1320

agccactggt caccttggtc ttcatgctct gtgacctgtg gagttggcaa tatcacacgc     1380

atccgtctct gcaactcccc agtgccccag atggggggca agaattgcaa agggagtggc     1440

cgggagacca aagcctgcca gggcgcccca tgcccaatcg atggccgctg gagcccctgg     1500

tccccgtggt cggcctgcac tgtcacctgt gccggtggga tccgggagcg cacccgggtc     1560

tgcaacagcc ctgagcctca gtacggaggg aaggcctgcg tgggggatgt gcaggagcgt     1620

cagatgtgca acaagaggag ctgccccgtg gatggctgtt tatccaaccc ctgcttcccg     1680

ggagcccagt gcagcagctt ccccgatggg tcctggtcat gcggctcctg ccctgtgggc     1740

ttcttgggca atggcaccca ctgtgaggac ctggacgagt gtgccctggt ccccgacatc     1800

tgcttctcca ccagcaaggt gcctcgctgt gtcaacactc agcctggctt ccactgcctg     1860

ccctgcccgc cccgatacag agggaaccag cccgtcgggg tcggcctgga agcagccaag     1920

acggaaaagc aagtgtgtga gcccgaaaac ccatgcaagg acaagacaca caactgccac     1980

aagcacgcgg agtgcatcta cctgggccac ttcagcgacc ccatgtacaa gtgcgagtgc     2040

cagacaggct acgcgggcga cgggctcatc tgcggggagg actcggacct ggacggctgg     2100

cccaacctca atctggtctg cgccaccaac gccacctacc actgcatcaa ggataactgc     2160

ccccatctgc caaattctgg gcaggaagac tttgacaagg acgggattgg cgatgcctgt     2220

gatgatgacg atgacaatga cggtgtgacc gatgagaagg acaactgcca gctcctcttc     2280

aatccccgcc aggctgacta tgacaaggat gaggttgggg accgctgtga caactgccct     2340

tacgtgcaca accctgccca gatcgacaca gacaacaatg gagagggtga cgcctgctcc     2400

gtggacattg atggggacga tgtcttcaat gaacgagaca attgtcccta cgtctacaac     2460

actgaccaga gggacacgga tggtgacggt gtgggggatc actgtgacaa ctgccccctg     2520

gtgcacaacc ctgaccagac cgacgtggac aatgaccttg ttggggacca gtgtgacaac     2580

aacgaggaca tagatgacga cggccaccag aacaaccagg acaactgccc ctacatctcc     2640

aacgccaacc aggctgacca tgacagagac ggccagggcg acgcctgtga ccctgatgat     2700

gacaacgatg gcgtccccga tgacagggac aactgccggc ttgtgttcaa cccagaccag     2760

gaggacttgg acggtgatgg acggggtgat atttgtaaag atgattttga caatgacaac     2820

atcccagata ttgatgatgt gtgtcctgaa aacaatgcca tcagtgagac agacttcagg     2880

aacttccaga tggtcccctt ggatcccaaa gggaccaccc aaattgatcc caactgggtc     2940

attcgccatc aaggcaagga gctggttcag acagccaact cggaccccgg catcgctgta     3000

ggttttgacg agtttgggtc tgtggacttc agtggcacat tctacgtaaa cactgaccgg     3060

gacgacgact atgccggctt cgtctttggt taccagtcaa gcagccgctt ctatgtggtg     3120

atgtggaagc aggtgacgca gacctactgg gaggaccagc ccacgcgggc ctatggctac     3180

tccggcgtgt ccctcaaggt ggtgaactcc accacgggga cgggcgagca cctgaggaac     3240

gcgctgtggc acacggggaa cacgccgggg caggtgcgaa ccttatggca cgaccccagg     3300

aacattggct ggaaggacta cacggcctat aggtggcacc tgactcacag gcccaagact     3360

ggctacatca gagtcttagt gcatgaagga aaacaggtca tggcagactc aggacctatc     3420

tatgaccaaa cctacgctgg cgggcggctg ggtctatttg tcttctctca agaaatggtc     3480

tatttctcag acctcaagta cgaatgcaga gatatttaa                            3519


<210> 48
<211> 2886
<212> DNA
<213> Homo sapiens

<400> 48
atgctggccc cgcgcggagc cgccgtcctc ctgctgcacc tggtcctgca gcggtggcta       60

gcggcaggcg cccaggccac cccccaggtc tttgaccttc tcccatcttc cagtcagagg      120

ctaaacccag gcgctctgct gccagtcctg acagaccccg ccctgaatga tctctatgtg      180

atttccacct tcaagctgca gactaaaagt tcagccacca tcttcggtct ttactcttca      240

actgacaaca gtaaatattt tgaatttact gtgatgggac gcttaaacaa agccatcctc      300

cgttacctga agaacgatgg gaaggtgcat ttggtggttt tcaacaacct gcagctggca      360

gacggaaggc ggcacaggat cctcctgagg ctgagcaatt tgcagcgagg ggccggctcc      420

ctagagctct acctggactg catccaggtg gattccgttc acaatctccc cagggccttt      480

gctggcccct cccagaaacc tgagaccatt gaattgagga ctttccagag gaagccacag      540

gacttcttgg aagagctgaa gctggtggtg agaggctcac tgttccaggt ggccagcctg      600

caagactgct tcctgcagca gagtgagcca ctggctgcca caggcacagg ggactttaac      660

cggcagttct tgggtcaaat gacacaatta aaccaactcc tgggagaggt gaaggacctt      720

ctgagacagc aggttaagga aacatcattt ttgcgaaaca ccatagctga atgccaggct      780

tgcggtcctc tcaagtttca gtctccgacc ccaagcacgg tggtgccccc ggctccccct      840

gcaccgccaa cacgcccacc tcgtcggtgt gactccaacc catgtttccg aggtgtccaa      900

tgtaccgaca gtagagatgg cttccagtgt gggccctgcc ccgagggcta cacaggaaac      960

gggatcacct gtattgatgt tgatgagtgc aaataccatc cctgctaccc gggcgtgcac     1020

tgcataaatt tgtctcctgg cttcagatgt gacgcctgcc cagtgggctt cacagggccc     1080

atggtgcagg gtgttgggat cagttttgcc aagtcaaaca agcaggtctg cactgacatt     1140

gatgagtgtc gaaatggagc gtgcgttccc aactcgatct gcgttaatac tttgggatct     1200

taccgctgtg ggccttgtaa gccggggtat actggtgatc agataagggg atgcaaagcg     1260

gaaagaaact gcagaaaccc agagctgaac ccttgcagtg tgaatgccca gtgcattgaa     1320

gagaggcagg gggatgtgac atgtgtgtgt ggagtcggtt gggctggaga tggctatatc     1380

tgtggaaagg atgtggacat cgacagttac cccgacgaag aactgccatg ctctgccagg     1440

aactgtaaaa aggacaactg caaatatgtg ccaaattctg gccaagaaga tgcagacaga     1500

gatggcattg gcgacgcttg tgacgaggat gctgacggag atgggatcct gaatgagcag     1560

gataactgtg tcctgattca taatgtggac caaaggaaca gcgataaaga tatctttggg     1620

gatgcctgtg ataactgcct gagtgtctta aataacgacc agaaagacac cgatggggat     1680

ggaagaggag atgcctgtga tgatgacatg gatggagatg gaataaaaaa cattctggac     1740

aactgcccaa aatttcccaa tcgtgaccaa cgggacaagg atggtgatgg tgtgggggat     1800

gcctgtgaca gttgtcctga tgtcagcaac cctaaccagt ctgatgtgga taatgatctg     1860

gttggggact cctgtgacac caatcaggac agtgatggag atgggcacca ggacagcaca     1920

gacaactgcc ccaccgtcat taacagtgcc cagctggaca ccgataagga tggaattggt     1980

gacgagtgtg atgatgatga tgacaatgat ggtatcccag acctggtgcc ccctggacca     2040

gacaactgcc ggctggtccc caacccagcc caggaggata gcaacagcga cggagtggga     2100

gacatctgtg agtctgactt tgaccaggac caggtcatcg atcggatcga cgtctgccca     2160

gagaacgcag aggtcaccct gaccgacttc agggcttacc agaccgtggt cctggatcct     2220

gaaggggatg cccagatcga tcccaactgg gtggtcctga accagggcat ggagattgta     2280

cagaccatga acagtgatcc tggcctggca gtggggtaca cagcttttaa tggagttgac     2340

ttcgaaggga ccttccatgt gaatacccag acagatgatg actatgcagg ctttatcttt     2400

ggctaccaag atagctccag cttctacgtg gtcatgtgga agcagacgga gcagacatat     2460

tggcaagcca ccccattccg agcagttgca gaacctggca ttcagctcaa ggctgtgaag     2520

tctaagacag gtccagggga gcatctccgg aactccctgt ggcacacggg ggacaccagt     2580

gaccaggtca ggctgctgtg gaaggactcc aggaatgtgg gctggaagga caaggtgtcc     2640

taccgctggt tcctacagca caggccccag gtgggctaca tcagggtacg attttatgaa     2700

ggctctgagt tggtggctga ctctggcgtc accatagaca ccacaatgcg tggaggccga     2760

cttggcgttt tctgcttctc tcaagaaaac atcatctggt ccaacctcaa gtatcgctgc     2820

aatgacacca tccctgagga cttccaagag tttcaaaccc agaatttcga ccgcttcgat     2880

aattaa                                                                2886


<210> 49
<211> 543
<212> DNA
<213> Homo sapiens

<400> 49
atgggaatcc caatggggaa gtcgatgctg gtgcttctca ccttcttggc cttcgcctcg       60

tgctgcattg ctgcttaccg ccccagtgag accctgtgcg gcggggagct ggtggacacc      120

ctccagttcg tctgtgggga ccgcggcttc tacttcagca ggcccgcaag ccgtgtgagc      180

cgtcgcagcc gtggcatcgt tgaggagtgc tgtttccgca gctgtgacct ggccctcctg      240

gagacgtact gtgctacccc cgccaagtcc gagagggacg tgtcgacccc tccgaccgtg      300

cttccggaca acttccccag ataccccgtg ggcaagttct tccaatatga cacctggaag      360

cagtccaccc agcgcctgcg caggggcctg cctgccctcc tgcgtgcccg ccggggtcac      420

gtgctcgcca aggagctcga ggcgttcagg gaggccaaac gtcaccgtcc cctgattgct      480

ctacccaccc aagaccccgc ccacgggggc gcccccccag agatggccag caatcggaag      540

tga                                                                    543


<210> 50
<211> 489
<212> DNA
<213> Homo sapiens

<400> 50
atgagaattt cgaaaccaca tttgagaagt atttccatcc agtgctactt gtgtttactt       60

ctaaacagtc attttctaac tgaagctggc attcatgtct tcattttggg ctgtttcagt      120

gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt      180

gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac      240

cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt      300

gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac      360

agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag      420

gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac      480

acttcttga                                                              489


<210> 51
<211> 849
<212> DNA
<213> Homo sapiens

<400> 51
atggagcggc cgtcgctgcg cgccctgctc ctcggcgccg ctgggctgct gctcctgctc       60

ctgcccctct cctcttcctc ctcttcggac acctgcggcc cctgcgagcc ggcctcctgc      120

ccgcccctgc ccccgctggg ctgcctgctg ggcgagaccc gcgacgcgtg cggctgctgc      180

cctatgtgcg cccgcggcga gggcgagccg tgcgggggtg gcggcgccgg cagggggtac      240

tgcgcgccgg gcatggagtg cgtgaagagc cgcaagaggc ggaagggtaa agccggggca      300

gcagccggcg gtccgggtgt aagcggcgtg tgcgtgtgca agagccgcta cccggtgtgc      360

ggcagcgacg gcaccaccta cccgagcggc tgccagctgc gcgccgccag ccagagggcc      420

gagagccgcg gggagaaggc catcacccag gtcagcaagg gcacctgcga gcaaggtcct      480

tccatagtga cgccccccaa ggacatctgg aatgtcactg gtgcccaggt gtacttgagc      540

tgtgaggtca tcggaatccc gacacctgtc ctcatctgga acaaggtaaa aaggggtcac      600

tatggagttc aaaggacaga actcctgcct ggtgaccggg acaacctggc cattcagacc      660

cggggtggcc cagaaaagca tgaagtaact ggctgggtgc tggtatctcc tctaagtaag      720

gaagatgctg gagaatatga gtgccatgca tccaattccc aaggacaggc ttcagcatca      780

gcaaaaatta cagtggttga tgccttacat gaaataccag tgaaaaaagg tgaaggtgcc      840

gagctataa                                                              849


<210> 52
<211> 1437
<212> DNA
<213> Homo sapiens

<400> 52
atggcacccc tgagacccct tctcatactg gccctgctgg catgggttgc tctggctgac       60

caagagtcat gcaagggccg ctgcactgag ggcttcaacg tggacaagaa gtgccagtgt      120

gacgagctct gctcttacta ccagagctgc tgcacagact atacggctga gtgcaagccc      180

caagtgactc gcggggatgt gttcactatg ccggaggatg agtacacggt ctatgacgat      240

ggcgaggaga aaaacaatgc cactgtccat gaacaggtgg ggggcccctc cctgacctct      300

gacctccagg cccagtccaa agggaatcct gagcagacac ctgttctgaa acctgaggaa      360

gaggcccctg cgcctgaggt gggcgcctct aagcctgagg ggatagactc aaggcctgag      420

acccttcatc cagggagacc tcagccccca gcagaggagg agctgtgcag tgggaagccc      480

ttcgacgcct tcaccgacct caagaacggt tccctctttg ccttccgagg gcagtactgc      540

tatgaactgg acgaaaaggc agtgaggcct gggtacccca agctcatccg agatgtctgg      600

ggcatcgagg gccccatcga tgccgccttc acccgcatca actgtcaggg gaagacctac      660

ctcttcaagg gtagtcagta ctggcgcttt gaggatggtg tcctggaccc tgattacccc      720

cgaaatatct ctgacggctt cgatggcatc ccggacaacg tggatgcagc cttggccctc      780

cctgcccata gctacagtgg ccgggagcgg gtctacttct tcaaggggaa acagtactgg      840

gagtaccagt tccagcacca gcccagtcag gaggagtgtg aaggcagctc cctgtcggct      900

gtgtttgaac actttgccat gatgcagcgg gacagctggg aggacatctt cgagcttctc      960

ttctggggca gaacctctgc tggtaccaga cagccccagt tcattagccg ggactggcac     1020

ggtgtgccag ggcaagtgga cgcagccatg gctggccgca tctacatctc aggcatggca     1080

ccccgcccct ccttggccaa gaaacaaagg tttaggcatc gcaaccgcaa aggctaccgt     1140

tcacaacgag gccacagccg tggccgcaac cagaactccc gccggccatc ccgcgccacg     1200

tggctgtcct tgttctccag tgaggagagc aacttgggag ccaacaacta tgatgactac     1260

aggatggact ggcttgtgcc tgccacctgt gaacccatcc agagtgtctt cttcttctct     1320

ggagacaagt actaccgagt caatcttcgc acacggcgag tggacactgt ggaccctccc     1380

tacccacgct ccatcgctca gtactggctg ggctgcccag ctcctggcca tctgtag        1437


<210> 53
<211> 2511
<212> DNA
<213> Homo sapiens

<400> 53
atgattccct ttttacccat gttttctcta ctattgctgc ttattgttaa ccctataaac       60

gccaacaatc attatgacaa gatcttggct catagtcgta tcaggggtcg ggaccaaggc      120

ccaaatgtct gtgcccttca acagattttg ggcaccaaaa agaaatactt cagcacttgt      180

aagaactggt ataaaaagtc catctgtgga cagaaaacga ctgtgttata tgaatgttgc      240

cctggttata tgagaatgga aggaatgaaa ggctgcccag cagttttgcc cattgaccat      300

gtttatggca ctctgggcat cgtgggagcc accacaacgc agcgctattc tgacgcctca      360

aaactgaggg aggagatcga gggaaaggga tccttcactt actttgcacc gagtaatgag      420

gcttgggaca acttggattc tgatatccgt agaggtttgg agagcaacgt gaatgttgaa      480

ttactgaatg ctttacatag tcacatgatt aataagagaa tgttgaccaa ggacttaaaa      540

aatggcatga ttattccttc aatgtataac aatttggggc ttttcattaa ccattatcct      600

aatggggttg tcactgttaa ttgtgctcga atcatccatg ggaaccagat tgcaacaaat      660

ggtgttgtcc atgtcattga ccgtgtgctt acacaaattg gtacctcaat tcaagacttc      720

attgaagcag aagatgacct ttcatctttt agagcagctg ccatcacatc ggacatattg      780

gaggcccttg gaagagacgg tcacttcaca ctctttgctc ccaccaatga ggcttttgag      840

aaacttccac gaggtgtcct agaaaggatc atgggagaca aagtggcttc cgaagctctt      900

atgaagtacc acatcttaaa tactctccag tgttctgagt ctattatggg aggagcagtc      960

tttgagacgc tggaaggaaa tacaattgag ataggatgtg acggtgacag tataacagta     1020

aatggaatca aaatggtgaa caaaaaggat attgtgacaa ataatggtgt gatccatttg     1080

attgatcagg tcctaattcc tgattctgcc aaacaagtta ttgagctggc tggaaaacag     1140

caaaccacct tcacggatct tgtggcccaa ttaggcttgg catctgctct gaggccagat     1200

ggagaataca ctttgctggc acctgtgaat aatgcatttt ctgatgatac tctcagcatg     1260

gatcagcgcc tccttaaatt aattctgcag aatcacatat tgaaagtaaa agttggcctt     1320

aatgagcttt acaacgggca aatactggaa accatcggag gcaaacagct cagagtcttc     1380

gtatatcgta cagctgtctg cattgaaaat tcatgcatgg agaaagggag taagcaaggg     1440

agaaacggtg cgattcacat attccgcgag atcatcaagc cagcagagaa atccctccat     1500

gaaaagttaa aacaagataa gcgctttagc accttcctca gcctacttga agctgcagac     1560

ttgaaagagc tcctgacaca acctggagac tggacattat ttgtgccaac caatgatgct     1620

tttaagggaa tgactagtga agaaaaagaa attctgatac gggacaaaaa tgctcttcaa     1680

aacatcattc tttatcacct gacaccagga gttttcattg gaaaaggatt tgaacctggt     1740

gttactaaca ttttaaagac cacacaagga agcaaaatct ttctgaaaga agtaaatgat     1800

acacttctgg tgaatgaatt gaaatcaaaa gaatctgaca tcatgacaac aaatggtgta     1860

attcatgttg tagataaact cctctatcca gcagacacac ctgttggaaa tgatcaactg     1920

ctggaaatac ttaataaatt aatcaaatac atccaaatta agtttgttcg tggtagcacc     1980

ttcaaagaaa tccccgtgac tgtctataca actaaaatta taaccaaagt tgtggaacca     2040

aaaattaaag tgattgaagg cagtcttcag cctattatca aaactgaagg acccacacta     2100

acaaaagtca aaattgaagg tgaacctgaa ttcagactga ttaaagaagg tgaaacaata     2160

actgaagtga tccatggaga gccaattatt aaaaaataca ccaaaatcat tgatggagtg     2220

cctgtggaaa taactgaaaa agagacacga gaagaacgaa tcattacagg tcctgaaata     2280

aaatacacta ggatttctac tggaggtgga gaaacagaag aaactctgaa gaaattgtta     2340

caagaagagg tcaccaaggt caccaaattc attgaaggtg gtgatggtca tttatttgaa     2400

gatgaagaaa ttaaaagact gcttcaggga gacacacccg tgaggaagtt gcaagccaac     2460

aaaaaagttc aaggatctag aagacgatta agggaaggtc gttctcagtg a              2511


<210> 54
<211> 1128
<212> DNA
<213> Homo sapiens

<400> 54
atgaaggtct ggctgctgct tggtcttctg ctggtgcacg aagcgctgga ggatgttact       60

ggccaacacc ttcccaagaa caagcgtcca aaagaaccag gagagaatag aatcaaacct      120

accaacaaga aggtgaagcc caaaattcct aaaatgaagg acagggactc agccaattca      180

gcaccaaaga cgcagtctat catgatgcaa gtgctggata aaggtcgctt ccagaaaccc      240

gccgctaccc tgagtctgct ggcggggcaa actgtagagc ttcgatgtaa agggagtaga      300

attgggtgga gctaccctgc gtatctggac acctttaagg attctcgcct cagcgtcaag      360

cagaatgagc gctacggcca gttgactctg gtcaactcca cctcggcaga cacaggtgaa      420

ttcagctgct gggtgcagct ctgcagcggc tacatctgca ggaaggacga ggccaaaacg      480

ggctccacct acatcttttt tacagagaaa ggagaactct ttgtaccttc tcccagctac      540

ttcgatgttg tctacttgaa cccggacaga caggctgtgg ttccttgtcg ggtgaccgtg      600

ctgtcggcca aagtcacgct ccacagggaa ttcccagcca aggagatccc agccaatgga      660

acggacattg tttatgacat gaagcggggc tttgtgtatc tgcaacctca ttccgagcac      720

cagggtgtgg tttactgcag ggcggaggcc gggggcagat ctcagatctc cgtcaagtac      780

cagctgctct acgtggcggt tcccagtggc cctccctcaa caaccatctt ggcttcttca      840

aacaaagtga aaagtgggga cgacatcagt gtgctctgca ctgtcctggg ggagcccgat      900

gtggaggtgg agttcacctg gatcttccca gggcagaagg atgaaaggcc tgtgacgatc      960

caagacactt ggaggttgat ccacagagga ctgggacaca ccacgagaat ctcccagagt     1020

gtcattacag tggaagactt tgagacgatt gatgcaggat attacatttg cactgctcag     1080

aatcttcaag gacagaccac agtagctacc actgttgagt tttcctga                  1128


<210> 55
<211> 375
<212> PRT
<213> Homo sapiens

<400> 55
Met Lys Val Trp Leu Leu Leu Gly Leu Leu Leu Val His Glu Ala Leu 
1               5                   10                  15      


Glu Asp Val Thr Gly Gln His Leu Pro Lys Asn Lys Arg Pro Lys Glu 
            20                  25                  30          


Pro Gly Glu Asn Arg Ile Lys Pro Thr Asn Lys Lys Val Lys Pro Lys 
        35                  40                  45              


Ile Pro Lys Met Lys Asp Arg Asp Ser Ala Asn Ser Ala Pro Lys Thr 
    50                  55                  60                  


Gln Ser Ile Met Met Gln Val Leu Asp Lys Gly Arg Phe Gln Lys Pro 
65                  70                  75                  80  


Ala Ala Thr Leu Ser Leu Leu Ala Gly Gln Thr Val Glu Leu Arg Cys 
                85                  90                  95      


Lys Gly Ser Arg Ile Gly Trp Ser Tyr Pro Ala Tyr Leu Asp Thr Phe 
            100                 105                 110         


Lys Asp Ser Arg Leu Ser Val Lys Gln Asn Glu Arg Tyr Gly Gln Leu 
        115                 120                 125             


Thr Leu Val Asn Ser Thr Ser Ala Asp Thr Gly Glu Phe Ser Cys Trp 
    130                 135                 140                 


Val Gln Leu Cys Ser Gly Tyr Ile Cys Arg Lys Asp Glu Ala Lys Thr 
145                 150                 155                 160 


Gly Ser Thr Tyr Ile Phe Phe Thr Glu Lys Gly Glu Leu Phe Val Pro 
                165                 170                 175     


Ser Pro Ser Tyr Phe Asp Val Val Tyr Leu Asn Pro Asp Arg Gln Ala 
            180                 185                 190         


Val Val Pro Cys Arg Val Thr Val Leu Ser Ala Lys Val Thr Leu His 
        195                 200                 205             


Arg Glu Phe Pro Ala Lys Glu Ile Pro Ala Asn Gly Thr Asp Ile Val 
    210                 215                 220                 


Tyr Asp Met Lys Arg Gly Phe Val Tyr Leu Gln Pro His Ser Glu His 
225                 230                 235                 240 


Gln Gly Val Val Tyr Cys Arg Ala Glu Ala Gly Gly Arg Ser Gln Ile 
                245                 250                 255     


Ser Val Lys Tyr Gln Leu Leu Tyr Val Ala Val Pro Ser Gly Pro Pro 
            260                 265                 270         


Ser Thr Thr Ile Leu Ala Ser Ser Asn Lys Val Lys Ser Gly Asp Asp 
        275                 280                 285             


Ile Ser Val Leu Cys Thr Val Leu Gly Glu Pro Asp Val Glu Val Glu 
    290                 295                 300                 


Phe Thr Trp Ile Phe Pro Gly Gln Lys Asp Glu Arg Pro Val Thr Ile 
305                 310                 315                 320 


Gln Asp Thr Trp Arg Leu Ile His Arg Gly Leu Gly His Thr Thr Arg 
                325                 330                 335     


Ile Ser Gln Ser Val Ile Thr Val Glu Asp Phe Glu Thr Ile Asp Ala 
            340                 345                 350         


Gly Tyr Tyr Ile Cys Thr Ala Gln Asn Leu Gln Gly Gln Thr Thr Val 
        355                 360                 365             


Ala Thr Thr Val Glu Phe Ser 
    370                 375 


<210> 56
<211> 679
<212> PRT
<213> Homo sapiens

<400> 56
Met Val Pro Gly Val Pro Gly Ala Val Leu Thr Leu Cys Leu Trp Leu 
1               5                   10                  15      


Ala Ala Ser Ser Gly Cys Leu Ala Ala Gly Pro Gly Ala Ala Ala Ala 
            20                  25                  30          


Arg Arg Leu Asp Glu Ser Leu Ser Ala Gly Ser Val Gln Arg Ala Arg 
        35                  40                  45              


Cys Ala Ser Arg Cys Leu Ser Leu Gln Ile Thr Arg Ile Ser Ala Phe 
    50                  55                  60                  


Phe Gln His Phe Gln Asn Asn Gly Ser Leu Val Trp Cys Gln Asn His 
65                  70                  75                  80  


Lys Gln Cys Ser Lys Leu Glu Pro Cys Lys Glu Ser Gly Asp Leu Arg 
                85                  90                  95      


Lys His Gln Cys Gln Ser Phe Cys Glu Pro Leu Phe Pro Lys Lys Ser 
            100                 105                 110         


Tyr Glu Cys Leu Thr Ser Cys Glu Phe Leu Lys Tyr Ile Leu Leu Val 
        115                 120                 125             


Lys Gln Gly Asp Cys Pro Ala Pro Glu Lys Ala Ser Gly Phe Ala Ala 
    130                 135                 140                 


Ala Cys Val Glu Ser Cys Glu Val Asp Asn Glu Cys Ser Gly Val Lys 
145                 150                 155                 160 


Lys Cys Cys Ser Asn Gly Cys Gly His Thr Cys Gln Val Pro Lys Thr 
                165                 170                 175     


Leu Tyr Lys Gly Val Pro Leu Lys Pro Arg Lys Glu Leu Arg Phe Thr 
            180                 185                 190         


Glu Leu Gln Ser Gly Gln Leu Glu Val Lys Trp Ser Ser Lys Phe Asn 
        195                 200                 205             


Ile Ser Ile Glu Pro Val Ile Tyr Val Val Gln Arg Arg Trp Asn Tyr 
    210                 215                 220                 


Gly Ile His Pro Ser Glu Asp Asp Ala Thr His Trp Gln Thr Val Ala 
225                 230                 235                 240 


Gln Thr Thr Asp Glu Arg Val Gln Leu Thr Asp Ile Arg Pro Ser Arg 
                245                 250                 255     


Trp Tyr Gln Phe Arg Val Ala Ala Val Asn Val His Gly Thr Arg Gly 
            260                 265                 270         


Phe Thr Ala Pro Ser Lys His Phe Arg Ser Ser Lys Asp Pro Ser Ala 
        275                 280                 285             


Pro Pro Ala Pro Ala Asn Leu Arg Leu Ala Asn Ser Thr Val Asn Ser 
    290                 295                 300                 


Asp Gly Ser Val Thr Val Thr Ile Val Trp Asp Leu Pro Glu Glu Pro 
305                 310                 315                 320 


Asp Ile Pro Val His His Tyr Lys Val Phe Trp Ser Trp Met Val Ser 
                325                 330                 335     


Ser Lys Ser Leu Val Pro Thr Lys Lys Lys Arg Arg Lys Thr Thr Asp 
            340                 345                 350         


Gly Phe Gln Asn Ser Val Ile Leu Glu Lys Leu Gln Pro Asp Cys Asp 
        355                 360                 365             


Tyr Val Val Glu Leu Gln Ala Ile Thr Tyr Trp Gly Gln Thr Arg Leu 
    370                 375                 380                 


Lys Ser Ala Lys Val Ser Leu His Phe Thr Ser Thr His Ala Thr Asn 
385                 390                 395                 400 


Asn Lys Glu Gln Leu Val Lys Thr Arg Lys Gly Gly Ile Gln Thr Gln 
                405                 410                 415     


Leu Pro Phe Gln Arg Arg Arg Pro Thr Arg Pro Leu Glu Val Gly Ala 
            420                 425                 430         


Pro Phe Tyr Gln Asp Gly Gln Leu Gln Val Lys Val Tyr Trp Lys Lys 
        435                 440                 445             


Thr Glu Asp Pro Thr Val Asn Arg Tyr His Val Arg Trp Phe Pro Glu 
    450                 455                 460                 


Ala Cys Ala His Asn Arg Thr Thr Gly Ser Glu Ala Ser Ser Gly Met 
465                 470                 475                 480 


Thr His Glu Asn Tyr Ile Ile Leu Gln Asp Leu Ser Phe Ser Cys Lys 
                485                 490                 495     


Tyr Lys Val Thr Val Gln Pro Ile Arg Pro Lys Ser His Ser Lys Ala 
            500                 505                 510         


Glu Ala Val Phe Phe Thr Thr Pro Pro Cys Ser Ala Leu Lys Gly Lys 
        515                 520                 525             


Ser His Lys Pro Val Gly Cys Leu Gly Glu Ala Gly His Val Leu Ser 
    530                 535                 540                 


Lys Val Leu Ala Lys Pro Glu Asn Leu Ser Ala Ser Phe Ile Val Gln 
545                 550                 555                 560 


Asp Val Asn Ile Thr Gly His Phe Ser Trp Lys Met Ala Lys Ala Asn 
                565                 570                 575     


Leu Tyr Gln Pro Met Thr Gly Phe Gln Val Thr Trp Ala Glu Val Thr 
            580                 585                 590         


Thr Glu Ser Arg Gln Asn Ser Leu Pro Asn Ser Ile Ile Ser Gln Ser 
        595                 600                 605             


Gln Ile Leu Pro Ser Asp His Tyr Val Leu Thr Val Pro Asn Leu Arg 
    610                 615                 620                 


Pro Ser Thr Leu Tyr Arg Leu Glu Val Gln Val Leu Thr Pro Gly Gly 
625                 630                 635                 640 


Glu Gly Pro Ala Thr Ile Lys Thr Phe Arg Thr Pro Glu Leu Pro Pro 
                645                 650                 655     


Ser Ser Ala His Arg Ser His Leu Lys His Arg His Pro His His Tyr 
            660                 665                 670         


Lys Pro Ser Pro Glu Arg Tyr 
        675                 


<210> 57
<211> 2043
<212> DNA
<213> Homo sapiens

<400> 57
atggtgcccg gggtgcccgg cgcggtcctg accctctgcc tctggctggc ggcctccagc       60

ggctgcctgg cggccggccc cggcgcggct gctgcgcggc ggctggacga gtcgctgtct      120

gccgggagcg tccagcgcgc tcgctgcgcc tccaggtgcc tgagcctgca gatcactcgc      180

atctccgcct tcttccagca cttccagaac aatggttccc tggtttggtg ccagaatcac      240

aagcaatgtt ctaagtgcct ggagccctgc aaggaatcag gggacctgag gaaacaccag      300

tgccaaagct tttgtgagcc tctcttcccc aagaagagct acgaatgctt gaccagctgt      360

gagttcctca aatacatcct gttggtgaag cagggggact gtccggctcc tgagaaagcc      420

agtggatttg cggccgcctg tgttgaaagc tgcgaagttg acaatgagtg ctctggggtg      480

aagaaatgtt gttcgaatgg gtgtggacac acctgtcaag tacccaagac tctgtacaaa      540

ggtgtccccc tgaagcccag aaaagagtta cgatttacag aactgcagtc tggacagctg      600

gaggttaagt ggtcctcgaa attcaatatt tctattgagc ctgtgatcta tgtggtacaa      660

agaagatgga attatggaat ccatcctagc gaagatgacg ccactcactg gcagacagtg      720

gcccagacca cagacgagcg agttcaactg actgacataa gacccagccg atggtaccag      780

tttcgagtgg ctgctgtgaa tgtgcatgga actcgaggct tcactgcccc cagcaaacac      840

ttccgttctt ccaaagatcc atctgcccca ccagcaccgg ctaacctccg gctggccaac      900

tccaccgtca acagtgatgg gagtgtgacc gtcactatag tttgggatct ccccgaggag      960

ccggacatcc ctgtgcatca ttacaaggtc ttttggagct ggatggtcag cagtaagtct     1020

cttgtcccaa caaagaagaa gcggagaaag actacggatg ggtttcaaaa ttctgtgatc     1080

ctggagaaac tccagccaga ctgtgactat gttgtggaat tgcaagccat aacgtactgg     1140

ggacagacac ggctgaagag tgcaaaggtg tcccttcact tcacatcgac acatgcaacc     1200

aacaacaaag aacagcttgt gaaaactaga aaaggtggaa ttcaaacaca actccctttt     1260

caaagacgac gacccactcg cccgctggaa gtcggagctc ccttctatca ggatggccaa     1320

ctgcaagtta aagtctactg gaagaagaca gaagatccca ctgtcaaccg atatcatgtg     1380

cggtggtttc ctgaagcgtg tgcccacaac agaacaaccg gatcagaggc atcatctggc     1440

atgacccacg aaaattacat aattcttcaa gatctgtcat tttcctgcaa gtataaggtg     1500

actgtccaac caatacggcc aaaaagtcac tccaaggcag aagctgtttt cttcactact     1560

ccaccatgct ctgctcttaa ggggaagagc cacaagcctg ttggctgcct gggcgaagca     1620

ggtcatgttc tttctaaggt gctagctaag cctgagaacc tttctgcttc attcatcgtc     1680

caggatgtga acatcaccgg tcacttttct tggaagatgg ccaaggccaa tctctatcag     1740

cccatgactg ggtttcaagt gacttgggct gaggtcacta cggaaagcag acagaacagc     1800

ctacccaaca gcattatttc acagtcccag atcctgcctt ccgatcatta tgtcctaaca     1860

gtgcccaatc tgagaccatc tactctttac cgactggaag tgcaagtgct gaccccagga     1920

ggggaggggc cggccaccat caagacgttc cggacgccgg agctcccacc ctcttcagca     1980

cacagatctc atcttaagca tcgtcatcca catcattaca agccttctcc agaaagatac     2040

taa                                                                   2043


<210> 58
<211> 1085
<212> PRT
<213> Homo sapiens

<400> 58
Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His Ser Gly Gln Val Phe 
            20                  25                  30          


Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu Asp Leu Ser Leu Thr 
        35                  40                  45              


Val Gln Gly Lys Gln His Val Val Ser Val Glu Glu Ala Leu Leu Ala 
    50                  55                  60                  


Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val Gln Glu Asp Arg Ala 
65                  70                  75                  80  


Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn Ala Glu Leu Asp Val 
                85                  90                  95      


Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala Ser Ile Ala Arg Leu 
            100                 105                 110         


Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe Gln Gly Val Leu Gln 
        115                 120                 125             


Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu Asp Ile Leu Arg Asn 
    130                 135                 140                 


Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu Thr Leu Asp Asn Asn 
145                 150                 155                 160 


Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr Asn Tyr Ile Gly His 
                165                 170                 175     


Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile Ser Cys Asp Glu Leu 
            180                 185                 190         


Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg Thr Ile Val Thr Thr 
        195                 200                 205             


Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu Asn Lys Glu Leu Ala 
    210                 215                 220                 


Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His Asn Gly Val Gln Tyr 
225                 230                 235                 240 


Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys Thr Glu Cys His Cys 
                245                 250                 255     


Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser Cys Pro Ile Met Pro 
            260                 265                 270         


Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys Cys Pro Arg Cys Trp 
        275                 280                 285             


Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro Trp Ser Glu Trp Thr 
    290                 295                 300                 


Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln Gln Arg Gly Arg Ser 
305                 310                 315                 320 


Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser Ser Val Gln Thr Arg 
                325                 330                 335     


Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe Lys Gln Asp Gly Gly 
            340                 345                 350         


Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser Val Thr Cys Gly Asp 
        355                 360                 365             


Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser Pro Ser Pro Gln Met 
    370                 375                 380                 


Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu Thr Lys Ala Cys Lys 
385                 390                 395                 400 


Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly Pro Trp Ser Pro Trp 
                405                 410                 415     


Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val Gln Lys Arg Ser Arg 
            420                 425                 430         


Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly Lys Asp Cys Val Gly 
        435                 440                 445             


Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln Asp Cys Pro Ile Asp 
    450                 455                 460                 


Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val Lys Cys Thr Ser Tyr 
465                 470                 475                 480 


Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro Pro Gly Tyr Ser Gly 
                485                 490                 495     


Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys Lys Glu Val Pro Asp 
            500                 505                 510         


Ala Cys Phe Asn His Asn Gly Glu His Arg Cys Glu Asn Thr Asp Pro 
        515                 520                 525             


Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe Thr Gly Ser Gln Pro 
    530                 535                 540                 


Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn Lys Gln Val Cys Lys 
545                 550                 555                 560 


Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp Cys Asn Lys Asn Ala 
                565                 570                 575     


Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro Met Tyr Arg Cys Glu 
            580                 585                 590         


Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile Cys Gly Glu Asp Thr 
        595                 600                 605             


Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val Cys Val Ala Asn Ala 
    610                 615                 620                 


Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn Leu Pro Asn Ser Gly 
625                 630                 635                 640 


Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp Ala Cys Asp Asp Asp 
                645                 650                 655     


Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp Asn Cys Pro Phe His 
            660                 665                 670         


Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp Asp Val Gly Asp Arg 
        675                 680                 685             


Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp Gln Ala Asp Thr Asp 
    690                 695                 700                 


Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp Ile Asp Gly Asp Gly 
705                 710                 715                 720 


Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val Tyr Asn Val Asp Gln 
                725                 730                 735     


Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln Cys Asp Asn Cys Pro 
            740                 745                 750         


Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp Ser Asp Arg Ile Gly 
        755                 760                 765             


Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu Asp Gly His Gln Asn 
    770                 775                 780                 


Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala Asn Gln Ala Asp His 
785                 790                 795                 800 


Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His Asp Asp Asp Asn Asp 
                805                 810                 815     


Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu Val Pro Asn Pro Asp 
            820                 825                 830         


Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp Ala Cys Lys Asp Asp 
        835                 840                 845             


Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp Ile Cys Pro Glu Asn 
    850                 855                 860                 


Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe Gln Met Ile Pro Leu 
865                 870                 875                 880 


Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn Trp Val Val Arg His 
                885                 890                 895     


Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys Asp Pro Gly Leu Ala 
            900                 905                 910         


Val Gly Tyr Asp Glu Phe Asn Ala Val Asp Phe Ser Gly Thr Phe Phe 
        915                 920                 925             


Ile Asn Thr Glu Arg Asp Asp Asp Tyr Ala Gly Phe Val Phe Gly Tyr 
    930                 935                 940                 


Gln Ser Ser Ser Arg Phe Tyr Val Val Met Trp Lys Gln Val Thr Gln 
945                 950                 955                 960 


Ser Tyr Trp Asp Thr Asn Pro Thr Arg Ala Gln Gly Tyr Ser Gly Leu 
                965                 970                 975     


Ser Val Lys Val Val Asn Ser Thr Thr Gly Pro Gly Glu His Leu Arg 
            980                 985                 990         


Asn Ala Leu Trp His Thr Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu 
        995                 1000                 1005             


Trp His  Asp Pro Arg His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr 
    1010                 1015                 1020             


Arg Trp  Arg Leu Ser His Arg  Pro Lys Thr Gly Phe  Ile Arg Val 
    1025                 1030                 1035             


Val Met  Tyr Glu Gly Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile 
    1040                 1045                 1050             


Tyr Asp  Lys Thr Tyr Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe 
    1055                 1060                 1065             


Ser Gln  Glu Met Val Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg 
    1070                 1075                 1080             


Asp Pro  
    1085 


<210> 59
<211> 205
<212> PRT
<213> Homo sapiens

<400> 59
Met Gly Ala Ala Arg Leu Leu Pro Asn Leu Thr Leu Cys Leu Gln Leu 
1               5                   10                  15      


Leu Ile Leu Cys Cys Gln Thr Gln Tyr Val Arg Asp Gln Gly Ala Met 
            20                  25                  30          


Thr Asp Gln Leu Ser Arg Arg Gln Ile Arg Glu Tyr Gln Leu Tyr Ser 
        35                  40                  45              


Arg Thr Ser Gly Lys His Val Gln Val Thr Gly Arg Arg Ile Ser Ala 
    50                  55                  60                  


Thr Ala Glu Asp Gly Asn Lys Phe Ala Lys Leu Ile Val Glu Thr Asp 
65                  70                  75                  80  


Thr Phe Gly Ser Arg Val Arg Ile Lys Gly Ala Glu Ser Glu Lys Tyr 
                85                  90                  95      


Ile Cys Met Asn Lys Arg Gly Lys Leu Ile Gly Lys Pro Ser Gly Lys 
            100                 105                 110         


Ser Lys Asp Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr 
        115                 120                 125             


Ala Phe Gln Asn Ala Arg His Glu Gly Trp Phe Met Ala Phe Thr Arg 
    130                 135                 140                 


Gln Gly Arg Pro Arg Gln Ala Ser Arg Ser Arg Gln Asn Gln Arg Glu 
145                 150                 155                 160 


Ala His Phe Ile Lys Arg Leu Tyr Gln Gly Gln Leu Pro Phe Pro Asn 
                165                 170                 175     


His Ala Glu Lys Gln Lys Gln Phe Glu Phe Val Gly Ser Ala Pro Thr 
            180                 185                 190         


Arg Arg Thr Lys Arg Thr Arg Arg Pro Gln Pro Leu Thr 
        195                 200                 205 


<210> 60
<211> 779
<212> PRT
<213> Homo sapiens

<400> 60
Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Lys Pro Ile 
            660                 665                 670         


Ile Lys Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr 
        675                 680                 685             


Glu Lys Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys 
    690                 695                 700                 


Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys 
705                 710                 715                 720 


Lys Leu Leu Gln Glu Glu Val Thr Lys Val Thr Lys Phe Ile Glu Gly 
                725                 730                 735     


Gly Asp Gly His Leu Phe Glu Asp Glu Glu Ile Lys Arg Leu Leu Gln 
            740                 745                 750         


Gly Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val Gln Gly 
        755                 760                 765             


Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
    770                 775                 


<210> 61
<211> 781
<212> PRT
<213> Homo sapiens

<400> 61
Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Arg Pro Thr 
            660                 665                 670         


Leu Thr Lys Val Lys Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys 
        675                 680                 685             


Glu Gly Glu Thr Ile Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys 
    690                 695                 700                 


Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys 
705                 710                 715                 720 


Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr 
                725                 730                 735     


Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu 
            740                 745                 750         


Leu Gln Glu Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val 
        755                 760                 765             


Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
    770                 775                 780     


<210> 62
<211> 751
<212> PRT
<213> Homo sapiens

<400> 62
Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Lys Pro Ile 
            660                 665                 670         


Ile Lys Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr 
        675                 680                 685             


Glu Lys Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys 
    690                 695                 700                 


Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys 
705                 710                 715                 720 


Lys Leu Leu Gln Glu Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys 
                725                 730                 735     


Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
            740                 745                 750     


<210> 63
<211> 809
<212> PRT
<213> Homo sapiens

<400> 63
Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Arg Pro Thr 
            660                 665                 670         


Leu Thr Lys Val Lys Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys 
        675                 680                 685             


Glu Gly Glu Thr Ile Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys 
    690                 695                 700                 


Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys 
705                 710                 715                 720 


Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr 
                725                 730                 735     


Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu 
            740                 745                 750         


Leu Gln Glu Glu Val Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp 
        755                 760                 765             


Gly His Leu Phe Glu Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp 
    770                 775                 780                 


Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg 
785                 790                 795                 800 


Arg Arg Leu Arg Glu Gly Arg Ser Gln 
                805                 


<210> 64
<211> 749
<212> PRT
<213> Homo sapiens

<400> 64
Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Ser Pro Glu 
            660                 665                 670         


Ile Lys Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr 
        675                 680                 685             


Leu Lys Lys Leu Leu Gln Glu Glu Val Thr Lys Val Thr Lys Phe Ile 
    690                 695                 700                 


Glu Gly Gly Asp Gly His Leu Phe Glu Asp Glu Glu Ile Lys Arg Leu 
705                 710                 715                 720 


Leu Gln Gly Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val 
                725                 730                 735     


Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
            740                 745                 


<210> 65
<211> 721
<212> PRT
<213> Homo sapiens

<400> 65
Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Ser Pro Glu 
            660                 665                 670         


Ile Lys Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr 
        675                 680                 685             


Leu Lys Lys Leu Leu Gln Glu Asp Thr Pro Val Arg Lys Leu Gln Ala 
    690                 695                 700                 


Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser 
705                 710                 715                 720 


Gln 
    


<210> 66
<211> 183
<212> PRT
<213> Homo sapiens

<400> 66
Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Arg Leu Pro Gly Arg Pro Ala Ser Arg Val Ser Arg 
    50                  55                  60                  


Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu 
65                  70                  75                  80  


Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp 
                85                  90                  95      


Val Ser Thr Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro 
            100                 105                 110         


Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg 
        115                 120                 125             


Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val 
    130                 135                 140                 


Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro 
145                 150                 155                 160 


Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro 
                165                 170                 175     


Glu Met Ala Ser Asn Arg Lys 
            180             


<210> 67
<211> 236
<212> PRT
<213> Homo sapiens

<400> 67
Met Val Ser Pro Asp Pro Gln Ile Ile Val Val Ala Pro Glu Thr Glu 
1               5                   10                  15      


Leu Ala Ser Met Gln Val Gln Arg Thr Glu Asp Gly Val Thr Ile Ile 
            20                  25                  30          


Gln Ile Phe Trp Val Gly Arg Lys Gly Glu Leu Leu Arg Arg Thr Pro 
        35                  40                  45              


Val Ser Ser Ala Met Gln Thr Pro Met Gly Ile Pro Met Gly Lys Ser 
    50                  55                  60                  


Met Leu Val Leu Leu Thr Phe Leu Ala Phe Ala Ser Cys Cys Ile Ala 
65                  70                  75                  80  


Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
                85                  90                  95      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            100                 105                 110         


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        115                 120                 125             


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    130                 135                 140                 


Lys Ser Glu Arg Asp Val Ser Thr Pro Pro Thr Val Leu Pro Asp Asn 
145                 150                 155                 160 


Phe Pro Arg Tyr Pro Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys 
                165                 170                 175     


Gln Ser Thr Gln Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala 
            180                 185                 190         


Arg Arg Gly His Val Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala 
        195                 200                 205             


Lys Arg His Arg Pro Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala His 
    210                 215                 220                 


Gly Gly Ala Pro Pro Glu Met Ala Ser Asn Arg Lys 
225                 230                 235     


<210> 68
<211> 135
<212> PRT
<213> Homo sapiens

<400> 68
Met Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu 
1               5                   10                  15      


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
            20                  25                  30          


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
        35                  40                  45              


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
    50                  55                  60                  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
65                  70                  75                  80  


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
                85                  90                  95      


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            100                 105                 110         


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
        115                 120                 125             


Gln Met Phe Ile Asn Thr Ser 
    130                 135 


<210> 69
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 69
His His His His His His 
1               5       


<210> 70
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      10xHis tag

<400> 70
His His His His His His His His His His 
1               5                   10  


